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<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQC5</accession>
    <name>A0A2I2FQC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_371375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000024">
        <property type="protein sequence ID" value="PLB42834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371375"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="113" mass="12650" checksum="B7E0F2036D190AEE" modified="2018-02-28" version="1" fragment="single">SQSLSRSYGSILPTSLIYIVLSTRGCSPWRPAAVMSTTWRENYSFPRIFKGRRGRTGPCKGAGLCQPWNPSSGQTDFRVIGCQEEKITLPRTPPTSPRSVTLPWRIHIQVPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQK9</accession>
    <name>A0A2I2FQK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_312082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000019">
        <property type="protein sequence ID" value="PLB42899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698201.1">
        <property type="nucleotide sequence ID" value="XM_024843254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQK9"/>
    <dbReference type="GeneID" id="36550954"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_312082"/>
    <dbReference type="OrthoDB" id="3470073at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="13509" checksum="557EE7DCB71AFA0A" modified="2018-02-28" version="1" fragment="single">IPKFDDRFARQNRCEPPPEFPLASPYSGIVHHLSGPHIYALTQIHPKTSGSVDGAPREGAPTSVRFHCAHGFDTRTLAVRAEARSSVQAGSIAPPAIRCPEGHYIPGAFDLPPKPTLARPRGSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSL7</accession>
    <name>A0A2I2FSL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_58709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698940.1">
        <property type="nucleotide sequence ID" value="XM_024855289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSL7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSL7"/>
    <dbReference type="GeneID" id="36562995"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_58709"/>
    <dbReference type="OrthoDB" id="4509729at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="181" mass="19611" checksum="E7FF565D2BC4448A" modified="2018-02-28" version="1">MPSSNIHPTFSSTQIPTLNSNHTHPHPHLHPPSHLLRPRADSPKRSISYTTTPTHVATPVATPVATTSTTAGTGTGTALPRQEKHDDLTCDHKVKGALTELLNDGCVKADVRGRRSVQRLLMETERELRMQRRESLGRRGRRRGEVALEIEGASSEGSESVSGESISKRDGDGDGEEQGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSN0</accession>
    <name>A0A2I2FSN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane translocase complex, subunit Tom5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_480600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698945.1">
        <property type="nucleotide sequence ID" value="XM_024853795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSN0"/>
    <dbReference type="GeneID" id="36561493"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480600"/>
    <dbReference type="OrthoDB" id="4150500at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28188">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28188:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="5368" checksum="8E681B2A65CAA2E0" modified="2018-02-28" version="1">MFAPGQEQLSKEEIKAGEAQACQTVNMAITGAVFLYLSPFAVDFVKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTP8</accession>
    <name>A0A2I2FTP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stomatin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_468681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699259.1">
        <property type="nucleotide sequence ID" value="XM_024852568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTP8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTP8"/>
    <dbReference type="GeneID" id="36560266"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468681"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="87"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="423" mass="45748" checksum="292411B49E3B3009" modified="2018-02-28" version="1">MEVASRHTARLLRSLPSSSYRLIHNSRLPASSLTTTNTLNRIRRRNVSTSSRRQAPEQSLLNFGGGPSTSGGMPAYFANHSTLPMNTVIRFVPQQTAWIVERMGKFHRILDPGLAILIPFLDRIAYVKSLKESAIEIPSQNAITADNVTLELDGVLYTRVFDAYKASYGVEDAEYAISQLAQTTMRSEIGQLTLDHVLKERATLNTNITQAINEAAQAWGVTCLRYEIRDIHAPDGVVAAMHRQVTAERSKRAEILESEGQRQSAINIAEGRKQSVILASEAMRAEQINRADGEAEAILLRAQATSRGIDAVARAIEAGKENAHGAVSLSVAEKYVDAFSKLAKEGTSVVVPGNVGDLGGMIANAMAVYGNVSGSQAKTIAAKTLGVQQSASTESPSTKPEQEKKEGVVGDVLQSFDQSTESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTR8</accession>
    <name>A0A2I2FTR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_451145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699342.1">
        <property type="nucleotide sequence ID" value="XM_024851171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTR8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTR8"/>
    <dbReference type="GeneID" id="36558870"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451145"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="134"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="364"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="446"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="722" mass="80343" checksum="E0DE6C857ED449E8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUN5</accession>
    <name>A0A2I2FUN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_283832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699655.1">
        <property type="nucleotide sequence ID" value="XM_024843200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUN5"/>
    <dbReference type="GeneID" id="36550899"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_283832"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="106" mass="11751" checksum="C7597EAA80D10AD5" modified="2018-02-28" version="1">MEFEIALYKSSTIVSQSKHAIPTAVPSPYTVVSVYTISVISASLIALLCTTLSLTPRKSIFQRHRTDQLVSVCIFPTACKCLTPCSICHTTADLSRYQRETFDMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUU5</accession>
    <name>A0A2I2FUU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_450533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699715.1">
        <property type="nucleotide sequence ID" value="XM_024851130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUU5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUU5"/>
    <dbReference type="GeneID" id="36558829"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450533"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="286" mass="32005" checksum="CA94FFEF508DD4C7" modified="2018-02-28" version="1">MTRTDTIAASQPPVESIPRGTAQVEIKFYKAPVDGSQPFLYKGTPPEGLPAMNYTEPELPVTLNDIRGREDEFSLDKDAFQPLQGVLRVPYEAIQSEETIQSTWYPAVEEFLLDSIKGAHRVIIFDYVIRMESVDTHRKPLHTAHADQTAQAAAARVRLCIPDPREAEQALRGRYRIINVWKPLKGPVQSCPLAFARAGSVQSTELVPIKFHQPHRTGEIIGVAFNKAQEWLYWSGMQPDECLLLKCSDSDESVAGRVPHSAFYDPRTPPNAPGRESIEFRTLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUX3</accession>
    <name>A0A2I2FUX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_468126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699747.1">
        <property type="nucleotide sequence ID" value="XM_024852533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUX3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUX3"/>
    <dbReference type="GeneID" id="36560231"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468126"/>
    <dbReference type="OrthoDB" id="5424797at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="654" mass="71110" checksum="E612C5E44ABDA977" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVY3</accession>
    <name>A0A2I2FVY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_266959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700090.1">
        <property type="nucleotide sequence ID" value="XM_024843121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVY3"/>
    <dbReference type="GeneID" id="36550820"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_266959"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="65" mass="7238" checksum="850DF1FEF6EF2473" modified="2018-02-28" version="1">MAEKIASSDPSMTSKQRTVPMEVLNLSMSRTGTMCEHIFSLNQATVIPQLRLQSETMLSSTIQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWJ3</accession>
    <name>A0A2I2FWJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_440131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700238.1">
        <property type="nucleotide sequence ID" value="XM_024850002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWJ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWJ3"/>
    <dbReference type="GeneID" id="36557701"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440131"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="207"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="596" mass="65365" checksum="20764DB64458BE08" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWM7</accession>
    <name>A0A2I2FWM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_450077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700344.1">
        <property type="nucleotide sequence ID" value="XM_024851092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWM7"/>
    <dbReference type="GeneID" id="36558791"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450077"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013989294" evidence="2">
        <location>
            <begin position="18"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="426" mass="45331" checksum="7B50F4FB3406B02E" modified="2018-02-28" version="1">MLHIASVLLIVAGQLLAINPSSTNTPNQHSPPLLPTQDPFYKPDNSSWESSPPGKIIKSRAVNLTSTIIDLSIVQSAHQHLYRTSDAHGCPSYAVTTVLIPKNATDRHFLSFQVAYDSPDSNCSPSYWAQDGVPANPYGIFGDFSTLIQTFLSQGIPISIPDYEGVNASFTVGTQSGYAVLDSLRAVQRSGSIVGASSATKAAMLGYSGGALATEWATELHAVYAPDVQISGAAIGGLPTNITKTFFAINGTPSAGLISAAFNGIANTFPCFGSYLDRHLLPERAGQFYSTKYQCSRGSRGGLGQMSPCWEPRMSAYFDNGDRIVYDHATLLNTFGTMGSHGTPICPLYIWKGTNDEIAPPIEDTDALVKSYCAGGTNITYVRVENGTHRDAMVAGIPGAMAFLKSLLGGRGLDRCTSTTIPIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX34</accession>
    <name>A0A2I2FX34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_450193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700500.1">
        <property type="nucleotide sequence ID" value="XM_024851106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX34"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX34"/>
    <dbReference type="GeneID" id="36558805"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450193"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="414" mass="46264" checksum="5CB56F155EF4CB35" modified="2018-02-28" version="1">MHELDPLVIEYQHDKHRPRESEALLVLRKVASLVKPIMRRRGWKVGTLSEFYPQQRNLLGLNINGGQKICLRLRYPSDQRQFLPIEHVVDTMLHELCHIVHGPHNQQFHALWNQLRDEHEELAMKGYTGEGFLSQGKRLGGRRMPVEEARRQARAAAEQRRALSAGSGQRLGGAPVLRGTDMRRVIADAAQRRIDVTKGCASGADNSADLAEEASRNGFRTKAEEDDANEQAIMEAFIDLIEQEERERYGPSYIPPSQNNPAGPRSNLSPPPVPHDTRPPAPVQPQEPVDLTSDDSLYEQPWACPICTLENPATFLCCDACAAERPRPSNTRSVSGPPAMNSAASNDRNKRKRPANHTAGHNAFKNRSSAVETLAALDRSTPKRPLGWVCDFCSTFMETEWWTCSNCGTMKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXH8</accession>
    <name>A0A2I2FXH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_278490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700588.1">
        <property type="nucleotide sequence ID" value="XM_024843178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXH8"/>
    <dbReference type="GeneID" id="36550877"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_278490"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="136" mass="15536" checksum="16B8FE2ED70E6105" modified="2018-02-28" version="1">MQCSSTVHPDAEEVCWKLHLRHRRIQSVSDGPGRIRDLDPSKGSPWPGSCFLSCLWFVCFPRLIWIIWSPESVLSPPPPQDSWWVFRCGFEYGCSSWTVLAHALLPRAGPEGLKDPIHHELIINLARDAASRRFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY19</accession>
    <name>A0A2I2FY19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_245785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700825.1">
        <property type="nucleotide sequence ID" value="XM_024842984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY19"/>
    <dbReference type="GeneID" id="36550683"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_245785"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="157" mass="17263" checksum="E72548C34BEDA7EB" modified="2018-02-28" version="1">MYSPGCHCCLQISNQHASTQPSQKRTDSQHGQKMPSPETPSLWSACPSKKRIDADGHVGAHSPGRGDAKRQARNKTLRRRHCNQTQIRRISHVALSRRSPTLLPSPAVIPPHLSVSDGLVPRLLTGFLRVSPSLRPCNRLLSTSQLPPFLSVKLPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYE3</accession>
    <name>A0A2I2FYE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_449306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700952.1">
        <property type="nucleotide sequence ID" value="XM_024851034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYE3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYE3"/>
    <dbReference type="GeneID" id="36558733"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449306"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000522">
        <property type="entry name" value="Forkhead domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="216"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="216"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="463" mass="50343" checksum="4AC85E624F230373" modified="2018-02-28" version="1">MDRYVPSSNFQLETAGSSSVSDGALGETSRHSNPCSTIENWTSSNSRSPGSMISCQHPCAVGMPPSYSMGPSHPPMETVAEGGPRVFPYDQGWPSSLMAPSSTTAPLQPGLRRSHEYNGPPEWGRETDGSTFNPDPSSYASSRAHVSPQHQPEASGTHYPSTTLSPPSPTISVASYQSGHGSSKPHPSSTKPGMERDDMQTSPEDTEEDANADPPYSLLIYQALRNAPDMKLPLQGIYSWFVKNTAKGKDRNSKGWQNSIRHNLSMNAGFEAVREESVPGKKSVNYWRLTDEAVKNGIQSTTRYRKQANYKKTLGSDPPAPQRQRSGAKGGKATKITAKFRGHVSQDELRRERCRQRLACQRRPPKGLYGQYYHHHQSPTTTVSPFHVPGPPLTRPSVEPFDLGSVVGCADAPPCTPIFCDMAGPAPDCPAMDNGFMGWCVLQPFPHGLLTGPEISSDLHLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYP7</accession>
    <name>A0A2I2FYP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum-based factor for assembly of V-ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_439474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701054.1">
        <property type="nucleotide sequence ID" value="XM_024849843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYP7"/>
    <dbReference type="GeneID" id="36557542"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439474"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33894" checksum="AD64F9301DE44021" modified="2018-02-28" version="1">MVRLVTTSRIVSALEDVPPSSRQELDLPDTLSLEGPIAHEQIIRLARYFRTRNDTSISSDDRSLNSLLRGTKVYVPPPPKKPEPSPEYLALKARLLAAAEADAYKRMTSPHLPSSQSPASIFSSSTPTLSAIHESKSSGDQSVDDSDPLTPGLVLNIFLSVLLTGFSVYWALTSFRTPDLLVALVATVWRSSNRTGSQGGVSEPVRVLISLLVALMVGVAEVLIYAIYLRKVEQARAREKRIRERKVVVEGDDQNPSGEDTANTAGEGNATVIPPDGEKAEIWGRGPNGGLRRRVRERWEEKEKEEDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYW8</accession>
    <name>A0A2I2FYW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mitochondrial F1F0 ATP synthase subunit Atp18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_478684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701048.1">
        <property type="nucleotide sequence ID" value="XM_024853585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYW8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYW8"/>
    <dbReference type="GeneID" id="36561283"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478684"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="57" mass="6104" checksum="CE37690028DC0606" modified="2018-02-28" version="1">MSLLGKKFPTPVAKPMAPFFAAGAVILYGINSAANAMMNTAEFKNDPRNPNAKNVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZN9</accession>
    <name>A0A2I2FZN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_479012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701395.1">
        <property type="nucleotide sequence ID" value="XM_024853616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZN9"/>
    <dbReference type="GeneID" id="36561314"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479012"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="279" mass="31028" checksum="02E8B22DFBD7E503" modified="2018-02-28" version="1">MKDLPRKKSKESLFACFPEFSSDDEQDVSQEILNFCNQNSDVMSNLSIKKNRGIARTQMEEFRSQVVEVLYQIAMIMRKNRDRRKQKPKDEEPAPAAGSAAPVPLLPSHPSLPAAAGAGLAASGLTQYTSMFPAAAATNPSTVTFPARLTTSGTIQQPAPQLNPSNYFADYPVWIYRGEMVIKSFPLRSFLGEGATRSPWTTELGIPQLRRTDLSFARCLDILRAQCGFHPTTEVLKGLIGVVTFTMERVELEDESRWLQALNDGFNGGMYPLYIEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZW4</accession>
    <name>A0A2I2FZW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1593-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_479090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701471.1">
        <property type="nucleotide sequence ID" value="XM_024853627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZW4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZW4"/>
    <dbReference type="GeneID" id="36561325"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479090"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="2">
        <location>
            <begin position="369"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="502" mass="56132" checksum="3758BD075DD25FF3" modified="2018-02-28" version="1">MTRSQVDNRIPDLTRLALPPSKPRVFLLTDIENEPDDQESLVRYLLYSNEFETRGICAVTSAWLPTRTAPESIRTTIKAYALVVDNLNQHVHPDARYPTAEALLKLVSSGAPVYGKQALSLPLSPGARDLVNKVQESTEPLWVLSWGGTNVLAETLQHIHETKTPAEEAVLHSRLRVYTISDQDDTGEWIRNAFPAVFFICSIHGFGAFDMSTWQGISHPISGGDLSKVSAEWLRAHIQKGPLGKVYPTPMHIMEGDTPTFLYLIQNGLGHPERPDFGSWGGRYRAVNVGSAHYADVVDTLVGPNKTERTDQKATICRWRDHFQNDFVTRMSWSVTSHFWQASHPPVPIVDGHQGPACMTRKVKSGDIVVLDASKTYDPDHPEDNSHLEFQWYQYLEPTLSHPIGAQAVPRCTIKPLSPPPGTSRRLVYNDAGFEDVALGPCVEVVVPDSKKPAMFGMPVQHWLPYTGVDGMFYHIILQVSHRKAQFPVHRYLRIILDAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G014</accession>
    <name>A0A2I2G014_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_479087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701468.1">
        <property type="nucleotide sequence ID" value="XM_024853626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G014"/>
    <dbReference type="GeneID" id="36561324"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479087"/>
    <dbReference type="OrthoDB" id="4501663at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="354" mass="39917" checksum="80D89D77CED62CA6" modified="2018-02-28" version="1">MFDLPPGSTLPAFLRILSFASFSFNPGQVADWAQRLKTRKILHLGFDNIPEVCSLVDQLSGSVSNLRSFAIRGPAPANRDFNPGIIKSLDLFLRQITKLHSFEAYDWPKDVLRSVGLYHGNHLRQLRFHHSGFAFRCPPGLNGSRFDICRDARALSRLLISLLSPEELTCLSSELPFVERLGIDLCFIGSMPCDILSGVASFENLKALELLTPDGVGFVPKNAKPDMPPFPWLDASITEEAFRYVAAQKVLQHRPAANNHSMPSWPQLIQLDITADCWGLTSVKYRVERLLDGFLPVSWWDPRSSMNVRSIQVYPNTKKLSKFAGFTEDTVYEMPMYSSGLWDSRNADFEMSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0A3</accession>
    <name>A0A2I2G0A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_449784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701613.1">
        <property type="nucleotide sequence ID" value="XM_024851069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0A3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0A3"/>
    <dbReference type="GeneID" id="36558768"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449784"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF17">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="292" mass="32952" checksum="E112FD4AA26B5AED" modified="2018-02-28" version="1">MVPMDDSYNGWRCFILPFACADGMVMDAVSAVSAFHICEKGGRHRDHRPDKFYAKVISGLRSRSTLKECDLETRQSVFLAIIVLLVGVMVNGSSDFPILFYMLQSALEAVGGESGLGDGELTRFLMRQIRKMRVYAAPLLSQEAGVQTILSSAQKSFDCLYFNSGLHPDHSSTFDLIVGLRQQAYDIYLQRAMLGRRNIRHVDRIGRFIDTLQSLPDTAPGQHTLIWPSFIAASESCLPEHQLFFKQFLEKQYLLNGFSNILKALTLLERIWASENSDSWPSLLPESRVFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0R5</accession>
    <name>A0A2I2G0R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_457102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701760.1">
        <property type="nucleotide sequence ID" value="XM_024851681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0R5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0R5"/>
    <dbReference type="GeneID" id="36559380"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457102"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="517" mass="56872" checksum="B8DDE25697429258" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G101</accession>
    <name>A0A2I2G101_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_363672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701867.1">
        <property type="nucleotide sequence ID" value="XM_024844594.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G101"/>
    <dbReference type="GeneID" id="36552294"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363672"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1090"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1132"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1177"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1332"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="50"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="731"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1362" mass="152607" checksum="C77F68066C39647F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1E6</accession>
    <name>A0A2I2G1E6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_219454</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702003.1">
        <property type="nucleotide sequence ID" value="XM_024842853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1E6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1E6"/>
    <dbReference type="GeneID" id="36550552"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_219454"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45768">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF13-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45768:SF18">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL47-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="290"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB46701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="450" mass="49827" checksum="583476DC6C2F6FE6" modified="2018-02-28" version="1">MAAASLTTAASLFTGPEVATNNTPLVNDSATFRLALDGTVQTLSTQNAPDKGPIKGLFFVPGLDDSDPCTNATAQYVPANVTRFEDVKTFGYRTVGLAPWISADCTQSFLDSSRRVGTNALVFFIPSSNDTKPPAEDSSVWSLRDREWKRRNKYPVYAIPGPAGATIMRQLSWYSGNPNRSHNDSTEFLQEGQGETRLFALINIDKGGKKMPSLWGFILAIVGTVLVLSVILLLCYQIVQKRRRESLQRRIEAGEADIEHLGLHQVKVSQEILDTFPVYAYPDLEALSDRDVESRSGDGISMQPLDKVEEEPEESHTESETQIRTDEAVGDIQKGGKEAEEQEVCPNQRDDISASSERQTPTTAPFFRNRLSHSQTTCAICLDDFVPNVAIVRELPCGHIFHVECIDTSLDQNSSLCPLCKKNVVPPGSYPVPVTNRMVHLDYMLRRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1Z1</accession>
    <name>A0A2I2G1Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_448629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702202.1">
        <property type="nucleotide sequence ID" value="XM_024850979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1Z1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1Z1"/>
    <dbReference type="GeneID" id="36558678"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448629"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="468" mass="51407" checksum="23D99AE4932C63AE" modified="2018-02-28" version="1">MPPPSLIPLESICNVRLATSDPDSSWNITFDRPNNHDNNDKPLALPTLTHPHIHLDKAFVHSALSSASHLPSTGSFQEALSLTAQAKAGFHRSDLLQRGEWLLAESVASGVTAMRAFVEVDHTVGLTCLDAGVELKTRWEAACQIQLVCFAQDPVFSGEFGDENRALLEEALARYPQVDVIGTTPYVEAGEAAAKRNIDWAAARALELEKHVDFHLDYNLDGGREALVWYVLDALRRNRWTASTTNKRVMLGHCTRLTLFDHEEWSRLAREIHQHDLPVSFVGLPTSDLYMAAPPGAESDNGRPRGTLPVPEMIRKYGLDAVMGVNNVGNAFTPWGSPDPLSLACLGVGVYQTGTQADANLLYECVSTRARTAIGLSSRTSDLVLKHGDCDDVLLFYNVDDTGCGVSRQRTRVADVVWDPPARVSRSVVIRGALKRPPHSVCPDTARSMIEAMYSFCKKQGVTERESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G200</accession>
    <name>A0A2I2G200_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribosome biogenesis protein Ssf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_466279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702198.1">
        <property type="nucleotide sequence ID" value="XM_024852405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G200"/>
    <dbReference type="STRING" id="1392250.A0A2I2G200"/>
    <dbReference type="GeneID" id="36560103"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466279"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="34"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="450" mass="50471" checksum="036D353FD41FB50B" modified="2018-02-28" version="1">MAKGRTKKRTHVRAQNASASARGGGASMSKAPKSMVIRVGASQVGSSVTQLVKDVRLMMEPDTAVRLKERKSNRLRDYTSMTGPLGVTHLMLFSKSATGNTNLRMALTPRGPTLHFKVESYSLCRDVEKAMKRPRGGGQDHKTPPLLVMNNFNSPNADENSRVPKRLESLTTTVFQSLFPPINPQATPLSSIRRVMLLNRELSPESENKDEEDSYVLNLRHYAIATKKTGVSKRIRRLDPKEVRNKEKKGAAVPNLGKLEDAADYLLDPSAAGYTSASETEMDTDAEVEIAESTTKKVLTKRELQRMKAGEKDKAQKKLNATPGVEKHAVKLVELGPRLRLRLMKVEEGLCEGKVMWHDFISKSQEETNAQEKNWDQKKKEKEARKKQQKENIEKKKQDKAKARAEGKGGDDEEDEDDEDDWLSDDFDEGEGTEDKDDVENDDDDDSMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G215</accession>
    <name>A0A2I2G215_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_448635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702209.1">
        <property type="nucleotide sequence ID" value="XM_024850980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G215"/>
    <dbReference type="STRING" id="1392250.A0A2I2G215"/>
    <dbReference type="GeneID" id="36558679"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448635"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="217"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="492" mass="54760" checksum="372C52AD262D5614" modified="2018-02-28" version="1">MGDTPVNGEQPHSYFFDHLTSYPVVSDSITVFKSNKYGAKSLAYADQGYVYIAKPFIPYLSKPYGFVAPYVARVDSLGDLGLTKIDSTFPFIKQDTETLRATIHDGAYFPVRLVGDAKVHVFDLYGSEYKKCGGDGVLARGKAVITTSLVLGQESLGFVSSLLQKKKAQVKDAPDSHVSAENARRRRRTDNASSDSEDGEDDDARAPSSTDVTVKKLVRLALASEYSRLPIRRTDIATKVLGDQGSRQFKTVFNAAQEALRTSFGMELTELPVKEKVSIQQRRAAQKVERTSSSNKSWILTSTLPAAYRKPEILPPTKAPLEGTYTGIYSFIIALILLNGGSLPEQKLDRYLRRTNAETYTPVDRTDRLLQRLCKEGYLVRVREMDGGEEVIEYMVGPRGKMEVGAQGVAGLVRQVYGRQDPREEDTTPAERAQMEEFELRLARSLGLRKPSRRVDEDRTGDENGADTPQRGQTQRQSQRQAAESDEEDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G280</accession>
    <name>A0A2I2G280_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative mitochondrion biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_457396</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702292.1">
        <property type="nucleotide sequence ID" value="XM_024851715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G280"/>
    <dbReference type="STRING" id="1392250.A0A2I2G280"/>
    <dbReference type="GeneID" id="36559414"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457396"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="718" mass="80698" checksum="DF721EA62F7B6F24" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2D0</accession>
    <name>A0A2I2G2D0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_448724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702336.1">
        <property type="nucleotide sequence ID" value="XM_024850988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2D0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2D0"/>
    <dbReference type="GeneID" id="36558687"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448724"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14052">
        <property type="entry name" value="PTKc_Wee1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000536">
        <property type="entry name" value="Cyclin-dependent kinase WEE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000611">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="698"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1070" mass="116740" checksum="8BB8BCC9A85359FE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2S9</accession>
    <name>A0A2I2G2S9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_428392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702478.1">
        <property type="nucleotide sequence ID" value="XM_024847837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2S9"/>
    <dbReference type="GeneID" id="36555536"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428392"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014172600" evidence="2">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="255" mass="28284" checksum="F866116E62863759" modified="2018-02-28" version="1">MRSAIAISPVAALLATLLLLLRVTSAVPVTTEIAVRAPTPTEKEVISVSFYVDKIKEMNLVSGKTCLFYFRLNGAEGEDTARNWYRKYGPAEKGSLSPGSKKKDPVTYMDAAPSLFSYRLSMPAMVSTPPNMKNDKTAGDKITSRWIANGLVSQAVAESCEGDAYFFTPEGTDWTEVYPYKASQTNFWWDFEWPALLKNSKVNNVYQIDPTKATEVPKEPISTKGKVANQEYQPDKNRPLATGWEYDPNKAETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Y5</accession>
    <name>A0A2I2G2Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_237057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702537.1">
        <property type="nucleotide sequence ID" value="XM_024842928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Y5"/>
    <dbReference type="GeneID" id="36550627"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_237057"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="115" mass="13590" checksum="379B44CCC4C4CD11" modified="2018-02-28" version="1">MLEDSLTTTRIHWKIDNSTETPNHLTPLVLLLISPSFSFSSSLRQSTPSGVEIFVPMPIAWLRNFFSRFSDLRRQRKRPRSHSQRVRDRERELRRRREGPTKFNNRGGNIVVVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3A0</accession>
    <name>A0A2I2G3A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_511972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702656.1">
        <property type="nucleotide sequence ID" value="XM_024854946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3A0"/>
    <dbReference type="GeneID" id="36562652"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511972"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="475" mass="51378" checksum="67BF6BA819D14A6B" modified="2018-02-28" version="1">MPPKFLNAPGKLRLYSPFVQNIVMGCVLFCLPGIYIALTGLGAGGGQASSQETTALANSILYGVFTVAGWCAGPVLNHLKPKWTAVIGAIGYPVYVGSLWYYDRAGGQVFPLLAAALLGICAGLLWTTSGCIQFAYPEEKDKATYITLQCILQSSGSTVGALVAFGVTMNGGQESGVSSAVYIAFILVMAVAIVGAAIFIVDPEDVVRDDGRHIATFEKPTVKREILGVLSVMTDPKIIIMLPAMFVAEMCLAMVSSVNAYYFNLRTRSLNNLLFQAVMIPTPLILAYILDNKHVKSRRLRGVMGTTFTSLITMGATCGLLPWVIRNQVDRERPSAVDWTDSSSAAAMALYILFGIVYACFQIGVQWTLAALTNDPALCARYSGASKGTVSLGMCVSFTVDSQGMSFRNQVIMQLVLYCVGICSLYYVIIVYVRQTNYFVEESVIVPTGMENVLDGIEKDDGTQRRVEENEQRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3U5</accession>
    <name>A0A2I2G3U5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_409678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702841.1">
        <property type="nucleotide sequence ID" value="XM_024846798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3U5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3U5"/>
    <dbReference type="GeneID" id="36554497"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409678"/>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="660" mass="74832" checksum="A578150D0E9D1E0F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G448</accession>
    <name>A0A2I2G448_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702941.1">
        <property type="nucleotide sequence ID" value="XM_024849364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G448"/>
    <dbReference type="GeneID" id="36557063"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437431"/>
    <dbReference type="OrthoDB" id="4476860at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014128271" evidence="1">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="106" mass="11659" checksum="AF32319FF3049EB0" modified="2018-02-28" version="1">MHFLKLIYASLFATLAASATIKVDTQPPSLDRCWDAAKNIDELLNLYAQHGDSWMGSSRDAIGHILQSIAEAGTTIKQDCDKLQTIGEQSSYQEEEQNAGNLFGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4G1</accession>
    <name>A0A2I2G4G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_465341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703072.1">
        <property type="nucleotide sequence ID" value="XM_024852316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4G1"/>
    <dbReference type="GeneID" id="36560014"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465341"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="294" mass="32591" checksum="0CFC12436E8955F1" modified="2018-02-28" version="1">MDPGSFEPEGEEQPRTDAAAAEQYEGRAMCPAERDEDDTQDEVGICGNSSSSWVGGFRLLNIGSSIKKSGDFVRASEGGRKKKYHEMAVEVQVASGRQQQLVLTTITRRQTRLRLTGIPGDGPGCGVGDGFWRKRARLEKMKMRQSPREQGGEMWRERGREGRGKRTEKKKAKSRKTSARGTVSDGENERDMRQSVGSRRANQGTAALLVRWIRDDGAAGAAGKVVDPWHLMDSFIHSSCILVRSGYHHGKMAWIRATPLVCGLKEKVLVGRNPENRPPSTADAQWNTNWHVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5H1</accession>
    <name>A0A2I2G5H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_437824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703419.1">
        <property type="nucleotide sequence ID" value="XM_024849455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5H1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5H1"/>
    <dbReference type="GeneID" id="36557154"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437824"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="75"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB48117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="455" mass="49445" checksum="82F0C9C09216C3AB" modified="2018-02-28" version="1">MSPPASSSSSSSSPSSSSSSSSSFATAARNRLASLSSHIMGSNSPSVFSTAVVSAAPEDPLFGLAQAFRQDPDDKKVDLVIGAYRDDYAKPWILPVVKKADELIRTEGYDNEYLSIKGLAGFTDAAQKVIIGPDSPAIREKRVSTLQTISGTGAVHLGALFLSKFHPANPKPQIYLSSPTWANHHQIFTNVGLTLADYPYFDKKTKGLDFAGMTSALRSAPSGSVILLHACAHNPTGVDLTQDQWKEVATIMRQGNLFPFFDCAYQGFASGDLNRDAWAVRYFIEQGFELVIAQSFAKNFGLYGQRTGAFHFVSAPGAEAQQANANVASQLAILQRSEISNPPAYGARIASRVLNDPALFAEWEADLRTMSGRIAEMRSGLRQRLESKGTPGTWAHITDQIGMFSFTGLTEPQVKLLREKWHVYMTKNGRISMAGLNTHNIDYFAEAVDSVVRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G767</accession>
    <name>A0A2I2G767_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_455630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704028.1">
        <property type="nucleotide sequence ID" value="XM_024851548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G767"/>
    <dbReference type="STRING" id="1392250.A0A2I2G767"/>
    <dbReference type="GeneID" id="36559247"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455630"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="362" mass="40665" checksum="9B62252CC6B9F439" modified="2018-02-28" version="1">MMPSDEMASSKVRRAHRKTRTGCTNCKRRRIKCDEQKPSCSKCIQRGFRCGYLTRHPECDSPVAAATDSPQPPAPTHELPMRELQLLHHFTTSTYATLSPRGHVKTIWRVTVPKLAFSSDCLMRAILALSALHLSRLEGDLDHQAHAIGYYDAALRSSTLAMLNISPETCSALYVCSELIFIFHLVHPYLSGNPLLSPNNEVAPWLVLLRGIRTIADPFRDALLTGVLGPMFGTEPSTPDTVIMDSLDTFTAHLRKTHPEADSDLHAYLVAIEELRRWSAGVDGHGFQWAVYVDESYISLLRQMKPAALVIFAHFARVVKKSDSNYWVHGWADRLVGVVYGTLDESYRLWIRPVLEEMGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G840</accession>
    <name>A0A2I2G840_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_356875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704315.1">
        <property type="nucleotide sequence ID" value="XM_024844181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G840"/>
    <dbReference type="GeneID" id="36551881"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356875"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF319">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="245"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="432" mass="46149" checksum="6087E93EAE5C6544" modified="2018-02-28" version="1">MTTVTSEPTVSLTDEKVEQNSSIQPQIDKEDAEFGPAPDGGMRAWLVAAGGSCLFFCCLGFSNSFGAFQEYYLRNQLRGESPDRIAWIGSLSVFLQFGAGMIGGPLFDRFGAKVIRPAAVVYIFAMMMLSLCKTFWQIILVQGVLMGIAMGLLQIPACAAVFQYFDKKRAVAIGVVVSGSSLGGIVMPIAISKMLNNSSLGFGWSVRIIGFLIMPFMAFAIVTVKARLPSRTTKFWISEAYQDPKFIILIISMFFTFIGIFTPIFYIPTYAVTRGMGPTLAGYMPAILNAASTFGRIIPGLLADKYGRLNLFALGGIVTGVIIFCMDSATTNAGLIVYSAAFGFTSGSIISGASAAISLCTQDPRDMGTYMGMGTAISALGVLIGPPVSGVIVEHYQGFFEVSMISGAMCLFGGFVGLMTKLATPQGMFGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8X1</accession>
    <name>A0A2I2G8X1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Beta-galactosidase</fullName>
            <ecNumber evidence="4 9">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_495189</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 9"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704638.1">
        <property type="nucleotide sequence ID" value="XM_024854082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8X1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8X1"/>
    <dbReference type="GeneID" id="36561787"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_495189"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014193665" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="12">
        <location>
            <begin position="377"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB49336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="987" mass="110052" checksum="2E668B83154B3BAD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8Y2</accession>
    <name>A0A2I2G8Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transcriptional activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_509901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704641.1">
        <property type="nucleotide sequence ID" value="XM_024854721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8Y2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8Y2"/>
    <dbReference type="GeneID" id="36562427"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509901"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="733" mass="82579" checksum="BDAC05A81686A4CB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G910</accession>
    <name>A0A2I2G910_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative bifunctional diaminopelargonate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_436950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704672.1">
        <property type="nucleotide sequence ID" value="XM_024849258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G910"/>
    <dbReference type="STRING" id="1392250.A0A2I2G910"/>
    <dbReference type="GeneID" id="36556957"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436950"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001677">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000122">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="794" mass="86592" checksum="621579DDA98A2D87" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G940</accession>
    <name>A0A2I2G940_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein, Mpv17/PMP22 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_436972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704696.1">
        <property type="nucleotide sequence ID" value="XM_024849264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G940"/>
    <dbReference type="STRING" id="1392250.A0A2I2G940"/>
    <dbReference type="GeneID" id="36556963"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436972"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="188" mass="20923" checksum="29E1B6654CD42631" modified="2018-02-28" version="1">MALPAVVKASLQSTLINAGSNILAQGIQAHQNQRPFELDRQALWLFTTCAFLMSPLTFLWLEGLESALPGSYEEKSAPKSKTEKGKDQKPRSRLNVKNIAAKVVIDQTIGGAYNTFLLIALMGYLRGEDYGTIMEQVNNEFWPLLFAGMKLWTFVSILNFTVVPTDKRMLSGSLFSVVWAIYLSLRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Q5</accession>
    <name>A0A2I2G9Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_426492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704908.1">
        <property type="nucleotide sequence ID" value="XM_024847709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Q5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Q5"/>
    <dbReference type="GeneID" id="36555408"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426492"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="116" mass="13061" checksum="564F25AD41DB55A5" modified="2018-02-28" version="1">MSAQNSAGIQTLLDAEREAQKIVQQDRTKRVRDAKSEAQKEIEEYKNQKEAEFKKFEAEHSSGYKKAEDDSNKEAEVKLQEIKDAGSNKGSKVVDDLIHATVDVKPEPSEKILVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAK0</accession>
    <name>A0A2I2GAK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_133678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705211.1">
        <property type="nucleotide sequence ID" value="XM_024842430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAK0"/>
    <dbReference type="GeneID" id="36550126"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_133678"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="69" mass="7893" checksum="3D7C67C88ECCD268" modified="2018-02-28" version="1">MASGRREQGFIVRQDRCYQSDPTDPNNLRHVADPPFSVAYENRSRAICHSFIYLYLLSSFPAIPYLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAT3</accession>
    <name>A0A2I2GAT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_445402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705293.1">
        <property type="nucleotide sequence ID" value="XM_024850705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAT3"/>
    <dbReference type="GeneID" id="36558404"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445402"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF27">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="26601" checksum="9900C9F1C5F314A6" modified="2018-02-28" version="1">MVQSQTKIGIFFIVGALAQLSGYTSRLFLSQDVCNHTAYGIQSALLLLGPTLIMFSVVLTQTEFAQNLDAGKHCFIPLKWQRSLYLVVNTVLAIIQAAGGILTVSRTSHSFINRGTKITIATYIIQTLFWSFTFAENIYMTAKFTQHPTAASSSLFPSWKAWNQLIGLAVSIIAFGRNIMRLTMAGGIDFLVQNGWPSYAFDGFQMGVVLGAWAAWYLPGRCREVAAGMEFMGLEGRGGGSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBF9</accession>
    <name>A0A2I2GBF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Translation initiation factor eIF2B subunit epsilon</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_463481</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705521.1">
        <property type="nucleotide sequence ID" value="XM_024852172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBF9"/>
    <dbReference type="GeneID" id="36559870"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463481"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000053">
        <property type="entry name" value="Probable translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="13">
        <location>
            <begin position="516"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="435"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB50219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="701" mass="77866" checksum="856646E9F70A0A38" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBI0</accession>
    <name>A0A2I2GBI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_445592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705542.1">
        <property type="nucleotide sequence ID" value="XM_024850725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBI0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBI0"/>
    <dbReference type="GeneID" id="36558424"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445592"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="733"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1216"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1267" mass="142020" checksum="009DAFF2B4B783F2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCC8</accession>
    <name>A0A2I2GCC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_435734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705840.1">
        <property type="nucleotide sequence ID" value="XM_024849009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCC8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCC8"/>
    <dbReference type="GeneID" id="36556708"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435734"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="415" mass="46938" checksum="9CC4313423770F1D" modified="2018-02-28" version="1">MGHLERCHHVESQDEENSAYRSWVSVLVWCAIGYLCMITLFVAACFSKPSWLELGLLPVLVRGGPLSPFFAFSRGSERFQKPKGLDIIALVPFHHHERTAVLECYLQRNLAYNHGFLDQVIFIPRTNHTDSLEWLASTVDGTPLYATWKSGDSLASSQQGKEVLYIWIDGDMVFLEDHTIPTVVKTKLDHPDSIVVSANVINAAALQALHSHPGLALPYLPELLPEASKMPSRPTLPQDWRTSKLPQWDGPANFSVLKGFSPPSENHRWLLSSDNGADRTPIGTSVYTDQGPGLDHWTVHAQQHYSFLHHLEAGDLYRYKFPIWKNPNEAISQSFLCFRGEEYDLFRPFVQHEHAKGPPSKMTRETRDPNRKIIIDGKGLVVHYTMGTTSEGLETTDILHRYRAYAQEKVCLNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCY3</accession>
    <name>A0A2I2GCY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_435891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706009.1">
        <property type="nucleotide sequence ID" value="XM_024849040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCY3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCY3"/>
    <dbReference type="GeneID" id="36556739"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435891"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051106">
        <property type="entry name" value="RNA-bind/splicing_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028">
        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN RZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028:SF4">
        <property type="entry name" value="SC35-LIKE SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="138"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="36211" checksum="4E10B905DDBB66BB" modified="2018-02-28" version="1">MHHFHRAATRLISSAASAPARSSWAFAPRSSPSVFLPRLSQPLSQYRWNSNNAPSQPEPPKQEAVEEQHNSNEQLIDATLQYVEGSSEKTGEIATEAEHLAAQKKPDLPIPESNRDSVKEHRHQKLKARATGTLEPKETVFVGNLFYDVTASDLRKQMEKYGVVERLQIVHDDRGFSRGYGYVMYDTIESARRAIDAMNWRVYEGRYVVVQFAQTNMHQFSKLRPVSRTLYIGNMAFEMTDRDLNELFKDIVNVMDIRVSIDRRTGKPRGFAHAEFTDTQASRKALEILSKKAPYGRKLHVNYADDGRSVTSGGPGNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDD6</accession>
    <name>A0A2I2GDD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_493056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706201.1">
        <property type="nucleotide sequence ID" value="XM_024854038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDD6"/>
    <dbReference type="GeneID" id="36561743"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_493056"/>
    <dbReference type="OrthoDB" id="4482926at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014126855" evidence="1">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="185" mass="20531" checksum="355E9812A6D21B9C" modified="2018-02-28" version="1">MKLSFISLVSSLTAVLAVKDYTTNFDYLDLGPLKQNPLRDLEYGDEFQVGAYSVQASNAKTNGKRLLFSGPTPVYKPFGSMKVAVDDVFTVKTIKLGCSGPKQNGKKETIPCDVEVTGMRPSLNEVYKKVSYTKTGELTEVDLEDDFWDLRSLSFRVIAAGQNGDVKDDVTLLLDNFNYFVGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDR9</accession>
    <name>A0A2I2GDR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_406501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706315.1">
        <property type="nucleotide sequence ID" value="XM_024846631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDR9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDR9"/>
    <dbReference type="GeneID" id="36554330"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406501"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014199121" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="361"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1028" mass="116195" checksum="B3D2B470CF12C81D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDY6</accession>
    <name>A0A2I2GDY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_436127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706353.1">
        <property type="nucleotide sequence ID" value="XM_024849091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDY6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDY6"/>
    <dbReference type="GeneID" id="36556790"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436127"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000055">
        <property type="entry name" value="Probable small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB51051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="88" mass="10006" checksum="91872BD1AD9C19E7" modified="2018-02-28" version="1">MSFQPVNPRPFLQARVGTELIIRLKWGQTEYKGKLESIDSYMNVLLRDTEEFIDGKNTGTLGLVLIRCNNILWMGSADSVEMTDLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GES3</accession>
    <name>A0A2I2GES3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_474936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706697.1">
        <property type="nucleotide sequence ID" value="XM_024853201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GES3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GES3"/>
    <dbReference type="GeneID" id="36560899"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474936"/>
    <dbReference type="OrthoDB" id="4779287at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="25557" checksum="4D5B13B460A16DD1" modified="2018-02-28" version="1">MVSYDPPYGFPLRRNGSCLSTETSCGRTWDSFHACCPGESICPGASKAIQNNVCCPSEADCTAPLKESPHCAVANATMFNHTGFFCCLSGQTGFWTDSPKDAVGCSDGVPDDRGYSILNPISFSVSGTATIPSTTSTASATSASSAPASATTTSPSDASDSTGSSSNHAGAIAGGVVGGVAGVAIIVALFLYLFRRRQKSQSIPPQAGEAAAVHPYQNLSPGELHGHTAPAELDNMKDHQIHELPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GET1</accession>
    <name>A0A2I2GET1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase Ure2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_425571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706639.1">
        <property type="nucleotide sequence ID" value="XM_024847645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GET1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GET1"/>
    <dbReference type="GeneID" id="36555344"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425571"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="224" mass="26120" checksum="0DC4B3690D14C024" modified="2018-02-28" version="1">MSSDLQPITLLGKSGPNPLKVEILLRELNISYTVNPVPFSEIKQPEYLAVNPNGRLPSIQDANTGLTLWESGAIFEYLIEKYDKEHRLSFQPGTPEFYHAKQWLYFQTTGQGPYYGQMTWFKKFHAEKVPSAEERYINEIKRVTGVLESHLEKQREKFGDDGVWLVGGKLSFADLAFIPWQRMTVMFLAKEEFDDEEFPIVKGWMKRMVDRELVKKTMEENKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF49</accession>
    <name>A0A2I2GF49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_471448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706816.1">
        <property type="nucleotide sequence ID" value="XM_024852840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF49"/>
    <dbReference type="GeneID" id="36560538"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471448"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="539" mass="61550" checksum="8552A7594AC5C98C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFN8</accession>
    <name>A0A2I2GFN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_83456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706998.1">
        <property type="nucleotide sequence ID" value="XM_024855405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFN8"/>
    <dbReference type="GeneID" id="36563112"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_83456"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="89" mass="10359" checksum="6768D2C106DB1F19" modified="2018-02-28" version="1">MTIYLFHCVPSRVFLFFCLFFFFSFFLGTVVFALMISFLFYSYPIFWVVLVDSFPVVAFAVSYTFLPLFPLSLPNPRALACCHSVRLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGR5</accession>
    <name>A0A2I2GGR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_401932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707371.1">
        <property type="nucleotide sequence ID" value="XM_024846396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGR5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGR5"/>
    <dbReference type="GeneID" id="36554095"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401932"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="146"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="462" mass="52509" checksum="9DBB94342CB65CD4" modified="2018-02-28" version="1">MAQPTSNPDVCNYWGYSFRWTDLHSSPEQLRPMMFTYDKLADECLERLDEISPPQSTPRSATAQPEGSKRPKRDLYSLLKEHAPEDPKLGELWTEINTVPEWVDWNQIKRGQEVFFRYGLPILNVLSFESLLGGMGSGRVVETLTRTGGFSADVVRRRLLETLQHILQVSLSLDSMKPGGEGHISSVRVRLLHASVRSRILALVKQRPAYYDIQQYGIPISDLDCIATINTFSTSVIWVGLPRQGIWLRGQEIDDYLALWRLVAHYMGTPTEAFRSRDTGRAIMESLLVSEINPTDVGKVLAQNIILGLENTAPTFASKEFMEAMARHLNGHLLSDRLDLPRPSWYYRALIYGYCFVVMGACYGVRLVPVLDRLCIALRRKFYYALITDKKEGLGGESFFEFKYVPFYTRTTKLGKRRHIQATQYGIENLAQLGLLAALFTGVALFCGTVFGLRMLTREIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGT1</accession>
    <name>A0A2I2GGT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_349856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707390.1">
        <property type="nucleotide sequence ID" value="XM_024843766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGT1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGT1"/>
    <dbReference type="GeneID" id="36551466"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349856"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="413" mass="46616" checksum="702C6523427ACA08" modified="2018-02-28" version="1">MSTHPYQALPIDDRVKRVLLTTPLIDGHNDLPQQPRAIFHGKIHNNPKFDFEKGFQRGMTDIPRLREGAVGGQFWSVCVPCLRSAENFSTPEYSDMARDAIEQIDLTLRLVESYPEVFALVEGPDDVKRVYEEGRIACSIGIEGLHMAGNSIGIIRAFYRLGVRYCTLTHVCNNVFADSSTSKVGPVHGGLSQLGRSAVVEMNRLGMIIDCSHVSEPCARQVLSLTRAPVMFSHSNAKSVFNCPRNIPDDILDLIRTNGGIIMVTFVPEHVAHRRKDATLDMVLDHLFYIANRIGWDHVGLGSDFDGIASVITGLEDVKCYPRLLERILDRGATEEQLGKVVGENLLRVWRGVERVRDRMKQEGVLPVEDVWDDRTWWRYDGYYQMPDPDPEDKLGLDWYGVPPPEEGLYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGZ3</accession>
    <name>A0A2I2GGZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_453634</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707452.1">
        <property type="nucleotide sequence ID" value="XM_024851375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGZ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGZ3"/>
    <dbReference type="GeneID" id="36559074"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453634"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB52150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="336" mass="36010" checksum="F045AA3DF6A75E45" modified="2018-02-28" version="1">MATKVGINGFGRIGRIVFRNAVSRDDVEVVAVNDPFIEVHYAAYMLKYDSTHGRFQGTVETYDQGLVVNGKKVQFFAEKDPAAIPWGKAGASYIVESTGVFTTTEKAGAHLKGGAKKVVISAPSADAPMFVMGVNHESYKTDVNVLSNASCTTNCLAPLAKVINDQFGIVEGLMTTVHSYTATQKVVDAPSGKDWRGGRTAAQNIIPSSTGAAKAVGKVIPALNGKLTGMAMRVPTANVSVVDLTCRTEKAVTYDQIKEAIKTASEGQLKGILGYTEDDIVSSDLNGDSHSSIFDAKAGIALNEHFIKLVSWYDNEWGYSRRVVDLISYISKVDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGZ9</accession>
    <name>A0A2I2GGZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_351181</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707451.1">
        <property type="nucleotide sequence ID" value="XM_024843845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGZ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGZ9"/>
    <dbReference type="ESTHER" id="9euro-a0a2i2ggz9">
        <property type="family name" value="Arb2_domain"/>
    </dbReference>
    <dbReference type="GeneID" id="36551545"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351181"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="145"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="504"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB52149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="784" mass="87100" checksum="BB2C822F2B535B31" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH02</accession>
    <name>A0A2I2GH02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inorganic phosphate transport PHO88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_453635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707454.1">
        <property type="nucleotide sequence ID" value="XM_024851376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH02"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH02"/>
    <dbReference type="GeneID" id="36559075"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453635"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="187" mass="21022" checksum="872CD03B93BB0AFF" modified="2018-02-28" version="1">MVSPQVTNLVIIVVMMQLAKKVPFEDPDVLMLVRGMYTLSNVLILSLYLYTQTKINSKKDLTTLKYVEPAPMGSNEEPRPVTTTNMEYDKGQLRQLIKGQLMGVGMMGVMHLYFKYTNPLLIQSIIPLKSAIESNLVKIHVFGRPATGDLQRPFKAANSFMNQGQIKSDKASVENAEKNWRGGVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHD1</accession>
    <name>A0A2I2GHD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_402331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707593.1">
        <property type="nucleotide sequence ID" value="XM_024846418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHD1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHD1"/>
    <dbReference type="GeneID" id="36554117"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402331"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="203" mass="21965" checksum="B4ADD6F305FDE2B3" modified="2018-02-28" version="1">MSSNIPSADPYKEKSLEDPPLPQKIEDLVDFISETKFGMLTTKASDSDLLTSRCMALAGKEHGGIDLIFHTNLFSGKTLDLTLHPQETNMSFLDPVSGSWASISGTASIVADPAVVKKYYSPTLPAWFGDLGDGVHDGGPNDPRIGVIKLQATTVTHMAARKGLLGRTVTTIKGAAQGDVPAINSLREFTKEELEEWRRTHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI20</accession>
    <name>A0A2I2GI20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-galactosidase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_352716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707827.1">
        <property type="nucleotide sequence ID" value="XM_024843935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI20"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI20"/>
    <dbReference type="GeneID" id="36551635"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352716"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24043" checksum="E292370EA292CEE7" modified="2018-02-28" version="1" fragment="single">SLPDLPSDDTWNMARISRDPSTGALATKLERKKLPAVEDTWHPKSIDYLSLSRVKQLTANTFEATCSDQDLVTGTGIGTDTVIAKIARFYCEIPRMAQETRIYKSLEGTGLAPRFLAHVHEHGRVIGILLEKLGGREAGIEDLMVCQSALGRLHDIGICHGDVNRYNFIVQGNTARLVDFERSHICPDAASLEDEMESLDDQLRESTGRGGGFRFAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GID6</accession>
    <name>A0A2I2GID6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_434365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707948.1">
        <property type="nucleotide sequence ID" value="XM_024848698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GID6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GID6"/>
    <dbReference type="GeneID" id="36556397"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434365"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="5">
        <location>
            <begin position="91"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="327" mass="36024" checksum="5565C7BC7DBDFD4C" modified="2018-02-28" version="1">MVGNFEEAALKGQSAGGWKSWSTKKKLLVIGSVLLAIIALAVGLGVGLGVGLNNGDNDEGDSGDNETPPTTGGGGNNTSGSVKWKPKAGTTWQIELLYPLNDTSHDVDVYDIDLFTNKKETIDDLHKQGRKVICYFSAGSYENWRPDKSKFKQSSLGSVMDGWPDEKWIDIRSDNVKEVMIGRLDMAVEKGCDGVDPDNVDGYDNENGLDLKKADSAKFMNWLADESHKRNMSIGLKNAGDIISSVINKMQWSVNEQCAQYEECDTYAAFVHKDKPVFHIEYPKGDETNNEVNVSTKQKNKACEFSGSGNFSTVIKNMNLNNWIQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GII0</accession>
    <name>A0A2I2GII0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_378703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707980.1">
        <property type="nucleotide sequence ID" value="XM_024845458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GII0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GII0"/>
    <dbReference type="GeneID" id="36553157"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378703"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="43"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="32671" checksum="CA68B1974074B0AE" modified="2018-02-28" version="1" fragment="single">MATRQWASRLRHMHTSASSSASRIPLAYEVHEPKKHQPAGHRPPIIFLHGFLGSKRENARVSKHLSHDLSRQVYTLDLRNHGDSGHHWRHDYMEMALDVELFIKKQGFESATIIGHSMGAKTALTLALQAPDLVSDVVAVDNCPISLPLPGDFQKYMEGLVEVEQARVKTHAEGERILAKFEKSPVVRLFLLSNFIKDHRHQYLRSRLPLDILKAALGPLGDFPHETSPTKFLKPALFLRSRHSYYIPDSALSQIISFFPRSKIVDITCGHWIVQEKPEEFRQGMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ47</accession>
    <name>A0A2I2GJ47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_434607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708190.1">
        <property type="nucleotide sequence ID" value="XM_024848754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ47"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ47"/>
    <dbReference type="GeneID" id="36556453"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434607"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="254" mass="27779" checksum="0DFD9A06C077CFFD" modified="2018-02-28" version="1">MSGSAGYDRHITIFSDNGRLYQVEYAFKAITSANITSLGVKGKDCAVVLSQKKVADKLIDPSSVSHVFRLSPSVGCVMTGSIADARASVDRARGEAAEFRYKYGYEMPCDVLTKRLANINQVYTQRAYMRPLGVAMTLISVDSEKGPQLYKSDPAGYYAGYKATASGPKQQEALNHLEKKLKNKDYAEGSWEEVVELGITALSSVLSVDFKKHELEIGIVGGPRTDGKEGTDSGFRALTEEEIDERLQAISEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ53</accession>
    <name>A0A2I2GJ53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_349914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708212.1">
        <property type="nucleotide sequence ID" value="XM_024843770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ53"/>
    <dbReference type="GeneID" id="36551470"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349914"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000447">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
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            <begin position="56"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PLB52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="529" mass="57451" checksum="3B9F62B2152E5981" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK18</accession>
    <name>A0A2I2GK18_9EURO</name>
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        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">P170DRAFT_434927</name>
    </gene>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="STRING" id="1392250.A0A2I2GK18"/>
    <dbReference type="GeneID" id="36556533"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434927"/>
    <dbReference type="OrthoDB" id="3946221at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
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            <end position="932"/>
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            <begin position="1049"/>
            <end position="1072"/>
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            <begin position="60"/>
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    </feature>
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            <end position="89"/>
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            <begin position="131"/>
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            <end position="426"/>
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            <begin position="852"/>
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        <location>
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            <begin position="1063"/>
            <end position="1072"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PLB53223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1072" mass="120347" checksum="31353730771C9B13" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK85</accession>
    <name>A0A2I2GK85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_352310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
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                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
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                <person name="Nolan M."/>
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                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="PLB53281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352310"/>
    <dbReference type="OrthoDB" id="3868412at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="79" mass="9358" checksum="2D5A792EE360835E" modified="2018-02-28" version="1" fragment="single">RVWRTGLPVRSAVLKPHAGRLVVGWVTTSESRLLYVFLFYQCFIYFFFFTCGGSIRNRNVEHLSMLYVLQRLLAYYDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKH0</accession>
    <name>A0A2I2GKH0_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">P170DRAFT_348479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024843680.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1392250.A0A2I2GKH0"/>
    <dbReference type="GeneID" id="36551380"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348479"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
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    </dbReference>
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        </location>
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            <begin position="429"/>
            <end position="576"/>
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    </feature>
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        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="576" mass="61485" checksum="05D00A20DFE42DF4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKV8</accession>
    <name>A0A2I2GKV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 8">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_490714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 8"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708824.1">
        <property type="nucleotide sequence ID" value="XM_024854005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKV8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKV8"/>
    <dbReference type="GeneID" id="36561706"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_490714"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000005">
        <property type="entry name" value="Arabinan endo-1,5-alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014129646" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB53522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="34186" checksum="BFA6B077388F7772" modified="2018-02-28" version="1">MYTSLSLLPLLYALAHGYANPGACSGACNIHDPGLIQRASDGKYFRFSTGNKISYASASSIEGPWEAIGSVLPGGSSIDLEGKDDLWAPDIQKVGDLYHLYYSVSTFGSQNSAIGLATSSSMDANSWTDRGATGVRSDSSKNYNAIDANLFNDGGTYYMNFGSFWGDLYQAPFNAAATKVSSSSYNIAYDPAGDHAVEAAYLYKNGNYYYLFFSTGKCCSYDTDRPATGEEYKIKVCRSSTATGNFVDANGVSCREGGGTVVLESHGNVYGPGGQGVFTDSENGPVLYYHYVDTTIGYGDGQKLFGWNKIDFSSGWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLK2</accession>
    <name>A0A2I2GLK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_420567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709056.1">
        <property type="nucleotide sequence ID" value="XM_024847301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLK2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLK2"/>
    <dbReference type="GeneID" id="36555000"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420567"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="361" mass="42121" checksum="007938D064B54051" modified="2018-02-28" version="1">MVSFEDYRASMLRTLKGQTIRVPDLVALIYPDWQVERHEFEPQIRLDLCDSFVARWYPENDRRQKLVKSGFETIAGYFCTGCQSERFLTLAQFMYWLFIWDDEIDCGDLTKDEAGTQNYHRDTIIFLKSCLEPGGLDCSQECATLGKHNSKSFKKIGDRMKDGQSKQALNRFAVSVYEYVDSVCDAQKVRITCLPTWEEYLANRLLTIGAHPYLMAMEYAYGVVVPELVYERKEIKLMLKETSISIIMWALGTLFNWNSIKAKWKFAIPLKMHHRGYTYAQDALVEVIEDLSKSRQRFNIAEYLFLESKEYQNMSHTGQDAVKVLIQGCKNMMLGNMKWSFSNTRYTPDERLEGWAVTFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLR1</accession>
    <name>A0A2I2GLR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cucumopine synthase C-terminal helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_451806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709115.1">
        <property type="nucleotide sequence ID" value="XM_024851224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLR1"/>
    <dbReference type="GeneID" id="36558923"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451806"/>
    <dbReference type="OrthoDB" id="4299926at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040602">
        <property type="entry name" value="Cucumopine_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18631">
        <property type="entry name" value="Cucumopine_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cucumopine synthase C-terminal helical bundle" evidence="1">
        <location>
            <begin position="170"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="333" mass="37396" checksum="778BB401BECF15A3" modified="2018-02-28" version="1">MAVGTTLEQPRTIKIHWPKLNIMITAIMTERNPALVNLLFSKLPYRSLQSHALVSGDHLYHLVPAEALIYTHPDHKVPNRALEPDGTVFLSGFQHMAIKYGTLTEDLPAAPCGYVVPEDIEKLKKAGSLLWEACNEASDPIEVIVWDATEAEPKGHIPLTLERTGVTDEVKELVLQIHNETEFSWSGISSDLEIIHQGRATSHAGSKDSYFATMLFINSEIRTLGYYILNNILKTAATQPHFDLEHLISMYRVFVPTPAEFVGYVGAHFLCSTNRKIDAVLTEKVEKMDDQEAAREDFLALMSALAQYVNLLNAQNLQLFPWKHGDEYPVFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLR2</accession>
    <name>A0A2I2GLR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_504726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709114.1">
        <property type="nucleotide sequence ID" value="XM_024854221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLR2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLR2"/>
    <dbReference type="GeneID" id="36561927"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504726"/>
    <dbReference type="OrthoDB" id="2567457at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF5">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22561" checksum="56DD6A062C6AD7B7" modified="2018-02-28" version="1">MSSDPFRRTCLIPYANPDSLPPLLREKLNILPFRRNILYTVAQSRGLGPHFLGLIGACFDGGQRSLPELDWQLIVLRVAKNLDCKYEWDVNVPVAEVHGMPREKIKSIGRTLEDGKGPWTERDRILIRLVDEQLARYTNKEETVRQALGILNEGELVEVLIVIGVYAVLARLIKGLRVDDDPPIRGLKDLIRRSITATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLV4</accession>
    <name>A0A2I2GLV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_396789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709141.1">
        <property type="nucleotide sequence ID" value="XM_024846136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GLV4"/>
    <dbReference type="GeneID" id="36553835"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396789"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="4"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="975"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2506"/>
            <end position="2583"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="975"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1007"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB53839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2590" mass="285584" checksum="666FE280321498E6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLZ8</accession>
    <name>A0A2I2GLZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_347566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709204.1">
        <property type="nucleotide sequence ID" value="XM_024843638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLZ8"/>
    <dbReference type="GeneID" id="36551338"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347566"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="493" mass="54949" checksum="3B08DAC8919B301D" modified="2018-02-28" version="1">MAPSTEKWYHQWAWYERGCPPEEKKLLFKLDASILTFGCLTFFTKFLDLQAFQNAYVTGMKEDVGMEGNDLQYTTGVFQAGYCSMMIPANILLTRFAPNILIPACEVLWGVLTLCTAFVDNVGHVYLIRFFSGAFECVAYPGVIYCIGCWYKRSEISRRLSLFYIAGPLGTMFAGYFQAACYTNLDGNEGLAGWRWLFIICGIITIPVAILGFLTFPARPDSPRPSLILTSHEVSLARRRLESDGNEPPKVRLTLNIFRQVCSSWRPYAFVLLYIIFNQAMITNGQPFNLYLKAHKDIYSESEINTYPTGQSALSIVTALAACYWADVSGKRWLPSLVICFWMTTGAICMAVWYIPVGLKFFAFYVAGLGGALNPLFMSWASEATVRSAEERAVTVACMNAFGQALLAGLNIVTFPTPKAPRFKFGWYWVMANNLAQIVLVVVIMVLHERQKRGEVEVCEGEIVDDDGLKGGGHGEIVKGVDEGDVSRKGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GME8</accession>
    <name>A0A2I2GME8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_397049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709346.1">
        <property type="nucleotide sequence ID" value="XM_024846155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GME8"/>
    <dbReference type="GeneID" id="36553854"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397049"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="57"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="344" mass="39050" checksum="A1DA123EB9B943A6" modified="2018-02-28" version="1">MGLVTRPFVDKLREPMYAATRRLFWDPETMASPTLPLIQAGLLLSVHEYGQGFLSASYMTISVCLSMAQVVGLCPMQSPPPFPGSGSWNSSEEGLRTWWAIVIHERMISLKCGFPIKPLQLGNPDIISNKHLDSEVQNTVASIISNPLHDYFFLQTRAAIWLDMVLEIVQSPSTMSPEGRLHFQLVDRNLLVFLQSLFRLGLGYCCEAIAISLSAFVHLHKWRLTSPSPFFSQQDRFDSSSAIETVLTVLSDLAHHRFQDATPEENAALYREPFPYFIHMVYQAMVELIRLQRTSQTKSDAFQTQMSIIWRTLQSQSSRWKIAGLFSADWSFDMTVDSYTLPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMN5</accession>
    <name>A0A2I2GMN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_8870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709438.1">
        <property type="nucleotide sequence ID" value="XM_024855426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMN5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMN5"/>
    <dbReference type="GeneID" id="36563133"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_8870"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="233" mass="26794" checksum="40B2319FE6669F0D" modified="2018-02-28" version="1">MSSRQWILDRWGPGGIIQIPAENYFHDLEKTQIKLCYAANLEYQLSLIQVQRLMKFSHTVTFVNFGEPMEQVIAAIRFSERFYKRFASQSFQDMKPVISEGTPCAIEWRDETEESPRKCTGMVFLDIFDFPFQSDLIVSVTGRKRTGSKGFLNQYPVSDETRSYPCTLAFETLDDCVRTQINTINTMCSDARKEWHQAILNHEPSALPRVNVFDGIPEDDVAAAYKEIAQLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMW3</accession>
    <name>A0A2I2GMW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="7">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_397369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
            <location evidence="7">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709517.1">
        <property type="nucleotide sequence ID" value="XM_024846170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMW3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMW3"/>
    <dbReference type="GeneID" id="36553869"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397369"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Telomerase ribonucleoprotein complex - RNA-binding" evidence="9">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="120" mass="12951" checksum="6FA6FA4C546613D1" modified="2018-02-28" version="1" fragment="single">MSRDLKSSGAENLITQPAGPGCVLPSTVAETNGDLNTVDVQKPKSNIPKPKLSLTDYATPSSSVSAFCRAVLRKLVSPQWYGVGQQGKSNQGIILKHVDRFVRMRRSESLSIHEICGGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNC6</accession>
    <name>A0A2I2GNC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_505150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709687.1">
        <property type="nucleotide sequence ID" value="XM_024854264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNC6"/>
    <dbReference type="GeneID" id="36561970"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505150"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="79" mass="8327" checksum="70ADC9132B5168C7" modified="2018-02-28" version="1">MDAYLQGWCVGRVAQGGNCGHRMDASNRTGTVSRLSLLAVSVLGRSVSLSLAPVSLSLFAFSLFLCVSRCPGWIPLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNF9</accession>
    <name>A0A2I2GNF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_346794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709724.1">
        <property type="nucleotide sequence ID" value="XM_024843585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNF9"/>
    <dbReference type="GeneID" id="36551285"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346794"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="337"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="46956" checksum="FF3C964E603F7DB0" modified="2018-02-28" version="1">MSDPTNPSIQQRTTPQWGLYQRENFWRVNDGQTVPFNTDPKKLEELAHEKLSQGGWFYASSNAGMSQTHQANRQAFYRHRLVPRQLVDTNRRDTTTEIFGHRVSAPIGFAPIGINQIYHPAAEAAVARVAGELNLPYCLSTAGSTPIETVGAANGPGNPRFYQLYMPHDDELTLSLLTRARDAGFDALLLTTDTWQLGWRHDDVAHSNYAFYRGRGADLGLSDPVFRRRCQDDGIDPDRDVVAASTKWIDSIWHGRAWSWEKIPWLQEQWRRISGGRPFAIKGIQSVADARKCVEYGVDGIVVSNHAGRQVDGAVASLDALESIVDAVGDRIYVMFDSGVRGASDVAKALALGARFVFVGRLWIWGLSIMGEEGVRHVMKSLLADFDILMGVAGFNSVQEFDRSILESYPKMYSLIPDKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNG4</accession>
    <name>A0A2I2GNG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_442520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709720.1">
        <property type="nucleotide sequence ID" value="XM_024850468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNG4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNG4"/>
    <dbReference type="GeneID" id="36558167"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442520"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18538">
        <property type="entry name" value="PFA-DSP_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB54418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="232" mass="25947" checksum="AF5DA7EEEBC6BA10" modified="2018-02-28" version="1">MANATRPLPLTESTANGSPGVQNERQTYRVTSSMEPELLHSELPSNFGEVVKGIYRSAFPHPWNLPALRHLGLKTIVTLVDEPYTASHTTFLEENGIAHFRIPIPANKDPAIKTPDHIMIGILEILLNKANHPVLVHCNKGKHRTGCVVGCFRKLQGWELRDVLGEYLSYSWPKSRALDEKFIEAFDASGLRSLTRTTGAALWQPTKPSEQKERKEKPQRHLIPAPHGVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNI1</accession>
    <name>A0A2I2GNI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">P170DRAFT_432062</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709722.1">
        <property type="nucleotide sequence ID" value="XM_024848180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNI1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNI1"/>
    <dbReference type="GeneID" id="36555879"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432062"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 22" id="KW-0408">Iron</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="24">
        <location>
            <begin position="107"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PLB54420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="498" mass="54534" checksum="BDE699F4C9CF5C2E" modified="2018-02-28" version="1">MTDSKLVSTKQVAEHNTPEQCWIVVDNQVWDVTDFLDDHPGGSNIILKYAGRDATKAYSEVHTPGVLKSNLPPQKFMGVLDESTIDDDWAKGPPAENPQVVLENEKPPLHTLINSYDFELVAAKTASKKAWAFYSSAATDLLTRDANKSCFDRIWFRPRVLRNVRSVEPKTTMLGVDCSLPLFVSPAAMAKLIHPEGERAIARACESKGIMQGVSNNSSYTVDDLREAAPSASFFFQLYVNRDRAKSAALLRQCSANPNIKAIFVTVDAASPGKREADERVKADETLSVPMAPSKAKNDKKGGGLGRVMAGFIDPGLTWEDLAWVREHTHLPVCLKGVMSADDAILAMEAGLDGLLLSNHGGRNLDTSPPSIITLLELQRRCPEIFDRMEIYVDSGIRRGTDVLKAICLGATAVGMGRSMLFATNYGQEGVEHLIDIIKDELETAMRNTGITSLDEASPDLVHTGDVDHLVPRARLHPYARKVAKGRRPASHPSNPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNK3</accession>
    <name>A0A2I2GNK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_373567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709759.1">
        <property type="nucleotide sequence ID" value="XM_024845247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNK3"/>
    <dbReference type="GeneID" id="36552947"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_373567"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014112826" description="GOLD domain-containing protein" evidence="8">
        <location>
            <begin position="30"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="231" mass="25644" checksum="8529FBCFE691A2AF" modified="2018-02-28" version="1">MAPSTSSASWLSSALALCAILCLSVPVNALYFYMDGRQTKCFFEELPKDTLVVGSFSTEVINQQSNTYSVDPNLKVLITVDEIFDNDHRVVSKRDGNSGRFTFSAAESGQHKICLTPETNAATGGWLSGAPGGAVRVSLDMAIGETSKIETEDKGKMQDIVQKVKDLNSRLQDIRREQVFQREREAEFRDQSEATNGRVVRWTLIQLAVLSAACAWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNM5</accession>
    <name>A0A2I2GNM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_347212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709768.1">
        <property type="nucleotide sequence ID" value="XM_024843615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNM5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNM5"/>
    <dbReference type="GeneID" id="36551315"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347212"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF166">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="294" mass="32809" checksum="C831F1FFC3929C66" modified="2018-02-28" version="1">MTRDHLPIKPQPGLDIEEFDIPARDNHPIRVRSYKQSNSANLPLLIYLHGGGFVTGGLETDDESCRAIAADIPLLALNVEYRLAPEHRFPVGFEDSRDVVYWAASPTGQQRLSTNLQKGFILGGTSAGANFTAGIAHLAAHDGLQPRLTGLLFLAGSFCHPDARPAQYRDRILSVDEINDAPGLTRKSIDYFAGSQCAEKYGAPPSDKRLSPLLFESHANIAFRAAFYICGWDPRRDEAFLFDELLTNEGVLTMRYVYKGLPHGFWTTCPDLEESKGWRRDLLEGVRFLLAREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNQ8</accession>
    <name>A0A2I2GNQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_421209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709819.1">
        <property type="nucleotide sequence ID" value="XM_024847345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNQ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNQ8"/>
    <dbReference type="GeneID" id="36555044"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421209"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="375"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="773" mass="85348" checksum="C70CD05E8DF60AE4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNY7</accession>
    <name>A0A2I2GNY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aspartyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_452324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709893.1">
        <property type="nucleotide sequence ID" value="XM_024851257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNY7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNY7"/>
    <dbReference type="GeneID" id="36558956"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452324"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04321">
        <property type="entry name" value="ScAspRS_mt_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="234"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="679" mass="75801" checksum="BE52A5F69A81D6A5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNZ7</accession>
    <name>A0A2I2GNZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_432227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709901.1">
        <property type="nucleotide sequence ID" value="XM_024848216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNZ7"/>
    <dbReference type="GeneID" id="36555915"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432227"/>
    <dbReference type="OrthoDB" id="4509022at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="260" mass="27548" checksum="EC3318988BA83123" modified="2018-02-28" version="1">MNAPHLNHIRYEDPESTDTSSSSNASRDRIIIGVVVGGVAAIAITAGILFVLLKKRKWDRIRRYEERVLAAHAADGTSGHGYKAYGFAPGDLELGDTRASSSLSWTYGGAPQSLEQNPGPGPEPGQHQNQSQSQRQRRESHDSVSPPPAYQPLPVYDPSRYSGIGISTLPAAVKPSWKKGSSRGSLSMSGSGSGANPHRNSTTYIGGLDLPSDQRGGSLGRASPEGPRSMESEGGEASSGQGVRGPRRPKPVLSRLITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPH2</accession>
    <name>A0A2I2GPH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZIP zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_505465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710074.1">
        <property type="nucleotide sequence ID" value="XM_024854292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPH2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPH2"/>
    <dbReference type="GeneID" id="36561998"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505465"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014153189" evidence="7">
        <location>
            <begin position="18"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="499" mass="52621" checksum="0EC91EB97CEB94EB" modified="2018-02-28" version="1">MFRNLFLTAIAVGAVHAQTASYTGCHNHGSVEYCFGPDGEETAMSTQAASTATSVSASTTSSADSAAITGCHSHGDDVYCIESDGSEVQVSMEATPTGEMPAEYTGCHSHGEDRFCMDPDGNEVQVLAEGESTSDSGDSESGDSGGMNCHFHAGVEHCVGEGESEHSSEPSCGVQTRDYDMPLRIGTLFVILVTSALGVFLPMLLVKLPFQKINTMFSTIVKQFGTGVIMSTAFVHLYTHANLMFTNDCLGELEYEATTSAIVMAGILLSFLTEYIGHRILLARSRRNAASSSSPDSPTMTETGSNTQKPTPDAPSHPGASTLAHLGHSHGPHDPTQPNTKLSVLVMEAGVIFHSILIGLTLVVAGDSFYKTLLVVIVFHQFFEGLALGARIAMLPGRILPSKAIMATIFALITPIGMAIGMGVIHSFNGNERSTLIALGTLDALSAGILVWVGLVDMWARDWVIEGGEMLNAPLGQVLTGGISLIAGMVLMSLLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPJ9</accession>
    <name>A0A2I2GPJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_470240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710100.1">
        <property type="nucleotide sequence ID" value="XM_024852728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPJ9"/>
    <dbReference type="GeneID" id="36560426"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470240"/>
    <dbReference type="OrthoDB" id="5405654at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="272" mass="29614" checksum="78BB2DC79984EE6F" modified="2018-02-28" version="1">MPSIKPTLHPLKTPQPMVFPSELQRNPDTGTSLSGNGSGRPGDEPLCTPITPPAAYTEFLKAFTPIFSPDSARGENGRFRFDKPFERSAITNANHYLNPPSATSNPGSGSGNTSAPTSQPASAVSTSFNFNESARSATASLPPPTPYGAPFPRRDPRNLRSLRIPGSGPIPPRYSPTSMSMGESPRSATMLRSPYSPSDWKMRYYEGPRSANSRVSVRHVVTHTVTYKRTQLEDPPKGKKRRKVTEEVTEKETTKSGDEEDEDASSEDSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPY9</accession>
    <name>A0A2I2GPY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_460918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710241.1">
        <property type="nucleotide sequence ID" value="XM_024851985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPY9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPY9"/>
    <dbReference type="GeneID" id="36559683"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460918"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="59"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="527" mass="57891" checksum="91B5AB513BA16321" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPZ3</accession>
    <name>A0A2I2GPZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin and ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_421579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710250.1">
        <property type="nucleotide sequence ID" value="XM_024847373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPZ3"/>
    <dbReference type="SMR" id="A0A2I2GPZ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPZ3"/>
    <dbReference type="GeneID" id="36555072"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421579"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="305" mass="34287" checksum="E6BBBF708CA6276A" modified="2018-02-28" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQC2</accession>
    <name>A0A2I2GQC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 69</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_432613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710375.1">
        <property type="nucleotide sequence ID" value="XM_024848299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQC2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQC2"/>
    <dbReference type="GeneID" id="36555998"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432613"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33179" checksum="7DF882FA5E273C7A" modified="2018-02-28" version="1">MLYRTTAARSALRALSNTNASVARSSFASNVFKAPLTSAARFPARPTSSPSLALAARKPVTTALVRYASSSSKDSHGEEDVDMMAGIKGEAKVIKDTFSLAEVPKEALYLGMAGVIPYLATSMETVYLSYEISRSAAGADGLIFSGQTAELLLHMIEPIQVGYGAVILSFLGAVHWGLEWAGYGGKYGYKRYAAGVVAPAVAWPTLLFPTEYALISQFLAFTFLYYNDARAATHGRAPAWYSMYRFVLTFVVGASIVATLVGREQIANTITSEHSITDKINALLFLKKKEQEELEARRKAELEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQC6</accession>
    <name>A0A2I2GQC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_470506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710385.1">
        <property type="nucleotide sequence ID" value="XM_024852765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQC6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQC6"/>
    <dbReference type="GeneID" id="36560463"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470506"/>
    <dbReference type="OrthoDB" id="10402443at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014181152" evidence="2">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="239" mass="27547" checksum="E1E4596A09C173BE" modified="2018-02-28" version="1">MHFHRGLILLGLSITSVLAAPTPVDAQADGENAVAGVDGHSTRTKWFTKYNPEKRDVENTDDEVSVDGHSTRTKWFTKYPPVKRDVDEVENTDEKASVDGHSTRTKWFTKYKPEKRETESVDDEASVDGHSTRTKWFTKYHPEKRDVDEVENTDEEASVDGHSTRTKWFTKYKPEKRDVENTDDEASVDGHSTRTKWFTKYKPEKRDAENAADDDDASVDGHSTRTKWFTKYKPEKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQW6</accession>
    <name>A0A2I2GQW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_461166</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710553.1">
        <property type="nucleotide sequence ID" value="XM_024852007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQW6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQW6"/>
    <dbReference type="GeneID" id="36559705"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461166"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000030">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000016">
        <property type="entry name" value="phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="108"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB55251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="572" mass="62139" checksum="EA1BC62A1BE9FE85" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR24</accession>
    <name>A0A2I2GR24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1 snRNP splicing complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_399381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710630.1">
        <property type="nucleotide sequence ID" value="XM_024846278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR24"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR24"/>
    <dbReference type="GeneID" id="36553977"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399381"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="31091" checksum="789D93A3F334D635" modified="2018-02-28" version="1">MAAEQRKLLEQLMGADQLIGTGAASRNAQLSITDSKVCRSYLVGTCPHDLFTNTKQDLGPCPKVHSEGLKTEYETASAAEKAKWGFDYDYMRDMQKYIDDCDRRIDSAQRRLEKTPDEIRQTNNLLKQISDLTKTINTGLLEISVLGETGSVAQALNELHKIRTTKHQKETCERELKNLQDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFFGKMHMGYSDMRKGFKKLSEELKGRPPPVRHHDDDDGGWGGRSGGGRGPRYGGGGGYKKRGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS61</accession>
    <name>A0A2I2GS61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAPA-1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_344818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711020.1">
        <property type="nucleotide sequence ID" value="XM_024843485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS61"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS61"/>
    <dbReference type="GeneID" id="36551185"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344818"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="210"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="321" mass="35493" checksum="87DA9117CFB2896B" modified="2018-02-28" version="1">MPSSKLRDATGGTRSGASTRRSVNVFTENPIMSGPRTSRPRKKLVEVNTSDEDDIDDQEEDEVDDEDAPGEDDEDADADGDLDMDDAPPQPAVSKRHAKASTATSKPVKSVEAKEMEMEDDEDEDDEELSEPDSDAEGEPDDLEESGVGNANGGDEDLEEDDIDEEIDSDDGLPSNDPSKMTKRQRGNLGNDFLQLPMEPQVKKHLTAEERQMRRAEMARRRKNLSEKRNEEEKMDTINRLLRKQAPKRRGRIPAAEAAEASADKEAQEFEKADPTMVRWVSGRNGSRVGVPEEWFGTPGGRVFGEGPLGSNGPRKLVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS88</accession>
    <name>A0A2I2GS88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_453020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711041.1">
        <property type="nucleotide sequence ID" value="XM_024851324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS88"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS88"/>
    <dbReference type="GeneID" id="36559023"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453020"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="544" mass="60413" checksum="B52609F4A404B856" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSG1</accession>
    <name>A0A2I2GSG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-requiring enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_50475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711126.1">
        <property type="nucleotide sequence ID" value="XM_024854225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSG1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSG1"/>
    <dbReference type="GeneID" id="36561931"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_50475"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="211"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="422"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="598" mass="63968" checksum="2A1134C444486258" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQI4</accession>
    <name>A0A2I2FQI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">rRNA intron-encoded homing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_371171</name>
        <name evidence="2" type="ORF">P170DRAFT_395228</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000020">
        <property type="protein sequence ID" value="PLB42888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB42990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371171"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395228"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34410">
        <property type="entry name" value="INTRON-ENCODED HOMING ENDONUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34410:SF2">
        <property type="entry name" value="RRNA INTRON-ENCODED HOMING ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="68" mass="7227" checksum="CBDFBFA502E9B7F8" modified="2018-02-28" version="1">MINRDSRGPFAKDVFINQGTKGSDGVSIMTRSAPYEKSKFLGSGGSMVARLKLKEIDGRAPQGVEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQS4</accession>
    <name>A0A2I2FQS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_370738</name>
        <name evidence="2" type="ORF">P170DRAFT_371360</name>
        <name evidence="3" type="ORF">P170DRAFT_486903</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000024">
        <property type="protein sequence ID" value="PLB42837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370738"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371360"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_486903"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00034">
        <property type="entry name" value="Antisense to 5.8S rRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="91" mass="9790" checksum="129335308AB34145" modified="2018-02-28" version="1" fragment="single">IPPGIPGGAMCVQRLDDSLNSAIHINYRISLRSSSMPEPRDPLLKVLTDCDTIDSDDKTSDSVHVGVSGGRSPGGEAPPRRPRGRRARRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRE7</accession>
    <name>A0A2I2FRE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor SPT4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Chromatin elongation factor SPT4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_431142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698481.1">
        <property type="nucleotide sequence ID" value="XM_024848005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRE7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRE7"/>
    <dbReference type="GeneID" id="36555704"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431142"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="13"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="144" mass="16114" checksum="465D5208EC7C28C0" modified="2018-02-28" version="1">MSYYVAPSQQRTLRACMVCSLVQLHNRRLAPRPPSHRISKLTRTPRSSLQKFMREGCPNCDNVLGLRGNNDAIQECTSQVFEGLVTLRDPTTSWVARWQRLDAYVPGTYAVKVTGSLPDEIIASLEDSGVKYIPRDGSTGEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRF0</accession>
    <name>A0A2I2FRF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_441671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698512.1">
        <property type="nucleotide sequence ID" value="XM_024850374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRF0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRF0"/>
    <dbReference type="GeneID" id="36558073"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441671"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="492" mass="54242" checksum="D6D6E6585CADA074" modified="2018-02-28" version="1">MASQSNGAAAQLQRIDSQPENPYSGLITDQSYVVVPSFTLESGVTLHNVPVAYTTRGKLSPEGDNALVICHALSGSADVADWWGPLLGGPGQAFDTSRFFVICLNSLGSPYGSASAVTYKDGKPENGLYGPEFPLTTVRDDVKIHKMVLDHLGIRQIAAVVGGSMGGMLTLEYAFFGKDYVRAIVPIATSPRHSAWCISWGEAQRQSIYSDPKYEDGYYDLEDPPITGLGAARMSALLTYRSRNSFESRFGRNVPDPSKKQNINGTERQPSPPNEHWAIHNDGHKSGRTTPSEQNTPAAQPTEIQYMDPQFSGTKTYSKSLDNNTDAKRQRRPPTYFSAQSYLRYQGEKFVKRFDANCYIAVTRKLDTHDVSRHRASPTSTDPVKEALSQIQQPVLVLGIESDGLFTFEEQKEIAAGIPDSRLKRIESPEGHDAFLLQFEQVNHYILEFFREVLPDIMAKAPADGVEAVDGVNTLTKSSTFGEAEVEDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS20</accession>
    <name>A0A2I2FS20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dickkopf N-terminal cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_514640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698727.1">
        <property type="nucleotide sequence ID" value="XM_024855232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS20"/>
    <dbReference type="GeneID" id="36562938"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514640"/>
    <dbReference type="OrthoDB" id="4491758at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014188023" description="Dickkopf N-terminal cysteine-rich domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29457" checksum="FEED98E9E93BD5F6" modified="2018-02-28" version="1">MNPLTMKLYLLFLGLLVALVTAVAIPDPDKEASGSIDSTSEVANVLYPGQPCKYNWECPSSEHCSKKGRCTLNEGRCLKDKDCPKYMVCSDTHCFPHSRNDRRDSDDSTGSDEAEVVPDIQLKAPCVNNTDCSSNEVCSHGHCTLKTGRCWENRDCNRRQHCINTFCYPPDDLRRRGSGDELADTSNGPIPTPAPVDGSGETEVDETDAETADNMDVTPFEQDTLLGLVKTAANKSGNKCRRRCRYHTDCCPKDLCWNMRVCLGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSG4</accession>
    <name>A0A2I2FSG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB family carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_459252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698890.1">
        <property type="nucleotide sequence ID" value="XM_024851852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSG4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSG4"/>
    <dbReference type="GeneID" id="36559550"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459252"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="37"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="396" mass="43659" checksum="27869E17127C9750" modified="2018-02-28" version="1">MAEETSHGTLPDSHVGFCTLGMFILDDIEFGGIRPDVKNILGGAASFAVVGARLAAGKELARSVSWIVDVGSDFPQEVLNTIKAWDTDCMIREDPGRLTTRAWNGYGHNEKRDFKYLTPKLRLEPHMLSDSQVLSKTFHMVCSASRCISIVQEILRRREELQRGSQASSPLERPIFVWEPVPDLCTPEEQEMFFAANRVVDVVSPNELELGLMFGQSGWCEDEQFGQDIVRRILESGIGPDGAGHLVIRAGKDGSYSYSRAQRIWLPAYHQPAASGSSPVVDPTGAGNSFLGALAQGLVGAGEGPTRVIGSVFASSVNWKDALKANGDRDHILEALVFATVAASFVVEQIGVPRMSTSTEGRELWNETEFTERVRLYTQRLYKSVEESPRKHFQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSZ6</accession>
    <name>A0A2I2FSZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_441211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699065.1">
        <property type="nucleotide sequence ID" value="XM_024850265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSZ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSZ6"/>
    <dbReference type="GeneID" id="36557964"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441211"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="168" mass="18061" checksum="2031C37E59F14494" modified="2018-02-28" version="1">MSQFPSLKPAFTIKVTIDAPLAVGSLSRSNPLQVIPMTGGSFKSDSNFSPSVDSEFVGVGNDYIHADADGKHLRLNAHSVIKTHDGALIYVNYTGIVTLSAAVQAVFSGSADEGSTPFGDAFTHFTFETGDARYKQLEHGVFVAQGRFNVHKDKSIVVEYRVSQVVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT23</accession>
    <name>A0A2I2FT23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_514102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699081.1">
        <property type="nucleotide sequence ID" value="XM_024855173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT23"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT23"/>
    <dbReference type="GeneID" id="36562879"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514102"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="188" mass="20318" checksum="3B0D978E3136F16C" modified="2018-02-28" version="1" fragment="single">AHGLKCSSPSTRADTAHLQGPLASALGLTTWSTLPTQSKPSNIFLRGANRLDGLTLTKASGQNYTHGGSGGDPVKLALKDDEYWTQTTLCQGKRDDHTRIFYLHLTTSAGNELEAGTQTDDCQEFKAPEGWHVVGFYGRDGDEVDWLGFIELRIPVIHHHPNRTSDNKPASAQGGVSEIALIILSAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT74</accession>
    <name>A0A2I2FT74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_430803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699079.1">
        <property type="nucleotide sequence ID" value="XM_024847981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT74"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT74"/>
    <dbReference type="GeneID" id="36555680"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430803"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="304" mass="33137" checksum="F2C4BB70BCE17D65" modified="2018-02-28" version="1">MSILITGATGKQGGAVARHLLARNDMQVHALVRSASSSAALDLRALGANLIEGSFDDAASLQLACQNKTAVFLNVTPSFRNDGAEVRHATNVLLAARAAATVTTLVYPSVSGIDQHESFPAWTTWADDHPLKAFFRDKAAIEEMVREAGFANWVILRPPVFMTNYLSPTVEGYFPELVSGVFRTALGPGKRTMLISPDDIGQIAAAAIAEPRRFSGRAIDIGAEALTAEEVAGALAEVGGREIRVEYIPDDEARELAKTNMLIDVQRWYWERQAGFDPKQVAEEFGLRFTSFRDFLRANEALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU94</accession>
    <name>A0A2I2FU94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane Pth11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_368466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699517.1">
        <property type="nucleotide sequence ID" value="XM_024844862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU94"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU94"/>
    <dbReference type="GeneID" id="36552562"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368466"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="350" mass="39122" checksum="535F22042AD4EC53" modified="2018-02-28" version="1">MVSPHDVPNKGPVFVQVTGVLTALAGVLVAYRLLWKAYMKTRLAADDAIITVSMVFQVVNTVMGDLACHYAFGRHRADVLRTGGNKILALKFFWLFQIFYKLVLGLNKLSFLSFYLRIFPTRTFRLVCWVTIGFVISTTFSFVIATIFQCIPVRASWYKDIPKTCVQNASFRWSWAGINTGLDIWVCLLPLPVLAQLQLDRTRKIGVMLVFCMGLFVCITSIIRMWAMVASTKTHDPTWGSFDALIWSAIEASTGIICACLPMLKHPIQKLLPGWFSSLSNGSRKSRSRSRANYQMSRLGSQSGVRTGARGEEDDDIDADAESMGSQGPLAKNQILMKTDIKMHSEPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV43</accession>
    <name>A0A2I2FV43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV-endonuclease UvdE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_367413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699794.1">
        <property type="nucleotide sequence ID" value="XM_024844806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV43"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV43"/>
    <dbReference type="GeneID" id="36552506"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367413"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000012">
        <property type="entry name" value="Related to UV-endonuclease UVE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="593" mass="66532" checksum="0BEDF02262EAF535" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV64</accession>
    <name>A0A2I2FV64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_392818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699816.1">
        <property type="nucleotide sequence ID" value="XM_024845995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV64"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV64"/>
    <dbReference type="GeneID" id="36553694"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392818"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000678">
        <property type="entry name" value="Putative UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000592">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000629">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000006">
        <property type="entry name" value="UV-damaged DNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="12"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="424"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="782"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1139" mass="125153" checksum="219C2F2EF820D8C6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV67</accession>
    <name>A0A2I2FV67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_392794</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699799.1">
        <property type="nucleotide sequence ID" value="XM_024845993.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FV67"/>
    <dbReference type="GeneID" id="36553692"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392794"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="2"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="960"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2332"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3504"/>
            <end position="3580"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="960"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2410"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2477"/>
            <end position="2486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB44497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="3581" mass="393175" checksum="B8BFD2664D39976D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVC4</accession>
    <name>A0A2I2FVC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tyrosinase</fullName>
            <ecNumber evidence="2">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_513725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699863.1">
        <property type="nucleotide sequence ID" value="XM_024855142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVC4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVC4"/>
    <dbReference type="GeneID" id="36562848"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513725"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="8">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="9">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="535" mass="59788" checksum="2BA338BC34998C97" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVW4</accession>
    <name>A0A2I2FVW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_479295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700049.1">
        <property type="nucleotide sequence ID" value="XM_024853656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVW4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVW4"/>
    <dbReference type="GeneID" id="36561354"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479295"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF222">
        <property type="entry name" value="ADAM FAMILY OF METALLOPROTEASE ADM-A (AFU_ORTHOLOGUE AFUA_6G14420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014144845" evidence="3">
        <location>
            <begin position="23"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="5">
        <location>
            <begin position="218"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="4">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="563" mass="60453" checksum="572E7E15F2123B87" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWU0</accession>
    <name>A0A2I2FWU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_479554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700328.1">
        <property type="nucleotide sequence ID" value="XM_024853695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWU0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWU0"/>
    <dbReference type="GeneID" id="36561393"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479554"/>
    <dbReference type="OrthoDB" id="4392204at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014118492" evidence="1">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="234" mass="25665" checksum="298D6577311BBEBF" modified="2018-02-28" version="1">MQLFLSLLGLGSLANIAHAGLGALNFPGGLPFLFNGAALINHPNWTSQHPRDSTLEGANFFSYVTDKGYLSFGWWLKPSSDTDYSHCKPDSSDFMWYEWSDKMYGCDDEGCKAHVVNYLVANNSEPSFETDYVFGVANLAAPELGSLSKSYFDEKQGASAVATRHVLSTAATTASDCCKALKTLRGVQNKYKIKLDFELVDICPQQKTVDSWHQGQIPLGGGCDLDGEFGHELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYY3</accession>
    <name>A0A2I2FYY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_467047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701146.1">
        <property type="nucleotide sequence ID" value="XM_024852452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYY3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYY3"/>
    <dbReference type="GeneID" id="36560150"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467047"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="249" mass="27771" checksum="423F09DECCBBA710" modified="2018-02-28" version="1">MPPPQPIPPCEFTNPCTTHLEPSSSSSTSTSTPSPSPSPNTTPPHPRKLISHIFGRNKTSTRLVPTHIWPHYCRKHYQRARYRAPNWPVAQVELVRLALDRMEVWGGVRGFQVVLRKRALVHSGSTSSTSAFGGGDGDGDGEGDDGEGEKEKGKGKGKKLSTKRKSKSKGKGKRPQKKRKAPAIHHAPVPDWLRHHLGEGRTFAEVRSMLDQLKGHLQEARRGKELRFPDIEILPALEEWVYAIPTEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ53</accession>
    <name>A0A2I2FZ53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_439613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701216.1">
        <property type="nucleotide sequence ID" value="XM_024849880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ53"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ53"/>
    <dbReference type="GeneID" id="36557579"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439613"/>
    <dbReference type="OrthoDB" id="5410752at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="463"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="582" mass="68948" checksum="2F62199E34DEF4CA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZL2</accession>
    <name>A0A2I2FZL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_500918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701371.1">
        <property type="nucleotide sequence ID" value="XM_024854154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZL2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZL2"/>
    <dbReference type="GeneID" id="36561860"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_500918"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="68"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="469" mass="54853" checksum="F3A359DFED597ACE" modified="2018-02-28" version="1">MSTGILKVTGNKVVDNNGTEVLLRGAAIGGWTNMENFITGYPGHESQHRAAMRRVLGDQKYEFFFDKWLEYFFTDADAKFYAALGLNCLRIPFNYRHFEDDMNPRVLKESGFKHLDRVVELCAQHKIYTILDMHTAPGGQNGDWHSDNPTSYAAFWDYKDHQDRTVWLWEQIARRYRSNPWVAGYNPLNEPCDPQHVRLPAFYERVEKAIRAIDPEHILWLDGNTFAMEWRGFDRVLPNCVYAMHDYSSMGFPTGQRYKGTPEQKEQVERQYLRKAEFMNRNGTAVWNGEFGPVYASYSDIDAEAINQERYNLLGEQLRIYDKYNIHWSIWLYKDIGLQGMIHTSPSSKWNQTIQPFLEKKNRLWLDNWGRRPSAEPEAALKPLVQWIDQVSPSAKETYPTSWNTERHMLRAVFQTFLAASFVDEFAELFRGMDEAELEALAHSFHFDECVQREGLNEILREHARVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZV4</accession>
    <name>A0A2I2FZV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Galacturan 1,4-alpha-galacturonidase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_449685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701467.1">
        <property type="nucleotide sequence ID" value="XM_024851061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZV4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZV4"/>
    <dbReference type="GeneID" id="36558760"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449685"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014164256" evidence="10">
        <location>
            <begin position="19"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="425" mass="45844" checksum="467659ABB2D00DEF" modified="2018-02-28" version="1">MHLSRLLFFLAALICVSAIRTSPRNTCVIPASGSNTTDDAPAIVQAFKQCGRGGKIIFKPTTYHVNSVMNITWLEDVDIDIKGELLWGTNIQYWLNHSLPVGYQNQSTAFILGGNNVRIDGHGVGTLNGNGDTWYQWIQKQPNTSNYPGRPHGITFNGLTNSVVRGLSFLRSQMWTMSIIYSHHVLLDNILVNNTGNVVSSSNTDGADTIRSSHIKFNNWTVYNGDDSISLKGNSTDITITNSHFYNGLGIALGSIGQYKDQFETIERLNVKNVKFDNTLHAVYFKTWTAEQNGYPPNGGGGGLGYASDMVLKDLTATSLRGSAVAISQCTRFIGAPGQGNCTSSEFQIRDITVANLSGTTKSSRVASLQCSAVAPCTDIGLLDVDLKLTNGTAARQYLCGNVKDPKGFNCTGPVCEGGSSTGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G008</accession>
    <name>A0A2I2G008_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_479128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701513.1">
        <property type="nucleotide sequence ID" value="XM_024853632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G008"/>
    <dbReference type="STRING" id="1392250.A0A2I2G008"/>
    <dbReference type="GeneID" id="36561330"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479128"/>
    <dbReference type="OrthoDB" id="5377172at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014114227" description="Arylsulfotransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56240" checksum="5BD259E6E0EC9C0B" modified="2018-02-28" version="1">MQAALHIASLLLFWATTVASASDAEEAWPAQIYKSSSARPPVMNMTKSGQTSSGYLFLTPENSTTHAESSFIFDDHTLIWEGPPGNITNFFPQTLHGQQVLSYWNGATGEGGWGFGSIHLLNASYDEIYKITLAGNETWVSPLLAEFPSYIGKHEAFITEKGTILVTAINATRRDLRPFGGPADGWIQDSLFYEIDVKTNEILFRWSGAEHTDMIDPRDSSRLLAGNRDGRTQGTPWDYMHINSIFPLGDDYLVSFKCMNTIFLVQSDGSVRWRLNGLTGGDFTLGPRTNFISQHNVRVYEHRFIGDHEILSISMHNNGVTCNKTSIFPSNGLLLDVDVTSMQVTLNRRLYNPNDPVYSTARGNCQMLPDNHVLVGHGIVAKLEEYDEKGNLVLDARFGFSPTDGNYAAMRSAWVGTPRTSPQAVACRWSLDRTRLYVSWNGATDIEEWEVWTGDVEDGLQYRTHVKKTGFETAAIIDGTPLYVAVRAVGGTNHGKSSTAVEVNEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G040</accession>
    <name>A0A2I2G040_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_458331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701536.1">
        <property type="nucleotide sequence ID" value="XM_024851787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G040"/>
    <dbReference type="STRING" id="1392250.A0A2I2G040"/>
    <dbReference type="GeneID" id="36559486"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458331"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000014">
        <property type="entry name" value="Probable acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000027">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF19">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FADE4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="49"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="166"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="280"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="443" mass="48537" checksum="EC0043F7E2486D20" modified="2018-02-28" version="1">MANCPGKRSLCHRLRPVLSKPSRVASRVAPRSGFSTTVQRPLMELAGFSEEQLMVRDAISAICAKFPNTYWQECDQQERDPKELHAALAKDGWLGIALPEEHGGAGLGISEATMMMQTITQSGAGMAGAQSIHANVYATQPLAKFGTKEQLEETIPKIINGTWRTCFGVTEPNTGLETLKLKTLALKHADRDGYSVTGQKIWITCAQVASKMILLARTTPLEEVQKSNQGLSMFCIDIDRSNPGLDMRKIKKMGGRAVDANEVFFDNYDIPSTSLIGQENDGFKIILHGMNAERCLLAGEALGLGYAALERAAHYASERVVFGRPIGQNQGIAHPLADAYMQLEAAKLATYHAARLYDASKTDESIPFHSVGVACNSAKYLAAEAAFKACERAVLSHGGMGYAMEYDVERYLRECLVPRIAPVSREMILNYVSEKVLQLPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G098</accession>
    <name>A0A2I2G098_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="11">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_439883</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701558.1">
        <property type="nucleotide sequence ID" value="XM_024849937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G098"/>
    <dbReference type="GeneID" id="36557636"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439883"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="12">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB46256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="688" mass="77995" checksum="12207EF513A2683C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0E4</accession>
    <name>A0A2I2G0E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline D-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_511149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701660.1">
        <property type="nucleotide sequence ID" value="XM_024854856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0E4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0E4"/>
    <dbReference type="GeneID" id="36562562"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511149"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014167034" evidence="1">
        <location>
            <begin position="24"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="110"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="429"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="573" mass="61020" checksum="B115549ADD8C73C6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1C7</accession>
    <name>A0A2I2G1C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_511376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701982.1">
        <property type="nucleotide sequence ID" value="XM_024854886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1C7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1C7"/>
    <dbReference type="GeneID" id="36562592"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511376"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="248"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="455" mass="51094" checksum="7D0C656EF0265999" modified="2018-02-28" version="1">MSSIFEDFISGQRIGSGPRLAAALSPVASAANPSRLLSFYYFSNAAHVSSDLRYSLFQSSGVKLPRQEQNAWIDIFTAYWKAAGELVKFEENPSQGSWVQVFEAWREVSNTLVRGYSHSGLQAWTVPCLYVVGKYLRLFAIRADAESSSQNSVSFGDRLQEDIAADFTKSAKLESAAWMMNRMFTLCLSDRAPLEESRKWGVYNMTNLLFKTYFKINSVGLTKNLLRALGAASADLPGLDAFPKAHVVTFKYYVGVINFLDEKYEEAESHLAEAWRMCYRDSPRNKELILTYLVPCHLVTTHTLPSQRLLSSFPRLEKLFRPLCECIRKGDLQGFDTAMSAGEEEFVKRRIYLPLERGRDIALRNLFRKVFIAGGFEEGKDGQPPIRRTRVPVAEFAAAIRIGTHASDRTRVDIDEVECLLSNLIYKGLMKGYIARERGMVVLSKGGAAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1G9</accession>
    <name>A0A2I2G1G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_362563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702024.1">
        <property type="nucleotide sequence ID" value="XM_024844529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1G9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1G9"/>
    <dbReference type="GeneID" id="36552229"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362563"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="79"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="569" mass="60007" checksum="1FE0639809669DB3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2F9</accession>
    <name>A0A2I2G2F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_511707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702357.1">
        <property type="nucleotide sequence ID" value="XM_024854918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2F9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2F9"/>
    <dbReference type="GeneID" id="36562624"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511707"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="527" mass="60081" checksum="8D717CF19268C844" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2H5</accession>
    <name>A0A2I2G2H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_448745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702368.1">
        <property type="nucleotide sequence ID" value="XM_024850990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2H5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2H5"/>
    <dbReference type="GeneID" id="36558689"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448745"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="547" mass="62083" checksum="A0B7F73337C7BEA7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G361</accession>
    <name>A0A2I2G361_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_439003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702616.1">
        <property type="nucleotide sequence ID" value="XM_024849738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G361"/>
    <dbReference type="STRING" id="1392250.A0A2I2G361"/>
    <dbReference type="GeneID" id="36557437"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439003"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="9">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="427" mass="46598" checksum="65003B6275717E94" modified="2018-02-28" version="1">MDTLPKRSGPALNGVARRSLGIGLLLIVVFLWTASNFLASTIFADDTYSKLFFVTYINTSLFILPLFTILLRRVWNLWRSGKTSRINSFRSLLRHLDSHDPDAETQSILHHDTGRDSEDALSDPEAWNAARLVPEGKYQEDSKLGLRATAKLSFEFCMLWFLANYFAMACLQYTTVGSTTILTSTSGVWTLIFGAVIGVEKFTVRKLLGVVASLIGIMLISRVDLSSSPDIPPADDSSSGGGGSTFPNKTPAEIALGDAMAGFSAVMYGVYTIVLKKQVGDESRVNMQLFFGLVGLFNMFLLWPGFIILHVTGIETFAMPDTSRVWTIIWTNSFASLASDICWAYAMLLTTPLVVTVGLSLTIPLSLVGQIILQGHYASGLYWVGAAIVFLSFLIVNHESQEGVAQEEERPSGAGYDAIPSEDGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G381</accession>
    <name>A0A2I2G381_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA (cytosine-5)-methyltransferase 1 replication foci domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702636.1">
        <property type="nucleotide sequence ID" value="XM_024849744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G381"/>
    <dbReference type="STRING" id="1392250.A0A2I2G381"/>
    <dbReference type="GeneID" id="36557443"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439025"/>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="67699" checksum="A178C894C311A3D0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3T9</accession>
    <name>A0A2I2G3T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_456394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702839.1">
        <property type="nucleotide sequence ID" value="XM_024851616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3T9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3T9"/>
    <dbReference type="GeneID" id="36559315"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456394"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000041">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="212" mass="22527" checksum="314BA150B769BF99" modified="2018-02-28" version="1">MSVTLHTTHGDVKVELFCEAVPKTTENFIALCACGAYNDTPFHRLMPGFMIQGGDISLGPAGSDTSSATKSMLPFDDIPKGGTSINHPGALNQEIHLPALRHNTRGILSMASRPVKDRTAPGSQGATGATINGSQFFITFAGAPHLDGASTVFGKVLNLTAQDEGGDVLSRLEKANVKVDKKGRVVQPKDGETEYESLRINRVTIHANPFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G445</accession>
    <name>A0A2I2G445_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nitrosoguanidine resistance protein SNG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_465267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702956.1">
        <property type="nucleotide sequence ID" value="XM_024852308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G445"/>
    <dbReference type="STRING" id="1392250.A0A2I2G445"/>
    <dbReference type="GeneID" id="36560006"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465267"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="90"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="389" mass="43345" checksum="F5E39068F7268DE3" modified="2018-02-28" version="1">MMLPGRFWVGIAGAFIALQLLFLANMCYIYGTAFHDSQRYSAMHVLYVDYDQGAIGQSVLAAYNTMQSPAVVTLEQHPVSEYPTEREIEQALTAAVQSPEAAQAYDRSQALQYYWKGTKYSAYATGVYSQLTELVQITAAVYAQTHGAGLLAAASSSNLTDPAIAATLLLPVGGTAVDVAPTDQGVRFYYNNVSMVMPIIQQFFFIMALNSLSAQFALGDRLSTRQHLLLRIALSLVYSFVGALVMTGYIWAFRESWALTGGQFALSWMAIWLVMHLHFLFIDFVAAFLPAGFLPFFVLTWIILNVSSSIIPFELSPGFYRIGYAFPAYELYEVLLQIWTDGCNPYLYRALPILWSEWLVALGLFFVGMRHRGKTVTRASVLDDKSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4C6</accession>
    <name>A0A2I2G4C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cholesterol transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_385597</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703021.1">
        <property type="nucleotide sequence ID" value="XM_024845735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4C6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4C6"/>
    <dbReference type="GeneID" id="36553434"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385597"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014119853" evidence="16">
        <location>
            <begin position="23"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1098"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1127"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1170"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1211"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="593"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB47719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1271" mass="139757" checksum="4A986B55A7DAA08F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4H3</accession>
    <name>A0A2I2G4H3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_410076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703078.1">
        <property type="nucleotide sequence ID" value="XM_024846830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4H3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4H3"/>
    <dbReference type="GeneID" id="36554529"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410076"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="311" mass="35434" checksum="5F7C289F9D295813" modified="2018-02-28" version="1">MLSSQHTGLSGRTYTIDQVLQEEPSPLRQVYRASANGQSFILKYIHPINFEDLQEVNNRLRGNANHVRLSVDTIPHKSMFVFEHFTDHLSTLAQKDLPLAVTKRILKKALTGLAELHARDIVHTDIKADNILVNWQTCNYEITVDQVQLGDLEDAAHIPPGCDMVGKQAGNWMWRSPEAHARGPVNKPSDIFSFALVCICAVDKRILFAVREDELEESVDPLAVVIERQMSYFADEDDLNGLLKHLGDNPWVRVFEVTRDGFNQENPREPFAFWNGVDDDFKDLVCAMTRFEPGKRITARQALEHKWFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G695</accession>
    <name>A0A2I2G695_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha methylacyl-CoA racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_386852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703703.1">
        <property type="nucleotide sequence ID" value="XM_024845782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G695"/>
    <dbReference type="STRING" id="1392250.A0A2I2G695"/>
    <dbReference type="GeneID" id="36553481"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386852"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="577" mass="63051" checksum="2C2C7E98E59E5FF7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6C7</accession>
    <name>A0A2I2G6C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703732.1">
        <property type="nucleotide sequence ID" value="XM_024849502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6C7"/>
    <dbReference type="GeneID" id="36557201"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438064"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="68" mass="7351" checksum="B6F83B33A644957F" modified="2018-02-28" version="1">MNGCLSVFRVRGFFFCVSQNVNAVVLPVLLGFILLRWLGVGDAEVRGFNSGCISRQTALVLADLGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6J5</accession>
    <name>A0A2I2G6J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_511064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703797.1">
        <property type="nucleotide sequence ID" value="XM_024854849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6J5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6J5"/>
    <dbReference type="GeneID" id="36562555"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511064"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="2"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="410" mass="45248" checksum="9EDAD210E93BA1A5" modified="2018-02-28" version="1">MEQNFQAAVETGEIPGVVLLATDASERFHYGNAIGNSSLKPGSERLFKLDATLSIASCSKIITTIAALQCIERGQFGLDDDVSTILVELQDLKIITGFDESTGNATFVPAENKITLRHLLTHTSGIAYDFINPVINRWRTSVGRTPDITSTEPILKRIALPLVFEPGEGFEYGYSMDWAGTLVSRLNNISLDEYVQKYIAQPLGIDDMTFHLENNDQVRSKLADFNLRDGGMNEYGTTANPNGAISWMPGHLWVDPVVDEYGGWGIYTSGPSFLKVLASILRDDGKLLRSETIDHMFQNQLSSASKDMLKRTLSVPEINNYLGGSPLGLEKGWGLGGLLMLEDSASTGQNAGTMQWAGLPNLFWWIDRKAALCGLYASQLVPTGDPRSVEWSTTFMKEMYIRLEESRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6T5</accession>
    <name>A0A2I2G6T5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_493903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703885.1">
        <property type="nucleotide sequence ID" value="XM_024854059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6T5"/>
    <dbReference type="GeneID" id="36561764"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_493903"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="593" mass="67070" checksum="B0DADF33741B8591" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6W4</accession>
    <name>A0A2I2G6W4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_166178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703916.1">
        <property type="nucleotide sequence ID" value="XM_024842598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6W4"/>
    <dbReference type="GeneID" id="36550296"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_166178"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="207" mass="22364" checksum="7FB0E786ECFE8B83" modified="2018-02-28" version="1">MAMSQSATLLPPPIPSWARSLTTQVPCNLPNGEQADPGCSVNSCTPDNWWTRIATAIGLFALPNNITPGATSLGSPGFATLARPVSSTGVPMPYVLDDNLTRWIATVAKPNGCENGGYPWCAYVSDWRRCVSVTLLRGRHRVMKLLGVIFSLNAIAITMLGPRDAPPMDPARYRSRTEEGVYKGGQRSRNSLPLSTSSSLLKLLQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6X6</accession>
    <name>A0A2I2G6X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pectate lyase</fullName>
            <ecNumber evidence="11">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_358842</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703917.1">
        <property type="nucleotide sequence ID" value="XM_024844319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6X6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6X6"/>
    <dbReference type="GeneID" id="36552019"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358842"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025086791" description="Pectate lyase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="234" mass="24772" checksum="40C8B034F477D8B5" modified="2018-02-28" version="1">MLSKLPLLAAFMPTALACLGYEGGVPKATATHSNSAVIEVAAGQVFDGGWARYDRGSGACGGQNEGDWKDAVFYLQSGATLKNVIIGKNQAEGVHCNGPCTLEFVWFEDVCEDAISVKNDKSGQETWIIGGGAYHASDKVVQHNGCGTVNIINFYVEDYGKLYRSCGNCSKQCKRNVYVEGVTARDGGELVGINSNYGDTATLKNVCYDTKNPCVTYEGCAGGCEPKKVGTCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7C2</accession>
    <name>A0A2I2G7C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_383065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704060.1">
        <property type="nucleotide sequence ID" value="XM_024845629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7C2"/>
    <dbReference type="GeneID" id="36553328"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383065"/>
    <dbReference type="OrthoDB" id="4514212at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="490" mass="54682" checksum="24E647DEC9B7FD21" modified="2018-02-28" version="1" fragment="single">MALVPQSTKTALQKQLEVLAELLSPIDKNLSNTLKDLGRRFEGDARATIQYLNKALKDVPRTEDKPTQNSSTVATPNDAVRKYFEQCNGLEEDEISQLIGLLKTFERKEDKVKKLTLAYEKYRENPTEFWTSFSNLHAGNSIKQTVSAIDHHSSSSPLARRLLCRRLAAEINSKAQELETQGHTLKRGMSYRDLAFQLSVGGDWKKHSSKLREGERWLCLDPGVLVAIKEPNWRSWARMRTIGIRAINNYLKNDPLTSTYQGISTPIQAIQDCFGSTVQNCITPTPSLTLSDSQGSSHLVPPVSLNHCEARTKRRRICQASDGDSRDGHQMRGCQPRIEDEPPGDREEGTESVEMHLLGLVEGTTGNIPSQQGGPLDFSCGIEGAPQVSHPTHRIVDNSLLPQTVEQTAIHERDTAQSFLTPEADQGSVRSGRAIPSLNSQDLSGGDLTSRHPFPNSDPCWNFPNFDSGWTQYTWLSPFSNSDPNFFYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7H8</accession>
    <name>A0A2I2G7H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_329615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704139.1">
        <property type="nucleotide sequence ID" value="XM_024843360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7H8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7H8"/>
    <dbReference type="GeneID" id="36551060"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_329615"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="69" mass="7722" checksum="828790BD8560B0E6" modified="2018-02-28" version="1" fragment="single">MLQSPTFTFLVGRNRTAFTIHSELVRDISPPLHVLMNNGNMKESREGVAVLEDVEADVFAAFCEYVYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7P2</accession>
    <name>A0A2I2G7P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_358722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704204.1">
        <property type="nucleotide sequence ID" value="XM_024844312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7P2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7P2"/>
    <dbReference type="GeneID" id="36552012"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358722"/>
    <dbReference type="OrthoDB" id="5373550at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000006">
        <property type="entry name" value="Positive regulator of purine utilization"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="816"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="816"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="937"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118832" checksum="10BF070617F247E9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G820</accession>
    <name>A0A2I2G820_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_475324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704295.1">
        <property type="nucleotide sequence ID" value="XM_024853245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G820"/>
    <dbReference type="STRING" id="1392250.A0A2I2G820"/>
    <dbReference type="GeneID" id="36560943"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475324"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000054">
        <property type="entry name" value="C6 transcription factor GliZ-like, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR RGLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="409" mass="44683" checksum="647FB57DD6B8A014" modified="2018-02-28" version="1">MTTAVPYLASPTEPPQDNPNHKQKLRSACDSCHQCKVKCSGGSPCFRCASKGFSCRYGYQNRAGKPKGSKNRKTLERAHQMRMQWLTEQLRGGNVELDEMTLNATDPSAFLPSPALSVNRWKSAHTPRSSSGSAPLDSTHKSAAGDITDEALPSPHNLDPWTTDLGSFLDTTPGSRSTSMESFTTPMSFTNGVGYFGPPNDPATPLTFDLPSPLPDLGRSGTICACVQSQATNVTTLHQLTSHQSFERFDLAMKSVTATLDTCDNFIACLECEKSFSAILLTLSALEMIFKLFEQLIIGHQYLLPQEEHRMISCSLGDYKVSQEEGQAIQNVLLKMTLSKAKQTLDSLHTLVTGPMEFLDDTERYEAPGADKGSPQGLGGLSNVDRDYIVQCITRKKTALDVLMTTVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8A1</accession>
    <name>A0A2I2G8A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_174835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704396.1">
        <property type="nucleotide sequence ID" value="XM_024842629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8A1"/>
    <dbReference type="GeneID" id="36550327"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_174835"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="166" mass="19579" checksum="0315640F3093E212" modified="2018-02-28" version="1">MLSQSPSLPRANCFYCRFCHLSAIRLHGNFSPQQWETETHTLRTYIQCFQPERGGLVSARRDSTAELFERRHRDSLQPREGPSKGTATAFLENMSEAKFDRANKDKALQKWRSSPLVKCIRLYWYLKTVHRRQQRSGNHPKHPLRYPPRHSWSLLESFTTQVERGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Z3</accession>
    <name>A0A2I2G9Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_465051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705003.1">
        <property type="nucleotide sequence ID" value="XM_024852292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Z3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Z3"/>
    <dbReference type="GeneID" id="36559990"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465051"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="280" mass="32095" checksum="54769EAEB27AE25B" modified="2018-02-28" version="1">MGSSSPCTACSWTSERQENCRYESHVKLFYEAGNRGVWSLGSNMILKDRGPGAPTREVENARFVEENTSIPVPTVVQSWNEDATGRTFILLKRVPGEPLSAAWPKLSADQKDNIARQTAQYLQQLRSLQSNCLQALNGGPIYSNFLFPNRTSDVPHGPLASDEDLWLDMERSLQHIPEASRVRLRSRMPPATPYTFTHNDLINVNIMVDNGRLTGIIDWEWSGYFPVWCGEDREWKALLRKHMPDYSAAREFWRDYWYLCIDPSSEKALKFLKEAESEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAN7</accession>
    <name>A0A2I2GAN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_435229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705246.1">
        <property type="nucleotide sequence ID" value="XM_024848894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAN7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAN7"/>
    <dbReference type="GeneID" id="36556593"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435229"/>
    <dbReference type="OrthoDB" id="2344312at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="123" mass="14270" checksum="FAC235AA3199AE8E" modified="2018-02-28" version="1">MSQIFTIWIVPFHVAPVTLTTVLDLTTESGDRGVTNGERTLYYVKQQEDLYQTTHFVKFLLPHIGAWMVSFFQFFATLFCICGAWLLWPLIWLEENGYVPNYLLTGGNIAYDIQQKVDEIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAZ2</accession>
    <name>A0A2I2GAZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_404770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705356.1">
        <property type="nucleotide sequence ID" value="XM_024846545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAZ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAZ2"/>
    <dbReference type="GeneID" id="36554244"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404770"/>
    <dbReference type="OrthoDB" id="5399817at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13016" checksum="52C476A9AC855AB9" modified="2018-02-28" version="1">MSTRLQATATGWLIISLGHTLSAKTWQSAPQFRALPNLPYSCAKVGWYQGSAFFLMTALLNYSWAQDPTLLELPVNRAIAALMTGIVWASSGWYFKRGVVENGVVVAVMGAVQAWAAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBU3</accession>
    <name>A0A2I2GBU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_354635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705653.1">
        <property type="nucleotide sequence ID" value="XM_024844044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBU3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBU3"/>
    <dbReference type="GeneID" id="36551744"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354635"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="71"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="434" mass="46164" checksum="0FCA81FE9C019927" modified="2018-02-28" version="1" fragment="single">FFSFSPTPSNTGNLFSSAFRRSFSYLRSSVGLTAAAASTLQHPSPPSASVLSSPLSTPLRVNSTSRMVHTKVVIIGSGPAAHTAAIYLSRAELQPVLYEGMLANGTAAGGQLTTTTDVENFPGFPDGVGGQELMENMRKQSIRFGTEVITETISKIDLSQRPFKMWTEWNDGPENEPARTADAVIIATGANARRLNLPGEETYWQNGISACAVCDGAVPIFRNKPLYVIGGGDSAAEEAMFLAKYGSSVTVLVRKDKLRASKAMANRLLAHPKVTVRFNSVATEVLGENKPMGLMTHLRVKDTVSGQEEVVDANGLFYAVGHDPANALVKGQVDLDEDGYIITKAGTSYTSLDGVFACGDVQDKRYRQAITSAGSGCIAALEAEKFIAEGESHEEAPVASTEKAAVKPATQEVDGEVKTDSQGTSAEYKSNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBW5</accession>
    <name>A0A2I2GBW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_142353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705657.1">
        <property type="nucleotide sequence ID" value="XM_024842477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBW5"/>
    <dbReference type="GeneID" id="36550174"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_142353"/>
    <dbReference type="OrthoDB" id="4227359at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="99" mass="10768" checksum="04B60B647081107A" modified="2018-02-28" version="1">MASTSTTTTTTSHKHDLLVSANFATTTSIPSKPTIDYDHEIYLQLTAEAGRPAKTANQVYLEERARQKSTRALDPAISDPQGEPGAIDFECAEKQGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCS9</accession>
    <name>A0A2I2GCS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nineteen complex-related protein 2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_355418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705983.1">
        <property type="nucleotide sequence ID" value="XM_024844090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCS9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCS9"/>
    <dbReference type="GeneID" id="36551790"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355418"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44364" checksum="ACE5F5C19BFE5191" modified="2018-02-28" version="1">MSTKFANRKKPRKIGGDDEDEGDEQDTGPVVKKPVSSKAKQKSKLRVSFGPGETSMADDEGQDSEVVIPKRPGLGRRALENTASKSTSGRNIPLRVGPEQDRPSYNNDYLKELRDSTPSTPKTPATDEEKEKTVDVAAKFGEVMKASAPAAIPSEAEIREKKARRARLAKEHGATVTEQDYISLEDNAGDAEWEEGAREDHRDTRLIRDDEDFAEGFDEFVEDGRISLGKKAEREQQRRQREQMKELINDAEGSSDEDDSDIEERAAYEATQTRAAMGKSGRDPFERPKTPPKMTSLPRLSTCLDRLRTNLAVMEQSKTQMIGRMEELRKEKADIAVREVEIQALIKEAGDNYEKLKQEAGRAPAAIEDGTADGDIQNSRGLESFGTPMAESSANSEIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDB4</accession>
    <name>A0A2I2GDB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_354240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706164.1">
        <property type="nucleotide sequence ID" value="XM_024844018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDB4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDB4"/>
    <dbReference type="GeneID" id="36551718"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354240"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="292" mass="31814" checksum="5C37F4A5A4D8B7A2" modified="2018-02-28" version="1">MATTKAIPAAVSDKTSDTAQQAAKTPLQLISQGACLPGIPRHPSFTAQRQWILEQMALAFRVFARKDYTDGMAGHISVRDPENPHTFWTNPLAVHFGILKASDMILVNYEGMPIGGNMSRPANAAGFLIHSAVHKARPDVEAACHTHSPHGMAWSAFGRPLEMLTQDAAYLYGDAQAVYQEFGGVVLTEEEGNRIGAALGPTGKGMILQNHGLLTVGSTVSEACFLMTLMERACQCQLLAEAAAANGLEKIYIPDESARYTFENSSEPETLYWEGQPDLQFEEYMSKGEHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDK2</accession>
    <name>A0A2I2GDK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_446152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706281.1">
        <property type="nucleotide sequence ID" value="XM_024850771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDK2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDK2"/>
    <dbReference type="GeneID" id="36558470"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446152"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="140"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="498" mass="54673" checksum="521E35625AD07030" modified="2018-02-28" version="1">MSEGRPALKLTFGKKKAPEEAAQPATPSTAAAPSTPAPAPSTAASDTPQRKLTLKIARKPAEGAEEEKPKKKKPSKKRPAEGPAVKEAQQQAGPKRLKLTASKKPGVQSIRIKHKSLKPTRPVGVGYDSEASDGETDPAIEEQFILRMPPGDDCDYLQKLIKEQGFNKSDFSFKPLTRDGRRAVIKVRDQQYAASLVDLPSIVEGMKSWDRRGWYKSADICQMLLVLGPIANDAEAMDYPLPSEIEHVEGKNLQYPHGLTPPLRWVRKRRFRERTSTRTIEQVEKEVEDLIALDDASASAVRYELIDSASLNRAEGLVQTGDYDDYDEYDDEQDAEGELEEAMEAAPPSFEDLEDTLVAEMEAALAAGADGETAVAAAAEAVAPGSDGGVYQAGTPMATKPSTPAAESSEDDSDVSDGEEADVPEDEMDEEQLERQRQMQQQREEITELETMIRTETAKWEKTQNHILRGKLAKRIQDLKRDLSLKKVSVGDGDDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE74</accession>
    <name>A0A2I2GE74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_406902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706497.1">
        <property type="nucleotide sequence ID" value="XM_024846654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE74"/>
    <dbReference type="GeneID" id="36554353"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406902"/>
    <dbReference type="OrthoDB" id="5411041at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="198" mass="22510" checksum="53BBAD74444017DD" modified="2018-02-28" version="1">MSTTTDPEASMQARREADYERFKTYAAMTFLVASPVLIALPPRKLDHLTVLLTSAFCVSANHLTRERTGRSIVERIESRISSTRSALPASGELPSERAREIQARLRAARDAQIKEGGLVSEELERLKARQRQEKGVLEQVWMGGEEEGWKERRLREEQQALEEGKGYGDLIKEHIWDVWTWGEKEGEEKGKDESGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE87</accession>
    <name>A0A2I2GE87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_446306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706474.1">
        <property type="nucleotide sequence ID" value="XM_024850782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE87"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE87"/>
    <dbReference type="GeneID" id="36558481"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446306"/>
    <dbReference type="OrthoDB" id="4466294at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="48"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="412" mass="45420" checksum="AF715BEC850197D6" modified="2018-02-28" version="1">MPAADNQYTDFRSVAVDGLPFFTPKQRVPVGTVILEDGETEESVTPAFRPITIRGKTFQNRIWVAPMCMYSCQDGMFSDFHIVHYGQWAMRGSALITIEAAAVTLRGRNTPQDAGLYSDAHIAPLKRVVDMIHSQSQKAAIQLQHAGRKCGVTPPWLGLRVVPDEFGGYAKDVQGPTAEPWNENYATPSEMTEEEIWEAINGYGEAARRAVAAGIDVIAVHGAHGYLLHSFASPATNKRTDGWGGSFEGRTRFGIEVARAVRRNIPKDVPLFWKISAVDWMPEGEGWCLADTLRYVPILAAEGVDLFDVSSGGTDRRQQVQLGQQYQVPFAKAVKELGIPNLFVGAVGWIRDGATVHDILSNNKADVVHVAREFLRDPNFVQKVALSTGTKVTWIDQYHRAPSKSSLEPLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEQ1</accession>
    <name>A0A2I2GEQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable pectate lyase C</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_425593</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706661.1">
        <property type="nucleotide sequence ID" value="XM_024847646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEQ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEQ1"/>
    <dbReference type="GeneID" id="36555345"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425593"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052063">
        <property type="entry name" value="Polysaccharide_Lyase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42970">
        <property type="entry name" value="PECTATE LYASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42970:SF1">
        <property type="entry name" value="PECTATE LYASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014158888" description="Probable pectate lyase C" evidence="18">
        <location>
            <begin position="16"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="355"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB51359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="415" mass="43754" checksum="BC1D062C350DB63A" modified="2018-02-28" version="1">MLLLGLFALLQPVCALIAFPGAEGFGANAVGGRKGEVYVVSNLNDSGEGSLRDAVSKTDRIVVFSVGGVIEIDDRIVVSKRVSILGQTAPGDGITVYGNGWSFSNADDAIVRYIRVRMGKGGDSGKDAITIAEGKRMIFDHLSVSWGRDETFSISGTGANITVQNSIIAQGLQTHSCGGLMQTDGGVSLFRNLYIDNKTRNPKVKGVNEFTNNVIYNWGGGGGYIAGSSSGESRVNIIGNYFISGPSTSVTAFTRGNENFHGYVKNNFYDPDQDGTLNGSELGESASSYGGMDLVSTKYDYPAVANTLTPEEAVAYITKSGGASKVRDDVDTQLIEQVKSYGKKGELISDEAIMGGAGELDGGSSPKDTDGDGIPDEAEEELGTDPNTADSMELHSSGYTNLEVWANSLVPSSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEW2</accession>
    <name>A0A2I2GEW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_400289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706721.1">
        <property type="nucleotide sequence ID" value="XM_024846316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEW2"/>
    <dbReference type="GeneID" id="36554015"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400289"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="548" mass="58892" checksum="5E5A0312B26274B4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF82</accession>
    <name>A0A2I2GF82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_376064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706841.1">
        <property type="nucleotide sequence ID" value="XM_024845347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF82"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF82"/>
    <dbReference type="GeneID" id="36553047"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376064"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="579" mass="63220" checksum="0413A982BF5ADCE3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFE7</accession>
    <name>A0A2I2GFE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_351010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706910.1">
        <property type="nucleotide sequence ID" value="XM_024843831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFE7"/>
    <dbReference type="GeneID" id="36551531"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351010"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="57" mass="6937" checksum="296C2A7F432532C6" modified="2018-02-28" version="1" fragment="single">KPRARYPDVELFNKKDKYNYKLFKLNIRTKLVSNSNYYPSGLEQVFYIYNKLRGQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFP2</accession>
    <name>A0A2I2GFP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_461866</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707010.1">
        <property type="nucleotide sequence ID" value="XM_024852070.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GFP2"/>
    <dbReference type="GeneID" id="36559768"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461866"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3500.10:FF:000005">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1189"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB51708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1420" mass="163070" checksum="3519496998D5CEAB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFY1</accession>
    <name>A0A2I2GFY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_87492</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707083.1">
        <property type="nucleotide sequence ID" value="XM_024855419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFY1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFY1"/>
    <dbReference type="GeneID" id="36563126"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_87492"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="187" mass="20925" checksum="44ADBF127E04DE2A" modified="2018-02-28" version="1">MAPTPRKMNFITGNKNKLAEVRAILGSVVEVDNQSVDVPEIQGTIEDIAKEKCRRAAEVVGGPVLTEDTALEFRALKGLPGPYIKHFLDALGHEGLNKLLDSFEDRTAEAVCTFAFCSGPDSEPILFQGRTEGTIVRPRGPSNFGWDPIFEYQTRTYAEMEKEEKNKISHRYKALIKLQQWLIEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG61</accession>
    <name>A0A2I2GG61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707174.1">
        <property type="nucleotide sequence ID" value="XM_024852871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG61"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG61"/>
    <dbReference type="GeneID" id="36560569"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471795"/>
    <dbReference type="OrthoDB" id="5385072at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="371" mass="39850" checksum="AAC4A88BBDF34C4F" modified="2018-02-28" version="1">MAGVQLQQPSMTDYRLHQPPPARKPVPGMRSGHSFQSYDGHHQLSPHPSAASLAHSRSRTSSSHVLPYVAHHQQQQPQQQPYSAGPSPHHTMTTPPNYIPSRRLSSATTSTSSTGNAVGSHPVASDIRRSTSSRSANAQLGYVALMRRQKATVWCDRAQPEDPRIRAQKLVDKKRAYLEVHGAGAGRSGTLASNKTKHGTKGTTEFSPSTLVGATVPVRLSANEVGDADDDSRSDNGFPYRRTGSGRSSLGSNRYPSGYQRTPQGTMGSNVTPPGEKSDLPGVSENPPAEHHEEEKDAASFKDDAATTHSRTSEQEDNFGSVGDMAAPSAVTAAAEKAKKADELRRRGSVDDRTTSMTNVRLFVANPDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGC2</accession>
    <name>A0A2I2GGC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IF4E-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_444041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707233.1">
        <property type="nucleotide sequence ID" value="XM_024850600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGC2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGC2"/>
    <dbReference type="GeneID" id="36558299"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444041"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="357" mass="39071" checksum="49A5CE535F23766E" modified="2018-02-28" version="1">MDNANLWTRRSNTSKLSLSMTGTDGKEGGARVEIPRTAKRFGPDSSHGRSNPFNALSPLSGGVSSPSTNASSAFGLGSGAFASFGAPKTPGGSSDLKTPGGEKRDFTSEPEFVEKTKSSAVLSSKDHLLKSTWVIWYRPPTPKYSDYEKSTIPLASISSVESFWSIYAHLKRPSLLPAVSDYHIFKKGIRPVWEDEANKKGGKWVVRLKKGVADRYWEDLLLAMIGDQFAEAGDEVCGAVLSVRSGEDVLAVWTRIDGGRNIKIRETIKRLLGFPIDTNIVWKSHDDSIAQRSAIDQARQEKAAGNAGHHHHHHHHNNNNNNNHNNHNNNQHHPGGDRRRHTGNEESTGDKGKGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGK8</accession>
    <name>A0A2I2GGK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_471926</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707315.1">
        <property type="nucleotide sequence ID" value="XM_024852885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGK8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGK8"/>
    <dbReference type="GeneID" id="36560583"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471926"/>
    <dbReference type="OrthoDB" id="4506394at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="252"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="575"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1208" mass="131534" checksum="F3E40CE7E42DA897" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGQ4</accession>
    <name>A0A2I2GGQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_506954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707367.1">
        <property type="nucleotide sequence ID" value="XM_024854432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGQ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGQ4"/>
    <dbReference type="GeneID" id="36562138"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506954"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08039">
        <property type="entry name" value="Adenylation_DNA_ligase_Fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="384"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="756"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="756"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117947" checksum="AB97715DF467E1BB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGV6</accession>
    <name>A0A2I2GGV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_349741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707412.1">
        <property type="nucleotide sequence ID" value="XM_024843758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGV6"/>
    <dbReference type="GeneID" id="36551458"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349741"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="288" mass="32820" checksum="5D2DC58DB0A85086" modified="2018-02-28" version="1">MDPNPISTKALTAWQNHAKAWDEHMGDDGNAYFSALELPILERMVVRRNGARAIDLATGNGLVARWLAREGASVIAMDGSRPMLECAEKRTESWYQQGRLKREQKIGFEVLDVVSREGWEKFISRVLEDGFDIITMNMGLMDISDLKPLASALKRLLKQDGCFVATILHPLFFTSGADRQITFHENPVTGQREVTRSIILNKYLDVPPARQLLFSEDEKIPPPFSFHRPLHELFAPFFQEGLVLDALEETNFDESFVDKQREHSSKNFLQFPKILGFRMRRAAVDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGY3</accession>
    <name>A0A2I2GGY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative isoflavone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_377665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707442.1">
        <property type="nucleotide sequence ID" value="XM_024845412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGY3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGY3"/>
    <dbReference type="GeneID" id="36553112"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_377665"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="296" mass="31778" checksum="CAE1306EA4EACF02" modified="2018-02-28" version="1">MAPTKVALAGGTGNLGTAILKALLDANFSVTVLSRTSNKPIDQRAKLVEVDYSSQSALESALTGHSAVVDALGRAPQDVPIRLIDAAVNAGVTHYLPSEYGVDTQNEHVRKIPVFAGKVAVQSHLEKVTSTNPSFIYTLLATGAFLDFGLEKNFILNFAGPVADLYDGGERKFSTTTLAGIGGAVVGILRNPDATRNRAVYVSEADVSQVELLRLSGKKVETRVVRTEDLEREAYEELKKPEPSPAVFAVNFIKTALFGERFGSLFGPPRLSNEIVGVKYLSEEELREVVVKSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH00</accession>
    <name>A0A2I2GH00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_401977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707409.1">
        <property type="nucleotide sequence ID" value="XM_024846398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH00"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH00"/>
    <dbReference type="GeneID" id="36554097"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401977"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="36681" checksum="47A3C1E167C04DEF" modified="2018-02-28" version="1">MSTNTEPVWDSSVIRLEHMPPQAKIWQSSDDWTGVIDRKQRRKLQNRQNQRAYRRRRKHDEPDLPSQIPSSAVMLVQSFDLPTPQPSPQSIQDPHPDAEYNNDQIQCHHAPRHALSMRRTFNAILQQAYMDRSPRLEHLIGLSRLNVHRAINENITALGMTPSWMISDAAISIFNVLQPGPWGHDHEHTIPDSLRPTEVQRTVPHHPWLDFFPFPNMRDRLILAQDVIDEDDLCHDLMAFWDTRNTQATLLVWGQPWEPRNWEVTEGFARKWGWLLLGSPEALVASDSWRRRRGERGLAWREILGVSTTTSTSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH41</accession>
    <name>A0A2I2GH41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1445-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_472106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707503.1">
        <property type="nucleotide sequence ID" value="XM_024852910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH41"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH41"/>
    <dbReference type="GeneID" id="36560608"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472106"/>
    <dbReference type="OrthoDB" id="10262538at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016938">
        <property type="entry name" value="UPF0317"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029755">
        <property type="entry name" value="UCP029755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30578" checksum="B75EF2D045F753C0" modified="2018-02-28" version="1">MSSSSSSSPSYEARLLSRTNLITNTSGIAPGYLQANLLILPSKHADDFHNLCLRNPVPCPLLGRTTTPGNPHLVEPPSCIQNADFDIRTDFPKYRVYQHGQYLSTRNDLLDIWRDDYVGFLIGCSFSFEDALTSAGLQPRHQKTGRIVAMYRSNIPLLPAGIFTGGSCIVSMRPYRPEDIETARNVTRPYLATHGEPVAWGWEAVEKLGIRDINSPDFGEPQVMEEGEVPVFWACGVTPQMAVECAGDKIDDLVFAHEPGHMLVTDLTADDLQSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH51</accession>
    <name>A0A2I2GH51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_444247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707508.1">
        <property type="nucleotide sequence ID" value="XM_024850615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH51"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH51"/>
    <dbReference type="GeneID" id="36558314"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444247"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="21"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="342" mass="36625" checksum="FF7BE0E8D02562AF" modified="2018-02-28" version="1">MPGLLQTFLLSAAAASSNYRIDVHSHVVPQIWKDAMIEAGYPVQNGSLYADGFPVPDWTLEDHIATMDSLGVNYSTISISAPGVFFIKDPSKAQALARSINLEMHTYTTQYPDRLGALCLLPLPHVQESLVELEHCLTTLHFPGAATFTNSAGTYLGNSTLDPIFASLRAHNAPVFIHPAAPGCSAVSMGYPVPMTEYPFDTVRAIENLLLTGQRARYPDVRMIFAHGDGALPYLASRIAGMSSMPFLGGLSVSESMGQLAGYFFDTASATSRVQLQALKEFVGVGGLVTGTDYPYVPTTQAQPAVKAIQSNGEFNASAMARINHGNALGIFPRVAEILGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHD4</accession>
    <name>A0A2I2GHD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative SAGA-like transcriptional regulatory complex subunit Spt3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_434090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707594.1">
        <property type="nucleotide sequence ID" value="XM_024848643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHD4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHD4"/>
    <dbReference type="GeneID" id="36556342"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434090"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="325" mass="36993" checksum="92A52711B03B5B59" modified="2018-02-28" version="1">MSSDRTPKYRQEIQQMMFVSGETAEPSVETTTLIEEIVRQQVVEILVRSTALATRRGVRSISTDDLIFLIRHDKAKVSRLKTFLSWKDVRKNVKDSDDKGGGADAADFAGADDPIAGGVVAGPQDVASKPKNKRARVGLAWDVNSFYSVQVPERDDEEDEEEEEQNYATLQRLAAADERTKHMTKEEYVFWSECRQASFTYRKSKRFREWAGFGIVTESKPNDDIVDILGFLTFEIVQTLTEEALKVKEREEREKNRRGGTENGESTKKRKRETGLFDPPEEGRTPVEPKHIREAYRKLQATPSKNIAMLLHNGSLPARMPLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHH3</accession>
    <name>A0A2I2GHH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_423216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707634.1">
        <property type="nucleotide sequence ID" value="XM_024847488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHH3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHH3"/>
    <dbReference type="GeneID" id="36555187"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423216"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="276" mass="30430" checksum="42760936071FE55F" modified="2018-02-28" version="1">MASNTVTAQQLADAKAKFKQDGWAVLPDVISPEKAKEVVDRLWKAKEESERRGDPTYLDWLDPNSSNVRIFYLMELDPVFRELISHPTAVEMVQSALGQNFLVSNFTANIALPGSKSMGLHSDLSLQCPDPWLSTWGLNVIWCLHDTYKENGATMYIPGSHHWTAKSQVPSDDEARKLLVPFEAKAGSIIVMDGRLWHTSGCNTTEDKERALLFGAYNAPFLRGQVNWGVGLSEETKKTLSPELREWLGVNRDGNLGVVTGVNDVFAEGSAAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHZ9</accession>
    <name>A0A2I2GHZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_402737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707802.1">
        <property type="nucleotide sequence ID" value="XM_024846440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHZ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHZ9"/>
    <dbReference type="GeneID" id="36554139"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402737"/>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="723" mass="81609" checksum="23A8EED2FB445D45" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI62</accession>
    <name>A0A2I2GI62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl coenzyme A transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_423412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707863.1">
        <property type="nucleotide sequence ID" value="XM_024847506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI62"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI62"/>
    <dbReference type="GeneID" id="36555205"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423412"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="89348" checksum="1C2AB1BF53B7DD1D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIG4</accession>
    <name>A0A2I2GIG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MRS7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_403079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707976.1">
        <property type="nucleotide sequence ID" value="XM_024846458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIG4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIG4"/>
    <dbReference type="GeneID" id="36554157"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403079"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="245"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB52674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="546" mass="60441" checksum="52B4A6388AF0AF11" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ84</accession>
    <name>A0A2I2GJ84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_462761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708244.1">
        <property type="nucleotide sequence ID" value="XM_024852117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ84"/>
    <dbReference type="GeneID" id="36559815"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462761"/>
    <dbReference type="OrthoDB" id="5394254at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="346" mass="36932" checksum="4ED729F9B65B8DC0" modified="2018-02-28" version="1">MAPRKKDVLSTVTDKTESAADAVDRSTSHLRQKTQLERVPSPVRFLLVVASSLILSSTLFTLSTGITQGELGDVSKHREGWWEVGGLTAWKAVEVGLAWILGFDGRDVSSFIFFTHLPTFALLASFYHIRPTTVLISYAVILSSTSIPFMVLRNPSSVHNLSGAPRGAVSNRSILQDRATTIYTTVAATSIFTVVLYISYATWIPAQLVLHFVNIPDISAVHAGPAGLPVLFVALLPAGWAARDFLFASSAGALASKSDSSSARQGEYLASAIYRKSWGSLSAKTRVLISRACILASMLVINTVVQLVGTVDGVDIQGASAWGSLWAVATFAVAGTFGWIEAVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJG7</accession>
    <name>A0A2I2GJG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_507746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708331.1">
        <property type="nucleotide sequence ID" value="XM_024854508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJG7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJG7"/>
    <dbReference type="GeneID" id="36562214"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507746"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="518" mass="53284" checksum="2CD67AE0912F5171" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJQ2</accession>
    <name>A0A2I2GJQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_434821</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708406.1">
        <property type="nucleotide sequence ID" value="XM_024848810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJQ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJQ2"/>
    <dbReference type="GeneID" id="36556509"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434821"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
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    </dbReference>
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        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="6"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB53104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="519" mass="56855" checksum="7D3775BA71CB7230" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK94</accession>
    <name>A0A2I2GK94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_454418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="PLB53308.1"/>
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    <dbReference type="STRING" id="1392250.A0A2I2GK94"/>
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    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454418"/>
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    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="70821" checksum="44E45963D5B664FF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK95</accession>
    <name>A0A2I2GK95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_424060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024847544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK95"/>
    <dbReference type="GeneID" id="36555243"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424060"/>
    <dbReference type="OrthoDB" id="3904217at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="164" mass="18041" checksum="C7E4FCC8F66C7B7A" modified="2018-02-28" version="1">MAMSQKPRHDILLGSWSLLECKTTDLNGKETNFPMGQSPRGLLMYTTDGYMSAQLLSQSPETRPSTEFSVTDFVAYSGRFEVVQLPKDGNCLRVNHLVAVASFPDWIGQVQSRIARFNDEEGLMELSTASPIFLAGRQCHATLQWRKSSTAGGTEASGDFTSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKJ4</accession>
    <name>A0A2I2GKJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">succinate-semialdehyde dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_463101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708702.1">
        <property type="nucleotide sequence ID" value="XM_024852138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKJ4"/>
    <dbReference type="GeneID" id="36559836"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463101"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="494" mass="53182" checksum="EB1C8496703E7AEF" modified="2018-02-28" version="1">MSTIPRNLKRKDLFQTKGFIAGSWVDAQDGATFEVRNPASLETLATVPEMGAADTAKAVAAAHEAFKSYKKTSARERARCLRQWNALCHEHVDDLALILTMENGKPFAEAKGEVLYAASFLEWFAGEAERTHGEVVPSANRNQRILTIKEPIGVAACLAPWNFPIAMITRKVGAALAAGCTTVWKPAGETPLSALAQVVLAKESGFPVGSINVVTTLNKVGEVGEALCTSKFVRKLSFTGSTRVGQLLARQCSTNLTKLSLELGGNSPFIVFDDAKVETAVEACLLAKFRNSGQTCVTANRIFVQRGIYQEFMQALIAKIKTLKVGDGMEKDVFIGPLTHERAVGKAMEHIKDATSRGASVELGGGPFRPGDLDGYFFQPTVLSGMSMESLTTQEETFAPVVALYPFDTEEEVLEKANDCDVGLGSFVMTESTPRMWRVAESLEVGMVGINLGMLSACESPFGGVKQSGYGREGGRGGIDEYLTVKSILINVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL13</accession>
    <name>A0A2I2GL13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fructosyl amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_400888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708857.1">
        <property type="nucleotide sequence ID" value="XM_024846352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL13"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL13"/>
    <dbReference type="GeneID" id="36554051"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400888"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF45">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="447" mass="48923" checksum="43B9481C2DE95181" modified="2018-02-28" version="1">MDKHQQIIIIGAGVFGLSTALRLIQEGYTSVTVLDRAVPPVPDGSSVDISRVIRFDYGDAVYARMGKEAFDLWKTPEYSEAFHQTPCMWLTQESSEDQIVQPAAHEYSVKTRQILTDMGEPWTHVPTPEAAKERFPMLTGKLAVPGFDAFVNEAAGWADAALAIARLAARCASAGVGFITGKNGQVEEFEKAADGTVTAVRTATGARVTGDRFIVATGAWTASLVPAWNSMVAAAQIVGYMRLTPEEMIQLKDMPIYFNFSTGFFCFPAHQPTGYLKVACHSYGYTNSSEQGISAPPKLPPSSRANFIPEDGVQRLTAGMRDMMPQFASRGFEKVGLCWYNDTPTGDFILDYHPEHKNLFIATGGSGHAFKFLPNIGKYAVGCFERKLSADLLDKFKFPLDFRGRQDAFKGDGSRGGPERRELLSHEQTSFGSALKNATPIAKQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL87</accession>
    <name>A0A2I2GL87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_371800</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708945.1">
        <property type="nucleotide sequence ID" value="XM_024845185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL87"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL87"/>
    <dbReference type="GeneID" id="36552885"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371800"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="17">
        <location>
            <begin position="182"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB53643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="481" mass="52994" checksum="E9089581B67EF8F1" modified="2018-02-28" version="1">MATATALPNGHATASSIAAEERRRLHHHGDVVIVGAGILGCALAVTLGRQGRSVILLEASMKEPDRIVGELLQPGGVQALEQLGLQDCLEGIDAVPAVGYYVSYLGEPVVIPYPKPSPSAPAPEGRCFHHGRFIMKLREAALACPNVTIVETKATDLVTDPHTKQVLGVECMTKEVRDCYFGHLTVVADGYASKFRKQYHDRSPKVRSRFWGLELIDTKLPVRHYGHVLLSDNAPPILLYQIGTHETRILVDIPENLPSASVKNGGVKNHLRSVTLPSLPESVQPAFLAALEKGQLRSMPNSYLPAAQNKTPGLVILGDALNMRHPLTGGGMTVAFSDVVVLRELLSPEKVPSFEDTDRVLRQLSSFHWQRKKGSSVINILAQALYSLFAADDEHLRALQRGCFRYFQIGRIEGPVSLLGGIIKKPVVLFNHFFTVAFLSLWMLIQEAPLYKLPMVIWQCVMVFWTACVVIFPYMLIEAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLS4</accession>
    <name>A0A2I2GLS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_431632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709133.1">
        <property type="nucleotide sequence ID" value="XM_024848079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLS4"/>
    <dbReference type="GeneID" id="36555778"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431632"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="84" mass="9556" checksum="7E89E23781119506" modified="2018-02-28" version="1">MAMSALLPFPGFLCFVFRTRIGQTSTIMRWLSYLSALRHQGSSPLNERRSATHPYPHQIVKRDLIVAGQGVLFVHTRTIIHLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM82</accession>
    <name>A0A2I2GM82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_343735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709286.1">
        <property type="nucleotide sequence ID" value="XM_024843419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM82"/>
    <dbReference type="GeneID" id="36551119"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343735"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="37101" checksum="DEBC16BAC3863111" modified="2018-02-28" version="1">MAPKIIYLENETLSFLLPRGSLILCSCTLAIVLLSNVLERWLLAKLYQIIWKDLSLGRNERRRRSFTYFHIGVTIMLILVLFGAYPVFDFLVGHARVSSTLHRNVTYGDYMFVLSHVYSAYYIFEVCFRTRFASAISIAHHIGLLIVIQTTLTLFGDLRKYPEAILEFYMCMVWGSFDVVVELPLYTFMIIWRVKANDHHLLSRMAYACCVWVLLGATVETAVTIWLLKSSWHRWGTSCRILLPLVFSLWICTQLYGAFRIFGMAQSKARLASTRSGITEDCDREIAEATGYRKSHSSEAHDQVTQFQESTNPERQRFPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMI5</accession>
    <name>A0A2I2GMI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_482410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709361.1">
        <property type="nucleotide sequence ID" value="XM_024853884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMI5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMI5"/>
    <dbReference type="GeneID" id="36561582"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_482410"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="528" mass="49750" checksum="3F2CAA4C0F24D0E3" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMW5</accession>
    <name>A0A2I2GMW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LPXTG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_504975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709491.1">
        <property type="nucleotide sequence ID" value="XM_024854256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMW5"/>
    <dbReference type="GeneID" id="36561962"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504975"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014178142" description="LPXTG-domain-containing protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="35735" checksum="55FDE387BC95F870" modified="2018-02-28" version="1">MIKSSSPRSTVLGFILGWTLFSNPVWSLAVTGSSSCTETCGDNGVTFSTDLVCTDSSFNETSKGLKLKNCLLCESTSTAYDSPTQNDVYWFLFNQKYILQDCLFDREPDVSLSPCESSCLPLRSVFKTLWYQDGWIPQYEYCEMGGGAVETYAGDCADCLRGKTGSMFLGNFMDTLDSGCRNKPNASDGETVKLRQALFATETKTSVPTTSASKSTGSPTATSTASTAPTASETSAPDAIAQPESSKTKSSLSTGAAAGIGVGAGAGGLIVIAAIVWVFFLRKRRRPSNEKYAPGWSDESTSSLKYSAPLAEMPAPEFANRRELEGTSRAELPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN04</accession>
    <name>A0A2I2GN04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_460459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709573.1">
        <property type="nucleotide sequence ID" value="XM_024851943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN04"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN04"/>
    <dbReference type="GeneID" id="36559641"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460459"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014122721" description="ASST-domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="69820" checksum="03CBD9B30D2C7222" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN08</accession>
    <name>A0A2I2GN08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_397430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709541.1">
        <property type="nucleotide sequence ID" value="XM_024846175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN08"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN08"/>
    <dbReference type="GeneID" id="36553874"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397430"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000094">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="194"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="628" mass="69245" checksum="3F0C8CE5F21777CE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN85</accession>
    <name>A0A2I2GN85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_452130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709653.1">
        <property type="nucleotide sequence ID" value="XM_024851248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN85"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN85"/>
    <dbReference type="GeneID" id="36558947"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452130"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="2">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="609" mass="66332" checksum="D26550C0C6C0298B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN88</accession>
    <name>A0A2I2GN88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_421056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709622.1">
        <property type="nucleotide sequence ID" value="XM_024847338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN88"/>
    <dbReference type="GeneID" id="36555037"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421056"/>
    <dbReference type="OrthoDB" id="3358048at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="230" mass="25523" checksum="015789201D817581" modified="2018-02-28" version="1">MGDDNHRRWFTGNYQTRQTSSAFSSGGPSRLNPIRSTTYSMATARLRRVFRYPDDSGGEEPGREDLDEEEQELVISRLKAQNDRQNIGYSAIFSAVPIFPAVMLVPLALSGSMRLPERLFSLLGLLSLLLTACIMKFSPLQRLATEGLVSRSRILAAVLRFSVPVNAITCGLLALAYMMGPRASPASGTQLLLIYFVPGVMFTSVMVVRHAMATVELRHLEDLRYEYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNU0</accession>
    <name>A0A2I2GNU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_469997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709838.1">
        <property type="nucleotide sequence ID" value="XM_024852694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNU0"/>
    <dbReference type="GeneID" id="36560392"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469997"/>
    <dbReference type="OrthoDB" id="4493482at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="249" mass="27049" checksum="E4A726D3E8D0546D" modified="2018-02-28" version="1">MDHEPTRSSSTDSTCSLKRSNAVYRRGSSLDNIPIPTVEAPEEYFTEELIMSPLSFSPSSSDSDSHYGFDEHSEETLPDELCPPGRMNWDAVIDLPEYIQAWAKIGMTACEIGQNLHRFVYGQDATLSNLVTTGVGSSTPYFEIGNAVMRNLDLRDAEGRLLHEQVPNGDETLRALPEKEKGLDQLAAFAAATSGDTVGGLGSGSPKFEVCAKPKRVRFVEPESPLRSRSASICGAFDDEASYDASGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNY4</accession>
    <name>A0A2I2GNY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_452317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709883.1">
        <property type="nucleotide sequence ID" value="XM_024851256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNY4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNY4"/>
    <dbReference type="GeneID" id="36558955"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452317"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="551"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116055" checksum="206E6E6C5605C804" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPK7</accession>
    <name>A0A2I2GPK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_398575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710108.1">
        <property type="nucleotide sequence ID" value="XM_024846229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPK7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPK7"/>
    <dbReference type="GeneID" id="36553928"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398575"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="517" mass="57204" checksum="1AE9AC484757761F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPU4</accession>
    <name>A0A2I2GPU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_460889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710198.1">
        <property type="nucleotide sequence ID" value="XM_024851984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPU4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPU4"/>
    <dbReference type="GeneID" id="36559682"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460889"/>
    <dbReference type="OrthoDB" id="5402033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014146157" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="83514" checksum="DB08269FAC8E848A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPZ6</accession>
    <name>A0A2I2GPZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_27245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710244.1">
        <property type="nucleotide sequence ID" value="XM_024843150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPZ6"/>
    <dbReference type="GeneID" id="36550849"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_27245"/>
    <dbReference type="OrthoDB" id="5274873at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="146" mass="16155" checksum="33E2C6C4C91A724C" modified="2018-02-28" version="1">MYYILYLASLCRRRRWPEPQYESYASTSGFTCTVRVNNREYQTDIVCENETLAREGAAMRAYLICRNFSVNDGMYPAGHDHGGVVQGIPVAIGTGRKPRYGDDTDISTSGESRSGGSSPESYEGGRIDRDRPVGPSRALAFESRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQB4</accession>
    <name>A0A2I2GQB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerol kinase</fullName>
            <ecNumber evidence="4">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_343477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710374.1">
        <property type="nucleotide sequence ID" value="XM_024843404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQB4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQB4"/>
    <dbReference type="GeneID" id="36551104"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343477"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="7 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="54"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="318"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB55072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="568" mass="62752" checksum="70F0EE3AC6A285A6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQP5</accession>
    <name>A0A2I2GQP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_505809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710502.1">
        <property type="nucleotide sequence ID" value="XM_024854324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQP5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQP5"/>
    <dbReference type="GeneID" id="36562030"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505809"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="238"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="608" mass="68482" checksum="B8A0F49DE3C506D6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS83</accession>
    <name>A0A2I2GS83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_461531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711032.1">
        <property type="nucleotide sequence ID" value="XM_024852044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS83"/>
    <dbReference type="GeneID" id="36559742"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461531"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="13457" checksum="8C34B673F7F1F1A9" modified="2018-02-28" version="1">MTPAPPYTETAHPPPPPPPTKSHRSGLISILLICILCTQIISAVLLGLCLSCLGSIDKFIAIRLPRLVTPTPTPSAMVVRFEEDQPPLPVEVYGIPLVHVNGVDDVVRVTTEVASVSEEEEIQGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSH4</accession>
    <name>A0A2I2GSH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_506337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711127.1">
        <property type="nucleotide sequence ID" value="XM_024854386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSH4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSH4"/>
    <dbReference type="GeneID" id="36562092"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506337"/>
    <dbReference type="OrthoDB" id="4358740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="14576" checksum="1271E4430F9940CE" modified="2018-02-28" version="1">MTSLSDIRNEILSDDIPKRLVIKHPDSRVLFLAIDVWSERAFLVIDINHHDYDFDTAHKDTAVFPVCVLRQRGRGRDWVLIRWPREDEPLAAMLADLHNVNGSDPIPFLEDHTSRLVHASPREFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQI2</accession>
    <name>A0A2I2FQI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_314685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000020">
        <property type="protein sequence ID" value="PLB42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQI2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FQI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_314685"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="125" mass="13630" checksum="CC4018ADB59EEDBD" modified="2018-02-28" version="1" fragment="single">GVICTNLAKDRADAQRLVATRLLDRVHDPLGFIPARGFLPGSRRQPAEVHGPEAYSYPTTTCGQHHPRSGTDSDLEAFSHYPADGSVAALPGQTAAKTNYLNQRFLSSRSLLVGEQSNAYRILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQN5</accession>
    <name>A0A2I2FQN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_78801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000018">
        <property type="protein sequence ID" value="PLB42935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_78801"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="64" mass="7317" checksum="4164A27EE08CF45B" modified="2018-02-28" version="1" fragment="single">MKFTTHLELHSQNNSTRRRSFTRRGHPVPDGFSPSMTARSRALRRGRTRSILCKLQLGPRGGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRD2</accession>
    <name>A0A2I2FRD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_418941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698468.1">
        <property type="nucleotide sequence ID" value="XM_024847253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRD2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRD2"/>
    <dbReference type="GeneID" id="36554952"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418941"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="800"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="815" mass="87354" checksum="4DBF4E73972DC98E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRT9</accession>
    <name>A0A2I2FRT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_441759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698631.1">
        <property type="nucleotide sequence ID" value="XM_024850393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRT9"/>
    <dbReference type="GeneID" id="36558092"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="93" mass="10491" checksum="A58C49766C799384" modified="2018-02-28" version="1">MIFIYHPNYRPSIRPTPSHPIARFGPYDLQLFLLVAISSIRTNDSTRSSDPWNHCFIGPWTIVEASRQVDSVSVHATAQSFPCPESQAPHQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRY0</accession>
    <name>A0A2I2FRY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_459790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698671.1">
        <property type="nucleotide sequence ID" value="XM_024851895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRY0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRY0"/>
    <dbReference type="GeneID" id="36559593"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459790"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF5">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="138"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="434" mass="47707" checksum="2F69FC8F79526FAD" modified="2018-02-28" version="1">MPDVLIQFTVAIVGGGIGGLSLAAGLLRRNVPVQIYEAASAFREVGLGLTIGPAALRAMPLIDPHIKEIYESLITMHADSPGYERFRETWFEVVWAAGEKSGDVLLDLKARPSGQTTVRRADFLDALVSVIPPEIAHFGRRLVQLVETSAGVELQFEDGSSATADIVVGCDGIHSKVKQTVIPDEYEQKLPQYSGMYGYRAVLDMDTMVQAVGDHRARVSTMYVGEGAYGITYPIMRAQKVNVGIYKLNDRWDNPEWVRPASKADMRRDLGHMGEYIGRLVEHMPDPSQWAIFEHPHISTYARSRVAILGDAAHASTPHQGAGAGQAIEDAHVLAELLGDPQVTHAAHAMAAFQGYDAVRRPRSQRVVTTSKENALLLCLCLDGVGSNEEKIQKSLQERLRWLWDVDVEAEVERGRKTMLDSPAFVVPSPSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTY7</accession>
    <name>A0A2I2FTY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_441525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699376.1">
        <property type="nucleotide sequence ID" value="XM_024850331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTY7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTY7"/>
    <dbReference type="GeneID" id="36558030"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441525"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB44074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="445" mass="49665" checksum="B1BCE657E36F7924" modified="2018-02-28" version="1">MGTTTSPEEVVPAAGQWPVDPQEDAPISEHRLWVDGCFDFSHHGHAGAMLQARKLGNELYVGVHSDEAILENKGPTVMTLHERVAAVEACRWVTCCVPHAPYVTYLPWVSHYGCQYVVHGDDITSDSNGDDCYRFVKAAGRFRVVKRTPGISTTDLVGRMLLCTKGHFVKSVQRTLTGEEGSGSEEERRLSSATLKQQICDYATDESGLQPGPHVWLWAGPSSAKFDNTVEESGCFETLVGGKPPKPGQRVVYVDGGFDLFSSGHIEFLRQVLAYEEAVGRERGWFDPEQRKKRLDECGEDYGPAYVVAGIHDDDVINHWKGLNYPIMNIFERGLCVLQCRYVHGVIFSAPFSPSEPYLKAMPLGVPDIVYHGPTTFIPLTYDPYSAPKKMGIFKETNSHLFQHVNAGEIVERILKSREAYEERQRAKLQKGIIEELEKSKEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU31</accession>
    <name>A0A2I2FU31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_392138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699413.1">
        <property type="nucleotide sequence ID" value="XM_024845962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU31"/>
    <dbReference type="GeneID" id="36553661"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392138"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="202"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="419" mass="46851" checksum="BDD7229C320487E4" modified="2018-02-28" version="1">MDRSNIIGRASEIAEVARTLADELARRQLPEPSFEHGLPAPLQSDAPDSEAPAARVKLLGLLDEFHDVLTEPALLGSPELRNPSMSVQALIRLGVIENFPSEGTTVQDLSSKLNLNENIVRRLISHAASYHVFFQSKHDFFVHTAASRVLSENAGMRSWMLIGLAETMPSAFQIADAVIQHPNSEEPQHSGWNMQNNTDLPIFRALADMPDRASRFANAMMWHAQLPGYSPQYLTECFPWGTGNLTVVDVGGGIGHISRALVAHDPTVQCIVQDRAEVVAQGDETLPADLKDRIRFQAHDFFQEQPVHGADVYLLRLVLHDWSNKYAQKILQALIPALKPGAKIVLNDRVVPGYGEAQLLVEREARDHDMYMLVLQNGQERTREDWDRLLRDTDPRFQLTNVSKPPKSYLAIVEVTWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU72</accession>
    <name>A0A2I2FU72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_467899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699439.1">
        <property type="nucleotide sequence ID" value="XM_024852501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU72"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU72"/>
    <dbReference type="GeneID" id="36560199"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467899"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="655" mass="72030" checksum="C137BFFE449EBDD8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUW7</accession>
    <name>A0A2I2FUW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_392656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699703.1">
        <property type="nucleotide sequence ID" value="XM_024845987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUW7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUW7"/>
    <dbReference type="GeneID" id="36553686"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392656"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="51"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="547" mass="59344" checksum="E5531C11E09F1ACA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV60</accession>
    <name>A0A2I2FV60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative long chain fatty alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_368335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699831.1">
        <property type="nucleotide sequence ID" value="XM_024844853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV60"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV60"/>
    <dbReference type="GeneID" id="36552553"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368335"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="270"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="578"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="747" mass="81008" checksum="753B9C0846AA0378" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVS7</accession>
    <name>A0A2I2FVS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic dynein intermediate chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_415448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700045.1">
        <property type="nucleotide sequence ID" value="XM_024847064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVS7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVS7"/>
    <dbReference type="GeneID" id="36554763"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415448"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000425">
        <property type="entry name" value="Cytoplasmic dynein 1 intermediate chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="507"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="687" mass="75522" checksum="31B208D86B8AF68E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWU5</accession>
    <name>A0A2I2FWU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_391688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700415.1">
        <property type="nucleotide sequence ID" value="XM_024845947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWU5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWU5"/>
    <dbReference type="GeneID" id="36553646"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_391688"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF20">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="572" mass="62334" checksum="E8AC3ABB8A5D7274" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWU9</accession>
    <name>A0A2I2FWU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_272493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700400.1">
        <property type="nucleotide sequence ID" value="XM_024843151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWU9"/>
    <dbReference type="GeneID" id="36550850"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_272493"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="175" mass="19507" checksum="19D5C8409DA92F18" modified="2018-02-28" version="1">MPISGGGILDSAALGRMGRMYDDRNFGRSPLPLLRTTSQLLCIRSRNSIRIPAATDLATRWVDAVCPQGWQPTTDVASHHSRKFGSYDVISEAELSPSTTKIFLSVMHYEIIGFWGEAWALGGGNNLCNVAFLFIYLFWIWFVQQRAASHNVESSIVLISSRSGVRSIISRLPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXA1</accession>
    <name>A0A2I2FXA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_513297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700572.1">
        <property type="nucleotide sequence ID" value="XM_024855093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXA1"/>
    <dbReference type="GeneID" id="36562799"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513297"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16353" checksum="F623405582891D20" modified="2018-02-28" version="1">MEDTFAAKERWVCERWRRRSDGCGIPGYKLQSDETAVSIIASATGIISSTSAPTSTSPAPSSTKTGSSHASHTNTGAIAGGVVGGVAGAAIIIALSWFLIRRMRRQRPQADEAILVSGPSKSVEISPAELDSNRVAELESRQDRPIAELPADYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXR2</accession>
    <name>A0A2I2FXR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_478378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700715.1">
        <property type="nucleotide sequence ID" value="XM_024853556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXR2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXR2"/>
    <dbReference type="GeneID" id="36561254"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478378"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="29"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="404" mass="44733" checksum="2BC1A304001BA016" modified="2018-02-28" version="1">MFFDAVEAGAPDVMYGLKIAADGDQSPLKVDLGVGIYRNELGAYNEMSVLRKAKDELYALNPDHDYEVTTGNPRYLANAAKVAFGGDSPVLDESRIASVQTISGTGSIHLALMFLARSPEGKNRQVYIGTPAWGNYVPMCNLAGLETKTYTHYNPATGGVDFPSVLDAVRTADVGSVFILQGCCHNPTAADFSREQWRTLAVEMKNHHLLPLFDIAYQGLGDGLDEDSYSVRYFAQMGFEMIVCQSFSKSLGLYGERVGVCHVVCASRSHVYPVHDQLRCLIRWEFSSSPAYGSRLVDLVLSDPLKEAEWNSELSLIRSRLRSIREALFRQLNDVLKVPGNWGIILQGKGLFCLLPLSPEQCKDLREKHHIYIVPNGRITLSGLSDRNIEYVGRCISQVVEDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXZ9</accession>
    <name>A0A2I2FXZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNA excision repair protein Rad2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_413773</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700805.1">
        <property type="nucleotide sequence ID" value="XM_024846992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXZ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXZ9"/>
    <dbReference type="GeneID" id="36554691"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413773"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000092">
        <property type="entry name" value="DNA excision repair protein Rad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="813"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="608"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1060"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1060"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB45503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1122" mass="126119" checksum="098A0C0492560F99" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY46</accession>
    <name>A0A2I2FY46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_245155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700808.1">
        <property type="nucleotide sequence ID" value="XM_024842978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY46"/>
    <dbReference type="GeneID" id="36550677"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_245155"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="149" mass="16599" checksum="7AC2CF2DD8F9BE61" modified="2018-02-28" version="1">MGSCLQSHHPSIPFSHRGPATQYAPSRVRPDQPTGHAIRTGRLNSFLFLAQVASPAKENRSYQMTRVGVGVTRDKLGIVQKDAGLSDQLPSWAITSGRSEEWFYEPDTNHIIRSRHSIRYAPLSRITCFSLPGGTHRLARRGPVICHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY89</accession>
    <name>A0A2I2FY89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_247104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700901.1">
        <property type="nucleotide sequence ID" value="XM_024842998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY89"/>
    <dbReference type="GeneID" id="36550697"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_247104"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014160191" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10004" checksum="FC67784D0D2B2A68" modified="2018-02-28" version="1">MKRISYSQLIKSILVFLSSSIFSSMSPCPCPKSIVIPPVHPLIVFPFLSFPLFSSPNRPIKPASPDALLGLNFFMIFIRGVRVPNERGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY92</accession>
    <name>A0A2I2FY92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_245371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700818.1">
        <property type="nucleotide sequence ID" value="XM_024842981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY92"/>
    <dbReference type="GeneID" id="36550680"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_245371"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="82" mass="9499" checksum="1C9DD658EBC69FFF" modified="2018-02-28" version="1">MTMLSPDDADVGISLLVPRPLVHLCFFFFSFCFFSPSASVFSFLVAYFPGGYQCEYQYLPNTVVEDIPMEMRRSPEWIRANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY96</accession>
    <name>A0A2I2FY96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700916.1">
        <property type="nucleotide sequence ID" value="XM_024849819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY96"/>
    <dbReference type="GeneID" id="36557518"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439353"/>
    <dbReference type="OrthoDB" id="5372935at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33194" checksum="727F44DF103FDFA5" modified="2018-02-28" version="1">MASAGLSAALEKVHLDQDDHEDVQEKLAAPSLPGPFRFFDLPSEIRLRIYSFVLFTPRRRKKALRANGSVGASSKNPPRSQMSHRINLYLVSRRMHNEATDFFYSSQIFRLFHIQDYCRLPTIRSISSRYLPSIATLELILGSSWTAPPDSWTVNRELGLEEMTRVRTFKIFIECDPSHPVFEGFRISEGFYTDFAGEIVQQSLKRLPNVVHVEFDAYPSVRKSGALMRRLLQETRSASKQIVWGPVRGWTDFDGEETPKRNLIYELNLDESSRNDPVTQRRLRILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYL0</accession>
    <name>A0A2I2FYL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_478660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701021.1">
        <property type="nucleotide sequence ID" value="XM_024853581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYL0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYL0"/>
    <dbReference type="GeneID" id="36561279"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478660"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="310"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB45719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="401" mass="45573" checksum="5FB6B285B5F68A63" modified="2018-02-28" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVIDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGTLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFSIYLNYTRSLRFDDKPDYSYLRKIFRDLFVRESFQYDYVFDWTVYKYQKNAAMIVDASNKKDKEAEEQQRRQGVAGAPMGTPGAAAKPGGISSQRRKVIDRGTLDNTPDTNRAVGGSDRMLRSASKVASGAYGPAGSRAKRDDGYGAQWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ65</accession>
    <name>A0A2I2FZ65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_364180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701148.1">
        <property type="nucleotide sequence ID" value="XM_024844629.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FZ65"/>
    <dbReference type="GeneID" id="36552329"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364180"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12299">
        <property type="entry name" value="RRM4_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000632">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000633">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000523">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000588">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000711">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="834"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="910"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="1001"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="1118"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="767"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1248"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB45846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1282" mass="143228" checksum="EF28620260701359" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZI8</accession>
    <name>A0A2I2FZI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_365144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701347.1">
        <property type="nucleotide sequence ID" value="XM_024844687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZI8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZI8"/>
    <dbReference type="GeneID" id="36552387"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365144"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="346" mass="37925" checksum="B562082D22F5DDB7" modified="2018-02-28" version="1">MSNALPYLQKLRKSQLVDWAEATDLKDYEDLNKPELVTTLDDHLQSNQSIFATDDRLAEYYRRLSQSPRLSPTKREPKLESPTKVSPTKLEAPRSVRRGRKAKEEIEQTDDSDVSPQAIATTTPGRSPLVTVQPPLPPSPAVVTDAIDRQTAAWGERIGDAWTALGVRERSHALRSILSSAKAVEILFVALEGAGLFRTLLPLAYVATVPAVEAINSPEIPISVPDLFKLVEGTFWAPLSLWLLTSLFLPLTAAYFFNLSGQTSGGPALNTRRNRAAQATFDPLSFNIAKALISYLVYANRFTFWNVFSDASIATVNESVPGQWAGILTGSAIGTIGTLYEAILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G021</accession>
    <name>A0A2I2G021_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_390772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701532.1">
        <property type="nucleotide sequence ID" value="XM_024845917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G021"/>
    <dbReference type="STRING" id="1392250.A0A2I2G021"/>
    <dbReference type="GeneID" id="36553616"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_390772"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF222">
        <property type="entry name" value="ADAM FAMILY OF METALLOPROTEASE ADM-A (AFU_ORTHOLOGUE AFUA_6G14420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="7">
        <location>
            <begin position="252"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="6">
        <location>
            <begin position="477"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="726" mass="77965" checksum="BAAC8AB6C0BC1548" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G026</accession>
    <name>A0A2I2G026_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701521.1">
        <property type="nucleotide sequence ID" value="XM_024849935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G026"/>
    <dbReference type="GeneID" id="36557634"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439873"/>
    <dbReference type="OrthoDB" id="2151982at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="177" mass="19774" checksum="E0FE78F7DEC81905" modified="2018-02-28" version="1">MDISQISTQLSPTPKAFPNCCLSISRTLTSHLASLLPKKPSFTVSIGSGSGLLEALISHRHSDVLIEGVEVNSTVNRYILEPDMNVVHGTWDLHPRVREAAAWMFVYPREPKLVSKYLETFSADEVEIIVWLGPRADWVDYEPCFRASMFSDVQVYEDVGVAGFEMLVVMRKSDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G066</accession>
    <name>A0A2I2G066_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_415228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701579.1">
        <property type="nucleotide sequence ID" value="XM_024847053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G066"/>
    <dbReference type="STRING" id="1392250.A0A2I2G066"/>
    <dbReference type="GeneID" id="36554752"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415228"/>
    <dbReference type="OrthoDB" id="5392033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF5">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="435" mass="48251" checksum="A12400E54678DE32" modified="2018-02-28" version="1">MPIMQTTIPPPEVESQEAGKSLAVQYWREYIRSVMVPLFHATGSYTSAEQESHLQFMDKLVAPNLGPLPTEPHGPYTPPASLVGSPFDPSLNMAASGKAKARFDFDIVGPAQRTGSDPFAEHAARKVALHIASKTGSSTQWLENLFTTLFLSPEETQTVVTQMPADIAAPPLSVGVDFDGSQRVMKCYIHGVRKSVATGRSSTDILLQALRNLEPMGDSLSAGVELLEDYLSTTPNDAVLMLLGIDCLDPTLYPETRVKCYLHTRSNSFSVARDVMTLGGRLDDETSRARIELLRSIWSILRNEPDDVPMDEEWSKPDRIGSTGYSGLQFTIEIAPGHTFPDTKIYVPVFQYAETTQEVERNVELMLQKLGNEWGLTGRYRKTMQTIFGSETDYGQTYVSFAYSKTKGAYTTSYFARPIRQVDTKLAGYFGIRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0B4</accession>
    <name>A0A2I2G0B4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_439918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701616.1">
        <property type="nucleotide sequence ID" value="XM_024849947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0B4"/>
    <dbReference type="SMR" id="A0A2I2G0B4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0B4"/>
    <dbReference type="GeneID" id="36557646"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439918"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="497" mass="54247" checksum="3043797B388C609A" modified="2018-02-28" version="1">MAALSTTIETPLVKYEQPLGLFINNEFVKGSEGKTFETVNPTNEKVITSVHEATEKDVDIAVAAARKAFEETWRQVTPNERGRMLTKLSDLMERDIDTLSAIEALDNGKAFTMAKIDVANAANCIRYYGGWADKIHGQTIDTNPETLVYTRHEPIGVCGQIIPWNFPILMWAWKIGPAIAAGNTVIIKTAEQTPLSGLYAATLIKEAGFPPGVINVISGFGRVAGAAISSHMDIDKVAFTGSTLVGRQVLQAAAKSNLKKVTLELGGKSPNIVFDDADIDNAISWSNFGIFFNHGQCCCAGSRILVQEGIHDKFVARFKERAAQNKLGNPFDQDTFQGPQVSKLQFDRIMEYINHGKQSGATVAHGGERHGDEGYFIQPTVFTDVTSDMKISQEEIFGPVVTVQKFKDEAEAIKIGNSTSYGLAAAVHTKNVNTAIRVSNALRAGTVWINNYNLISWQAPFGGYKESGIGRELGSYALENYTQIKAVHYRLGDALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0N1</accession>
    <name>A0A2I2G0N1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701744.1">
        <property type="nucleotide sequence ID" value="XM_024849549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0N1"/>
    <dbReference type="GeneID" id="36557248"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438236"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="302" mass="34569" checksum="2B855811E26AF80B" modified="2018-02-28" version="1">MERLIFNRNHTPKSIVPIIGEILDNNYIPNVLVGDAMLGIMGAFIFPRCLQFVVPDDKIDVAITTLIAAGFPRCDDSRGCRRYSTHFPLATAHFHLWDDEEAGTTNPGKLCIFQKSDMLPSFPSLPFYISDCNDPYFMTITDDRLPDAPADEDLFGRYPMDTYPVRIPVPVKACEAAMLLYCRDQELQLNNAAWEVWLILLGKYVSQSSLYQIGRTVDKDGNEENPYLGYWNEVKGSQNRGWPRSLAKLRLKVLREQELSILAGVEIPEKEEDTEEDTEEEDQQESPVTPVRDYESFEKWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1U6</accession>
    <name>A0A2I2G1U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_477710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702149.1">
        <property type="nucleotide sequence ID" value="XM_024853496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1U6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1U6"/>
    <dbReference type="GeneID" id="36561194"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477710"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000052">
        <property type="entry name" value="Alpha-L-rhamnosidase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF5">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014112850" evidence="1">
        <location>
            <begin position="23"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="253"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="588"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="682" mass="75056" checksum="AE3270CCA78F1127" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G208</accession>
    <name>A0A2I2G208_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_363768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702201.1">
        <property type="nucleotide sequence ID" value="XM_024844605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G208"/>
    <dbReference type="STRING" id="1392250.A0A2I2G208"/>
    <dbReference type="GeneID" id="36552305"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363768"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="328"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="590" mass="62831" checksum="9508BD15C684E6B1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2A9</accession>
    <name>A0A2I2G2A9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_438719</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702308.1">
        <property type="nucleotide sequence ID" value="XM_024849669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2A9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2A9"/>
    <dbReference type="GeneID" id="36557368"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438719"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="56"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="153"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="259"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB47006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="355" mass="39167" checksum="E389A8AB63FA8C55" modified="2018-02-28" version="1">MSLDRHKPASTDETNRPPDDKPPIRSQFPSSPDVMKGRGPDDTTPFLVDLKRRISEPVVAAFVAGGVAGAVSRTIVSPLERLKILLQIQTVGREEYRLSIWKALVKIGKEEGWKGYMRGNGTNCIRIIPYSAVQFGSYNFYKRFAEPHPGSDLSPMRRLICGGAAGITSVTITYPLDIVRTRLSIQSASFAALGHRGTSDRLPGMFRTMVLIYRNEGGIVALYRGITPTVAGVAPYVGLNFMTYESVRSFLTPEGEKTPSSMRKLLAGAISGAVAQTCTYPFDVLRRRFQINTMSGLGYKYKSIWDAVRVIIAEEGPRGLFKGIVPNLLKVAPSMASSWLSFELTRDFLVSLDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2I1</accession>
    <name>A0A2I2G2I1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_388294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702395.1">
        <property type="nucleotide sequence ID" value="XM_024845837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2I1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2I1"/>
    <dbReference type="GeneID" id="36553536"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_388294"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB47093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="277" mass="30077" checksum="652339D94D526D64" modified="2018-02-28" version="1">MSSKSQLTYSARASTHPNALAKKLFEVAEAKKSNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSEETITGLKALSQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTAESPDFPYGSERGLLILAEMTSKGSLATGAYTTASVDYARKYKGFVMGFVSTRSLGEVVSENSQASGDEDFVVFTTGVNLSSKGDKLGQQYQTPESAVGRGADFIIAGRGIYAAEDPVEAAKRYQEEGWKAYLARVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2W3</accession>
    <name>A0A2I2G2W3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_478071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702512.1">
        <property type="nucleotide sequence ID" value="XM_024853525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2W3"/>
    <dbReference type="GeneID" id="36561223"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478071"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="97" mass="10597" checksum="308A579A20C447B8" modified="2018-02-28" version="1">MESQALCLNERIGPLENQREFALAFGGPSSKVGFRKSWSMVSSIGKGSDLDSMEYVAPAVEYRVAELKVLENFSVINILSAFQEGGYEKEKLADACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Z9</accession>
    <name>A0A2I2G2Z9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_448902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702552.1">
        <property type="nucleotide sequence ID" value="XM_024851003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Z9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2Z9"/>
    <dbReference type="GeneID" id="36558702"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448902"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="265"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB47250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="636" mass="69631" checksum="07295294FF3B7027" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3Y0</accession>
    <name>A0A2I2G3Y0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_409761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702880.1">
        <property type="nucleotide sequence ID" value="XM_024846808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3Y0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3Y0"/>
    <dbReference type="GeneID" id="36554507"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409761"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014115662" description="Arylsulfotransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58140" checksum="0CF703DE9EE6CE6C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4T5</accession>
    <name>A0A2I2G4T5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_465415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703192.1">
        <property type="nucleotide sequence ID" value="XM_024852326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4T5"/>
    <dbReference type="GeneID" id="36560024"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465415"/>
    <dbReference type="OrthoDB" id="5366485at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="249" mass="27075" checksum="76E4FBC473C14362" modified="2018-02-28" version="1">MHKWQGIRRAHCVIDRISSRASTSSSASRHSRQYHHQASFQTHPQRQTLLITSTRQFAHLPSPRVSHSTIITRNMSSDDAYMSFLNKANADLNTARNQPSENVSSAVARTETVDAGVRVPAPLTSVDAFYISETDEPFEPVTLKWDGASRGLWPDAAHLSSLISPSTDLSSSITTLPASSFDPKNQYPGPLRAVRAAVAQASGGGIDESAVEVKAYRVEVGTSRVEYYLVALDAEQGLLVGLRAKAVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G525</accession>
    <name>A0A2I2G525_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_361566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703276.1">
        <property type="nucleotide sequence ID" value="XM_024844474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G525"/>
    <dbReference type="STRING" id="1392250.A0A2I2G525"/>
    <dbReference type="GeneID" id="36552174"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361566"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="72"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="170" mass="18618" checksum="8A17173CF08EC2C5" modified="2018-02-28" version="1">MSPPRTRAPARQLDEFEESVYEYSNRISWDDSEEHWDIDRSSNIRFESATRGPPARVSFQFTVAPKLCNLIGNLHGGCAATLIDVLSTCILLGVSSPGHFGLGGVSRHLKVTYLRPVPQGTEARLTCELVHVGKRLAFMKAEISRVDTGALCIIGEHEKANTDPEAGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G548</accession>
    <name>A0A2I2G548_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_361585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703296.1">
        <property type="nucleotide sequence ID" value="XM_024844476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G548"/>
    <dbReference type="STRING" id="1392250.A0A2I2G548"/>
    <dbReference type="GeneID" id="36552176"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361585"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="188" mass="22065" checksum="69BB3875A8DACB0A" modified="2018-02-28" version="1">MDVPEPEQSPFTAVTAQTSKLARQYQTYLDASTPFTVYRWVGTALLLVIFFLRIVLAQGWYIVAYTLGIYLLNLFLLFLQPKFDPSLTQDEGLEDGDAAASLPTKQDDEFRPFIRRLPEFKFWHSATRAIAIGFLCSWFTFFDIPVFWPVLVVYWIILFVLTMRRQIQHMIKYRYVPFSFGKTRYGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5H3</accession>
    <name>A0A2I2G5H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_465594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703428.1">
        <property type="nucleotide sequence ID" value="XM_024852332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5H3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5H3"/>
    <dbReference type="GeneID" id="36560030"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465594"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB48126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="283" mass="31402" checksum="C5A24F114293AC1C" modified="2018-02-28" version="1">MSLPRLSHSLRTAESLLTRAPPARFLPRRTFTQSAVSRQQQPPRPAAPNGSSSTPTTPKPTSPAPSPAEERAARIVAQTPSHQTTANISKTGLSDKPLELDVSAEEKIDWTRSFHGLSAAPFPKEAADILLAPCDPAEVEIKPDGILYLPEIKYRRILNRAFGPGGWGLVPRSESIVTPKTVTREYALVCNGRLVSVARGEQDYFSPDGIPTATEGCRSNALVRCCKDLGIASELWDPRYIRKFKAEHTREVFVEHVLNKRKSKIWVRKDDPVSYPWKESNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5I2</accession>
    <name>A0A2I2G5I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_410728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703405.1">
        <property type="nucleotide sequence ID" value="XM_024846855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5I2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5I2"/>
    <dbReference type="GeneID" id="36554554"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410728"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="236" mass="26643" checksum="B15BF805E44F6397" modified="2018-02-28" version="1">MNPYLRSSPVFSRASALTLRPAGFPRTAELARRYATQSDMGRGAPGTATPRRRNVTVLSDDGRYEWGELSGREKAARATQQSINFVVVLAGAVLTGGVFYLLYTEVFSPNSRTWQYEKAVERILNDTRCTDLLGDRREIRAFGENTSSRWARNRPIASSVEKDRLGREHLKMNFHVEGPRNAGVVFVHMIKPHDQHDWQYQLLALDVNGHSRIVLEQAPEKPGVGKALKLLGIQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5V4</accession>
    <name>A0A2I2G5V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_209009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703551.1">
        <property type="nucleotide sequence ID" value="XM_024842803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5V4"/>
    <dbReference type="GeneID" id="36550502"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_209009"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="163" mass="18661" checksum="84B6F911A962D91E" modified="2018-02-28" version="1">MEMLRTLVPFFVCLPSDCNPSTGLTPFRGSLFSHLSFLVIFGMFTFFLWNFVSSSPRPTRLPLSRLTYRNKENPPNDDSCPTGYDLSSGTEFPALSIDLQYQSQEMLPCPITHYRETASFRRMENNTRHIVPYHSSLVDGCPLASLLKKLLRKHRESTDTGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6E8</accession>
    <name>A0A2I2G6E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_386948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703756.1">
        <property type="nucleotide sequence ID" value="XM_024845790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6E8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6E8"/>
    <dbReference type="GeneID" id="36553489"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386948"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="301" mass="32549" checksum="506535F202866D3A" modified="2018-02-28" version="1">MTFDGLYAPLQNTEVFDVSDCVAVVTGGGTGMGLMMAKALEANGAKVFILGRRLEVLQEAAKQSTFGNISPVQCNITSKDDLQKAVDHIANEEGYVTLLVNNAGIATPNLGPHHTRPNAKWDVSAVRKYWFDRSFADYAKVMEANTIAPLQVSFAFLELLDQGNKVRADQAKAKGRKDYVRSQIVMLSSVGGFGRDNSAFIYGASKAGTTQMTKNLSTYLFPWKIRANVIAPGYFHTEMTDSFHKTTGGKLPASMAPEERFGDMQEIGGTILYLASKAGAYCNGSVMLADGGYLGNHPSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6H2</accession>
    <name>A0A2I2G6H2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_438087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703772.1">
        <property type="nucleotide sequence ID" value="XM_024849507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6H2"/>
    <dbReference type="GeneID" id="36557206"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438087"/>
    <dbReference type="OrthoDB" id="10317872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="141" mass="15548" checksum="0DD25E6A13491CD0" modified="2018-02-28" version="1">MTSVVHIMCGGPDDTEYRLNAVVIPNLPCDILTPLGRQELPFPAIQRGQAPRVVEHAQGSFVVRDSVRLHIWLDGTGTSDTRDFYIPIHEAGVIPALPQQQQDCPIHMIIGRDCVLDWDAYDGQNAPILSIGLARKTPAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6K1</accession>
    <name>A0A2I2G6K1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_465830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703809.1">
        <property type="nucleotide sequence ID" value="XM_024852358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6K1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6K1"/>
    <dbReference type="GeneID" id="36560056"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465830"/>
    <dbReference type="OrthoDB" id="4218675at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="67"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="415" mass="45694" checksum="81F480A995126C68" modified="2018-02-28" version="1">MGSLILVPKMALGFRGLAVTTLCIALVTVFCVCPLYFMGDPYPLVKETQKIQKAAFTTPLTIQNNYFIVDFTLGSPPQPFRGVPAISWRPVVLAPASYELEEDVQYIEEHGKEYPHKYNSSLSSTAVVSDTLVATGDRMLLSGVGNMSYETLNVAGIQAANQSFVALSGIGQEIPSLLHIMYGGYGLFDGAIGLSPSNRPSKSGLESLWMNIARQDILDAHILSLKPPRPGSSELGEMAFGITEDYQRLADRLVRMKVEMNSVSREFIEPWQVEGRAIYSGSNQMQLQPGNHTVRFSTETPLLLLPKESIRDVLNATRTIVTDNKGWSVPRLPCEARADIPDVTIDIGGHNFTITPYDFLSEVRYSDGSVECAPQIGTSDGNFLLLGGPFLKKFYSVWDRDNMEIGLAPLSELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6R8</accession>
    <name>A0A2I2G6R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_438145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703870.1">
        <property type="nucleotide sequence ID" value="XM_024849521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6R8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6R8"/>
    <dbReference type="GeneID" id="36557220"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438145"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="13168" checksum="142F129472A4E7B0" modified="2018-02-28" version="1">MSSSEPVKGMRKNGKNWHDNKKPFRPTSGMTSYAKRLEARKHQEAVKEHEKELREEKEAERKAHIQHIRDRRAAKEEKERYEKMAQKMHHKRVERLKRREKRNKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6Y9</accession>
    <name>A0A2I2G6Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-amino acid oxidase LaoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_358625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703944.1">
        <property type="nucleotide sequence ID" value="XM_024844306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6Y9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6Y9"/>
    <dbReference type="GeneID" id="36552006"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358625"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.240:FF:000001">
        <property type="entry name" value="L-amino acid oxidase LaoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014148980" evidence="2">
        <location>
            <begin position="17"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="570" mass="64514" checksum="741D89F21A4E256E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7R9</accession>
    <name>A0A2I2G7R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_464504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704226.1">
        <property type="nucleotide sequence ID" value="XM_024852254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7R9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7R9"/>
    <dbReference type="GeneID" id="36559952"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
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            <begin position="35"/>
            <end position="44"/>
        </location>
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            <end position="54"/>
        </location>
    </feature>
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            <end position="87"/>
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    </feature>
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        <location>
            <begin position="172"/>
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        </location>
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            <end position="311"/>
        </location>
    </feature>
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            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="695"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="79271" checksum="3D9DDB63DEF76121" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7T2</accession>
    <name>A0A2I2G7T2_9EURO</name>
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        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">IBT 23096</strain>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006351">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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        </location>
    </feature>
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            <end position="521"/>
        </location>
    </feature>
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        </location>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="115639" checksum="DAC5443379053144" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G864</accession>
    <name>A0A2I2G864_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_436731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="PLB49077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_024849209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G864"/>
    <dbReference type="GeneID" id="36556908"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436731"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="97" mass="10957" checksum="512F8D27E5DAA0EA" modified="2018-02-28" version="1">MLPHGGGLLGQQSKKRTYFDSGDFAVSSADRVTDMEMLRLAPPILNDKVFRSHMPLFLTLETSIKMPIKTFVPKAVRKKQLRVHFVCNQIPMNAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8I1</accession>
    <name>A0A2I2G8I1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_357278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704476.1">
        <property type="nucleotide sequence ID" value="XM_024844210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8I1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8I1"/>
    <dbReference type="GeneID" id="36551910"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357278"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59814" checksum="4BD4AB9D60697B5F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8Z3</accession>
    <name>A0A2I2G8Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_358514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704658.1">
        <property type="nucleotide sequence ID" value="XM_024844299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8Z3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8Z3"/>
    <dbReference type="GeneID" id="36551999"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358514"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="514" mass="55905" checksum="5FBF631021886A7A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9T1</accession>
    <name>A0A2I2G9T1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_475934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704942.1">
        <property type="nucleotide sequence ID" value="XM_024853302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9T1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9T1"/>
    <dbReference type="GeneID" id="36561000"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475934"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="320" mass="34597" checksum="A5A1F1F19061F8B3" modified="2018-02-28" version="1">MTVPPKQKSPPPGIYCPVISLYTSTDRQDIDLEASSKFFSYLISSGIDGLVLAGTTAEAALLSADERKDLVQTARKAAVDLGRPDLPIMAGISGQSTNESIRLAQSAWDAGADYGLLLPPNYWPKAVSRDIILDFYRAVADATPLPIVIYSFPAVTNNIDLNSDLLSSLAEHPNIVGVKLTCGNAGKVTRLTNKYTHDQFAVYAGSSDWLIPCLSGGGSGCVTGIANVFPRTVAHLYDLWKKGEVQEARQLQGVVAEAEKACKEGIAPTKYAAAYFVGDAVGIQERAFWPRRPYRAVGEVVRKWVVEVMGFLEGVERSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9U4</accession>
    <name>A0A2I2G9U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_357822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704925.1">
        <property type="nucleotide sequence ID" value="XM_024844248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9U4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9U4"/>
    <dbReference type="GeneID" id="36551948"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357822"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08296">
        <property type="entry name" value="CAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="17"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="341" mass="35989" checksum="8868F1BC8871B488" modified="2018-02-28" version="1">MPALPKTYKAWVLASVGAPLELREVELKLPAAGEILVQVRACGVCFTDVAVQKGELGDDLFPRVPGHEIIGDVVAIGEGVQGFCLDQRIGGAWLGGHDNVCRSCRRGLFQACSNAVYNGASRDGGYAEYVLLRAEAAVPVPKDMNPAEAAPLLCAGLTVFNAIRKMHVEQGSLVAVQGIGGLGHMAIQYARKMGYKVAVLSSSAAKKDLALELGAHEYIDTGSEDAVKSLQRLGGAALILATASHGKAVTPLTAALQPSGKMLLLSPSGSMEFNTNDLIMGTSAIQGWLTGNALDAEDTIDFAKTFGIKCMIERFAFQDALKAVDYMTSGSVRFRGVLVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9V3</accession>
    <name>A0A2I2G9V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyl-aminoimidazole-succinocarboxamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704950.1">
        <property type="nucleotide sequence ID" value="XM_024849313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9V3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9V3"/>
    <dbReference type="GeneID" id="36557012"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437219"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="348" mass="38930" checksum="B7D5C1B52B5CC5C7" modified="2018-02-28" version="1">MASRGGIFLTISSTSEPNSLILHDTIYGTHTITEPILIDLLQCPSLTRLKGVNQHGITSLLHLSPPVTRYEHSVGAFLLVRKVGGSLDEQIAALLHDVSHTVFSHVVDYALSNPGESFHETEKEEYLAGTEIPDLLTKYGISQDVLKEELYPLVERDAPRLCADRLDYALRDTVAVHNLPCADAKRIYEAVAAAPDAMDADRVLVLPDAQLALKLARAYQITDESLWCNPALVDMYREVGQVIGDMVRRQRISLAALWKWSDEVLWMFLSVNAEVERSTVIKDVEAHAKRVKENKPEGLRLPKGAKVRTIDPDVLVEGKIQPLSEVVPEWGVERQEYIARREAEREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAT2</accession>
    <name>A0A2I2GAT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_435252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705296.1">
        <property type="nucleotide sequence ID" value="XM_024848898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAT2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAT2"/>
    <dbReference type="GeneID" id="36556597"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435252"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="461" mass="51420" checksum="DAB52BC9F140F0FE" modified="2018-02-28" version="1">MWCVVIPREGAYGDAYQLAAYRGSDKVLEMLLARYKPDDGRMYRYGPFKSPIGAAAAKGHVNAVRLLIRWKLTGVVVRYPFKQTPLFLAVNRGHIGVVELLLKEGIEDPRSIDTFGYTPLSLAVRRGHETLVKFLLKFHELYPGCRKICPNQGMRGQLPLQVAVQRRLSGMAKLLLGRYDTDPNCQNEKGGTPLMIAIESNQMEIVRCLLSDHRTVQVFRNHEGMTYLMHAAWQRISNTMQPRAAMPTNLNLKTNDGRTALHIAVQKGTKESIDLLLSRNDIDPNAQDIYLSSALHYAACYGCFPAVQSLLSHPSTNPNLLDKQMMTPLYIAVAEGHVEIVRLMIKHSNTNVNCQCSTRASTPLIRAVRENNTEMIQVLLTSSRVDKDVQDYRGDTALTIAASSRRTIIAQLLLQSPLPNLDLTTLDGMSALRLAIEAGSTEIRRLLINHGAEARLPPDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBZ9</accession>
    <name>A0A2I2GBZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_381074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705716.1">
        <property type="nucleotide sequence ID" value="XM_024845553.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GBZ9"/>
    <dbReference type="GeneID" id="36553252"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381074"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000494">
        <property type="entry name" value="Sister chromatid cohesion protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1369"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1703"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1703"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1743"/>
            <end position="1756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1768" mass="196018" checksum="8C07F15B0FB719EF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC77</accession>
    <name>A0A2I2GC77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_474037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705790.1">
        <property type="nucleotide sequence ID" value="XM_024853100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC77"/>
    <dbReference type="GeneID" id="36560798"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474037"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38894" checksum="7C84513F4DCACCF2" modified="2018-02-28" version="1">MDTDAYPQSGTLFRPPAKRRKFLRRRADNMPEESDSMSGAGDSLPEAPRSRSQSPRDTPRETASSADLIRRRRLHRARRGGIEFSATSRQTTDVANQSALSSASTEELEAERIKTMCDRFTAHTGQTVDVDRHMMTYIESEMAKRNQRAMPMDAADSDAIGTKEASGAPSSSDLPQREPASLGKLHEIDLGQETKLENIARTEAATRRLADGDREEDAQPRDDESLAKSTPTRRDNRSWRHQKRRTSEDVQRDRLVEEVLRESRLDVYDEPAEEITVAADDQAADDRVAEQFRRDFLDAIQSRRRVARARNTKTTKPEAPRGPKLGGSRSARAAMREMQDKSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCA2</accession>
    <name>A0A2I2GCA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_455007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705810.1">
        <property type="nucleotide sequence ID" value="XM_024851493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCA2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCA2"/>
    <dbReference type="GeneID" id="36559192"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455007"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="567" mass="61963" checksum="3E0BDDF5278C8C64" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCC1</accession>
    <name>A0A2I2GCC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium permease family membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_474091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705833.1">
        <property type="nucleotide sequence ID" value="XM_024853102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCC1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCC1"/>
    <dbReference type="GeneID" id="36560800"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474091"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000017">
        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="873"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="905"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="942"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="487"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="873"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="745"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116909" checksum="07A9DF964FEE6C8F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCI5</accession>
    <name>A0A2I2GCI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase activator Bem1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_445869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705893.1">
        <property type="nucleotide sequence ID" value="XM_024850746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCI5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCI5"/>
    <dbReference type="GeneID" id="36558445"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445869"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000184">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000250">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="318"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="518"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65940" checksum="0605D1E17D740737" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCM8</accession>
    <name>A0A2I2GCM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative serine peptidase, family S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_445945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705935.1">
        <property type="nucleotide sequence ID" value="XM_024850748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCM8"/>
    <dbReference type="GeneID" id="36558447"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445945"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000636">
        <property type="entry name" value="Serine peptidase, family S28, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF109">
        <property type="entry name" value="PEPTIDASE, FAMILY S28, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB50633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="547" mass="61181" checksum="7AA9E11CA7A9D5A8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCU9</accession>
    <name>A0A2I2GCU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_152315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706018.1">
        <property type="nucleotide sequence ID" value="XM_024842527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCU9"/>
    <dbReference type="GeneID" id="36550224"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_152315"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="12116" checksum="77AFD0CACEDC3B43" modified="2018-02-28" version="1">MVFSPGLTGWEKRRGGGWLVLVLVCSGSPNRSFASCHPGRQGQRQRARGRHFPGFSVLRGYPRSNADVVRAVKKISSDLWTTPISLCLCLFISPTPSLSSIYPSTPQVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD18</accession>
    <name>A0A2I2GD18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_508910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706081.1">
        <property type="nucleotide sequence ID" value="XM_024854616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD18"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD18"/>
    <dbReference type="GeneID" id="36562322"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508910"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF22">
        <property type="entry name" value="ENDORIBONUCLEASE FAMILY PROTEIN BRT1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="132" mass="14101" checksum="7F448108A5C5FFCE" modified="2018-02-28" version="1">MSFNRAENAIQCPGAPKSNGKYALVIKHGNVLHLSGWMGQDPETGKVVEGGAVAQMEQATRNIETCLLAAGSSLDKIISRRLFITDMSKVFEVDDAWGRLLKPPYPVSTAIGISSLTQKGAIIELEVTAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD35</accession>
    <name>A0A2I2GD35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_381822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706073.1">
        <property type="nucleotide sequence ID" value="XM_024845583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD35"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD35"/>
    <dbReference type="GeneID" id="36553282"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381822"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="218"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="707"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="864" mass="95195" checksum="60A65FD17D65D989" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDE1</accession>
    <name>A0A2I2GDE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_446108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706220.1">
        <property type="nucleotide sequence ID" value="XM_024850767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDE1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDE1"/>
    <dbReference type="GeneID" id="36558466"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446108"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF30">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB50918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="285" mass="31570" checksum="25E99D55DC097D93" modified="2018-02-28" version="1">MHSCTPELAYIEYLPSIGGNAFFLALFSILLLMQMILIYYRAWAFSSTMVCGLILEILGYIGRIKLHNDPCQFTDFLLYLVCLTIGPAFFGAAIYLCLGRIIIIHEGEDVSRLRPRSYTIVFVTCDVISLILQAAGGAITSSATDNAVRDMGVKVMIAGLAFQVAALGLFMAFGVDFAVRSNARFVRFRPTEPRKTPNPEFVAIRAGKKWKLFLIGISTATVTIFIRSFFRVFELNGGFHSRLANNEPALMVLDGAMVSVACLWLTVMHPGVVMARRWNTVKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDF0</accession>
    <name>A0A2I2GDF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligoxyloglucan reducing end-specific cellobiohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_474470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706227.1">
        <property type="nucleotide sequence ID" value="XM_024853147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDF0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDF0"/>
    <dbReference type="GeneID" id="36560845"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474470"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014171275" evidence="1">
        <location>
            <begin position="26"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="366" mass="39959" checksum="FD8C3AE6CC00F635" modified="2018-02-28" version="1">MGSTRLPLTILTLLFFHILLPIANASPSVITKREVRVDVKAGTMGAGTYPRATYIKDKSLLGCFRSYKGDKLAIETVRSTDRGKTWKPVGTAITELKKEYGLNNCYLHQLPDSDRILLAFRNPQRDAADTKYVKHIMLVYSSDDGGKTWAPLSTVATTETTGLGLWEPFMMEGLDGDLMLFYSRETRTDGKDQNSILVRSTDGGKTWGKEQTISGGDIQKRDGMLGVARVAKGSKKLIAVFESLTPNTGITSITSDDDGKTWGNRKLVYKGTNGPPSEAAPQIVRVGEKTLVVSFSTWEDDREAGKSKPPNVKVVVSTDGGATWGQKTLVHENCHWAGEVAVDGNSLLVMCDHNDGTSVSMRVSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDN0</accession>
    <name>A0A2I2GDN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_425210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706219.1">
        <property type="nucleotide sequence ID" value="XM_024847614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDN0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDN0"/>
    <dbReference type="GeneID" id="36555313"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425210"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="246" mass="26980" checksum="4868799A99976696" modified="2018-02-28" version="1">MGVSSQQALSIVVIIYFFPAIFVTASICRCHGFGKQLGWLYMALLCIARVVGSSLQIASEISHDSNLRSAVSVVSSVGITALLLALLEIIDRYEAMLPFKHIDRRAWSFIHLTQYAAFILYAVGLGMGRVDLTRAASILVAVVRKLAGDKRLLRFAVASIPFLTVRVAYGLSTSFIASDTVFMKGLTHVLATAFLQYLMEFIVTTIFLYAGVFFLHLRKVATSDPGIGLVDCNDLEGNYSQMPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDT3</accession>
    <name>A0A2I2GDT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_382044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706279.1">
        <property type="nucleotide sequence ID" value="XM_024845593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDT3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDT3"/>
    <dbReference type="GeneID" id="36553292"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_382044"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="333" mass="37210" checksum="A44C59D482EA12D9" modified="2018-02-28" version="1">MASITSPSHSKSLTLSTGHTYAYIHHPPTPQHQTTILFLHGFPSSSYDWRHQIAFFASQGYGILAPDLLGYGDTSKPVSLDAYKANAMAAEIIEILDHEGQEKVHAVGHDMGCGLLSRLADYYPERLASCVFLAVPYANPGGRFDLGMVNQMSRQVLGYERFGYLGFFVGEEAAGVLDRFGESFFTLFYPHDPDLWISHVGPTGAMELWLHDDARAPLASYLTEEEKAKHQQIMHGNHRFALNWYRALVGNINAEDELRAGLEPALKMPTLMVSPQPSRLEFPGVEENMRVVAQDLTLKHVSTKGHWLQLEAREEVNGILERFLESVDGAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEQ0</accession>
    <name>A0A2I2GEQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_436390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706670.1">
        <property type="nucleotide sequence ID" value="XM_024849146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEQ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEQ0"/>
    <dbReference type="GeneID" id="36556845"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436390"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="13639" checksum="5029CF98CBA290E0" modified="2018-02-28" version="1">MGYSLIFQRNYTPMATGLDEVLPIGNVGSEHIVDTSASGSPSEDSTPRGTLEILAAKVPPPRISENFMAPVNDTTNKRCQEWTMEYLCHLVKKGIIGADAIPVVQSKRDPPTHGIGLQPVVNRAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFR3</accession>
    <name>A0A2I2GFR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_401150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707026.1">
        <property type="nucleotide sequence ID" value="XM_024846359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFR3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFR3"/>
    <dbReference type="GeneID" id="36554058"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401150"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001856">
        <property type="entry name" value="RAS small monomeric GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="283" mass="31344" checksum="F8C340748E52E106" modified="2018-02-28" version="1">MADAPDRISITICGDGGCGKSSITLRLVRSQWIHEYDPTIEDSYSVTRTIDGLPYFLSITDTAGQEEYRGLWTASNLKSDAFLLVYDITNVSSLGALDDFMELINIEAEQRVEDNQRLLKELGDNAQGLDVGMPPPIKIVAGNKCDLKEGRVIGAREGLEYARKHGCGFMETSAREMVNIEETFALLVRRVVEARRLHYQRGASATHAPQPLGPSVEKNSDVATHEAVNSDPPKVKPPRQSFLGMFKKGEKPLYQEAAPKSSGPEKSLHTPRPSIWRRLCCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG11</accession>
    <name>A0A2I2GG11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_351665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707128.1">
        <property type="nucleotide sequence ID" value="XM_024843884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG11"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG11"/>
    <dbReference type="GeneID" id="36551584"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351665"/>
    <dbReference type="OrthoDB" id="4188028at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="841" mass="90298" checksum="3009F3E27E8A387C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG42</accession>
    <name>A0A2I2GG42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_433740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707160.1">
        <property type="nucleotide sequence ID" value="XM_024848565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG42"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG42"/>
    <dbReference type="GeneID" id="36556264"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433740"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="254" mass="27491" checksum="EA07148C6A3B2843" modified="2018-02-28" version="1">MGRVIRNQRKGRGSIFTAHTRLNKAPAQFRTLDYAERHGYTRGVVKEIIHDPGRGAPLAKVQFRHPYKFKQITETFIANEGMYSGQFIYAGKNAALTVGNVLPLASVPEGTVVTNVEEKSGDRGALGRTSGNYVTVIGHNPEEGKTRVKLPSGAKKVIKNTSRGMVGIVAGGGRTDKPLLKASRAKHKFAVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYAAQGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGK7</accession>
    <name>A0A2I2GGK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_471931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707320.1">
        <property type="nucleotide sequence ID" value="XM_024852888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGK7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGK7"/>
    <dbReference type="GeneID" id="36560586"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471931"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="581" mass="65916" checksum="ED1E6792B57D8A87" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGQ5</accession>
    <name>A0A2I2GGQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_351690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707360.1">
        <property type="nucleotide sequence ID" value="XM_024843885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGQ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGQ5"/>
    <dbReference type="GeneID" id="36551585"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351690"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="715" mass="81242" checksum="59508A715BC57B0F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIM6</accession>
    <name>A0A2I2GIM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_434450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708031.1">
        <property type="nucleotide sequence ID" value="XM_024848718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIM6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIM6"/>
    <dbReference type="GeneID" id="36556417"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434450"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="11"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="353" mass="37988" checksum="B2CA0D28F487D01B" modified="2018-02-28" version="1">MKEALVDLEAAVYPRVSIVDSPIPTPAAGQVVIKVVAASLNPKDYKHKSPGTINQGDDVAGVVHLTGDNVTEFKVGDRVAAFHQMGAPHGAFAEYAVTWAYTTFHIPESVSFEEASTIPLAGLTAALGLYQSLRLTPPWLPETESHPFVVYGGGSAVGAFAVKLAKLSNLHPLIVVAGKSGSQIETLLDRSQGDVVIDYREGDTAVVSKLRTALNGQPLLHAFDAITEFNSYQNLAQIIDPQAGRITTIQPVREDRDKFPPAVDVSFTFVGRVHGPVPEKKDGNVTLGNREFAAVFSRFFGQGLRDGFWSGHPWVAVPRGLEGLEQALGELKDWKSSYSKHVVRIADTPGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIT1</accession>
    <name>A0A2I2GIT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_472683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708094.1">
        <property type="nucleotide sequence ID" value="XM_024852971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIT1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIT1"/>
    <dbReference type="GeneID" id="36560669"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472683"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000058">
        <property type="entry name" value="Fatty acid oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000005">
        <property type="entry name" value="Fatty acid oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124640" checksum="84AFCD4C5EFBFEB1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIV8</accession>
    <name>A0A2I2GIV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD binding Rossmann fold oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_378974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708113.1">
        <property type="nucleotide sequence ID" value="XM_024845470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIV8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIV8"/>
    <dbReference type="GeneID" id="36553169"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378974"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="412" mass="45368" checksum="DEA702E2500BA7AE" modified="2018-02-28" version="1">MAPSVLMVGTGEYTTGYVGGAASGSDKKVGVVGLTMFDLRRRGKVGKLSMVGVSGSKYPGIREHLNKNISQVYNGLDTSFDSYPADNQTDPDAYKAAIDALEPGSAITIFTPDPTHFPIALYAIQRKIHVLITKPATQLLSDHLTLLEEARKNGVFVFIEHHKRFDPAYSDARAKAQNLGDFNYFYSYMSQPKSQLETFKAWAGRDSDISYYLNSHHIDINESMVPDYTPVKVTASASKGTAVELGCVPETEDTITLLVDWRHKADLSKNATGVYTASWTAPQKAGVHSNQYFHYMGSKGEVRINQAKRGYDVTGDESGLSWLNPFYMRYAPDDEGNFAGQTGYGYISFEKFIDAVTAVNEGRVTLDQLDARPLPTLKNTIATTAILQAGRVSLDEKRSVEITSENGHWALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJA2</accession>
    <name>A0A2I2GJA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1765-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_444825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708258.1">
        <property type="nucleotide sequence ID" value="XM_024850660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJA2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJA2"/>
    <dbReference type="GeneID" id="36558359"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444825"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="954"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1156" mass="128106" checksum="2FE8BEA2F87290B2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJQ0</accession>
    <name>A0A2I2GJQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Copper resistance-associated P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_454281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708410.1">
        <property type="nucleotide sequence ID" value="XM_024851417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJQ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJQ0"/>
    <dbReference type="GeneID" id="36559116"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454281"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="736"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1110"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1157"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="145"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="231"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB53108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1195" mass="128778" checksum="6D75AA12DE2BBE6F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK72</accession>
    <name>A0A2I2GK72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_445063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708573.1">
        <property type="nucleotide sequence ID" value="XM_024850675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK72"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK72"/>
    <dbReference type="GeneID" id="36558374"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445063"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36270" checksum="CF20DE1A9D0F687D" modified="2018-02-28" version="1">MYDKDITESNHSHSGDDNSHEASSQRDSEKGLLTGDFTQRAKEYDPENHKPQRWSVRSCAWTVWFTCLNIAVLCGSVLFLMSPLSSQACLRHLSDQDKWKASSAYAPILERFDIPRQELITNGSLYDGSPPSIMRMAQGDEADDEWNRISSHVFPILISADEIRKLGKDPSLAVRVPDEFGYGPDAYIAQTEVFHLLHCLDMLRKEISYEHYYFPMFGNNPDAQHTAHITHCVDILAQFIKCQSPADVILFNWVGGWDQPFPDFFNKHVCRDYEALLAYVNENSLPKEVFQQMKVPPADYPVQPDPSIAPFVPTGVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL07</accession>
    <name>A0A2I2GL07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_454567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708860.1">
        <property type="nucleotide sequence ID" value="XM_024851449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL07"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL07"/>
    <dbReference type="GeneID" id="36559148"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454567"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="691" mass="78311" checksum="387971C5144831AC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL73</accession>
    <name>A0A2I2GL73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_431444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708922.1">
        <property type="nucleotide sequence ID" value="XM_024848037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL73"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL73"/>
    <dbReference type="GeneID" id="36555736"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431444"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="291"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1138" mass="126716" checksum="FF83D5999AC09237" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GME3</accession>
    <name>A0A2I2GME3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saponin hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_442213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709349.1">
        <property type="nucleotide sequence ID" value="XM_024850448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GME3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GME3"/>
    <dbReference type="GeneID" id="36558147"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442213"/>
    <dbReference type="OrthoDB" id="10265322at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="66598" checksum="25D0C9D07903EEDF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMH4</accession>
    <name>A0A2I2GMH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_460325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709384.1">
        <property type="nucleotide sequence ID" value="XM_024851931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMH4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMH4"/>
    <dbReference type="GeneID" id="36559629"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460325"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="598" mass="66852" checksum="33BF8341E2C9E43F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMJ0</accession>
    <name>A0A2I2GMJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_469569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709404.1">
        <property type="nucleotide sequence ID" value="XM_024852648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMJ0"/>
    <dbReference type="GeneID" id="36560346"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469569"/>
    <dbReference type="OrthoDB" id="4500340at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="19050" checksum="1A8FA92842045959" modified="2018-02-28" version="1">MQIRYFAADETQPYLNASVDDQFHFNILTKSDLEALGDIDVQSRERQKIFDHQSGSTYVVGDVVKLRIFRDGDIRSHDRDFYVLLSDHDHLESGLHAILTPFCFPSENEYSNGDQVAVIRVKPPTEEEKKKQEENEKRRREAAEERDRKRREQEKAQNQPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMJ4</accession>
    <name>A0A2I2GMJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_397162</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709413.1">
        <property type="nucleotide sequence ID" value="XM_024846161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMJ4"/>
    <dbReference type="GeneID" id="36553860"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397162"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="42"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB54111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="407" mass="47338" checksum="5CF02A38E6FD1873" modified="2018-02-28" version="1">MWWPFSRTSTTNNPPPRGLPASWYRSEAMYQLERRAIFSKSWILLTHSSRFTKPGDFLSFTVANFAFFVIRDRDGSLNAFHNICRHRAYPVVQSSCGTASILACKYHGWSYGLKGNLSKAPRFETVPDFDKTKHSLFPVHVHTDKSGFVWVNLQAGETPDVDWDEEFDKIDEQPRMQDFDFTGDYAFDHFWDMEVDANWKGLVENYNECYHCATSHPLIRGVSDLPKYRVEPKAGYMEHHIYNKETSDAQFKRAITYFYPTTSVTVTDKFFYIQRMIPVTATTSRVENEVYRHRNATDEEFDNINAFYRQVLEEDRELCVGAQENLSAGVFTNGELHPSKEMGPIHFQDRVREAVMEHRRKEEQNGGQTIWPATPSAPLMTQKLQEEESFCSKLEADSCMERPELSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMK0</accession>
    <name>A0A2I2GMK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709423.1">
        <property type="nucleotide sequence ID" value="XM_024848120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMK0"/>
    <dbReference type="GeneID" id="36555819"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431781"/>
    <dbReference type="OrthoDB" id="4496655at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="231" mass="25513" checksum="BFE8262B1C870C3A" modified="2018-02-28" version="1">MAFTLSSIGTNLYTAFAVFLLTSWILTALGFTALNVLNTSSSFIESFASISLLTFLLARLIVLTTTQKDDAPNTIAHTITTAHRRSQKAALLLFTFTCTWLYELLMKAVMSFFMVVLGFAVTAIIYNDPEGKDWTVTDNGRTTQSQQEDSPTTALAEIDEFKTRAGVDFDPTAIFKWIPPQTLVYLVVLVWLNFATLGVYLMRYAWRALKSALGSSTASTFPVAAVQGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMM0</accession>
    <name>A0A2I2GMM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_372768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709401.1">
        <property type="nucleotide sequence ID" value="XM_024845213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMM0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMM0"/>
    <dbReference type="GeneID" id="36552913"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_372768"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF9">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="1">
        <location>
            <begin position="130"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="351" mass="37994" checksum="05BBD5CCCD44026E" modified="2018-02-28" version="1" fragment="single">MHLSDIGKLVGVAMAGLSIAHPGAHEPSLYTDLSKRDFLHHARRSLDKCSDQLERRGINARAEARRAAIVDMYRKRSLNARDTDKVVNTSHHSSLHVTANTRESELFAKNPVCLLAPEGEIGPFWVKGELIRSDIGDGEPGIPIILDGQFIDINTCEPIQDLYWDVWNCNSTGVYSGVDSTMNGNGNDHANLNKTFLRGIQKTDEEGVAQFNTIFPGHYDGRATHVHVVAHVGASVLPNNTLTGGHVAHIGQLFFDQDLISVVEATYPYNTNTVDITQNADDHVVQVETEDSNSDPFFEYAYLGDSIEDGLLGWITLGVNVTANHDSAASYAASLTPSGGVSNDASSGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMT8</accession>
    <name>A0A2I2GMT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_420969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709510.1">
        <property type="nucleotide sequence ID" value="XM_024847335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMT8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMT8"/>
    <dbReference type="ESTHER" id="9euro-a0a2i2gmt8">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="GeneID" id="36555034"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420969"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="89"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="297" mass="32871" checksum="79D7971C4211CEAF" modified="2018-02-28" version="1">MANSAVHFLRLPVLASSGLAVVASGLLYFKQNELIYPRNVPVDARTNVPKPRQFGISDYEDLQIPTPDGESLHALFIRPSKKRTTRNITVLMFHGNAGNIGHRVPIARVLQDVLGCNVLMLEYRGYGLSTGVPDEAGLKIDAQTGLDYIRQRAETRDSDILVYGQSLGGAVSINLVAENQDSGDIKGLILENTFLSIRKLIPTVFPPARYLARFCHQYWTSEEVLPKITKVPILFLSGLKDEIVPPSNMTQLFAICTASRKVWRTLPNGGHNDSVAEPGYFEHIHSFVMEEVVGQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN43</accession>
    <name>A0A2I2GN43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_12512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709588.1">
        <property type="nucleotide sequence ID" value="XM_024842381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN43"/>
    <dbReference type="GeneID" id="36550076"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_12512"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="178" mass="19633" checksum="FAACCADB91A2E0BC" modified="2018-02-28" version="1">MTVPLPQYRRSDPFSDRKLAGRVQSRLEPGHGWYRPHPPATSSAFPRVNSNISLSPSLSLSLSLSLSLSLSLSLDLSCSFALLLSLSWVRSALLLGSWTHRLIHASQPTDNSLFSIILLHLDFDTLLCYPLIICQTVGVASPLFSHPFLQQPLSPGFSCSLTKHLHSAKHPSRIHQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP57</accession>
    <name>A0A2I2GP57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hxB</name>
        <name evidence="7" type="ORF">P170DRAFT_452372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP57"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP57"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452372"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="6">
        <location>
            <begin position="654"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="837" mass="92580" checksum="976AEFEF71E4C415" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP73</accession>
    <name>A0A2I2GP73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_432315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709983.1">
        <property type="nucleotide sequence ID" value="XM_024848235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP73"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP73"/>
    <dbReference type="GeneID" id="36555934"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432315"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000026">
        <property type="entry name" value="GTPase activating protein for Arf, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF7">
        <property type="entry name" value="ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="686" mass="73535" checksum="C8C1A8296B84C0D1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPB9</accession>
    <name>A0A2I2GPB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_483423</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710023.1">
        <property type="nucleotide sequence ID" value="XM_024853895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPB9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPB9"/>
    <dbReference type="GeneID" id="36561593"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_483423"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF14">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB54721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="35759" checksum="6743D2F118BC53E4" modified="2018-02-28" version="1">MSVQTPTIKLNNGTEMPIVGFGLWKLDTKTCADQVYSAIKSGYRLLDGACIYENESQCGDGVARAINEGIVKREDLFIVSKLWNNFHDADKVEPITRRQLQDWKIDYFDLFLMHFPISLEYVDPAVQYPPPDGPEFPPGRASVQETWLAMEKLVSAGLTKGIGISNFNGGLILDLLKYANIRPATLQIEHHPYLTQEQLVNWVQGQGIAITAYSSFGPSSYVELDTEDAKHTPLLFEHPAVVQLAEKYAKTPAQIVLRWATQRGIAVIPKSGNTQRLAQNLSVTDFDLSAEDLKSISAMNRNLRFNDPMKFGEPHPIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ56</accession>
    <name>A0A2I2GQ56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative HMG box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_398821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710306.1">
        <property type="nucleotide sequence ID" value="XM_024846249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ56"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ56"/>
    <dbReference type="GeneID" id="36553948"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398821"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF320">
        <property type="entry name" value="BOX TRANSCRIPTIONAL REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="136"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="136"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="687" mass="76189" checksum="414B55142709845E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR44</accession>
    <name>A0A2I2GR44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_461248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710657.1">
        <property type="nucleotide sequence ID" value="XM_024852018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR44"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR44"/>
    <dbReference type="GeneID" id="36559716"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461248"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000013">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="129"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="474" mass="52660" checksum="E2C935414833E18B" modified="2018-02-28" version="1">MKAPRRSMRTLSSLPASYANVRYVSRTSNAKSSLAAATSATNAWQQMPAKTGSASPLAKLPLSSVLRSLMILSVSSSKLLLKPCIYTLSMLAHPKTPALDVAKNPFLNMLVKHTIYKQFNAGENKLEVQRSIEDIKQLGYRGVLLGYAREVLVGESDADPLDEKAAREEIQMWLDGTLQTVDMAQEGDFVALKFTGMGIQALQLLQQQAMPSSFMDASIQRVCDLAVSRNVRLLVDAEEQAVQPGIEHWTMKYQKYCNSQTPGRAIFYNTYQAYLCSTPATIARDLETARQEGYTLGVKLVRGAYLKTEPRHLIWATKEETDECYDGVVEALLTRRYNSMLQSASKEHQTELPSVNVIVATHNRDSVRKAHALRMQQAIQGDSQGVDLSYAQLQGMADEVSCELLQGFQGPESSQPSSLEVPNVYKLLTWGSVKECMGFLLRRAVENTEAVGRTKQSQEAMFGELKRRVFGPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRJ4</accession>
    <name>A0A2I2GRJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_399635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710776.1">
        <property type="nucleotide sequence ID" value="XM_024846288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRJ4"/>
    <dbReference type="GeneID" id="36553987"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399635"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="654" mass="73716" checksum="D4478C8432645406" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRY7</accession>
    <name>A0A2I2GRY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cell wall biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_399898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710937.1">
        <property type="nucleotide sequence ID" value="XM_024846299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRY7"/>
    <dbReference type="GeneID" id="36553998"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399898"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="112" mass="12558" checksum="257E2C5C580C5EA1" modified="2018-02-28" version="1">MESTTQGLETPTHCIADFSLVPIGTHDTSFAQEIAEIQRLLQRCDIKHQMTCTGTAVEGPWDQVLQVIGHAHQLVHKRGVARIQTDLRVTTRTDKDQPMENEILSVERILTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS43</accession>
    <name>A0A2I2GS43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_443422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710994.1">
        <property type="nucleotide sequence ID" value="XM_024850543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS43"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS43"/>
    <dbReference type="GeneID" id="36558242"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443422"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25990" checksum="6C5053C220C175B4" modified="2018-02-28" version="1">MAVKSLAIISEAVARRFAKEYSVALLSNSPQPFPHMIEDINNFGGNTAFRKIASHFPGALLAAAAYNPPERFREKRHTKHDEYNLMEDFHKQTYSNHSSGEGVFNFARHTLPLLRDAKRDLQYPPTLLITGSAASVTGFPRLASYSAGKFAIRGLAHSLAREDAPQGIHVAHIIAHGRLEKSEFAIERYTHPIGNARKVADTYWDLHVEKDPNEFTLEYDLRDKESSKLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSD6</accession>
    <name>A0A2I2GSD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_325524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711082.1">
        <property type="nucleotide sequence ID" value="XM_024843341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSD6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSD6"/>
    <dbReference type="GeneID" id="36551041"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_325524"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="167" mass="18519" checksum="9390F09B7A0A39B1" modified="2018-02-28" version="1" fragment="single">PPATQEPQHQHQPSPEPSNQSKETLEAKTAFTATLRSVGENHETQIRDRARTLHANASALSRQETELQRTTEALRKQNDGWAKVADQARDGLKEIGDVQNWAELIERDLLVVEETVRLAEEKENAMQEEGREDEGGERGGNGDADGDGKDVDGGKKGKGKGKGWLWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSL5</accession>
    <name>A0A2I2GSL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711158.1">
        <property type="nucleotide sequence ID" value="XM_024848461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSL5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSL5"/>
    <dbReference type="GeneID" id="36556160"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433325"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="358" mass="38417" checksum="0D204FCE2EBD3F06" modified="2018-02-28" version="1">MEDPTPPKHYVSAPSAKTFIQSILTGNGVSADNAAIITDCLIQADLRGVDTHGTNRIPSYMERIRQGVLDPAATPTLTQVTPVVAQVDAHNGFGFVGAQKGMARAIEMAQEFGIGLVSVKHSNHFGMSAWVVQQALDAGMMSLVFTNSSPALPVWGGREKLMGVSPIACGAPAGKQRPFILDMAPSVAARGKIYKAARRGEKIPGDWALDGEGKPTEDPNRALEGVMLPMGGPKGSALSVMMDVFSGVLSGSAFAGHVTNPYDPSKPADVGHFLVAIKPDLFMGLEEFKERMDYLYQRVVGSEKMAGVDRIYYPGEIEQIMHEERLKTGIPYVQAEVDALNKEADRVGVDHVVVSEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQ49</accession>
    <name>A0A2I2FQ49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_371664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000035">
        <property type="protein sequence ID" value="PLB42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698041.1">
        <property type="nucleotide sequence ID" value="XM_024845176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQ49"/>
    <dbReference type="GeneID" id="36552876"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371664"/>
    <dbReference type="OrthoDB" id="4231495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="124" mass="13274" checksum="A00300AEFC2ABBFD" modified="2018-02-28" version="1">MWILHGNVTERGDVGGGPGKSYLFFLTAYHPEIGLVRCAPTTLENPREGIVFTPGRTHNRSRSPRIGSKGRARWALGGTPRSRGALAGQPAGAPQHRAGDALGRLRPSGGRLTTNLELVRTRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQP1</accession>
    <name>A0A2I2FQP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_514685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514685"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="244" mass="26613" checksum="9070C029A6137758" modified="2018-02-28" version="1" fragment="single">LLPQAPDRPRAFCPGHHTPRTVLPRDLGRSHHVITPTRPPKAPSRANWSASGPLSRTSPLPARHHPPPCILPKPPPRQLVWRWATPGPFDQAPDHPRTAPVPFRSGAHPPPDLLPQAPCPPGGAPPSPATPAPGPHEGAWAGEGSRGKNPGCRLPRRHPQVAPRWPTGPAPGQTAKPPVRPGEWVPLRPTGSGFRQRRRTPKTPRRGSRKPEEGTVVSATRLLDRVHDPLGHFSRLQRIHPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQV9</accession>
    <name>A0A2I2FQV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_370553</name>
        <name evidence="19" type="ORF">P170DRAFT_370606</name>
        <name evidence="20" type="ORF">P170DRAFT_370645</name>
        <name evidence="17" type="ORF">P170DRAFT_370660</name>
        <name evidence="16" type="ORF">P170DRAFT_370713</name>
        <name evidence="14" type="ORF">P170DRAFT_370792</name>
        <name evidence="15" type="ORF">P170DRAFT_370797</name>
        <name evidence="13" type="ORF">P170DRAFT_370811</name>
        <name evidence="12" type="ORF">P170DRAFT_370863</name>
        <name evidence="11" type="ORF">P170DRAFT_370888</name>
        <name evidence="10" type="ORF">P170DRAFT_370987</name>
        <name evidence="9" type="ORF">P170DRAFT_371032</name>
        <name evidence="8" type="ORF">P170DRAFT_371086</name>
        <name evidence="7" type="ORF">P170DRAFT_371255</name>
        <name evidence="6" type="ORF">P170DRAFT_371343</name>
        <name evidence="5" type="ORF">P170DRAFT_371362</name>
        <name evidence="4" type="ORF">P170DRAFT_371449</name>
        <name evidence="3" type="ORF">P170DRAFT_371516</name>
        <name evidence="2" type="ORF">P170DRAFT_371591</name>
        <name evidence="1" type="ORF">P170DRAFT_371615</name>
    </gene>
    <organism evidence="12 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000033">
        <property type="protein sequence ID" value="PLB42749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000032">
        <property type="protein sequence ID" value="PLB42761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000027">
        <property type="protein sequence ID" value="PLB42792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000025">
        <property type="protein sequence ID" value="PLB42817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000024">
        <property type="protein sequence ID" value="PLB42822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000023">
        <property type="protein sequence ID" value="PLB42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000022">
        <property type="protein sequence ID" value="PLB42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000019">
        <property type="protein sequence ID" value="PLB42909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000018">
        <property type="protein sequence ID" value="PLB42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB43006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB43017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370553"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370606"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370645"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370660"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370713"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370792"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370797"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370811"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370863"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370888"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370987"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371032"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371086"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371255"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371343"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371362"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371449"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371516"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371591"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371615"/>
    <dbReference type="OrthoDB" id="4384180at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB42817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB42822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB42845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB42909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB42933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB42953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB42975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB42986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB43006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB43017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB43029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB43038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB43056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB43067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB43079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="78" mass="8742" checksum="4E9DBA8B74152DF6" modified="2018-02-28" version="1" fragment="single">RLTHVQLLFTWNLSPLQSSKFSFEYLLLPPRSALGAVRPGITPKASSRTPTPAYSSGHRFYPDGEVWVTRLSAIHFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRC4</accession>
    <name>A0A2I2FRC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_441648</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698490.1">
        <property type="nucleotide sequence ID" value="XM_024850365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRC4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRC4"/>
    <dbReference type="GeneID" id="36558064"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441648"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB43188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="520" mass="57080" checksum="1F3F74E598B99A36" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRX5</accession>
    <name>A0A2I2FRX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_481320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698675.1">
        <property type="nucleotide sequence ID" value="XM_024853858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRX5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRX5"/>
    <dbReference type="GeneID" id="36561556"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_481320"/>
    <dbReference type="OrthoDB" id="4497764at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="513" mass="56962" checksum="59B41E9501E3DA08" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS25</accession>
    <name>A0A2I2FS25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_441810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698725.1">
        <property type="nucleotide sequence ID" value="XM_024850405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS25"/>
    <dbReference type="GeneID" id="36558104"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441810"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000245">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="510" mass="55986" checksum="D7E8225957A09172" modified="2018-02-28" version="1">MAPDAADQSPTGASEKQPASKTNQTSPSTGDAALELLGNGALGGPLDPEASARLVRKIDLYVMPLICIVYFLQYLDKIAVSYASVTGVRESTNLHGNQFNWVSSIFFFGQLALQFPTMRLIQAFPLARYVAFNVTVWGAILACMAACKSFASLMVCRALLGAAEAAVVPAWVVFTSQWYRKEEQAFRVGLWFSMCGFAQMFGGYIAYGVAVHIGGDPSAALRGWQVIFLILGLFTAIIGIIFFFILPDSPVTAWFLSPEEKAMHAERLRGNEQGIGSTVFKKEQVYEAFRDPQTWMYSFWVFAANIPNSIATSFGNILVTGMGYSSTQSLLLVTPLGAYEVVALIGLTYLAMRMEQRLLWCIIGHIPSIVGAILMATTDKAPALVGYYLSGGIPIGWTTILGLTSTNVAGSTKKITVSCIQTVAYTVGNIISPQTFAPSDAPQYLPAKISIVILYFLVTVDLCLIRWMFIRENRKRDQEKAALGDAYVVPENHEFLDLTDRQNREFRYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS82</accession>
    <name>A0A2I2FS82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_369002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698768.1">
        <property type="nucleotide sequence ID" value="XM_024844888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS82"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS82"/>
    <dbReference type="GeneID" id="36552588"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369002"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014126865" evidence="1">
        <location>
            <begin position="23"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="74"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="373" mass="40805" checksum="47A98E4D8A90502C" modified="2018-02-28" version="1">MWSRGVLTGLIALASLARTAVAHNSTSSEVAYQREYLYVGGQYVKNADGDHLFADQMYVEKLIPEGGASKPHPIVFIHGQAQTGTNWLNKPDGGRGWASYFLEQGYECYLLDQTFRGRSPHVPGNGTMKTYSAEKLQQLFTAPKKYMQWPQAALHTQWPGTGVMGDKIFDTYYASTVDFFGEAVGQQITVQRAGAALLDLIGCPVILLSHSQGGIMPWILTEVRPKQVHAIVSLEPSGPPFNGATANASSLAYGLSDIPLTYSPAVTDPKTDFALKKLPSNSTARDECVLQADHPAPRQLVNLQKVPVVVVTTESSYHAPYDWCTVKFLKQAGVSAEHMQLGELGIHGNGHMVFLEKNSDEVAGVIQKWIEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSM6</accession>
    <name>A0A2I2FSM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_165363</name>
        <name evidence="3" type="ORF">P170DRAFT_58306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000030">
        <property type="protein sequence ID" value="PLB42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698074.1">
        <property type="nucleotide sequence ID" value="XM_024842590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSM6"/>
    <dbReference type="GeneID" id="36550287"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_165363"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_58306"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="155" mass="16591" checksum="5410D0826BEDFC18" modified="2018-02-28" version="1">MDGGTPQDYGVLSILAIFDLQHVFPCKKGNEEGISIRGFGVHATNKGSHLIGSHGNWRISSLRLLRLRLLVRHTPSSTPVGCGSSGSSLNNASIILFSSLSPSLHSTQTSSFPQSTVSIPNVAPEKLSGPKLYKAGPLTIARKDGSRRRTTRQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSM7</accession>
    <name>A0A2I2FSM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS peptide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_417885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698950.1">
        <property type="nucleotide sequence ID" value="XM_024847184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSM7"/>
    <dbReference type="GeneID" id="36554883"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_417885"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="602" mass="66941" checksum="FBDD61804261895C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSR8</accession>
    <name>A0A2I2FSR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024850238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSR8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSR8"/>
    <dbReference type="GeneID" id="36557937"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441124"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10189" checksum="BCD35BD6B6357C05" modified="2018-02-28" version="1">MVHKVLFWGGFGIAVRLWQLGIEMRPILAKESLWVYPLFAGVGGSFGYWLQGVESRQLKILAQRREAILEKRRRRDEKVEETGSLAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FST1</accession>
    <name>A0A2I2FST1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_369525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698981.1">
        <property type="nucleotide sequence ID" value="XM_024844912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FST1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FST1"/>
    <dbReference type="GeneID" id="36552612"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369525"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="435"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="823" mass="90563" checksum="CBB47D9FC986227E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT14</accession>
    <name>A0A2I2FT14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein Msh5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_418102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699085.1">
        <property type="nucleotide sequence ID" value="XM_024847196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT14"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT14"/>
    <dbReference type="GeneID" id="36554895"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418102"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000050">
        <property type="entry name" value="DNA mismatch repair protein Msh5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="6">
        <location>
            <begin position="307"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="672"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="948" mass="104915" checksum="56AFC96F50F2335F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT16</accession>
    <name>A0A2I2FT16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_450934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699064.1">
        <property type="nucleotide sequence ID" value="XM_024851158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT16"/>
    <dbReference type="GeneID" id="36558857"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450934"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF8">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="376" mass="39920" checksum="9627EE54F4EFB05A" modified="2018-02-28" version="1">MADLTSARNHIQVATDSNAESLRQLNLGIHGHPETAHEEVHAHDTLTSFLETRGFNVTRHAYGLSTAFEAELGTSGPIVIFCAEYDALPGIGRACGHNLIATSSMAAFLGLANSVKQLEVPGRVRILGTPAEEAHGGKIQLIDAGAFHDPAIVAAIMVHPTAQRSIPEGYQGVAGWESIANALIQVEFHGKGAHAGGDPWNGVSALDAAVSAYNSLAMLRQHIRPDERIHRIIEDGGKSIRGRTAARTDELLARAKACFEAAGVSTGCSVSYTMEPMYKDIVVNDPFCQIYTEEIAALGRKVQLKSDGPTTVSTDMGNVSYAVPSFHGVFGIPTPDGVPPHHAGFAKAAGLEEAHHEAIICGKAMAMLGWRLLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT61</accession>
    <name>A0A2I2FT61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_430827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699108.1">
        <property type="nucleotide sequence ID" value="XM_024847984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT61"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT61"/>
    <dbReference type="GeneID" id="36555683"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430827"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="120" mass="13514" checksum="BD67656785BD3A7C" modified="2018-02-28" version="1">MLGYWASLGRPVYSYIHKGQTIPYISDVAAQELQPLFVTGCLVSVILLNISLVLILKARSAGPKPSVKLLRWKRAGISHTWFHYLAIFLTAAGSVGLVLLARFDRLQYPDLHREFLTLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTA2</accession>
    <name>A0A2I2FTA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_480822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699175.1">
        <property type="nucleotide sequence ID" value="XM_024853814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTA2"/>
    <dbReference type="GeneID" id="36561512"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480822"/>
    <dbReference type="OrthoDB" id="4459037at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="131" mass="14397" checksum="87C61BB5045BF598" modified="2018-02-28" version="1">MTCLVLSSLSYSHPLPHPGSIQPRSPSPANYPGSDDIVSDVLSSLGFTHLAKLNHWKSWQDANVIDDSNSTTPTSTEHGNQNTNTKDVTKEEQSDILNPATDPFGFVSGIFDFLSHRFSEAKNSRDEHTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTZ2</accession>
    <name>A0A2I2FTZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_441522</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699373.1">
        <property type="nucleotide sequence ID" value="XM_024850330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTZ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTZ2"/>
    <dbReference type="GeneID" id="36558029"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441522"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="15">
        <location>
            <begin position="85"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="16">
        <location>
            <begin position="502"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="663"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB44071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="704" mass="76771" checksum="AFE7A21325E9321C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU47</accession>
    <name>A0A2I2FU47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_440511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699467.1">
        <property type="nucleotide sequence ID" value="XM_024850096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU47"/>
    <dbReference type="GeneID" id="36557795"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440511"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="74" mass="7355" checksum="924DACE3785F5B14" modified="2018-02-28" version="1">MIVFLGLGFGPAGIVSGSLAAAFQSWMYGGFTPAGGIFATLTSMAMLGLLVPSVVLLASLVASGVAIAVWLNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUN0</accession>
    <name>A0A2I2FUN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_283466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699634.1">
        <property type="nucleotide sequence ID" value="XM_024843198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUN0"/>
    <dbReference type="GeneID" id="36550897"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_283466"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF8">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G13060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28781" checksum="D511ED7401F13E00" modified="2018-02-28" version="1">MAETKTNDGPRDLEAQPAQSSSLTQRWMQSVDPKHADLICILLCLVTGLCDSSAYNAWSCFLAMQTGNTIFLGLGASGQPGNKPWGWLKSLVSIAAFFIGAFVFSNITRRVGALRRGTLFVSFLAQTILIVIAVALIEADLIPHTSDDMTLTGGPLFLELIPIALLAFQSAGSITSSRSLGYNEIPTVVLTSVYFDVASDPKLAQVPTTNPKRNRRIGGVVALLVGAIVGGWLSKSSGGMQSALWMAAGFKFVIGLGWLVWKAKKTETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVE1</accession>
    <name>A0A2I2FVE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mis12 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_367736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699915.1">
        <property type="nucleotide sequence ID" value="XM_024844820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVE1"/>
    <dbReference type="GeneID" id="36552520"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367736"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB44613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="334" mass="36660" checksum="74C5FFE9D61B436A" modified="2018-02-28" version="1">MNDATNSLLAEHFSYTPLSLIDDVINSINNLIYQAISSLESGLLSTPPERLGFSHANNGSTIPDTDEDGNVVYPEARLEIENGLHQLETLLESTVDKAFDKFEIIVLRNTFRVEDDLLGWIRLNHYRNLDLNPPPNTPTPETIQAQRKKLQETKKLNRSMKEECARNDAIISQLRSILSTVDSTKNAKSAKAEGESEMPAPSGSKELDLSFLTASPAAQQLRVGVAGSNAQHTPLTTNTTFILSQLPALKTMLTQLRPKLTALPKSVDTAKESKADERRDYIESRIRLHLERSGQLAVGSDGNPVVAGRKMSITEAQALEAVTGLLSQGDMKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVT2</accession>
    <name>A0A2I2FVT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA cleavage and polyadenylation specificity factor complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_439989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700040.1">
        <property type="nucleotide sequence ID" value="XM_024849964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVT2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVT2"/>
    <dbReference type="GeneID" id="36557663"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439989"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="704"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="751" mass="83685" checksum="171E6079B88B9396" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW58</accession>
    <name>A0A2I2FW58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_479399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700157.1">
        <property type="nucleotide sequence ID" value="XM_024853672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW58"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW58"/>
    <dbReference type="GeneID" id="36561370"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479399"/>
    <dbReference type="OrthoDB" id="4240053at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM-cenC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="17460" checksum="4F8B39DD1BF1F77B" modified="2018-02-28" version="1">MALSCNVLANPSFETGTLSPWVASAVDVAQISTGTPVLDGDYYLNLETAVGNRGNSISQSIKDLTIGANYTFSVKARSPNYGANYCGVFAYHGSNSTAGSIASEQLFDQEEWVEVRGSYRPTTSRDILHVGAYCTFSGSSYTGHILFDDLFLGKQECEVQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWZ4</accession>
    <name>A0A2I2FWZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_440289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700456.1">
        <property type="nucleotide sequence ID" value="XM_024850042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWZ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWZ4"/>
    <dbReference type="GeneID" id="36557741"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440289"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="70"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB45154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="198" mass="20816" checksum="67B18C47BE51DDB9" modified="2018-02-28" version="1">MTKESTPPPTVESTTTTTHQPPSLPASPIAKRTKPNTNDADSTPAAANMTVPAAAQRLPPLLVKKLTESARAPTRGSAFAAGYDLYSAKQTVIPAKGKAMVDTGISVAVPEGTYGRVAPRSGLAAKHFIDTGAGVIDADYRGEVKVLLFNFSEVDFTINEGDRIAQLVLERIYTPEVMVVEELEESVRGAGGFGSTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX16</accession>
    <name>A0A2I2FX16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exopolysaccharide inner membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_450177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700480.1">
        <property type="nucleotide sequence ID" value="XM_024851105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX16"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX16"/>
    <dbReference type="GeneID" id="36558804"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450177"/>
    <dbReference type="OrthoDB" id="5280547at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alginate lyase" evidence="3">
        <location>
            <begin position="89"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="406" mass="45562" checksum="1CAB37A6104DE5B8" modified="2018-02-28" version="1">MKIERILTGATLFLSVSSQFVHPGALHTRKDIERVRNKVHAQEQPWYRAWQHLESGVLAQTTWTPSPHEVLVRGTNASWKPTPSQNYGDAYRDAHSAYQLTLRWLIGGNTSYADHAATILNSWGTKLRDLNGTEDKYLAAGLYGYQFANAAEILRLYPGWTADSQAEFSDMLKRVFAPYNHAFLEHHNGKTNFYYANWDLCNVASLLAIGIFTDNRTMFDYATHYWQYGLPDSSVVVNGALPYFSIANFTEQGSGKPFMQMQESGRDQGHAMLCMALLGVIGQQAWNQGVDLFATYGNQILNAAEYVAKYNTNHTVPYVPYTSWEGLLDKISAKSRFDVRPGYEAIASHYTRVKNLNASWSIRFRDYVNGNISTDVEGGGGDYGPNSGGYDAFGHGTLMYRIESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXW4</accession>
    <name>A0A2I2FXW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_364633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700728.1">
        <property type="nucleotide sequence ID" value="XM_024844651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXW4"/>
    <dbReference type="GeneID" id="36552351"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364633"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="343" mass="37490" checksum="5D9F37D4F39D27DE" modified="2018-02-28" version="1">MAPVPASLLRALSIPDPDRASLSTAGLGSGFTSTGAIRATVPSPAAEDEEEERRYFVKTSADGKAAEEMFRGEYESLNAIANSVPGFCPRALSWGFLEESNGKSFFLATEFLELGVGGRTGPSLAQRLGRLHSTPAPPDPETGKRRFGFPVPTFCGDTKQPNRYHDSWADFYANERLLVILDTSEARNGRDASLRDLVERTAHKVVPTLLGDGHLGYDKDGNGEGIIPVVVHGDLWSGNADRGRIIASGRKEDEEVGDVVYDPSACYAHSEFDLGIMKMFGGFGSAFFDAYHRIVPKTEPVEEYDDRVLLYQLYHHLNHHAIFGAGYRSGAVSIMQKLVKKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYL7</accession>
    <name>A0A2I2FYL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701031.1">
        <property type="nucleotide sequence ID" value="XM_024849836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYL7"/>
    <dbReference type="GeneID" id="36557535"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439458"/>
    <dbReference type="OrthoDB" id="10596381at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014146259" evidence="1">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="128" mass="12619" checksum="765034BE100464A2" modified="2018-02-28" version="1">MKFGALTSSILCLAATQFVAAETSTSTLTNTITKTLVRVSTVTSADDAASTTVNSHVLPVSVTVPSSSGFVSSAVASTSVRSASSTSATSTASATPSIPLSTGAASISDANMSAALIAGSFALFVGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYX3</accession>
    <name>A0A2I2FYX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_512460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701145.1">
        <property type="nucleotide sequence ID" value="XM_024854993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYX3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYX3"/>
    <dbReference type="GeneID" id="36562699"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512460"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="959" mass="103734" checksum="C97717C7D5941C4A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYX9</accession>
    <name>A0A2I2FYX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701137.1">
        <property type="nucleotide sequence ID" value="XM_024849862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYX9"/>
    <dbReference type="GeneID" id="36557561"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439539"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="87" mass="9173" checksum="5075823A7FCD65E1" modified="2018-02-28" version="1">MGKLSELTSKVTGGSSHGSHGHHGASAGGPKEDYVDKGLDSLETKYGHGKINPHDPKTRATNEKITDAARHKFESATGKHVPSKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ13</accession>
    <name>A0A2I2FZ13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_429045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701170.1">
        <property type="nucleotide sequence ID" value="XM_024847872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ13"/>
    <dbReference type="GeneID" id="36555571"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429045"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014150346" evidence="1">
        <location>
            <begin position="22"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="220" mass="24342" checksum="F5976E1B5B011D24" modified="2018-02-28" version="1">MKSRLSLVLATSSLIWTAAIAGPKIRDCNDAEQKQCDAELCTRNKHDCDEYHSTRVSFCRRARQLCDGPVKTEEKICTLQDMGQPVRYVSTAGVCSIDDSVDLPKYGSGDETISFVVNLVRSSAVSQGHHDDLVQTLRFTCDHLSTHGASGYTEKVRNTEGLIHWGRGKAIYGMTHDRAVFDGLVKTAKQACAQEQRAFGLETIFESEKSKNALDPRSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZJ9</accession>
    <name>A0A2I2FZJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701298.1">
        <property type="nucleotide sequence ID" value="XM_024849897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZJ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZJ9"/>
    <dbReference type="GeneID" id="36557596"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439690"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="481" mass="55638" checksum="5BDA928EFE4BAA64" modified="2018-02-28" version="1">MTTSSLTTLHRAANLQILHIKSNPSTSYERTNLKSESPAIPSRSLFESLSNPTSSPTSLPTISECAVHLELLQVFNSLKLRVLACNELDDTFGIKPDKRTVYRRRWSNVQRRHVIVPHKLRDLGFARRRLEKWPHYLGLAVTRFKVWVKMVEDGVLESCDGELMILPPLDVLMVWHAFLLNPSDFDAYCDKDKLDLVRKMHFPWKLIHASIDPHEWKYHLPEHHTAKLQSTNLEPDLLETLIQTAKSNTEVSSLLSRFSCTKRGILETFNIIRKYNKDKPPLPRPQSFLENIHSSFLQSQTQENKSLIDQIQRQVSFVEKMDAQLWIRSPAVKGTLGRGIERYEKFLQLLKLYPKKSLVPTLDVDLVWHTHQCSAGRYREAMLERVGRFVNHDDRVGKGVVRNGMQYTAEVFGLRFGQKYEVCLCWDCEAIVDAVEGMQADENEGDVHEFVKNVAEKVLFHREVEVARRMGKMVPVRRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZK3</accession>
    <name>A0A2I2FZK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromatin remodeling factor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_439756</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701365.1">
        <property type="nucleotide sequence ID" value="XM_024849912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZK3"/>
    <dbReference type="GeneID" id="36557611"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439756"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="114"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="387"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="583"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="689" mass="74835" checksum="41315CCA95D0A252" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G029</accession>
    <name>A0A2I2G029_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_415185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701554.1">
        <property type="nucleotide sequence ID" value="XM_024847050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G029"/>
    <dbReference type="STRING" id="1392250.A0A2I2G029"/>
    <dbReference type="GeneID" id="36554749"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415185"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="340" mass="37637" checksum="AD503129F2AF6EC0" modified="2018-02-28" version="1">MSLPHLQPTIPLGSWILVTGANGFIASHIINLLLSSGYRVRGTVREPKPWLDEFFADRHGQDKYQSVVVPGLEVDGALDEYLGDVRGVLHVASDISYNPDPQVVIPKVLAATLNTLKAAAKAHGVKRVVLTSSVVAAFPNSVDGTNSILDTWNDAAVKAAWDPNTPDAIKSAVTYAASKVVAEQAAWKWVEENKPRFQLNTILTNFNFGSTYLPQLRRSSMRLTQNLLQGDDLVMKLIPRQWRVDVDDTARLHAIAVLHPGVVSERVFAASEPFSWARVVEILRRLRPQNKSIPDAPEEAEKIFYVVPSQRAEDLIKEFYGRPGWTTLEESLEAGIEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0J4</accession>
    <name>A0A2I2G0J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_448304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701700.1">
        <property type="nucleotide sequence ID" value="XM_024850955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0J4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0J4"/>
    <dbReference type="GeneID" id="36558654"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448304"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="833" mass="93495" checksum="822D411FEDD0090C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Z6</accession>
    <name>A0A2I2G0Z6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_457135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701840.1">
        <property type="nucleotide sequence ID" value="XM_024851689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Z6"/>
    <dbReference type="GeneID" id="36559388"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457135"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="460" mass="51390" checksum="FCDBB9787B6B5E30" modified="2018-02-28" version="1">MWTFRTPESKLLFKIDFFILSFCCLTYFFNYLDRSNLSNAYVSGMKEELAFHGNQLNLINTIFTVGYILGQVPSNLALTYFRPRIFFPSMILLWGGLTMITAAVHSPQGIMAIRFFLGLAEASTFSGTHYILGSWYTERELGKRSGIFTASGLAGTMFGGFIQTGIHSSLDGARGLSGWRWLFIIDGLITLPIAIYGLFLFPDTPTTTTAPYLNPTERHLAITRLPSTNSHTSRLNLPFLKTLFSTWYWWFFVILWIIAGETESFSSNSLLALYMKSHPTKSYSVSQLNTYPTGVPAVGILSTLFWATLTDYLNGKRYLVGYFIGVTGCVTSGLILARFNDTATVFGAYYWAGAVYACQATFFAWCNDAMRGVDARQRSVVIASMNMGNNAVNAWWSILFYGAEMAPRFTRGMWAMIGCSVALVGWTAGIVWMSGREERRRGTRRMRGKAVGSGKSRCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1C9</accession>
    <name>A0A2I2G1C9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">NADH-cytochrome b5 reductase 2</fullName>
            <ecNumber evidence="5">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P170DRAFT_362078</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701983.1">
        <property type="nucleotide sequence ID" value="XM_024844508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1C9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1C9"/>
    <dbReference type="GeneID" id="36552208"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362078"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0274">FAD</keyword>
    <keyword evidence="6 21" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 23" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB46681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="429" mass="48410" checksum="C17DDD9FA074035F" modified="2018-02-28" version="1" fragment="single">LGRLTEYQVIGRHLPTEANPTPKLYRMRIFAPNTVVAKSRFWYFLTQLRKVKKANGEIVSLNVINEKRPLKVKNFGIWIRYDSRSGTHNMYKEFREMSRTEAVEALYQDMAARHRARFGSIHGFRKYSTEAPKAKSSLAPIYAAVGITGLGVGLYRYNSSAATAEAPIDRPKVFTGGDQGWVDLKLSEIEILSHNTKRLRFEFEDKEAVSGLQIASALLAKFNKPGEKAVIRPYTPTSDEEQPGFLDLVVKVYPNGPMSEHLHSMNVDQRLSLKGPLPKYPWEANKHNHICLIAGGTGITPMYQLARQIFKNPEDKTKVTLVFGNVTEDDILLKKELQDLENTYPQRFKAFYVLDKPPKGWTGGEGFITKELLKTVLPEPKEDNIKLFVCGPPGLYKAISGNKVSPKDQGELTGVLAELGYNKDQVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1K9</accession>
    <name>A0A2I2G1K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_387631</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702048.1">
        <property type="nucleotide sequence ID" value="XM_024845815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1K9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1K9"/>
    <dbReference type="GeneID" id="36553514"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_387631"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000247">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="18">
        <location>
            <begin position="85"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="19">
        <location>
            <begin position="520"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115955" checksum="B221896D9728E884" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2D5</accession>
    <name>A0A2I2G2D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_477891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702331.1">
        <property type="nucleotide sequence ID" value="XM_024853511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2D5"/>
    <dbReference type="GeneID" id="36561209"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477891"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="516" mass="57838" checksum="A119A64D833DA164" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2V5</accession>
    <name>A0A2I2G2V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_448867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702510.1">
        <property type="nucleotide sequence ID" value="XM_024850999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2V5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2V5"/>
    <dbReference type="GeneID" id="36558698"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448867"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="17"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="299" mass="33213" checksum="A023C3736AA597E6" modified="2018-02-28" version="1">MTSSAVLNSRKTIHTAACLIIGDEVLGGKTIDTNSAFLAKYCFSLGIQLKRVEVIADDESEIIEAVRRMSNNYDFVVTSGGIGPTHDDITYESIAKAFGLGLKLHQKAFERMKKLSKPHPMQPQFDWDTPSPNLTAKLRMVEIPHDSTLPEEQQAVFVAEDMWVPIAIVNGNVHILPGVPRLFERLLEHLKPSLLPRLTNPEGKGIYRYLISTPLPESTVAPYLTDLATRTAARGIKVGSYPRWGKKRNTVTLVGTDKDFMDSLVAEVEQNVQGKQVAQEDELDPPSDTEEGKPKEYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G318</accession>
    <name>A0A2I2G318_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_438960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702571.1">
        <property type="nucleotide sequence ID" value="XM_024849729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G318"/>
    <dbReference type="STRING" id="1392250.A0A2I2G318"/>
    <dbReference type="GeneID" id="36557428"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438960"/>
    <dbReference type="OrthoDB" id="5397682at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="75198" checksum="4344870490856868" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G323</accession>
    <name>A0A2I2G323_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">P170DRAFT_413077</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702578.1">
        <property type="nucleotide sequence ID" value="XM_024846955.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G323"/>
    <dbReference type="GeneID" id="36554654"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413077"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000026">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001669">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001988">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 26" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="120"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="24">
        <location>
            <begin position="442"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="25">
        <location>
            <begin position="638"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="22">
        <location>
            <begin position="887"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="21">
        <location>
            <begin position="1038"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="21">
        <location>
            <begin position="1249"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="20">
        <location>
            <begin position="1431"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PLB47276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1532" mass="172898" checksum="A5803ACC236523F9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3T1</accession>
    <name>A0A2I2G3T1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DBR1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_409685</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702844.1">
        <property type="nucleotide sequence ID" value="XM_024846799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3T1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3T1"/>
    <dbReference type="GeneID" id="36554498"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409685"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="526"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="297"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="688"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB47542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="730" mass="81201" checksum="6D5E8089F424631F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4J6</accession>
    <name>A0A2I2G4J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_410134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703107.1">
        <property type="nucleotide sequence ID" value="XM_024846835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4J6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4J6"/>
    <dbReference type="GeneID" id="36554534"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410134"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08286">
        <property type="entry name" value="FDH_like_ADH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="13"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="358" mass="37892" checksum="320E8D9F2172F16E" modified="2018-02-28" version="1">MDTLQMKALVYKGKDKFGVEDRPIPLLHSASDAIVRMRHTTICGTDLHILKGDVPAVKPNRVIGHEGVGTLIGKGSAVTGLHIGDTVLISSISACGVCKSCRKGLSAHCMDGGWMLGNKIDGTHAEYVRVPHATTSLYKLPANINPAAAVALSDALPTGMECGAMSASVQPGHLVAIVGAGPVGLAALLSAKLYTPAKVVVIDKDETRLDHARRIGVDHAINPDTPGLMKILNEITEGSGFDSVIEAVGIPSTFELCQQLVAPGGTIANVGVHGRKVDLQLDQLWDRNISIKTQLVNSHSIPTLLKLSRAGLLNPDSIVTHSFPFSDITGAYASFQNAAELGTLKVKIDFEQHEPHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4X9</accession>
    <name>A0A2I2G4X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_410331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703237.1">
        <property type="nucleotide sequence ID" value="XM_024846843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4X9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4X9"/>
    <dbReference type="GeneID" id="36554542"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410331"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="653" mass="74153" checksum="4BC0D9BBD9F7F55F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5D5</accession>
    <name>A0A2I2G5D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703391.1">
        <property type="nucleotide sequence ID" value="XM_024849450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5D5"/>
    <dbReference type="GeneID" id="36557149"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437801"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014189390" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10235" checksum="CFC906349F91144D" modified="2018-02-28" version="1">MLHQVCITLAWLSLLLSLSPPWLPTRPGHGCLSVSVCQPPFLHSNRKNSFQRLMLKTLPPSLSSTPVLVSATLYATLLCMSRCMDRRHSSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5J4</accession>
    <name>A0A2I2G5J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703449.1">
        <property type="nucleotide sequence ID" value="XM_024853379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5J4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5J4"/>
    <dbReference type="GeneID" id="36561077"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476790"/>
    <dbReference type="OrthoDB" id="4147798at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="123" mass="14141" checksum="EC04729B8B773632" modified="2018-02-28" version="1">MGQRHNRRRTRPRSRNRSINIIPVEPAPRPVTSDPAVSRRTSAACDSRDAIAIHPAPTWHNGYMTWQKRERTPRFESPRLEAEQYRLFGGEPGDDVGLCYRMLEYFDGLDYINTSQCLSPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6B4</accession>
    <name>A0A2I2G6B4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_326501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703705.1">
        <property type="nucleotide sequence ID" value="XM_024843345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6B4"/>
    <dbReference type="GeneID" id="36551045"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_326501"/>
    <dbReference type="OrthoDB" id="72726at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="271" mass="31057" checksum="2536D0D8D765762D" modified="2018-02-28" version="1" fragment="single">LLLLPAELRLQIYNHFFSSTPFTYGKLNQMAPASNHLAILRSCRLINREIDDSWLGQVLFAFENVTDLLNQLSPAPRRMIEQIRRVRVGSSPLTQSIGDGQETTYKLPWALDLIPGLYLDTLTVINTDGPELAYENVNYLIRFGSGWRELHFITGNSEMLAFPRRSIEHNETTQFQWRDPQPSTWIRDLAFRDHVHSDAFVKIYRSTQSNAPGSVMDPNSREVFEQKPPSPENSEFFGIDKDAQLMHPDEIGKELLVIVRRGKDVDISADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6Z2</accession>
    <name>A0A2I2G6Z2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_407311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703942.1">
        <property type="nucleotide sequence ID" value="XM_024846675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6Z2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6Z2"/>
    <dbReference type="GeneID" id="36554374"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407311"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="175"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="294" mass="32423" checksum="C0D1E61AEF7CB3C4" modified="2018-02-28" version="1">MFSSKLITPQDFHEIHSQSHDDSQRIIPVAAGRTAHIPFFNASHIPGSIFFNMDIIRNPDTPYPLMVPTPATFSREMSKLGLRPSDVVVVYDAAEIGTYNAPRVAWMFRIFGHKHVHVLNNFRLYKELGLPVETGDVVGHTLPRESGEAETYPCAQIDQEKVISYSDLCDLLAQADQTYQILDTRTNALFTGEDGYSDPSIQRGHIPGSVNIPLSTVLNENGAIKTPSELRALFEQSGLSEKPVILSCNSGVTAATVEVALEESGYAMPKRLYDGSWMEWGKVSSPASIARGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G723</accession>
    <name>A0A2I2G723_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703973.1">
        <property type="nucleotide sequence ID" value="XM_024853211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G723"/>
    <dbReference type="GeneID" id="36560909"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475024"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="102" mass="11346" checksum="56F93C91A4DD2E32" modified="2018-02-28" version="1">MPSSRASSDRTGSIGSHEAYKKSSLSSKADPNQALTEAQPMANVGTSDMFSLRSMQHRDAEGKIITEPDLTNPTRPRFERPLDTIKNFEAAIERRRKEHAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7B4</accession>
    <name>A0A2I2G7B4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pfs, NACHT and ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_383075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704076.1">
        <property type="nucleotide sequence ID" value="XM_024845630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7B4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7B4"/>
    <dbReference type="GeneID" id="36553329"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383075"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="448"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="908"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="944"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="974"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="999" mass="111782" checksum="68D8B705A1F8E354" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7D5</accession>
    <name>A0A2I2G7D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_464398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704070.1">
        <property type="nucleotide sequence ID" value="XM_024852242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7D5"/>
    <dbReference type="GeneID" id="36559940"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464398"/>
    <dbReference type="OrthoDB" id="4510608at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014117081" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="157"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="231" mass="26172" checksum="020E001B2357884F" modified="2018-02-28" version="1" fragment="single">MNYSTCRRLLSSWVIILLVHCVPGSSLKIRGLQLFNDETGIFSGPLGFPRNFSSEWINAESYSFIDTEPMSFFCSTSQRLPYQQTSWPRLKATPGSTICPHYALDTLSTRDRVDRGVISWYGSSYTNLTDLKSLSDVINIPEAGTGQELAMHSYPSLVHSACPTPFRIPKDLKISSIYTIYWLWNTTKLMETGFQIYTTCIDIEITSDLSTERPRAEEEPLISLTLTSIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7L9</accession>
    <name>A0A2I2G7L9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactose-binding like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_455696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704179.1">
        <property type="nucleotide sequence ID" value="XM_024851557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7L9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7L9"/>
    <dbReference type="GeneID" id="36559256"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455696"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="248"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="542" mass="60021" checksum="4C009686CDD16F95" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Q5</accession>
    <name>A0A2I2G7Q5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_494480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704218.1">
        <property type="nucleotide sequence ID" value="XM_024854073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Q5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7Q5"/>
    <dbReference type="GeneID" id="36561778"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_494480"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="35650" checksum="1703016DBE2911FB" modified="2018-02-28" version="1">MVNVAIAGGTGGVGKTIVEVMQASPHQAFILSRQLTSPKQSSTSPDNTIAVDYNSIEEVASRLEKHNIHTVISAFAVEGDSLAVSQRNLIQAADRSKTTKRFIPSGYAIPYPAAAVEVLPPLKDHFLALDELRESGLEWTLFNNGIFLDYFGPSTMKSNLKPNVFVIDVANKVAAIPGDGNSPVTFTYTYDLARFIVAALDLEKWEEESRVVGDELTWNQFVALAEACRGSKFDVYYDDVEKLKRFEITELPGHQALYEHFPKKPFQWFMSIFELFTTDGSSHVQRAGSLNHQFPHIKVLSVKEMFDLYWGQTETDKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G829</accession>
    <name>A0A2I2G829_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_509676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704326.1">
        <property type="nucleotide sequence ID" value="XM_024854697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G829"/>
    <dbReference type="GeneID" id="36562403"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509676"/>
    <dbReference type="OrthoDB" id="4399705at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="167" mass="19092" checksum="CADD964E8DD4F44D" modified="2018-02-28" version="1">MKTTNSKTIEDNKCPEKERELLRRTRRVQLERAGLQLDPTDENKVQVYVDFHKDTCRNLDDPQEVLFAAYGVLLLRSAQRRFANPKGKPAQGMTRVGLVVKTEAMRPEEVLEDAIEAVDYLRKTRRFEDMDYPIGYENVTLCLIHHGFPANGAVPSSVGVGIRLYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G876</accession>
    <name>A0A2I2G876_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_475394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704370.1">
        <property type="nucleotide sequence ID" value="XM_024853253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G876"/>
    <dbReference type="STRING" id="1392250.A0A2I2G876"/>
    <dbReference type="GeneID" id="36560951"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475394"/>
    <dbReference type="OrthoDB" id="2343925at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014139365" evidence="2">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="130" mass="14966" checksum="ABAEE31DBF1F34F4" modified="2018-02-28" version="1">MEPPSLVITLFRLELFRCLVSSSACNGADRFAGTRTQYLAQDVCRHLATMCRQFNDYGSREENNLNSINFPEFQQGEDETDDTGSQRGDNAKRSLFDIANYERECLKLAVRRLQPQIKEPVRKAWRVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8J4</accession>
    <name>A0A2I2G8J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_446915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704497.1">
        <property type="nucleotide sequence ID" value="XM_024850840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8J4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8J4"/>
    <dbReference type="GeneID" id="36558539"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446915"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="2">
        <location>
            <begin position="313"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="781" mass="89710" checksum="C74B0984246C62F1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8K6</accession>
    <name>A0A2I2G8K6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_408262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704511.1">
        <property type="nucleotide sequence ID" value="XM_024846717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8K6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8K6"/>
    <dbReference type="GeneID" id="36554416"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408262"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="169" mass="19641" checksum="D6D390294BBB6E0A" modified="2018-02-28" version="1">MSQSLRPYLQCVRSSLTAALTVSNFASQTSERHNVPEIEAQTSPELILNPLTVSRNENEKVFIEPSVNSVRVSVRIKQADEIEHILVHKFTRFLTQRAESFFILRRKPVKGYDISFLITNFHTEQLLKHQLVEFIIQFLEEVDKEISEMKLFLNARARFVAESFLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9G4</accession>
    <name>A0A2I2G9G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704810.1">
        <property type="nucleotide sequence ID" value="XM_024849285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9G4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9G4"/>
    <dbReference type="GeneID" id="36556984"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437087"/>
    <dbReference type="OrthoDB" id="5427070at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="149" mass="17018" checksum="E7C6F1B7D16F6319" modified="2018-02-28" version="1">MGSAFSFAKTIVIPAVISLALYLLLSFLIIPVFRRYQQRYSQYLPLHAISAHTSTLRDRIADTMMRFFLPASWRQQAHFEDHNDNISILDEEGELMIGMGMDPARREALERRRSTAAEPESRLTTRTRLQATAAEMACVTDSLTHPVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9T4</accession>
    <name>A0A2I2G9T4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_447269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704936.1">
        <property type="nucleotide sequence ID" value="XM_024850862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9T4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9T4"/>
    <dbReference type="GeneID" id="36558561"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447269"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="677" mass="77081" checksum="8B77065A2954B0ED" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA17</accession>
    <name>A0A2I2GA17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fucose-specific lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_356986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705026.1">
        <property type="nucleotide sequence ID" value="XM_024844187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA17"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA17"/>
    <dbReference type="GeneID" id="36551887"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356986"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22954">
        <property type="entry name" value="PLL_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058502">
        <property type="entry name" value="PLL-like_beta-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26607">
        <property type="entry name" value="DUF8189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLL-like beta propeller" evidence="1">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="328" mass="37707" checksum="8AC7B57204D0D41C" modified="2018-02-28" version="1">MAHQISALARGEERLDLFILGHDNGCYHKYRNSEKWTDWKPIGKGFSSIISAVTWGKDRLDIFCLDTSNTCYHRTLQNDKWDKWENLGGNFTSSVKAVSWGENRLDIFARGHDNTCHHQYYDGKRWSGWKSIGGSLNGGVEAVSWGKERLDVFALWAEDNTCRRKRFDGNNWSDWENLGGRLVSPIRAVSWAEDRIDLFSRGQDNGFYHQGYDGNKWSGWQSLGGQVYSHIEVISCAPNRLDVIAINRDRRCINRSFENGKWSDWKVQGDLTFFSAITGVSCRGREGQLDLFGVATHNNSVQHRSYDGNNWKDWKSLEGLVTCQLRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA32</accession>
    <name>A0A2I2GA32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_312183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705025.1">
        <property type="nucleotide sequence ID" value="XM_024843255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA32"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA32"/>
    <dbReference type="GeneID" id="36550955"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_312183"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="5"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="352" mass="38168" checksum="BFE9F23973B0DC5C" modified="2018-02-28" version="1" fragment="single">DHVFFHTNITVGTPPQEMQVYFNLIGNECWMHAANSTSCQFYKDHEDCDGYGGYNTSTSETAEFISSDFEVNDRGPNVTGAFFKDTLTIGNAKINSMTLGVSYNGITSNTVGLGYGEPGSSSVSLPQALADAKVTNSPAFSLWTDYGYNYGGMILFGGVDKAKYVDTLHTLPIVPGSSNLHKAFRVNMTGLQINKTAIAPDSFTLDAAFDIQASLSHFPESVVSYLAKQLNVQKIPESGQIMLPCSLISSKTNLTFEFGSAKFEFPIGSLMTQTSVEEAYTTDYENCYSGIVVNRKLKDEGSIVLGTNFINIVYTVFDLANDEVSLANRRWDSVSNNIVEITSGSNAVPGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAD8</accession>
    <name>A0A2I2GAD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_447415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705139.1">
        <property type="nucleotide sequence ID" value="XM_024850874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAD8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAD8"/>
    <dbReference type="GeneID" id="36558573"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447415"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="546" mass="61547" checksum="B998639BAA41E5B3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB52</accession>
    <name>A0A2I2GB52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_380484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705414.1">
        <property type="nucleotide sequence ID" value="XM_024845529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB52"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB52"/>
    <dbReference type="GeneID" id="36553228"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_380484"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013987809" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="26"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="706" mass="79715" checksum="E73DA08AED667E4C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBQ4</accession>
    <name>A0A2I2GBQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative unfolded protein response protein Orm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_141422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705605.1">
        <property type="nucleotide sequence ID" value="XM_024842470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBQ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBQ4"/>
    <dbReference type="GeneID" id="36550167"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_141422"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="181" mass="20831" checksum="24B7E032DE370B4E" modified="2018-02-28" version="1">MSQNKDKAGRRRRSSSIIYQEPAESIEHTSDQAALPNLNANWVNAKGAWTIHFVLIIALKIFYDIIPGVSQETSWTLTNISYMFGSFLMFHWVRGIPFEFNAGAYDNLNMWEQIDNGDQYTPTKKFLLCVPICLFLLSTHYTHYDLTYFTINFLATLAVVIPKLPFSHRLRIGLFSGEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBW0</accession>
    <name>A0A2I2GBW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Siderophore iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_355591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705658.1">
        <property type="nucleotide sequence ID" value="XM_024844099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBW0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBW0"/>
    <dbReference type="GeneID" id="36551799"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355591"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF55">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="549" mass="60647" checksum="9DAB39ECA099BF32" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC76</accession>
    <name>A0A2I2GC76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_424850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705786.1">
        <property type="nucleotide sequence ID" value="XM_024847594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC76"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC76"/>
    <dbReference type="GeneID" id="36555293"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424850"/>
    <dbReference type="OrthoDB" id="3872446at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="13862" checksum="7AF350CADEF5BFB6" modified="2018-02-28" version="1">MAEPEDVEEDLFADLYDADDTGNQTSSAVETSQIPQPTLSDTPTRSSEVAAPQPVERFQDHSEDPRSVYQNPQFHGGYQHDPGSQDLGFGNTAAVTTTPLETEPQGTGIKEDGRPRDLFRGDYRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCP2</accession>
    <name>A0A2I2GCP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_455113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705942.1">
        <property type="nucleotide sequence ID" value="XM_024851504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCP2"/>
    <dbReference type="GeneID" id="36559203"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455113"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="26696" checksum="2F11A7F4A1865013" modified="2018-02-28" version="1">MSLPPNFCFPVPDLSSDKVKLTPFDITKHSAPLIASTAPHPSLFNYLSWDPFPTADAFNTHFFDAYMTPSDDRTCFAVLDKTASPSSPSTDPQNEDYALAGMITLMNASPVHRSAEIGWVLTLPNYQRTHVTTHAIGLLLRYALESPAQGGLGLRRVQWIAHSENEASVRAAKRMGLRVEGVLRWHRVIVGAEERGKVGGREVGGDGYGRVEDRGRDSVVLSVCWDDWIEEVDEAVGGGLFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCT2</accession>
    <name>A0A2I2GCT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="10">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_435853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705982.1">
        <property type="nucleotide sequence ID" value="XM_024849035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCT2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCT2"/>
    <dbReference type="GeneID" id="36556734"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435853"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="78" mass="8859" checksum="EAACD47B73F8D7C0" modified="2018-02-28" version="1">MPQAQPELKKYMEKRIFCQLNGNRKVIGILRGYDVFMNIVLDEAFEEKTGGEKVAIGMVVIRGNSVVMLEALERISDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCW2</accession>
    <name>A0A2I2GCW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_354731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706026.1">
        <property type="nucleotide sequence ID" value="XM_024844055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCW2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCW2"/>
    <dbReference type="GeneID" id="36551755"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354731"/>
    <dbReference type="OrthoDB" id="3918393at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40272" checksum="1F21590C1AADCA51" modified="2018-02-28" version="1">MARFGRVKKTLKPEAENANSDALASPTSDPPPRSPRVSLPHVETQLNMHRYNGLFEPDSPERQKEPALMESATDSATLHSSIHSNGSPNPTNGDSSATEWSAVGHAATGKSGRVIHNLQEDIARLTRECSLYRSRAEETQRMNDAFKTQVENMAERLRNLETANEMNLHSITRKDNKIEELRAEAQSEKDRRRRLEEQTNKAQQLMDEARDDFNRKCAELQEVANHSRTQYDVLAKAGQRERAEQQRKFKSIRDDFIALKGRHEEKNLQLERLDTVMAQKNREIEVSRENFDRLYEDYEAYKKAQDDEVRTLIEKGRQGDAKLDAALASLKETEGQMKWVIQVKKEVKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCX6</accession>
    <name>A0A2I2GCX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_435911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706032.1">
        <property type="nucleotide sequence ID" value="XM_024849046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCX6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCX6"/>
    <dbReference type="GeneID" id="36556745"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435911"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="149" mass="16001" checksum="2EB38E20A3D85B3A" modified="2018-02-28" version="1">MFRRLAEPTGANNALSQVLYGLALRHGWGCPQDPDKAVTYLSAAASNSASIESQALQAGIKKGGAAKGELVLAIFELGNCFRNGWGVQKDPAAARQYFETAANLGDTDAMNETAWCYLEGFGGKKDKYAAAKYYRLAEEKGNNLVGNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEQ5</accession>
    <name>A0A2I2GEQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_436366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706633.1">
        <property type="nucleotide sequence ID" value="XM_024849141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEQ5"/>
    <dbReference type="GeneID" id="36556840"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436366"/>
    <dbReference type="OrthoDB" id="4342612at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="215" mass="24189" checksum="016778AC06A5EF8B" modified="2018-02-28" version="1">MRFLKHIPQKLSEFGHSHTITDFFRPVLAFQMGDLSFEDSPIQAVDQMADQAPNHQDRRRRSVRLRRRALAHEAEPNRQESPASDTLTLSLVLQDQGRGDLKHWLLYVARENQPGLCYQVVGIPPLMQYWAPDKPVDIKATRSCWNMFELGTVTAAQAAMVEEIASQEPPALALDLDAGAESCQGWTVRVLGKLYDRGVVDATSMSFVRSMLEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GET5</accession>
    <name>A0A2I2GET5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial cytochrome b2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_474914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706674.1">
        <property type="nucleotide sequence ID" value="XM_024853197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GET5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GET5"/>
    <dbReference type="GeneID" id="36560895"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474914"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="100"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="50827" checksum="4129FA81F8E4D66C" modified="2018-02-28" version="1">MAKRLTVRELQLHASSESCWIALCGRVYDITGFLGHHPGGSSILLNLAGQDATKEYDLVHPPGLVDEHLSSSFLGLLEIDPPAAGDETLEPERSTSAGTISVKQALNLHEIEALAKERLPHKAWAYYVSAADDNLSKTRNNSVYQSILLRPRVFVDCTACNPSTTVLGHHLGMPIYASPAAKARMAHPSGEAGIATACAKFGALQIISHNASMDLVDIVRGAPKDQVFGWQLYCLNDVRQSERRIQKVNQIKQIKFIVLTLDAPFPGKREVELRSTMDFSRSNAPPQVWGTDASLAWEKTLPWLRKHTDLPIVLKGIQTYEDAVLAARYAPTVSGIIISNHGGRALDTAPSPIETLLEIHHHCPEVFPRLDVMVDGGIKRGTDVVKALALGAKAVGIGRAPLWGLAAGGPAGVERVLEILSEETATAMRLLGVSNVKQLSRQHVNTRALESGIFTSAWDKGERVESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFE5</accession>
    <name>A0A2I2GFE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hemolysin-III family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_443783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706908.1">
        <property type="nucleotide sequence ID" value="XM_024850583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFE5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFE5"/>
    <dbReference type="GeneID" id="36558282"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443783"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="315" mass="35636" checksum="4B219CB129FD6F9A" modified="2018-02-28" version="1">MESAPRLRVPPLQSPEGMESISTTTAYKAGNAGYPVLLSFDEMPEWFRRECNPWILRGYRPISGSAHASFSSWSYIHNESVNIYSHLIPAIFFLLGEWYIQQYFTSRYSGFTGADFIAFSIFMLTAVTCLSLSATYHTLMNHSKHVEHFCLRLDMLGIVIFILGDLILGIYMVFWCEPLPRNIYWSMIGVFGTLTIFMTMHPKLQGSKYRLFRALMFVATGLSGIAPLVHGLNVFGMSKMMRKAFPYTMAKAGCLLSGTAFYATRFPESQYPGKFDLWGSHSIFHILVVCAAIVQLMGYLDAYDYAQTNLTCSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFR1</accession>
    <name>A0A2I2GFR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_433588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707022.1">
        <property type="nucleotide sequence ID" value="XM_024848528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFR1"/>
    <dbReference type="GeneID" id="36556227"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433588"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF6">
        <property type="entry name" value="LETM1 RBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="203"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB51720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="376" mass="41258" checksum="E27FC8719CDA268A" modified="2018-02-28" version="1">MSVSLAPRRALFARPPPYTVAPLVSLFRHRELATSRRYASHSSSTKSHSRPSSSAQPATSAAPSTSSTATTSLADDVNPPPSTRPADLNLPDAIASSASAAEKLKRYVAMGRAYLSFYKTGLKNVYHNYRASIPLRSSLGLAPYLPISPPPPAKGGKAAAFRDAVHALHLSRSNFQLIRRAAYDIRRMIPFTLMLIVCGEFTPLIVLALGSAVTPFTCRVPRQLEKDRTQSIARKRAALTAHEVARSGSMSPVAAGSEPELDLLARAYTRPAWIESASAEEILRACATLGLVKSHTRSTALVSLLYRARLQRYAEYLDLDDRLIRRCGGVTAMEAAEVRIAVDERGGVGLAEGSEGWDVEREERRWLERWLERREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFR9</accession>
    <name>A0A2I2GFR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha,alpha-trehalose-phosphate synthase subunit Tps2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_433604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707035.1">
        <property type="nucleotide sequence ID" value="XM_024848532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFR9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFR9"/>
    <dbReference type="GeneID" id="36556231"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433604"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000052">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="929" mass="103655" checksum="A2B09B0228910D86" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG99</accession>
    <name>A0A2I2GG99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_401610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707206.1">
        <property type="nucleotide sequence ID" value="XM_024846380.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GG99"/>
    <dbReference type="GeneID" id="36554079"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401610"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140278">
        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11889">
        <property type="entry name" value="SH3_Cyk3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000005">
        <property type="entry name" value="SH3 domain protein (Cyk3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035553">
        <property type="entry name" value="Cyk3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1283" mass="140237" checksum="1C41A820C02D005D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGF7</accession>
    <name>A0A2I2GGF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_401689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707242.1">
        <property type="nucleotide sequence ID" value="XM_024846384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGF7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGF7"/>
    <dbReference type="GeneID" id="36554083"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401689"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="29"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="386" mass="44505" checksum="59706FF035C0E8E3" modified="2018-02-28" version="1">MSSTTETASASPIGIANLPNQRHKIVAKRGAAFTVMVAGESGLGKTTFINTLFSTTIKNYADHKRRHQKQIDRTVEIEITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWQPIIEFLDDQHESYMLQEQQPRRTDKIDMRVHACLYFIRPTGHTLKPLDIEVMKRLSSRVNLIPVIAKADTLSPADLARYKQRVQAVIEAQGIKIYTPPVEEDDEHAAAHARSLVAAMPFAVIGSEKDVKTSDNRVVKGRQYAWGVAEVENEDHCDFKKLRSILIRTHMLDLIHTTEEQHYEAYRAQQMETRKFGEARPRKLDNPKFKEEEESLRKRFTEQVKVEEQRFRQWEQKLISERDRLNKDLEATHAAIKSLEQEIEGLQGSSTRSHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGH8</accession>
    <name>A0A2I2GGH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_471900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707287.1">
        <property type="nucleotide sequence ID" value="XM_024852881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGH8"/>
    <dbReference type="GeneID" id="36560579"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471900"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="205" mass="21640" checksum="5FE1A052CA9DF58B" modified="2018-02-28" version="1">MTNSSESVNYRFPNTMQLATSLTAALSTAGVGPAVAFNPSTVVASSSSTPSPSITPASTSAIASDMSVTMIKTKEGECFLEFENVLGCTGRSELIGDYDDETGCVPAGIAEPIVGDICGNHVTFYPVHDNYIYVEQADQNMEVQSGDVYYSNGTNWIGHQLGLSPGCSFRASGQAIVGPQEWCLPENDGYSRVPDVPSYQPTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGI7</accession>
    <name>A0A2I2GGI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_471908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707295.1">
        <property type="nucleotide sequence ID" value="XM_024852882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGI7"/>
    <dbReference type="GeneID" id="36560580"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471908"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28996" checksum="6DFB5F116EA61D4B" modified="2018-02-28" version="1">MDVPVAANVLGTIGAVCWSIQLLPQIIINYRRHDTEGLQPSMMLLWAAAGVPLGVYNIVENFNVALRIQPQILTALSLLTWAQCLYYGKKYTIPKCIAAVVPLLAGLGGIEVGLVFALKAALNRDLSWPMTLMAVLSACLLAAGVLTHYWDIYVHRTVRGISFLFVGIDAAGDLFSLVSVLFEPTIDVLGMVIYGTELALWIGIFICGGVFNLRPWIQSRRKKHHEQEQEPVSLHEMPSSTSVFRTVSGSEVVGRRPRTHASDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGJ6</accession>
    <name>A0A2I2GGJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_506913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707313.1">
        <property type="nucleotide sequence ID" value="XM_024854424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGJ6"/>
    <dbReference type="GeneID" id="36562130"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506913"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="282" mass="30015" checksum="6D8FE0C2026F6A3D" modified="2018-02-28" version="1">MSQPTPQMPKTVLITGCSAGGIGAALVEAFHERGLYVFATARTVSKMSQLEHLPNVTLLQLDVSSQSSIDAAVEAVTAKTGGTLDYLINNSGQSCIQPALETTLERARAIHDVNFWGTVSVTQAFSPLVIKAKGTIANICSIAAVLPVAWGAFYNSSKAAVLSYSETLRLELAPLDVKVITVMSGVVRTNIFSNHPEANLADTSPWKPAEQVLIDTAAGSMVDGATPRGVFARRVVDDVLGDKTGLTWVGKMSSVAWWMAGFAPKWLLDRILVSSGGLDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGT0</accession>
    <name>A0A2I2GGT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_335673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707393.1">
        <property type="nucleotide sequence ID" value="XM_024843379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGT0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGT0"/>
    <dbReference type="GeneID" id="36551079"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_335673"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="136" mass="15202" checksum="EE85E2243B943A4F" modified="2018-02-28" version="1" fragment="single">YQRTYKACVPCRRRKVKCQPGDQAHQPCCRCAKFELECRFDDRTPWAREGGGLNRMVSSSNDALGILFRAAAGEAGSATIGHGDTRHPATQGIHMAFSRPHCLPHADVLRVWDACRFVKMGWFSAFEAFTLVDLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH10</accession>
    <name>A0A2I2GH10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_434003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707470.1">
        <property type="nucleotide sequence ID" value="XM_024848625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH10"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH10"/>
    <dbReference type="GeneID" id="36556324"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434003"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="188" mass="21032" checksum="A913C84A7F242123" modified="2018-02-28" version="1">MPAYHSIFLEDRDVPVIGNFPVLPLRTRTRGPAYTLPPLPPNTSDADVAPDSESYDCVDEILSLFRANVLFRNFEINGPADRMLIYGTLFISECLGKVRPSMSSLEASKALNNVALDQFAIPGDATFPLNQAFEPPRDRQDAEGLRAYLSQVRQEIAIRLHARLYPGGVGPSKWWLSFAKRKFMGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH22</accession>
    <name>A0A2I2GH22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_507031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707474.1">
        <property type="nucleotide sequence ID" value="XM_024854437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH22"/>
    <dbReference type="GeneID" id="36562143"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507031"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="53"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="225"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="420"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="9">
        <location>
            <begin position="765"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="865" mass="98721" checksum="5B1138D9C012E691" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHC3</accession>
    <name>A0A2I2GHC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_507114</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707585.1">
        <property type="nucleotide sequence ID" value="XM_024854449.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GHC3"/>
    <dbReference type="GeneID" id="36562155"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507114"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="362"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1358"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1374"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1395"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1421"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1431"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1447"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB52283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1682" mass="185795" checksum="49B061828E15D26F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHJ4</accession>
    <name>A0A2I2GHJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_444360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707654.1">
        <property type="nucleotide sequence ID" value="XM_024850627.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GHJ4"/>
    <dbReference type="GeneID" id="36558326"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444360"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="292"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1503"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB52352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1606" mass="177542" checksum="70A088AA61309B47" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHW7</accession>
    <name>A0A2I2GHW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_507263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707774.1">
        <property type="nucleotide sequence ID" value="XM_024854464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHW7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHW7"/>
    <dbReference type="GeneID" id="36562170"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507263"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="18"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="441" mass="47912" checksum="00EC01516C5E0293" modified="2018-02-28" version="1">MTPKKHPRDWSPIRKVITTIIICGIGFTVTVGASIYSPGHEQVQQEFNVPTTISLLPLSAYSLGLAFGPMISSPLSEAFGRRFVYLITLPLFDIFMVGVGLSRNIASLIICRFFAGLFAAPGVSVAAATIADYTTPSERAIPLCTYYSIPFTGSAIGPLIGGFAVDAKEWRWTAWVVLIMGAALHTPVLFLRESQTSLSKGNSDGGVWETGKHFITTTVIRPLHMLTTEPLVTSICLYTGFQFALLYTFVVASPWVFRTVYAFSSQAQSLSFLGMVTGCLTAPPVLISIDRLIKRLRPPTSQTPSTPEDRLHAALYGSLVLPAGLFWFAWTAQPSIHWMSPICAQGLTLLGSILIYVPCNFYTIDVYGSKFGASASGASSLTRYTLSAAFPLFVTQMYEALGVHWATSLLGFVALAMAPIPWLLYRAGPGFRARSGYEHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHW9</accession>
    <name>A0A2I2GHW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_444453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707772.1">
        <property type="nucleotide sequence ID" value="XM_024850631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHW9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHW9"/>
    <dbReference type="GeneID" id="36558330"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444453"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="304" mass="33240" checksum="D273392660A469FE" modified="2018-02-28" version="1">MSTLPGGLIAFGPDANCTLSLCPLEASILRYKPSIPASCVCIAIFGLSLAVHTLQGWKARSWGFMASVIAGCILEIIGYVGRLIIYNNPFDFNGFLMQIICITVAPVFFCSAIYVLLSQSINHIDASLSRFKAKYFYWIFIPCDIVSLILQAVGGALSCIGTTEDDINVGVNISLGGLVFQVVTLVAFLGLFADYLSTCWRSPARKAFNGHMKIFLGFMFLSVFLILVRCVYRIVELHAGYFSETFRDEPLFIALESAIMCAAAVCLHPGHPGLVFRRGQNYNRGLDGNSFVSGEELKPRADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI77</accession>
    <name>A0A2I2GI77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_402882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707884.1">
        <property type="nucleotide sequence ID" value="XM_024846452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI77"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI77"/>
    <dbReference type="GeneID" id="36554151"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402882"/>
    <dbReference type="OrthoDB" id="3057599at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="93676" checksum="FEF5F5145E2642EF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIE9</accession>
    <name>A0A2I2GIE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_351738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707957.1">
        <property type="nucleotide sequence ID" value="XM_024843887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIE9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIE9"/>
    <dbReference type="GeneID" id="36551587"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351738"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="197"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="922" mass="105056" checksum="C77FB324929500A7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ52</accession>
    <name>A0A2I2GJ52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_116250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708208.1">
        <property type="nucleotide sequence ID" value="XM_024842336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ52"/>
    <dbReference type="GeneID" id="36550031"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_116250"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="104" mass="10546" checksum="3665786CC316A695" modified="2018-02-28" version="1">MEAKDSDVECVRALGINPPSNSSKSESSSSSSSCAAAGLGCFWACDGLGSADVEGVLVFAFSVVFFSAVVDVCSAGVSSRGSTAGGADEEAMLSDWLRKGSKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKX8</accession>
    <name>A0A2I2GKX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_400836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708833.1">
        <property type="nucleotide sequence ID" value="XM_024846348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKX8"/>
    <dbReference type="GeneID" id="36554047"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400836"/>
    <dbReference type="OrthoDB" id="2446447at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="225" mass="24754" checksum="5BF640F088A24508" modified="2018-02-28" version="1">MTSEIRQYHLPPTDLIPNSPRPLLHYKNVLRKKPNTSHCDPAEVWDLFTKNEWNVHWIFRYSHTQVSHYHSQAHECMAVLSGTASIRFGVGDTSADMKENTDGSAWDKGGVLLEANAGDVFIIPAGVAHKTHNTKPEAEFALLSPGTGHGIEAEDPKKALSEVKLDGFTMMGAYSGGDWDFVATGGDFEKVWAVPKPRFDPVLGDSDRGLCKAWRGSGTEAKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL33</accession>
    <name>A0A2I2GL33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylglycine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_454568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708861.1">
        <property type="nucleotide sequence ID" value="XM_024851450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL33"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL33"/>
    <dbReference type="GeneID" id="36559149"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454568"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="399"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="705"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB53559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="808" mass="89071" checksum="0F34129C7592FB03" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLG6</accession>
    <name>A0A2I2GLG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-actinin, sarcomeric</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_431547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709028.1">
        <property type="nucleotide sequence ID" value="XM_024848061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLG6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLG6"/>
    <dbReference type="GeneID" id="36555760"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431547"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="74063" checksum="115C8E2EA87C90F6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLQ5</accession>
    <name>A0A2I2GLQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_442060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709109.1">
        <property type="nucleotide sequence ID" value="XM_024850436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLQ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLQ5"/>
    <dbReference type="GeneID" id="36558135"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442060"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019622">
        <property type="term" value="P:3-(3-hydroxy)phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="634" mass="71978" checksum="A9BFA94390A2DD44" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM97</accession>
    <name>A0A2I2GM97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_460272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709296.1">
        <property type="nucleotide sequence ID" value="XM_024851925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM97"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM97"/>
    <dbReference type="GeneID" id="36559623"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460272"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="762" mass="84702" checksum="68DF1FC41F66C534" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMD2</accession>
    <name>A0A2I2GMD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_7523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709344.1">
        <property type="nucleotide sequence ID" value="XM_024855365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMD2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMD2"/>
    <dbReference type="GeneID" id="36563072"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_7523"/>
    <dbReference type="OrthoDB" id="4496550at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190643" description="Fungal N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45892" checksum="AB422BC0FF00AE42" modified="2018-02-28" version="1">MEGASAAITFIQLGLSLATTLNTYIADVRHGRDDVANLANEIEATVSHAQELDKLIQENKLTERWSDHGAFLAQKCLTDCHDVIKRLATLLRRSGGTAPGMPVLNGADEVESSDTKSLISRTDIDMSNFNRLYWPMLKPQLQYLKQELQKIKIEILLAVNTYQVNATPKADERKAIAERIVALWRSRTVARRQLVVYGRELETPYEDYYRPYTRGPRRYDDRERERGITEPDPGPNDGPRDQDRGYPPASPPRSPPRYSRRQRSPVIIREQTPRRDSDDYDFRYFPRPERNGLPFAPDLDDAPEKSRGRQIIDYMLGFVLAPGEDAVGTRQKLNHVWDSYKHNPAALRSHGSSPEASECECPSSRSQRPRIANRRGIYLVSAHLEQIPRAHRGTLQLSARAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPK4</accession>
    <name>A0A2I2GPK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_374173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710095.1">
        <property type="nucleotide sequence ID" value="XM_024845274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPK4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPK4"/>
    <dbReference type="GeneID" id="36552974"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374173"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="765"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114764" checksum="8BA96BC3DCA853B4" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQR0</accession>
    <name>A0A2I2GQR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_461141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710524.1">
        <property type="nucleotide sequence ID" value="XM_024852004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQR0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQR0"/>
    <dbReference type="GeneID" id="36559702"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461141"/>
    <dbReference type="OrthoDB" id="2279190at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF6">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="165" mass="18911" checksum="A132042C60A82AB5" modified="2018-02-28" version="1">MATATAEKPKEQKRFQQQQDDYSDDDYDSDEYSISGDEDDYAPQKPSQKQQQQRRRQPNQQRRPADDEDDYLSDDYSTDEYDDDYEDADEEVPNNAMQPFKRGQQSLTNQGISSQDPVQNGAMNTVDKGGEEKDDGLRLTLELNLEIEVELKAHIHGDLTLSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQR6</accession>
    <name>A0A2I2GQR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_347121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710521.1">
        <property type="nucleotide sequence ID" value="XM_024843607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQR6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQR6"/>
    <dbReference type="GeneID" id="36551307"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347121"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000021">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="79"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="274"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="431" mass="46736" checksum="C560579199DE20AA" modified="2018-02-28" version="1">MTGLSGNGSPEPNERDALISDINRANSGLRPRHKHNRHWSYWPAQAVRLTWSTLVRDYVNLLLVFVPLGIIAGALHWDSTVIFTLNFLAIIPLASLLSFATEELAATMGQALGGLMNATFGNAVELIVSIIALKDEQIRVVQASMLGSILSNILLVLGCCFFVGGLRYSEQTFNSTVASTMSSLMTVASASLIIPATLYASLSSSSDSKDTQKNILILSHGTAIILLILYVMYLYFQLKTHAQLFEEASVNDEENPGQNADEAEEEHLLSPWAATVALVIVTILVAICADYLVGSIDSIVEKTGMSRTFIGLILIPIVGNAAEHVTAVVVAWKGKMDLAIGVAVGSSLQIALFVTPFLVILGWIMDIDMTLHFHIFETVAFFISGLVVTFLIQDGKSNYLEGGLCLGMYVILALAFYVYPDNVNEDALFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQU7</accession>
    <name>A0A2I2GQU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_432782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710552.1">
        <property type="nucleotide sequence ID" value="XM_024848338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQU7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQU7"/>
    <dbReference type="GeneID" id="36556037"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432782"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="3">
        <location>
            <begin position="625"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="808"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="878" mass="98126" checksum="D94C4D3F22AC5A6B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR73</accession>
    <name>A0A2I2GR73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">P170DRAFT_505946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR73"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR73"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505946"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="315" mass="35255" checksum="C32FB83F4EBA5398" modified="2018-02-28" version="1">MLSRSLWRSLRLNARRGVNVPETPYRCFSCTVRAQAASNKSETDRMTHFGFTNVPEADKESMVRSVFSSVASSYDAMNDFMSLGIHRLWKDHFVRTLNPGSALPSCETDTAGRGWNILDIAGGTGDIAFRMLDHATNINHDRETRVTIADINPEMLAEGKKRSIQTPYYNTNRLSFMEGNAQHMPSIPDNSVDLYTVVFGIRNFTDKQAALVEAFRVLKPGGVFACMEFSKVDNALFNTVYKQWSFNAIPMIGQLVAGDRDSYQYLVESIEKFPSQEEFRGMIQKAGFMIPGRGFENLTGGIAAIHKGIKPLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRC0</accession>
    <name>A0A2I2GRC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_452811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710724.1">
        <property type="nucleotide sequence ID" value="XM_024851304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRC0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRC0"/>
    <dbReference type="GeneID" id="36559003"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452811"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="136"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="489" mass="54028" checksum="48BD6010F0E5F1C4" modified="2018-02-28" version="1">MPPRGTRKASGGAPRSAEPTSPASKRKTNGTAEIDSSPRRSKRVKSTDELKAISVNGTVKEEVGEETKDAVDVVADEVDEKPAVTEKGPKKRKTKQEKEAEMLPLRARTPGLRMFVGAHVSAAKGVFNSITNSTHIGGNAFALFLKSQRKWDNPPLQDDHRDQFRKMCAEHKYDAAQHILPHGSYLVNLAQEDKAKAKQAYDSFLDDLRRCEALGIKLYNFHPGSANQTPHASALTRLAKALTNALTATTTVIPVLETMCGHGSTIGGQLSEFRDLLALIPPEHHPRIGICIDTCHSFAAGYDLTSRAGFQSFLAEFESQIGLQHLRALHLNDSKAPRGSRRDLHANIGTGFLGLRAFHNVMNEPRFENLPMILETPIDRPDPKAGKGKKPSTVADPRVWADEIALLESLIGMDVEGEEFKGLERKLAEEGREMREKQQEQYDRKVETEKKKQAKGGQRSLMDMMGGKKKKGKKEDESEDEGCQSHSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQQ9</accession>
    <name>A0A2I2FQQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_487088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000018">
        <property type="protein sequence ID" value="PLB42936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_487088"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="133" mass="14245" checksum="C391E8ECBE262155" modified="2018-02-28" version="1">MPSRPRVHQLVPITSLPFVNTARRLLPIEWLGEAFGLAQGSWQRPPRAGKLSNPGHLEENSVNHRVFETHIAPPWYSGGYACPSVISALKHGLCVGSSSPPGRARKAAAAPRPAALADAEKQPIIFQVDLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR86</accession>
    <name>A0A2I2FR86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_459646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698444.1">
        <property type="nucleotide sequence ID" value="XM_024851881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR86"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR86"/>
    <dbReference type="GeneID" id="36559579"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459646"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="66"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="452" mass="49222" checksum="1183654447D35711" modified="2018-02-28" version="1">MAASQAANIAEKVVGHSDNATIETDVSNYAKGDYGQETGEKIKATVWQGKNCVEVVEMPKPRVINESDVIVKITGSTICGSDLHLYHGVIPQLEKGDVLGHEFCGVVESVGPKATKVKAGDRVVAAFPIACGDCTNCQKQLTSSCERTNENTIENVMYGKRTSGMFGYSHFTGGFAGGQAEYVRVPYGDMNLLQLPDDVPDEKGLYLSDVLATSYHCVVDTGVTPGDVVAVWGAGPIGQMVVGFSFGQGASRVILIDGGEAAWRLDFVKSKVPKVETLDFSQLPRGESITSQLKKIVPGGPDVALDCAAGEYAKGWAHYFEMLLGMETDTSELLNEMITSVRPFGRIGITGIYAGYTNHFNIGAIMQTGIRLIGNGQAPVHRYWHHLLELIRRQEIDPLDMVTHRVRLEDMPQLYALFERREQGLQKAFVQTKFSFPPSAGAPRLTELQEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRB6</accession>
    <name>A0A2I2FRB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative class III chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698451.1">
        <property type="nucleotide sequence ID" value="XM_024850353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRB6"/>
    <dbReference type="SMR" id="A0A2I2FRB6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRB6"/>
    <dbReference type="GeneID" id="36558052"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441608"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06546">
        <property type="entry name" value="GH18_CTS3_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="11"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="311" mass="34595" checksum="0549A2C28B335603" modified="2018-02-28" version="1">MPPVPPSAERCRVVCYHQTICADGQYVSMLPLIQHNTGITHVILAAFHLNADPHHITLNNDPPDHSMYDMLWTEVPLMKQRGVRIMGMLGGAAQGSFRSLDGDLESFDRYYQPLLATIRRLQLDGMDLDVEENMSLSGIIRLIDRLKADLGDAFIVTLAPVAAALLGIGNLSGFDYHDLEQQRASKISWYNAQFYNGWGPADDPRMYAAIISRGWSPQRVVYGLLTNPGNGSQGYVPLETIGPILGHLVKEYPNFGGVMGWEYFNSYPGGREKPWQWAAVMSLSMHMKDLVMAATELNNLVASLVRNMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSA4</accession>
    <name>A0A2I2FSA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_450751</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698799.1">
        <property type="nucleotide sequence ID" value="XM_024851143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSA4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSA4"/>
    <dbReference type="GeneID" id="36558842"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450751"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB43497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="151" mass="15753" checksum="5AEAA78135AD7266" modified="2018-02-28" version="1">MADSEFAPKFSPFFSFTAMGAAYGTAKAGIAISGVGTFRPDLIMKSLIPVIMSGIIAVYGLVVAVVIHGDLDRDHSQALYTGFMHLGAGLSVGFTGLAAGYAIGIIGDAGVRAYMQQSRVYVGMILILIFAEVLGLYGLIVGLILNSKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSE7</accession>
    <name>A0A2I2FSE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_459208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698828.1">
        <property type="nucleotide sequence ID" value="XM_024851849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSE7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSE7"/>
    <dbReference type="GeneID" id="36559547"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459208"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="554"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118377" checksum="8B88F5E896F29A3A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSM4</accession>
    <name>A0A2I2FSM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_430663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698913.1">
        <property type="nucleotide sequence ID" value="XM_024847968.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FSM4"/>
    <dbReference type="GeneID" id="36555667"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430663"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1361"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="7">
        <location>
            <begin position="326"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="815"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1130"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1408" mass="152949" checksum="D03BBDF9FF060729" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSR2</accession>
    <name>A0A2I2FSR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_450874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698975.1">
        <property type="nucleotide sequence ID" value="XM_024851150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSR2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSR2"/>
    <dbReference type="GeneID" id="36558849"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450874"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="499"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="646" mass="73076" checksum="523A8BB76C554864" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSS2</accession>
    <name>A0A2I2FSS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698966.1">
        <property type="nucleotide sequence ID" value="XM_024850236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSS2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSS2"/>
    <dbReference type="GeneID" id="36557935"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441121"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="168" mass="17943" checksum="0A3FE27E5BD254A5" modified="2018-02-28" version="1" fragment="single">MADARKRPQSETERQSPSSTSLAHRTRAPPTAQHTRRQISPSSGPRDAAVSANPVTHGANPGAADDDDEDDYTSSSGSDSDSDGDDSDDAERSDDQHARRLDSDVKSHDGDASAGAGAGADADQRMPHVSGRAKPRIHRVQDDQGLMSRLSAFLPQMKSANEDLQREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU90</accession>
    <name>A0A2I2FU90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_513438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699515.1">
        <property type="nucleotide sequence ID" value="XM_024855109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU90"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU90"/>
    <dbReference type="GeneID" id="36562815"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513438"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="763" mass="86023" checksum="3E971080B7BBECD4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUR8</accession>
    <name>A0A2I2FUR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_458955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699653.1">
        <property type="nucleotide sequence ID" value="XM_024851830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUR8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUR8"/>
    <dbReference type="GeneID" id="36559528"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458955"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="473"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB44351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="714" mass="79348" checksum="A7A884DAAC6C3BFE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUU0</accession>
    <name>A0A2I2FUU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box and WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_468107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699711.1">
        <property type="nucleotide sequence ID" value="XM_024852529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUU0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUU0"/>
    <dbReference type="GeneID" id="36560227"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468107"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1125" mass="122358" checksum="61781937C5651407" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV04</accession>
    <name>A0A2I2FV04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_459014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699754.1">
        <property type="nucleotide sequence ID" value="XM_024851834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV04"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV04"/>
    <dbReference type="GeneID" id="36559532"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459014"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="790"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1109" mass="119031" checksum="FF8472C61113C5E7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV27</accession>
    <name>A0A2I2FV27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_459036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699795.1">
        <property type="nucleotide sequence ID" value="XM_024851835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV27"/>
    <dbReference type="GeneID" id="36559533"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459036"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014137999" description="Extracellular protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="31286" checksum="50AC1BD91C8FD4D0" modified="2018-02-28" version="1">MMKSLLLAGGLLASSVAGHIQMSNPYPIRSPLNKDGSGQKDYSYTNPLSTDGSDYPCKGYANDPFTSVATYSPGSSYNLELEGSAVHGGGSCQIALSYDTGSTWKVIHSMLGGCPITKSYQFTIPSDAQNGEALLAWSWFNKVGNREMYMNCAQVTIGGGANREMTTDLVRRDSFSSLPELFRANTGGPAGCKTIEGEEVNFPLPGPSVEGSLSGKGYECSGSAPFLGGGHGTNAANGISSGFTSNNNTSSDSSSSTCTNGSIVCGADANSWSLCDNGQVIHMGTVAPGTQCRHGAMQRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV91</accession>
    <name>A0A2I2FV91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_417241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699844.1">
        <property type="nucleotide sequence ID" value="XM_024847166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV91"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV91"/>
    <dbReference type="GeneID" id="36554865"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_417241"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="216"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB44542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="366" mass="42620" checksum="3D80B9C9E2C9830D" modified="2018-02-28" version="1">MDFAALMAKEISKAKPPSEKKESSAATNAPEKKYMRRADVEAARIAAYNEEQERLQREREERQTQKRKLEDEEAERRHEREEKKRRLAEESRKRREEEEAEQERQRRKRLGLPELPAAGDKDSDALGDQEEDIPDEELVGKLRELGEPVTLFGETHRGRLRRYRRVMQRALAPQPKLSDGPIPTTLELVPEVEMKISTTLPKDVEGRKYLFRQLASYFNMVLKEWELALAKRDATVKQSLQGRQAYNAMVQSRDNLKPLFRKFEKVDLDDGVLEHIVEIAHKAQQRRYVDANDAYLRLSIGKAAWPIGVTMVGIHERSAREKLHQSDQQAHILSDESTRKYLQSIKRCLSFAQTRWPPDDQLQIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV95</accession>
    <name>A0A2I2FV95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_468214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699865.1">
        <property type="nucleotide sequence ID" value="XM_024852541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV95"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV95"/>
    <dbReference type="GeneID" id="36560239"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468214"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF14">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="375" mass="42518" checksum="38688E97504925EA" modified="2018-02-28" version="1">MLRRRAHKKSRRGCSECKKRHIKCDESVPQCGFCLGRKLDCMYGDSVAPATPSPKAQSPDSSSNRLLEAKLLHHYYTNTSNTVSSPSDYHQWHNLFPEAATSHAYVLDSVLAFTALHFAYLEPNSRQTWLEIGSHYNNRACSELRRVVGQVSASTLRPALVCSIYIALFANARIALLGDKIQSSHLADILQTRTLLKGCLFFHQTMENMNIRSGLRMEQYLWRDNPSENPSSPSPVVPGPTVRRMGTLVLEKFKTEPGQGNQSRFEICAIACQGLIDSMDSQYTVETQGRNLFLWPLSLDDSFMELLQTNEFPARLVFSLYALGIHFFKGFWYIGEAGYRLGRELLPLSEPVSEYWVDVTTSLRAEFEIDRAVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWB3</accession>
    <name>A0A2I2FWB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_367275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700220.1">
        <property type="nucleotide sequence ID" value="XM_024844801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWB3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWB3"/>
    <dbReference type="GeneID" id="36552501"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367275"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="553" mass="61130" checksum="9EBF2663C1BBD6DB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWK9</accession>
    <name>A0A2I2FWK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_458610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700322.1">
        <property type="nucleotide sequence ID" value="XM_024851807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWK9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWK9"/>
    <dbReference type="GeneID" id="36559505"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458610"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30018" checksum="D2072CB87869B452" modified="2018-02-28" version="1">MLVSEKVREIALVWFTAQVIIFPIIQATRCFWRDNSLALDEYEPCFPTRANSGCCGTNKKGDQINDICLSNGLCYAQVRPYTGLILQNTCTDQSWKSSDCPKICPEDMRTTFGIHVLPCPRYSNRHWCCSSNGSDCCDNAFEMDMGTLMLPSDNAPTTVSGKVSTSTATVFSTVTSKIKTPGGGSDEDKQKTTLVGAGVGAGLGACILAMAGALWFQRRMYEKRLRESKAIQAQTFDQNYAPVRVMPPAELPPNYQQTVYEMPAGSPGGRGLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWZ6</accession>
    <name>A0A2I2FWZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_365976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700462.1">
        <property type="nucleotide sequence ID" value="XM_024844738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWZ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWZ6"/>
    <dbReference type="GeneID" id="36552438"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365976"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000391">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF60">
        <property type="entry name" value="RNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_1G02950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="279"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="446" mass="48182" checksum="EFC0B7E68BE46E4A" modified="2018-02-28" version="1">MPAPQKARMTKSRGSDEEFVLFLQGIPAHCRWQELKDMVRQTALHIRQAVVYDDNHGFPTGLGQIIVKNEDEAWRTYHRLSTNGWEGQSLVVTLARTSSPTRPIAGPTKSPTCVIPPNYVAGYSTPPRVTQNLAVPPSPMTPEPVNSNSPTYQTPDYGAPMMSPMGMPQPFMPIFADPLTHTMPGFPPSPVLRASYCDPNFAFAFLPPYALPPMPHPLHEASLNAMRMNSGTASNNRPTKPIHGLPIQHRHSLNPNSPIWPASCRAPGPGPTGRPFSRRTIFIQNLSVTTTKKDLENFLQGPNNTGIEQSEIPTDAETGRCKGFARVTFHHADEAKRAVARYNNAIFMGAKIRVKIDRSIHVAYSSSQGPPRAAPGPDDAANTASTGTPSSPTAPEGPAEENKVSPVLPAGTSPGAGGRRESLPKIDRCQPLVVNGSGIGRRAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXC7</accession>
    <name>A0A2I2FXC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_467829</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700593.1">
        <property type="nucleotide sequence ID" value="XM_024852495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXC7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXC7"/>
    <dbReference type="GeneID" id="36560193"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467829"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB45291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="253" mass="27625" checksum="01C85A64789568AA" modified="2018-02-28" version="1">MHLASLGAPARSSALGVRFPSSVLAPFTCPTGSTALYHVTSVPSQARSASTSAAHIKALQTSTNTLKTSARPQIPSSLTIYRTASLRANSTISDASRHEASKLDWNSFFKLRASRRRYSLASSIVSSMASTVIGVQVLSTQDLEHMGAQVMGLDPFVVLGMATAACGAAGWLIGPFLGNAVWGLVYRRYRTAVAVKEKEFFDRIKRFRVDPSSNSIANPVPDYYGEKIGSVQGYRQWLKDQRAYNRKRRSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXZ1</accession>
    <name>A0A2I2FXZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HlyIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_364248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700758.1">
        <property type="nucleotide sequence ID" value="XM_024844635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXZ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXZ1"/>
    <dbReference type="GeneID" id="36552335"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364248"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="499" mass="56605" checksum="6F3B1EDE08BDA464" modified="2018-02-28" version="1">MACSAQSMTIESYPEASSSSYATPSEETELLRDRRRRHSFHTARKLSCDYDADAVFLRVELFLAELERRMHWIEEYRRSHMVQVDSSLRRGYATLEAVRDSCSHASGELMGSGKKRAKILVETLEDRYNDALATKETLEQKAQAGIRLMESFLTELESRAHAVRDRGIYGALDDGWKAVDSKLVHAREVVDEGMERARKAKEALRENIDQAIMLAKEQRLITYADLPHPWRVNPHILQGYRFTSSKVECFTSMFTYSNEMFNIWSHLIGLFIVLSVAFYFYPLNPNFHLSTNTDVLIAAVFFFAACKCLVCSTLWHTMSSIANQGLMERFACVDYTGISMLVAASIVTTEYTAFYCEPVSRWTYILTTMSLGVGGVILPWHPTFNRADLAWARVAFYVTLALTGFAPLAQLTYTRGFSWCLYFYAPVVKSIMVYFVGACVYASQVPERWSPGLFDYVGGSHNIWHLAVLGGILFHYCAMQDLFANAFQRAKGECPNLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYE0</accession>
    <name>A0A2I2FYE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_500225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700940.1">
        <property type="nucleotide sequence ID" value="XM_024854146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYE0"/>
    <dbReference type="GeneID" id="36561851"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_500225"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41773" checksum="466979997B3BC348" modified="2018-02-28" version="1">MSAFSIDEAMAIALDNLNRISCHFRKHEQHTAANELGKLSVQIVNAFSNGVDQLPPDQHAFSGLITQIERINKENVTSHAGILQQISCSDEKASQQPESWAQVASTSATSVSGLQTYCPEPSHYMTPQSLTSASVSRHSQNSDDDGSDPQLPSLSGVALPSATEAPEIPEAKAGVIRIYGRISKDLIQFITTRIHEGPLQDVRLETNGRTRVTFQHASHALAFLKSNQEMEHMLGFGRFGCGYHVELAEVLDWNEDLRRMNQPIRERRRLSFARKRLFAENMSPEKWKQDVRTLAGPGNIDFLWVFNSGNATAIFTSTVVARKVLEVFNRWKDGRNVYSGVSVTFSSDPCEKELVLVKETSRPGLAKGYVKRSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZN6</accession>
    <name>A0A2I2FZN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701402.1">
        <property type="nucleotide sequence ID" value="XM_024849922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZN6"/>
    <dbReference type="GeneID" id="36557621"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439787"/>
    <dbReference type="OrthoDB" id="3449024at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26722" checksum="3867E5552E9B950E" modified="2018-02-28" version="1">MKVSPSFSKTADLLSIKNWQYLSILSGNLSAICLLLGFVLSGNLPPTKPWWTAERFEEHYHAHIKGTQAATIFLMLGGGFYLPYSAIIAKRMRLIPALDPIIPDLVLACGACGFAAFMLAATFMSVLTFRDYGAETIRLLNDLMWMAAFLPWPAFWVQMWTVSWGIFSDPGPKTVFPTSMGWVNLVTPLGLAFAAGIHIQKEGPMAWNGALSYWVGLAMYGIQVSYDCLVMMKTVREEGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G100</accession>
    <name>A0A2I2G100_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_511301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701862.1">
        <property type="nucleotide sequence ID" value="XM_024854875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G100"/>
    <dbReference type="STRING" id="1392250.A0A2I2G100"/>
    <dbReference type="GeneID" id="36562581"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511301"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="177"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="451" mass="49863" checksum="B621D62870887E97" modified="2018-02-28" version="1">MATRPENVGIKAIEVYFPSRYVSQTELEKYLGVSTGKFTIGLGQTSMSICDDREDLYSLALTTVSSLLKKYTIDPNAIGRLEVGTETLLDKSKSAKSVLMSLFPDNPDIEGIDTYNACYGGTSALINAVNWIESSSWDGRDAIVVAGDISLYDTPAARPTGGAGCVAMLVGADAPVVVEPIRASYMQHVYDFYKGDFGSEYPLVDGHYSNQCYMRALDGCYTRYRERVKQRRGPAAEQEVERDGIDMFDFFVFHAPNTKMVAKAYGRILFNDYRASPDAFASDSIPQEYATIDTDSSLTDKNLEKLFMSLSKAKFTERVHPSLTIPTNCGNSYTGSVWAGLASLLNNVPSETLRGKRVGVYSYGAGLASTLLTLRVRGDTGPMARTLDLHARLAARMEVTPEVYNEMCQLREQAYQQKDYVPQGSVDDLASGTCYLAHVDEKFRRQYEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1B0</accession>
    <name>A0A2I2G1B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_218798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701961.1">
        <property type="nucleotide sequence ID" value="XM_024842849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1B0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1B0"/>
    <dbReference type="GeneID" id="36550548"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_218798"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="385" mass="43317" checksum="A484D8DF52EC6798" modified="2018-02-28" version="1">MATSPFSIMSWEIGLSTPTVPNRGFTLWIWSVIMIILAGIFVLTRLAIRFHNRRLGADDWTIFASMLSSVILTVTECSAVHYGYGKHSSYLTQHNRVIALKWFFAAQVMYKVVIGMTKVSFFCLYLRIFIQPVFRRVCYGGILFILAWSLAYILVTIFQCKPIASFWDKTIQHPHCVDSKSQWLSYAVINILSDVAILALPLYPVSQLKLARAKKLALAFIFGLGLFVCVTSVVRTTTLAQSADDRDPTSGPIPATIWSVIEANAGIICACLPVYKQPLQYLLPRLFGSTHSTGPTSRSKSRRKGQGYASNGDLQDPQDSAWRQLHGSGGSYSNSVSTRGFEMFTMRDHKHNHEITQVVDVKVEYQDDRRRSDASSRPIRDRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1F1</accession>
    <name>A0A2I2G1F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_219527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702007.1">
        <property type="nucleotide sequence ID" value="XM_024842854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1F1"/>
    <dbReference type="GeneID" id="36550553"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_219527"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014189397" description="Secreted protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20137" checksum="709F5C2E57C91CF8" modified="2018-02-28" version="1">MVSSIALAVSLSSTSLSSLVLSLSFFPSLARCLSLDFNLLPTTILDPRFLRLHPARSLQFTLHLSHLGPLSHLDLTHPVAVPVPGWELARSPRGSFLLFSLVGALDPQTVGVLILVRFGRIRSPSTYWLLPVEKPPKGVLDSPPPFHPSLILELPTALFPEPVLAHHPCGVLETEIVAWGFHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1G0</accession>
    <name>A0A2I2G1G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_448500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702012.1">
        <property type="nucleotide sequence ID" value="XM_024850969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1G0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1G0"/>
    <dbReference type="GeneID" id="36558668"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448500"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="531" mass="59163" checksum="AD0A7134499BACAC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1Q0</accession>
    <name>A0A2I2G1Q0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_223326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702102.1">
        <property type="nucleotide sequence ID" value="XM_024842872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1Q0"/>
    <dbReference type="GeneID" id="36550571"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_223326"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="151" mass="17289" checksum="A85796DE976D04F5" modified="2018-02-28" version="1">MMLTPEFQDKEGAQLRSDGESGMVAKFPYFSPGALGLGDFTYSSRYLLSTFSAGGISMDGGLYVCLLVPYDRDFASAREKSPDIAIHPSCMRPVGVIIIIIIFSSFLVLFNLWQRIHPPTAFSFYFFLFVYFFFSLYFYLLGFKHDDNYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G281</accession>
    <name>A0A2I2G281_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SNF2 family helicase/ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_412418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702278.1">
        <property type="nucleotide sequence ID" value="XM_024846931.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G281"/>
    <dbReference type="GeneID" id="36554630"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_412418"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000059">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001870">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1141"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1245"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="741"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1485" mass="168169" checksum="8656B6F43EAA91EB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2I6</accession>
    <name>A0A2I2G2I6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_233739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702369.1">
        <property type="nucleotide sequence ID" value="XM_024842912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2I6"/>
    <dbReference type="GeneID" id="36550611"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_233739"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18993" checksum="769E8045076F378D" modified="2018-02-28" version="1">MRSGTTNSLSFLRPNPSTSRKKKKKKKDSQYCVSGRGKPGISSSTTKSIIIITITRFLFVVCVSIFSSVSLPPFPSFFFFFSFFDQLSRSLLSTAILRLRPFHHQTNPPPLFKLLFYYSFSFLFFHFSSSTRYQVGKALLLTYSSLIRGPVSVCLSRLDSLHFPGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2T0</accession>
    <name>A0A2I2G2T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dimethylallyl tryptophan synthase FgaPT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_438894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702495.1">
        <property type="nucleotide sequence ID" value="XM_024849712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2T0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2T0"/>
    <dbReference type="GeneID" id="36557411"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438894"/>
    <dbReference type="OrthoDB" id="5392033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="442" mass="50299" checksum="BA6947B08E4D647A" modified="2018-02-28" version="1">MALHNVRNASDTSVYKTLSSIFDFADEDQKQWWHSTAPMFADMLQASGYDIHSQYKHLGIYKKYIIPFLGFYPVDDDNRWLSILTRYGLPFELSLNCSDSLVRYTYEPINAATGTAKDPFNTHAIWDSLSKLQLLRKDIDLELFRHFKTDLTLNADESAYLLAHNLAGSEIKTQNKLALDLKHGDFVVKTYIYPALKALVTGRSIQDLMFDSVHRWSHQSPTLLNPLSVLSDYIQSRGPESTITPRLLSCDLIHPSKSRVKIYLLERTVSLPSLEDLWTLGGRLSDPSTTAGLLLVRELWSLLQMPSGVLSYPDPYLPLGSIPNEQLPLMANYTLHPNDPLPQPQVYFTTFGMNDMAVADALVTFFERRGWADMAASYKESLRGYYPHADHNALNYVHAYISFSYRNNRPYMSVYLHSFETGDYAITRLQAPEVNASVEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G316</accession>
    <name>A0A2I2G316_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_438961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702572.1">
        <property type="nucleotide sequence ID" value="XM_024849730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G316"/>
    <dbReference type="STRING" id="1392250.A0A2I2G316"/>
    <dbReference type="GeneID" id="36557429"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438961"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="847"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="904" mass="100716" checksum="6CA02D33119D80D6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G363</accession>
    <name>A0A2I2G363_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_363720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702599.1">
        <property type="nucleotide sequence ID" value="XM_024844601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G363"/>
    <dbReference type="STRING" id="1392250.A0A2I2G363"/>
    <dbReference type="GeneID" id="36552301"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363720"/>
    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="482" mass="53695" checksum="AFC4AFF6DFEBE06A" modified="2018-02-28" version="1">MMVPRAFLFTSVPSQNPSWKHGTRNQPSSKSAADFVTLPDVAGLDFPDKEASEAMHTSPVVIPPKRTSRTSPACPETGNKAPRTPRNSKTARRPSSLASILEATAIPVPRRKWSTRESRKLPRGDHVQDFSRLLMDGVDSKNDQLMEGSGNTALDLLLSPPEENAIGSDCGSETPSFSGRSISLESTPSLDHDIESPSSYSLSLTPSSQRSPSERRYRRLSQCEDCAFDHPLLDTDPSDYEEPIIDHKLTTTNPNPPKPPAPSSRPSASFGSTFKSNLTASLRAIKSAAQTVSTFASPSVQPDDFLTRSLFTITPEMTDDRRPPPMKEPPSPALRRYLNPITASPAEMNAYHDHPHESLDPRKCPVSVQMQTYHRSGRRGSRKSGFHLIGSEGRDRQFHPFDPEIPPMTRQREPRENSDFLRMVVLEMNMRRSGKLRDDIPTRARVCLPPRKGNQNRFMPYDDYEEVEENSIPSRWVGISAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G378</accession>
    <name>A0A2I2G378_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_239165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702630.1">
        <property type="nucleotide sequence ID" value="XM_024842943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G378"/>
    <dbReference type="STRING" id="1392250.A0A2I2G378"/>
    <dbReference type="GeneID" id="36550642"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_239165"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="199" mass="22064" checksum="E176D5577BF80BA3" modified="2018-02-28" version="1">MPSKLPDYPPLEFINSPALLSTVRLLDEWAAPRTQSLPISALKGAVVGIDASHYISQHLLQPSTREPLLVALGGFPFALKTNIERELQTLKELGVGCLFVFNGLGFSTKDQRPAVQPESVRAFEQAWDLYDQQQADQVVDAFSGAGTPRPETLYRFLQRILRAHDIEYMVAPYSAAAQVRWHFLGPTVVSSDRDPSCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G527</accession>
    <name>A0A2I2G527_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_437688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703283.1">
        <property type="nucleotide sequence ID" value="XM_024849423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G527"/>
    <dbReference type="STRING" id="1392250.A0A2I2G527"/>
    <dbReference type="GeneID" id="36557122"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437688"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="11">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB47981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="270" mass="29769" checksum="A7A8D309BBD30A4C" modified="2018-02-28" version="1">MAFPLPRGITPPEISFLAEMEMVTILPRQRLEGLELLGGPVEPLLPPRRATLPLWLALLLKRQRRANILPPPWLHPESLSLILEIETQHQDYQNAFSPPPPLPGQPSLSERGQQRPVATPRYTPDGQRYYPSSPFLPQNVAQDYVPAGEPPALPFHWLEMGTMLLDAASDDLVEPNQVRRLLKELREVRTAKIRSGTDVLDAAATGGGGVALTGVGAMEITEGRGFIAGVVDGLRRIGASKEQARREQMAEDMANGAYDATQDDEDDMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G561</accession>
    <name>A0A2I2G561_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_456688</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703318.1">
        <property type="nucleotide sequence ID" value="XM_024851644.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G561"/>
    <dbReference type="GeneID" id="36559343"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456688"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3200.20:FF:000002">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="16">
        <location>
            <begin position="477"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="788"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="18">
        <location>
            <begin position="1273"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="17">
        <location>
            <begin position="1477"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="15">
        <location>
            <begin position="1762"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="150"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB48016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1974" mass="221048" checksum="EEC70DF756199120" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5B6</accession>
    <name>A0A2I2G5B6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_427211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703371.1">
        <property type="nucleotide sequence ID" value="XM_024847763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5B6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5B6"/>
    <dbReference type="GeneID" id="36555462"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427211"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="273" mass="29656" checksum="7BDA40DE1358E505" modified="2018-02-28" version="1">MQVLLLGGHGKVALRLTPLLLNRAWNVTSVIRNPDHEPEILALGKGTKGKLNVLISSLDDVKSDADAKKILDAVSPDYVVWSAGAGGKGGPERTFAIDERAAKHFLSASFASPRVTKFLMVSWLGSRRVHPSWMADSDWAGVQNVFNNVLPAYAKAKLEADEYMTALAARRKTQVRDGTASPLQAINLRPGTLTDEPATGKVELGTTPGRSKVTREDVAIVADRLLARADTDGWYDLVNGDEPIDEAVERVVRDKVDAVEGEDVDGMVKRFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5D2</accession>
    <name>A0A2I2G5D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_437799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703389.1">
        <property type="nucleotide sequence ID" value="XM_024849448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5D2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5D2"/>
    <dbReference type="GeneID" id="36557147"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437799"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="781" mass="86775" checksum="06B0C1239E80C942" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5P6</accession>
    <name>A0A2I2G5P6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_510869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703504.1">
        <property type="nucleotide sequence ID" value="XM_024854821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5P6"/>
    <dbReference type="GeneID" id="36562527"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510869"/>
    <dbReference type="OrthoDB" id="4463754at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="178" mass="20351" checksum="D152648F949CA68B" modified="2018-02-28" version="1">MSLHGSCSADDDASSIYSRPPHIPKLAQPSACPAPHDLPDIQPLDHQIYLARGSTIALETTRARLQCAKANRRLSLPETIVEKKRQWQCQDHENRFFETCLEILEDLSAVAVDVSQELILQYEFEPETSPEGNARVRRANQRLRSALQQALQREARAEFEWKRQWNVPRIGGPSVRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5R5</accession>
    <name>A0A2I2G5R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_359667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703524.1">
        <property type="nucleotide sequence ID" value="XM_024844368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5R5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5R5"/>
    <dbReference type="GeneID" id="36552068"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359667"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="1">
        <location>
            <begin position="187"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="277" mass="31605" checksum="CC8DA7BDA7E6ED05" modified="2018-02-28" version="1">MSFFNPGTDYILHDCVPIQESKTKGILPWIKNIYRQSRGFEICTFNSSILSSVLKKQSANWPSLAQGYICDVISTVHIFIRKASTVSCRDQKLGENILSLVLDDLIDKSRHALSTTNFLLQIEREGTPMTQNHYLNSNLKKCRQECMSSEAKKSSFSVEYHNGSSGECVRLSDLTQIHHINNLHQTVQDIHDILKSYYKVARKRFIENLCLQAADFYLVTGPEAPMALFSPSWVYNLSSEQLENIVGEESSVRRKRRLLKKQAKGLETGKKICFSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G672</accession>
    <name>A0A2I2G672_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_438034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703679.1">
        <property type="nucleotide sequence ID" value="XM_024849495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G672"/>
    <dbReference type="GeneID" id="36557194"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438034"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF38">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="691" mass="76149" checksum="4929F42D75229B91" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6F7</accession>
    <name>A0A2I2G6F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_386942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703754.1">
        <property type="nucleotide sequence ID" value="XM_024845788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6F7"/>
    <dbReference type="GeneID" id="36553487"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386942"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF201">
        <property type="entry name" value="MFS AFLATOXIN EFFLUX PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="574" mass="61489" checksum="73C47D8C8D4DC0D1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6Z8</accession>
    <name>A0A2I2G6Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_425688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703953.1">
        <property type="nucleotide sequence ID" value="XM_024847660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6Z8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6Z8"/>
    <dbReference type="GeneID" id="36555359"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425688"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="515" mass="56538" checksum="F154EC73D8EB35AA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G718</accession>
    <name>A0A2I2G718_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_166817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703978.1">
        <property type="nucleotide sequence ID" value="XM_024842602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G718"/>
    <dbReference type="GeneID" id="36550300"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_166817"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="170" mass="19600" checksum="7F67F4DEDF585C21" modified="2018-02-28" version="1">MEICFTVTAWRGLWLFLSLFLFLFLVLRSTCPSLRVKVVMVDREDNHRVSLNKLLSYPAGRNIYRRRRDFSGSEAHIPVFVMRHWQNQWLDLHILGLGLVTGLRSHTDIQILAAEEVQAHRLSRMLTRGCPRSCHLIPLSCSPRNDKAVGILDMHEHHVYRETDNGATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7H9</accession>
    <name>A0A2I2G7H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_494363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704141.1">
        <property type="nucleotide sequence ID" value="XM_024854072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7H9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7H9"/>
    <dbReference type="GeneID" id="36561777"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_494363"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="161"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="893" mass="99858" checksum="560E631D0F1862E7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7L4</accession>
    <name>A0A2I2G7L4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Splicing factor, CC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_455693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704174.1">
        <property type="nucleotide sequence ID" value="XM_024851556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7L4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7L4"/>
    <dbReference type="GeneID" id="36559255"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455693"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001012">
        <property type="entry name" value="RNA splicing factor (Pad-1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000876">
        <property type="entry name" value="RNA splicing factor (Pad-1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000172">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="180"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="473"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="570" mass="64458" checksum="21B6A9480536DA17" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7U1</accession>
    <name>A0A2I2G7U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_358487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704237.1">
        <property type="nucleotide sequence ID" value="XM_024844297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7U1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7U1"/>
    <dbReference type="GeneID" id="36551997"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358487"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000395">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000465">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="68"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="514" mass="56654" checksum="AE94E2282A5BB7B0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G844</accession>
    <name>A0A2I2G844_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704362.1">
        <property type="nucleotide sequence ID" value="XM_024853252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G844"/>
    <dbReference type="STRING" id="1392250.A0A2I2G844"/>
    <dbReference type="GeneID" id="36560950"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475386"/>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="217" mass="23354" checksum="7154BA859A73C95D" modified="2018-02-28" version="1">MRTRCHRVLGHPWSHRGGRSTALISEALDSPNPNILPGTRFALRRTFTGLRSPVDYILGMLVLFWWETIDGSHPATSTIGLYVKELSPGSIFLPPVGPGPQALTPGDGVRGFLLWDQVAGYSTVLVVVLLEFRSAFAASRGFRGNKASTLSAWIIGAVGVGLSLVLGPGCACLIGSWTRDEIFSLGIGEALISRRASSSIGFLRTYFGMSVRDPRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G886</accession>
    <name>A0A2I2G886_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_446851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704401.1">
        <property type="nucleotide sequence ID" value="XM_024850834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G886"/>
    <dbReference type="GeneID" id="36558533"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446851"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="558" mass="60340" checksum="EA21105D98B7D6E8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G973</accession>
    <name>A0A2I2G973_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_384319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704739.1">
        <property type="nucleotide sequence ID" value="XM_024845677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G973"/>
    <dbReference type="STRING" id="1392250.A0A2I2G973"/>
    <dbReference type="GeneID" id="36553376"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384319"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000038">
        <property type="entry name" value="DEAH-box RNA helicase (Dhr1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="352"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="552"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1181" mass="130834" checksum="5CB26715F71A8152" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9B9</accession>
    <name>A0A2I2G9B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_408779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704779.1">
        <property type="nucleotide sequence ID" value="XM_024846745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9B9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9B9"/>
    <dbReference type="GeneID" id="36554444"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408779"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="147"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="464" mass="52066" checksum="2EF498197CAFBEE2" modified="2018-02-28" version="1">MGLFSWIRPSGRVSFFHSKDNNLLLAKKAGKSGAKDQITLTDLCRTATPSKCDLNPFLFNGHLQTAWTTVKHDPVPVYYRRRVFEADNPTFSGHFAMDFVVDPYTPPKDGPLMDEERKYTQPSGLPERTSFFSEDEFSALPSEDTKPMLVVLHGLSGGSHEIYLRHIVAPLVADKSWEACVVNSRGCAQTKITTGVLYNARATWDVRQAVKWLRKTFPNRPLFGIGFSLGANILTNYLGEEGEACQLKAAVICASPWNLEISSVNLQSSWIGLEVYSKVMGTSMKQLFEQHVEEVSKNPRIDVETVRKIKYLHEFDRALQCALWGYPTEGAYYRDATSTDSMLNIKIPFFAVQAEDDPIASVNALPFQEIQQTPYGVMMTTSWGGHLGWFELGGDRWFVKPVTNFLNLMAKEVDHETPFVVQNPENVPGHIQSHPGPGKDLDTAPKPHFNPVHRKLGLNLFPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9M1</accession>
    <name>A0A2I2G9M1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704877.1">
        <property type="nucleotide sequence ID" value="XM_024849299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9M1"/>
    <dbReference type="GeneID" id="36556998"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437152"/>
    <dbReference type="OrthoDB" id="4475751at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="159" mass="17538" checksum="9707E8111ACBB948" modified="2018-02-28" version="1">MNAPPSSPESDYQSSWEEEELRRALHNSLPKLAERLHEEIANNPELSARCIDTVGQESKTDTTQSSHVNGLEVIPEERNEQEMACPKAEGGAEPQPIIEMPTEASSQTAPAQHHNQENIPPMRRRVYSTSDTESPEPLLAPPSSPVANYPHHSQANGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9R4</accession>
    <name>A0A2I2G9R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1716-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_437200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704923.1">
        <property type="nucleotide sequence ID" value="XM_024849309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9R4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9R4"/>
    <dbReference type="GeneID" id="36557008"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437200"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000354">
        <property type="entry name" value="DUF1716 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="85"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="583" mass="65491" checksum="99E5599B83E9ABE5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA62</accession>
    <name>A0A2I2GA62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_456291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705060.1">
        <property type="nucleotide sequence ID" value="XM_024851606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA62"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA62"/>
    <dbReference type="GeneID" id="36559305"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456291"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="521" mass="58454" checksum="9A80BFB45FED9843" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAY6</accession>
    <name>A0A2I2GAY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_473599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705327.1">
        <property type="nucleotide sequence ID" value="XM_024853065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAY6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAY6"/>
    <dbReference type="GeneID" id="36560763"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473599"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="632" mass="70931" checksum="1A542A24F8DCCDA6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB73</accession>
    <name>A0A2I2GB73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1960-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_508346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705428.1">
        <property type="nucleotide sequence ID" value="XM_024854562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB73"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB73"/>
    <dbReference type="GeneID" id="36562268"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508346"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF2">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="114" mass="12833" checksum="6251E53D252350F9" modified="2018-02-28" version="1">MRANDTTTKIFYKGTSEDFIVFVDDVKILEQWRQDRSISLANVLNGWKIFVTHKHGAQGVLDGASKSTLQNEFGTTDEDECMTKILEKGEYQVTPGKEHQGDTNHSKGPAMITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBZ2</accession>
    <name>A0A2I2GBZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_473959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705704.1">
        <property type="nucleotide sequence ID" value="XM_024853093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBZ2"/>
    <dbReference type="GeneID" id="36560791"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473959"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014189395" evidence="2">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="217" mass="24346" checksum="BFAE7E06186FF2CC" modified="2018-02-28" version="1">MKLLLSLLLMLAVLSSTLTTRKDVEAPDDLILNATGNEIDMDLSVNTDADDLDGPANTLDARRKKPRPRAKTDGICDTKTDTDTGTCVAKLYGDKRWRSNSFRMKLSPPLILLLTLLSLVLALETQTETSSIKDIDYSLPSNISDPDFDDGQTSQPQTNNIEPRMCIGRCRSVTNDCVWKCEDWSRVVRPCHEYRPCTRDRRHCSVLANAPEWAICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCI4</accession>
    <name>A0A2I2GCI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_435786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705896.1">
        <property type="nucleotide sequence ID" value="XM_024849018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCI4"/>
    <dbReference type="GeneID" id="36556717"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435786"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="52" mass="6034" checksum="1B7AD8429B4C2550" modified="2018-02-28" version="1">MSQHSCWNPTFRVRPRSNFVLARARKLQHAKAVNIRPAGWTSHGEHLPRSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCW7</accession>
    <name>A0A2I2GCW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_406139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706025.1">
        <property type="nucleotide sequence ID" value="XM_024846614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCW7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCW7"/>
    <dbReference type="GeneID" id="36554313"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406139"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1214" mass="133637" checksum="A682E4735723C3DB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCX8</accession>
    <name>A0A2I2GCX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="8">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_508876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706038.1">
        <property type="nucleotide sequence ID" value="XM_024854613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCX8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCX8"/>
    <dbReference type="GeneID" id="36562319"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508876"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="505" mass="57244" checksum="FE92D8A6EB6759FE" modified="2018-02-28" version="1">MGIGYSSPQPPQEEKNPRELTAAMTLRQLVSGNTVDVRFETEEAPPPYSARERTTVLAISQLKDWEDNLLKDPKNRLAISSLARSPYLQVLTNQSALRSDAQVFNVRIPLEGGPITNQRSSGRCWLFASTNVFRVPLMRKYNVPELELSQAYLFYWDKIEKANWFLETIIETVGEDLSGRLVQKLLESPVTDGGQWDMVDNLVQKYGLVPHAIYPDNFNAQNSSKMNWLITAKLREHALVLRRLARSPSVKERETLAETKEAFLQEIHSLVTIMLGPPPNPEQPFVWQYYDANGKSQEIRETPRVFAKQATVQLTRTEVNPKRMLSLVNDPRNEYNRLLTVDKLGNVVEGRPITYINVDMKTLKSAAVAMLRAGHPVFFGCDVGKFSDPAPGVMDTELLDLSLGFNVSLGMNKASRLETGESSMTHAMVLTAVHLEDDKPVRWRVQNSWGENSGDKGWFVMTDRWMDEYTYQVVVDSRFVSKGVRDVLDQTPKVLPRWDPMGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCZ8</accession>
    <name>A0A2I2GCZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_474321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706068.1">
        <property type="nucleotide sequence ID" value="XM_024853122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCZ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCZ8"/>
    <dbReference type="GeneID" id="36560820"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474321"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="331" mass="36334" checksum="956742A5EE996A4D" modified="2018-02-28" version="1">MASTALPPLPTELSSRAVSMVAVSTILETLALVTVTLRFVAKFRTRNIGIDDWLVLLAFVFATGLYITGMLICTIGYAGYHASELRPAIIERFLLLAYIDNIFYALTLPTIKIALLVMYRRIFPTRTFLYAAIAVGLVVLAWMVSVVIAQIFTCSPVQGSWDLAVAGGPQCIDQLKFYYGNSVSNVLTDVAILCLPMPMIWRLNLSRPKKWAVTGAFLAGGFVCISSIVRLSYLSDINNLDITYTLVAVGNWTSIETPLAVICACLPILPSLFRFKDPKTTSYNMSSRGGAGGSTLKSMRNDRSRDYETLDDGTLAESDREEKGVKVHDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDA1</accession>
    <name>A0A2I2GDA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_446038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706099.1">
        <property type="nucleotide sequence ID" value="XM_024850757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDA1"/>
    <dbReference type="GeneID" id="36558456"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446038"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="312"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="684" mass="76864" checksum="3A9767FA03E57C64" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDG7</accession>
    <name>A0A2I2GDG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_425232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706240.1">
        <property type="nucleotide sequence ID" value="XM_024847617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDG7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDG7"/>
    <dbReference type="GeneID" id="36555316"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425232"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="443" mass="49871" checksum="0C8B7969BD4AA50B" modified="2018-02-28" version="1">MLFDELPNELLLSIAERLTSAKQISALMRTNHHFYALLYRLLYIYNIEECRCSALNWSIDRENMKPIETLLDLIFSTKKYSRWIPQIQGALGEAAACGHDEIVEMFLKTEGFDVNGPMDESPLYLACMFSNNARTVELLLATGQIDPNIPKRAWALREWQTPLFAAVDHQNDKVVEALLASEKVDPNVPNEDSRTPLFLAAQEGYAKSVEMLLATGRIVAMKSDPLQDTPLIAAAAEGRVAIVRRLLKEDFVDVNERGRRGRTPLIAAVREFQWEVVEELLATSGVDTGLRDNSGRRALTHAVGRGCWQIVRDLVTMEGDEWNTGDPGFPTQFMRAVEFGHLDIIQFMLSMGRFDVNKLDVNGLSPLGAAVNYEHTHVVRSLLTVNRVWLNQPQSGQTPARIARRRGLPEIADLIESCIPACYRNRDDIDIKVGGPYWLPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDH9</accession>
    <name>A0A2I2GDH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_446076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706169.1">
        <property type="nucleotide sequence ID" value="XM_024850762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDH9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDH9"/>
    <dbReference type="GeneID" id="36558461"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446076"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="526" mass="60007" checksum="7E12549FED84A3B8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEZ2</accession>
    <name>A0A2I2GEZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_79995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706752.1">
        <property type="nucleotide sequence ID" value="XM_024855389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEZ2"/>
    <dbReference type="GeneID" id="36563096"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_79995"/>
    <dbReference type="OrthoDB" id="3449024at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="254" mass="28037" checksum="1D0DC1EE2E3D3D13" modified="2018-02-28" version="1">MMLNLKQVLLRESEISSSTQRHPLSKITATRAQLLCWPVSTLFLLAILPASVNLPPVNPVLGPRAVAQHYRDHYQGFRAGVAFVHLSAVFYPFYAIAVSTVLSHIPNVNPVLVMAQAAAGIAIGVTFMTLGVLFGTITFRLDRDPPLIQLISDLAWLYFTLLSAMLIVQNILVGILIHSDCRQRPILPVWLAWAHWSTPVGCIGIWVTHCFQRGPFAWNGGLSFWSPVVGYIAQALVNTVLFWIAAGEIEEVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF37</accession>
    <name>A0A2I2GF37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_443697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706797.1">
        <property type="nucleotide sequence ID" value="XM_024850574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF37"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF37"/>
    <dbReference type="GeneID" id="36558273"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443697"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000786">
        <property type="entry name" value="Protein kinase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="54"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB51495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="382" mass="44112" checksum="663308796D66BEFC" modified="2018-02-28" version="1">MSLLRFMRSAPYKVKPVPAYALRRSQPIEEERIPHYDPKHFYPMQLHTTLANRYQVAAKLGWGTSSTVWLAKDLHQWCWLPSRYVAIKVNTNNYASQECAEKELRVTEHITRANPADQGRYFVRTLLDSFTLQGPHGHHICMVFDPFYEPLWMLKERFEGRVFPPDALRTIVRMIVMGLHYLHTQARVIHTAKADLKSDNIIMALRDQSLLDTSLGRPVITDFGLSVYGEKAPYTHPIQPNGFQAPEVILRASWDYSVDIWNLGALVWELLCGSGPFDYATSSSDSSYSEKKHLASIISSIGPPPTDMLKRERRAPRYFSDDGQFKFPDLITQTRGLDQLLTVIDGEEKRMFVKFITRLLQWQPKDRATVEELLSDPWLQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF50</accession>
    <name>A0A2I2GF50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_348571</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706812.1">
        <property type="nucleotide sequence ID" value="XM_024843687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF50"/>
    <dbReference type="GeneID" id="36551387"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348571"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="20"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB51510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="518" mass="55281" checksum="73E004ADD440B460" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF64</accession>
    <name>A0A2I2GF64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706826.1">
        <property type="nucleotide sequence ID" value="XM_024852841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF64"/>
    <dbReference type="GeneID" id="36560539"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471458"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="152" mass="16360" checksum="6A68F7EB7422EE63" modified="2018-02-28" version="1">MASSTNPLLNGDIQSTAPNSPSKASTPRSLENNTTQELQPQPHESPTIWHLFDDEHFPNLLKTILDLSELPNGAFPSDSEDDSEDEDFEPSSDEGSSEFDSEFDLDDDDLDSIPSSSDDLDIDIFGMDARDVAAGIGSRDKGAVAGSGETRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF81</accession>
    <name>A0A2I2GF81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S41 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_351552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706840.1">
        <property type="nucleotide sequence ID" value="XM_024843874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF81"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF81"/>
    <dbReference type="GeneID" id="36551574"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351552"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="119"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="2">
        <location>
            <begin position="307"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="650" mass="72038" checksum="1B49D4E7F5B286DF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF91</accession>
    <name>A0A2I2GF91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_422556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706850.1">
        <property type="nucleotide sequence ID" value="XM_024847443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF91"/>
    <dbReference type="GeneID" id="36555142"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422556"/>
    <dbReference type="OrthoDB" id="5366688at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20238" checksum="69A32B0FDAA293B8" modified="2018-02-28" version="1">MPKYGALGATFQIARIVQACCLIAIIGLTANFIAEIVDNDATPPGIFIGTITITCIATIYCIITTILFLDDILPFLASAIADSLVLIAVIVVAVIIGKPLSYLQCEEIAKVASEGSSAYAFATHLDSYLKSLNGKVEYGSLIGASKAVCLEAKSIWGLSIGLCIMFFFSGVCCVCLWKQKRAANAGAEKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFV1</accession>
    <name>A0A2I2GFV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZZ type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_433586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707019.1">
        <property type="nucleotide sequence ID" value="XM_024848527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFV1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFV1"/>
    <dbReference type="GeneID" id="36556226"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433586"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02341">
        <property type="entry name" value="ZZ_ZZZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041981">
        <property type="entry name" value="ZZZ3_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="377"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="705"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="778"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="818" mass="89824" checksum="3533CDEF0E920FC2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGD6</accession>
    <name>A0A2I2GGD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_433824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707222.1">
        <property type="nucleotide sequence ID" value="XM_024848584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGD6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGD6"/>
    <dbReference type="GeneID" id="36556283"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433824"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000231">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000215">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="63"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="218"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB51920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1123" mass="129636" checksum="30CD052C3D9BB3E7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGM4</accession>
    <name>A0A2I2GGM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_506926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707335.1">
        <property type="nucleotide sequence ID" value="XM_024854427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGM4"/>
    <dbReference type="GeneID" id="36562133"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506926"/>
    <dbReference type="OrthoDB" id="5213892at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="529" mass="57960" checksum="9AFD4BD6515EA832" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGN4</accession>
    <name>A0A2I2GGN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_506929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707338.1">
        <property type="nucleotide sequence ID" value="XM_024854428.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GGN4"/>
    <dbReference type="GeneID" id="36562134"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506929"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000030">
        <property type="entry name" value="Histone acetylase complex subunit Paf400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2618"/>
            <end position="3173"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3497"/>
            <end position="3822"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3819"/>
            <end position="3851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1990"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3181"/>
            <end position="3322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2012"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3193"/>
            <end position="3203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3223"/>
            <end position="3276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3284"/>
            <end position="3305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="3851" mass="439954" checksum="38F34332897E46A2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH66</accession>
    <name>A0A2I2GH66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_507035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707479.1">
        <property type="nucleotide sequence ID" value="XM_024854439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH66"/>
    <dbReference type="GeneID" id="36562145"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507035"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="529" mass="58518" checksum="5691ABF8ABA906B1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHM7</accession>
    <name>A0A2I2GHM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_348738</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707682.1">
        <property type="nucleotide sequence ID" value="XM_024843696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHM7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHM7"/>
    <dbReference type="GeneID" id="36551396"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348738"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="414"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="483"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="798"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="877"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="832"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB52380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="949" mass="106420" checksum="F476D92B0BFCB87B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHT1</accession>
    <name>A0A2I2GHT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="11">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lipoate synthase</fullName>
            <shortName evidence="11">LS</shortName>
            <shortName evidence="11">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_434160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707699.1">
        <property type="nucleotide sequence ID" value="XM_024848658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHT1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHT1"/>
    <dbReference type="GeneID" id="36556357"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434160"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="148"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB52397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="420" mass="45745" checksum="0D97EE7C27BA7B50" modified="2018-02-28" version="1">MAASTTRLRSLYSSTSRAVSHPGAVAPIACRSYATTDPSPSATGAPGTTPRRRTTFKDKLNAGPSFSDFVSGGADDAPLDPSEAYALKTAMVGPAGRKKEMTRLPSWLKTPIPDSKNYQRLKKDLRGLNLHTVCEEARCPNISDCWGGSDKSAATATIMLMGDTCTRGCRFCSVKTNRAPAPLDPHEPENTAEAISRWGLGYIVMTSVDRDDLADGGARHFAETVIRTKQKAPNILVECLTGDYSGDTDMVGLVARSGLDVYAHNVETVEALTPHVRDRRATFQQSIRVLDAAKKAQPSLITKTSLMLGLGETEEQLWDALRQLRAVNVDVVTFGQYMRPTKRHMAVHEYVTPDQFELWRQRALDMGFLYCASGPLVRSSYKAGEAFIENVLKKRRAAATGAPGEQTVSDTKVAVDEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIY8</accession>
    <name>A0A2I2GIY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708141.1">
        <property type="nucleotide sequence ID" value="XM_024848741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIY8"/>
    <dbReference type="GeneID" id="36556440"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434565"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014135221" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="88" mass="9697" checksum="40133F855FF04DF4" modified="2018-02-28" version="1">MAVWLCGCVACLSRQCSATLSAGKRITSVRMLAVATGLGRCSVEYISRSGGIRRWTVPISDSDWTRAHLDKNRWSCSVLVVGRLQIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ34</accession>
    <name>A0A2I2GJ34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_379129</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708192.1">
        <property type="nucleotide sequence ID" value="XM_024845474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ34"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ34"/>
    <dbReference type="GeneID" id="36553173"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379129"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF365">
        <property type="entry name" value="ENDOCHITINASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="56"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB52890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="449" mass="49399" checksum="4D1031D7B0B13BC8" modified="2018-02-28" version="1">MAVPPLIHYCVLLGVVIFFSFRYFGSNPTLIPLHPSSPTTSVATPENSSEPTMSSMKSVAYFVNWAIYGRNHHPQDVPADKLTHVLYAFANVRPESGEVYMSDSWSDIEKHYPTDSWNDVGKNVYGCVKQLYLLKKQNRKLKVLLSIGGWTYSSNFAQPASTDAGRTKFAETATRLVLDLGFDGFDVDWEYPKDEAQAQNFVLLLQKCRETLDRAAGGNRKFLLTIACPAGPENYTKLKLAQMTPYLDFYNLMAYDYAGSWDSKAGHQANINFSSSNAASTPFSTVQALNYYTQAGQVPSSKIVLGMPLYGRAFTNTDGPGTPFSGVGQGSWENGVWDYKALPRPGAAEQYDAQTGASWSYDPAARVMVSYDNVRMAEQKVNFIKQNNLGGGMWWETSGDRGGRAANKGEGSLIGAFVEGVGGPGALDQSANVLDYPESKYDNMRAKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJE1</accession>
    <name>A0A2I2GJE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adipose-regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_403728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708305.1">
        <property type="nucleotide sequence ID" value="XM_024846490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJE1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJE1"/>
    <dbReference type="GeneID" id="36554189"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403728"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="374" mass="41897" checksum="234169EBE02D654D" modified="2018-02-28" version="1">MDTESGSTDGEINEQPTLLSRAINTSAAFIQPLISKRAQKAYLGTLLLFLSAICMVVVSTIAYGIFYYKIIPQVGLERVVHLQFGDGHPWGTTSLGSGLISLQPYDVSVELELPRTPSNLGTGNFMVDLTLIPGPSSPILDSANASTDPFLRSRRPAILTYASPLIDTASKLSFMPFYVLGWQRESEKLQVPMMERIQFARGRRNIPDRLRLEIHSQQQMQIYKAKVAFRARFTGMRWLMYNWRITSFFVFTFMFWSTSMISASIVWIVLATFANSGTDGKVTVKKEDRDETRIKQEPLEESTSPLESSLDTSNDQPERRVKKEKEYQVESQADDESEGSPDKQTSGAGTGLESSGAQGVQRRRRHTSGDDDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK21</accession>
    <name>A0A2I2GK21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_454352</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708511.1">
        <property type="nucleotide sequence ID" value="XM_024851427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK21"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK21"/>
    <dbReference type="GeneID" id="36559126"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454352"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB53209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="572" mass="64696" checksum="451F4FEF669D0CA7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK45</accession>
    <name>A0A2I2GK45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator of proteases prtT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Zn(2)-C6 zinc finger-containing protein prtT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_404248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prtT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708560.1">
        <property type="nucleotide sequence ID" value="XM_024846513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK45"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK45"/>
    <dbReference type="GeneID" id="36554212"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404248"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB53258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="774" mass="85368" checksum="840167FD903B215B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKB2</accession>
    <name>A0A2I2GKB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_454420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708613.1">
        <property type="nucleotide sequence ID" value="XM_024851432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKB2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKB2"/>
    <dbReference type="GeneID" id="36559131"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454420"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="400"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="600" mass="67742" checksum="F835F2CDAF723579" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL53</accession>
    <name>A0A2I2GL53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADC synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_473437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708881.1">
        <property type="nucleotide sequence ID" value="XM_024853038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL53"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL53"/>
    <dbReference type="GeneID" id="36560736"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473437"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019996">
        <property type="entry name" value="Salicylate_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03494">
        <property type="entry name" value="salicyl_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF48">
        <property type="entry name" value="ISOCHORISMATE SYNTHASE MENF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="5">
        <location>
            <begin position="176"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB53579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="451" mass="48766" checksum="3F2189D5BB0DFF92" modified="2018-02-28" version="1">MPSHIISFDLDFAENVTLERVAMVLSRYKECEHYAYERADTWSLGLGTHASFMIDAKGEIATITTGARREEHPVGDSLAQAARDFLSQHAQPDHKVFGQVGFNYAAHTQGMPFKPGSCPLLSLLVPRVEVLFHRDQITLTGPHDTELKELSTLIMGDAALEPHPGSTIDTGDPAGEYVSQVQRAQADIAGGKYTKVVPSRAVRLSTRVDMAATLLCGRQANDPARSFSLSQGGFQATGFSPELVMSVREGIVATEPLAGTRSRLGSAAEVEKLTQELTHDPKEIMEHVMSVKEAMEELNRLCVSGTVTTDDFMSVRPRGSVQHLGSRVSGTLTADKDPWDALGVTFPSITASGIPKRAALEGIQRLENRPRELYSGAVLMLDGPDSFEASLVLRTVFQDPHRAWIQAGAGVIAQSSPDRELTETREKLASIAPFVVTEATPVGLCSCGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLA1</accession>
    <name>A0A2I2GLA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_451698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708955.1">
        <property type="nucleotide sequence ID" value="XM_024851210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLA1"/>
    <dbReference type="GeneID" id="36558909"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451698"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="541" mass="58963" checksum="1BBD09B0BAC88ED1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLD5</accession>
    <name>A0A2I2GLD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FUN14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_504626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708994.1">
        <property type="nucleotide sequence ID" value="XM_024854214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLD5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLD5"/>
    <dbReference type="GeneID" id="36561920"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504626"/>
    <dbReference type="OrthoDB" id="3990500at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014147634" description="FUN14-domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17348" checksum="5E496D33269B122C" modified="2018-02-28" version="1">MSLLMSRTSAILGVGVGLGLSLSPLSPFRSTPIQCQYAAPYPRATESAESGWAIDGQDPLLRKQGATGPGSSIFTASNMRQVSLGSVLGLVAGVGLRAFSKALVVLLGMGVVLVEWAAAKGYNILPLQKMQRYVKGVDLQKAVSRQIPFKLSFGATMTLAAFAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLQ4</accession>
    <name>A0A2I2GLQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_460155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709107.1">
        <property type="nucleotide sequence ID" value="XM_024851917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLQ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLQ4"/>
    <dbReference type="GeneID" id="36559615"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460155"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="508"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1018" mass="114148" checksum="DA309BD40E59CCA7" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN00</accession>
    <name>A0A2I2GN00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM5</name>
        <name evidence="13" type="ORF">P170DRAFT_431876</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN00"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN00"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431876"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB54243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="83" mass="9009" checksum="AB953E61916E172F" modified="2018-02-28" version="1">MASQLLPLELIDKCVGSKIWVIMKNDKEFSGTLLGFDDYVNMVLEDVTEFDYTGSQVKLPKILLNGNNVCMLIPGGEGPAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GND0</accession>
    <name>A0A2I2GND0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_469847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709678.1">
        <property type="nucleotide sequence ID" value="XM_024852680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GND0"/>
    <dbReference type="GeneID" id="36560378"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469847"/>
    <dbReference type="OrthoDB" id="4364135at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014124058" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="61" mass="6570" checksum="D9692DF4564A408B" modified="2018-02-28" version="1">MNLSAVVTISLASLVLAYPIPFQHRRALNPFALTEKLMPHSGIPQTVGKTGLGYGLKDDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNL5</accession>
    <name>A0A2I2GNL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_469921</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709758.1">
        <property type="nucleotide sequence ID" value="XM_024852686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNL5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNL5"/>
    <dbReference type="GeneID" id="36560384"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469921"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000432">
        <property type="entry name" value="SWR1-complex protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Myb-like" evidence="14">
        <location>
            <begin position="148"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="499"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB54456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="599" mass="66705" checksum="9449E78CF9821D7E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNU1</accession>
    <name>A0A2I2GNU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="10">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="10">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MEF1</name>
        <name evidence="12" type="ORF">P170DRAFT_373776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNU1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_373776"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="101"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="186"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="240"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB54547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="803" mass="89116" checksum="79124F08FB3A997B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP00</accession>
    <name>A0A2I2GP00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_21371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709904.1">
        <property type="nucleotide sequence ID" value="XM_024842825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP00"/>
    <dbReference type="GeneID" id="36550524"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_21371"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="99" mass="11245" checksum="0FCBF259836DC1BE" modified="2018-02-28" version="1">MREARASHLHWARRRTRMLKQATADPRRIAGRALALQMPRSVRAIVTSKAAMQCHVGQERKVVSLVCPVDFVSPRHLTRGIQILGDAARVARQCTWYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPG7</accession>
    <name>A0A2I2GPG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_421425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710073.1">
        <property type="nucleotide sequence ID" value="XM_024847360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPG7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPG7"/>
    <dbReference type="GeneID" id="36555059"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421425"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="127" mass="14043" checksum="B08A8AD25A726C79" modified="2018-02-28" version="1">MAMPDQFTQPFGASKGPPSLHGSGKNEHHTSSIWQAAIDRYYAELRRGGVKGPAIDHDLWRIHSPDDLFQQSNALSPADSRGCDDPLGRDEWSGGGCNMGLDQIDHEEARRIEKDSLGYGPICILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQA2</accession>
    <name>A0A2I2GQA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_421664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710346.1">
        <property type="nucleotide sequence ID" value="XM_024847381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQA2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQA2"/>
    <dbReference type="GeneID" id="36555080"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421664"/>
    <dbReference type="OrthoDB" id="5404323at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="574" mass="62989" checksum="87737B101039E2FB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQS5</accession>
    <name>A0A2I2GQS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide exchange factor Vps9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_432771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710538.1">
        <property type="nucleotide sequence ID" value="XM_024848335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQS5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQS5"/>
    <dbReference type="GeneID" id="36556034"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432771"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14369">
        <property type="entry name" value="CUE_VPS9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041804">
        <property type="entry name" value="Vps9_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="424"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="728"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="85090" checksum="05046362C4E6846F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR79</accession>
    <name>A0A2I2GR79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_461247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710656.1">
        <property type="nucleotide sequence ID" value="XM_024852017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR79"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR79"/>
    <dbReference type="GeneID" id="36559715"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461247"/>
    <dbReference type="OrthoDB" id="3921198at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1780.10:FF:000006">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF15">
        <property type="entry name" value="PRNA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130084" checksum="958402203FA39040" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRF5</accession>
    <name>A0A2I2GRF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_470849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710736.1">
        <property type="nucleotide sequence ID" value="XM_024852790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRF5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRF5"/>
    <dbReference type="GeneID" id="36560488"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470849"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000072">
        <property type="entry name" value="Cysteine proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="142"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="832" mass="95645" checksum="E190413164C86890" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRP1</accession>
    <name>A0A2I2GRP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_461392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710854.1">
        <property type="nucleotide sequence ID" value="XM_024852031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRP1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRP1"/>
    <dbReference type="GeneID" id="36559729"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461392"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11653">
        <property type="entry name" value="rap1_RCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="10">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="11">
        <location>
            <begin position="476"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="568" mass="63713" checksum="5D761E7EFB05AD57" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS77</accession>
    <name>A0A2I2GS77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_471136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711036.1">
        <property type="nucleotide sequence ID" value="XM_024852810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS77"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS77"/>
    <dbReference type="GeneID" id="36560508"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471136"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000009">
        <property type="entry name" value="Putative Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="83"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="385" mass="43495" checksum="C7909361D1C1F227" modified="2018-02-28" version="1">MALTQPPVPVDIFPDGLKTTGQHPPLSEHIHPFDKFPKEISGPTLWKAEDYREHPEKWTHRFSAEEIDELSGAADAFLQNKIPLTGISKSNFPLPNLSNHLETLRRDLIDGKGFILFKGFPVEKWGNHKSAVAYMGLGTYLGYFVSQNSRGHVLGHVKDLGEDSTKIDSVRIYRTNARQYFHADDSDIVGLLCIARALEGGESDIVSSHHVYNTLAKERPDVLKTLTEPIWYFDRKGETSKGQDEYIKTSVVYLERGENARVYTKWDPYYVRSLTRFSDAGIIPPLSPAQLDALEVLEATCNRLSLHMILEVGDIQFVSNSHVLHARTAYTDHAPPAPRRHLMRLWLATPEHEGGWKLPFWDSNEKKRGGIQVDDQPPVAPLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS87</accession>
    <name>A0A2I2GS87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_471139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711040.1">
        <property type="nucleotide sequence ID" value="XM_024852811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS87"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS87"/>
    <dbReference type="GeneID" id="36560509"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471139"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="554" mass="61941" checksum="8536CE49F85E0256" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSK3</accession>
    <name>A0A2I2GSK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_51650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711164.1">
        <property type="nucleotide sequence ID" value="XM_024855245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSK3"/>
    <dbReference type="GeneID" id="36562951"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_51650"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="313"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="702" mass="78090" checksum="8E1BF96A934058E1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQ89</accession>
    <name>A0A2I2FQ89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_315483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000027">
        <property type="protein sequence ID" value="PLB42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQ89"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_315483"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="82" mass="9129" checksum="C3E6322308A34040" modified="2018-02-28" version="1" fragment="single">MSFHNVKLESSSTGSSFPADSAKPVPFAVVSLDNDEAFGYLKRVIVTPAVYPRLVEFLHFDIQSTGQKSHCVNTTFWPSQCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR48</accession>
    <name>A0A2I2FR48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_418806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698416.1">
        <property type="nucleotide sequence ID" value="XM_024847241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR48"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR48"/>
    <dbReference type="GeneID" id="36554940"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418806"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="56"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="202"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB43114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="464" mass="48762" checksum="A03138266B3EF18A" modified="2018-02-28" version="1">MMLSRSTFSRNAPRALQQCSGAAASSRRGMASAVTPGLQYDVSESAGVKVANREVAGPTGTLALVAKAGPRYQPFPGFADALEYFAFKTTLKRSALRITREVELLGGEVSSSHTRENIVLKAKFLSNDLPYFAELLAEVASQTKFAAHELDEVVLKLLKYRQQALSANPEALAVDAAHALAFHRGLGETITPSLAVPFEKYLSAEALLEYAQQAYAKSNIALVGSGPNSADLSKWVGEFFKELPSTGSASQYQVKPSSASKYYGGEQRISSKAGNAVVIAFPGSSAFGTSGYKPEASVLAALLGGESTIKWTPGFSLLSQATQGFSQVRASTQNHTYSDAGLFTVTLSGKADKVASASKNTVDFLKKAAAGEIASEDIKKATALAKFRALESAQTLETGLEASGSALVHGGKPYQISEIAQGIDSVTEAQVKEAAKSFLSGKASVAAVGDLFQLPYAEDLGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRS3</accession>
    <name>A0A2I2FRS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_441738</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698608.1">
        <property type="nucleotide sequence ID" value="XM_024850389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRS3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRS3"/>
    <dbReference type="GeneID" id="36558088"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441738"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000008">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB43306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="90" mass="10518" checksum="585B98A69F7D8E82" modified="2018-02-28" version="1">MEGLSASEQREFASRMERKQLKEFMTMYSKLVQRCFDDCVNDFTTKSLVNREEGCVMRCVDKYLKGSARLNERFQEQNAAMMQSGQMPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSQ8</accession>
    <name>A0A2I2FSQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_441116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698959.1">
        <property type="nucleotide sequence ID" value="XM_024850233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSQ8"/>
    <dbReference type="GeneID" id="36557932"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441116"/>
    <dbReference type="OrthoDB" id="4412761at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="229" mass="25241" checksum="65BB17CC68291766" modified="2018-02-28" version="1">MDTSTPTATHGMSINVYGRGDATLGDGPSHMGIAVYEFGSPTCKMHHIRNPNDTDFIYDPRTQPLEDPVLRGRCEIATFSNDSKERVIRLLTDFGNDESNIPEFGIGNCQDWVAAAALMLEQAGLLKQGEGAFWRGMVNSSADEMRDSCLRTGRTWVAGPESTFEGEPDARFNDKTTVQVGKLAQNPMFQARMQSLLGNRQGQQSSSQETSERPFYISSPFFSRANVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTI0</accession>
    <name>A0A2I2FTI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_441377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699241.1">
        <property type="nucleotide sequence ID" value="XM_024850293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTI0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTI0"/>
    <dbReference type="GeneID" id="36557992"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441377"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="15"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="369" mass="41309" checksum="83936D4594A3DAEC" modified="2018-02-28" version="1">MAEKEVSVPLPLATIKVEALVVMKIIKHCSQTFPTTATGSIVGMDAASGLEVTNCFPFPVVEVPAESHFDNAAANPAAAAPRAKANAAYQAEMIRMLREVNVDANNVGWYTSANMGNFVNMNVIENQFFYQKEMNERTVALVHDVSRSAQGSLSLRAFRLSPKFMTAFKENKFTSDELQKSNLRFQDIFVELPVEIHNSHLITSFLHQLQCPSQSAPADLPPSLAALESGPFIKDNVLAPNFDNLALSIDPFLEKNCDLLLDSIETHHTETNNYQYYQRSLAREQTKITNWQNKRKQENASRAALKQPLLPEDEWQRLFKLPQEPSRLETMLNSRQVEQYARQVDSFVSATTGKMFAVKGNLLPGETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU86</accession>
    <name>A0A2I2FU86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_430081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699473.1">
        <property type="nucleotide sequence ID" value="XM_024847928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU86"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU86"/>
    <dbReference type="GeneID" id="36555627"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430081"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="26100" checksum="7DF713453F63D425" modified="2018-02-28" version="1">MSAKPIAVVAGVGPGTGASIARKFGKSYSIAVLARNPANFEPLVNEIKSNGSDAIGISTDLTSSASVQSAFDQITQKYPDAPLAAAVFNPGGGFVRKPFLELTEEEFVQGYESQGKGAFNFAKSSLPLLLKAKHLPHPPTLIFTGATASVKGSATFSAFATGKFALRALAQSLAREFGPQGVHVAHVIVDGVIDIPRTKEWKFEHEDAKLDPDAIADSYWHLHTQPRTTFGFELDLRPYVEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUB2</accession>
    <name>A0A2I2FUB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_450379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699506.1">
        <property type="nucleotide sequence ID" value="XM_024851121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUB2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUB2"/>
    <dbReference type="GeneID" id="36558820"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450379"/>
    <dbReference type="OrthoDB" id="5273647at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="357" mass="39911" checksum="44E35202671D7F35" modified="2018-02-28" version="1">MDSHALYARGIDSGSRQATVFGVGIGFMAFITVVIALRVYARAVILRAMGADDVFMVIGTILTFGLSISSIIAAYYGVGRHIDDISESDFTPMLKAVWATRIVYIAGLLFVRLSLLWFYLRLDQRPLMRWSVYTLIFINVGLSVSSIIVVIVSCVPVSKFWDLEGTAPGKCMNPDAQQIFYEANGILNIILDIFIYIVPMPTLWSVKISNVHPAGCVRYDFVKKLAHNKDQYYYLADSLNWCSIECYVAIFCGSAPALQVIIKTYAPRVLGTSNAQKYDSQKHTPGQGYSNRMSTMYRMSRHRRLETDRGGSQDAIVPGSAPENGIVMKTDIRMEVTDRDSEEGKRMDTGFHVDFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUJ0</accession>
    <name>A0A2I2FUJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_440621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699617.1">
        <property type="nucleotide sequence ID" value="XM_024850122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUJ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUJ0"/>
    <dbReference type="GeneID" id="36557821"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440621"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="428"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB44315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="651" mass="71532" checksum="667A86145B39E11F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUS4</accession>
    <name>A0A2I2FUS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_513591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699692.1">
        <property type="nucleotide sequence ID" value="XM_024855127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUS4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUS4"/>
    <dbReference type="GeneID" id="36562833"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513591"/>
    <dbReference type="OrthoDB" id="441890at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1308" evidence="2">
        <location>
            <begin position="327"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="541" mass="59721" checksum="6038ED8D78B7FEA5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV20</accession>
    <name>A0A2I2FV20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024850146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV20"/>
    <dbReference type="GeneID" id="36557845"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440729"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="58" mass="6350" checksum="6E8D9AB6BACE523F" modified="2018-02-28" version="1">MHTASDPVGPPDCLPGLDSTSPRTPPNRKTQRTNGYPSTLSISKAPNQRSPEFPRRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWA3</accession>
    <name>A0A2I2FWA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_479449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700210.1">
        <property type="nucleotide sequence ID" value="XM_024853676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWA3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWA3"/>
    <dbReference type="GeneID" id="36561374"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479449"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="320" mass="35835" checksum="3564CC076CA7881C" modified="2018-02-28" version="1">MDDTERDAITEWIEGVATDDLSPSGSTRSDITANDRSRQPSSSPTRTKSNLASATPKIRYLHESADPGSELARELLALLTAEDNDGWEPETHEIDKVSAASHKCDAQLRSESSWVIEVVRPLLQCAIGTLPLECWSVQTETVDPKYQPRYTARDTYSRKIDLVVGFPTDEWPDEYERMAALSSDRCFSHITHPHTGARFLGPGFEIKASDGNLVEAQVQLGVWMAGLITWMWERRCKGALPPPVVGCISIGERWDFYIIYGVEIVGSARPEVRVWGPLSDLDARTGSRKATTLLAKRLRQVMKYTESQYFQQLLKAFTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX02</accession>
    <name>A0A2I2FX02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_274320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700473.1">
        <property type="nucleotide sequence ID" value="XM_024843159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX02"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX02"/>
    <dbReference type="GeneID" id="36550858"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_274320"/>
    <dbReference type="OrthoDB" id="5597238at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014185318" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="18428" checksum="26B9AD50A2FAF57E" modified="2018-02-28" version="1">MKLNLIALTALLGLAVAQSSTSTGEASATTSLSPEASCAKKCSDNDLCCVASCYKVPCPSDSQANDTVSCVAACPQGTGSPSDTDRYAKCQSSCYSSHFFPATKLSDSGSSATHASSNSDSKTTGTSDDDSSSATGSSTGHHSGSGSSASASATGTSSGSEASETANAAALKLGVSTAGVIGLVLGALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXM5</accession>
    <name>A0A2I2FXM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_366669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700638.1">
        <property type="nucleotide sequence ID" value="XM_024844767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXM5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXM5"/>
    <dbReference type="GeneID" id="36552467"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366669"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="435"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="544" mass="59635" checksum="027F5D61CE4D639B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXP2</accession>
    <name>A0A2I2FXP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_439161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700695.1">
        <property type="nucleotide sequence ID" value="XM_024849779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXP2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXP2"/>
    <dbReference type="GeneID" id="36557478"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439161"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="447" mass="49837" checksum="E795F283BA66F903" modified="2018-02-28" version="1">MASANSDLPPEPASLSASLYDVLTDLHQNQYPHVPNPPSCKKRASVALVLRIRPTYRHWPTPETSSLPVLDHTASVHDRLTPFFAQDWVQNGDPEVLFIKRASRAGDRWTGHVALPGGKRDPEDVDDKAAAIREASEEVGLDLTTEDCIHVGNLPERVVTTSWGSVPLMVLCPFIFLMTRSDSPPLRLQPTEVASTHWVPLRALLSPSLRTVENVDMSQRLSNMGGIIPRFVYRCLLGMMQFSAIRLRPTESLQSNTTPGFLPDDFRTSPSVSPMRRWTTWLSGNQSDPVKQERPLLLWGLTLGILADFLDMLPPHTAVKMWKYPTFTTPDLWLIVSVLTYRLRKRNQLQVQSGARPSNTAVDGQTAALPVAPTTDDNNEVGIGGLGVGRYYGPSDRVPDGSKYAVGIMLKGYYSRLRVAVSIFLAWRAVVGSVAAIYTWRYFRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXU8</accession>
    <name>A0A2I2FXU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_244319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700756.1">
        <property type="nucleotide sequence ID" value="XM_024842973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXU8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXU8"/>
    <dbReference type="GeneID" id="36550672"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_244319"/>
    <dbReference type="OrthoDB" id="4508018at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="226" mass="23999" checksum="737CE7AFBA193488" modified="2018-02-28" version="1">MGIFSWLCCIPSSPSPPPLSASPQPRPHSTTTTASNAPNTETGYTSPTGLPAYTPRPVSIHEKTLELHMRDPPISSTSAPDQHQHSYPDEKAPYRYSIDHPAPGNRPEDLSSDVSSAISFTSSYGNTSTATRDTPPPPYSPRDGSPVPSRSQSVSSGSGPGPGMVSMGWAVGTGTGSGGGGPAQIMQIAQPRPVFQRQETLVRSLVARRSVEEQVDRRRSCEGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY20</accession>
    <name>A0A2I2FY20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_413804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700824.1">
        <property type="nucleotide sequence ID" value="XM_024846994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY20"/>
    <dbReference type="STRING" id="1392250.A0A2I2FY20"/>
    <dbReference type="GeneID" id="36554693"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413804"/>
    <dbReference type="OrthoDB" id="2103031at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35336" checksum="B5E87DE824DB0725" modified="2018-02-28" version="1">MGWFWGKSEDPVKKLDPGLREYLEHEAPKKYVPTTPEIPKPVDSQSQPSQAPPTAESDESSQPALPNASLYPDGRYAHLWKTYKPPASEETQKGAERVIEKYKQRGDTVHRAAMENCALEHEDLTYCFQTGTWSKRIKSRMSMCHEENHTFSRCFTTQAKFLQALGYASAFNWDPEREERIQMHADKLYHEMIGYEKQVEEAKAAGQAPPPITSLFNPQARQEKAEASADALEIPGGEAIPAGFKPSKPLENLTPHERELELRSHYAQMEQQKLYAQEALPFVKAQDDARNKRRDKAVSWFGETVGKWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY78</accession>
    <name>A0A2I2FY78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative plasma membrane low affinity zinc ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_363820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700891.1">
        <property type="nucleotide sequence ID" value="XM_024844611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY78"/>
    <dbReference type="STRING" id="1392250.A0A2I2FY78"/>
    <dbReference type="GeneID" id="36552311"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363820"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="354" mass="38523" checksum="7F363D7EAEA6C03A" modified="2018-02-28" version="1">MSLLHSLLARDGDSGAAPACETGNEYDGRMGLRISSIFVIMVGSMFGAVFPVLAGSYRQSKMFGWAFFIAKYFGSGVIIATAFVHLLGPAEEALTNECLTGPITEYSWVEGIILMTIVVLFFVELMVMRYARFGQNHSHDEFDHSHSHSGESVQHSAEVADSKGHMPGEDHLGHSREHKDLEAAKTAALEEYMAQLTSIFILEFGIIFHSVFIGLTLAVSGEEFVTLYIVLVFHQTFEGLGLGSRLAEVPWPRSKRITPYLLGIGFGLSTPIAIAIGLGVRNAYPPEGRTTLIVNGVFDSISAGILIYTALVELMAHEFMFSTSMKKAPIQHVLAAFGLLCLGALLMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYN2</accession>
    <name>A0A2I2FYN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_249457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700968.1">
        <property type="nucleotide sequence ID" value="XM_024843013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYN2"/>
    <dbReference type="GeneID" id="36550712"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_249457"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="116" mass="12924" checksum="805503B838FA6F87" modified="2018-02-28" version="1">MRRDGGEKVGITPSVIVDLRAGDRWGINHRLVSSRTPESKLVEIGFEIRSGEKITMQSPSPAEVCDGRARGRMTTSDYPASRPAFCFDFLRVFAFSALPLGFWLLSISLLFLLSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ42</accession>
    <name>A0A2I2FZ42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_458057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701118.1">
        <property type="nucleotide sequence ID" value="XM_024851763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ42"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ42"/>
    <dbReference type="GeneID" id="36559462"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458057"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="476" mass="52733" checksum="4586723C45665939" modified="2018-02-28" version="1">MDVTKCGLGPLSPEFHEPSDIDGVRQDLFTKGIAFIEGCDEDSLVEVANQLGDINRPRNEKLQGSGVSHIRFAPNLTGKGYSSEELFFHTDRSGWQSPPGILMSTLKSRSESGGESLLADSHRILEIIKQEDEELYKLVTSAKHTSFYSDDGVFVPRAIFDTEDQIFRFRFDDSIQLSASMVSGFARLQETIYKNAFVVSLQPGQGYILNNHRFLHGRASFSGSRELLRVLVTPHPPRREMVVLFDIDGTLCRSEDLSIDAYFSCVSAVVGKTITHANTPVSLHGRTDLSLLHAILDFHAVEDKAQATERFFSLHPQYLEDSHAKGFPVLPCPGVKEILGWLTEYQRDRCDPPLRIGLLTGNSRPNALLKIRAAGFDTSIFDLEISSFGDVHPDRQSLFQDSLQRLQTRYGRGVAAHDIVIVGDTPLDIECAKQTGCSVVAVATGSYKVDDLALLEPDFCCSLLTEAKDYLALKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZD4</accession>
    <name>A0A2I2FZD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_257966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701289.1">
        <property type="nucleotide sequence ID" value="XM_024843060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZD4"/>
    <dbReference type="GeneID" id="36550759"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_257966"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="159" mass="18451" checksum="FBE4EB323666FE03" modified="2018-02-28" version="1">MLAETRPSHAYDANDPSVIVHCMSLIETPEARGYRFRSGRRHRYMQSGWVSTGPWLHRAISTLRNPSELHTEAYGGAWRLESWGSRTDPHTATLSALFLREIFHHFQLGMLHNRFDGLTWLVRRVCFRSIAVRWKAVGVAPTHYLRLSAPRTLHRLHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZM7</accession>
    <name>A0A2I2FZM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_439781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701394.1">
        <property type="nucleotide sequence ID" value="XM_024849919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZM7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZM7"/>
    <dbReference type="GeneID" id="36557618"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439781"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="959" mass="106758" checksum="1AF6BE084813B5FB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZT8</accession>
    <name>A0A2I2FZT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_364067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701452.1">
        <property type="nucleotide sequence ID" value="XM_024844626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZT8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZT8"/>
    <dbReference type="GeneID" id="36552326"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364067"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF30">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_7G06030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="88"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="376" mass="42937" checksum="B3CF45088410A5C0" modified="2018-02-28" version="1">MPSSAPVIRPKKTQPVNAHKEDEPISYDINIPYVDVNKETHARTRYPEYLPTWDKIWFDPLTPFTYEDPALRVKDKSKRNLLGPDTKVTEIQPRMGTVVEGVQLNKLTDAAKDELALLIAERKVVAFPEQDLIDAGPEAQEAFMRHFGKPNYQPVSGSVRGHPGFHIIHRDGNREEISRFLEQRTTTTLWHQDVSYEIQPPGYVMLGLLEGPEVGGDTVFAATDMAYKRLSPTFTSWLDTLRVTHSSAKMINHARSTGGLVRKDPVDTTHPLVRVHPVTGEKCLFINGEFITRIQGLKEPEQRWLVDFLMQHIIGGHDFQARVRWQPRTIVMFDNRCTLHSAIVDYLDDDNGAKLRHIFRLTALGEKPIPVYDQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZZ7</accession>
    <name>A0A2I2FZZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative siderochrome-iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_439859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701507.1">
        <property type="nucleotide sequence ID" value="XM_024849931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZZ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZZ7"/>
    <dbReference type="GeneID" id="36557630"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439859"/>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="571" mass="62144" checksum="3E6FA0A12455DF6C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0L5</accession>
    <name>A0A2I2G0L5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cytochrome P450 oxidoreductase GliC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_411644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701723.1">
        <property type="nucleotide sequence ID" value="XM_024846906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0L5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0L5"/>
    <dbReference type="GeneID" id="36554605"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411644"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20615">
        <property type="entry name" value="CYP_GliC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="520" mass="58702" checksum="D065A53403B99973" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Q5</accession>
    <name>A0A2I2G0Q5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_427781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701764.1">
        <property type="nucleotide sequence ID" value="XM_024847797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Q5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0Q5"/>
    <dbReference type="GeneID" id="36555496"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427781"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF113">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="410" mass="45021" checksum="41A43801ECED02DB" modified="2018-02-28" version="1">MTSADDDRSLEVKAVAAVFMSVACVTVMLRCYVRGWVVKGFGWDDGTMVFAMLQLFHVMFSACMIGGSIYGTGRRFADLTAHERVTAMKYWWLCEIAYCFASIFCKISVCIFLMRITVKPIHLWILYTVMVLTVLAGLVFMFLMLLQCKPLAYFWTRTAFDPDIDGHCISIDIIIAMTYVYSAFAAICDFTVGLLPIFLVRKLHMKKQTKIAVVCILSMACIASSAVIIRIPYVKTFADPDFLYATVEIAIWSNIETGLGITAGSLATLRPLLRHWLGSRADPSYSSPFPGPSASRRAAAGASRDRPFPLGSLDNDVQSRLRPDKLAVTVTTIQSQSQHDPEQSWRGGPSSPNSSEERLTIAQPSPIAVHDGGGEMGLSIHQTFEVTQTSTGGLPGGGSGEERVGVREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G192</accession>
    <name>A0A2I2G192_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_427945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701946.1">
        <property type="nucleotide sequence ID" value="XM_024847813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G192"/>
    <dbReference type="GeneID" id="36555512"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427945"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="191" mass="21411" checksum="07E2C53C135B77BF" modified="2018-02-28" version="1">MAAQRAPEEDASREASRGNALAMLGGIQTKSESKSKREECSKRKKGKRIIIIKWWWFLSGGIGKINCDGARESSARFGLVWGSWRDWKRKPDHRCGHWSLVQEWLPHCQRQGSEGRGFSDLLLGFFSSAAGLGDARSNQPRQARTHRIVFLAKPMQASVPAATVRDVVRIVTFTFLPVTTDQEARSSARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G199</accession>
    <name>A0A2I2G199_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_438364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aromatic compound metabolism; naphthalene degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701957.1">
        <property type="nucleotide sequence ID" value="XM_024849585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G199"/>
    <dbReference type="STRING" id="1392250.A0A2I2G199"/>
    <dbReference type="GeneID" id="36557284"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438364"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="497" mass="53303" checksum="E71C20AB0692471A" modified="2018-02-28" version="1">MTTPIPHISNWIDGTHTTATTTSIPVLNPATEAPLATIDATSHSQITSLITTSLQTFTTSPWCRPDASTTRFTVLTTAARLLRARIPEFITLETQQTGRPIREMRAQLARVPEWLEYFGSVARVHEGRVPPFKGPVVNTLTRLPLGVVAQITPYNHPLLIATKKIAAALAAGNVVIVKPSERAPLSVLRLGELFKEAGLPDGVLQIVSGYGYETGKWLCEDPRLAKIDLTGGLGTYQAIAGAAARNLIPITAELGGKAPVCFLDVDVEVGVKAALFAAFIASGQTCVTGSRLLVHKDVYEGFKGLLETRVRALRVGDPFDGRTQIGAVISQEAVERCAKFVERAVDGGGRVLCGGKAMKVDGKGFFFEPTVIETTADSDLACNEVFGPVIALLKCESEEEIVRVANGTSFALGASVWSNDFAQAHRVAAQIEAGIVWINGHHLNDPSSPWGGFKESGVGKENGMEAYESYTKVKSTVMNYGVPPAWFDDEPEGARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1B4</accession>
    <name>A0A2I2G1B4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_438384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701975.1">
        <property type="nucleotide sequence ID" value="XM_024849590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1B4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1B4"/>
    <dbReference type="GeneID" id="36557289"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438384"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="69"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="425"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="83372" checksum="4DEBAABB332180A7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1C0</accession>
    <name>A0A2I2G1C0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_511364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701971.1">
        <property type="nucleotide sequence ID" value="XM_024854883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1C0"/>
    <dbReference type="GeneID" id="36562589"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511364"/>
    <dbReference type="OrthoDB" id="3204049at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="488" mass="56698" checksum="255857FADCF58073" modified="2018-02-28" version="1">MAHQAHNIPWGLLASNLEWKSPTPWNNFATNLYPRMKPNQAKDLTHFVNAFVQNLAEHAACERKKYPAHYEPPQPSDVILSDATVRKILPTVRRWRNEDFPLSCRHEMCECDPIPYEERLMSAFLRPPHSRSEHWEYPHMNDAAFFNFQILQTLLLYGEMDPILRVCAHPDSHDLLKFWYVGDFWEGPGDLGWDKICQHMTKVYICLNIAYCFPETWDFASGRTEENDYRNAKFYQKTLITAAGVTPWDVRTYPHTQFFGMEESCGRLDLRTNTGKSEHWLLDEGYNAMMRNKGKRQCARASLWDFKYKAENNPVGFYGRVPIHEFLALWMPEGWGYAPSGDEVDEVRAVLCQRGLPVELALDVMDFAGYRPPRGRLGVPHDPMHPGNREALGQYLKYCWQTMVRCYTLATEMGMDPVGSMNAGEGMNWKNFVADAIVDLFGHHKDGRKHHWTEVEFVEKLPRVWYKKESVSDDDAPDGWRGPFTTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1J8</accession>
    <name>A0A2I2G1J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_221441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702051.1">
        <property type="nucleotide sequence ID" value="XM_024842862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1J8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1J8"/>
    <dbReference type="GeneID" id="36550561"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_221441"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="543" mass="58650" checksum="F021311823F83AA8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Q5</accession>
    <name>A0A2I2G2Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_448824</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702449.1">
        <property type="nucleotide sequence ID" value="XM_024850997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Q5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2Q5"/>
    <dbReference type="GeneID" id="36558696"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448824"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014171182" description="Inactive metallocarboxypeptidase ECM14" evidence="18">
        <location>
            <begin position="24"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="19">
        <location>
            <begin position="200"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="540"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB47147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="593" mass="66209" checksum="85A00C67D2BAF368" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Q7</accession>
    <name>A0A2I2G2Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">6-phosphofructokinase</fullName>
            <ecNumber evidence="4 15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_438874</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4 15"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702466.1">
        <property type="nucleotide sequence ID" value="XM_024849705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Q7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2Q7"/>
    <dbReference type="GeneID" id="36557404"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438874"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="392"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="600"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB47164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="775" mass="83792" checksum="CAA0D48AECE9E13B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3U3</accession>
    <name>A0A2I2G3U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-protein ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_385271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702825.1">
        <property type="nucleotide sequence ID" value="XM_024845716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3U3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3U3"/>
    <dbReference type="GeneID" id="36553415"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385271"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="106470" checksum="5FCA2E657EE001F6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3V7</accession>
    <name>A0A2I2G3V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_385326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702851.1">
        <property type="nucleotide sequence ID" value="XM_024845722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3V7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3V7"/>
    <dbReference type="GeneID" id="36553421"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385326"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="11">
        <location>
            <begin position="179"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="417"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB47549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="515" mass="56097" checksum="692095226E96C536" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G482</accession>
    <name>A0A2I2G482_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_465284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702984.1">
        <property type="nucleotide sequence ID" value="XM_024852311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G482"/>
    <dbReference type="GeneID" id="36560009"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465284"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="163" mass="18029" checksum="9A1B5ED77C9A1733" modified="2018-02-28" version="1">MSLILYHPTNPTRIPLKPVHLPGILRAAAIIRQSVSNNRVLDSAESIPGSNSKHPDTVVTSYTREWVLLGSVTGESRNKSARSGKKPENISRLTVAIRQSTNAAESSISHSSNKERKISLLLQKRLSYTLVVRFSFGDWTGQTFSGDMVPSLDQAKPQKEARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4L2</accession>
    <name>A0A2I2G4L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_437546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703110.1">
        <property type="nucleotide sequence ID" value="XM_024849391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4L2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4L2"/>
    <dbReference type="GeneID" id="36557090"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437546"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="226" mass="24035" checksum="F414485DD73B76B7" modified="2018-02-28" version="1">MMSARVARAGLRATQQFSVPRTAALNGLRTYATPAQEVKPPVSLFGVDGTYATALYTASSKAAALDQTAKALTTLGETLKADRKLTGIISAPTLTVGDKQQIVQELQKLSGDKGDVVKNFLEALAENNRLGLLEGITEKFATLMGAHRGEIELNITSAQELDNKTINRLEKAVAKSEFSQGKKLKVVSKVNPDLVGGLVVEIGDRTIDLSVSSKIAKLNKALTDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4T3</accession>
    <name>A0A2I2G4T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_456591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703184.1">
        <property type="nucleotide sequence ID" value="XM_024851637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4T3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4T3"/>
    <dbReference type="GeneID" id="36559336"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456591"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="630" mass="69035" checksum="EA3F2F1D25C5E4B9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G505</accession>
    <name>A0A2I2G505_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_476585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703235.1">
        <property type="nucleotide sequence ID" value="XM_024853364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G505"/>
    <dbReference type="GeneID" id="36561062"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476585"/>
    <dbReference type="OrthoDB" id="4415250at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="207" mass="22886" checksum="5E21BF9715C07308" modified="2018-02-28" version="1">MEGGARAPVDSQNAPAFLDLEELDTLLKSYPNLSADEWARVKSHTDELEPLKDPGIVLLEHFMTPRSEIELTLENAHKLAAGIIRIWPDLQLRNIAPDKLLRLRRGIIDSQCPVGWSRMYGFLVLGCASSLDSPDLGRLVSSLLKTVDRIQGQSPVRAHRILPRINLLLEKLSATISMSTKMENDSAAAARLLESPALNPILRGIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G542</accession>
    <name>A0A2I2G542_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_386115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703304.1">
        <property type="nucleotide sequence ID" value="XM_024845756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G542"/>
    <dbReference type="STRING" id="1392250.A0A2I2G542"/>
    <dbReference type="GeneID" id="36553455"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386115"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="237"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="726" mass="77903" checksum="6E024501CCAF6C1C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5D4</accession>
    <name>A0A2I2G5D4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_510784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703394.1">
        <property type="nucleotide sequence ID" value="XM_024854813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5D4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5D4"/>
    <dbReference type="GeneID" id="36562519"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510784"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17639">
        <property type="entry name" value="LC_FACS_euk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="108"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="701" mass="77333" checksum="D5CC93905F85F9C6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5E4</accession>
    <name>A0A2I2G5E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_386350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703404.1">
        <property type="nucleotide sequence ID" value="XM_024845766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5E4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5E4"/>
    <dbReference type="GeneID" id="36553465"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386350"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="487" mass="51781" checksum="C1C87424E696EE98" modified="2018-02-28" version="1">MSASKAESQKIFEKLKLKPANKVCFDCSSKNPTWSSVPFGIYLCLDCSSNHRNLGVHISFVRSTNLDQWQWEQLRLMKVGGNESATKYFQSHGGSAALASKDAKVKYTCNAAVKYKDELKRRAAQDAQQYPGEVEITDVPAGVSSNGSSTPAADEDDFFSSWDKPSIKRPSNPPSRTGTPPVVSRNGTPFLNTAAAANANGARSKSPLSASDKESSPAPAAIRASTSVRKATSAGPAKKTSVLGAKKAPKLGAKKVGGAEIIDFDEAERKAKEEAERIEKLGYDPEAEKAEADAKNKTANTGATAIASPTPISPSKGGFGATKSSQERNSNDVERLGMGIGRLGFGQTVSAKPAAPKKLGFGSVGPTRTAADDEEIKQNKDRFGTQKGISSDEFFGREKFDPNAQAEAKERLRNFDGATAISSNSYFGRPEDDLPAADDTYGDLEGAAKDFVRRFGITAGDDLENLSQIVGDGAVKLQGAIRSYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5H0</accession>
    <name>A0A2I2G5H0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703431.1">
        <property type="nucleotide sequence ID" value="XM_024853378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5H0"/>
    <dbReference type="GeneID" id="36561076"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476774"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9111" checksum="5049E993165EEB19" modified="2018-02-28" version="1">MFNFAWFKSSKEEAPAATWNANTLTMEQPSSPAAPQQQQQQQQVVTDQPSSQEPMQMTLRGGGSGGVCCGICAGLACFECCEICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5T3</accession>
    <name>A0A2I2G5T3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_360210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703532.1">
        <property type="nucleotide sequence ID" value="XM_024844402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5T3"/>
    <dbReference type="GeneID" id="36552102"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360210"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="508" mass="56425" checksum="AB41BBA0ECA47522" modified="2018-02-28" version="1">MTDPGPKASEIEQREFSSSTNDIVKPVSRAPQYVRDLSPTERQRAEKRLVRKVDLRLMIVTFVMYVMNYLDRNNIAAARLAGLEEDLNLKGNQFQVTVSILFIGYLLMQVPSNMILNKMGRPSIYLPSCMVVWGTISTATAATHNYAGLLVCRFFLGFVEAAYFPGCLYLLSGWYTRNELVKRTALLYSGSVISGAFSGLIAAGITGNMNGARGLAAWRWLYIIEGVITIFIAILAFFIIPDLPRTTRWLSEEERQLAAWRLEEDIGEDDWVDSQDQSMFHGAKLAFLDYKLWLLLGTIYGSTSSGTVTNFFPTVMKGLGKGNVETLLLTTPPYLIGAVVMLANAWHADKTGERYFHIVISPVVGLVSFILAVATTSFAARYVAMCLMIGGIYAGYVVALGYISNVLPRPASKRAAALALINCLSNVCQVYAPYLYPNEDGPRYLKAFVHNMAMSVMTILFGTILRIVLVRLNKKLDEEEGVDILEQSQGQGPDGEPVVVRRGFRYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5Z6</accession>
    <name>A0A2I2G5Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="19">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_437975</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="19"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703603.1">
        <property type="nucleotide sequence ID" value="XM_024849485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5Z6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5Z6"/>
    <dbReference type="GeneID" id="36557184"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437975"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060205">
        <property type="term" value="C:cytoplasmic vesicle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014139372" description="alpha-1,2-Mannosidase" evidence="20">
        <location>
            <begin position="21"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB48301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="508" mass="56457" checksum="11408E62D7746B7C" modified="2018-02-28" version="1">MHLPSLLPLTALAFVTPSLAYPQHNHEQPLLKPEKSQSRADTIKEAFVHAWEGYYKHAFPNDELHPISNGFGNSRNGWGASAVDALSTAIIMGNATIVDQILDHVAKVDYSKTTSMVSLFETTIRYLGGMISGYDLLKGPASDLIKDKSKVETLLTQSKNLADILKFAFDTPSGVPYNNVNITSHDNDHATTNGLAVTGTLVLEWTRLSDLTGNTEYAKLSQKAQSYLLDPQPQEAEPFPGLVGSHIDIRTGKFSDAQVSWNGGADSFYEYLIKMYVYDPKRFGKYKERWVAAAESSIKHLASHPEPRPDLTFLASYNNGNLGLSSQHLTCFDGGSFLLGGTVLDRDDFIKFGLDLVNGCHTTYNETLTGIGPETFSWNPNNVPDSQKALYERAGFYIGSSVYILRPEVIESFYYAWRVTGEEKYREWVWNAFVAVNKYCRTDSGFAGLKNVNAENGGGKDDNQESFIFAEVLKYVYLAHSDDEAWQVQKGQGNKFVYNTEAHPVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G684</accession>
    <name>A0A2I2G684_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_211498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703693.1">
        <property type="nucleotide sequence ID" value="XM_024842817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G684"/>
    <dbReference type="STRING" id="1392250.A0A2I2G684"/>
    <dbReference type="GeneID" id="36550516"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_211498"/>
    <dbReference type="OrthoDB" id="5281164at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="20403" checksum="C9ED5EEC2A6BB2A3" modified="2018-02-28" version="1">MDSYSPAQDPPRQPTGTFNLTGLPTELHMQISSYLSYPDALALKHTSQHFYSLVYTGVHLKVDWLVERFERKLECPMEKCSFRTDESFCNWRIRRIMDRRRRHLECQRGRGGCFVIPGETCQVGLVSAWLKGRGRRLKVVRYVGNEVLIHALIFLCIHLIWNFFLRQFLLPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6F8</accession>
    <name>A0A2I2G6F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_456961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703763.1">
        <property type="nucleotide sequence ID" value="XM_024851668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6F8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6F8"/>
    <dbReference type="GeneID" id="36559367"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456961"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="170"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="456" mass="50528" checksum="1FD2C7E5708B3196" modified="2018-02-28" version="1">MKAQRQTLRRIGVLPQPLQPQWRVYSRSQSTKAVLPPHSLLPTKMLLRSLLVATISSHRALLTPALKVLSMIAHPRIGLLSVEKNPILRAFLKTSFYNHFCAGENNAEVSATIGRIKNMGMKGVILTYAREIGSDNSSISTPEGTSEQREKGTALDKPSSSQDPQIEAWCVGVMETVEMIGEHDFLALKFTGAGAAAADALQTGGPLPSQMMNALKAICNRAVERKARIFIDAEQQSVQDGIDQVALDLMRLFNRDGRATVYNTYQAYLKSTPTTLHAHMDCARKENFTLGVKLVRGAYINSEPRHLINDTKANTDTQYDSIAADLLKREYGAGPFPSVELFLATHNKESVLKAHGLYQARIQSGEPTVKVQYGQLLGMADEVSCRMLQIKEEGNGDESLVAPEVYKCLSWGTLGDCLSYLLRRAVENRDAVSRTTAEYVALKTEAKRRFMMYFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6G0</accession>
    <name>A0A2I2G6G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_448158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703767.1">
        <property type="nucleotide sequence ID" value="XM_024850947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6G0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6G0"/>
    <dbReference type="GeneID" id="36558646"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448158"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF6">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36720" checksum="AD9824E39C15A341" modified="2018-02-28" version="1">MTPRPLYIAALDTDVPCPPVYAQRGLYSSQFRVLLRAAAERLQERFSPTGQQSIDVQVTAFDVVGGSFPPFECLRTDSSFSTEQVHHRPTPGPIDAILVTGAAAAAYNDVPWIHALRTYIQKVYTEYPLVKIFGSCFGHQLIAQALLGDETGSICERKAVSVERSEGYEMGVHTISLHPDFQSRFSPLDPFSWERPFRIQLIHGDAVFPTQGRAAERPPTRVCLPEPWINIGSSAACQIQGLYKPGQVLTLQGHFEFDAFATIALCQEFGRRHHWSPEVLASCIEEIERSPEDDSRAAAEVVLLFLAGRDCAMDGGPTKCERTNNLGRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6I2</accession>
    <name>A0A2I2G6I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_511058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703780.1">
        <property type="nucleotide sequence ID" value="XM_024854847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6I2"/>
    <dbReference type="GeneID" id="36562553"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511058"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32908" checksum="519AC07BE62F1707" modified="2018-02-28" version="1">MESLSSLVSSAWGSLGFWKAAAIFFALLNLKTFPMVWHIRVYRYFFKHGYLITPAVEQPARPSTELLDPVSIYSRAPIMELDFNMHKSNSTYFSDLDVSRTALMSNIVVKGAALLEKQLAANGKRGPLGFILGSVYTSFKREIPAYMKYEVKSHVASYDNKWIYIVTYFLKPGKKGRVLDAEALKKKLYAVSISRYVLKKGRYTVPPKDAFQAAGYTPLLDVVAANGNGHATGAENGVADGDITQRKGAEAKDGEWERLKEEIDRGLAVVEPFINQEEKLMEEYVHKMSLPGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G746</accession>
    <name>A0A2I2G746_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704004.1">
        <property type="nucleotide sequence ID" value="XM_024853214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G746"/>
    <dbReference type="GeneID" id="36560912"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475050"/>
    <dbReference type="OrthoDB" id="10559467at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="425" mass="48300" checksum="8AE016DB25F3A468" modified="2018-02-28" version="1">MSAEQSQARQTASNSTEPATNFSDWADIESICNLIKIELDQLEDLGLPSTQIFQKGVPSLDQHVETIKQGLYSDREIDSMMSTEITNDIQLLDIGGQNSQEPEVEVVYPMLTDHSQSAQQAELEYPLLTMEQIQEIESLDWDVINSYRNQIDSYAGQEPDALAIDRLCVKQAENSCPYGELYKFVGDVDEPDGTNPASMSIVNFRLPADFLEMVPFNRNKYFADHLVIEFVRNGVLQLKSVDIRNKTFSVEIDLQDRNQLAKVDTISVYLQSQGEVQKPLVSFFNTYKIHPRPLPKLSDPVIKLMFELDVSVDPTNVQEVLWGIKRALNWRIETGLWDSRTPLCHCAWSYFQISMPPCASDYQALYCIAEMLIIPLLFDTEGHYGFTKFPFTIQNPVTFAGGIHLRGPVKIERIHRGPVIYPSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G772</accession>
    <name>A0A2I2G772_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_407397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704022.1">
        <property type="nucleotide sequence ID" value="XM_024846681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G772"/>
    <dbReference type="STRING" id="1392250.A0A2I2G772"/>
    <dbReference type="GeneID" id="36554380"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407397"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="345" mass="39568" checksum="560856472D4D6655" modified="2018-02-28" version="1">MDFTTNRAEFDAVLQYLIDEMTGYFKQIGLPSDAIKHVQESFDTNVRNGKLFRGLSVPETGYILLERPLSVDEFHDLSILGWLVEMLQAYLLVLDDIIDGSITRRNQICWYRRPEVGLTAINDACLIKSAVFFLLKNHFRTHPSYLQMLESFNEITILTESGQEADAIASREKCPGNWTLDQYRHITLLKGGYYCFYLSVLLGLQYLNLATPLNMREAEAILIPLGQFYQFQNDFLDIFGHTSRTGKVGTDIQANKCSWVVIQALRICQDDRHDTMLEKYGRPEHKAAAEVDEIFQSLPLARLYEREAEEVLGGLRKKITNVNESEGLRKGIFELLTSMVHRLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7A9</accession>
    <name>A0A2I2G7A9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704064.1">
        <property type="nucleotide sequence ID" value="XM_024853223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7A9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7A9"/>
    <dbReference type="GeneID" id="36560921"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475104"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF2">
        <property type="entry name" value="SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="222"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="533" mass="60455" checksum="8E8BC7C1903862EA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Q7</accession>
    <name>A0A2I2G7Q7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_464496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704216.1">
        <property type="nucleotide sequence ID" value="XM_024852252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Q7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7Q7"/>
    <dbReference type="GeneID" id="36559950"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464496"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="349" mass="38718" checksum="E338A0EBA9EC3E63" modified="2018-02-28" version="1">MEKRKNWGDINVHLPGLTLLLPVISASIKQHIPRLYHLTDQSAESNDYSHELNTEVVSKEIETRPLSSSSSESDLESVFSDTPRPTTSSSTCTGQEPDLFAECMMDNNDAFISEEIVDRGIAHPAKSKYEAISGLRWNRVVPALGFLQNACYEAQQPTCDGRLVRSMYINALGYLLDAIPKDITSEESAKIRLNLPVKIRASMPATADLAPCATCGSNQRTNTRQIHRSYLHRLLAASILQLFIILHFLMPYIKIMIRKIYQFERSHHITERTIAATASAADSLTKNGLHLGFDILSMRDGQAGITVSNLLTWWVEGIAGGICEGVGEGMTILGVIRPNQELERTPVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8B8</accession>
    <name>A0A2I2G8B8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper/iron-regulated glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_358547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704428.1">
        <property type="nucleotide sequence ID" value="XM_024844302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8B8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8B8"/>
    <dbReference type="GeneID" id="36552002"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358547"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="244" mass="27453" checksum="F347A2E486F2DA99" modified="2018-02-28" version="1">MANQSPLKIAILINTPPGNEFRHDVRNSYTEIFRIMAPKAHLRFFDPVFANEFPDPKMNPYDFLVLSGGKADASSEEPWVLGVLHFVRRTVCETTKTKLLGICWGHQAIARALGGEVQPVPTGPIAAVQDIRLTYAGRKFFGYAAEAGYYTAPEFHIREAAKPAPGFIHLAENHECFLNATGTVLTFQAHPEVQSGLARKMLLEEDDVYNGNSTKEQLEEELRKLMQPTDGIRLMERVVQWIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Z1</accession>
    <name>A0A2I2G9Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_358738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704987.1">
        <property type="nucleotide sequence ID" value="XM_024844313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Z1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Z1"/>
    <dbReference type="GeneID" id="36552013"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358738"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="519" mass="57394" checksum="7457D0B4BD5A9A47" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAC2</accession>
    <name>A0A2I2GAC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_409423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705115.1">
        <property type="nucleotide sequence ID" value="XM_024846782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAC2"/>
    <dbReference type="GeneID" id="36554481"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409423"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="351" mass="39805" checksum="EB43F67DC1897C8E" modified="2018-02-28" version="1">MPLRRSHKKSHHGCLQCKQRRIKCDEARPYCGPCHRKQLACAFQSLLHQWHVATALSLAHEEQLADVVRVAVPREALAYPFLMHSVLAVSALHLSYTGPSERCQSYKEAAIRHNNLSLTLCTPLLSNVTPENCHALFAFSCLTAVFAFGVQGREGLPSAQGLVDVVEVFKMVRGVASVVQQARAWIEQGGMSQLLKIGKLRKRAAGTIYDRELCSHLETFIEEQLRPREPCMHQTINNNNVNAVLLQSANRLLHVLNMYMTMEDPNAILAWPVLLDAQYLDLLLQVEPTALIILAYYGTALHLLFDNWWLDGWGQFIMNLASMRRGSVGDWRISWLVDIIQRDKEFRLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAF3</accession>
    <name>A0A2I2GAF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Longevity assurance proteins LAG1/LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_473445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705158.1">
        <property type="nucleotide sequence ID" value="XM_024853040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAF3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAF3"/>
    <dbReference type="GeneID" id="36560738"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473445"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="147"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="469" mass="53246" checksum="FB1F78A74FDFE7E9" modified="2018-02-28" version="1">MKQVSNGLNSNCPQPIHLQSLGLADQSPCKHIPLASSEGIAGQGIQTAYIRFLQRPGRWLLDNQIGFSSVCIAVLLFTHLCVPEARFHASKFLFISHHSASRRTYAVGGDDFYFTGFCIVLFTGLRAALMKYILTPLARHLGISRTKDVNRFAEQAWLLCYYSVLWTLGMYIYCTSSYFLNLKELWTEWPTRELPGINKIYILGQGAFWLQQLLVIHIEQRRKDHWQMLAHHTITIILISTSYVWHLTRVANLILILMDVVDILFSLAKCLKYLGLFTLCDVMFGVFMLSWFLARHVFYLLTMWSIYTHMVDIIPVGCFHGSQDNLTGPTPLPERGWSQILDPFRNPSGTICFSRGVNWAFLGALGFLQLLNLAWLVMIVRVAVRVFKGRGAEDVRSEDEDEDEKPVQTGECDDASSRARAIGVAATDLKSPMRMTSVKRTAHSTSVGLPRRSDQKQLLGRLGCERQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB33</accession>
    <name>A0A2I2GB33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_404847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705394.1">
        <property type="nucleotide sequence ID" value="XM_024846553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB33"/>
    <dbReference type="GeneID" id="36554252"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404847"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="563" mass="60339" checksum="DE70DC57301D8240" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB49</accession>
    <name>A0A2I2GB49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_473660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705387.1">
        <property type="nucleotide sequence ID" value="XM_024853072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB49"/>
    <dbReference type="GeneID" id="36560770"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473660"/>
    <dbReference type="OrthoDB" id="4316405at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="175" mass="20225" checksum="DC7818C8A6DF3121" modified="2018-02-28" version="1">MDKEKDAAVSREDGRYQRLFSALNDQLVKWRSDEKSYAKIKGYDTMMKPLTNRVVQLRIEDGQRFMLQYFSRDDGLGLGLKDKLVKYKEDPRVPGGPDYERVDLGKTWESHEEDVKKAISKAMNGNVQIKSFKDFEAWVTDYGNPDGRFAEATKANPTHFRTLQMWKAIGDSKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB50</accession>
    <name>A0A2I2GB50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="1">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_445490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705411.1">
        <property type="nucleotide sequence ID" value="XM_024850717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB50"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB50"/>
    <dbReference type="GeneID" id="36558416"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445490"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="323" mass="36155" checksum="885EE4B62FFF0B5B" modified="2018-02-28" version="1">MLHQIPSLGFGTFQVDLQADPQQAAKDVTLNALKTGYRHIDTAFAYGNGRVERGVGQAIQESGISRSEIFLVSKLHNTFHEPDAVGLGLERTLTNLQVAYVDLYLMHNPFAYSHNERYETLRKEDGSNKPVIDLEMSRRYPDTWKAMYELLATGKVKHIGVSNFNILKLQRLMGETGIVPTANQVEFNPYFPQKKLLSFCQAHGIQLVAHSPLGGAPAPAVVGRESNGPLQDPYVNTLAQKYKCTAAQVILSWILARGACAVPKSKNIDRMIENRNCHIPLEVLEVEQMSNLVGRNEEYAVRNLQPKDHIGFNIYDEELDQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCR2</accession>
    <name>A0A2I2GCR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_355698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705962.1">
        <property type="nucleotide sequence ID" value="XM_024844103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCR2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCR2"/>
    <dbReference type="GeneID" id="36551803"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355698"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="471" mass="52657" checksum="01DE4409C50D07EC" modified="2018-02-28" version="1">MNGRAQTRILAPCWSPLHSTVSTRLDPFAPDIPGSGELSDCLLYHCVHVLWPCARPVDFAQGSYHAYLLSGRKSIVMQAVFYSSSLHLDALSTFHGVENYRRHTAAQLFWKGQVLQQIRLELAQINDKTASDELTDDILLCILYLAANENLNSIPPPEQGPFNPPFKSQQLLEYYGNCQFHPLHWEAVEKIVLSRGGIRTVKLYGLGWLISLSALIGAVNSNTKPVFPLVYPDGKPYIYRAPLRALRVPEVSRYSALRNHGFQQLALLSPPIKGNLIRAFLDLGELTQGIEFLASRSCDPNTLTLVGNSRALIQHRLSNLPDSNDQSTAILHRRTDCTYAYCEKPRTIYLVCRTAAVLYSLNVAFPLPRTARQRATMSGEIQNLAMQLQGKQEDAVVELLLWCAMIAGICAHGDLREWFVRQAGDCICALGICSWDEMVVFLRSFAWLGCASDEAGKTFWDEVRMLMTSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCV7</accession>
    <name>A0A2I2GCV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="12">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_455172</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706020.1">
        <property type="nucleotide sequence ID" value="XM_024851508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCV7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCV7"/>
    <dbReference type="GeneID" id="36559207"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455172"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="14">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="15">
        <location>
            <begin position="151"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB50718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="334" mass="36954" checksum="121DE2418C87DF1D" modified="2018-02-28" version="1">MAATTDAAPATCKVMLSKHVANGLLEEVLEGVKTLEKAPHLVGFLANNDPAALMYAQWTEKTCQENGFRYSLREVSREDLEEAILAANADSDVDGIIVYYPIFNNRQDQYLQQIVDVSKDVEGLSHRYIFNMYQNIRFLDPETKRQKCILPCTPLAIIKILEHLKVYNTILPYGNRLFGHTICVVNRSEVVGRPLAALLANDGACVYSVDVTGVQKFTRGEGIKKGRHEVVDLEGQTLKDVAPLCDVVISGVPGDSYKFDTSLLREGAVCVNFSSEKNFGPEVKEKASLFVPSTGKVTIVVLLRNLLRLIQNRRLDDVKPAQATERPGTLEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD17</accession>
    <name>A0A2I2GD17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_446021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706075.1">
        <property type="nucleotide sequence ID" value="XM_024850755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD17"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD17"/>
    <dbReference type="GeneID" id="36558454"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446021"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="272" mass="29774" checksum="0CF73281ECE15268" modified="2018-02-28" version="1">MAQAKDHWSAEAYSTSASFVPKLAQTLLQYLDPQPTDKVLDVGCGDGKYTEAFLPAVQSVLGIDASPAMIDAATKDYGSAKAEFRVVDCCYLKNESEIVNGSWDKVISNAALHWILRNESTRLDTLKAIYDSLKPGGTYVFEMGGHGNIAEVQTAMIFALVQQGISVEKARETSPWFFPSVAWMTSALEGIGFKVEKMETEYRPTKLTDAVNGGLAGWVRLMGAPFLDALPDEKREGVVQQVCGVLQTAVTRHEDGSQWLGYVRLRGIAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE39</accession>
    <name>A0A2I2GE39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G2/mitotic-specific cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_160777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706435.1">
        <property type="nucleotide sequence ID" value="XM_024842569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE39"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE39"/>
    <dbReference type="GeneID" id="36550266"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_160777"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="387"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="480"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="484"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="625" mass="70529" checksum="19A49AE051A9D94F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE48</accession>
    <name>A0A2I2GE48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cofactor for methionyl and glutamyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_436184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706413.1">
        <property type="nucleotide sequence ID" value="XM_024849105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE48"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE48"/>
    <dbReference type="GeneID" id="36556804"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436184"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="246"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="446" mass="47547" checksum="CEAB24981F16BB62" modified="2018-02-28" version="1">MAINSAPETSLLSLLYRSYPAAVSPDATEPDLLTASPKIFPQTTFSVAEEADIKQWLHTISGLQTALVKDEKPVASNILAQLNAHLATRTTLLGSKPSVADIAVYALVAPLVEKWSPEERTGEQGSHHLVRHVDFVQNSRLFSLRIPDEEKIAIDVNDVRFVPKPVDPKEEKERKKKEKAAAQNAGAAVGDKPLVVGQGKPEKKAPEAGEAAEKPEGGKVNKKEKKEKKEKAPKAKPAPAPAAPPTPSVIDLRVGHILRAVNHPNADSLYVSTIDCGDAPGSENTSLDEATGKTVRTVCSGLNGLIPLPEMQDRKIVAVCNLKPVTMRGIKSCAMVLAASPRVTEGEDSHAGPVELVMPPADAPAGQRIFFEGWSEGEPEKVLNPKKKVWETFQPGFTTTDTLEVAFESSAVPAVQGQEGKPALGKLVTASGVVCTVKTLKGAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEA0</accession>
    <name>A0A2I2GEA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_509250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706530.1">
        <property type="nucleotide sequence ID" value="XM_024854655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEA0"/>
    <dbReference type="GeneID" id="36562361"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509250"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="414" mass="45454" checksum="638BDA54A974AD93" modified="2018-02-28" version="1">MQSSREFDLVVLGPTGYTGKLCAEHIVRNLPTNLKWALAGRSVPKIENVAQEIQPLNPDRTPPEILAVQLNREELHNLAQRTKLIINCIGPYVLYSVPVVEACASNGTHYIDATGEPPFIKSVLEKYHDTAKATGAIIIPFMGVESAPADMLSWSLVKRVREELSCHTKEVTCSIDELKSSGASGGTLSTVLTLFDAVPYPELAKSLKPFALAASPPPKTLPRESITEKLFGVRCIPDMGVLATSPTAIADIIIVHRSSTLMPEFYGPKFTFRQFVRVRNVLVGVALHFIFLIAVSLLVLPPVRMLVKQFIYMPGTGPRMEDSTRDRVQYRAVATADQDVQEPKRALGTLKYQGSLYAMTGLLMAQGAMVILENEEKVRKVSRGGIVTPASLGQEYADRLEAAGCYIETKILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEF5</accession>
    <name>A0A2I2GEF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_406941</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706519.1">
        <property type="nucleotide sequence ID" value="XM_024846658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEF5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEF5"/>
    <dbReference type="GeneID" id="36554357"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406941"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="387"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB51217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="486" mass="54524" checksum="E61849C891D38E38" modified="2018-02-28" version="1">MEYLPSLQQEFDELKPSLFELLAEQQLSDLLPPSIRYILAVATHRHPRYLLRILNSYDEIYALVSLVVERYYLRTFGGSFTENFYSLKRERVLLTKNGEVPRAQLGAAGPVRETLKLRSSDVWKNLFVMVGIPYLKRKLDEGYDVHAAPQASLIMSGGPRYNPSDDLPPSPTIRQRLLHLYKWFLRNVYPSVNAAYHFSILAFNLAYLFDNTKYSSPFLWLIGTRIRRLGAADHRAIASVLEPPKPAPGPGGRSRPGSSLLGMLSPQNLYPQLLTSLRYFLPASIFALKFLEWWHASDFSRQLARKATEVLDLPAPVSNGMISPTEKRQALEEKNKEKAKKAQDPDSPKSALKSPRRRIQPPVSASSYLPIFTVPLPPADSDVASMCAVCLNPLTNPTACQTGYVYCYVCIFHWLNGEHQRQIDFMNGEGAGAAWEDDSGDGDDADKQDGKPGQSRQGKWESGKGRCPVTGRRVLGGTEGLRRVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEK9</accession>
    <name>A0A2I2GEK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_353150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706616.1">
        <property type="nucleotide sequence ID" value="XM_024843964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEK9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEK9"/>
    <dbReference type="GeneID" id="36551664"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_353150"/>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25189" checksum="594567329B99AD82" modified="2018-02-28" version="1">MSTPTRIFAGVPLIDTPLVQKAIDFARHHNDTLSFNHAYRSWVFGVIIASKLPSFSDIDHEVHAVSALLHDLAWDCRTSPFVSPDKRFEVDSANAARDFLTREASHFDARQRQLVWDSIALHTTSSIARHKEPEVAVCSMGIFADFRGPQFPGGLLTKAEYNAVVAELPADGFKVGVKELMCELCEKKPETTYDNFVRDFGERFVQGYPLGKGNKVEVLIGRIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEU9</accession>
    <name>A0A2I2GEU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_352232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706717.1">
        <property type="nucleotide sequence ID" value="XM_024843912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEU9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEU9"/>
    <dbReference type="GeneID" id="36551612"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352232"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="222"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="375" mass="43051" checksum="9D5A38C86119D2C7" modified="2018-02-28" version="1">MAPSAVEQESSVSVERVLVKPWARPEPTKEDLDWAPLVQIDLSRFDEPGGKEELAKQLYDAVTRVGFWVVVGHGIDDERVLRQFSLGNAFFKESIEEKRSFPCNFADGEYFGYRENERWIGDTGVKDNVEMLNIPKAIPAWEDVPKHRIVRQNYEEIASFHRDLFDKVLRKLFILISIILELPEDYLADAHGYDERSDDHLRYMIYNTRTREEWAKAQGYTKGGHTDFGSLTLLFSQHVAGLQIRTLEGKWKYVKPVDGGITCNTADTLSFLTNGFLKSTIHRVVTPPADQIHIPRLGLLYFCRPGDNTVMKTVPSPLLERLGLLTEEDKTDQPVATGTEYVRARVRDVHHKKVIDRRENTSFEFKGLKVANYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF42</accession>
    <name>A0A2I2GF42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_400365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706773.1">
        <property type="nucleotide sequence ID" value="XM_024846323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF42"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF42"/>
    <dbReference type="GeneID" id="36554022"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400365"/>
    <dbReference type="OrthoDB" id="47488at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04486">
        <property type="entry name" value="YhcR_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014137978" evidence="1">
        <location>
            <begin position="20"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="605" mass="64541" checksum="6821F40C15577F59" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF65</accession>
    <name>A0A2I2GF65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_487532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706818.1">
        <property type="nucleotide sequence ID" value="XM_024853955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF65"/>
    <dbReference type="GeneID" id="36561656"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_487532"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="431" mass="46239" checksum="FED650D3B91B0CEE" modified="2018-02-28" version="1">MGIEAQEDIPDTGSATRLPETPCGIDPTAASQKWNHPRSNIFRVGTTFWSFLVMGANDAAYGALIPYLEEYYNISYMVVSCVFLSPLVGYVIAALVNNKLHETVGQRGISLIAPPFRLVAYILSCVHPPYPVLVVAYIFAGVANGLAEAAWNTYLGNMENSNEILGLLHGVYGLGAVISPLIATNMITKADAPWYYFYFFMIGISVIEGIACPVFFWQFTGAAFRKAHAGADDATGAGLKDALFKRPAARVSWICSFLLLLYVGVEVSIGGWIVTLMRDVRNAGAFPSGMTATGFWLGITCGRMLLGFVTARIGERVATPIYIACSIAFSLVLWLVPNFYASAVAVSIEGFFLGPLFPAVVVVMTKLLPKHMHVTCIGFVAAFGGAGAAVLPFVAGGIAQGSEVKSLLPFIFAVSVGILILWMGLPRSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFT4</accession>
    <name>A0A2I2GFT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_433617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707046.1">
        <property type="nucleotide sequence ID" value="XM_024848537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFT4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFT4"/>
    <dbReference type="GeneID" id="36556236"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433617"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000478">
        <property type="entry name" value="Cell cycle protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="85"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="495" mass="56415" checksum="336C0CAEBE57701E" modified="2018-02-28" version="1">MSALHTAPAGFFELQRPGSWRPTRPSTRPNHAGADGVVADSDASAAQPQDPVGREEELGDEDIDDSVKEDMQKLEDTFPGISDRFRLVNRIGEGTFSTVYKAEDLLYDHYRNDWDMFQDSHNDSWASPPSKRRRLENESGRPLPPKRRKPRYVALKKIYVTSSPLRIQNELELLHDLRGCRSVCPLITAFRYQDQVVAVLPFFPHTDFRIQYRTFMVADMRHYFRSLFTALHSVHKHNILHRDIKPTNFLYNPELREGVLVDFGLAEREGAEYTGTCLCANPGYVRRSRLLQSYYYTHCSMTTPSAGHPKNDSRPSKRANRAGTRGFRAPEVLFKCTSQTTKIDMWSAGVILLTLLGRRFPFFNSADDVDAMIEMASIFGTRRMKTAAVMHGQIFETNIPTIGEKGYSWEKLVKWASCVEELTESEKQATRLLAGLMELDPYKRMSAKEALQHEFFTEPIDHDVEWGGNPEDSADTGEDGEGDREEEEADEVAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG39</accession>
    <name>A0A2I2GG39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">A49-like RNA polymerase I associated factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_433731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707151.1">
        <property type="nucleotide sequence ID" value="XM_024848563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG39"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG39"/>
    <dbReference type="GeneID" id="36556262"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433731"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54102" checksum="82BAF1B9E4BECFA1" modified="2018-02-28" version="1">MPSDRVEKKRKRASDRHERPSKKPALGLHDLPPLAASVVNDDSELAPVLITTPGVNAPRNIRLTPYLKTRADGPGHSSTRNKGITSSELLLQTSEHPKMDFVGREANDDADSQVKHYVAVVDPQKQTWQFIEARKVTLRGAVRSTKHVAEEEEEESEDEEAKTMRAQRTELTNTFGTKQSRKAAQSMAENAQLSSVPAGASSAAESAILSAMPADSAADLASKSAAVQAQIQAAKPLPQANLEASHPSDVYPIENLVPGGMATLRQLPGVKEWQDTVAAGLSVVTTSRYVSRRLDAVVSSGNVAQIQVLRFIFLLLEFARSLRSGRDPKASGPGGKRLPSRDDLRRILSSSTGAAAASSNTSSSSSTEALPETVIDAVRRKFAPQGTSLSKNDITLLHTTICALSLHIPPQPAKDGGSSSQGGNSPNELATDPSDLRDDLRVDNPIIQHYFRELGCRIDKPRETEFAKWNIKGGKAEAAARRVARLRVPFEFPKTSRGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG63</accession>
    <name>A0A2I2GG63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_350350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707176.1">
        <property type="nucleotide sequence ID" value="XM_024843794.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GG63"/>
    <dbReference type="GeneID" id="36551494"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350350"/>
    <dbReference type="OrthoDB" id="3548913at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1537" mass="171391" checksum="57FA55CF664ECD8D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGY9</accession>
    <name>A0A2I2GGY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BYS1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_444197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707450.1">
        <property type="nucleotide sequence ID" value="XM_024850611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGY9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGY9"/>
    <dbReference type="GeneID" id="36558310"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444197"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014160200" description="BYS1 domain protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16560" checksum="3EFE708557FFB7F0" modified="2018-02-28" version="1">MQIQTLLLTLTLLFTPLVSAVGSAIVKNNCKHPIYLWSVGGSVGPKKTIQPGGTYSETFRRDPASGGVSLKITKVNDGIFNGSPQLNFAYTLDGNQLWYDLSDVFGDPFAGSALVVKPKDTGCSKICWPQGTPPGGSQVKICSADSDETLTVCAASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH42</accession>
    <name>A0A2I2GH42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707494.1">
        <property type="nucleotide sequence ID" value="XM_024852907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH42"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH42"/>
    <dbReference type="GeneID" id="36560605"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472098"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="323" mass="35757" checksum="FF421880CD3A248D" modified="2018-02-28" version="1">MAFLQRLLGLKNQFEVDGKLVLVAGGSRGLGKALALELAAKGANLLLLARNETALRHTQGEVQRACTNSKQIVDAIPVDLTNPDEIHAALNHYHTPDILICTAGGTPTQVGFLADISPQAITSCVDLNYYTTIFVVQYCLKLWLAAAPTSSPRHVLLTSSLAAFVGIPGFIAYTPTKVAIRALADTLRQEFLLYGENTFKVHVSFPGPFITEAFLEEQDNKSRLTKMLEGTELSRPELEQKIPSARVVAKRIIAGVEKGKTYVPVDWQGELLLNNMRGPSPRFWTLWDFFLGMVAACAWWFFRTSWDRQTRRFGVAHGRENGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH94</accession>
    <name>A0A2I2GH94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_444248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707509.1">
        <property type="nucleotide sequence ID" value="XM_024850616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH94"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH94"/>
    <dbReference type="GeneID" id="36558315"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444248"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="337" mass="36698" checksum="3C41387407F69A68" modified="2018-02-28" version="1">MTERSQISHSGEVEDRGPALVIINGVVTAVAALVVGLRVTSRVMIVKKFGSDDWFIIAAVITAILNVVVAGLGVQYGTGKHKWDLSKGDALPAAKLRFVTHIIYTLITALIKASICLLYLRLFPNIRTTTLGTLVFVSAMSLAIILATIFQCSPVDAVYNQQKYKNYTCFPSIPFWYAGAALALATDIWILVLPIPTVLGLKMGTKKRYILIGLLSLGGIACIASVIRMIYIVKLYQSADPSWDTFGVSITSGIEIAVAIIAASIPGTRPIVEKVFPQLFSSTMGTYGTGSAVEGGLRYRNQSRGQVQMSVFTSRRERERQRDRGDDDSMKAIARGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHF2</accession>
    <name>A0A2I2GHF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_462292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707607.1">
        <property type="nucleotide sequence ID" value="XM_024852092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHF2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHF2"/>
    <dbReference type="GeneID" id="36559790"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462292"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="28"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="330" mass="35276" checksum="3070188B91B858B5" modified="2018-02-28" version="1">MSPSHPGRQVSAIRRKHSAVRLINSARQLVGNTPVIQLRNIVPEGCADVYLKLESGNPTGSYKDRMALSMIEEAERRGDLKPGMTVIEATGGSTGSSLAFVCAMKGYKFQVVSSNAFAMEKLRTMQAFGATLDLVHSPSGKITPDLIPSMVERAKEIAKDPSYYFTAQFNNRDALVGYEAIGRELLEQIPSGIDAFCGAVGGAGMVMGSSKILKSKWPHVHVVVLEPASSPVITEGRTGTHGVEGIGIGFRPPHLEDTLYDEARGVPEADARAMCRRLAKEEGLLVGTSTGMNVVAAVDLAQRLGQGKKVVTVACDTGLKYMNSNLLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI28</accession>
    <name>A0A2I2GI28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_105895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707832.1">
        <property type="nucleotide sequence ID" value="XM_024842290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI28"/>
    <dbReference type="GeneID" id="36549985"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_105895"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="87" mass="9332" checksum="BDD70EB7A27F65BF" modified="2018-02-28" version="1">MTSLGRSGLKGQLEPQTPLLVTEGMPFWLFLFFLGPARLQSTSSLLAGVAAILGHPPISSAMSHGLMPYPERVNGSVANEYKSFPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI94</accession>
    <name>A0A2I2GI94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_434317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707907.1">
        <property type="nucleotide sequence ID" value="XM_024848688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI94"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI94"/>
    <dbReference type="GeneID" id="36556387"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434317"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="254"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB52605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="346" mass="38034" checksum="322F0ED677E3A06B" modified="2018-02-28" version="1">MTGPSIQDRTGEFHAILGQAQKRMASSKVGSQRQNLLSETQRRQANGYEDGNAPGGKRSRSEFARKAAEIGRGITATTAKLQRLAELAKRKTLFDDKPVEISELTYVIKQDLAALNQHIAGLQALTLAQHPKAGRSKADQEGEHNDNVVVMLQGKLADVGANFKEVLEVRTKNIQASRSRTENFVSSVSSKSQSALDTQRSDSPLYNPSGRRTPQPGGASDLLTLEPSNPSPLGRPSMHSDQQLLVMEEAQSSNSYIQARGEAIDAIERTINELGGIFGQLAQMVSEQSEMIQRIDANTEDVVDNVQGAQRELMKYWVRVSGNRWLVAKMFGVLMIFFLLWVLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIQ7</accession>
    <name>A0A2I2GIQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_111958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708068.1">
        <property type="nucleotide sequence ID" value="XM_024842320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIQ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIQ7"/>
    <dbReference type="GeneID" id="36550015"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_111958"/>
    <dbReference type="OrthoDB" id="3557178at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="201" mass="21074" checksum="6BBC289B7D356E06" modified="2018-02-28" version="1">MDGIMGQTTAVNTSIQSDSGFIGWYLGPSTTQALMDPATWTTSGRYARGCSANDTCAYATNCQDNRITYDNGKICACPTCRTMTIFQTAPYETPSASNVFCANYWVAFTIFRKLPATTTSSEPSTITTAASTSSTTLPSATASSTALPEPDASPTGSSNSNQAWIAGPVVGSIAAVATIAAFYRPKSPTTRCTDTRDGCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJR8</accession>
    <name>A0A2I2GJR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_351057</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708425.1">
        <property type="nucleotide sequence ID" value="XM_024843837.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GJR8"/>
    <dbReference type="GeneID" id="36551537"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351057"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="57"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1888"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2150"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="491"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2284"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2293"/>
            <end position="2307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2316"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB53123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2326" mass="258906" checksum="E445EC1B17D36015" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK59</accession>
    <name>A0A2I2GK59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_127409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708566.1">
        <property type="nucleotide sequence ID" value="XM_024842390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK59"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK59"/>
    <dbReference type="GeneID" id="36550085"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_127409"/>
    <dbReference type="OrthoDB" id="3945550at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="200" mass="22016" checksum="BEA1333F65F7E13B" modified="2018-02-28" version="1">MSPGWSAMSLTYSFPLEFSFHGEFPMTQSFADALSKHKRSPQLHLLGEQGRTQVTKEMSFVCALHTRVDAHAYPHRPPRATRRYVRPWDLEPETLNLHELFTAYPNLESLSVSINRFKGGCVVGGPPSPIPSDAVHEPNLSASAKSISKWLLYPRRGAPLEGKVSLAQAAVPQPGQPGLSGLLGPGEGPCTWVDTFHYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKN4</accession>
    <name>A0A2I2GKN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_463126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708740.1">
        <property type="nucleotide sequence ID" value="XM_024852142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKN4"/>
    <dbReference type="GeneID" id="36559840"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463126"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="282" mass="30935" checksum="2F40811CC0E886E5" modified="2018-02-28" version="1">MSPSTFDLQKCTHLIIVCCHAIYIGGPTKGISEDEWLIEPFQKGETPTFTAHVKAGIQAAAEDLRSVLVFSGGATKRSLTSLAEGESYLNLAKDNALFTFSDKLHASQITTETNATDSYQNVLFSLLKFKTHTGRYPTRVTVVTHEFKRKRFMECHFPAVGLGPVSSPAGAGDQGGDRTSRCKCKGDVIGINPPEEVTSSASLIAGEEKRGIGLWREDRYGVQAELAGKRAQRGWTAGMERDVFGDMGLEAVVEELVCWDGGEDGNKWFSKMERLPWYSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKQ5</accession>
    <name>A0A2I2GKQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate lyase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_490616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708758.1">
        <property type="nucleotide sequence ID" value="XM_024854002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKQ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKQ5"/>
    <dbReference type="GeneID" id="36561703"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_490616"/>
    <dbReference type="OrthoDB" id="4207132at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="2">
        <location>
            <begin position="272"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="380" mass="43219" checksum="600C0272B4ECEE1E" modified="2018-02-28" version="1">MASSTYRQKSLTDSELYFEFGVWKIGKNLSSKFRQQEDPHGGFTCERHEVYEATRIDQPSKTPDVIKIKKQIVFWSNRGYSEPSDEVNREIYNLSQLEECRSTPKLLGYAVGTQDSSDHLPGGYIAYIVMQKVPGENLHGFDTLTKAEQNRIRVAFIDSLWELVSRYFTHRDPRRENIIWDPRMGQCFIVDLEDAEQHTNRTKHDPDFTVVSQWYPGRHKTRGFVLPSSTSPTLPPAMNSSFASSQPHAATSTRYSHPDKCNKSYPALGKKTPMHPNDHINMSGSSSDGFGSAMHIAAAMEIEGLLLPALDSLTEALKSKAQEFQDIIKIDRTHLQEAVSLSLEKEFSGFVERLELGRKRIVETVEGLRYLPLSQYLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKY8</accession>
    <name>A0A2I2GKY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipa and NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_454546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708829.1">
        <property type="nucleotide sequence ID" value="XM_024851446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKY8"/>
    <dbReference type="GeneID" id="36559145"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454546"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="737" mass="82255" checksum="09CA1DFC4A1AE30D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLK3</accession>
    <name>A0A2I2GLK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_396402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709058.1">
        <property type="nucleotide sequence ID" value="XM_024846116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLK3"/>
    <dbReference type="GeneID" id="36553815"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396402"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB53756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="698" mass="77087" checksum="850EB9536E72B258" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM80</accession>
    <name>A0A2I2GM80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709277.1">
        <property type="nucleotide sequence ID" value="XM_024848103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM80"/>
    <dbReference type="GeneID" id="36555802"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431710"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="83" mass="9012" checksum="981B539FF814B431" modified="2018-02-28" version="1">MSSYVGSSRPGSSSMGDNASAYGSSSRRSSVSRADVSTSSRRRTDRRYPPTSQHAAFNIPDDRYVYYSSTTTSGGHHTPASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMV0</accession>
    <name>A0A2I2GMV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_397336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709505.1">
        <property type="nucleotide sequence ID" value="XM_024846168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMV0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMV0"/>
    <dbReference type="GeneID" id="36553867"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397336"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000005">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF23">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014135137" evidence="2">
        <location>
            <begin position="29"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="290"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="798" mass="88385" checksum="D208BF45E9E5AA3E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMZ5</accession>
    <name>A0A2I2GMZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_452021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709521.1">
        <property type="nucleotide sequence ID" value="XM_024851243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMZ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMZ5"/>
    <dbReference type="GeneID" id="36558942"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452021"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="356" mass="38275" checksum="4F50D348D199CE65" modified="2018-02-28" version="1">MPAANRQLIYANTPSPAIDPSLDNGTFKLNTTPIPDNVPDDKVLVRVHYLSLDPAMRQWLTAKRSYIAPVERGQIMRGQSIAQVLRVGAGLQSKYQAGDWVVAYSGWQEYALLGAKEAQKVTVPAGCQPTDAMSVLGITGLTAYFGMMDVAKPKAGETVVISGAAGATGMVAGQIARVQGAKRVVGLAGSADKCEFLRRELGFDAAINYKDADWKKQLKEATPEYIDVFFDNVGGEILDACLARAAKDARFAICGAISQYNAAKPQGPASFMTVISQRVMMKGFIVLDYTKQYPAALKDLATWLTQGKIKRKEHIVPGGLESAPKSLVDLYEGINTGKMMVEVAPVSEAIAVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNF3</accession>
    <name>A0A2I2GNF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_469873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709709.1">
        <property type="nucleotide sequence ID" value="XM_024852683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNF3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNF3"/>
    <dbReference type="GeneID" id="36560381"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469873"/>
    <dbReference type="OrthoDB" id="5153231at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="621" mass="71013" checksum="AE676AD35F01C484" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNJ8</accession>
    <name>A0A2I2GNJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_346640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709742.1">
        <property type="nucleotide sequence ID" value="XM_024843579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNJ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNJ8"/>
    <dbReference type="GeneID" id="36551279"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346640"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="273"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="524" mass="56855" checksum="85510C0DEBD61B31" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPM7</accession>
    <name>A0A2I2GPM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="4 10">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_374216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="4 10"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710121.1">
        <property type="nucleotide sequence ID" value="XM_024845279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPM7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPM7"/>
    <dbReference type="GeneID" id="36552979"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374216"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB54819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="349" mass="38939" checksum="9E381C6F9C420EB5" modified="2018-02-28" version="1">MSAEAMMIDETGMGQECRVESLPMGAQLVYLAEGGANVIYRIVSIKSSAHGSKNGSYSVPAEFKGKLLRLRKDTSSGIAYQEIARNFDRTIRPLFNPEELVDQELVKLPKGLVQQCNEQLHAAELNGRRPKRRHGVYLSVTEPFGLLITDMTVFENPGMILAELKPKWLLQSPSAPATGRRCRTCALREMKNHEARRAGKSEDRSFCPLDLVSERFENVLRATKYVKGCKDQMRLATVLYRNPTLQKLLSHQKATRDVGLYGPPAQSREKSLAMTLRDCTMFIKMPLDDLGAVEIRLGDLDLKTGAGGKAQYWHDLEKQLIDQGWYMGCKGCSATSECALHVRGSQSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQV2</accession>
    <name>A0A2I2GQV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF125-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_443092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710545.1">
        <property type="nucleotide sequence ID" value="XM_024850508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQV2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQV2"/>
    <dbReference type="GeneID" id="36558207"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443092"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="264" mass="27201" checksum="1A3C932D634A6866" modified="2018-02-28" version="1">MALLFLKQKLFPTHNSQSKNSSGSPAHLYTGSTRSRINPRIVSDAILGLSDGLTVPFALSAGLSALGDTKVVVLGGLAELAAGAISMGLGGYVGAKSEAESYETTVRETNALVAASSAETSAIVHSIFAAHGIPEPAVAQINASLHASPANLRDFLVAFHHKESAPDCNQAWISALTLALGYFVGGFIPLIPYFVVDRVIVALYCSVGVMAVTLLVFGYIKTGVVRGWRGSENVLAGLWGGVQMVLVGGIAAGAAIALVRVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQZ2</accession>
    <name>A0A2I2GQZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_37576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710602.1">
        <property type="nucleotide sequence ID" value="XM_024845333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQZ2"/>
    <dbReference type="GeneID" id="36553033"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_37576"/>
    <dbReference type="OrthoDB" id="5425637at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014129662" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18713" checksum="3E8FBDEF97FB72DA" modified="2018-02-28" version="1">MSSPTPAFYYRCLLISLFAYSAAQDIGDDVESQNRAGAEGPSDDGVGVSSTGMIILCTIVGVVAVIGISSAALFFVAKRRQWAMRETLRRSARHVVDAVKTPLTPKFSRSQLRQPPSQSSLNPKRTATDQTIKNKRGDDDLEKNAVVTEIEASGNNDSKPRTWGSMFAFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRD7</accession>
    <name>A0A2I2GRD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_506036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710740.1">
        <property type="nucleotide sequence ID" value="XM_024854345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRD7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRD7"/>
    <dbReference type="GeneID" id="36562051"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506036"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB55438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="509" mass="57509" checksum="B8FCC415630A99F7" modified="2018-02-28" version="1">MAEKSQLLPFRQVVIIGAGFGGLAMACDLKRKLKFHDFVIYERNPGLGGTWYDNNYPGAVRLSSSKHLRDINSRNNNQAADIPGSVYQLSFAPEPNFTHVFPDRAQLHTYMLDVAQRFHILPYLQCNIAWVGSTWLDERKCWSVELQNTQTEERYVQECAVLISAVGHMVDPKRFEVPGMETFKGQIIHSSKWTDGVDLKGKNVAVLGNGSTAVQIVPAILDDVKQCTQIQRSPQWILNRPNPYVPSSLRKCLALFPILFVLLQHCGFALAELFYPLLGRRIPRLSKSHLRACGVPEKYHSLLTPSYEPGCKRLVFASSYLQSLSNPKLHLQQDEITALTDSSVVLRSGTPVPCDVLILAHGFESDTFRFPVRGREGRTTAQHWDEAGGPSCYRGCAMHGFPNFFMIRGPNMASGHNSVIYYIEATVSLILKIATPLIEGRLRSVEIKSEVEKSYVASVQEACRKGVWGRGCSTYYVDGTGWNHTIYPWTSYWLWFHRFERVGDWICEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRL8</accession>
    <name>A0A2I2GRL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_506103</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710823.1">
        <property type="nucleotide sequence ID" value="XM_024854360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRL8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRL8"/>
    <dbReference type="GeneID" id="36562066"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506103"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="11">
        <location>
            <begin position="306"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="436" mass="48170" checksum="79BACA319DAEBB1F" modified="2018-02-28" version="1">MLQVPVREHTNVASTKAIILVGGPSRGTRFRPLSLDVPKPLFEVAGHPIIHHGLKALAKIPDIREVILVGYYDESVFRDFIKDSAKEFPQFRIQYLREYTSLGTAGGLYHFRDAILKGKPERIFVLNADVCCSFPLGEMLKLFEEKDAEAVILGTRVNNDAATNFGCIVSDSHTKRVLHYVEKPESHISNLINCGVYLFATECIFPSIRSAIKRRTTRPRLVSYPSSENLESSFIAAEDEEKSEVLRLEQDILSDLADSNRFFVHETKDFWRQIKTAGSAVPANALYLQKAFQAQSEELIAPSATIVPPVYIHPSASVDPTAKLGPNVSIGPRVVVGAGARVKDSIVLEDAEIKHDACVMHSIIGWSSRVGAWARVEGTPIPMGSHSTSIVKHGIKVQSITILGKECGVGDEVRVQNCVCLPYKELKRDVANEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRM0</accession>
    <name>A0A2I2GRM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_443287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710830.1">
        <property type="nucleotide sequence ID" value="XM_024850528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRM0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRM0"/>
    <dbReference type="GeneID" id="36558227"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443287"/>
    <dbReference type="OrthoDB" id="5383967at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014189410" evidence="1">
        <location>
            <begin position="19"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="467" mass="50024" checksum="9544B3CF238312FB" modified="2018-02-28" version="1">MLYPVDFTAFALFAAVQAIPSHQPHLYKRCGPVQEFYNQNQGDWDTYNTTDWLNSWWDGHTDQVSSNTAGFAGAFGQWAMGNPDWSCSDSGSNTDCDLNLCDNRVLNDKGDDIRPAYYVLESVNRLHTYFTGLGEAFTTTALGAALSKDEWALTFYKDKDAKSVTALKEALNAVTTIVDIGATFAGLGPAVGGAVAGAGSALLSGGIAAGNLVLGDHKDDTFEKSADLGSILGTVVVDSLKSFTTANNDLMAGKEHNEADIRSYLSGGVFLDYSGVDKNVVTDSMTAMMIFIMGDGACGDDQGIGSGPQEAVVCRDDRAWYLYYWQENDVVSTTAHQWGWGPYSGISIEDIINSSLDAYNAAGYDYNADKATERASDAVSNAWASLGKKGASCEGVFTIPVCDVGGAVNSDFESKEYILQPYGHDMRPVWCGAICGGDQQTTQIFINAANMGGFKSPKHLCSEDPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRX5</accession>
    <name>A0A2I2GRX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710924.1">
        <property type="nucleotide sequence ID" value="XM_024848412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRX5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRX5"/>
    <dbReference type="GeneID" id="36556111"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433128"/>
    <dbReference type="OrthoDB" id="5430106at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="664" mass="71783" checksum="9C4E8138745B2B43" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSH2</accession>
    <name>A0A2I2GSH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_506334</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711124.1">
        <property type="nucleotide sequence ID" value="XM_024854385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSH2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSH2"/>
    <dbReference type="GeneID" id="36562091"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506334"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="286"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="475" mass="51979" checksum="2ABD73279E4DCF9B" modified="2018-02-28" version="1">MATNRALALFARHSLRHKNPSLSRFPHPQSRQFSSPPRSDIAEAAPQQSFAYGANDEVARLAASRRRPLTLADLLKHGRPPLSKDALLASANYTLSLLPARLASRIEALRNLSFIVVSNPHISKIYNNYLHSLSTLLPYQQRQVTTLEEENKFAEVLADLVHTHTNTIPILARGFLECRRYIDPTEVTRFLDTHLRARIGTRLIAEQHLALHFASQPVSDVDTGSQPAPQSTAPSNYIGVIDTALQPARIVKLCEDFVGEICELKYGVRPRLKIGGQPDAAFAHVPVHVEYIITELLKNAFRAVIEAGNERDPIEVTIVAAPDVPRDHGRVDYPSTLAGISTTQSDSDVGFQMDTVVGTADANESIKVSAPSSQSITIRIRDRGHGIPPEVLPNIWSYSFTTFSDLDLQGSENGNMDAFNAISNNSGQLSSIAGLGYGLPLSRAYAEYFGGSIAVQSLWGWGTDVYLTLQGVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSK8</accession>
    <name>A0A2I2GSK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_51149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711163.1">
        <property type="nucleotide sequence ID" value="XM_024854895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSK8"/>
    <dbReference type="GeneID" id="36562601"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_51149"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="140" mass="15861" checksum="4D7CFDE97E0D6B96" modified="2018-02-28" version="1">MRSMELILPTSIYFPNQTPPLLSSALLKVTSPKKENSIPCIFWRFRGTLCLNFFFSAPLVQAVLLLSSIRDYHYLYRTCTPAGFPGCTCYLLLRLAVLASDHIILSPSTIFAPPSLLPPYHSLRGSDLLSSFFLRRFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQQ0</accession>
    <name>A0A2I2FQQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_370603</name>
        <name evidence="9" type="ORF">P170DRAFT_370650</name>
        <name evidence="8" type="ORF">P170DRAFT_370692</name>
        <name evidence="7" type="ORF">P170DRAFT_370780</name>
        <name evidence="6" type="ORF">P170DRAFT_370878</name>
        <name evidence="5" type="ORF">P170DRAFT_370996</name>
        <name evidence="4" type="ORF">P170DRAFT_371107</name>
        <name evidence="3" type="ORF">P170DRAFT_371509</name>
        <name evidence="2" type="ORF">P170DRAFT_371531</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000028">
        <property type="protein sequence ID" value="PLB42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000027">
        <property type="protein sequence ID" value="PLB42794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000019">
        <property type="protein sequence ID" value="PLB42911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB43015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370603"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370650"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370692"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370780"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370878"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370996"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371107"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371509"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371531"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00034">
        <property type="entry name" value="Antisense to 5.8S rRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB42973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="91" mass="9831" checksum="E23335308AA8385D" modified="2018-02-28" version="1" fragment="single">IPPGIPGGAMCVQRLDDSLNSAIHINYRISLRSSSMPEPRDPLLKVLTDCDTIDSDDKTSDSVHVGVSGGRSPGGKPLPRRPRGRRARRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR81</accession>
    <name>A0A2I2FR81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_418822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698423.1">
        <property type="nucleotide sequence ID" value="XM_024847244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR81"/>
    <dbReference type="GeneID" id="36554943"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418822"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="13946" checksum="8726338525B4C18F" modified="2018-02-28" version="1">MTMARHTSLDSERPIMTQSNRTSKRFSTVSGSPSVASSERTLGNLPSGDPRLAEFHNLRDGLERLENKPLQKQRFVPTPEKSDNLSKLALGAKVERALDRRMTGQDAIMRKPILDEKAALESSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRM2</accession>
    <name>A0A2I2FRM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_514523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698563.1">
        <property type="nucleotide sequence ID" value="XM_024855213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRM2"/>
    <dbReference type="GeneID" id="36562919"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514523"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014179696" evidence="1">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="295" mass="33784" checksum="09E4FA07A3969D69" modified="2018-02-28" version="1">MARHTLSLLACTCWGLLSLVGAQRHEFSFDELWKMEHNFWDQFLYPANLKQINATDESVFAEDIQGRVDITRTFDGRELNNEYIFGLFAQPDTISLTGVPINYTVTQFAGNQNLAAATTVLTFNVTTFNVLLPLVIDTWIEFNPDGKIAQYDATFRWFDYYVSTLLTVAAKNFNTTSEAETQAKIAGIVADSICAQSMKYCGDYEHYESHEQCVQYLTEETRFGQPFELGRDTLLCREVHKHMVGYRPDMHCSHIAPSGGDYCVDDMGYRDVVLERYFEDSWVGFDYAEDNIWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRX9</accession>
    <name>A0A2I2FRX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_394939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698692.1">
        <property type="nucleotide sequence ID" value="XM_024846080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRX9"/>
    <dbReference type="GeneID" id="36553779"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394939"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000295">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="519" mass="57105" checksum="27D4958C199328C7" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS15</accession>
    <name>A0A2I2FS15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable exo-1,4-beta-xylosidase bxlB</fullName>
            <ecNumber evidence="14">3.2.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">1,4-beta-D-xylan xylohydrolase bxlB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Beta-xylosidase bxlB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Xylobiase bxlB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_469023</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698724.1">
        <property type="nucleotide sequence ID" value="XM_024852586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS15"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS15"/>
    <dbReference type="GeneID" id="36560284"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469023"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000013">
        <property type="entry name" value="Probable exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014175386" description="Probable exo-1,4-beta-xylosidase bxlB" evidence="19">
        <location>
            <begin position="22"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="665"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB43422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="766" mass="82683" checksum="AF8BC32099DDB9BB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS88</accession>
    <name>A0A2I2FS88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_393217</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698785.1">
        <property type="nucleotide sequence ID" value="XM_024846011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS88"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS88"/>
    <dbReference type="GeneID" id="36553710"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393217"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
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        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
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        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="29"/>
        </location>
    </feature>
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        <location>
            <position position="264"/>
        </location>
    </feature>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB43483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="684" mass="74330" checksum="CA2FC325CD144470" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FST4</accession>
    <name>A0A2I2FST4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_430713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="PLB43674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024847971.1"/>
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    <dbReference type="OrthoDB" id="4505027at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
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        <location>
            <begin position="64"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
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            <end position="247"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="262" mass="27952" checksum="0B23A968C0D74372" modified="2018-02-28" version="1">MTQPIQQPSNLHFRSESNTLSPAGKVGLILGLIGVTLIVLLVIFTVLRLKRGPVITLSSFLPHPSRKSASLRNLPSGDIERGLRSRSRATTDRSGSRATTTRTTRTTEKDSLVGGRNSRHQTSSPANSHRKATAAAAAAAAGHPSSLDKEIGLGRSAGGDGSSRGRVKVTTRDFHADPQGPTRPVNTSRGVNHTVAVTMPVSAYARPHERMRDPPVRVPPNPVLSPRMPPSPAFSRLTTSTRSSAALPSVRFMPGMRKSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2I2FSW8_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_369279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024844900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSW8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSW8"/>
    <dbReference type="GeneID" id="36552600"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369279"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="242"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="661" mass="74110" checksum="1A0105CB702091F1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSY2</accession>
    <name>A0A2I2FSY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_369483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699042.1">
        <property type="nucleotide sequence ID" value="XM_024844907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSY2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSY2"/>
    <dbReference type="GeneID" id="36552607"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369483"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000030">
        <property type="entry name" value="Quinate 5-dehydrogenase QutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="356" mass="38063" checksum="A3615AE833C2DEA4" modified="2018-02-28" version="1">MQSPPEEPISIPDHLDGVAYLYGHPLLNSLSPPLHQTVYTTLGLNWTQIPLSSVTGTSATYPPPYTRSPPIPTFLASIRNNPKFVGSSVTMPWKVGIMPHLDDLTEDAKQAGACNTIFLRKDPATGSTAYVGTNTDCIGIREALLQNSPSTSGDPVAEIFRGRPALIVGGGGTARTAIYVLRKWLGASKIYVVNRDTAEVNAILAEDAQRNPNSDGSLPPLIHVTDPAVAAGLEPPAAIVSGIPNYPPETAEEIRAREVLQAFLGEETDEKATEGKKPRGVILEMCYHPSPWTEIAGLASAAGWKVILGSEALIWQGLEQARLWTGQDVVKVPGVVEKVKELVAKSIAERAAKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTA4</accession>
    <name>A0A2I2FTA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_480819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699172.1">
        <property type="nucleotide sequence ID" value="XM_024853813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTA4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTA4"/>
    <dbReference type="GeneID" id="36561511"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480819"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001067">
        <property type="entry name" value="C2H2 transcription factor (Egr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="30395" checksum="CFEAFC901334B8D2" modified="2018-02-28" version="1">MASCKGSFVSILNNDDNPSFAVRSAPRITRHQSSPTYPHEQPRHAVGLDYRYGPAYSESPAVSPRVTRQPFNPVSEATQPTSPGSSDCSYDYTTSASAGSYFQHGRQEYPGYSSSAMPAPEKRLSANSMVDPPSPPTSIGGSKDTTAARGTRKNKYPCPFAASHGCSATFTTSGHAARHGKKHTGEKSVHCPICNKAFTRKDNMKQHIRTHRTHSEDMPMGMVERESEGSSGWRSRRTSPTYSHQRSVSQSQMDGNAYESMTTMNSMTSSGTHRSQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTH2</accession>
    <name>A0A2I2FTH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_480861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699216.1">
        <property type="nucleotide sequence ID" value="XM_024853818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTH2"/>
    <dbReference type="GeneID" id="36561516"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480861"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="335" mass="38572" checksum="19F9CC073E245DCC" modified="2018-02-28" version="1">MPVILPDMFVSFLASPPEINPHYDTIRTQSETWLSRECSFSPKFQHTLHQLDFSYFCSVVIPLASFTKLRPLCDWGNWVFPFDDAFDNGPLQRDPAGAQEMVDACLSIIDGRNAAPEQPILHAFKSIWDRLSQQAPHGTQKRFVKYMTTFCESNIDQVTLHSASKIPTIDRLIELRRGSIGATPIFALVEYAYDLELPDSVMQHPIIEKLGEIITDIVLIQNDIVSYFKEQDLGENHNLVMVYLLKVGDITTAFDECASLLHSRYREWYSVLAQVPFWNEQIDSQVQQYISGIRNVAAANLNWSFRTDRYWYGHNTRVRQTRDVSMLVKEERSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU77</accession>
    <name>A0A2I2FU77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_392237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699463.1">
        <property type="nucleotide sequence ID" value="XM_024845965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU77"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU77"/>
    <dbReference type="GeneID" id="36553664"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392237"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="10"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="360" mass="38987" checksum="5FFA7F3A3E72B053" modified="2018-02-28" version="1">MRSVGTTTYSPPSGYQMLDLPKPELKGPKDVIIAVHAGSVNPIDVKYAGGAMKMVVSDTFPSPIGFDCAGTVTEVGSNVTRCKVGDEVYTRLPGSCRGSWSEYARCPEECLALKPSSLSFEDAASIPLAALTALQALRRYDGDLEGKTVFIPAGLSGTGSYACQLAKNVFKAGKVITTVSTAKIPKVAEYLGENVVDEIIDYKTSNPLTRIPAKSVDFAFDTVGQAMDFLPLMRPNGCIISIAMIPSGDQMQQWDLLRLPHNPTVPIYVRIPLNLMDSYRRRKARCSSVQYEYLLLEPNGKDLDSLTEWVEEGKLRPVVGTVVKFDDLEAVKKACQVVYDGQGGIGKAVISMGKGSIEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUE8</accession>
    <name>A0A2I2FUE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alb1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_440566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699554.1">
        <property type="nucleotide sequence ID" value="XM_024850106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUE8"/>
    <dbReference type="GeneID" id="36557805"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440566"/>
    <dbReference type="OrthoDB" id="5304887at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19343" checksum="5E8FCDCCA1E0628B" modified="2018-02-28" version="1">MAKTRTQSKHSRAARREASPSLEVDKSVMSLPRVEETSLPRDSILADRANAGVSKKQAKPRNKSRAQRQKQQKGIERAENVIDQMEKKVTKSVSRAKTVKARRGEWEDLNRKSVASKFQALENEFDDNDDDDAMVDDSAPPAKTRKPKSQQTNATQNPVADEPAGIDEDEDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUS5</accession>
    <name>A0A2I2FUS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_450504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699676.1">
        <property type="nucleotide sequence ID" value="XM_024851129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUS5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUS5"/>
    <dbReference type="GeneID" id="36558828"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450504"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="497" mass="54820" checksum="0811CB3D896FF369" modified="2018-02-28" version="1">MGKFYTIGVACFAATGSFLFGYDSGVMTDVIASPNFLEFFDTTKTSSIIGAINSTFSGGAAIGALTAGLTIDRFGRKATIQLGALLATIGAILQCAAMQLAMILVGRIVAGWAVGTMSMSVPVYQAECAHPKTRGFIVGLAQQMIGVGFIVSTWIGYGSLHAPDDNSVQWRFPLAFQGLPSIMLFFGLFWLPESPRHLIEKKKDEEALRVLKRLHYDGTNEDWIQSEYTEIKATIDAEREITAPGWLVMFQVPQWRTRLFQGTLVQVFTQMTGINVINYYQNIMYENLGITGNRATLVTGIYNVVGPLANLIFITFFLDRVGRKKPLIFGAAAITIALVCEAALNSQNLDGTRTSYSIGGVFFLFCVTCLYSVSFGSISWVYMSEVMPMQIRGKGNAFATGIGNWVVSTIWSQVSPIALDKLGWKFYFIFACFNVVVTIPTIFFWFKETKQKSLEEIDLLFGGRALGMLSNDLNEKGLEVDHHSAVEQVEHATEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUU8</accession>
    <name>A0A2I2FUU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_480167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699704.1">
        <property type="nucleotide sequence ID" value="XM_024853759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUU8"/>
    <dbReference type="GeneID" id="36561457"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480167"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="12562" checksum="3B2EFC873EFF6750" modified="2018-02-28" version="1">MPIRDEAKSRAQNQRQVHHVAISQSEAVRSVVHLPVDWRLIFLPISPLMFVAIELTIRFLNPSLPLYAAQRSLGPSDFLSPLLSQNPTSNEPVLRSPTRVAWAAFIHEFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVG3</accession>
    <name>A0A2I2FVG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MJ1316 RNA cyclic group end recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_339583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699916.1">
        <property type="nucleotide sequence ID" value="XM_024843389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVG3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVG3"/>
    <dbReference type="GeneID" id="36551089"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_339583"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042653">
        <property type="entry name" value="Leng9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729:SF1">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="1">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="103" mass="12177" checksum="F292DAB3A4087A83" modified="2018-02-28" version="1" fragment="single">TQTPVSMENRLRPAADIINRIIWDSNYDSANYIIGYEDRFEGRLEVGIGSWKKESTDEEFIPQHRVLYIKRKSDGEIMWDRRRRIDKLFLSGNSAFDFLAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVP6</accession>
    <name>A0A2I2FVP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_439956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700010.1">
        <property type="nucleotide sequence ID" value="XM_024849956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVP6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVP6"/>
    <dbReference type="GeneID" id="36557655"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439956"/>
    <dbReference type="OrthoDB" id="5367584at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024312">
        <property type="entry name" value="TACC_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12709">
        <property type="entry name" value="Fungal_TACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="777" mass="85976" checksum="37044435AC22C2A2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWA2</accession>
    <name>A0A2I2FWA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700196.1">
        <property type="nucleotide sequence ID" value="XM_024849992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWA2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWA2"/>
    <dbReference type="GeneID" id="36557691"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440099"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="318" mass="36510" checksum="0416D979F4781155" modified="2018-02-28" version="1">MRLSYRVGLAALFIFAVVLIKRHLDFLQDDTRPQSVWQLNLGGNSGSQQQEQQQQQAPNQGSNGPAVNPPVKIAQPTYETTPIIVPNDRVIVMAKLAAEDTSWVSNELAEWRNFIYTVDDPNAARHTPKNKGRESLAYLEYIVDHYNDLPATIVFLHSHKDGWPGAWHTDTMDYSNVQAIRALQTDFIQRNGYANLRCQETPGCPDEIRPRGDSHRPGKSTEKVYAQAWQELFNNTDVPEVVGVPCCSQFAVSRDQVLKRPLTDYEWFYAWVLNNELEDDVTSRVMEYTWHIIFGQDPVYCPDAFQCYQDVYGNPYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWA5</accession>
    <name>A0A2I2FWA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700148.1">
        <property type="nucleotide sequence ID" value="XM_024849982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWA5"/>
    <dbReference type="GeneID" id="36557681"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440060"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="52" mass="6069" checksum="6B5A3D4AB01BC430" modified="2018-02-28" version="1">MARRFFPGQNAAFGLSLFLFTFMFLPTLVMLLAVVVLVIMYYPRLRKTTHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWE7</accession>
    <name>A0A2I2FWE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_513071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700271.1">
        <property type="nucleotide sequence ID" value="XM_024855058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWE7"/>
    <dbReference type="GeneID" id="36562764"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513071"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="131" mass="15057" checksum="B5543DCED5F0FA85" modified="2018-02-28" version="1">MHPYLAVAIYHPRYGNFQHWALHLHTSTEDTIYEVDGEHPSFQKVTSSGNPRDSETFIHAIFVSEVGDPDIPTIRAIVDGARVDNETLEWDCQEYVLEIIEACEQEAVLDDHDLEYMEAKETLKQKRGPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWQ8</accession>
    <name>A0A2I2FWQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_440205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700360.1">
        <property type="nucleotide sequence ID" value="XM_024850024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWQ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWQ8"/>
    <dbReference type="GeneID" id="36557723"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440205"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="60"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="481" mass="52433" checksum="F46E31D0A1C2F06D" modified="2018-02-28" version="1">MSPTADSILLRNGTILQHEGQEVRSLKECDLLIEGDKITGIGQNLAPPTGCKEVDCTSKIISPGFINGHHHLWQSQLKGRHGDQGFMEYMASGNLQSYNYRPDDIFWGQLGGCLQSIDGGVTTVVDHAHMTYSPQHATEAIRASASSGIRSVFCYTLIRRIREWSSTVEFEEEFLPEWWLQTLESLAGAAPVGNGRVTLGLAVDPGVPVDILARLWEKAQALGLKLVTMHYVAGLMKNAVQLLSENNQLTSNVLISHGNGISTEDAQTLINHDIFICSTPETEMQMGLGNPVAFRHDLKSHTCIGTDCHANNSADILTQMRLGLQHTRAVSNDEAFRKGEYPSVDITLEQAFNLGTIQGAKAIRMEDQIGSLVVGKKADILIFDASSPSMVCAAEENPLAAVMLHASVRDIETVIVDGKVVKERGVLKPVEIQRTLDTADTTLLDWSEVSQQLLQSRERVLERAEGQDVSAGMAALMGGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWR6</accession>
    <name>A0A2I2FWR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_415994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700382.1">
        <property type="nucleotide sequence ID" value="XM_024847095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWR6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWR6"/>
    <dbReference type="GeneID" id="36554794"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415994"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="498" mass="54132" checksum="589AD47642D616F2" modified="2018-02-28" version="1">MVANFQHPFQRVQFVDRQHAGHENLIVASAGPKLYSYAAETGQQLASWPQDEDQSNVDGQGPPEKKRKVSAADEAEVEPPASTNGTSGKPKPPAWSSIPLLVASSTGEHVVAMTSEDKCVRVFQLGQDGSFQQLSERVMPKRGCALSLVSNDTLILCGDKFGDVYSMPLFPGDKAVAAPKVAARKMKQNWPAATDLTVHTKGNLQSLQQQKRQYDAKMENPDESSSLKFEHELLVGHVSLLTDLTFVSLPVDASADKKRTYVLTADRDEHIRVSRGPPQTHVIENQCLGHTSFITKLCIPAWAPEYLVSGGGDNYLLVWKWLEGRIVQKVSLVDETSESAPVAVRGIWATSLGGTSNASGALKLILVAIEGSSQLRCFVQESDGTLKTQQSVRASGNILDVTSNGKETILVSVDNVREAGSTQEWRASSSETLVEAYHAKPEADSLVWEPATGSTTTQINSNGTSELEIITDAKKRKEMNDSLYGLGNLRKKNMGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX01</accession>
    <name>A0A2I2FX01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_513192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700449.1">
        <property type="nucleotide sequence ID" value="XM_024855083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX01"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX01"/>
    <dbReference type="GeneID" id="36562789"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513192"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="450" mass="49296" checksum="EE6E040C60B9058E" modified="2018-02-28" version="1">MEYFDKLYGTSYSSAQPPSSWNDYELRDPLAKPQGPKPQRDKEENLLLGVGDIFAGSEPKRRGSTKAKATTMESSLSPLGSSSNQPIRSLPRLNSTRGRRRISKEELEVVLGKAGTTSEKLTGDSETRSETKNIRLRTLSSPAGLRQHGSGDNSGEKPDSRDDTGSNEGETNPREEGDKSDEGDKQDKPPAPAGGGGSDPPDDKDKQPPKDKGKDRAKESDDDAIEPEHDKDKPGPSGDKDKGETEQPDDDDEITPVHDKDNPGPPEDKGKGKTEQLDDDDEITPVHDKDNPGPPEDKGKGKAAAEEEEEEPLSESDIYRPPSDKLNNLPPAEMREMPPRLEGNPYFPQPIVNPANVHRHVRPPKVAPEPNPEYAPPPPEPRLRAAWNEIRRRQRHVVARVLHGPAPGDGLMRDPPSKMPPKRQKPKVKKDKKDDEPPQPPPPPPPPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX13</accession>
    <name>A0A2I2FX13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">P170DRAFT_429864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX13"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX13"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429864"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="166" mass="17692" checksum="2968CD54970519D4" modified="2018-02-28" version="1">MATNTNTSAPGQVFTSADRIRQLNEVDKDVARLIHSAGLAIQALTNARTGDSPTDNSLQSHQARFKEATSQYFALLSSIDVRLRRQVYALEEASILAPDSTSSRAGDTAGTSGAAAGASNPLDISWLNSRKDTVGKDKEAELWAAARGFVEQIGNPGGKQEKMEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX63</accession>
    <name>A0A2I2FX63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative indole-diterpene biosynthesis protein PaxU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_513264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700532.1">
        <property type="nucleotide sequence ID" value="XM_024855087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX63"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX63"/>
    <dbReference type="GeneID" id="36562793"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513264"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF36">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="31655" checksum="EBDC7A6E0558AEFA" modified="2018-02-28" version="1">MSSNSRPDDALAIFTKLSPSIYISEPDANTPNGTESPTIVLAFWMNAPARALAKYVVEYKRLAPSARIVFILSSSNDFLFHHTPQARNARLSPAVQALQASLPTPESPIYLHLFSNGGVFTSTNLIAAYHQATGTQLRISSIIFDSAPGVATVPAAMRAFSFILPRFWLLRICGKALLWTFLILNHWTRKITGSSDAVSIARQAANDPLVVRGAGGKDTPPRYYIYSDADELVNWMDIEAHAAEAESKGWTVRREKFDGSPHVSHMRADPERYWGVVSEHLKSSNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXC5</accession>
    <name>A0A2I2FXC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ras GTPase Rab11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_277933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700564.1">
        <property type="nucleotide sequence ID" value="XM_024843175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXC5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXC5"/>
    <dbReference type="GeneID" id="36550874"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_277933"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="211" mass="23459" checksum="3B0D5A041920E292" modified="2018-02-28" version="1">MANDEYDFLFKVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDSKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHQTYDNVNRWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTEEAKQFASENNLSFIETSALDASNVELAFQNILTEIYRIVSSKAIDGGDSGQAALGERRPVVEISKSQDPEAKQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYJ6</accession>
    <name>A0A2I2FYJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_250334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701013.1">
        <property type="nucleotide sequence ID" value="XM_024843021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYJ6"/>
    <dbReference type="GeneID" id="36550720"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_250334"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21128" checksum="9EDEACF0A405DFEA" modified="2018-02-28" version="1">MVKIKEKFKEGYLLAKRKYREIPNIPEWVSYHRPKIRDERVYDPPEAQEYAGKKALVVGAYGDLGEEIAYRLLLHGCEWIFLASDREDELDNMSKRFQHDARLRSVNPDYQVCWLPLDLRHSDGVINFIHRFLARSNRLHIIIFNAATFHPDYQAILVANNMYTERTIQGISLSSSTVTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYR5</accession>
    <name>A0A2I2FYR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_364969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701069.1">
        <property type="nucleotide sequence ID" value="XM_024844677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYR5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYR5"/>
    <dbReference type="GeneID" id="36552377"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364969"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="48"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="393"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="225"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="86"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB45767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="512" mass="54518" checksum="ED2A2B7D4DB44C16" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYW7</accession>
    <name>A0A2I2FYW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_439533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701126.1">
        <property type="nucleotide sequence ID" value="XM_024849860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYW7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYW7"/>
    <dbReference type="GeneID" id="36557559"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439533"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="265" mass="29303" checksum="65EE3F4F28044C7F" modified="2018-02-28" version="1" fragment="single">MKEWFPSWLLELAAKHNAIIATPNHRLLPESSSTDILEDIEDYWTWLHSSTVADLLSTSVNPTDIDFTRVLSAGESAGGLLSILLALSHPDEIRAATGSYPALDMASDHFGTPSSEPLEPPLPATLVRDHESKIQPGDVFSTGLSMERFQLMIAAIHFGDLGRLYERGTEGQPRGRFYPLEKLDEPDVKIPRGGIAIMHGAQDTIVPLDGVEKFVQKARQVARGKPVEDKIILTVQDGWHGFDLETPLSEPWLTDHLSLVVQAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ06</accession>
    <name>A0A2I2FZ06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LCCL domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_390123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701172.1">
        <property type="nucleotide sequence ID" value="XM_024845893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ06"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ06"/>
    <dbReference type="GeneID" id="36553592"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_390123"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="105"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="584" mass="64083" checksum="9C1B06C87F144BBF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ19</accession>
    <name>A0A2I2FZ19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_478807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701176.1">
        <property type="nucleotide sequence ID" value="XM_024853594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ19"/>
    <dbReference type="GeneID" id="36561292"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478807"/>
    <dbReference type="OrthoDB" id="4074965at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="167" mass="18701" checksum="3CA98E71BA6DC6BB" modified="2018-02-28" version="1">MPVVSRLVSIVLRVAEIICAAVVAGIIGHYLASFNDIDPWPQARWIYTEVVAGLSIILGLIWLIPFSSSFFSWPFDIVISLAWFAAFGILVDAIHKFSCGSIWHWGGITHNNSCSRWKAAEAFSFISAIVWLVSGIVGIWFTFRVRRSTTDAAYTGRRRGFFRRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZA3</accession>
    <name>A0A2I2FZA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mitochondrial ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_414724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701271.1">
        <property type="nucleotide sequence ID" value="XM_024847027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZA3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZA3"/>
    <dbReference type="GeneID" id="36554726"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414724"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000007">
        <property type="entry name" value="Mitochondrial ribosomal protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="225" mass="25567" checksum="2BC0856F6989FF20" modified="2018-02-28" version="1">MATVSPIMRQLGCFRSLLKPQSLTPVQFSRPISTAYSPKPEPAPLPTKIPKSLLSQLPPRMQPNFGRKKLRAYPPPASARKACKDPVNAVAEAQLASLDPTGERKALFDYRRNPRSVKPGDILRVTFKNGDPFAGVCLSIRLRGIDTSFLLRNELTRVGVEMWVKVFSPNVESVEIVQRSDKRKRRARLYYMRQPRHDMRSVENIVSNYLRQKSALAGGRNNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZD6</accession>
    <name>A0A2I2FZD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_512592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701295.1">
        <property type="nucleotide sequence ID" value="XM_024855001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZD6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZD6"/>
    <dbReference type="GeneID" id="36562707"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512592"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="642" mass="71555" checksum="E785C86DE6EED5E9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZR2</accession>
    <name>A0A2I2FZR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1365-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_365352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701406.1">
        <property type="nucleotide sequence ID" value="XM_024844698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZR2"/>
    <dbReference type="GeneID" id="36552398"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365352"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45244" checksum="17CEFFDBF3798AD4" modified="2018-02-28" version="1">MKGPKSLNPLHLARSSARPSISIEYLLLWILSGSLRLGGVYLGLKWTVVAIAVAVLASPNLLIGYLLLASLYPRKLTSVAGTEVSVLGKPLLFPITLTHNRRSPIWNRFSHSVLFVGVPVGIKCQIGKLLSIDADETISSWFTVDSKRYLHRGDDHLGLREKLDVFLRDQNEDPSQWPYAYLLSVPRFLWWERSVVTWWFLYGDNKELDAVIMEINNSFDEKRNVLFKVHGTEAETSALEDSLDTDNLKTQYLDMRRTVESVTSRPTAVYYKGILVKHIYSSPFEKVGEHIAERFMDPTIPAAWDKMRSMSNTTTMTASGRPKMMARMSCHSPPVDPTQTSWFTIIKLLMWWTLPVTLTTARILYQALRIEFKGLMRMMDKPDIRSGSESRRATGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZZ0</accession>
    <name>A0A2I2FZZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_467317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701510.1">
        <property type="nucleotide sequence ID" value="XM_024852474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZZ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZZ0"/>
    <dbReference type="GeneID" id="36560172"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467317"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28488" checksum="5FB2718410FF30BD" modified="2018-02-28" version="1">MLTEEQKPFLDRTNEDESVRGSHVPCSYKTRNRVLVISVISNAVLLPICLLLSAILLSISRLNTHSDRYHGEVEEPYSPANEIIEYEYRSMMKNDTRFRGHPGPEWKQYFSELMSGTLFRISDEELALSGSDSIPLEGDGYAAGLGVAHSLHCVKKIKEFIYHKDIYPGMDETSGEFLYLQDHADHCLDFLRQGSLCNLDYSLYTVYWGARRQDIPTHNVPKVQKCVNWDKLHKWMEGRAASTDELIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G018</accession>
    <name>A0A2I2G018_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_439865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701511.1">
        <property type="nucleotide sequence ID" value="XM_024849932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G018"/>
    <dbReference type="STRING" id="1392250.A0A2I2G018"/>
    <dbReference type="GeneID" id="36557631"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439865"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="305"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="430" mass="46687" checksum="B14F0A9423DA9C1E" modified="2018-02-28" version="1">MSTPIRIAILGGGLAGASLLHALRPHEHLDAHIFESAPAFKEAGMAIGVASNALEALDLIGPSIGQCLQRAGAVPMRGVRFMLAQGPSAGEMFAEVDETDGRQRVTSIVHRAAFLHELLADVSPERMHASKQLERFDTNSDGSLTLRFADGSTHNCDILIGADGIRSTVRKILLGEDDPAASPRNTGAWCIMALKPYALAQASLGSGPVDFENAREYMWIGNGAWIMHNLLNDGQLVQFVVAAHEKDTEGSGRRHRTVGADEIKKLFEGFPPHLVKAVNELLCDQPEQPAMYLWDHPPARTYVSDSGSICIMGDAAHATTPWQASGGGMSIEDTLILSALLGRAKSVSDARTALGVYDKVRRPRTQRIVESSRGTGQIALGLNEEFGLDYEKMKANMLPRWGFIVGFDNEKHRDEALELLARELEAQTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G036</accession>
    <name>A0A2I2G036_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_263129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701547.1">
        <property type="nucleotide sequence ID" value="XM_024843096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G036"/>
    <dbReference type="STRING" id="1392250.A0A2I2G036"/>
    <dbReference type="GeneID" id="36550795"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_263129"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014181032" evidence="5">
        <location>
            <begin position="20"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="9">
        <location>
            <begin position="82"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="6">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="624"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="8">
        <location>
            <begin position="706"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="791"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="957" mass="107652" checksum="C865E806E9649387" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0R0</accession>
    <name>A0A2I2G0R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701772.1">
        <property type="nucleotide sequence ID" value="XM_024849553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0R0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0R0"/>
    <dbReference type="GeneID" id="36557252"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438252"/>
    <dbReference type="OrthoDB" id="3365267at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19730" checksum="00BEB84BA650F478" modified="2018-02-28" version="1">MSESFAAIRSRRSDDLSRLADEHIQQDLQPDDRDALKSAASRVSFWTAFGSAVGVGLGLYTAFRLRSTRHAFFQAFRAQEKPTQIVFADGRTESLPDITPLLKPTTFGDFATYFFASAGGLFLGGELGLAGGAAGAHSTITSDPARKERIEKAFRKFRADVLRKEADSLDSGESVWDKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0X0</accession>
    <name>A0A2I2G0X0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_477391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701813.1">
        <property type="nucleotide sequence ID" value="XM_024853455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0X0"/>
    <dbReference type="GeneID" id="36561153"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477391"/>
    <dbReference type="OrthoDB" id="4419870at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="467"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62370" checksum="699611B1C0529FB3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Y7</accession>
    <name>A0A2I2G0Y7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antigenic cell wall galactomanno protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_427864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701857.1">
        <property type="nucleotide sequence ID" value="XM_024847805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Y7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0Y7"/>
    <dbReference type="GeneID" id="36555504"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427864"/>
    <dbReference type="OrthoDB" id="3438016at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014136553" description="Antigenic cell wall galactomanno protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="19534" checksum="C730B4F7DA343A87" modified="2018-02-28" version="1">MKFFKLFPLAILPFTAFAIPAPDAVSKPALELTDYQLASSLVARQNSQNLSNLGDLLGDLTKSLGAVKDLLSPESLNNIQTLVTDASYLLKQPTAKQTKELIGTVSSLLGSKAVKDLVDQLPELLNDVGGLVTPALVNNVTDILGNAHELLTADFVGNTKGLINDVAPLVSAISQVITALLSSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Z4</accession>
    <name>A0A2I2G0Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_477444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701866.1">
        <property type="nucleotide sequence ID" value="XM_024853462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Z4"/>
    <dbReference type="GeneID" id="36561160"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477444"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014185208" evidence="2">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="212" mass="22453" checksum="6E87AD473EE04766" modified="2018-02-28" version="1">MLSRLYSYILFLTIPPIVAGAGTGSSDPRKCYLMDGSSAPALSPCLPLSSSSSSNNNNSSESKTTHSPCCLLRNTTTIASSSSSNQNGKANSDTCLTPSGLCLSNHGLLYSSGCTDSTWLDPACPSICPDNRSNWTGKALEGKEWSQGQIVEHWQVMVCAAKSVCCRRYSSSVDCCGNQTVRVNEVVVGGLWVGFWALVLVGTIVILGDVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G147</accession>
    <name>A0A2I2G147_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_477488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701909.1">
        <property type="nucleotide sequence ID" value="XM_024853475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G147"/>
    <dbReference type="STRING" id="1392250.A0A2I2G147"/>
    <dbReference type="GeneID" id="36561173"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477488"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="334" mass="38350" checksum="89F3FFF472948385" modified="2018-02-28" version="1">MALYLEQKDIKYLGRKGALTIPSPQFRRELLKSFFLWVQPSVPILDLNVQFHAMVVDEELCGISLLLFHAVMFAASRFVDIDCIKREGYESRRAARECLYRRAKALFELDCEQDRLSHVQAILLMIYWDGPRKGERDAAHWMGSCISLAMSIGLHQDPDPNTMTPAQQRIWKRTWWSMHNHARNTCPDLLSMVSIMEADSPSMVTLDDFELQIASREVRSIFGESEVACSLEYQKTQALLFIEKTKLCQIFQLSTLTGQLSGVVYGDNGIDLETPSTLIDPDELSWWLAQRTPETTHRLPLSPYPMPLLECHKSTLQPVLKIPVKSQRSERNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G198</accession>
    <name>A0A2I2G198_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_477529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701956.1">
        <property type="nucleotide sequence ID" value="XM_024853483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G198"/>
    <dbReference type="GeneID" id="36561181"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477529"/>
    <dbReference type="OrthoDB" id="4493103at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="154" mass="17247" checksum="4A69B229883BB386" modified="2018-02-28" version="1">MSSSSNTPRMSPTTFYRSSSSSSSSSSSSSSASSSSSHSLLSSTRTLAPKQRILWAYMPCRDQPGSTLQRFITARDELNFGFFEVHEKKPDRDFLDKGLLVHVRIDGDIPREGWKEAVRGVALERVKDAIVVEKRKMDKLDGVDKYLKRVEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1P6</accession>
    <name>A0A2I2G1P6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation-independent mannose-6-phosphate receptor CI-MPR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_412109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702107.1">
        <property type="nucleotide sequence ID" value="XM_024846921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1P6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1P6"/>
    <dbReference type="GeneID" id="36554620"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_412109"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000024">
        <property type="entry name" value="Putative vacuolar sorting receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014195008" evidence="10">
        <location>
            <begin position="25"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="35"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="316" mass="34343" checksum="72EC744901AC9A68" modified="2018-02-28" version="1">MKSPTSAILSCLYLLSTPLSSVYAASDSGSKDALSPCVARSPTSGLYYDLNAISLSPPSPNGEKSRKTTRDESWHAKGHDYAANFTLNVCAPVVENITDVVGVEPERWQNVSAYYKKEGNIYSIGQQASEPFFRGRKLVLNYTEGSPCAGEYLGNGSRNKSTIMSFLCDRDAQGSQAIPSFVGTMDDCTYFFEVRSAAACGGIARADGQGLGPAGVFGVIALIAVAAYLIGGCAYQRTVMHQRGWRQCPNFSLWAGMLDFVKDMVVILFSSLGRLLRCRRSPALGNRANGSIHRGRRSSVDAENRLIDQLDEQWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1T4</accession>
    <name>A0A2I2G1T4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_438544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702141.1">
        <property type="nucleotide sequence ID" value="XM_024849621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1T4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1T4"/>
    <dbReference type="GeneID" id="36557320"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438544"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014197835" evidence="8">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="435" mass="48381" checksum="6EED477E877AA347" modified="2018-02-28" version="1">MANKALIPFLVTMMLVTGVCNTILNKYQDMQCVLNCDSPDPKERRTFEQPVIQTAQMFVGEMGSWIVVLLTFLYQRFISPRLSRNNSSPLLAGGYHPVGANDGIDEDDEDGTINGARYSEDPSKPDHLDEQRLPLHGRRIFMLAAPACCDIAGTTLMNVGLLFVAASIYQMTRGALVLFVGLFSVLFLHRKLYLYQWISLCIVVLGVALVGLAGALFDHNEHDVTQENVVMNAAIQARAVARTPEAVQAIIGVLLIAAAQIFTASQFVLEEWILENYEMDPLQVVGWEGIFGFSVTVVAMIILYFSVGQTPAGRYGYFDAKEGWHQVLNNRAVAVSSILIMISIGGFNFFGLSVTRNVSATSRSTIDTCRTLFIWLVSLALGWESFKWLQVVGFGLLVYGTFLFNDIIRPPLKACLPDRMREREVLLPEEPIEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G224</accession>
    <name>A0A2I2G224_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_438639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702242.1">
        <property type="nucleotide sequence ID" value="XM_024849649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G224"/>
    <dbReference type="STRING" id="1392250.A0A2I2G224"/>
    <dbReference type="GeneID" id="36557348"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438639"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="798" mass="87719" checksum="83D1C6012CC15162" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G286</accession>
    <name>A0A2I2G286_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_229994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702286.1">
        <property type="nucleotide sequence ID" value="XM_024842892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G286"/>
    <dbReference type="STRING" id="1392250.A0A2I2G286"/>
    <dbReference type="GeneID" id="36550591"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_229994"/>
    <dbReference type="OrthoDB" id="5341904at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="763" mass="82832" checksum="AC6E0F7F4B75CBFE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2L3</accession>
    <name>A0A2I2G2L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase II subunit RPB9-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_438837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702420.1">
        <property type="nucleotide sequence ID" value="XM_024849696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2L3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2L3"/>
    <dbReference type="GeneID" id="36557395"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438837"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase II subunit RPB9-like zinc ribbon" evidence="9">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="122" mass="13378" checksum="245B50FB18952152" modified="2018-02-28" version="1">MSASPSPSAGGDTKAAEQVHFRFCRECSNLLYPKEDRVNNQLMFTCRTCHVGEPASSYCVYQNKLNTQVGDTAGVTQDVGSDPTVCLPDFCTHCGEEITCFVCGEAPEDARFEDDREEISPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3K9</accession>
    <name>A0A2I2G3K9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_385139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702765.1">
        <property type="nucleotide sequence ID" value="XM_024845707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3K9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3K9"/>
    <dbReference type="GeneID" id="36553406"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385139"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014154584" evidence="2">
        <location>
            <begin position="19"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="118"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="408" mass="44454" checksum="661972E2AB8F899E" modified="2018-02-28" version="1">MVALQVLSLGLLASQAWAMPAASQSSATPTLPSSASSSTAVAASQLDQLADFAYNVTTDSVGGGSESKRGGCSLQNLRVRRNWRAFSKSQKKDYINSVLCLQKLPARTPAHLAPGAKTRYDDFVATHINQTLEIHYTGTFLAWHRYFIYEFEQALRNECGYTGDYPYWDWGADVNSMEQSPVFDGSETSMSGNGAPIPSQPDVKLYLGDYPAIDLPPGSGGGCITSGPFKDYRLHLGPAVLSLPGGNTSTVDNPLTYNPRCLKRSLTTEILQRYNTYPKIVDLILGNDAVWDFQMTMQGIPGSGSIGVHGGGHYSMGGDPGRDVYVSPGDVAFWHHHGMIDRVWWIWQNLDLPRRRNDISGTGTFMNNPPSPNTTLDTVIDIGYANGGPIAMRDLMSTTAGPFCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4U6</accession>
    <name>A0A2I2G4U6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_199894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703203.1">
        <property type="nucleotide sequence ID" value="XM_024842756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4U6"/>
    <dbReference type="GeneID" id="36550454"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_199894"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23681" checksum="C85C53A7A30D5498" modified="2018-02-28" version="1">MARPSSRPVTAASDHHGIRDTLGKRPGQDQGKMERTRDGDAEGRGKKLPQPAGYGVRPRRTGLLRFSARKNEPETSSQQAGVIEEKSSPRHSWGVKQKIFSAIRPDKWQRCPRRGKEGPAFPRNHPTTVSFLQAVVLRLLFVEFWTDFSAVLTPPESMRPNPMLIIYRPDLSSRGNTTLSTTSSVVLSFFSFFFSILFFSLYFPQSPDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G591</accession>
    <name>A0A2I2G591_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_204622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703348.1">
        <property type="nucleotide sequence ID" value="XM_024842779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G591"/>
    <dbReference type="GeneID" id="36550477"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_204622"/>
    <dbReference type="OrthoDB" id="4486482at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="312" mass="34951" checksum="30344F71E934B1BC" modified="2018-02-28" version="1">MSVTIRSEIVDLDGLIPRAVGKEYEDMDVAGLIPWVFRNSDVATKECTGKWPQDELSFRAFFYDLGSYFNGLQGPNVGIMDFLTALSTINLPKTSWEVPGRESHKTFIRSQGLILKALVRTIYFNLEYVGEPIPRVKFDSEVMQKYVMGGKRFASKSEGAATVKLQEGHVPILSFTGWYEGQTWDQFLAETLSIMLGQLAKNITLHSGHAGPQDQEVFVVGFHGRYVHIAHGLFLADTIMRVHSEGCTADEVFALKFSRGYDLCLKEDWLEAMRALARLFRYLFSGNAKVGAIQAYLETRRAAAAAKMGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6L8</accession>
    <name>A0A2I2G6L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_438107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703824.1">
        <property type="nucleotide sequence ID" value="XM_024849511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6L8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6L8"/>
    <dbReference type="GeneID" id="36557210"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438107"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="328" mass="35951" checksum="77B29A9C2D7C17E4" modified="2018-02-28" version="1">MVNIWTQRMNMSFFNKIASITGKTVLALALYKTWRFISLHLVLYGDRNLDRYKSKTQESWALVTGASAGIGYAYAEELVSRGFGVILLGHKPDELQQAESKLKSMPGQPKIKLITLDAITATPAEIDSALDPVKEMHLSILINNVGGVTAQPSFKSFVEYSATEIEAIINLNARFMAHVTHILLPSLKRNGPSLVLNMSSGSHMGMPWLCMYSAVKGFNASISRAISREAKALGMAIDSIVVYPGDVQSQANTHGLAPLSPTASHYAKVTLDRVVTAVRQGRNELNPFFLHGLSGLLDFVPETLFQKLVEGSIAEKVRVYGELAEKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G734</accession>
    <name>A0A2I2G734_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_328581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703982.1">
        <property type="nucleotide sequence ID" value="XM_024843353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G734"/>
    <dbReference type="STRING" id="1392250.A0A2I2G734"/>
    <dbReference type="GeneID" id="36551053"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_328581"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="101" mass="12079" checksum="3CAF2C327C0C16E3" modified="2018-02-28" version="1" fragment="single">EHLVILPDRPNVLARRVEIRPRHSPNFLRLHNEGYVSWAGPVFDDHVDTEIARRPFKGSVMVVNEQSWKEFHRAIESDPYVREKIWDLEKTSFIPFRTLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7C3</accession>
    <name>A0A2I2G7C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_358663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704067.1">
        <property type="nucleotide sequence ID" value="XM_024844309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7C3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7C3"/>
    <dbReference type="GeneID" id="36552009"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358663"/>
    <dbReference type="OrthoDB" id="4232626at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="116" mass="13145" checksum="26AFBD3213E2FFDB" modified="2018-02-28" version="1" fragment="single">KHYGLRKSHLMKLISYVDAGGKLDSHDEVPEGIRQALYVEAQQKLERASNKTNNQVALGAPYPININLLAPQDDAVKAYCEWHELQVTDEKRKADWRKACNITLSNGLDLELVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Z6</accession>
    <name>A0A2I2G7Z6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_383518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704296.1">
        <property type="nucleotide sequence ID" value="XM_024845642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Z6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7Z6"/>
    <dbReference type="GeneID" id="36553341"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383518"/>
    <dbReference type="OrthoDB" id="4579491at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="451" mass="51733" checksum="2C543343B0D9A159" modified="2018-02-28" version="1">MRWSCQRLFSALSSRQAYTCLATKRLQVYGIPTATQFRQARNIPTRKNFTTESTKSSSTRFTVQVRGPEETEYDDHRDLLLAQLKKIPRDTQFLEITEDTPSSIEWGLLGNHFNRIKDLEMRVGFNEELNDAELPDHWPLERLFISNACAEVFRSPFVLEGRVKHLVLLATAGLRFEGLSTDELCSANREAIARGEKKAQYVSEKKRMQIVSIPELVVEMMNKRWAGTHSPLPPTTRNTDLQLLPKEVPTKMTKLEIIENDSMDTFNRMTVALPHVIENLSTLNIRSTQGLDFAFTKETLFTCLLPQLSALKTLVLSVGEVFQDDSLLPTLYSVLPPNLSTLRFRGPASLVESSHWSNWITSFASPEILPNLKRLSFALDLHYEASGESSADARRRKLVKAPEDVLRCAQNECKRLFRAAEQRGVVVEPFRDEWVEEWPYLKQVDERWMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8Q4</accession>
    <name>A0A2I2G8Q4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_384003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704568.1">
        <property type="nucleotide sequence ID" value="XM_024845664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8Q4"/>
    <dbReference type="GeneID" id="36553363"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384003"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="93" mass="10009" checksum="4066A2A58190DCC2" modified="2018-02-28" version="1">MAGNFTDHARNLRPSPIRPGTNGAPVPCRSSCLGSANPRRPPRSSCLRSLAALVARSYHPDVVSPHHLGVVLGQWVIYLLLLSIHPRLPADTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8Z5</accession>
    <name>A0A2I2G8Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_436930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704651.1">
        <property type="nucleotide sequence ID" value="XM_024849254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8Z5"/>
    <dbReference type="GeneID" id="36556953"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436930"/>
    <dbReference type="OrthoDB" id="4338083at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014182452" evidence="1">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="142" mass="15687" checksum="A9CE185D48798800" modified="2018-02-28" version="1">MRSFLLLSALLLGAAAVPTSTSSNPEFEILKYRNWDLRFSQPGCSPNRTGLSISLLHRSGVGTRDCVSLLTEVGPHGTTIDLSEVDSLSWKAKRENGKHDLCLYASDDCSDKEAMALRNGWEVCLKYEGWQGYRVVEKGDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G949</accession>
    <name>A0A2I2G949_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P170DRAFT_384232</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704703.1">
        <property type="nucleotide sequence ID" value="XM_024845672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G949"/>
    <dbReference type="STRING" id="1392250.A0A2I2G949"/>
    <dbReference type="GeneID" id="36553371"/>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
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        <property type="entry name" value="P-type_ATPase_IV"/>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
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        <property type="entry name" value="ATPASE_E1_E2"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="517"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="549"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1075"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1101"/>
            <end position="1123"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1153"/>
            <end position="1171"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1183"/>
            <end position="1202"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1209"/>
            <end position="1230"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1242"/>
            <end position="1263"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="1041"/>
            <end position="1269"/>
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        <location>
            <begin position="1"/>
            <end position="135"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="332"/>
            <end position="387"/>
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        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
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            <begin position="98"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="20">
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        <location>
            <begin position="364"/>
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        <location>
            <position position="612"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="612"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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            <position position="614"/>
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        <ligand>
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            <position position="762"/>
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        <ligand>
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        <location>
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        <ligand>
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        <location>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
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    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB49401.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1277" mass="140604" checksum="C298D993031C649A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G959</accession>
    <name>A0A2I2G959_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fad NAD binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_384260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024845674.1"/>
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    <dbReference type="GeneID" id="36553373"/>
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    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="409" mass="43399" checksum="50A0D1CF1AE1B61F" modified="2018-02-28" version="1">MSTANERRDIVIVGGGIIGCCSAYYLTRHPSFDPSRHSVTLIEASEIAGGASGKAGGLLAQWAYPSNIVPLSYKLHAELAKEHGGKDRWGYREVNCGQLIAKGRPLNEKKEAPGGEAGSSVSLQKRSADALGKLKSARVPQDLDWIEPELLRGYESMSDPGETAQVHPYLFTTSIAKLAEEKGANITLGSVSSIGYSGDAVESVSYTDKKSGEAHTIPATDVVVAAGPWTSSILPDAPISATRAHSVVIRPTRPVSGYTLFTNIEIPANFDPAKPSRPTVAQPEIYARPDDTVYACGEGDHVVPLPATTADVEVDEKRCQDIINEVGSVSDELRDGQICARQACYLPNVTMRGGPLVGHAGAKGLYLAAGHTCWGIQNAPGTGKVISEFVFDGQAKSAKISSLDPRNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G962</accession>
    <name>A0A2I2G962_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial cytochrome c oxidase assembly factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_437004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704729.1">
        <property type="nucleotide sequence ID" value="XM_024849268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G962"/>
    <dbReference type="GeneID" id="36556967"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437004"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11341" checksum="9D7F16FB9C565A70" modified="2018-02-28" version="1">MSSILRRLQGGNLEVFKFGMYIIFPIGWMYYFGTNLDERFTVPGFWPTTEQSHKIPLEREEIDAELSRMRTVDAVKRQRRQAQAQAEAQAAANAQNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9H3</accession>
    <name>A0A2I2G9H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_186086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704827.1">
        <property type="nucleotide sequence ID" value="XM_024842693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9H3"/>
    <dbReference type="GeneID" id="36550391"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_186086"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014188033" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11880" checksum="5D9E93C002E85890" modified="2018-02-28" version="1">MRIHSFSHPCLSLLICFFFPALPCYNSYCCYVQFYPFYSGDHIYLSFAGDEAICFLSPKEHDPSLSFHFISFLFVFPLINCTFDLYFRALHEVYWITSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAH3</accession>
    <name>A0A2I2GAH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_445323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705181.1">
        <property type="nucleotide sequence ID" value="XM_024850693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAH3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAH3"/>
    <dbReference type="GeneID" id="36558392"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445323"/>
    <dbReference type="OrthoDB" id="192702at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021276">
        <property type="entry name" value="DUF2855"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11017">
        <property type="entry name" value="DUF2855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="402" mass="44497" checksum="72B29A4FE2E85615" modified="2018-02-28" version="1">MQIHAVSKSNNADHSTITLTPSLNPLSPALTSSNLSYARAGHFIRWWDTYPLPSNSPAPYNNQAAWGIVLAWRYGIVLESTTSIQPGTQTWGFWPTADTPVDLNLTPGQSSDHWIETSVHRQALMPLYNIYVVTNEKDKERMAWSAVFDGIWRAGYLMSEYVLNPQRPIHPLGDSAGLPWTAEDADISEAMVSALAASTKTARSFVYNLARRSTGSPLGLVLVSSSPGPLVYPVANAAFSVHAISYDELAKSAEWLGDRKPKKLVVLDFGPRGDGLNQLCDVIERTEELEMSKRVIIQIGSQQKVYTAEELQASRHAMVTKSKIQYNTSGVQDTLLQGDNPGDYLTPVDERWGQWLNDRAVAVPDMRLVWRQGIDGPQGIHGGWERLCRGDVGSDECLVYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAK3</accession>
    <name>A0A2I2GAK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_133501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705207.1">
        <property type="nucleotide sequence ID" value="XM_024842427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAK3"/>
    <dbReference type="GeneID" id="36550123"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_133501"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014164262" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="9">
        <location>
            <begin position="94"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="392" mass="42791" checksum="83934C48D5F16310" modified="2018-02-28" version="1">MNINSWLITFALLCRQVMAQCAELPPLSDLRLISTLPDPFSWYPLSNPDRVATKEEWECRRQHISSLLQQLELGTKPPVPANATTSFSQNKLSITVSEGSKRITFDVTIDLPSGGGEGPFPAMIAYGGLSLPLSSGIATITFDNGLIAQQTDQSSRGKGLFYDLYGSDHSAGALMAWAWGVSVLIDALASTPSARIDTTKLGVTGCSRNGKGALVAGAFDPRIALTVPQESGAGGSGCWRLCETENAGSGDVQTARQIVQENVWFSTDFDDYVDQVESLPFDHHMLAGLVAPRALLSVDNVGYEWLGPWSSLGCMGTARRVWEALGVSDRMGYSMSTDHSHCLFPDQQREDLDVFVRRFLLGEDANTTVEKNYPGIEFESERWVDWDVPVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBR9</accession>
    <name>A0A2I2GBR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_508528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705630.1">
        <property type="nucleotide sequence ID" value="XM_024854584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBR9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBR9"/>
    <dbReference type="GeneID" id="36562290"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508528"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="186" mass="21231" checksum="56B107E5758A8F45" modified="2018-02-28" version="1">MIDICVYASVDGDAELSASMTKFSNIAPTQTVNHTDYEPISIRPLLLSIETKKPGVHWDTAQLQIGSWHAAQWSFLRWAVGQKIRRQRAGRYTDIHHMNEEEEAYKVNELTVLSSLGVIPSVIIQGHRWLLVLSTYEKGKTKLWTDQQFGTTQSCLDIYAAIASMRQLTAWARDVYMPWFKTSVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC94</accession>
    <name>A0A2I2GC94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_353527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705806.1">
        <property type="nucleotide sequence ID" value="XM_024843984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC94"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC94"/>
    <dbReference type="GeneID" id="36551684"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_353527"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="371"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="704" mass="78298" checksum="890BE511C655D9FA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCF4</accession>
    <name>A0A2I2GCF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_148168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705854.1">
        <property type="nucleotide sequence ID" value="XM_024842503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCF4"/>
    <dbReference type="GeneID" id="36550200"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_148168"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014175396" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7986" checksum="469AB584918F65A1" modified="2018-02-28" version="1">MMNATEFGFFFAFAFYFFLLLSSSLGDDLLPGINWIGSLHPPGRSCLLSVESTRAKEHDGNPLEQVTTTKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEH0</accession>
    <name>A0A2I2GEH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_509305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706600.1">
        <property type="nucleotide sequence ID" value="XM_024854662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEH0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEH0"/>
    <dbReference type="GeneID" id="36562368"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509305"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="327" mass="35906" checksum="1DECB0F78C05FDD6" modified="2018-02-28" version="1">MTRTILVTGATGQQGTSLIAALRPRDTDSADYRVLALSRSKTSPSAKHLVQEKHVTVVEGDLNDRVSIARVFQEARDGDGTIWGVFMVLAFPGLGKNADAEEAQGKLLADVALEYGVSAFIYSSALRSGPKYDDQLERSGKAKVNVERHVKEIGLPWAIVKPGFFMENFSGMLGPLAVHLMKAGMKPETRLDLVAAQDIGRVVAAVFKDFSNCSSREVIIVSESLTASQIERTYRPTTGLVGSYVSPCLARLVLKINADTQNLVQTINDTYDRSINGDYPEREDEIQLAKDVCPQRTTFHEWVSKADSEVQEGWNRVSIWGLLTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEJ0</accession>
    <name>A0A2I2GEJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_163680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706574.1">
        <property type="nucleotide sequence ID" value="XM_024842582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEJ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEJ0"/>
    <dbReference type="GeneID" id="36550279"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_163680"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="761" mass="85457" checksum="240BD8FB97FD91D9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEY2</accession>
    <name>A0A2I2GEY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_311524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706713.1">
        <property type="nucleotide sequence ID" value="XM_024843250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEY2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEY2"/>
    <dbReference type="GeneID" id="36550950"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_311524"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="317"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="512" mass="56412" checksum="0CFEB8B665EF6492" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFH2</accession>
    <name>A0A2I2GFH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">P170DRAFT_400975</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Fatty acid synthase is composed of alpha and beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 23">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706932.1">
        <property type="nucleotide sequence ID" value="XM_024846355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GFH2"/>
    <dbReference type="GeneID" id="36554054"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400975"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 23 26" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 23" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="28">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="29">
        <location>
            <begin position="1006"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="24">
        <location>
            <position position="1192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1653"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1654"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1655"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1752"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1753"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="26">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00065422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="PLB51630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1767" mass="195290" checksum="1A1DEE13533E20AA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFK7</accession>
    <name>A0A2I2GFK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_82410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706965.1">
        <property type="nucleotide sequence ID" value="XM_024855399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFK7"/>
    <dbReference type="GeneID" id="36563106"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_82410"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="385" mass="42620" checksum="FDD10981BBED47EB" modified="2018-02-28" version="1">MGKPQPQDLQNDSPELPPPSYEDAIIQPSSSSAPPSAPYPVDPPIPSQQPYLSINANTRACHQVTLSPSLSSDASALHALITRQADVPARPQLTIRGTHTVTRSENHGRKHRSRNITDFDFKVDLSPYVVGPAGPDGDADEGWHELKVAADGDGAKRYRGGIFRSRRWKGHGCCGRRGAIRLSDGRGEAPGLIGWCDRFCEDPAPVKSFTFTRTVSGLDSEIIRSALKSHLRALNYRGKVEVSTSIANNSITIYSPHWINQARNNSWIFYGCLLLQLWIVAWPVLWLLERKYRVVESEWRFSRPSGASGKTFAAGRSEAEVAKDVAPVVTQAAWEKRRAGKVLTPEEVDTLRRLELEGRQRGGRVMVVNFGDMGEWGNNHYTFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFW9</accession>
    <name>A0A2I2GFW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="9" type="ORF">P170DRAFT_471704</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFW9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471704"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="256" mass="29185" checksum="68D2C0238D97BD0D" modified="2018-02-28" version="1">MAVGKNKRLSKGKKGIKKRTVDPFSRKDEYSVKAPSTFQTRDVGKTLVNRTSGLKNANDSLKGRIFEVSLADLQNDEDHAFRKVKLRVDEIQGKNCLTNFHGLDFTTDKLRSLVRKWQSLIEANVTVKTTDDYLIRLFAIAFTKRRPNQIKKTTYARSSQIRAIRKKMTDIMQREATSCSLAQLTTKLIPEVIGREIEKATQGIYPLQNVHIRKVKLLKSPKFDLGALLNLHGESATDDKGHKVEREFKEQVLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG27</accession>
    <name>A0A2I2GG27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multidrug resistance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_506758</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707134.1">
        <property type="nucleotide sequence ID" value="XM_024854414.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GG27"/>
    <dbReference type="GeneID" id="36562120"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506758"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="110"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="435"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="778"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1102"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1347" mass="146882" checksum="6E75F41A1FD626AF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGC3</accession>
    <name>A0A2I2GGC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_93904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707235.1">
        <property type="nucleotide sequence ID" value="XM_024855441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGC3"/>
    <dbReference type="GeneID" id="36563148"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_93904"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="18436" checksum="89B916DF7591DE72" modified="2018-02-28" version="1">MPENCFSLGLSVLPARGSFHFPEEDRYHLPSASLQTCGYGFYCFLYPSLFFEVNAAIVFPSLCMSFVLDETAVLAISWGRFKKASHVASRGRLMRPFRGLSTRQKKAVRSTRAPSSIGLNTRSHIQCDPILTHDYPDQHIATVELRRQPGQITARRLLRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHG5</accession>
    <name>A0A2I2GHG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_434109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707616.1">
        <property type="nucleotide sequence ID" value="XM_024848646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHG5"/>
    <dbReference type="GeneID" id="36556345"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434109"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="2">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="215" mass="24130" checksum="6333EEB79D13D115" modified="2018-02-28" version="1">MSIPLQSEKDTDTIDQPPPANYSLRQPDWMSKAELAQLAAGMPQDDVLETFEYVQEELNRFLESQKQREAQAAEATNASSGREGPIVRVWFYFPSLSTRKKRDDMVNNAPAYSLTGFVLAGKPGVLCLEGASSDIDAYMSFIKTHSWGDIPSHQKKVSERFREKDGVERVFSGMEEITDSLGERGGQRANRGDMQALEAWLDARGLQEAFEKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHJ8</accession>
    <name>A0A2I2GHJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_378054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707658.1">
        <property type="nucleotide sequence ID" value="XM_024845431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHJ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHJ8"/>
    <dbReference type="GeneID" id="36553131"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378054"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="114" mass="13054" checksum="BDD5D2AA0AC2FAC6" modified="2018-02-28" version="1">MSIENLKTFDPFAEADEDTGETKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVNDTEMGDVIQLQGDQRKDVQEFLTDKKEGLELDAKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHW1</accession>
    <name>A0A2I2GHW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707775.1">
        <property type="nucleotide sequence ID" value="XM_024852940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHW1"/>
    <dbReference type="GeneID" id="36560638"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472365"/>
    <dbReference type="OrthoDB" id="4442753at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="161" mass="18710" checksum="F632C1A52F40378A" modified="2018-02-28" version="1">MAPRLAYLVKGIMSFKTRGRKNDVSDDQDDQTPLVEKQDDKPPTVEEQGKEAPTVKDQDKKSVCHEYEVFVHTPNPNLSPRQEIEFFLDKVKEGRVEVIKKKYDYLLKDRRGLCIYVTHKSRRCEDVVECIRCILESTKRDPGIDHCKLIRHCPRLPGEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIA1</accession>
    <name>A0A2I2GIA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative unusual protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_378554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707911.1">
        <property type="nucleotide sequence ID" value="XM_024845452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIA1"/>
    <dbReference type="GeneID" id="36553151"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378554"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="160"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="654" mass="74632" checksum="8F72BA2553C4A964" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIE0</accession>
    <name>A0A2I2GIE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_507373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707919.1">
        <property type="nucleotide sequence ID" value="XM_024854478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIE0"/>
    <dbReference type="GeneID" id="36562184"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507373"/>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19273" checksum="63A7D81283C38CEC" modified="2018-02-28" version="1">MTLKPLVLSRIHTLCTTFSDPSSSLPSLLSNFTTSEPWAFEHGLPALAPFLGRKFSGIEGLTRYFTLLAETLEIEWMRVEGEEGWVVDVDVDGDSHGIMKVSLRGEARFRWKSTGQAWEEGFAYRIGLVDEGEGAGAGAGAGAEGDGNRVKVKEYEVWADTGAAYLARKGELDRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIN1</accession>
    <name>A0A2I2GIN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_462609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708038.1">
        <property type="nucleotide sequence ID" value="XM_024852110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIN1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIN1"/>
    <dbReference type="GeneID" id="36559808"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462609"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="119" mass="14117" checksum="2E3CC350B9DEB4DE" modified="2018-02-28" version="1">MPQDMPPSGGYGPVQYKRNIPARGFRPVYYLLGMHMFMAYGMYKLFYGIREQNELAREKIWGRLHLVPLLQAEEDRDQVRRHYADKAREKELLGSETKVYHSDRFVRPTFAYMPSKVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIV3</accession>
    <name>A0A2I2GIV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_507540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708100.1">
        <property type="nucleotide sequence ID" value="XM_024854495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIV3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIV3"/>
    <dbReference type="GeneID" id="36562201"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507540"/>
    <dbReference type="OrthoDB" id="4344093at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="348" mass="37846" checksum="96F351236BE3A7CF" modified="2018-02-28" version="1">MAYASNPAPPILAHSLLTESEPGNKIDSEKSVDADDRTSLSGTWNLQDDIDSGFQCPPKGLFRNGVVIGISTLRSQQRNGNDDEFTGQFPRLLLSAYLHKRPKSPTPFPRAIIIHPATFEGFSPRNLLSSLLAPSQTPQLTREEAIACLDSVQLFPVYDVAAAVQAISEVSNLLDRSEEERSQTHNSERPPETETTTHPSVLLIIAGLDTLAEGAVRASNTVRGAAILTTALRSLTQLSRLHGSFLSVMLVNTGGLGSSGAFSNNANNAQQTNPRRDVGFSYQDDGIHSIFHTSETPLLPSLLMRTLDQGIDTHLLLSRSRTATVVEVIKDRVGEGIGKWCIWDRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJT0</accession>
    <name>A0A2I2GJT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_379590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708434.1">
        <property type="nucleotide sequence ID" value="XM_024845490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJT0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJT0"/>
    <dbReference type="GeneID" id="36553189"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379590"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="347" mass="40805" checksum="9855DF25EF03C20A" modified="2018-02-28" version="1">MPLHLLGKKSWNVYNPENIARVRRDEAQAKAREEEQERLMQEVDAERRIQVLRGERPSTPPPPPRSPSPISRPEKKSHTDDLGRSRKRRRLAGENDTDRDIRIAREDAQYALAKREELASSRTSDAPLEDSAGHINLFPSNESKRPVEKNAEAQKESADKQRSYEDQYTMRFSNAAGFRQSVGQKPWYSSSGTEAMAPDSVSGKNVWGNEDPMRKEREKSRMDANDPLAAMKKGVRHLKSVEQERRKWNEERSRELEALKAAERDRPRHRRRRSRSEDSLEGFKLDASPERHREDKDRKSHRHHRHGRDRSRDRSHRSRHHSDSRSHRHGRDHHRSRDESRRHRDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJV6</accession>
    <name>A0A2I2GJV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_473040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708466.1">
        <property type="nucleotide sequence ID" value="XM_024853005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJV6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJV6"/>
    <dbReference type="GeneID" id="36560703"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473040"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF61">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="681" mass="75365" checksum="3C67A2EF48C3ABA8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJX1</accession>
    <name>A0A2I2GJX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_462945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708472.1">
        <property type="nucleotide sequence ID" value="XM_024852126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJX1"/>
    <dbReference type="GeneID" id="36559824"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462945"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB53170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="680" mass="76337" checksum="9F2E820C643117B1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKL3</accession>
    <name>A0A2I2GKL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mismatched base pair and cruciform DNA recognition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_400640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708724.1">
        <property type="nucleotide sequence ID" value="XM_024846335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKL3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKL3"/>
    <dbReference type="GeneID" id="36554034"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400640"/>
    <dbReference type="OrthoDB" id="5309565at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="179" mass="18866" checksum="18DAD710967DA7DB" modified="2018-02-28" version="1">MSSENSSENPSTLKSYVDSATGLAQRAMGTVTGDSSTKTEGETTQSTASAENTASHETAKLGPVTADPHTGATATDHPQRNTGNWDQTIGSAKESLGNLTGYEGLRREGVEQNSRGKAAEAEGQLRDFGSGLKDRAQGGLGKVAAAAKGDREEEAEWERMHDQGKVQQRGAEVDMQKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLE9</accession>
    <name>A0A2I2GLE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_460084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709010.1">
        <property type="nucleotide sequence ID" value="XM_024851906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLE9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLE9"/>
    <dbReference type="GeneID" id="36559604"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460084"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="144"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="359" mass="39185" checksum="E4A7B876240C3D62" modified="2018-02-28" version="1">MGSILPTDQVLNIAVAGLGRMGKRHVHTLVGRVPRAKVVAVCSTWDNEVEWAQEAYQGTGIQVFNSYEDMIQLPSLNAVWISTSTDVHASQTLAAINKGLHVLCEKPLSTDLTEAQHVVDVANAHPHLKVMAGYSRRFDASYRAAKEQLAGIGAPFVVRSQTCDLLDDTGFFVRYAARNGGIFVDCCIHDIDLSLFYMGEHLLPKSAFAVGSLQHHPELGPLQDVDNGVGIVEFWGGKIAYFYCSRTQAHGHDVCTEITGTHGKIMVNLIPRTNHVQVAGANGISHAVPEEYWQRFEDAFATEANEFVASVLDDEPVPVKLELGVKGIIIGRALQDSLLSGEVVKFNEKGQRLDGKNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLP3</accession>
    <name>A0A2I2GLP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_431608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709098.1">
        <property type="nucleotide sequence ID" value="XM_024848073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLP3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLP3"/>
    <dbReference type="GeneID" id="36555772"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431608"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="344" mass="38942" checksum="2BDD9211FBD81379" modified="2018-02-28" version="1">MKYVQLGSSGLRVSPICVGCMSYGTPGKQFDWSLPEDEALPVLDHCYRSGLNFFDTANVYSNGDSEVILGKAIKKYDWRRESLVIATKLWAPVGRGDEKPLRMSVEDRDNAGYINQYGLSRKHIFESVDASLKRLDLPYVDLLQIHRFDPNTPPKETMEALHDVVKSGKVRYIGASSMWAHQLLEYQYTARIHGWTEFISMQNVYNAIYREEEREMFPACTKFGMGTIPWSPVAMGFLARPWNSFSETTRGNSLNNNFMGQPLTETDKKISAKIEEIAQSRGVAMAVIALAWCLSKPFVTSPIVGMSKNERVDEAIQAIDFQLSEEEIKSIDDLYEPKRVVGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM54</accession>
    <name>A0A2I2GM54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_396957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709258.1">
        <property type="nucleotide sequence ID" value="XM_024846146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM54"/>
    <dbReference type="GeneID" id="36553845"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396957"/>
    <dbReference type="OrthoDB" id="5381672at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="415" mass="46664" checksum="EBACA305D93414BD" modified="2018-02-28" version="1">MTHFPRKGRQSQQQREPLQPRSPPDRNTFAFRPRAYIVILVLVYGALSLTSWCILCTLSWRPLGKSNYEFGPLVETELESIKHQVSKWSQASRVVSGVVGVLTLPLTSSVCAFAAVNFTQPRTWGGKSSLTLNQTVTLANKGWTSPLVLFTLPFKFKSIGSFYLYYAIALHNIGGILSPLQQLVLDQEEIHTLINYPVQKMGLLEPPRLVIQNFPREEVALLRAILNSARPTDLDLNLWQDQDSNSAASPFVSMAPSNIDTKGIRQFAPRLNSSMRQETLQKDDFPSDCSGNSFFRNYTLPAGSLYTYQHISVCMPGDLSISPFRRTRDKYDFDEVLYLKVKTDAYNGDWITRKLILSTTVGYFELPNSLNGNKPGPLQPKDPIKSCPNPPCEPQIQGLVLICLSSYFHLQSSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMB1</accession>
    <name>A0A2I2GMB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_372645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709333.1">
        <property type="nucleotide sequence ID" value="XM_024845209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMB1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMB1"/>
    <dbReference type="GeneID" id="36552909"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_372645"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="709" mass="79828" checksum="FF170E39E969F5F6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMK8</accession>
    <name>A0A2I2GMK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_372792</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709419.1">
        <property type="nucleotide sequence ID" value="XM_024845214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMK8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMK8"/>
    <dbReference type="GeneID" id="36552914"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_372792"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF14">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE HST2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB54117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="340" mass="37162" checksum="1200F125475EB61B" modified="2018-02-28" version="1">MESTSNAQSSSETSSNINTLAHLIQTGQAKNIIVIAGAGISTAAGIPDFRSPTTGLYHKLAPLKLPYPEAIFQLSYFKHTPEPFYAIARARHPRNLKPTISHAFLALLAKKGLLEFVFCQNIDSLELDAGVPSDKALSVHGNWKSQRCSTCRKPYPGYLMKQAIEKGEVPYCLHSGCGGAVKPDVVFFGESLPAAFDVEVKRLPKADLVLVMGTSLKVHPVAGLPRQVAKGVPRVLINNERAGDIGYRESDMCILGSCDESVLKVADALGWKDELEGLWQDAMARKEQEEPYDGPELDELIERLAAKNKDRMVSEGHQSMLEKHLASKFAGVLREKPNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN39</accession>
    <name>A0A2I2GN39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YT521-B-like splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_12890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709597.1">
        <property type="nucleotide sequence ID" value="XM_024842395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN39"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN39"/>
    <dbReference type="GeneID" id="36550090"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_12890"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="301"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="427"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="69600" checksum="A32C48267B695729" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN46</accession>
    <name>A0A2I2GN46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_347203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709609.1">
        <property type="nucleotide sequence ID" value="XM_024843613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN46"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN46"/>
    <dbReference type="GeneID" id="36551313"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347203"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="6">
        <location>
            <begin position="102"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="326" mass="36093" checksum="8F1DAF2743E65EB0" modified="2018-02-28" version="1">MADPASEMHNTHSPSLIATLHFAQQAPVILNRQAHLGKKPLLSLISKKETFDDYGAIEQLFFSCLQSGDDKSALLCLDQLTLRFGSSNERVMGLLGLYEEAVAENKPSLDACLQKYDHLLSENPVNLPILKRRIAVLRSLDRPALAIASLIDFLKAVPTDAEAWCELAELYQSQGLSAQAIFSLEEALLIAPNAWNIHARLGELLYIDASSSPPEISTRGLYRSMQYFCRSIELCQDYLRGFYGLTLVTSDLIGKGSPKDNPADAQPIPVEDSPPSKDTVERLNAFAKRGLEAIISKRPMDHSLWEHAQGELIAAKELISRMPDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPK9</accession>
    <name>A0A2I2GPK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_24990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710101.1">
        <property type="nucleotide sequence ID" value="XM_024843017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPK9"/>
    <dbReference type="GeneID" id="36550716"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_24990"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="176" mass="20346" checksum="8FD1E484873D15B2" modified="2018-02-28" version="1">MGAKDESRRVIGVSDSTPSLGFLLVVLFWLWFSKVRDFYTRPSHCHPSLFPLSRLCWFVSALRRFASTLRYRTRIRYRKYPSWCRRAAFMHSCIEPPAHVLYGVCWNDRNYGSSLAFLSSWQACPPCHSSIHAASAENRRRNGCDGNIVHMGGWQGDRVYGCARSFCHSISWSVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ49</accession>
    <name>A0A2I2GQ49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF2 family helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_505639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710307.1">
        <property type="nucleotide sequence ID" value="XM_024854306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ49"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ49"/>
    <dbReference type="GeneID" id="36562012"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505639"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="899"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1195"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB55005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1207" mass="135537" checksum="09D19DC693996397" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQE7</accession>
    <name>A0A2I2GQE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_398991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710405.1">
        <property type="nucleotide sequence ID" value="XM_024846258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQE7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQE7"/>
    <dbReference type="GeneID" id="36553957"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398991"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000475">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="52"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="508" mass="55828" checksum="19582DF880DD8545" modified="2018-02-28" version="1">MSEIHKSPIVVDKDVLEPYLSEFRLQVACDGIHIQWAKGNPRHPRNWSLLRKVHDASLIIFLELFTTAISTAGSTTAHYAAGEFGIRKELSIFLFVSIYLLGQGIGAIIFPPYSEAFGRKNLYIVSTALYSVACVIVASVHCLSGVVIGRFVSGFLSAIPTTVVMGSIEDMFNSKDRVWMVCCWAVVSNLGLIVGPIMSTFVTADLGWRWLFYLATIVTGGLALLLLGIRESRPSMALAKEVAKLRKATQIETLEGLNPDETPDWQTFVRIALFRPARLFFTELIVFIVSIMSAVAIALVYLFTEVLPPVYEEFGFSPKQACLPFLAIGIGLAFGVLTRCLDLHIIEKHRQQGRPLLPEHKLAGFWIGTPILAGALWVFAWTIPPEVTNVHWTVSTLALVLIGYALNEIDYVLSGYLTDSYLSYAASGLAALSLVRALLSAALPLIAVPMFSDLGANVAVSVLAAIATVFCLVPPLFSRYGETIRARSQFAKYSLRMYNESSVDENGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQL2</accession>
    <name>A0A2I2GQL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_461097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710471.1">
        <property type="nucleotide sequence ID" value="XM_024851999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQL2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQL2"/>
    <dbReference type="GeneID" id="36559697"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461097"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="412" mass="46330" checksum="98056B73DE04A557" modified="2018-02-28" version="1">MSLSRLPLELILNIAHFLRCQRDLSSFMRTTRTFYSLVHPVLYRFDVRKRLGSALLFAASNGYTDLVKKLLAAGASIEACDRTDVYGEYEMKPDGTCTKAGNPILAAAHHGHLATLKTLLAETRPRQSCTNPQMRVVLHWAIRSHNIEIIDLMLARGAAIGLPKGEYIVFLKSNTALGVAITSGCPDEILERLLQRGAEVWEPENPCPWYEATVQREGHMLQLLLKHGRRPNSDRVLCELALRCDDTRALARITDPTTGGLDIRIHGHPALFTAVEMGHFEMAKYLVAHGANPHLHCSYQEWGGRYSTVWAAVQARHMGLLRFLVTEQGVRPDEQDIREAVRAEFEEAVTLLSSRGCQETPEKEYMTSYVTALKEKMNLKPSFHITTHAHLRCPTSKAAFLAQVRGNYPTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQU3</accession>
    <name>A0A2I2GQU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_443083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710533.1">
        <property type="nucleotide sequence ID" value="XM_024850506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQU3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQU3"/>
    <dbReference type="GeneID" id="36558205"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443083"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="176"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="467" mass="52377" checksum="B5B7CFC8E9E55528" modified="2018-02-28" version="1">MARRLSEMTEQAMLEGGRSARKNMEQAGFSEDLKKELEERIAASAFKSEHATAHSIVDMPESAGQGTRDIAGAQPWGGSENLHDVTLRMLDSSKKPLRTPYKIPQPNPVDMRISPKPKKSPGLRLAEAKERTSTYTLSQSPGVSDHEREAMRKEMRERFTPGARPMPVTIQGLTSLANERIEDAIARGQFDKIKRGKGINTETDHNANNAYIDTTEYFMNKMIQKQELVPPWIEKQQEIAREVGRFRDRLRTEWRRHAARKIASHGGSLEAQMRRAQAYAAAEARLVEKAKTEKSFQDGGGSEASSVELESNLSEISASLAEEDPNASAPETLNTPDTEDASRLPHLPPFRDPEHLAIERSFYELTIKNLNTLTRSYNLQAPPVAQKPYMNLERELSACYADVAPSLAEEIKRRATERARTPESVGSKANGLLDSLSTSPTVNVYEEDQAKGYGFKQFWRDMFSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRC2</accession>
    <name>A0A2I2GRC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid activator Faa4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_421992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710742.1">
        <property type="nucleotide sequence ID" value="XM_024847401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRC2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRC2"/>
    <dbReference type="GeneID" id="36555100"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421992"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="97"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="683" mass="74327" checksum="FECD64740DE1DEFE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSC6</accession>
    <name>A0A2I2GSC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_433265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711072.1">
        <property type="nucleotide sequence ID" value="XM_024848443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSC6"/>
    <dbReference type="GeneID" id="36556142"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433265"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="12331" checksum="6F189976654F2729" modified="2018-02-28" version="1">MPTLMSWFRGPYFLFPVIRHGFPPAETRSSDRLQQWQPAIWSVASTVYLLSALSSSTPRYSVVSLVYAVYNLGLVPACVQDPDWSPYAGTAHWPIGPVQGPTVHCFPPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSP8</accession>
    <name>A0A2I2GSP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="5 15">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_443595</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="5 15"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711205.1">
        <property type="nucleotide sequence ID" value="XM_024850565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSP8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSP8"/>
    <dbReference type="GeneID" id="36558264"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443595"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF4">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014183779" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="18">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="17">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB55903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="355" mass="38952" checksum="E02ABEDF720B5B7E" modified="2018-02-28" version="1">MALLLGLFILVTLAVRRSFLSSRPEAFAPAHGTDLRIHDPSILKVGDTYYSYGVGKYLAIHQASSLDGPWEQTGTVLGKDSVIPKGDRNAPWAPTTIEFDGTFYCYYSVSYAGCRNSAIGVATSKSPGPGDWTDHGSIVQSGKGRGSAKYPYTVSNAIDPSVLVTDDGQGYLTWGSYWTGLWQEPLSKDLLSVVSGEQSEARHLAHEPRAIFPGRRNPKNQLCGDPTGGHPVEGGFISYHAPYYYLWFSWGKCCKYNPENLPKPGMEYQIRVGRSVSPRGPFVDRTDRDLVDGGGEVVYGSNREVYAPGGQGVLTEDGTDILYYHYLNTTIGYGFWEARLGYNPLEYVDGWPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQD3</accession>
    <name>A0A2I2FQD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_371392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000024">
        <property type="protein sequence ID" value="PLB42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371392"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="74" mass="8863" checksum="433BD7466C05C8E4" modified="2018-02-28" version="1" fragment="single">ILTPPTIPINHYGGPRNQQNRTARPILLFHANADRPARPRFNYELFNCNNFNIRYWSWNYRGCWHQTCPPIVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRI0</accession>
    <name>A0A2I2FRI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_419109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698546.1">
        <property type="nucleotide sequence ID" value="XM_024847262.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FRI0"/>
    <dbReference type="GeneID" id="36554961"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419109"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="376"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="649"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1540" mass="173521" checksum="5D77EC5B564310E4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRP8</accession>
    <name>A0A2I2FRP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellobiose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_431262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698614.1">
        <property type="nucleotide sequence ID" value="XM_024848016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRP8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRP8"/>
    <dbReference type="GeneID" id="36555715"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431262"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014114252" evidence="4">
        <location>
            <begin position="20"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="809"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="809"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="896" mass="92449" checksum="E91A3013CBE79B2F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRS9</accession>
    <name>A0A2I2FRS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_481264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698619.1">
        <property type="nucleotide sequence ID" value="XM_024853850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRS9"/>
    <dbReference type="GeneID" id="36561548"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_481264"/>
    <dbReference type="OrthoDB" id="4497130at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014157366" evidence="1">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="85" mass="9094" checksum="158E9A8322B620A4" modified="2018-02-28" version="1">MHFSLSALFVAALGLTSTALAAAIPETEHTVSEYHWHGCAAGVFCTSDSDCRSEDACLTTADNIPTNIHCGQANYPHSCWAEYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS03</accession>
    <name>A0A2I2FS03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_77061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698714.1">
        <property type="nucleotide sequence ID" value="XM_024855376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS03"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS03"/>
    <dbReference type="GeneID" id="36563083"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_77061"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="641" mass="71526" checksum="49E9AD3820EBC7ED" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSP7</accession>
    <name>A0A2I2FSP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698970.1">
        <property type="nucleotide sequence ID" value="XM_024850239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSP7"/>
    <dbReference type="GeneID" id="36557938"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441125"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="125" mass="14674" checksum="1C436F5E65DA5A33" modified="2018-02-28" version="1">MITFLNLPRPIREQIYRYVLVMARIFVRPFISMDYLFDPNRVETYGSPTLSLLSVCKQIHHEATPIYLRENTFSIVHIDLLAAACRELPRIAHNLASIRHLELVFDCRDYIYFSQFVAEQLPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSX2</accession>
    <name>A0A2I2FSX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_430749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699018.1">
        <property type="nucleotide sequence ID" value="XM_024847974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSX2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSX2"/>
    <dbReference type="GeneID" id="36555673"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430749"/>
    <dbReference type="OrthoDB" id="4207724at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016365424" evidence="2">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="394" mass="42733" checksum="2BB707A4FFF0CAAB" modified="2018-02-28" version="1">MMNPYLSWALLLVVAGGLGWYYNGPTPKASVPIKPVVEKTESALGVKKPKRKAKKSPEPSAPAAKAEEKPAYVPQTEEADQQDEEIDQKEMAKRFAAVRDGTIAQTGKSQKKKNNKKTTTLSQPENGNERSASRVSTRTSSTTGADADDDLSSAESPQVNAATPTTGYVSDMLEAPAPGASVLRVTGSMEEQKKKQKPQSFKQVETKKQRQQRLKNEARKQQVQEAEQERRKLLEKQLHSAREAERQQAAQAKPAAPQTNAWQTKPVSNGTPKVAPKVAPAAAPKVDLLDTFEPEAKSSKPTGEWDQGLPSEEEQMRILEAGDDQWTTVSSKKIKKKGGKADESEASAPETTPAPAAASTPTPVEPKVKVTPTYLPDVLLSKQKGHPLDSDWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTV0</accession>
    <name>A0A2I2FTV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_431053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699372.1">
        <property type="nucleotide sequence ID" value="XM_024848001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTV0"/>
    <dbReference type="GeneID" id="36555700"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431053"/>
    <dbReference type="OrthoDB" id="5302289at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="100" mass="11432" checksum="48DF563E818EF0D5" modified="2018-02-28" version="1">MANSTSSANQARIRQALEHARNCEDGNIDRQTSEILEAAITDLWRRIQSQPDSYVLSRDEFALFNYFLRRFNGSPVARRAVERFWNNYQGTGSSVDGSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUZ7</accession>
    <name>A0A2I2FUZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_468115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699733.1">
        <property type="nucleotide sequence ID" value="XM_024852530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUZ7"/>
    <dbReference type="GeneID" id="36560228"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468115"/>
    <dbReference type="OrthoDB" id="4336378at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="381" mass="42362" checksum="163D73E493CD9872" modified="2018-02-28" version="1">MGWFTSIVQGVGSAVNWAMSNAGDIAGLLASVGKVSALHAPEGRAEGQSPITSKDYFKAFRDAGKVLEARAIKKVKDIEEDKDWGDPRMPKDDPQEPIITTGDISGIWTSPTLFSNTSKEVPEMYRDLVKLLAELGVPTLMKQHGRDRDVAEVVAQGIFASNPQPPSQITNFDANNDHHLPTYGVALRHDDKSWQVFVAHSYYTIPMGRTGTDTAWHGAIHVKFKARPDAISLHAQEMEEFRFIQDIEPLAVDVWLVTFQIAWKAVKVARTGYKFIKKVLDERKDNPSNPGYEVTYNFLDGQLQTVKIKAPANKAPSETLFYLQEAVADAVVQMNQSPQEMYFANDENKATQYQTPYVALTDSTILTSDTDGVDRLVVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVJ8</accession>
    <name>A0A2I2FVJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_440908</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699962.1">
        <property type="nucleotide sequence ID" value="XM_024850183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVJ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVJ8"/>
    <dbReference type="GeneID" id="36557882"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440908"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000029">
        <property type="entry name" value="Mitochondrial enoyl reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="73"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB44660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="423" mass="45853" checksum="890E3DB867BC9E3C" modified="2018-02-28" version="1">MFSRTAVRSTVTTSRSNAILSLKARAASPLVSTAAGPCCGPLPNAFMGGKRFIAVYGYTQAKALVYSRYGEPKDVLQLHKHSISPPHGSQVTLRLLAAPLNPADVNQIQGVYPSKPPFQSTLGTSEPSAVAGNEGAFEVIATGANVKNLSKGDWVVMKQTGQGTWRTHAQMDESQLIRIANKDGLSPLQISTVSVNPVTAYRMIKDFCNWDWMRTGEEWLIQNGANSGVGRAAIQLAREWGIKTLNVVRERETPEKTEALRQELRELGATAVVTEAELLSGGFKNQVNELTRNGKEPIRLALNCVGGKSATALAKTLAPGSHLVTYGAMSKQPVSLPSGLLIFKNLAFDGFWVSKWGDKNPQLKENTINDVLQLTRSGRFKDIPVDEIRWSWETEGSALTAGVQETLSGYRDGKGLLKFEGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVN0</accession>
    <name>A0A2I2FVN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_439949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700001.1">
        <property type="nucleotide sequence ID" value="XM_024849954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVN0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVN0"/>
    <dbReference type="GeneID" id="36557653"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439949"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="31623" checksum="98CFE33F5F8C2DE6" modified="2018-02-28" version="1">MDEYVGLPRDHPESYHSFMYKHFFSHVDIAPQNINILDGNAPDLAAECASFEARIARYGGIELFLGGVGPDGHIAFNEPGSSLSSRTRVKTLAYDTILANSRFFGNDIDKVPRMALTVGIQTIMEAREVVIVATGAHKALAVEKGLEGGVNHMWTLSALQLHQHPLIVCDRDATLELKVKTVRYFESIENSGTDARTQGPPLVYRPRTYVPAPIGVVKSHQQPTPLCTPTKVPKDLRINTELSQTIEDDELTPDSMSSRMVDSAISGLDSTLKDELMFDRMGTRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVU9</accession>
    <name>A0A2I2FVU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700075.1">
        <property type="nucleotide sequence ID" value="XM_024849972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVU9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVU9"/>
    <dbReference type="GeneID" id="36557671"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440019"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="22620" checksum="FE6F4ABF9FE6E278" modified="2018-02-28" version="1">MSGILHKVKEAVTHHGHHHETPNKSHAEPTNQTYNQTPTTTHTDGYGANTTTSGPYLHGDEKPTYNAPMGDDGISPRTSTVNTSQPQNTGDKPSNVANKADPRGDNDKANAKAKDDISRFYDEVRQGSIGGAGVIHASGSNGPTTTKTFDPQASLGKGGGAQVHSSSAAGSSYNTNAPGSGSASQTTGPHGSDVANKVDPRVDSDLDGSRTVGAQRDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVW6</accession>
    <name>A0A2I2FVW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb1 C-terminal repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_391040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700028.1">
        <property type="nucleotide sequence ID" value="XM_024845928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVW6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVW6"/>
    <dbReference type="GeneID" id="36553627"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_391040"/>
    <dbReference type="OrthoDB" id="6365728at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038799">
        <property type="entry name" value="LEKR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251:SF1">
        <property type="entry name" value="LEUCINE, GLUTAMATE AND LYSINE RICH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251">
        <property type="entry name" value="LEUCINE-, GLUTAMATE- AND LYSINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128643" checksum="D01FBFDC84CD6475" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWB9</accession>
    <name>A0A2I2FWB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_440115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700209.1">
        <property type="nucleotide sequence ID" value="XM_024849996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWB9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWB9"/>
    <dbReference type="GeneID" id="36557695"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440115"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="172"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="743" mass="85330" checksum="4B0D7983305680C3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWR0</accession>
    <name>A0A2I2FWR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_458639</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700381.1">
        <property type="nucleotide sequence ID" value="XM_024851813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWR0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWR0"/>
    <dbReference type="GeneID" id="36559511"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458639"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB45079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="363" mass="40704" checksum="A874A83586D211D5" modified="2018-02-28" version="1">MQVKFEPLKNDLLLRAARGEKVERPPIWVMRQAGRYLPEYHEAKGNRDFFECCRSPEIASTLTIQPVERYAGLIDAAIIFSDILVIPQAMGMLVEMVDKKGPHFPEPLKSPDDGQYEKVMQKQVDVKSELDYVYKAITLTRHKLQGRVPLIGFCGAPWTLLCYMVEGGGSKLFVQSKTWVYKYPKESQALLQKIAEICVEYLALQVAAGAQLVQVFDSWAGELSPSSFQSFSLPYLRHISANLPKKLTEMGLEPVPMTVFAKGAWYALEDLCDSGYNVVGLDWLHDSAEAMRVANGRVTIQGNADPGMLYGGPEAITPVVEKMVEGFRKGKQGWIANLGHGVTPFVKPENLKFFFEEIHRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWR1</accession>
    <name>A0A2I2FWR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_513121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700349.1">
        <property type="nucleotide sequence ID" value="XM_024855067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWR1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWR1"/>
    <dbReference type="GeneID" id="36562773"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513121"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF17">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="303" mass="34400" checksum="A9060CD13E10789A" modified="2018-02-28" version="1">MDFEFHPGQNGSDPWVEFYPYNPSKPAGYAFVVIFGIATIAHLVLMFPYRAAYFIPMLLGGVCETFSYYGRAWSHNNRTLISSWALQQMLIMCAPPLVAATIYMILGRIIRACNAEHHSSIRTKWLTFIFVTNDVLCFLTQIFGAGVQVTGDAHIMSIGVKVVLVGLVFALVVFAVFVWVAFQFHRRLKRDPTPVAYQNGGLHWERYMWAIYISCLALMIRNLVRTIEFGASGSDLGKKEIYIYIFDAVMMFISMAVLIVWHPGLLIKRLRNMNKANEMYGPLEGETQSADVPLTGYMAQERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY76</accession>
    <name>A0A2I2FY76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_478528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700874.1">
        <property type="nucleotide sequence ID" value="XM_024853569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY76"/>
    <dbReference type="GeneID" id="36561267"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478528"/>
    <dbReference type="OrthoDB" id="4519339at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="134" mass="14815" checksum="AF63BA315BD7EF33" modified="2018-02-28" version="1">MAQDDSNPGIFNELPDQAKATVERIKRIIGEDTTKKEGKASSGWGFSSEELEQEIQRLSAELSINGYKAYNCKVLHLVHGGIIQNGTGHQIIIPLNGKASFLHDKPLLPCHYTTQKETLLGDNIDLIIMSLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY98</accession>
    <name>A0A2I2FY98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_449268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 23096</strain>
        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    <sequence length="858" mass="94066" checksum="49179592B0C97A3E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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                <person name="Theobald S."/>
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                <person name="Lyhne E.K."/>
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                <person name="Kuo A."/>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYF1</accession>
    <name>A0A2I2FYF1_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
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                <person name="Nolan M."/>
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                <person name="Henrissat B."/>
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                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701175.1">
        <property type="nucleotide sequence ID" value="XM_024851045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ01"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ01"/>
    <dbReference type="GeneID" id="36558744"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449463"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="348" mass="39989" checksum="CB3066F53DB91BE2" modified="2018-02-28" version="1">MATLMRRATRVLRRTPSPPMSFPTSGFEIVRSSEVLDEERFDHFKQGQYYPANTGDVLSSKYQIFGKVGFGTTSTVWLAHDLEGHQYVTLKVYTRDEGRGSSWHPGHAHIRKALDLFTIPRAVHLLKAGLMQIFLALDYLHTECKLVHTDIKSDNILQEIEDMPILESFTQAELKKPSPRKIVNVLSDFGSAVRGDERRNHDAQPNVYRSPEVMLKTDWSYPVDIWNVGVMVWDLFEGRHLFHGNDPDGKGYSTRAHLAEAMSLLGPPPLDMLQRGKRSHEFYTDDGKWKQDIEIPTGVSLESSEQFLEGRNKEMFMAFMRGMLQWRPEDRKTAKDLLQDPWLNGQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ05</accession>
    <name>A0A2I2FZ05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysR family regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_478805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701174.1">
        <property type="nucleotide sequence ID" value="XM_024853593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ05"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ05"/>
    <dbReference type="GeneID" id="36561291"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478805"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56272" checksum="282902C3F2304174" modified="2018-02-28" version="1">MKPPKPVLTDTVIPLHLRDNALIYRNFIADVTFIFDDVLDADLVRNSLEDLIAFGEWRKLGARLRLRDDNGLEYHIPQRFDAKRPGVTFNISDYNMRMHEHPIASKVPRASNKLQLFSSPDEFDGLLRQPNTPCRLEDWIYSDRPQLEVYMIRFEDATLIRMTSLHTLMDAVGRSGLLQAWTAKLRGRDDQIPAFHGFSEDPMASYTTDALPRRPGNSQNGNPFLGWLREPIRLATALFSSFWAPVLETRFLCVPGHYLDSMRELARKQLEGGTNDEDKEPQFVSEGDVLLAWWIRTWVSAINPPPSKTITIVNMFNFRPALPELFPKGAMFLGNTIMTIGTRVPVGEMLQKPLGYLARRIRESIMSQSTRDHVELQAAIQARGIQDMGVREPFQEPDPLVLACTNRHKARYFDVDFSAAVSKEGAPKAHRSSAPGKPFFVLSRNFWLGSNRPSNSVNIAGKGPDDCWWISQTLPRNAWGGIERQLADANCNESIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ38</accession>
    <name>A0A2I2FZ38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_364881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701201.1">
        <property type="nucleotide sequence ID" value="XM_024844669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ38"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ38"/>
    <dbReference type="GeneID" id="36552369"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364881"/>
    <dbReference type="OrthoDB" id="5424234at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="438" mass="47048" checksum="21A158D6ED05E898" modified="2018-02-28" version="1">MDELPKGLVSSTGQVPSTLEDETAVDVGDIVQLWKAYSANASVHEGDMGHRLENFFWRIWSSEDLCRSIDGSRLAKLFLRISEASPLSLATPQPTTTKAPQARSHTNIAPNDDKSPSSNGSSRTPMPPPILKKSNTSHGETQKTTRLLLTGVGGQSITRKPSTPPTPVPPPSRKAYFVAGKAKSNKRRPVLMRRKSSQTSSGASTRTHSPQRIPTPLTSTSPVQISEQDSGSTTEMEEPSVEEPPEPGKEAKETTAGTNELPASFLTSLKGILGDKWVPSQGTKSTPPKWGYVTRDDFTHYDVNFLSAENYAPQPSSSSLVDKDFRTRFAERKRQEYEELVPSLGEAADADATNAAPQATTNWVSPTSASSGIPIMTPATGSMSSAGRMTGDATPSPQTSMSAPKGRSQLSVLIEESRNKQADTQVVSIPEDALNSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0K1</accession>
    <name>A0A2I2G0K1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_214706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701668.1">
        <property type="nucleotide sequence ID" value="XM_024842827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0K1"/>
    <dbReference type="GeneID" id="36550526"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_214706"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="130" mass="14178" checksum="C8CA29C927B6DC3B" modified="2018-02-28" version="1">MPLYWTRLASASRPFMTPSALSTLGAKNISTLVYSSNLLLGGAPAKRALAHSSALLRMARDALARCPSVLRVLRGSFGQSLLVFARLLTRSNYVWPGKRRCLPVGLGSASVKDQLWNFEFDAARLSKVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1G7</accession>
    <name>A0A2I2G1G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_438420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the bZIP family. GCN4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702023.1">
        <property type="nucleotide sequence ID" value="XM_024849599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1G7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1G7"/>
    <dbReference type="GeneID" id="36557298"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438420"/>
    <dbReference type="OrthoDB" id="5419235at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001491">
        <property type="entry name" value="Cross-pathway control protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="217" mass="23591" checksum="2846F0723E0066DD" modified="2018-02-28" version="1">MLSPQQIPTGIMAPKEPMGDAPTGTISPKDLLMDASAPPSTSFTDLSTPSFESPGYFSQDTSPMFATDMELAPGHEEWDSLFPTQDSFPSLPFDSVTLDAATAVLSKPQEEVPMPSPKARSPSIAPSPSSRSATKPSSVAGVNPRSRKALAPIKFDSADPVAMKRARNTEAARKSRARKLERQDDMERRIAQLEKSLEEAEQREQYWKALAQAQNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Y0</accession>
    <name>A0A2I2G2Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_438930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702531.1">
        <property type="nucleotide sequence ID" value="XM_024849719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Y0"/>
    <dbReference type="GeneID" id="36557418"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438930"/>
    <dbReference type="OrthoDB" id="5391496at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="224" mass="24860" checksum="4860A492FB620447" modified="2018-02-28" version="1">MGAVRVPQIYLENHVSSFLQYILDNNASTILLIICSKRDEFLRRLLATVYTQSNESANSRQLVTKTLGLLSKSSRTQVAFCPTLEHLRAYLSVLQFNNAAEQETNAPEDQQLCRPLMAILDPLALHLSTSEFAAQGLSRTLAAAVETSSREAVDLVICECQDVARPEDSGEALWNAHVPLLNSSVRTGRDESTWGGQSVPVKRIAQRWFVFSDPRISTTNNPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Y7</accession>
    <name>A0A2I2G2Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_428444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702540.1">
        <property type="nucleotide sequence ID" value="XM_024847843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Y7"/>
    <dbReference type="GeneID" id="36555542"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428444"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="114" mass="12967" checksum="5E87717D42D97C47" modified="2018-02-28" version="1">MKHGDHGHALNMKTNGSPKAMSTGTENRNVMILARRYRCLQPVTLSAKKSRPDEAVWSQGAPRLFLNAIVDILQWLGSLDYRTLPRTMHVDLVLSGMCYQFLYLTIFICVYEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3I9</accession>
    <name>A0A2I2G3I9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_439097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702741.1">
        <property type="nucleotide sequence ID" value="XM_024849760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3I9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3I9"/>
    <dbReference type="GeneID" id="36557459"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439097"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="218" mass="24589" checksum="57D683C8E8AF9F7C" modified="2018-02-28" version="1">MANPALWALFFLIQVPLVVMIIWATRLWRRHRRSGLEEFYPQFRRPDIEAVRPKKVRPVMSSEDVDRRFPTVGYSAWKSAHETPSQASAPRASAQLERTTSRDNDEPEPPNKQTTINDAHQNEPPSPDSDSYSVCAICVDQFDANDEVRPLSCGHIFHPACIDMWLTKRQACCPLCKTVYAGLRVSSESNRDGEAEASTMPEPPAAAVVRGERIPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3N9</accession>
    <name>A0A2I2G3N9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">FRE family ferric-chelate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_409563</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702791.1">
        <property type="nucleotide sequence ID" value="XM_024846790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3N9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3N9"/>
    <dbReference type="GeneID" id="36554489"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409563"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014199130" evidence="11">
        <location>
            <begin position="20"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="434"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB47489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="766" mass="86772" checksum="7BE7C131EBBF675D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G409</accession>
    <name>A0A2I2G409_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydroquinate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_409788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702901.1">
        <property type="nucleotide sequence ID" value="XM_024846811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G409"/>
    <dbReference type="STRING" id="1392250.A0A2I2G409"/>
    <dbReference type="GeneID" id="36554510"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409788"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="192"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="391" mass="41968" checksum="186C2BE1BBCC0724" modified="2018-02-28" version="1">MANTQIPQGHWQPGPLPKDIYYGSGCVARHLLFCLAPSSRVFVITNTSLSKTPLLPQLESILGAQHAGTISSIKQHVSLSDIEDALSTILSTTHTPTPITLLSLGGGSAIDATKIISYKYHSATRSFLPHIAIPTTLSGAECTPGGSYTITEQSPTTPVTTKKAIIHPDLAISTIFYDPIYAAHTPPTLWLSTGIRALDHATECMYHPLAAEVPWKALALFAFSELLTCLPLSKAHPTDDNLTVRLMLAAYASSGFKGSNIGGELGLSHRLGHVLGSAYGIPHGITSCMTLGRVVCVKARDRDAAAQIVRLIPGIEAGDGDGRLRTGDDYADAVQVGKRIQGLARELGLEGKLGDYGVERDEVERIVRRVVGDEGDEREMKEVEEVVMRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G465</accession>
    <name>A0A2I2G465_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_426907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702976.1">
        <property type="nucleotide sequence ID" value="XM_024847742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G465"/>
    <dbReference type="STRING" id="1392250.A0A2I2G465"/>
    <dbReference type="GeneID" id="36555441"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426907"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="518" mass="57028" checksum="63770D9C858F6D2F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4Q7</accession>
    <name>A0A2I2G4Q7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_465384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703135.1">
        <property type="nucleotide sequence ID" value="XM_024852318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4Q7"/>
    <dbReference type="GeneID" id="36560016"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465384"/>
    <dbReference type="OrthoDB" id="2942798at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="129" mass="14828" checksum="AD3D5BFC832DA564" modified="2018-02-28" version="1">MGFKTNSQLPLSFRLGSRLVFAKSATWIDARKPNVCHLELIQPFFLTLMQYTIGFLCPWIKARWPEWFLPEAVILKRPKPDWESEYATEKKAYELLRPIQGVITPYFYGEAVYDGSPALVLSAVTGQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G521</accession>
    <name>A0A2I2G521_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_386054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703278.1">
        <property type="nucleotide sequence ID" value="XM_024845755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G521"/>
    <dbReference type="STRING" id="1392250.A0A2I2G521"/>
    <dbReference type="GeneID" id="36553454"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386054"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="214" mass="24667" checksum="8442636B8A674FDD" modified="2018-02-28" version="1">MHRQSIARLARQCNGLPLADLPPAYLAPSLHFSLTRSAVQTSNFSTTAVAAGPGRDLNKTRGVSAIHRTGPRFKLGVSKYPLPKPVSPGELDKRHPTPDHGLWGFFPKDRQPLSTPEYDNAHGRSWSIQELREKSWDDLHALWWVCAKERNRIATSNLERERLKAGYGEYEANDRDRVIRVTQKSIKHVLRERWYAWEEAQRLYKEGYRPQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5Q3</accession>
    <name>A0A2I2G5Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_427314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703507.1">
        <property type="nucleotide sequence ID" value="XM_024847767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5Q3"/>
    <dbReference type="GeneID" id="36555466"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427314"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="235" mass="26785" checksum="82CA28C8B115BDBB" modified="2018-02-28" version="1">MTEHRLNDLLTPLFLNEYISNELRSIFIDFVFHGRPRRDIDGANGMNSCNRLLQIPVDSRKFHGLWGDAIAAAQNGNTYLSTRWEVGCFRRSENGKLESAPFASDDLFHARYLRRCPADCASLPNCEGLLIQRESMNTQFLGGCKLRESRIAISVSSMMGSKPASFSTVTLRDHKSEEHHDMRSPRAREDARILMRANNCGGFPCVAEFQVETHVLLQDWQQEWNSTLGHIERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6I6</accession>
    <name>A0A2I2G6I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_511063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703796.1">
        <property type="nucleotide sequence ID" value="XM_024854848.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G6I6"/>
    <dbReference type="GeneID" id="36562554"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511063"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="813"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1892"/>
            <end position="1968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2407" mass="264929" checksum="CC18DC3AECCC7F9D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7A7</accession>
    <name>A0A2I2G7A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_407447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704068.1">
        <property type="nucleotide sequence ID" value="XM_024846683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7A7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7A7"/>
    <dbReference type="GeneID" id="36554382"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407447"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="340"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111097" checksum="45CDCA6F0439B8BA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8D0</accession>
    <name>A0A2I2G8D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_475441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704427.1">
        <property type="nucleotide sequence ID" value="XM_024853260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8D0"/>
    <dbReference type="GeneID" id="36560958"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475441"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28856" checksum="50CB4FF7805E4172" modified="2018-02-28" version="1">MFLPSVHAETDRDVLLQFIRENPLGMLITGINSSQHSYLQCTHVPFVLDAHDDSNASEPRLRAHIAKKNPQAQALIEGVDNKPPSILDLDDEVLVVFNGKHDHYVTPKFYTETKPATGKVVPTWNYTAVQVYGKLSLYYDSKSPDAGAFLAKQIHDLSEHAERSIVGHTGDGNGARLKPWKVSDAPGPYLALMKRNIVGIEIKVTKIEGKFKMSQEMRPGDRQGVVDGFGKIGGDTGDFISDLVKERGEIHDQKKGERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8N5</accession>
    <name>A0A2I2G8N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_177738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704520.1">
        <property type="nucleotide sequence ID" value="XM_024842647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8N5"/>
    <dbReference type="GeneID" id="36550345"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_177738"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="72" mass="8040" checksum="5BF2EE5B21A83106" modified="2018-02-28" version="1">MSQGLTRVGQRKIPVYRLCLTLGPWDRAVLVFFGLVYQLPPPSRKPSTCLPSLSFSPSIALYIDPAHITVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G993</accession>
    <name>A0A2I2G993_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_437025</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704756.1">
        <property type="nucleotide sequence ID" value="XM_024849271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G993"/>
    <dbReference type="STRING" id="1392250.A0A2I2G993"/>
    <dbReference type="GeneID" id="36556970"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437025"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014135130" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB49454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="313" mass="34091" checksum="DA86C334A7444E4A" modified="2018-02-28" version="1">MHLPAHLQLLLALLPAVVLSYDGASQRPPGNKAILLSQVQTLTLRGDRLTSSRRVSPIPQLQCVGPSKRICDSYPIEIMRCTNAGHDYDEEDVQWTCTASLPPELKLGSTDVICEGYRNADDPWVLKGSCGVEYRLLLTDLGEKKFGRKHDDNWSEGIARHKWQKALSVIGSVLFYGFVAWVLIVMLDACFGAQGDRRRRTPGRGWGGFGGDGGGGGGGGGGGPFYDPPPPYSSHSDSSRGWRPGFWTGALGGGAAGYEYGRRSAYNSSRRHSPPSRRRNESYDPGEGSSRSPSYRFSDTTTTSTGFGSTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9H4</accession>
    <name>A0A2I2G9H4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_475816</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704826.1">
        <property type="nucleotide sequence ID" value="XM_024853290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9H4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9H4"/>
    <dbReference type="GeneID" id="36560988"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475816"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="394" mass="45138" checksum="8C320D55B252C672" modified="2018-02-28" version="1">MSQNRPGMFSSLRMGEVVREKVQDGLTGETKEISYSQCKIVGNGSFGVVFQTKMMPGGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGERKDEVYLNLVLEYVPETVYRASRYFNKLKTTMPMLEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPNSGILKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRRAPHEAIDLISALLEYTPTQRLSAIEAMCHPFFDELRDPNTKLPDSRHPNSSSRELPSLFDFSKHELSIAPAMNSRLVPPHARPALEARGLDIDNFTPLTKDEMIARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9S4</accession>
    <name>A0A2I2G9S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_190219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704933.1">
        <property type="nucleotide sequence ID" value="XM_024842700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9S4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9S4"/>
    <dbReference type="GeneID" id="36550398"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_190219"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="420" mass="46733" checksum="7F5C2F952EC8471E" modified="2018-02-28" version="1">MQKLQRIQQNPNSVGAELQDPRFLQVMSVLLGIDMSFGAPPEAAGAAGGPSGATEAEDEEMPDIRPSQPKKAPEPAPEPEPEPEDEEAIAKKKAQEAGDAEKKIGNDFYKKKQFDEAIEHYNKAWELHKDVTYLNNLGAAKFEKGDLQGTIETCQKAVEEGRELRADFKVLAKSFARIGTAYDKMGDLTQAIEYYNKSLTEHRTPDALSKLRVAEKAKATAEKESYIDSGEAEKARELGQKKFQEGDWPGAVDAFTEMTKRAPQDPRGFSNRAAALVKLMAFPQAVQDCDEAISRDSKFIRAYMRKASALMAMKEYNKALDVCTEASEHDDGSFAREIEQQQQKCLDSQFSARAGETEQQTMERIQNDPDIMAILQDPVMQSILQQAKSDPAALQEHMKNPQVRMKIQKLMAAGVIRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA95</accession>
    <name>A0A2I2GA95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aromatic prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_358697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705102.1">
        <property type="nucleotide sequence ID" value="XM_024844310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA95"/>
    <dbReference type="GeneID" id="36552010"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358697"/>
    <dbReference type="OrthoDB" id="3913316at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020965">
        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036239">
        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11468">
        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01163">
        <property type="entry name" value="II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="Prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="315" mass="35314" checksum="057B6F78612E2CF6" modified="2018-02-28" version="1">MPHYTESVFRPETATEFSSSRFLSDLESLAKEVNSSIDKPAVENVLTKFDKYFQEGCVVFRSKDRPNDTLNYRLFLFNAHDTMKAAIEAGLLDPSHPFIPLMGLWHFLCHQDQTPAFWPDFSATKATIAKTWLLISPLCSIKTLLRAPGIPNGMQDQFDTLQSAGLDKVRFIAADYDAMTVNFYWPLAEPLSRKQADQLAALGGSPPPSEDKLQEMKKYLDPRGTLFAVTMKYPTGEMTRVGFYALNVHLTPTLKDFPQVNERGTKFLTSVKSHDKVPTTVVSWSFGRDGGEYTKLEAGNSGEFEDLILHVGAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBD0</accession>
    <name>A0A2I2GBD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_138451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705494.1">
        <property type="nucleotide sequence ID" value="XM_024842450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBD0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBD0"/>
    <dbReference type="GeneID" id="36550147"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_138451"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="30076" checksum="92DAB6FF65D93A27" modified="2018-02-28" version="1">MLASTQLDGVALVVGSGRGIGQQAALSLAEAGARVVVFADINEETAKESAEQSKQYVSNKDYQATFFKVNVIDEKRVQEMVDFVVQEFGRLDYCVNGAGIDNGVQTPVADTDIENFDRIMNINAKGMMLCVRAQTAAMRKQTPKTFQGRNGTRDIGRGAIVNIASAHSFVGLPGKMSYTMSKHAVMALTKMAGMDHAAEGVRYNAVCPSWVRTPMLDIEIEKNPEVRDTIKAIVPIQRVAEGEEVSDTIAYLLSPAASYITGTSIVIDSGITTTVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC60</accession>
    <name>A0A2I2GC60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_435652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705764.1">
        <property type="nucleotide sequence ID" value="XM_024848989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC60"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC60"/>
    <dbReference type="GeneID" id="36556688"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435652"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="59" mass="6445" checksum="C7CD91824B7787EC" modified="2018-02-28" version="1">MASTTNVPFIPDYASYNWTGAPSNYEQLATNELGGNSRMLICTQGAYVCNPMETNCGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCU1</accession>
    <name>A0A2I2GCU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_355342</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706006.1">
        <property type="nucleotide sequence ID" value="XM_024844086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCU1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCU1"/>
    <dbReference type="GeneID" id="36551786"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355342"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="18">
        <location>
            <begin position="72"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB50704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="440" mass="46785" checksum="43F926443C2E0B2B" modified="2018-02-28" version="1">MSDHSRAYIGTAFVAGALLTLGVKDLLYPKLEQHLRNSRRESQSTITLQDLTKEDDIPISRSGPPAIVDGIEGCIGNTPLFRIKSLSEASGCEILGKAEFLNGAGQSSKDRVALSMIQIAEEHGILTPHSGDTVYEGTSGSTGISLATLARAKGYLAHICMPSDQAVEKSDLLLKLGAIVDRVPPAPIVEKDNFVNRARALAHAHTASSANVSDSESSIPGSAEVSSPTPGRGYFADQFENEANWRAHFNGTGPEIYAQCGGKLDAFVAGAGTGGTISGVALFLKPKIPNLSVVLADPQGSGLYNRVRYGVMFDIKEREGTRRRRQVDTIVEGIGINRVTANFEVGKELVDDAVRVTDAQALAMARWLVEKDGLFLGSSSAVNCFAAVKTAMRLGPGHRIVTVLSDSGSRHLSRFWAKAGNVGGAVDTKLEDVLNAKDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCZ1</accession>
    <name>A0A2I2GCZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_153443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706056.1">
        <property type="nucleotide sequence ID" value="XM_024842532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCZ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCZ1"/>
    <dbReference type="GeneID" id="36550229"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_153443"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="472" mass="53511" checksum="123B0577D8339142" modified="2018-02-28" version="1">MVDKEPGSPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRSNASHFLLSTNDKTIKLWKVFDKSLKVVAENNLSSELTPAGVGGGGAPRAPRQSFKDPSLLKLPRMTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRVNLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPTSCNWFMYASSKGTIKLADMRQRALCDEHHKLFEQEEDASSRSFFSEIISSISDVRFSNDGRYIVSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAENVMTGSYNNNFMIYPTEQQKETEIVLQADKSAFKAKKVGVPTPMNKNANGKKNGSRAGSPAGPGSRMKKETDADQIDFNKKILHMSWHPYEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD00</accession>
    <name>A0A2I2GD00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_152987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706047.1">
        <property type="nucleotide sequence ID" value="XM_024842531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD00"/>
    <dbReference type="GeneID" id="36550228"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_152987"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="52" mass="5928" checksum="DF83C00563849B8A" modified="2018-02-28" version="1">MRDKRPLLSLGMVLWITMPFVPPALRSGSLSNLRAKESRQKEVLKISSTMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD12</accession>
    <name>A0A2I2GD12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_474318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706065.1">
        <property type="nucleotide sequence ID" value="XM_024853121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD12"/>
    <dbReference type="GeneID" id="36560819"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474318"/>
    <dbReference type="OrthoDB" id="4907280at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014132405" description="Phospholipase D" evidence="2">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="35677" checksum="86160AB95DDE1E6B" modified="2018-02-28" version="1">MKLRTLTNILPLVLLALSNTTSSQVTSTSTATTLTTSSTSSTSTTTFSSTSTSTPRPIYAIAHRILTTPSLHAALTHGANVLEIDLTAHTYEWYTDHDNTLCSARATARSLFTAIADARSAGANISFVWLDIKNPDDCVLGRGCSIQALRDLAREILGEVGIGVLYGFYEQEGSTGFEVIGRGLRGREAVVLSGEVGEVEGWFDHIDVDTDVDAGNRNGSGVAAAQRVMDYGAVDLTSESFGSCNGTDGGVCSVLKTGAQARDDGQIGAVMAWTTTRGQGDMVQKMLGEAGVDGIIYGLGGAEYADDETTRAAYEDIETYVRSNGDLRMATAEDLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD36</accession>
    <name>A0A2I2GD36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_508911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706082.1">
        <property type="nucleotide sequence ID" value="XM_024854617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD36"/>
    <dbReference type="GeneID" id="36562323"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508911"/>
    <dbReference type="OrthoDB" id="4402936at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="87" mass="10092" checksum="B1C18181B48A5203" modified="2018-02-28" version="1">MKNLTFDVRYDNELAHEYYGDGQKLTDRMRQIYNGKELTFPDQYDSTFTTPPIHFMQVEAEDDVDVDGLKSVNVPPGLSIKIIDFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDC8</accession>
    <name>A0A2I2GDC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_463913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706129.1">
        <property type="nucleotide sequence ID" value="XM_024852201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDC8"/>
    <dbReference type="GeneID" id="36559899"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463913"/>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014136563" evidence="2">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="229" mass="23647" checksum="43E5AFEE54E94DA6" modified="2018-02-28" version="1">MLSKLVLLTPLLAGHGLAAHYGSHLVGMDIFKRQSEAFVPGTTPGCPDDWPMCGTSGICYNPKQGQTCCPGGKYACPSNSFCLQDPYCCPDGLDPETCAQRYGITLSPSSTEEPVPEPTKTTEPVEPTETVEPTVSKPTDPEPTETAPQPTDTVVPEPTESVPPTTTSNPVIPKPPTSTVPSVPSSTAHPTIPTASPSNPLFTGGANAREVVGGAAIVLGGLGLLGNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDJ6</accession>
    <name>A0A2I2GDJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_464003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706278.1">
        <property type="nucleotide sequence ID" value="XM_024852211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDJ6"/>
    <dbReference type="GeneID" id="36559909"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464003"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000081">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="272" mass="30511" checksum="11B66396BC78FACC" modified="2018-02-28" version="1">MTSALFTIPIASGGSIVCSNPTSSEQEKNIYLLTFTSPKDNRLTPAFIEALLLALDVVDHRYPKGVLITTSGIAKFYSNGLDLELAQSTEGFMENHLWKLFRRFLTYPMPTICLLNGHAFAAGCMLAMYHDYRIQNPSKGFLCINELEFGVPLQSPMMSIFREKLTPPAFRDLVLEAKRFTGAGSVNAGLVDALGGLDETLAFVRERGLQKKAATGIYGTLKEEMYRHSLDIVDGHEKNLEWREQVEERNERVEKEGLRAVEAWDKQRGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDL3</accession>
    <name>A0A2I2GDL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_474538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706291.1">
        <property type="nucleotide sequence ID" value="XM_024853157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDL3"/>
    <dbReference type="GeneID" id="36560855"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474538"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="121" mass="13896" checksum="81AF8C658E433CB6" modified="2018-02-28" version="1">MYLHLATRNMYNVAFSALQRCLDMITTSSQGHVAPDEQDERLEASSRAHFQLVSVIQLCSYIFNRQNQAVETLSRNHSRVSRILMLREQDSRQSVSFDAIAGLKTEVEQQLKQLHQSLCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDQ7</accession>
    <name>A0A2I2GDQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_474548</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706302.1">
        <property type="nucleotide sequence ID" value="XM_024853158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDQ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDQ7"/>
    <dbReference type="GeneID" id="36560856"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474548"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000345">
        <property type="entry name" value="Mechanosensitive ion channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="728"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="833"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="900"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB51000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="938" mass="105281" checksum="B75F49B862A428ED" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE13</accession>
    <name>A0A2I2GE13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_382297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706402.1">
        <property type="nucleotide sequence ID" value="XM_024845597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE13"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE13"/>
    <dbReference type="GeneID" id="36553296"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_382297"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014153187" evidence="2">
        <location>
            <begin position="29"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="864" mass="93272" checksum="035E92764D6CCBFC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEC4</accession>
    <name>A0A2I2GEC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706551.1">
        <property type="nucleotide sequence ID" value="XM_024847637.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GEC4"/>
    <dbReference type="GeneID" id="36555336"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425499"/>
    <dbReference type="OrthoDB" id="5350410at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1330" mass="142341" checksum="C09DD4C99F01945E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GED9</accession>
    <name>A0A2I2GED9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_493481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706524.1">
        <property type="nucleotide sequence ID" value="XM_024854047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GED9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GED9"/>
    <dbReference type="GeneID" id="36561752"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_493481"/>
    <dbReference type="OrthoDB" id="3527137at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="18334" checksum="86065D2B3ADE7AAE" modified="2018-02-28" version="1">MTSILSPQAAQADSTRITHARVVAHTVDKSKPKARENHWSIYLLHQDGKSSTRINIRAENGKQTGLLEWTQHDYTKATSAVIYLEYEALEGVTVSSVAHVIYRLGRDTHMMAEGGSRAWVYYIIDDLAQNSCISPSSPYHLWPNLSFLYLRDESDTDHRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEF9</accession>
    <name>A0A2I2GEF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_407000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706544.1">
        <property type="nucleotide sequence ID" value="XM_024846661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEF9"/>
    <dbReference type="GeneID" id="36554360"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407000"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB51242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="502" mass="57217" checksum="E7B8D575599B110A" modified="2018-02-28" version="1">MAELYPSLAQCAIVATAFKILLFPAYKSTDFEVHRNWLAITNSLPVKDWYYEKTSEWTLDYPPFFAIFEWVLSQAARYADPAMLVVGNLNYDSWQTVYFQRATVILTELVLVYALSRYIKSVHSSNRQLAHIASLSILLSPGLLIIDHIHFQYNGFLYGILILSIVLARKQSTLLLSGITFAILICLKHIYLYLALAYFVYLLRAYCLDPKSVFRPQFANIFKLGVCIISIFGIAFGPFAQMGQLLQLKDRLFPFSRGLCHAYWAPNVWAMYSFADRLLIQLAPRLGLPVNQEALVSVTRGLVGDTSFAVLPEVTKEHTFILTLLFQLLPLAKLWLRPDWETFVGAITLCGYASFLFGWHVHEKAVLLIIIPFSLIALKDRRYFSAFRPLAVAGHVSLFPLLFTAAEFPIKTVYTILWLVLFLFVFDQVAPVPERPRYFLADRFSLLYLTVAIPLIVYCSLIHQLIFGLGRLEFLPLMFMSSYSALGVVGSWVGFMVVYFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEW7</accession>
    <name>A0A2I2GEW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_471367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706736.1">
        <property type="nucleotide sequence ID" value="XM_024852831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEW7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEW7"/>
    <dbReference type="GeneID" id="36560529"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471367"/>
    <dbReference type="OrthoDB" id="4336792at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="232" mass="26333" checksum="7E26EF6278C92661" modified="2018-02-28" version="1">MENASRMTRIVDAHARVLEKVLETIGLWRVAQRIRRKLSRYIPLEPRQCEKLKAWIQAHLDLDLTVQRLVQYQWKQEYPPDESASLTSELSSDGDLVSLEYKIAAYRHCASVMQRVLQIELDSFPNGPVKRAIRSLRRNTQWDNSEWVRAQCAERGGCCARQCGCCQAPRRGVAVKGIGHCTSACLCCQNDRGFPIDTSEGDLLGPFRAAGVLNVHDPNLQDPWLKAFVWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEX3</accession>
    <name>A0A2I2GEX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_352196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706732.1">
        <property type="nucleotide sequence ID" value="XM_024843911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEX3"/>
    <dbReference type="GeneID" id="36551611"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352196"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="176" mass="19233" checksum="C93794B08083EA5A" modified="2018-02-28" version="1">MSPPIINFPTLQPAIVWKVNVGAGHPIGPRQSGATLIHFETPTGTVETVEGFEPKFKANVVFGADWLEFDPDQKHARINMKAIARTDDGKEISFGYTGIIDTNEAVLKIFHQQPDSVSVPFGFSTGAHTFHSGDPELQELQNFTLIGNGRMLVDEQTRGITVESRLSKVVPATGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF03</accession>
    <name>A0A2I2GF03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_487309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706762.1">
        <property type="nucleotide sequence ID" value="XM_024853952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF03"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF03"/>
    <dbReference type="GeneID" id="36561653"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_487309"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000028">
        <property type="entry name" value="Aconitate hydratase, hypothetical (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="69"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="588"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="786" mass="85383" checksum="E789594623E6536F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF78</accession>
    <name>A0A2I2GF78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_422544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706837.1">
        <property type="nucleotide sequence ID" value="XM_024847441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF78"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF78"/>
    <dbReference type="GeneID" id="36555140"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422544"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="204" mass="23042" checksum="1E5ED3E97BBFF15C" modified="2018-02-28" version="1">MDPNMNMNMDMDMHHHHQPSTTAHASSTTTPNAHHESSMSMEMSMPTVFTATTQVTILFTGWTTNSVPSYVLTLLVLFVLAILNRFLTAWKSQLERSWNLNQQGQGPKTVTLSAVPRRTGSRIAKERLSPLPRYMRIDEESHTDHHCGHDDNDTGDNGSASLLGRLRKYTPAVERWQASRKWSVRRDGLFSVLECVKAGIGYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFA5</accession>
    <name>A0A2I2GFA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_400484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706861.1">
        <property type="nucleotide sequence ID" value="XM_024846329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFA5"/>
    <dbReference type="GeneID" id="36554028"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400484"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031469">
        <property type="entry name" value="SesB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17046">
        <property type="entry name" value="Ses_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="8">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal death-pathway protein SesB" evidence="9">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="301" mass="32847" checksum="5982990667051B8D" modified="2018-02-28" version="1">MSIRVVREPANAKADIVLVHGLLGDQAPWTSEAGLFWPEKLLAAKAGDGCILSFEYDATISSFFDEDAEINDISGDLINEVMDHRLEKDKEERALIFVAHGLGGTVVENALVRAAQHPKKRELIGYVQGILLLGTPHFQDSSLSAATKYFQFANIPDSEIPAGSDLKEKAHQLISIPPAFSALKQDGAEFEIEGFYAGVKTKAGGKDVKIVDEDLARCPEAPPPEKLARNQLRLSQYDADDDKDFKKVVRVIVQWMSKIVIPEEEKGAQNVSNATFSGSHNSGLQLGQNAGQLKGFSFRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFH7</accession>
    <name>A0A2I2GFH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_422622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706934.1">
        <property type="nucleotide sequence ID" value="XM_024847450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFH7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFH7"/>
    <dbReference type="GeneID" id="36555149"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422622"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014168451" description="Kelch repeat protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="67872" checksum="4608D3A79DA15D10" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFX2</accession>
    <name>A0A2I2GFX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_376894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707074.1">
        <property type="nucleotide sequence ID" value="XM_024845385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFX2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFX2"/>
    <dbReference type="GeneID" id="36553085"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376894"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="355"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="816" mass="90394" checksum="415C4DC304AD7B16" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGB2</accession>
    <name>A0A2I2GGB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_433829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707230.1">
        <property type="nucleotide sequence ID" value="XM_024848586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGB2"/>
    <dbReference type="GeneID" id="36556285"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433829"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="204" mass="22105" checksum="678178EC416D117B" modified="2018-02-28" version="1">MGDHVLFFYGTLMAPQILHRVIHGSPTPEPWQKALLTFRPAVLHGYRRHRVRGADYPGIVPVPAPGSSISTPNSTSSGAGETDTSNAGAAGSVLGTVVSGLTDGDVHRLDIFEGSDYVKEKVCVRVLREALSVEGHDAHDGDGKHLRDVLDAAGAEFADEGEEVNAATYVFIAGEGKLEEAEWDFEAFKRDKMAWWVTADESEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGM7</accession>
    <name>A0A2I2GGM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dimethylallyl tryptophan synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_444111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707330.1">
        <property type="nucleotide sequence ID" value="XM_024850608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGM7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGM7"/>
    <dbReference type="GeneID" id="36558307"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444111"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="412" mass="46485" checksum="7F92EAD7766F17D6" modified="2018-02-28" version="1">MAADRSPWRVLGKALGFANRDQELWWLNTSPFFNNLLNQCGYEVHEQYHYLCFYHKHIVPVLGSFIRPGNSPDHLSCFTPEGYPFELSVNFQEDRSILRLGCGPVGPFAGTEHDPLNKFMTRELLAKAAQIDPAIDLRWFDYFESQFILPTEQARTVSEHVVRHGRQTSQLAFDLKNGGVVAKAYVFVLPKSIATGVPTVTLALNAIEGLADADFGSSLALLREYLLPGPDSDAPRSEVMLIGVDCVEPQSSRLKLYLVNTHLCLENMRAFWTLGGRLSDSTTMKGLEIAENLWNLLGLSDTVYETVDVDKLPLTFNYELKEKEQAPKPQLYLPVQGKGDEFVADALTEFFKFLDWQGFACRYKQDLISNFPCRDLKGSTAVQRWIAFSFTERTGVYLTIYFHAIGGDVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGR0</accession>
    <name>A0A2I2GGR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_350755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707373.1">
        <property type="nucleotide sequence ID" value="XM_024843820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGR0"/>
    <dbReference type="GeneID" id="36551520"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350755"/>
    <dbReference type="OrthoDB" id="4508695at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="148" mass="16309" checksum="7681F31F7CBB02DC" modified="2018-02-28" version="1">MIEPSKTPLSSMPAQWSKASILFKVRSVIRSLLSRLANSLKYSLADEDWEAKACQQFFDAASVLKCCGTPELTLTAYVKLGVVDGASGSGSVQIKLAFNMTQLQNFLTRLASAIMNNTKMFLKPLPDGSTLEVRYIIRMSSSFQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGR6</accession>
    <name>A0A2I2GGR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_433905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707329.1">
        <property type="nucleotide sequence ID" value="XM_024848603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGR6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGR6"/>
    <dbReference type="GeneID" id="36556302"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433905"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="295" mass="32473" checksum="741A46F5080BE0B6" modified="2018-02-28" version="1">MDKIWGTSFHVCRQVPGESFRAAMTRHEHYLALRLGLKPGQRVLDVGCGIGGPAREIARFAEVEVCGIDSCLAHIQRAQALTEPSNLSPGQARFLVRNFTATNLPQGSFDRAYAIEATCYAPDLTAVYGEAFRVLKPGGVFAVYEVALTERYDDQCAEHREILHRMESVAGNPHLKPTVEVMAAMKAVGFELLSAEDLADAPGSFPWYRLIDGSFKRMGGFGETLAGGCLAAFYKTFSSRWGRDLLKYGEMVGILANGRQGHVEEMIQVMQAYCIAGEEKLVTPMFLMVGRKPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI11</accession>
    <name>A0A2I2GI11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_444483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707820.1">
        <property type="nucleotide sequence ID" value="XM_024850635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI11"/>
    <dbReference type="GeneID" id="36558334"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444483"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF23">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="4">
        <location>
            <begin position="279"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="593" mass="66291" checksum="0972C9AFCFFA49EE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIL9</accession>
    <name>A0A2I2GIL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation initiation factor 2, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_434440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708020.1">
        <property type="nucleotide sequence ID" value="XM_024848715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIL9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIL9"/>
    <dbReference type="GeneID" id="36556414"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434440"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="151"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="282" mass="31144" checksum="CD992104F235D43E" modified="2018-02-28" version="1">MDTNGEVTEAPQVEKPTTEAEAPADKSVDEVTEMFKGLSKKKKSKKPKESEGGEGDEASPAADGEFDPTALKKKKKKPKKDTGDFEAKLAEAGATAEAGEEKEEEVPEGDHEAGTGIWAHDASQAIPYSLLVSRFFSLIQSHHPDLLSSGAKSYKIPPPQCLREGNRRTIFANISDICKRMKRSDDHVMQFLFAELGTSGSVDGSRRLVIKGRFQQKQIENVLRRYIVEYVTCKTCRSPDTELNKGENRLYFVTCNSCGSRRSVAAIKTGFRGQVGRRKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ62</accession>
    <name>A0A2I2GJ62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_116619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708218.1">
        <property type="nucleotide sequence ID" value="XM_024842339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ62"/>
    <dbReference type="GeneID" id="36550034"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_116619"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="192" mass="22652" checksum="0BA889E614459038" modified="2018-02-28" version="1">MQMDRSLREQTALFWGFFSLGGNQNSRCQKRINGQLGKARNSNDYEQQGSIRRRETVSLPTRKSCHGAPSIYPTFLYHRPQCKLISSREIRSKVEEERNMLGEDHHTRILVHAKPLGIKSANEITISQFKRQAKDTSLYGRARYSHPRKIGRRHVLNVLRRKENTRKDRGKKKRPSQVWSYKSYKISKTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJW3</accession>
    <name>A0A2I2GJW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_379656</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708462.1">
        <property type="nucleotide sequence ID" value="XM_024845494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJW3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJW3"/>
    <dbReference type="GeneID" id="36553193"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379656"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000073">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="238"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="306"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="399"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="559"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB53160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="619" mass="68862" checksum="E5795B6E8ABF21BA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK03</accession>
    <name>A0A2I2GK03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_404131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708507.1">
        <property type="nucleotide sequence ID" value="XM_024846507.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GK03"/>
    <dbReference type="GeneID" id="36554206"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404131"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1771"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1802"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1842"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1858"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1887"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1899"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1928"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1951"/>
            <end position="2060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2073" mass="233555" checksum="BEF338F9945A66BF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKE3</accession>
    <name>A0A2I2GKE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_454426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708621.1">
        <property type="nucleotide sequence ID" value="XM_024851433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKE3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKE3"/>
    <dbReference type="GeneID" id="36559132"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454426"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF26">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY OXIDOREDUCTASE (JCVI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="248" mass="26397" checksum="B07C6C65852BAA86" modified="2018-02-28" version="1">MPSNVLITGANRGLGLGLAKRYLNLPGQTVIALIRDPSSPSSTSLRTLPKHATSRLIILKYDASIESDAFDAIAELRNTHGINTLDIVFANAGIAKSYPLVKDVTRAEILEHVDVNALAVVSLYQAGRELLEQSTRAEKPVFAIMGSGGGAVGRQPPVPSAVYGASKSLLNWYGVRINAEDEWLNTFILDPGWSATDMGNTAAKGWGLESAPDSVDEVCDGIVKVVSEATKGEIGGKMIKYTGEVMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL24</accession>
    <name>A0A2I2GL24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_473411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708851.1">
        <property type="nucleotide sequence ID" value="XM_024853034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL24"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL24"/>
    <dbReference type="GeneID" id="36560732"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473411"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="619" mass="69380" checksum="7C40345DED35871D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL32</accession>
    <name>A0A2I2GL32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_349555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708869.1">
        <property type="nucleotide sequence ID" value="XM_024843746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL32"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL32"/>
    <dbReference type="GeneID" id="36551446"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349555"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="303"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="654" mass="73490" checksum="0AA30FC0C7AC478F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLX3</accession>
    <name>A0A2I2GLX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_504765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709177.1">
        <property type="nucleotide sequence ID" value="XM_024854227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLX3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLX3"/>
    <dbReference type="GeneID" id="36561933"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504765"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="466" mass="53522" checksum="51E258420CB43C63" modified="2018-02-28" version="1">MQIPLEINLHILKHLVSSLPINRALRIRLVNSLFAEEIPKLLFRHPTAQEDNFILKKWAQFPAPLKRQYIRCKIDMHRTSTCVFSSYADEMLKTELARTSPNLLPSEPAATAVPFIERVIDIAPHMDHDRWDMFHPDRYRRYVEWYETKVMAEFPYQFGSESVEETVQVVLAGSAILRDEVDLLSWALDSGVDLGQVSRRLELSLVDLIARKGSRMIAELVVERGYDLSRVRQFGKTYAALCGAAVGKNFDALDVWLEHLRRRDDAHLQHNLREMMRTAAEKGEFTMLEFLARWYEDGTAALLYNQLISAINEEDISVIRRLMEYEGFYRTISTKKYPKGPLFTVMWIWRSSYFRAILEMLLKGGVDPDGRYPGVVGTPLQRAVEQGWLDAARTLIQYGADVNVLCIPHRMRKRSEVSLLLVAARKRNGAMVRLLLENGADPASVKNDPKHGSYIQRIIDGTETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLY9</accession>
    <name>A0A2I2GLY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_5928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709194.1">
        <property type="nucleotide sequence ID" value="XM_024855290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLY9"/>
    <dbReference type="GeneID" id="36562996"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_5928"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="85" mass="9021" checksum="994D3CE5544C2559" modified="2018-02-28" version="1">MQSPPAGCTPRCMLYRVASLLALVLVISIMHQWPFRDLAHSTSPSTGRSRSRQILASSGTVAQPYGAIGHGPEGLSCPDRVVCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM30</accession>
    <name>A0A2I2GM30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_347423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709238.1">
        <property type="nucleotide sequence ID" value="XM_024843630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM30"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM30"/>
    <dbReference type="GeneID" id="36551330"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347423"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="38"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="536" mass="60938" checksum="0A89D2AE6F7491E4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM44</accession>
    <name>A0A2I2GM44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_504814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709247.1">
        <property type="nucleotide sequence ID" value="XM_024854235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM44"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM44"/>
    <dbReference type="GeneID" id="36561941"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504814"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014122719" description="Glycoside hydrolase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47322" checksum="56A331E0C5332BE7" modified="2018-02-28" version="1">MQFLLAIAALAGSGIISVAQAQSVFAHYMIGETNPDHAKQDVEDAKSVGFDAFAMNVGDPTAEWAQNCVKALFDGAEGTDFNLFFSFDMYQHPDLQGHIDLFNKYSDHPNYMRAGSDNNPVVSSFGGSGEADAWSSFKQNSDIYLIPNLDDSDSSKYFENPEEKLSQFNDFVDGYFSWESAWPGSTGSPVNVSSEGDQKVMEYAHGSNKGYMMPLSPIQYKNTGDGHWYRIGEVNLPQRMTQILDLKPDFTEFITWNDGGESHYIGNLWSESYTTVPEIVEYANTDKFPHFAWQPLIGSFIRAFKDGKSADGMETGSESPIGAMWYRGMTKSCSDQPSNADAARDTVNYAVVLPPLWEGITIRVSSGGNVLTTSPASPGLNYAAVEGMVGGQQKIEVLGKDESVMFSATSGDDVTDGGKCNFNFHVVELSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM68</accession>
    <name>A0A2I2GM68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_451869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709252.1">
        <property type="nucleotide sequence ID" value="XM_024851229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM68"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM68"/>
    <dbReference type="GeneID" id="36558928"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451869"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="98" mass="11764" checksum="55F7B7D4818A4CB7" modified="2018-02-28" version="1">MVYTIVVHMRAKPDEESISKLHAKLIEASGVYSKDKETLSWFVMQSVHDKQDFCIVERYLNEGSQKYHLENPYWKTFDPYVIPLLEKEMDLRRFEEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM76</accession>
    <name>A0A2I2GM76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_6786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709279.1">
        <property type="nucleotide sequence ID" value="XM_024855334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM76"/>
    <dbReference type="GeneID" id="36563040"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_6786"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="87" mass="10208" checksum="0EFE6E9A59DC292E" modified="2018-02-28" version="1">MLLTKKHHRPRIVNKGRREYLSFVNQGSVCWFLPCWIRLCGCTYPVARNGNEADRYRSRIPYFDNKPHFFASILCLVFLESSPAIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMC3</accession>
    <name>A0A2I2GMC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_7018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709329.1">
        <property type="nucleotide sequence ID" value="XM_024855339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMC3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMC3"/>
    <dbReference type="GeneID" id="36563045"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_7018"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="276" mass="31438" checksum="6111C59F901A08DD" modified="2018-02-28" version="1">MSTPPPEDGYTLRRNYMSSMRLNAQHYLWKDAVGSNLHPAISVPNEGKDLRIADIGTGTGVWMTDVNREYPAAQIDGFDVSFDQCPQPQWLPKNTSLRYLDLYQSLPEDLHGAYDIIHLRLFLVVIRDNDPVPVLRNLVKMLKPGGWVQWADHNLESWTVETVSPDVPSPAMEKMRDMMVNTGLGRWVPRLHEIFSQQGLIDVRKDLYQISPHSRLYWTQLQFNSNEEYSYLGMDNSTSDAAGPQYRNLIAQAGEEGRNGAAFNFTLEVTIGRKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN80</accession>
    <name>A0A2I2GN80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_431957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709628.1">
        <property type="nucleotide sequence ID" value="XM_024848156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN80"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN80"/>
    <dbReference type="GeneID" id="36555855"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431957"/>
    <dbReference type="OrthoDB" id="5417135at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="642" mass="70005" checksum="78EBDA2E59D6E61D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNB9</accession>
    <name>A0A2I2GNB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_14891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709651.1">
        <property type="nucleotide sequence ID" value="XM_024842509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNB9"/>
    <dbReference type="GeneID" id="36550206"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_14891"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="82" mass="9395" checksum="255B096DACE2B856" modified="2018-02-28" version="1">MLPSKYTYTQDTPSNFHASWLLFCFFLNFKTFFVSAFDTMNLVDRIGVYLCPFISACLFLILYIIVAIISSPVDDLHLIGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNP9</accession>
    <name>A0A2I2GNP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19">Pyruvate carboxylase</fullName>
            <ecNumber evidence="6 19">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">P170DRAFT_469954</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="6 19"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709795.1">
        <property type="nucleotide sequence ID" value="XM_024852689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNP9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNP9"/>
    <dbReference type="GeneID" id="36560387"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469954"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 28" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="26">
        <location>
            <begin position="41"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="163"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="27">
        <location>
            <begin position="579"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="24">
        <location>
            <begin position="1116"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="660"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="22">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="921"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="23">
        <location>
            <position position="756"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="23">
        <location>
            <position position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00013057"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="PLB54493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1193" mass="131007" checksum="F06B70E6213E0663" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP27</accession>
    <name>A0A2I2GP27_9EURO</name>
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        <recommendedName>
            <fullName evidence="4">GPI-anchored cell surface glycoprotein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">P170DRAFT_421304</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
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        <lineage>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024847349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP27"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP27"/>
    <dbReference type="GeneID" id="36555048"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421304"/>
    <dbReference type="OrthoDB" id="4505596at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
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    </dbReference>
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            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="456"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="557"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="646"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="969"/>
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            <end position="27"/>
        </location>
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            <dbReference type="EMBL" id="PLB54630.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="969" mass="104237" checksum="4BDDE399456F4AB7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">P170DRAFT_452395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1392250.A0A2I2GP81"/>
    <dbReference type="GeneID" id="36558965"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452395"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_V-like_SAM-MTase"/>
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    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250">
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR47250:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="470"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="186"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="600" mass="66631" checksum="627455F77E235310" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPW0</accession>
    <name>A0A2I2GPW0_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">Nucleotidyl transferase AbiEii/AbiGii toxin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_432441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024848264.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1392250.A0A2I2GPW0"/>
    <dbReference type="GeneID" id="36555963"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432441"/>
    <dbReference type="OrthoDB" id="3348320at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22440" checksum="7C5692A4FC508E60" modified="2018-02-28" version="1">MGRSEWLVAFAPIRILTAGGFLAVSYFKCRDSTGDLDYLIEPEFVGDKDIQSALDAAIQNVSFRLEFNRDWVNQAMAIFVTKKTRQTLFEQAEKQGITLFKGENLEVLAAPIEWALERKLRRIHATNRDRKAELDMVDAITFLKHLRERNNGPLDLELVRTMNMNQFDVIPDHRTLQQVADAYRQKYEEEIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPY0</accession>
    <name>A0A2I2GPY0_9EURO</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_505575</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710236.1">
        <property type="nucleotide sequence ID" value="XM_024854300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPY0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPY0"/>
    <dbReference type="GeneID" id="36562006"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505575"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB54934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="248" mass="27270" checksum="BBF722C5DD7C7033" modified="2018-02-28" version="1">MPPKQQTPKRSGPKGLTRLYLILYNALSFTLWASCTLRGIYLLATSVILPLARHEPSAISIDTVTSIANTALPPIFTDIFPALLITQSLATLEILHSLLGLVRAPIFTTAMQVASRLLVVWGVLYLFGGDIVGNAQQGAQTGDAAFLGCLTAWGVTECIRYGFFALQVLGTGVPGWWTWLRYNTFYVLYPLGITSECVLVVKALAPAGEFEPLYRWFLIAVLGIYVPGSYILYTHMIAQRKKVLKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQA1</accession>
    <name>A0A2I2GQA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_432591</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710359.1">
        <property type="nucleotide sequence ID" value="XM_024848297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQA1"/>
    <dbReference type="GeneID" id="36555996"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432591"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="98"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="167" mass="18830" checksum="C995494A501A208B" modified="2018-02-28" version="1">MGLTDFFSDMISSLSFPEAQAEAPAETAEETPSQETQPEEKSAASEESTADESSEKTEDSAEETPAEEASEEEPEKEEEEEAEEEEEEEEEEEEEPEDIKPQLEEECANSSQCAPAKHHFDECVERVTQQQEDEDYKGPKEDCVEEFFHLAHCATECAAPKLWKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR93</accession>
    <name>A0A2I2GR93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear polyadenylated RNA-binding protein Nab2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_461272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710685.1">
        <property type="nucleotide sequence ID" value="XM_024852021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR93"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR93"/>
    <dbReference type="GeneID" id="36559719"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461272"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.40:FF:000001">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="502" mass="54500" checksum="B4F97B8A0696D619" modified="2018-02-28" version="1">MTTMVAAGTPLAEALANTIQPKLVEMGWSSDSGDDSALIEYVILMLVNGKTQEQIAGELSNDLLGLGEGDTQALDFSRWLFEQVESLNHQINGGGVSTTTEADSMQTIPSFADQDVSTPSQPMAQDGAMDADMSMGDGGFANDAIPTGPKAMRNGRQGGRGRMLNQINRAMDRADAPLHRIRGQSGAGAGRINAHGRDNQKGRFQNGGGRMGGGRQMGGMGMNPNQMAAAGNMMNMPPNDQMHLMSLLEEQARMMAQFMPGFVSPAINPAFQPNAPQHGRSLFDRVERQHGRRQQGSYNNRRDKPADVDMDMKPDQTQDGEPDENNANSVCRFNLRCTRKDCPFAHQSPAAPDGAPVDVSDNCTYGAACKNRKCTGRHPSPAVKSAHQAEELCRFFPHCANPHCHFKHPDMPLCRNGADCSVAGCKFTHVQTPCKFNPCLNPSCPYRHEEGQRGAFSDKVWTAGEEKPHVSERKFVADEDAEELIKPEGPTDGSSQNQEIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRE0</accession>
    <name>A0A2I2GRE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chaperone/heat shock protein Hsp12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_506040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710744.1">
        <property type="nucleotide sequence ID" value="XM_024854348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRE0"/>
    <dbReference type="GeneID" id="36562054"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506040"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9410" checksum="D670E942C7C63A2D" modified="2018-02-28" version="1">MSDSGRKDFTTKAKEELTPDSMKSTQDKTKEAATDTTDRIARGFQSDEGKSGPQEAFDKGQRAHDNHEHGGATESVGDKVKGALGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRS4</accession>
    <name>A0A2I2GRS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_45118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710884.1">
        <property type="nucleotide sequence ID" value="XM_024851172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRS4"/>
    <dbReference type="GeneID" id="36558871"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_45118"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="32796" checksum="218C51785FE4DA18" modified="2018-02-28" version="1">MSPTIHCVRHAQGVHNLSTANHVIHDPLLTDLGNEQCRQLRDAFPYHEKIDLVVASPLRRTMYTALQSFEPFFKANPDKKLLLLPDTQETSDVPCDTGSEPEVLKREIEEKELPVDLQYVVEGWNDKVGRYAPTNDAITDRARDARRWLKERPEQNIVLVTHGGFLHFFTEDWEDSSQYQGTGWLNTEFREYVFSIEFHTEDLDGKALAGDNASLVETVDSRARRGKEGPMAGRRRQSTLYKLGTQDWDDQGLQLSSAEREVLKNIDPNGFQRIELDDCIHSVAKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRU6</accession>
    <name>A0A2I2GRU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_443341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710898.1">
        <property type="nucleotide sequence ID" value="XM_024850539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRU6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRU6"/>
    <dbReference type="GeneID" id="36558238"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443341"/>
    <dbReference type="OrthoDB" id="3029470at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="200" mass="22754" checksum="0262C6AA2C0D2943" modified="2018-02-28" version="1">MPEVIDPWYIHIFTKTDLERATKFPPGCFAFEFLKAITSRPAKLHYIAPGLRLPTASEISEFLGPKHDKDFLEWRYNLVRWPPHYRGIVRTGLYITEAVTINESAFGDGCTLTLPFKVGANGWARRSNGEPIKGCTYEDACAHAELYQTQGIGFNDGHSVQIYKDDDWEVGEDGVLGGPEKFKDSDSEEHWHKYWIPPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSF6</accession>
    <name>A0A2I2GSF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_347197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711102.1">
        <property type="nucleotide sequence ID" value="XM_024843612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSF6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSF6"/>
    <dbReference type="GeneID" id="36551312"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347197"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="272"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="569"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="656"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="917"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111176" checksum="A43336901C2F7117" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSF9</accession>
    <name>A0A2I2GSF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_484946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711111.1">
        <property type="nucleotide sequence ID" value="XM_024853919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSF9"/>
    <dbReference type="GeneID" id="36561617"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_484946"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="79"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="36064" checksum="5138CD8590C57184" modified="2018-02-28" version="1">MKFSKMKTPPGFTHLHVLDHLLKPCHKSSPTLKMTYKSSEKSFNPQGSGESSKGSKSLSSILEQLQSLELGDPKPSSKFIDTTESLAELLDSLHDLPTSPQPSIYVDMEGGSLSRNGTISILQMYISPRDEAALIDVHNLQNKAFSHASSKGWTLRKVLEDPSIMKVSFDVRNDSDALYRRFNVRLAGVHDLQLMELARRSSSKRYLSGLAKHIESHARLNGFELEKWKDAKFDGRKLFEPQLGGSYEVFNVRPLPDEVREYCVLGVRSLPKLWRLYYLGLTGSWYQRALEEAENYIRETQAPEYVSNGRSKVLGPVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSJ5</accession>
    <name>A0A2I2GSJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">U2 snRNP component prp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_471249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711153.1">
        <property type="nucleotide sequence ID" value="XM_024852822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSJ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSJ5"/>
    <dbReference type="GeneID" id="36560520"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471249"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="247"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="781"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="1018"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1233" mass="136866" checksum="63DD78BF1A08AC3F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSN4</accession>
    <name>A0A2I2GSN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1665 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711172.1">
        <property type="nucleotide sequence ID" value="XM_024848467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSN4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSN4"/>
    <dbReference type="GeneID" id="36556166"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433346"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="98"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="67753" checksum="FC1AA2189D400BEE" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSP9</accession>
    <name>A0A2I2GSP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_422391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711204.1">
        <property type="nucleotide sequence ID" value="XM_024847428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSP9"/>
    <dbReference type="GeneID" id="36555127"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422391"/>
    <dbReference type="OrthoDB" id="4505338at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="231" mass="25114" checksum="F89E5CC9B170B042" modified="2018-02-28" version="1">MVFPRILTSFSRSYSSGSGSIFKSPSPNDRREEVRSSSPSSSTSTIQPLKRNEESEDITPTDAYTPRDYSAASKPEEREAKKESENADGWSYGPESDNSDISTLDLGPSITTSPATPKASTPLATHPEYPLTPLPGSESQDDPFDQVKPLEREPDSKSAVGPEESNQRVNNVPAHREEQAETPVRPPKRKSDTVVATFRTLSSSGSSLFAGLRPGVNRARTSFRRGGVLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQI0</accession>
    <name>A0A2I2FQI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_371039</name>
        <name evidence="2" type="ORF">P170DRAFT_371251</name>
        <name evidence="1" type="ORF">P170DRAFT_490913</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000021">
        <property type="protein sequence ID" value="PLB42869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000021">
        <property type="protein sequence ID" value="PLB42879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000018">
        <property type="protein sequence ID" value="PLB42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371039"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371251"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_490913"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="207" mass="22874" checksum="A14036F282711072" modified="2018-02-28" version="1">MTRHLATLRDQIPLVRTSSKLVVKRPPDGRSLPRASPARCWGAPAGCPASAPLLRGVPPKAQRARPLEPILIPKGCSPWRPAAVMSTTWRENYSFPRIFKGRRGRTGPCKGAGLCQPWNPSSGQTDFRDRLTHVQLLFTWNLSPLQSSKFSFEYLLLPPRSALGAVRPGITPKASSRTPTPAYSSGHRFYPDGEVWVTRLSAIHFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR92</accession>
    <name>A0A2I2FR92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Silencing information regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_441579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698428.1">
        <property type="nucleotide sequence ID" value="XM_024850345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR92"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR92"/>
    <dbReference type="GeneID" id="36558044"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441579"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="384" mass="41878" checksum="0ACC4DE8874745C1" modified="2018-02-28" version="1">MTTPSIRIPFTGALPPPIIFPPSARTVSGAIDALLSFFAAPPSPYLRGVDVGRHSQAVLLTGAGISVASGLSDYRGENGTYITNRTYRPIYFHEFVTRHESRKRYWARSFIGWPGLVKAQPNSTHRAIRDLSAKGYISSVVTQNVDSFHSTAHPDLATVELHGYLRSVVCTSCRNQFSRAEFQESLQKLNPAWAEFLARMVDTGALDTDNPEERRRKGLKLNPDGDVDLAEAPYSTFRYPSCPTCLEKAPRLADGTPGRVDVESDGAWLPTSTAGILKPAVTMFGENIDPVVKATAEEAIDDAGRLLVLGSSLATYSAWRLVERAYRRGMPIGIINLGGVRNESLLFGEDGKEQHVGSTYIRCSLSSESVLPSVASQLSSLGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRZ2</accession>
    <name>A0A2I2FRZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698704.1">
        <property type="nucleotide sequence ID" value="XM_024850402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRZ2"/>
    <dbReference type="GeneID" id="36558101"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441803"/>
    <dbReference type="OrthoDB" id="4478691at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="352" mass="39619" checksum="60E60103BD88C476" modified="2018-02-28" version="1">MDPLRYLAAPQPFKAITEASSKEIKARIAFVDSLLAHPRLDVSESQHEEFVMYREACEILAEGESSEDNQQTLQQGATALEAKLVPQTDGATDVNLSFDLATKTKMGEEVDNLWNMWSFVRYEKYLPAQAMKGDDETKREASQAGDPWHRAFWKPFQGRLEAESEAFARVLKGENAHNECPTYLLLALLTERHTLDWDETLALIKACAGSEEGETVEMPGADIVELIRARDTTALAKRLDHDEASISLSAEYVMGVPAMVLAFFGTHLPEALFDTDDFDSAQWKPKQRLEDLLQMTEGQEEAVKALMSEMYDAMLEDDSSDDFEDEEWVDDEDGEDDLLDETAFSDGSEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSI7</accession>
    <name>A0A2I2FSI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_513950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698910.1">
        <property type="nucleotide sequence ID" value="XM_024855164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSI7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSI7"/>
    <dbReference type="GeneID" id="36562870"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513950"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="532"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1039" mass="113883" checksum="FFCDF60FCA2A8228" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSS9</accession>
    <name>A0A2I2FSS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_441128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698973.1">
        <property type="nucleotide sequence ID" value="XM_024850241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSS9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSS9"/>
    <dbReference type="GeneID" id="36557940"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441128"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="68"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="173" mass="18584" checksum="D2E4C83CC1B5C23D" modified="2018-02-28" version="1">MSAVARSIRPFASRALSQKLPLAAARRVSPVMGFPRGSIRSFSQSPFMEVKKYTESHEWIELADNGKTAKIGITEYAAKSLGDVVFVELPQEDLEVSAGEPVGAVESVKSASDVLSPVSGKVVQGNAILEDKAKFINESPENEAWIAEIEVSDAAELDGLLDAAAYKESLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT91</accession>
    <name>A0A2I2FT91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_441306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699157.1">
        <property type="nucleotide sequence ID" value="XM_024850284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT91"/>
    <dbReference type="GeneID" id="36557983"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441306"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="558" mass="61527" checksum="F81559CEFB80D7DE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU74</accession>
    <name>A0A2I2FU74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_392255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699484.1">
        <property type="nucleotide sequence ID" value="XM_024845968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU74"/>
    <dbReference type="GeneID" id="36553667"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392255"/>
    <dbReference type="OrthoDB" id="4960444at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="381" mass="41490" checksum="A8396E84919D4E8E" modified="2018-02-28" version="1">MATSMSSATVHQKLSRQASSPPTFRACLQSIALLSEPERKVLVESAAKYHLSPADEEAFTTAAVQALASDDLDGELGDAANGASAAVNGIIELMVALVLNLAWADTMNGTNLTDQYEPIMRLYCQTMKDGIPLSNTIAQYAEDFDNKVIAFCADTSLTTDQRLSQIQEYIKDAEASQTTAQDMQNTLNSVFDKTMDFINMVNSDSLKKEATEKTFPVPKSAKKLADVSPKLEIPALTAAFDSPFGPYVTIAGLLGIHSTEATNTAYAIAAAMSNRERVPMSKVLKDLATQDGADDTNTEYFNEFREHIGVLAGYWGSTLIDARQIEAWLKDGAAVADMPKYMEIALNGGVKIYVKVAKYLRSYAEQTNQIPWDEWLSADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUI5</accession>
    <name>A0A2I2FUI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_480047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699586.1">
        <property type="nucleotide sequence ID" value="XM_024853751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUI5"/>
    <dbReference type="GeneID" id="36561449"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480047"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="493" mass="53845" checksum="D498377798DBEB90" modified="2018-02-28" version="1">MVAADISRAPNVCANCKARKKRCDKSLPRCRYCADRNLACCYQTSSSSPRRPIADPVFVSSASSSPSTVWRGASVVPTSIPRLPFDSLAPEIEPGLCVQAQRLLETTGLYLDEISVRYFRGIHTFVPIVSRRRFQAHLLSFGVNPQADFALLLLCMGLLTYSADSPHPAPPGGGRVENRMLYVATKSLMAQAQALCQPSTQLVQAGVLLAVYEYANGNPETAFITIGSAARMAYAARLRSVSLLSTAPPRTDWTAEEEEINIWWGIRVCERTFLCELPIVEQPLGSVMPARDDRLPLESSVLDHGNPSAALASSVAIQDLSAPQVGGFGRAAQAAWLLDGVLQGLSLTDADRKRTHLADCDRTLQSLLAIVMQQMQQQGGNYGPFCVATALTIRALFLLHWHLLDQPTYESPGSDSPVNSSHSALDTVTQMVIDICITHEHMSISQIDQLPPSCLYIIRASMKHMQSPTPDPRLYASLKQFEARWGASSAFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVZ4</accession>
    <name>A0A2I2FVZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_391153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700079.1">
        <property type="nucleotide sequence ID" value="XM_024845932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVZ4"/>
    <dbReference type="GeneID" id="36553631"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_391153"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="68"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB44777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="589" mass="64057" checksum="EEB847C0FDF5344E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW73</accession>
    <name>A0A2I2FW73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_365925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700180.1">
        <property type="nucleotide sequence ID" value="XM_024844734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW73"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW73"/>
    <dbReference type="GeneID" id="36552434"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365925"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013987807" description="Cutinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB44878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="222" mass="23033" checksum="E29BDD8D9BE79C81" modified="2018-02-28" version="1">MVTLRSILIGALATLAVASPIAEPDHSLEARQLMDSNDLQSGQCKDVTFIFARGSTEMGNMGTVIGPPTCSGLKAKLGAGKVACQGVGGMYTAGLAQNALPQNTDPGAINEAKKWFNQAAQKCPDTQIVAGGYSQGSAVIDNAVQGLSSDVKDKVKGVVLFGFTRNLQDHGQIPNYPKDQVKVFCAAGDMVCTGTLIITPAHLTYGLNAGEAASFLQSKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWA8</accession>
    <name>A0A2I2FWA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_415790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700224.1">
        <property type="nucleotide sequence ID" value="XM_024847082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWA8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWA8"/>
    <dbReference type="GeneID" id="36554781"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415790"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="619" mass="69003" checksum="694934B7192494C2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXE6</accession>
    <name>A0A2I2FXE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_479820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700606.1">
        <property type="nucleotide sequence ID" value="XM_024853722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXE6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXE6"/>
    <dbReference type="GeneID" id="36561420"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479820"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF37">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014151812" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB45304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="456" mass="50132" checksum="84A7AFFB891767AA" modified="2018-02-28" version="1">MRYLPWAPLLTVLLAGQAAVSQIQLDVGDPKSIKNAAATSAYNMMNNYHGNESGQIPGKLPDTWWEGGAMFMTLIQYWFWTGDTSYNEVTTQGMLWQKGNNDYFPANDSNFLGNDDQVFWGLAAITAAELNFPEEDGQPSWLSLAQGVFNTQVPRWDTSACQGGLRWQIFPYQAGYTTKNAISNGGLFQLAARLGRYTNNETYTEWAEKIWDWSATTPLLKMDEWTIADTTTMETQCTDHGDLQWTYNYGTYLSGAAYMYNLTNGGVKWKKAIDGYLGTTLDKFFPKEFGGNVMSEISCEPNMMCDRNQDCFKGFLSSWLTFMTTIVPHTANQIIPKIQASAQAAAKQCSGGSTKTQCGRRWHQDSWDGSKGLEQDMSALSVFASSMITHKPQGHSPLTADTGGTSKSDPTAGSGPQKQPNTPRPITTGDRAGASILTVVVAGGWLAAVAWMVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXJ5</accession>
    <name>A0A2I2FXJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_467859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700634.1">
        <property type="nucleotide sequence ID" value="XM_024852497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXJ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXJ5"/>
    <dbReference type="GeneID" id="36560195"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467859"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="107"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="313" mass="35111" checksum="E0E6AFE1BFF17D18" modified="2018-02-28" version="1">MSTTREFDPNFTPYVINSMGPKTPERTRVLLGSLIKHIHEFAREVELTPAEWMLGVEFINSIGKISTPIRNECHRICDVIGLESLVDEIANKIVTEQGVSPTSNVILGPFWSPNAPFRSLGDSIIQNPNPNGQVTYMHGVLKDMETGAPIEGAVLDIWQASANGQYDFQDPNQTENNLRGKFRSNEKGEFWWYCYHPTPYSLPTDGPAGVLLNLMDRSPMRPAHIHLMITHPNYATVINQIYPSDDPHLDIDSVFAVKDDLVVDFKPKTDDPKASLDLEYNVNMALKKHHPNPNSAPPVSSFERHNKAASQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXU1</accession>
    <name>A0A2I2FXU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_244291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700753.1">
        <property type="nucleotide sequence ID" value="XM_024842971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXU1"/>
    <dbReference type="GeneID" id="36550670"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_244291"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014173980" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14471" checksum="C52B351B19B12060" modified="2018-02-28" version="1">MSSWDSCVMLTFILFKVFGDVGDGDIHLNARSSLFSPNQHPAVSHLAFSKHLHCLLDTLPSQRKGLGCREYLLLRCKFQQSSSTVARGNQRALNPNTLEAQLQRGNRRRLERRSQRINGAGRIHEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYB1</accession>
    <name>A0A2I2FYB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_512272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700914.1">
        <property type="nucleotide sequence ID" value="XM_024854975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYB1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYB1"/>
    <dbReference type="GeneID" id="36562681"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512272"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000050">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="692" mass="77602" checksum="4732CB4751049506" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYH8</accession>
    <name>A0A2I2FYH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700992.1">
        <property type="nucleotide sequence ID" value="XM_024849829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYH8"/>
    <dbReference type="GeneID" id="36557528"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439424"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014131007" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8815" checksum="A9554DEF20E90FAF" modified="2018-02-28" version="1">MGSMDCDLWLLMHILLFLHFPWVVSEAYPHPPITPIPIHLQSFLHRRVSAVVRGILRYGATTLRGAVPAGDMPVLGGTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYQ3</accession>
    <name>A0A2I2FYQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase I subunit RPA34.5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_458023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701057.1">
        <property type="nucleotide sequence ID" value="XM_024851758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYQ3"/>
    <dbReference type="GeneID" id="36559457"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458023"/>
    <dbReference type="OrthoDB" id="76224at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33775" checksum="09B7C40B5ED59966" modified="2018-02-28" version="1">MAPKSASSSSSESESRSSSPEVTKKTTQASSSESEEDSSSGSSEGESDNESAASSKEESDNESEESSDESSKVKTIAAQPFKAPSGFRSVKKQSPPSSSTASALSDLRGKQIFHVSAPAFLPLSKVKEISLAKVLQGEPVMKHEGVAYGIPAESMSNGDVAGQTLLTYDPKTQTYTSTTADNIQSYHVQELAQLPERSETEGKVRAAAQEQVVPPRKQPKHLKMRFRPVGSRNAPAETIGSSSEESEGEAPTFKVPKGAKVDKEERKRKQHPTEGEGNTASGEPRKKSKKHEDGEKKKSSKSKEEKKRKKSGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZD0</accession>
    <name>A0A2I2FZD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701286.1">
        <property type="nucleotide sequence ID" value="XM_024849895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZD0"/>
    <dbReference type="GeneID" id="36557594"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439683"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="104" mass="11737" checksum="D01740744F0F802E" modified="2018-02-28" version="1">MTRSGAIRHCLMDSLAAVHPCIAPMWRWICALCFFSPASARRMALYGRLKGLSDELKLLPLEKDTHSPQYFLCCVPSFPSKFPLSLYFPLFLLDQCGFHQTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZM2</accession>
    <name>A0A2I2FZM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_259680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701381.1">
        <property type="nucleotide sequence ID" value="XM_024843070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZM2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZM2"/>
    <dbReference type="GeneID" id="36550769"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_259680"/>
    <dbReference type="OrthoDB" id="4487712at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56463" checksum="BAE3C4D8EE35B4D0" modified="2018-02-28" version="1">MQSRPLQSANTDSVEPASSSFSIFSPEGLKWLCDKAGYGTIDIEDFDSPLHPENKFIDDDPMADAFLTQPFIELPPKSVAMQLFNTYFREMNPFCPLFDENEFMSRVEYDYPIYPQSSPSWWACINATIALSCAFETGLYSKAWLYWKNATLSLNSFFIERPQLSSAQALLAMTAYLIGTFSATPSQTFVSLALRILHGLNPAEYERSPAYRRVLAITYDLDIDISLRSATPPTQPIPTVSLNTLFDDRINHKNSNSSNNNFATSYIFDLFDSYTGLTTLKSHVYRELYSATASDKSDPEIIAIVGQLDTLLEDWRNGIPLDYRPEVARPDDVIRRDPHMSIFYVHFSYYSCILAIHRKAISRATWSMNLDPRSCRLPPLRSPNPRTLISTQLCVQAARKSMELVQHLPQHHKLFGGSIAYCVMFALMILSMLIVQDPQVARGNTDIELMRAVESFFSDISMIRSDENISNFVQCCARYRSIAETAIKQSRKGMLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G053</accession>
    <name>A0A2I2G053_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701567.1">
        <property type="nucleotide sequence ID" value="XM_024849938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G053"/>
    <dbReference type="STRING" id="1392250.A0A2I2G053"/>
    <dbReference type="GeneID" id="36557637"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439889"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="252" mass="29762" checksum="EB6BC241CF009F50" modified="2018-02-28" version="1">MRRLKRPNYLLDVMIVNEWDFWPTWLSVPVLRTHLDEVNANFRIFGHCLSGDKVRWITGDGGHDGPEWCFYAMLERFLVHGPLTEPSKPKKQTGRKFYIKTLTLNFESAAGDQYYLAPSTVRRRLWAQFKHLDDPEECLDLSLYAPRPEWPAKILYSELVSLLRLSEYIPSYGLMFFEHIGKMRLLVEGRLYQEFDITAIMAPNTFNSTMSNFSRTEGREDFWRWKLDTLRKRQEAGLPVIWSDDPGLDRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0B0</accession>
    <name>A0A2I2G0B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_457029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701627.1">
        <property type="nucleotide sequence ID" value="XM_024851677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0B0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0B0"/>
    <dbReference type="GeneID" id="36559376"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457029"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="316" mass="35415" checksum="32229DFDD4B9C3D0" modified="2018-02-28" version="1">MEAAREAHQKSTGHAFCKLCNRHFDNDTQLKRHEKDSHAVQFHCCLCDKDFVNNTALVQHLADKIHPISEASYRCEACDRTFRNQRSLEQHQLSPAHRPLANLTCLTRSCPVRFNCPSALIHHLESGRCSSGWSRQSINSVLHQYDINRVITSETVSLETSTAHPLEDSSSTSSGSPILTPSDSSMLDGDEWMAVAHPNDQAGKLQVAQAELQTSLHCFLCAEKGITRGFKSLKALQDHMSSPAHESRSFKCPLAFTVDGWEESAVHSRTFTTLSGLTQHLESARCRGGKPTLWKLLDYLKTDILRVEWPGRLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0E3</accession>
    <name>A0A2I2G0E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_438172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701654.1">
        <property type="nucleotide sequence ID" value="XM_024849527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0E3"/>
    <dbReference type="GeneID" id="36557226"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438172"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="74" mass="7977" checksum="66BA47A3A846F44E" modified="2018-02-28" version="1">MANVGGFQVRASTDHCCTMTWHAVAAPGIWLLMSSSSIAWGGESGFDSDGSNRGSFLYPLQWAVVQQEEPRKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G152</accession>
    <name>A0A2I2G152_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_511319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701901.1">
        <property type="nucleotide sequence ID" value="XM_024854877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G152"/>
    <dbReference type="STRING" id="1392250.A0A2I2G152"/>
    <dbReference type="GeneID" id="36562583"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511319"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="184" mass="21960" checksum="F1DAA73233D20564" modified="2018-02-28" version="1">MRIENCFFCSRPTYPSKGITFVRNDAKAFRFCRSKCQRAFTKKRQARKVKWTKISRQHAGKEMQVDRTLQFSARRNVPTRYNRQLMAQTLHAMERVEEIRARRERVFYKKRMAGNRERETADNFKLVSENEHLLPRELRENAETKVAELQPAKSKVFKTERRKLRARVDGGVEEVVEDNTMDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1I2</accession>
    <name>A0A2I2G1I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_363620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702018.1">
        <property type="nucleotide sequence ID" value="XM_024844588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1I2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1I2"/>
    <dbReference type="GeneID" id="36552288"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363620"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="215" mass="24230" checksum="902C4606CAA56CB9" modified="2018-02-28" version="1">MRTFSFLVTLVAALIGFYNYFEARLESFYIFDPSHLHDLSQRAIAAHGENTRGVVDFIVAELEQKVPSVHINKDEEWVFNNAGGAMGAMYIIHASITEYLIIFGTAIGTEGHTGRHTADDYFNILQGTQLAYVPGSFEPEVYPAGSVHHLRRGEVKQYKMDSSCFALEYARGWIPPMLFFGYADTFSSTLDFPTLWATSRITGREMISNLFKGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1S5</accession>
    <name>A0A2I2G1S5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptide hydrolase</fullName>
            <ecNumber evidence="18">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">P170DRAFT_448577</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="18"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702132.1">
        <property type="nucleotide sequence ID" value="XM_024850975.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G1S5"/>
    <dbReference type="GeneID" id="36558674"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448577"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000251">
        <property type="entry name" value="Ubiquitin ligase complex F-box protein GRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 18" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="13 18" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1015"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1049"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1081"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1107"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1240"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1277"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1305"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="24">
        <location>
            <begin position="170"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="21">
        <location>
            <begin position="737"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="23">
        <location>
            <begin position="1016"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="22">
        <location>
            <begin position="1332"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1148"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1168"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PLB46830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1544" mass="171436" checksum="1F3A5239265A581C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1T0</accession>
    <name>A0A2I2G1T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_224100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702137.1">
        <property type="nucleotide sequence ID" value="XM_024842876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1T0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1T0"/>
    <dbReference type="GeneID" id="36550575"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_224100"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000073">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="581" mass="65845" checksum="9B6E05BE6D50C294" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1T9</accession>
    <name>A0A2I2G1T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702147.1">
        <property type="nucleotide sequence ID" value="XM_024849622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1T9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1T9"/>
    <dbReference type="GeneID" id="36557321"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438549"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24867" checksum="2CA666119F44B43A" modified="2018-02-28" version="1">MPWMSILINHAVTEEGLDSKLTLHYYARMRFIWNLLPQLTKAGEEVSQPQLQSQPLSRVISVLEAGGESPSLDLSDLSLTRTFTLRNCAKHAITMTSLATEHLALTHPGTSFVHVFPGIVQTGLMRDAGGVARFAVSVLAKTLARPWVVPVEESGERHLFVATSPEYQAVGEKGGGGYLLNWDGTPRGNEKVMAEFREKGTAEVVWKHTMEVFERIRGRGQDGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1W5</accession>
    <name>A0A2I2G1W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_477733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702174.1">
        <property type="nucleotide sequence ID" value="XM_024853498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1W5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1W5"/>
    <dbReference type="GeneID" id="36561196"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477733"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF113">
        <property type="entry name" value="MEMBRANE PROTEIN, MPV17_PMP22 FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27164" checksum="D172CE23109DC26E" modified="2018-02-28" version="1">MLIPQGLLACRHEAMLTRLRLRLPNRIPVNHHHTRTKQDDAVPRGPASRPMARKPQRPIASIFEWFSRSQSRRPYITQLCLTPLIFCLGDFSAQMIGDDDFDYHRSLRSVVIGLVIAIPSHEWFLFLGRCFNYSSPSLSLGAKVAANQAFYTPMFNVYFFACHGLLAGEGLWGAVERVKEKASISIPRSFLFWPVVTAFNFSYIQPQSRAIATAMFSVFWQSYLSWLNSSAGEGKASRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1Y3</accession>
    <name>A0A2I2G1Y3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_225937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702186.1">
        <property type="nucleotide sequence ID" value="XM_024842880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1Y3"/>
    <dbReference type="GeneID" id="36550579"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_225937"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014185255" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12195" checksum="1A4FAFB4F35D0C27" modified="2018-02-28" version="1">MPSLCFLPFTFLMIIQSSIMRPCNRDQRSFIYHLQEKLGFSFLSFSFLLLVSWKFGTINRTRTVSFSRPLSACVFTFRLFFVRFLDGLINIPPSSRPIHTSSSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2B4</accession>
    <name>A0A2I2G2B4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidic acid-preferring phospholipase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_457411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702313.1">
        <property type="nucleotide sequence ID" value="XM_024851717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2B4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2B4"/>
    <dbReference type="GeneID" id="36559416"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457411"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055555">
        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="614"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="901" mass="101170" checksum="2439F4E33AC7B3A1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2V1</accession>
    <name>A0A2I2G2V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_466514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702502.1">
        <property type="nucleotide sequence ID" value="XM_024852423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2V1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2V1"/>
    <dbReference type="GeneID" id="36560121"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466514"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001872">
        <property type="entry name" value="PAXNEB protein superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="396" mass="42249" checksum="1CBE178AF07D6C2F" modified="2018-02-28" version="1">MSFRKRNIGLSAGADRASGQNPTAPVLQAAAAPESNPGIRPSPDDGRPTTSTGAPSLDNLLAGHGGLPIGKTLLIEENGTTDFAGALLRYYAAEGVVQDQRVHVVGMPEQWGRSLPGLIGPAEAADDKQDKRKGEKMKIAWRYERLGEFGTGVAGSRDTASAAPTGDQSQQTGNQAEQPAFCHAFDLTKRLTHPGITNITYVPLAPSKEPLFVSVHKRLQAAIAQSPPNTVHRIILPSLLNPTIYPPEVCQPENLLPFLHSLKALLSSPNVRATAMITMPLSLFPRSSGLVRWMEILSDGVFELCPFPHSADALAASGAATAHEEPPQGMLKVHRLPVPHERGGGSDQNIGQDWAFTLSRKRFEVKPFSLPPAEGDKEAQDGAAAGGMPKKADLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Y9</accession>
    <name>A0A2I2G2Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_412991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702542.1">
        <property type="nucleotide sequence ID" value="XM_024846950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Y9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2Y9"/>
    <dbReference type="GeneID" id="36554649"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_412991"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="68"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="385" mass="41498" checksum="64BB23ABAA90B0E8" modified="2018-02-28" version="1">MSRNRILTSPSHLTSLLRPSTIATPSPSAARLSAISGHLRPSPLTQPAQARKMSTPSTMKAVIAEKIGGPEVLEFKTDHPVPTPKEGQLLVKNNISGVNYIDTYFRTGLYQSPKPEILGREGAGTVAAVGLGPNPFNFKVGDRVAWLTTGGYAEYTAVPADRTVRIPNGVSDEDAIASFLSGMTVLSFSRETYNVQKGDWVLLHAAAGGAGFLMTQLLKAVGAKVIGTAGGPEKVALVKSLGADVVIDYRSEEGKDWVKIVKEVTGGQGVDVVYDSVGKDTWEGSLEAVKRKGTIVWFGNASGPVPPIALPKLSPKCVKIARPTLFGYIETREELEYYVNELFNLLKSGQLKVKIHKVYPLEQVAQAHRDLEGRKTTGKLLLKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G324</accession>
    <name>A0A2I2G324_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GDPD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_363515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702559.1">
        <property type="nucleotide sequence ID" value="XM_024844578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G324"/>
    <dbReference type="STRING" id="1392250.A0A2I2G324"/>
    <dbReference type="GeneID" id="36552278"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363515"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08606">
        <property type="entry name" value="GDPD_YPL110cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="818"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="902"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1189" mass="130878" checksum="251074D4E380B1BF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G379</accession>
    <name>A0A2I2G379_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_363137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702633.1">
        <property type="nucleotide sequence ID" value="XM_024844558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G379"/>
    <dbReference type="GeneID" id="36552258"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363137"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="269" mass="28944" checksum="52052D8E42AA46E8" modified="2018-02-28" version="1">MPSYLITGASRGLGFEFLRQLSADPNNLVIGLVRNKPATEEKVAAEFPGRNVHLVQGELTDYEALKNAVSEVEKITPSLDHLIANAAHVSSWSAYDGIGDLAAKSPQELNNDILESIRVNVLGNISLFSLFLPLVQNGTAKKIVTITTGMADLELISAFDVVAAAPYSISKAAMNAAYAKFSAQYRKDGVLFMGVSPGLVDTGNYEATPEQLAGMQEMVKQFATYAPGFKGPITPEESVGFVLETIHRAEISKGYAGAFVSHYGNKQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G382</accession>
    <name>A0A2I2G382_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_448968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702637.1">
        <property type="nucleotide sequence ID" value="XM_024851007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G382"/>
    <dbReference type="STRING" id="1392250.A0A2I2G382"/>
    <dbReference type="GeneID" id="36558706"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448968"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000014">
        <property type="entry name" value="PUS4p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="392" mass="43556" checksum="6F45F6C5C016DC10" modified="2018-02-28" version="1">MSGEKIYEGVFAVHKPQGVSSADVVRHLQRNFNRSKLFEPWLETERARRERESQFQRRRRRQQALDVKIGHGGTLDPMATGVLVAGVGKGTKFLNSFLGCTKSYETVVLFGAETDTYDRLGKIVRRGPYEHITREAVEKALEQFRGKIMQRPPIFSALKVNGKPMYKYAREGKEIPIEIQDRPVEVTDMRMVEWYEPGTHEYQWPEVEAEGEEKEVAEKLLARDATVSVVSEAEGAASNEQPEASSTKRKSPPPAESAEEGAADDAATPAEAPTSKKQKVSAEGDEAAAEQPASPSQTNEKPAQPQPAAVKIVMTVTSGFYVRTFAHDLGKAVGSCGLMSSLIRTRQADFELEPEKVLEYQDLEAGEEVWGPKVKGFLDQWEKKRAAEESGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3U7</accession>
    <name>A0A2I2G3U7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate permease-like protein, mch4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_359779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702857.1">
        <property type="nucleotide sequence ID" value="XM_024844377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3U7"/>
    <dbReference type="GeneID" id="36552077"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359779"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF240">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="40"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="430" mass="45953" checksum="6A8BB4798DDF4D56" modified="2018-02-28" version="1">MPGEVITEKTPSALHRPISEATELADPHGKYPEGGTRAWLVVLGSWCAMVPAMGMLNTIGALHAWTSTHQLAGYSDSSIGWIFGAFSFFLNFGSAQVGPIFDSRGLLPVIAPGSIGLVLAIFFFSASTEYYQIFLSFSVLGGLSSCCLFTPAIAVVGHWFNVRRAYATGIACTAGGLGGVIFPIIILYVGPTLGFPWALRIIGIISFFLCAMACLLMRTRLPPNHAAGMAIDIKALREPNYALTTVAVWLVEFAVFIPYTYIASYGLYAGLGESLAYKLSIFLNVGAIPGRAFPGLLADRLGRFNVMAMTTVICGVLTLVLWYKAGQNHAAIIAYSVLFGFWSGAAISLTPVCISQVCRTEDYGKRNGTTFTLVSFATLTGIPIAGAIQERNGGEYWGLIIFAGALYMASFIAFVVARGVAGGWGLKTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3Z7</accession>
    <name>A0A2I2G3Z7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702904.1">
        <property type="nucleotide sequence ID" value="XM_024849360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3Z7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3Z7"/>
    <dbReference type="GeneID" id="36557059"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437414"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="213" mass="24701" checksum="B40C6268240F0C01" modified="2018-02-28" version="1">MISPSPSLASQCRLDPINLTDPDQFHELHRQRLLCGWDHSPSTLEQWSLKQSEGLKNFFWITIPSPNPNQNPTTSIIRAGHISLDAYSDPPDPELSREDKSILAVQTFFVLPEYQSLRLGSRAMDLIEEIAASEPKCRVIALTALSKRYMYEEGLQGRGLWERIGMEMPRGSIQEWYEKRGYVGWKEEERYEESLKDGGTVWLWEVFMRKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4W0</accession>
    <name>A0A2I2G4W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_427091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703221.1">
        <property type="nucleotide sequence ID" value="XM_024847755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4W0"/>
    <dbReference type="GeneID" id="36555454"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427091"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014172515" evidence="2">
        <location>
            <begin position="30"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="468" mass="51166" checksum="6822AAAE102E4904" modified="2018-02-28" version="1">MRLSRLVTTQVALCLLCLFLLSAFMPTSALPGRGKGIGSHRSSSGSRSSSHSTTSDKKHGLGSLFSSGDKKDDKKDKSTSGKGRKPGSSPGRQGKDDSRGRGSSRGSSRGSNRGSSRGSSHSNPFSDRFDLDNPFSDAHAAGDIFAVEDGPTKDKKPGIGVEFESSGVKFANPQPFKGKKGAETVTIGKAKQKHCQKWTVEKPANEGAIANIGWQYQVTVPMPLGAIHDLFRKARSGENTPLLPGTKMASKGRMIWVNKNFFQANPEGNSPDQITPDAMGFLSLVVSYAKNAETRNPEESPKMLTPIMPRTDFASIYNDVKSDIKGDLYKLVSVLLCYKNDEGDEVEFDSMACDGDAKNPKPKKSMDETTELHLKGENPETERPEEHRVRLKEWMNGLPRGQDILARGDAVIDGQVGGLKSAHEEVYRDSKRLVPLFEFRNLGSVQASGFKRLVEKIEDAVLDYHKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5A7</accession>
    <name>A0A2I2G5A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_437769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703362.1">
        <property type="nucleotide sequence ID" value="XM_024849441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5A7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5A7"/>
    <dbReference type="GeneID" id="36557140"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437769"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.820:FF:000004">
        <property type="entry name" value="Putative RNA polymerase II subunit B1 CTD phosphatase rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="107"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB48060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="326" mass="35556" checksum="9844953216EDA6EF" modified="2018-02-28" version="1">MSSDSMLKTSLPSAHRAAAPKAPAQSTTRRAPSKPKASHQPQAQSQSKSGTDPRHLAIALQHAHRIQAQKDTESLILDRILELATFPPSPSADPASPSPEHAGAFKSALVPFQPADYDNLILERNIEGLCGYALCPREHRKDDFKGTFRVKWGAKGSGPGGHGRDMNIVPREQMEMWCSDACAERAMYIRVQLAEEPVWERRADDTRGKNFVLLEEGRAAQRGKGKAKATVNEVAGQLDSLHMDTEQSGNDTAQDIAQLSVRDDARSRELAMERGDSALSLQAGRVDVQIREKETGSLGNVTAPEMRPGDDKGGSIEGYMPKDQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5H7</accession>
    <name>A0A2I2G5H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_206973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703440.1">
        <property type="nucleotide sequence ID" value="XM_024842790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5H7"/>
    <dbReference type="GeneID" id="36550488"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_206973"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="105" mass="11918" checksum="25FDEAED287018AE" modified="2018-02-28" version="1">MLSFLLSSVVITLVFAFLFFFSTSFLAPGKRIYLEASTITVQETYRTPVAPPSLFIISFLPFHFTFCRCALLQPCGSGFLVYTVRRCTYHLPIWLIQFRSGVCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5S1</accession>
    <name>A0A2I2G5S1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_447989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703533.1">
        <property type="nucleotide sequence ID" value="XM_024850934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5S1"/>
    <dbReference type="GeneID" id="36558633"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447989"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF26">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="507" mass="56327" checksum="20EA6423D7788D7D" modified="2018-02-28" version="1">MGEPKTDNECKFVVSQGGGDTALALFSDPSQPYEPLSTQEAKKLDRKIDWVILPYISVAYAFFYIDKTTLSYAAIFGIQEDLNLHGTQYSWLSSVFYFGFLVWAIPTNLALQRFPVARYLGANIFAWGALLMAQAAARNFIQLAVLRALSGAAEACADPAFLLVTSMWYTRKEQPLKIGLWYTANGFGVALGGLLGYGIGQIKGALPSWKYEFLIIGALCCVWGIVIYVFLPDSPVSAKGFSLSEKRTVVERLREDQTGVENKNFKGYQVLEAFMDYKLYLQFLISLMQSLVNGGISNFGTIIIKGFGFSTLGTTLMQIPYGAIIAISILLCIYLNRILPPNNRCLLLIAFLMPNVAGAFGLRYVPQDNRAGRLICYYLTAPINASFVLLLSLQTANTAGHTKKVINSACLFLGYCVGNIAGPFFYKSEQSPTYILGIWSMIVSHLLEIVVVFVLRFLLARENKKRDKLQGLDGANGLEREVHEQDVDASAFGDLTDRENLNFRYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5S8</accession>
    <name>A0A2I2G5S8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_437900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703536.1">
        <property type="nucleotide sequence ID" value="XM_024849469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5S8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5S8"/>
    <dbReference type="GeneID" id="36557168"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437900"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF27">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="520" mass="56516" checksum="7ECE382EC1B26C8F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5Z5</accession>
    <name>A0A2I2G5Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_465695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703597.1">
        <property type="nucleotide sequence ID" value="XM_024852341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5Z5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5Z5"/>
    <dbReference type="GeneID" id="36560039"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465695"/>
    <dbReference type="OrthoDB" id="5572782at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="65"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120977" checksum="1E7930B2D357FE10" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6D8</accession>
    <name>A0A2I2G6D8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate-sugar epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_438065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703734.1">
        <property type="nucleotide sequence ID" value="XM_024849503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6D8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6D8"/>
    <dbReference type="GeneID" id="36557202"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438065"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="300" mass="33218" checksum="74730F36808F2320" modified="2018-02-28" version="1">MKAIIVTGATGKQGSSVIRNLISKDAPFEVLAVTRDVNSPSAQRLAKLSPKIKLIEGNLDQPVDIFENARTASDHPLWGLFSVQVAIGNTSSEETQGKNLIDEAIRQNVKFLVYSSVDRGGDAVSFTNPTKIPHFVKKHNIEHHLVSAAKDTDTAWFILRPTAFYENLVPGFMGKVFTTAWSMTLKGKPLQLVATSDIGYLAAEAFVNHEKYQGTAVSLAGDELTYEDMARIFKEKTGQSVPGTFRAVCSVLMAAMKDFGVMFRWFRDEGYQADIGDLRAKYPGLKDFGTWLETESEWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6L2</accession>
    <name>A0A2I2G6L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_360968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703816.1">
        <property type="nucleotide sequence ID" value="XM_024844444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6L2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6L2"/>
    <dbReference type="GeneID" id="36552144"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360968"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="103"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="285" mass="32432" checksum="1E0B47486F86B1C9" modified="2018-02-28" version="1">MLSPPSKPEPDDFTNSTTQGSKDVIWYQDALEKVPDIAQQILVNYAGIPEPEVLDHIYRVREKAWNILPYPCIGNFKFLSFPNPLSPVYPEALARIRTGHRFLDLGCCVGQGIRKLVYDGAPAENLIGVDCEGRFVDLGYELFNDRGSLRTEFYVQDVFDENFLSHLRGQVDIIYLGLFLHLFSFDRQKVIMAQVMKLLRKRKGSLVYGRHVGGSEGGVLRNEAFGWDLYYHSPETIRELFEVGGDGEWDVQVQLYACELRGWEKDVQGDGGGQDEQMAFVARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G754</accession>
    <name>A0A2I2G754_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_509444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704002.1">
        <property type="nucleotide sequence ID" value="XM_024854675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G754"/>
    <dbReference type="GeneID" id="36562381"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509444"/>
    <dbReference type="OrthoDB" id="5413793at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="40600" checksum="4B0954863D6EBFA0" modified="2018-02-28" version="1">MEEIWERSLSPERIAYLAQSRIPEIILCNVILLVIATAGLAVRLFVRMRYLTGLNIDDMLCVVSWVFTVVLCVTCMEMTKYGFGKHIGTIQDFTTRGMFLRLDFVTMVAYVLALGSIKVSFCLLYLHIFPGKKFRIACWCVLGILVVETIAEVCVVVFQCQPVHKAWDPTGLVEGVCVDMNLFYYVNFAVKLGTDIALFALPMPKLVQLKMTLGKRIGLVLMFSLGLLVCVTSIIRITYMTQFSEDHTWVLVDTMNWSCVEVAVAIFIACIPSFKSLISYRFPALQRMLGLSSKGGSMGPSRMYGTATRRTYNGLSTGHQNSIKLKPVVGESQAEVETSQNGSQERIVHAGIHVTTSVRVNESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7R3</accession>
    <name>A0A2I2G7R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine synthetase/guanido kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_436596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704229.1">
        <property type="nucleotide sequence ID" value="XM_024849185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7R3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7R3"/>
    <dbReference type="GeneID" id="36556884"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436596"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF2">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="118"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="446" mass="49027" checksum="5E6CF3F897B65C6B" modified="2018-02-28" version="1">MIVSTSDTARWAEFLRQNEGVEFVWLQYITYSATAIVQIMPVNRFTQLIQDGQSLPITKAIYHLLPGDILADGALPSGACHLKPDLSTLYRQRGSNSHRAVVMTSSLNGDGTPLAECARSRLVHLTDLLTQESGYFPLVGFEMEVVFLRRVRQDGKVHYESPNTNHSVFSMTNDDKKALDLVEEVVRALLEAGIALEKFHAESAPGQWEFVLPKDTPVKAVDTLLKARAIISDVAERYDVRATMHPRLFPTSAGNGMHTHISINPTDGQDLVGAEHFFAGIIEHFPAVLAFNLAHEASYSRVQSGTWSGGEYAAWGWENKEMPLRRITTNRFEVKLLDGLANPYLALSGMLAAGIDGLRKKLPLTGGDCRTASGLLTAAEREALGIKTPLPKSLTDSLDALEADDAVSELVSSAIVSTYLGVKRGEVRHFKGLSDEETKDYLISKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7R8</accession>
    <name>A0A2I2G7R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_475247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704217.1">
        <property type="nucleotide sequence ID" value="XM_024853239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7R8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7R8"/>
    <dbReference type="GeneID" id="36560937"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475247"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="334" mass="36550" checksum="D69C4366C0341F19" modified="2018-02-28" version="1">MSTSRLPRIAALRKHQLYLEFSSLKHAAPPGTYVSIAPNDPTLWIGVIFVRSGPYASAVLRFQIRFPSSYPDLPPLVTFATDVFHPLIVPLTTYTFSTNASSEDPVSATDEERLPPGGFSLRHGFPHWFGRDKRNGTGSNASTSASSVRGANVEGEATDAASKDGSIDKEVEPSSPKPQPEGEDDGTADQKNDAAFVPQREDKVQSVPVSILLDYIRSTFDDETVLDSLPLEAAGNPSAWHAWKAHRKDSVNSSLGYNAKRGSPQTRLPGDWHWDGIWAKRVQHEVEASHSESTLFGNTARGTDEMQIRFSRLDDATLASVKNMIVPAVEEAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7S7</accession>
    <name>A0A2I2G7S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_436611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704238.1">
        <property type="nucleotide sequence ID" value="XM_024849187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7S7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7S7"/>
    <dbReference type="GeneID" id="36556886"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436611"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="546" mass="61072" checksum="1A0D04E40266D02F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Y7</accession>
    <name>A0A2I2G7Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_407904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704301.1">
        <property type="nucleotide sequence ID" value="XM_024846704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Y7"/>
    <dbReference type="GeneID" id="36554403"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407904"/>
    <dbReference type="OrthoDB" id="4206571at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="531" mass="60383" checksum="9CAF2C160B575579" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G812</accession>
    <name>A0A2I2G812_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vesicle trafficking protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_407919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704307.1">
        <property type="nucleotide sequence ID" value="XM_024846706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G812"/>
    <dbReference type="STRING" id="1392250.A0A2I2G812"/>
    <dbReference type="GeneID" id="36554405"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407919"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000005">
        <property type="entry name" value="Sec1 family superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="700" mass="79037" checksum="7F3D4E917DC85B66" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G819</accession>
    <name>A0A2I2G819_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_475342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704316.1">
        <property type="nucleotide sequence ID" value="XM_024853248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G819"/>
    <dbReference type="STRING" id="1392250.A0A2I2G819"/>
    <dbReference type="GeneID" id="36560946"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475342"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="139" mass="16036" checksum="06E85BCC78D8319F" modified="2018-02-28" version="1">MPLFRQQQEVLHRRQLRQKHGEHIVNTALITFLQSIKELIPEATKHWSAEQVSFKANFGTGNRRPWRVLVAQDGPELYVSFLEYGLAWEEYITKNRVGSIFPVPAVNLARVWTYGPWTVDDVQGMLGFAKIILAILLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8H4</accession>
    <name>A0A2I2G8H4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_177012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704470.1">
        <property type="nucleotide sequence ID" value="XM_024842639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8H4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8H4"/>
    <dbReference type="GeneID" id="36550337"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_177012"/>
    <dbReference type="OrthoDB" id="5350396at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="696" mass="77405" checksum="138C366AA613F668" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G985</accession>
    <name>A0A2I2G985_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative tyrosyl-DNA phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_456076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704741.1">
        <property type="nucleotide sequence ID" value="XM_024851593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G985"/>
    <dbReference type="STRING" id="1392250.A0A2I2G985"/>
    <dbReference type="GeneID" id="36559292"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456076"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="5">
        <location>
            <begin position="559"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="713" mass="79935" checksum="AFB6B37E105BD33B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAL3</accession>
    <name>A0A2I2GAL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_445338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705200.1">
        <property type="nucleotide sequence ID" value="XM_024850697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAL3"/>
    <dbReference type="GeneID" id="36558396"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445338"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF250">
        <property type="entry name" value="MFS-TYPE TRANSPORTER AFUA_1G00970"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="320" mass="34417" checksum="22FBC03E7D9F9E9B" modified="2018-02-28" version="1">MCFQNAFGVFQEPHGQNILQKHSELDIAWIGSLLTCTLFFSATLAGIFADRLGPTIPLAIGSIGTLIAIFMTSLCDLLYQFLLTQGLLLGISNAFLLCPAMAIVSHLFDRHQSVASGIMISGSSIRGILALQESEKETENTSTERNNKSKDSAALVRNPAFVLLCGSLSLATFGLFSPLFFLSTYAVSQGLSSRLAFYIVSILNRGSLVGRVSMGIFADRYGNFNLCFLIGALSGYYDAIFSLQTPCAVQLASPKSKGALIGIILIAPAIPGLIDTPISGQLIKQSYLALSMFSGAMLLAGSMLVLYIRLRQSRKLFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAQ9</accession>
    <name>A0A2I2GAQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_424397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705271.1">
        <property type="nucleotide sequence ID" value="XM_024847566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAQ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAQ9"/>
    <dbReference type="GeneID" id="36555265"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424397"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF21">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="559" mass="61995" checksum="2691ADA2AB76F101" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAT1</accession>
    <name>A0A2I2GAT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_445392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705280.1">
        <property type="nucleotide sequence ID" value="XM_024850702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAT1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAT1"/>
    <dbReference type="GeneID" id="36558401"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445392"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="300" mass="33833" checksum="46D008FADEFF770C" modified="2018-02-28" version="1">MPTPAYGMLVDVVQKRNGVKCVFSDVEDIDQFSASAIDDILAAFSITIQEAERQGASVKVILMCNPHNPVGKCYDAEVLRAILRFCCERGLHLVVDEIYALSAFGETWSSALSLDEMPTDNLHVLYGISKDWGLNGLRMGFMISYNQHVLTTLKQAVGRFTRFSHLSEDFFISFLSDHSFIDDVYIPTLRQRLIATRTKATKFLVDSKIPYTPSSAGFFLWVDLSSWTDLFPGAESESADLQLARHLVKHGVFLQPNKAFISKKKGCFRFAYSRDEVTFKEGTDRLRRALDELEVADCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB39</accession>
    <name>A0A2I2GB39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_380470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705405.1">
        <property type="nucleotide sequence ID" value="XM_024845528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB39"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB39"/>
    <dbReference type="GeneID" id="36553227"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_380470"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="298" mass="32242" checksum="203C3D17E0C1662E" modified="2018-02-28" version="1">MPHRPPRVWLLTGCSSGFGKLMVPAITARGDAVVATARNIATLADLADQDNVRLLQLDVTASQDVLDETIATAIALFGQIDVLVHNAGYVLSGVWEEVSHSQVLEQFNTNFFGPMNLTRALLPHLRTRRTGTIIFMSSIAGWLGVAAGGPYSASKFALEGAIESLHKETTPLGITTHLIVLGQFRTDILAAGRREVARCVDPVPEYDSLVGALASRQEETHGKQPGDPVVAVERILDVVRREGRFFGTGEVPLRVVLGSDALGIVRGQCLEMLGELDAMEEVVRSTDFEGAKEVQEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCA1</accession>
    <name>A0A2I2GCA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_405645</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705804.1">
        <property type="nucleotide sequence ID" value="XM_024846592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCA1"/>
    <dbReference type="GeneID" id="36554291"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405645"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="401"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="473"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="499"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="522"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB50502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="553" mass="60024" checksum="171F2DC0A59069DC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCQ7</accession>
    <name>A0A2I2GCQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_508810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705965.1">
        <property type="nucleotide sequence ID" value="XM_024854605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCQ7"/>
    <dbReference type="GeneID" id="36562311"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508810"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="503" mass="57452" checksum="1288148815826F8D" modified="2018-02-28" version="1">MKKAIQPAGALPMKAPLIVKPKACVGCRARKVKCDRETPCGNCIRWSVACTYPSPVRTCNRPSKKLFQTEPNPQDAIRTPSPELWDLDISIRICKPPAVSSPSLSRARACWQIFVERVDPVVKVLHRTSAERVLVASVCQPESLRSSEEALVYAIYFASMASMTSDEVREYFHANKDTAFTAHAHLVEQSLARAAFLLDDELSTLQALVLFLTINRLSGRPSVAWKLTGLAKRSEVFRRANLTIFEREMRARLWWNLWYLDHRAVKDLGEEDVSDKDTFPESPLNINDAGLDPGATEAPAPREGWTEVTFSLVRFDIARTRRQLQSQHDIKQSERLIQACETRIHSQYLRHSTNNEPIQWLTQHVAHVLIMEMWFELYSADTVPISSWSQNVQDRLFLLAIDIVDVSARLKAEPHAQQWSWLLTGYQQYRPLAFLLNELCYRQECEAVDHAWKVVEDAVTRWPDQVRASVSAKILAGLRQRARRVQLQITQRQISGDDQIDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCU4</accession>
    <name>A0A2I2GCU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like DNA-binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_508847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706005.1">
        <property type="nucleotide sequence ID" value="XM_024854610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCU4"/>
    <dbReference type="GeneID" id="36562316"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508847"/>
    <dbReference type="OrthoDB" id="2420608at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="61757" checksum="8E4419FF94205C7F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCW1</accession>
    <name>A0A2I2GCW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_445986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706028.1">
        <property type="nucleotide sequence ID" value="XM_024850751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCW1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCW1"/>
    <dbReference type="GeneID" id="36558450"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445986"/>
    <dbReference type="OrthoDB" id="4192742at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="272" mass="30543" checksum="C8572BD6EDE3FFD3" modified="2018-02-28" version="1">MLEANLPIGTKCPVPVPSSIHEPAVAPFPPPIQSVTDLSQRFYRTVDSVEQPRSPAPDSPGQPTPTNPLQETRLGALDTLTLCRNVITTLELTRLRKSRIGLYNWIGFWERLYERPFANSLASRVSTALSKIDMLFRVVSHDLHQLTQRTEDAIISATSEREILHLLERMEVDVGSRRLRRRRKAQAILNKMRTELEMIPVKVGDDLFDDMKRSVFGLDVVCDYHPGDSVAEAHETNWPDHFIGHPVGYTQESAASGAFMPLSSYTANELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDZ3</accession>
    <name>A0A2I2GDZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_474652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706407.1">
        <property type="nucleotide sequence ID" value="XM_024853169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDZ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDZ3"/>
    <dbReference type="GeneID" id="36560867"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474652"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000005">
        <property type="entry name" value="Mitotic spindle checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="281" mass="31072" checksum="90F23B64C4C867F6" modified="2018-02-28" version="1">MTTFSAPVTAPKSMPNNQSALAASFTNFLTVSIHQILFLRSVYPRATFLPVRAYNYPVRQSRHPKVCDYINDASIAVGTEILKGTITAVSIIISSLRTNQPLERYAFDLSGFPRVAAGEINTTFEERKEDSSKPGVPLSERGSAAPTVDLEAQFRACLARLASACARLTPLPRDDEFSFTVCIEVREDALPPAGTTTEEQTWIVAEPDKVHLRSCTAPYSVSKLRNGEPQQQPQQPPPKVSNGRAKTVPVRRVEAGELRLELWVEEARQKFNEPPDSEHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE32</accession>
    <name>A0A2I2GE32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_406734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706422.1">
        <property type="nucleotide sequence ID" value="XM_024846643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE32"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE32"/>
    <dbReference type="GeneID" id="36554342"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406734"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="651"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="717" mass="78609" checksum="8CDBE518F54ADD07" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE47</accession>
    <name>A0A2I2GE47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_436247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706466.1">
        <property type="nucleotide sequence ID" value="XM_024849118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE47"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE47"/>
    <dbReference type="GeneID" id="36556817"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436247"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="207" mass="22152" checksum="C671B6D524A07188" modified="2018-02-28" version="1">MSGQGNQPPGLQPNALLSAVKVGALSGSAGLVYGGISGVLRSQHPVIHSISCGIHWFACGTSFWWIRNGILDLHYQGEATPRQRAYVSALSGGLAGGAVTRLMGGRLVPGAVIFSMLGYLGQGSYNAIDTWQMEHANSPSKPIIQRIADSKWIPLRSLSDDDYRGMLSEKLLSIEAEMSLIDDKIEELERSKADSGFAPMPAEPAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE60</accession>
    <name>A0A2I2GE60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_161037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706444.1">
        <property type="nucleotide sequence ID" value="XM_024842571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE60"/>
    <dbReference type="GeneID" id="36550268"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_161037"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="191" mass="20891" checksum="D31B79A7C4A9CB13" modified="2018-02-28" version="1">MSVIHAYRNKKELQAGISSHLISACRPSKGVVRRGELIIIIKMATESILQTDSQEPDLHARTRGGASSASQWTSTTRSQDSVVSHPLMILCSETAQNIARSKSDRRLGWSPGRSSRLSHSQYSVAQSKSQSGTRPSPFFFCFLGLVPTDYGGVGLLLLVLVLRSSPAFTSTSTFPAQPPLFSFSGDWDWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEG4</accession>
    <name>A0A2I2GEG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706562.1">
        <property type="nucleotide sequence ID" value="XM_024847638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEG4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEG4"/>
    <dbReference type="GeneID" id="36555337"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425508"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="221" mass="23783" checksum="24D81C9264AB881A" modified="2018-02-28" version="1">MPSSSTTNPPTATLTPETLEHDLLTHLASTTALEDLHSNLLCSLQRTGWTEKIRRLSLELLRAGRCDRFDEVVEAVVASAEGRGHALWDAEGNAHAQSQSQSQSQNGSEDGVLDGSGGAGDAAVRNLDVRIPSEVVEQGVRAIKEVLREVVVLEDDGESNVGEGQGQGSNGTEKEREKDKDKEKEKGKHGAEKVKSKSELKNGDTSPVKKTEKKPKPGKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEK3</accession>
    <name>A0A2I2GEK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_353812</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706573.1">
        <property type="nucleotide sequence ID" value="XM_024843996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEK3"/>
    <dbReference type="GeneID" id="36551696"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_353812"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="13"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="390" mass="42544" checksum="C486636187604320" modified="2018-02-28" version="1">MPFKISRTQRLSAVIAISTSFFIAEISVGFYTHSLALIADAFHYLNDLIGFIIALVAVVVANKRTPPKSLTYGWQRAELLGAFFNGVLLFGLGISVFLQSIERFISLQPVENPKLVLIIGSIGLGLNIISVLFLHGHDHGHDHGHDHNHAHSHDHASADEADLHANTHSHALKDQNFRHVDHKHQINASSVSRPGHDLAIMGVLIHVLGDAGNNLGVMAAALVIWLADYDGRYYADPAASMGIALMIFASSIPLIKRAGLILLQSAPGEVDPDDVKHDLERIPGIRAIHELHIWRLNQTKSLASAHILLTDDAKTNFTGLAKTINECFHAYGIHSVTLQPEVWSDRKGFMATPAGTDTEVSDQQARRDSDGSEQSCQLVCGKLCEDLSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEM6</accession>
    <name>A0A2I2GEM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_455532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706635.1">
        <property type="nucleotide sequence ID" value="XM_024851538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEM6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEM6"/>
    <dbReference type="GeneID" id="36559237"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455532"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="52"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="531" mass="58099" checksum="748CBDFBBC889FD5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFA3</accession>
    <name>A0A2I2GFA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_348801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706864.1">
        <property type="nucleotide sequence ID" value="XM_024843698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFA3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFA3"/>
    <dbReference type="GeneID" id="36551398"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348801"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="52"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="787"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1115" mass="126223" checksum="9216EC1716BC30EA" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFJ4</accession>
    <name>A0A2I2GFJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Beta subunit of fatty acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_400979</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706933.1">
        <property type="nucleotide sequence ID" value="XM_024846356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GFJ4"/>
    <dbReference type="GeneID" id="36554055"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400979"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 17" id="KW-0520">NAD</keyword>
    <keyword evidence="6 17" id="KW-0521">NADP</keyword>
    <keyword evidence="7 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="20">
        <location>
            <begin position="1668"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1124"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="18">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="18">
        <location>
            <position position="1812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB51631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2056" mass="226522" checksum="995EFEFE8B55CFBC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFJ7</accession>
    <name>A0A2I2GFJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706957.1">
        <property type="nucleotide sequence ID" value="XM_024852856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFJ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFJ7"/>
    <dbReference type="GeneID" id="36560554"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471584"/>
    <dbReference type="OrthoDB" id="5207033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="623" mass="69195" checksum="4DED8EC040B14220" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGP1</accession>
    <name>A0A2I2GGP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_422954</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707342.1">
        <property type="nucleotide sequence ID" value="XM_024847475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGP1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGP1"/>
    <dbReference type="GeneID" id="36555174"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422954"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03194">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03043">
        <property type="entry name" value="GST_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000045">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="14">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="516"/>
            <end position="518"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="544"/>
            <end position="548"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="770"/>
            <end position="775"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="811"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="814"/>
            <end position="815"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="874"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB52040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="885" mass="97412" checksum="6E0758621156F03D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHG8</accession>
    <name>A0A2I2GHG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707628.1">
        <property type="nucleotide sequence ID" value="XM_024852924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHG8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHG8"/>
    <dbReference type="GeneID" id="36560622"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472229"/>
    <dbReference type="OrthoDB" id="4501801at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="369" mass="41283" checksum="C1C9CF0CC512279B" modified="2018-02-28" version="1">MVIENTPPADQYVEQRPDIEALVMKSLSQTPYRCLSLERLYGGYSNLTFRGILHSPLPDGQTSVIVKHLITHSNADLFDAPECRCASGDKSLEMMHDVLFQHGNVLIRTPAHLYCDTDAKVGVMEDVPNHGTLREYFDLNPGIDKSTALTIGESLGQWLSEFHSRDWSHLDDESAAPFIQNQTTMRESKAIFEFLMDSFHDDSLARESIIKVFSEDDSCQSLIHGDFSGRNSLVQSDSPGKDPNAINITIIDWEMCRFGCSSVDLGSMISSIYIQWRFDGTPSAKFLLNGFIRGYGQVSDHVALRTVALIAVYILLWEKVGGRIPGESRRSQVPGVRDYGRDLLIRAAQGDVKWVSESFLGALLKDRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHI5</accession>
    <name>A0A2I2GHI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_507148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707636.1">
        <property type="nucleotide sequence ID" value="XM_024854453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHI5"/>
    <dbReference type="GeneID" id="36562159"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507148"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="267" mass="30206" checksum="890752EFE3ACDA31" modified="2018-02-28" version="1">MTLLLDKYYGTGSFPTIEGLDNFRDAGGFLTSSKRRVRKGMIFRSANPMSVNESDFSKLDEAYGIKAIFDLRHSTFDESTRRIRMAGPIPVHIVPAVKAFEDGFLHRYFDLLMTNHVDALSDLYMCILGSATDGFRFIFDFIRDNPNTPFLINCELGKDRTGVFIAVILLVLRVSDEDIIEDFGLSEKGIGHLIPSRKEKLRNVLSSNNVSAHPVALDRHFATVRDAMRVFLFRFRAIYGSGEIFLQSIGFTEDDISTVRENLMLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHX5</accession>
    <name>A0A2I2GHX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_489164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707787.1">
        <property type="nucleotide sequence ID" value="XM_024853983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHX5"/>
    <dbReference type="GeneID" id="36561684"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_489164"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF7">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="25940" checksum="149626F91F10F4B2" modified="2018-02-28" version="1">MSTSEPTNGAGIKEPAHLIDVERQSRANTVTAEAPKSLGAGSALALGAFGTTLTTLSLSLMEWRGVTTANVFVGNFFFISAFGLVVTAQWELSVGNGFAYTVFSAFGLFYAGYGAILTPAFGVLESYNGDMTQYNNALGFFMILWTVFVFTFLIGSLPSNLAYIAVFFLVDMGFLTVAASYFAEADGHHASSVALKKAGGGFCFVAGLVGWYIVFHLLLKDALVELPLGDTSRFFAKGVKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ82</accession>
    <name>A0A2I2GJ82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_117646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708235.1">
        <property type="nucleotide sequence ID" value="XM_024842347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ82"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ82"/>
    <dbReference type="GeneID" id="36550042"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_117646"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="29308" checksum="08FD849FC61B7FF1" modified="2018-02-28" version="1">MSLRLLLRFPKARTSLRGTSFACQNCGQIGHRKYDCPEQRNFTANIICRVCGNAGHMARDCPDRQRGSDWRNNGGFGGGRRAIGGGDAVDREMEQLMQELSGGAPGEDGHVPRRIEAGPDQGYDDRDMKPWQRGPPPSDVAPWQQRGRDNRRDDYGPRDHGSAPPWAQGRGGGDYGYGAQGGYGAPPGAAPWQQQAPPPPPGGQPSYGYGGYGGYAPPVPGIGAPPGAPPGLGVPPPPPGMPSMYYGSGGSPPPPPPGEGPPPPVCVPSSEHARFVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK61</accession>
    <name>A0A2I2GK61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_507948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708567.1">
        <property type="nucleotide sequence ID" value="XM_024854518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK61"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK61"/>
    <dbReference type="GeneID" id="36562224"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507948"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25028" checksum="C51A055AE3DD54E3" modified="2018-02-28" version="1">MPEIWLQLATQNGTPKVFEREKHISTPPAAFPLSLNGTDAIPHYPLSDAIVTRAIMDGYIYKVSISGAPFICKLAMQNDIASFERELGLFRKFSSLRRAENLLRVPDLAGTIGFEEGFPGMLLTDICAATCMDDINMGSVDVGERRKWAGQIRATVDILHQNYMVWGDVKADNVLIDAQRNCWLVDFGGGCTEGWVSEELRETKEGGLQGLDNIDRFWDILQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK99</accession>
    <name>A0A2I2GK99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_350650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708579.1">
        <property type="nucleotide sequence ID" value="XM_024843816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK99"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK99"/>
    <dbReference type="GeneID" id="36551516"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350650"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000036">
        <property type="entry name" value="Putative sulfate transporter YPR003C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="617"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="756" mass="82105" checksum="EFD60D972582E5DA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKK6</accession>
    <name>A0A2I2GKK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_129527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708707.1">
        <property type="nucleotide sequence ID" value="XM_024842404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKK6"/>
    <dbReference type="GeneID" id="36550099"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_129527"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="148" mass="16653" checksum="238A5B550ADC525C" modified="2018-02-28" version="1">MQASDGREFDTSSMRLMLSSDASREGKCAKVRWTTRRRVSGGKGGAYIYTWARMVRVLLGGYRKIQHGKPKLGSNAFWQSPSNVSGFSRGAWSLIGRLGYLDFAFHFLSFLFALLFFGSNLKFPCFSFSFSGISPNLPTYYLMHMSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKP5</accession>
    <name>A0A2I2GKP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_463134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708753.1">
        <property type="nucleotide sequence ID" value="XM_024852144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKP5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKP5"/>
    <dbReference type="GeneID" id="36559842"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463134"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB53451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="494" mass="54479" checksum="DC07EDF6CBE23532" modified="2018-02-28" version="1">MEDRKSSLGQLSLIDEKLDQYGLKLADNGRSVIWKSDNPRHPRNWSTARKVYDAFWICYIECRTRHEYGISETLAIFIFVSLHLIGQGLGSIVFPPYSEVCGRKNLYVISTALFGITCAMVAIPSPGGAVIGRLLSGILGAIPTTVVAGSIEDMFNSRYRIWVIAVWTVSWNIGSALGPIYSDYIIEALDWRWIFYVAAIISGAFTIMLLTIRESRPPLVLEREIQKLPPSIRGEGTDALQSFNPDQVPDLTTFVAVFLMRPLRLLATEPIVFLVSILGPIPYAITYLFSQSLPDVYESLGFTTNQAHLPLFAICVGVLFILPARWYNDYRVSKHTRLNRPITPEHQLLGLIIAAPVLAGGMWLFSWTIPPLVPGVHWIVPTIGLVCVGYAGGEFPTVLAGYLSDSYRGYSSSAFAALALVRVLLAATFPLFSPDMFANLGPNVAVTVLAAIATVFCAVPPLLKAFGERIRARSSFAKESLVLYSMTTVDKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL06</accession>
    <name>A0A2I2GL06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_376530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708868.1">
        <property type="nucleotide sequence ID" value="XM_024845374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL06"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL06"/>
    <dbReference type="GeneID" id="36553074"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376530"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="736"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="915"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="55"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="380"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="697"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1018"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB53566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1263" mass="137821" checksum="41EBB761B284163F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL68</accession>
    <name>A0A2I2GL68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_431449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708927.1">
        <property type="nucleotide sequence ID" value="XM_024848039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL68"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL68"/>
    <dbReference type="GeneID" id="36555738"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431449"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB53625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="316" mass="33063" checksum="66E3D8CEE88BD303" modified="2018-02-28" version="1">MSLPKSQYLSDTWKDGLFAKKVVFCTGGAGTICSAQVRGLVHLGADACIVGRNVDKTEKAARDLATARPGAKVIGIGAVDVRKIESLQSAVDRCVKEFGGIDFVIAGAAGNFLASINQLSANAFKSVIDIDVLGSYNTLKTTLPYLVESANKHKVDSKTLDPSPLGTGGRIIFVSATIHYRTMPFQTHVSVAKAGVDALSHSVAIEFGPLGVTSNIIAPGPVASTEGLDRLLPSDAFENYIKSQPLGRVGSIRDIADATVYLFADSGSYVSGQTLVVDGASWRMSAGGAAQGKLNYPDFLLSGDAVPNVKGQKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL81</accession>
    <name>A0A2I2GL81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="2">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_347045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708933.1">
        <property type="nucleotide sequence ID" value="XM_024843605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL81"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL81"/>
    <dbReference type="GeneID" id="36551305"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347045"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="300"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="559" mass="60936" checksum="3A0C5B8457A97037" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM52</accession>
    <name>A0A2I2GM52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_482148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709256.1">
        <property type="nucleotide sequence ID" value="XM_024853875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM52"/>
    <dbReference type="GeneID" id="36561573"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_482148"/>
    <dbReference type="OrthoDB" id="5333917at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="598" mass="67346" checksum="A3BC67AB6E3A9EDF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM95</accession>
    <name>A0A2I2GM95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_372621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709305.1">
        <property type="nucleotide sequence ID" value="XM_024845208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM95"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM95"/>
    <dbReference type="GeneID" id="36552908"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_372621"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="14"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="455" mass="50744" checksum="3670CC73019C05EF" modified="2018-02-28" version="1">MCPYNISPMRKWAIIITICTGTMCVTCASSIYTTTYTQMNAELMISSIISTLGLSFFVLGIAFGPILTSPLSEWYGRRPIYVVSWLLFMIWTAATAVARNIQTIIISRFFTGFAGGTFLSVSGGTAGDVFRCDEIQKPMTFVSASPFIGPCLGPLVGGFIVSHAHWRWCHYSILIWSAIILLSILFLVPETYHPIKLKTKAKLLRKETGNENLTVSVEKPQTTRARALAFSLLRPVQLLTLEPMCLLLDLYSAMLLGLLYLFFQAFPFVFESTYDFNVWKVGLTFLGIISGMILAATSTPLWNRIADQLSGRQTDNRCEKPPEYRLIPAIPGGVMIPVGLLWFGWSLYPDVHWIVPIIGSAIFGCGTLLAFTGIFTFLVDAYPKYAASALASNGLARCSFAAVFPLFGIQMYERLGRHWATTLLAFLTVLMMPLPLLFFKYGQFLRQKSRFALKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMY0</accession>
    <name>A0A2I2GMY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_469700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709539.1">
        <property type="nucleotide sequence ID" value="XM_024852671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMY0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMY0"/>
    <dbReference type="GeneID" id="36560369"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469700"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="283"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB54237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="666" mass="74681" checksum="9FA62096241496F5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN90</accession>
    <name>A0A2I2GN90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Four F5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_469822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709654.1">
        <property type="nucleotide sequence ID" value="XM_024852679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN90"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN90"/>
    <dbReference type="GeneID" id="36560377"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469822"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="62" mass="7060" checksum="0BABA93961BC4128" modified="2018-02-28" version="1">MSRGNQREKARAKNLKAESQVKNKNTMTGSEFQRHKESSAAIMREKQKLADERRAADAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GND1</accession>
    <name>A0A2I2GND1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_431999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709672.1">
        <property type="nucleotide sequence ID" value="XM_024848167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GND1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GND1"/>
    <dbReference type="GeneID" id="36555866"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431999"/>
    <dbReference type="OrthoDB" id="61390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014142030" description="S-adenosyl-L-methionine-dependent methyltransferase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39783" checksum="AA1ED23EDDB76093" modified="2018-02-28" version="1">MNPIQWILSLLKSLLTFIFPPSSDRSIYGLDHAVLNIPAPPPSMWMNMGYWKDETNLPGACRALLDQVLIAAGFLDSTGHPVHTDRQVHLLDVGIGCGDQTMHLVHLLKPDHQAPSYDRRDATAMESRPLFDSYVGITLLPEQADLARQRLEASSRTEESNAMAPTNTGTPIEPTRVDIFCADGADPASWNKELQRAVVSSPVRDSDAPTRTTTWLLALDTLYHFRPSRAPLLRYANTELHASFMAFDLLLSDTATLWQRLLLRGVCMMTGAPFANFLTRTKYEALLVRAGYAIDDIAVTDISEDVFGGLAGFIRQKDARLRRMGMSVGGKFRGAATVFDWWARSGVVRGVVVVARLGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPH1</accession>
    <name>A0A2I2GPH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_398515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710068.1">
        <property type="nucleotide sequence ID" value="XM_024846226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPH1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPH1"/>
    <dbReference type="GeneID" id="36553925"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398515"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="235" mass="26656" checksum="C8807C9F6FF205C7" modified="2018-02-28" version="1">MAIEILPLTKQDIPAAVECVQTAFADDPYFQWLFDDASYDIHRNAASLAAHFHYGLNCNMPMYIAKTTLNAAPDDKHPPHSVVGVSWWYAPQPASAPLPWSIWAQDWLLSMRQLLYNIRFGGRGGLNLSRYRLWKAMQEKTHEKVWTDPRGYYFCNVLAVSAQMRGMGVGKKLVQVVTDRADREGVKCYLESSKGVPNLVIYEKLGFGLVKEIECVDGVDKCKLYCMTRNPSMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPI9</accession>
    <name>A0A2I2GPI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_374167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710091.1">
        <property type="nucleotide sequence ID" value="XM_024845273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPI9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPI9"/>
    <dbReference type="GeneID" id="36552973"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374167"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="594" mass="67139" checksum="42039F517E2BD2A3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPJ1</accession>
    <name>A0A2I2GPJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">pH response protein PalF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_345483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710088.1">
        <property type="nucleotide sequence ID" value="XM_024843515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPJ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPJ1"/>
    <dbReference type="GeneID" id="36551215"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_345483"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="302"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="766" mass="82836" checksum="F8EE69D2B823D395" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ18</accession>
    <name>A0A2I2GQ18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_470403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710278.1">
        <property type="nucleotide sequence ID" value="XM_024852753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ18"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ18"/>
    <dbReference type="GeneID" id="36560451"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470403"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="84" mass="9226" checksum="BD865F78EA657E1B" modified="2018-02-28" version="1">MADDALSIYDEIEIEDMTFDPAIQIYHYPCPCGDRFEIAIDDLRDGEEIAVCPSCSLMIRVIFDPSDLAQDDKNGSAGAVPVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR65</accession>
    <name>A0A2I2GR65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_470794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710677.1">
        <property type="nucleotide sequence ID" value="XM_024852787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR65"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR65"/>
    <dbReference type="GeneID" id="36560485"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470794"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="169" mass="18682" checksum="9A7EBEDA53B030CD" modified="2018-02-28" version="1">MAQQGPSRPLRPIAPRSFPDPPTPGPPPEEGKIKRASMACTECKRRRTKCNAAETAGSPCSECALHGRECIVDEFADKRRKISAKRTEESLKFYRGFVEELLEAIRSGDGPSIESIVNIIRSGASHKEIHSVITQILSQKPREDGDLLDFRKNATPDGKMPDMTPDGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRH6</accession>
    <name>A0A2I2GRH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_461345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710784.1">
        <property type="nucleotide sequence ID" value="XM_024852029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRH6"/>
    <dbReference type="GeneID" id="36559727"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461345"/>
    <dbReference type="OrthoDB" id="4461964at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014142036" evidence="2">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="181" mass="19800" checksum="B685AB7042386279" modified="2018-02-28" version="1">MQLIYIAAALAAITTAHAIDASATPSSSGVAPHRTPDTKPGKPVERTELLTSSVKILLNYDKNCYFELTDIQGCTGKSAPFGTVSKTTGNCENNGAYPLIADICDGQIWIYTHGTDNVETYIPPLGKGEFVTEGMFWFKNSTGHVNDIPYVIGYVMPGCEFYATHFDEEFGLVSWSRSCYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRZ4</accession>
    <name>A0A2I2GRZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_422176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710948.1">
        <property type="nucleotide sequence ID" value="XM_024847421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRZ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRZ4"/>
    <dbReference type="GeneID" id="36555120"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422176"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="227" mass="25929" checksum="0AAF80904FDD82FD" modified="2018-02-28" version="1">MAEQPLSEFLYSGALVQLRSSDSNQPFYVHKALLESKCKVIYSALSRGFLESQEGVYTCTDTTHATLARAVEWMYSGNYPLLSKQELGADARQDSMDTRQEEKANNLSELAEEMKNHPVMTHLQLYIFGEVYLIPDLKQAAHEELTRWCSCIVQGLSPPQALIALLHMAFSNIKPDDRLLHWFAHFSSWRLDVLRQQPLFNDLLLEHPVLGSLMMASVRPASDYPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS71</accession>
    <name>A0A2I2GS71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_471123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711021.1">
        <property type="nucleotide sequence ID" value="XM_024852809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS71"/>
    <dbReference type="GeneID" id="36560507"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471123"/>
    <dbReference type="OrthoDB" id="4093673at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="70" mass="7499" checksum="1FE3269570C5E31D" modified="2018-02-28" version="1">MSRNFFPAIMAIGMGVYTGYYTFNPAFRELQSEKEPSQQAPGAPQSQGQSVAKPSANDSTPAKEDGNGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS73</accession>
    <name>A0A2I2GS73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_322481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711030.1">
        <property type="nucleotide sequence ID" value="XM_024843322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS73"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS73"/>
    <dbReference type="GeneID" id="36551022"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_322481"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="68" mass="7812" checksum="13C85A9C4E0FF993" modified="2018-02-28" version="1" fragment="single">DIWKMTETNQMCIDEAEQSVYNAQSLLCSALAQEYLFMIQQGVEYSYLTTGTALILLRVPDNDPRTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSG5</accession>
    <name>A0A2I2GSG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_433293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711115.1">
        <property type="nucleotide sequence ID" value="XM_024848451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSG5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSG5"/>
    <dbReference type="GeneID" id="36556150"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433293"/>
    <dbReference type="OrthoDB" id="5100247at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="139" mass="15526" checksum="12D8A2B1B1EEC9F4" modified="2018-02-28" version="1">MTPITPVPINETTLPEQLFLDFSIHKILHNDTNGFPITGPWSTEYVASIRTHRYGDAVWARYHIAGDVDSSTGLIEGTNQTVLEMIEEDALGYRAGDPDLYAEALESVYGGRVSWMGIRRWWSCCCGLEGWMVGRCGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSH1</accession>
    <name>A0A2I2GSH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_453064</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711118.1">
        <property type="nucleotide sequence ID" value="XM_024851330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSH1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSH1"/>
    <dbReference type="GeneID" id="36559029"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453064"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF31">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="751" mass="83853" checksum="6C8631C0E23E280D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS32</accession>
    <name>A0A2I2FS32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_451430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698718.1">
        <property type="nucleotide sequence ID" value="XM_024851184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS32"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS32"/>
    <dbReference type="GeneID" id="36558883"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451430"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="226" mass="25952" checksum="AF0E29D61E279C90" modified="2018-02-28" version="1">MSQHSSDALNTSPGLLQIGKELGRSEASSIFEVEIQGTRYAMEVFHDNGDPGFTEKGCDLNRFRCELRAYRNLRLFGVCDRGSVPYYHGYFDRLDPARFQPHLNHFVDDVNNPSAILLEYLEDTEELNCVNYSDDRFRVVIRGLKEIHGALVHHRDIYPKNILIVRGPPERVVWIDFDVAVTFPDKQSVNSQAEGYFDYEVKLAASFGDLLREDQKEGLPPNTKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSG8</accession>
    <name>A0A2I2FSG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_57220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698887.1">
        <property type="nucleotide sequence ID" value="XM_024855277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSG8"/>
    <dbReference type="GeneID" id="36562983"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_57220"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="81" mass="9415" checksum="3DBA5C580F07E560" modified="2018-02-28" version="1">MGNLFYSYQCLFGWLFFFFFFFFSSSVWLVLFLISSVSVRFSAPAFPSPGGMRVVVRVTTLEKYCCIGMLIEIIASVYRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSP0</accession>
    <name>A0A2I2FSP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_513988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698955.1">
        <property type="nucleotide sequence ID" value="XM_024855165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSP0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSP0"/>
    <dbReference type="GeneID" id="36562871"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513988"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="357" mass="39048" checksum="269F4C619A19819E" modified="2018-02-28" version="1">MASATKFSPGYLQESQQGTILGVTVLFIILETLAVTFRGVSKLIGRLNWGWDDALIVLGFILCTVINGCSIADVHHGGVGLHIQRVAKESPEKIPIQGKFMFAFPLIYFAAVVPPKMAIIYLYLSVFTQKPFRVICYVVTGIMIGNWIGTTVASFLSCQPLSYYWTQEGTCFDINSFFRWGGFSNIVTDVIMMVLPMPVVWELHASTRLKLGILITFLLGSLGLIASVIRFVKFYVTDAQKDLTWAGGDLVLWTVVECGGYLIAGCLPTYRPLARFVGRKLHLTSDGSSGGDTTAQHNTSGSSRRQTSKFQRMVNTTDDEEDAIGLVSVSQGNVLAGKHDATGGPGQIVVNHHIDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSP6</accession>
    <name>A0A2I2FSP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_334830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698944.1">
        <property type="nucleotide sequence ID" value="XM_024843376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSP6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSP6"/>
    <dbReference type="GeneID" id="36551076"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_334830"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000005">
        <property type="entry name" value="Nucleoporin complex subunit 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="460" mass="49677" checksum="A81A3673F16924F1" modified="2018-02-28" version="1" fragment="single">MSLFGTGTQPQTGAGANPSPFGAAVTKPSLFGNTGTSGTGLFGSNTTGTGNQQGGGLLGGQSQTPQPSTGGGLFGSTPTQQPSSGGGLFGSTATSQPQQQQTPGTIFGSATTQPKPGGSLFGGLGGGQQQQTSSPFGNLGASNTQQQAPQPSLFGGSLLGGQQQAGQQQQQQQQQQPQAQQQQQQPQLGQTLGQQQQGSSLWSPGRAVTGVHRTVPMQMQIVREKWDANTRSSPFRTYLYNNVGEEAAPFYQPSADDDDTKWEDALRQRPGSGYVPVLVKGFFELGKRAQRQKDFLTMMQTRLHEINNCLTDLLSRHDLKISVKIADCRRKHLVLSKRCLALAAKTQVLRNRGYAMDDAEEELKKKLAQLERSVFDPSLNGRAEEIWARMLAIQEQSKRLQTEIERAGPSAAAQVDDELDENTMKAAKKILDDYHTQIQHLHKEMESVKKDLEEAQKLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSR6</accession>
    <name>A0A2I2FSR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_430700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698964.1">
        <property type="nucleotide sequence ID" value="XM_024847970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSR6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSR6"/>
    <dbReference type="GeneID" id="36555669"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430700"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="505" mass="55537" checksum="D509A485BB4DF7F2" modified="2018-02-28" version="1">MAQSQRSRYLKTGAIIGALLLMILWLSPSRPVTTSLPQEKPSSGVAGATEKCSKPYDSSKPLIQYALMIDAGSQGSRIHVYRFNNCGPTPELEHEEFEQTEKKAGGSGLSSYKEDAEGAAKSLDPLMQVAMRTVPDEYKSCSPVAVKATAGLRMLGPEMSQNILEAVRTRLETAYPFPVVSREKGGVEIMDGSDEGVYAWITTNYLLGKIGGPDETPTAAIFDLGGGSTQIVFQPTFEKSQSGGMPEHLAEGDHKYDLQFGGRHFELYQHSHLGYGLMAARDSIHKSIVESMLAASPDDLRWIKQPIPNPCIGPGMEREIKLTFSSEHRLGKEVTVKMMGPKEGVSSAAQCRGLAEKLLKKDAECKLAPCSFNGVHQPSLEKTFAREDVYIFSYFFDRTKPLGMPDSFTLEELHQLTSTVCGGEAQWGIFEGIADALPQLRDRPEWCLDLNFMLGLLHTGYEMPLSREVKIAKKIKDNELGWCLGASLPLLSQESGWTCRVKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTP7</accession>
    <name>A0A2I2FTP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_368752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699317.1">
        <property type="nucleotide sequence ID" value="XM_024844877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTP7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTP7"/>
    <dbReference type="GeneID" id="36552577"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368752"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="674" mass="78295" checksum="9C1EFBE0AC4B35D4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTZ6</accession>
    <name>A0A2I2FTZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_459596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699386.1">
        <property type="nucleotide sequence ID" value="XM_024851878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTZ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTZ6"/>
    <dbReference type="GeneID" id="36559576"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459596"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="42"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="390" mass="43041" checksum="CFB93348E4181A66" modified="2018-02-28" version="1">MLARLVFRRRPGLRREPVDVSAAFGTNIVAINRGFAKDGAGCHGVQRVGMVASWAHDFPYITERFLNEMDTILGFGLSRLISEGPNSELNKTENSQPAIMATSILILRILEEGFDFDIKSRVDVTLGHSLGEFSALVAGGYLSFSDALKIVRRRAEIMAQCTRHATEQSGETYGMVALICEPEHLDELLSAIHEFLGLSSPGLKDDSSSQMPPIEHVMIANINSRNQIVLSGSLDRIRTLLIQLRQFGGHDPRAVRLNSESPFHSLIMAPAAEYMRSALDDITINFPAYMPCVSNVSGRPFASREQLKLLLSKQCVQTVRWWESIRFLDQEEGVKRWLGLGPGKVGRNLVGKGVGRVATQGGGVWAICDPRELERVMTALEQTEADLSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTZ7</accession>
    <name>A0A2I2FTZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">P170DRAFT_441504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTZ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441504"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="438" mass="48088" checksum="4E6785EDD702C1F5" modified="2018-02-28" version="1">MAGHIEFLSDLNPPSLERTWLTAPHPTLPIVATCSSDKTVRVYSLTNFRLLSTISGGHKRSVRTAAWKPHVQGESVLASGSFDATVGIWRRWDSYGRDEADADGLGPQAESVDGGGRDSDGGNGNDEDDEEWRFAVLLDGHDSEVKSVSWSPSGMLLATCSRDKSIWIWEDLDDGDNNFETVAVMQEHEGDVKCVAWHPVEECLASASYDDTIRLWREDIDDWGQVACIKGHAGTVWYLDWEGVDNVPSFAGEAQSTLVSQWKSQHALSGPRLASCSDDRTVRIWRRHAKEQQTQPPFGGAGMPSIIRPTGTDEVWEEETVLPSKHELSVYAVSWSKRTGLLASVGADGRIVVYQERFVATGLTQTNNTDVPSDDAGLPAPRTEWEVTAVVDGAHGIYEINHVAWAKRADRGREAGQDQEVLITTADDGSIKVWTVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUF5</accession>
    <name>A0A2I2FUF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">magnesium chelatase</fullName>
            <ecNumber evidence="1">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_367747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699556.1">
        <property type="nucleotide sequence ID" value="XM_024844822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUF5"/>
    <dbReference type="GeneID" id="36552522"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367747"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="3">
        <location>
            <begin position="244"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="337" mass="37494" checksum="62C37A5733ABCC1F" modified="2018-02-28" version="1">MDDTAEITRLAVELSDLEVALLLCLAVREHCRIDTTSENIHDVAKELALICANTFNLTYAVLDCSDATSFDDFCSNIIPTDARRRSTTIRSAAEHRVVDVVIAKNFNHVAEDVQVQALELMRSKKLALKDGMLEAPADFLFVPLLVRRSEQDQPKLNAHLNDHFIISHFHDSGDGYIYLEENNDWLSDSQMSASSVVRKSEAPQNKRNPNIDRKTLDKLERASNAVTAGADIVRYQQDIIVFLRLSRAVAGGISVRSNIHFKTLSKLLATLHGVDYLTPSIVALAAKKVFRHRIAVAKPEDDRSLQYGSDLKTISQVLAYATPDTILESVLALETPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUM9</accession>
    <name>A0A2I2FUM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BET3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_368426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699657.1">
        <property type="nucleotide sequence ID" value="XM_024844859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUM9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUM9"/>
    <dbReference type="GeneID" id="36552559"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368426"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="256" mass="28527" checksum="BE0D8575A9EE6442" modified="2018-02-28" version="1" fragment="single">SMAQPPRHAAMLSISNSNSNPATTDKPQPTQQIQTIAQTSPGLRVPSNRKTIYDRHLNRSRNAESSRASFAFLFAEMVTYAQRRVTGIQDLEKRLNEQGYPLGLRLLDLLFYRTMSSSTSSSLSSSSTSASPPNRPLRVLPLLHLIHGPLWRLLFNRPADALEHSVSPDTPNEYMITDNDPLVNTYISVPKEMNQLNCAAFVAGIIEGVCDGCGFEAKVTAHNQPTEMWPSRTIFLLRFGESVMEREKVLERAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUY6</accession>
    <name>A0A2I2FUY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_286549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699755.1">
        <property type="nucleotide sequence ID" value="XM_024843208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUY6"/>
    <dbReference type="GeneID" id="36550907"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_286549"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014112888" evidence="1">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="101" mass="11287" checksum="2CB2858D64722961" modified="2018-02-28" version="1">MATRRNRTFLILVLFSSAACLDSALSSFSASGEIPEIKHQALSLSHCLSGVEQLSVLVIYRQNNDYAIQPHKKVPSSIPSSASPRCVNHLRWCFFFFSVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVH7</accession>
    <name>A0A2I2FVH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase ROK1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent RNA helicase rok1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_393056</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699937.1">
        <property type="nucleotide sequence ID" value="XM_024846006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVH7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVH7"/>
    <dbReference type="GeneID" id="36553705"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393056"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="229"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="484"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="314"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="659"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB44635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="733" mass="80816" checksum="16C3581CD60BCCB2" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVV8</accession>
    <name>A0A2I2FVV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_367164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700070.1">
        <property type="nucleotide sequence ID" value="XM_024844795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVV8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVV8"/>
    <dbReference type="GeneID" id="36552495"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367164"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000319">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="543" mass="60619" checksum="68D61005927C9A26" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVY0</accession>
    <name>A0A2I2FVY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_366188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700101.1">
        <property type="nucleotide sequence ID" value="XM_024844749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVY0"/>
    <dbReference type="GeneID" id="36552449"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366188"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="247" mass="27315" checksum="66C3CE22DE77FED2" modified="2018-02-28" version="1">MTPPKEPRPLTSTVAETETDKIASLRLIADSIAQQHQTAAKAIILHPFWLATIAVCLTLTYRVLLRNQSDWPAVVLTWAGCVMAGLVAVRYLTASYLEHAERTGTWKWLYEGSGHRAGARRVDGVCDHILITKLGDEVIGVLILRPVYTSAGIEPHIRGARHFVRGQEMCFPVGVIRAWTVQRRYRGEGVGRELLQRAVGLCRAQGWGGPIFSQKHANAAQGVARWAFEGGESRARTLLAKMIRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW30</accession>
    <name>A0A2I2FW30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative exo-beta-1,3-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_268874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700155.1">
        <property type="nucleotide sequence ID" value="XM_024843127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW30"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW30"/>
    <dbReference type="GeneID" id="36550826"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_268874"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000043">
        <property type="entry name" value="Exo-beta-1,3-glucanase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="63"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="406"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="773" mass="82558" checksum="5F692B790413CC49" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWH0</accession>
    <name>A0A2I2FWH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_270844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700267.1">
        <property type="nucleotide sequence ID" value="XM_024843137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWH0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWH0"/>
    <dbReference type="GeneID" id="36550836"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_270844"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="291" mass="33000" checksum="76342CFAD8462763" modified="2018-02-28" version="1">MDRICAVTTTSPDGVTFTPSLRDHPPPLVPADRIRQGLNICPHRLNGCFLLELDAATILKVGETVRMGEAEAMILVRNQTSVPVPRVFNAYVIAEIGFIVMEKIHGDELAETLPRAVKKALARELRGYIQQWRQLRGSFFGSVDGGPCQDVIFKHPWENREYDYGPFASREDFNIGMVEALRRSRPNLTLETDEDARFAEELLLSGAGQTETCIFTHGDLDQSNIIVRDGKISGIIDWGVAGYSVPEREYFGLRWPTLDEEWRDLSTSILPPDGYEYWKTVNREMMRYTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWZ0</accession>
    <name>A0A2I2FWZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700429.1">
        <property type="nucleotide sequence ID" value="XM_024850039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWZ0"/>
    <dbReference type="GeneID" id="36557738"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440264"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="82" mass="9181" checksum="AD938434459D19F2" modified="2018-02-28" version="1">MLLVCDRESGGDTEDSMFPTPGAMIIAVGFLIRAEMHVRLWQMRHEWPPSPPCQQPDHIGRSVCQYTSPPDYLLGDSSAYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXA5</accession>
    <name>A0A2I2FXA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700544.1">
        <property type="nucleotide sequence ID" value="XM_024850068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXA5"/>
    <dbReference type="GeneID" id="36557767"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440386"/>
    <dbReference type="OrthoDB" id="4414363at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="469" mass="52993" checksum="70AA8FBFD913602C" modified="2018-02-28" version="1">MEQMEHHLSLCRPPTWPTSHPGFNPNLTPQSHGPSPSTSNPPPAASRPPNPQQPLVSRDAKLVLDNGRSYSGRGLQLDPDQQLRLVKICRRAMTRCDPKAYPKSFWITIATSFEEATGRRYSWQSCRRRMIALVTKRLEFWAVFDECVRRKEYPDCDILDDVADEVDVWLECEKQVPQDCIEKKDEAYQVAEDQIWRKAHAREADKPNPQLTRTPEVPHGAKIQRVVNWVMGLPSLVEMDLLPLHWGESRMDFSRRSRVNADDDRLLLSQSQSQSRSRSPGRDATISYRQRSRSPQADRPAQAINPVMALNRIGQKFHAAAMNLHPPLQRRVNPTGADESSTTQSPLPVAPGVPQFAQPTNKRPRDDDDEANDRPARRLRQTPRSHPSETPVSDPTGLPQNHLKIVENSVDFAFGNFWGGLAPLFGDCDPRQQAQATKPESVMRDMLRDIATAITKAVLKMREADNAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXK9</accession>
    <name>A0A2I2FXK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_440462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700628.1">
        <property type="nucleotide sequence ID" value="XM_024850085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXK9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXK9"/>
    <dbReference type="GeneID" id="36557784"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440462"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="10">
        <location>
            <begin position="80"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="11">
        <location>
            <begin position="389"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB45326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="478" mass="51218" checksum="9DC018525EF98C8A" modified="2018-02-28" version="1">MSAVRPLTRGLHLLGPRSLSQTTSAVANGSSLLPRQLASPRALRSPLAARPSPRVSSVASTGGLRYASSGSSGPVKKTQLYDLHAARGAKMVPFAGYSMPLQYSDLSHVESHKWTRAKASLFDVSHMVQHQLSGPGAQELLMKVTPSSLDKLKDNQSTLSCLLEEATGGIIDDLIITRRSADTFYFVTNAGRRDEDLAFLEAEIDGYRKIHGPDSLKWEILSDRALVALQGPLAAQALQSHIHGDGPETDLSTLYFGNCRVLHLTLPNGSPTAHPLLISRTGYTGEDGFEISIPFTGHPELPAQVTELLLSNPEQVRLAGLAARDSLRLEAGMCLYGNDISTAQTPPAASLGWVVGKDRRDPTSPLSNFNGSSAILPQIASPSKTLSQRRVGFTVEKGSPAREGAIIVDINDESRTQIGVVTSGLPSPSLDGTNIAMGYIKQGMHKKGTEVGILVRNKLRKASVVGMPWIKSKLYHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYA9</accession>
    <name>A0A2I2FYA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_428843</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700926.1">
        <property type="nucleotide sequence ID" value="XM_024847862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYA9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYA9"/>
    <dbReference type="GeneID" id="36555561"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428843"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB45624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18791" checksum="DFAC301CDDFC406F" modified="2018-02-28" version="1">MASTSDMHGSSPVPTLPHPNDNGRTHISSLSSSSSISDAETDRRGRPERPRMASRKPSASILVPRDHPEIEIEEEEFPPDDARAMSPRRNSADLERLGKEARQTLQEQAKALQSSLQALAERIEAVKSDHDKLENENKFLQDYIGGLTRNMTKSEMTRTSTKVRKSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYZ5</accession>
    <name>A0A2I2FYZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Rho guanyl nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_365703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701163.1">
        <property type="nucleotide sequence ID" value="XM_024844719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYZ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYZ5"/>
    <dbReference type="GeneID" id="36552419"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365703"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000504">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000035">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="500"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="876"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1198" mass="135225" checksum="0AD0D46098A06065" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZD3</accession>
    <name>A0A2I2FZD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_512599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701301.1">
        <property type="nucleotide sequence ID" value="XM_024855002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZD3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZD3"/>
    <dbReference type="GeneID" id="36562708"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512599"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38836" checksum="7FCD4D83F816226F" modified="2018-02-28" version="1">MRMSDEDQTGLQQAAGEDYSIEEVDPAGNVTLLIEGPSVARFLVSSKILSIASQVFAGLFHSGFSESMQMENTTCPTISLHEDNPEAMRVIFRALHYKDPEQGILIDAGMLATLAIHCNKYDCAKALQPWVFKWFSGLQNSTTSEEDFGYLLLAAHLFRSAEQFSRLFIKAQTGLSLAFFARWEKMDTMDLLPDGVQRELADRIEKLLDRIHIELQSVEGRLRDNQAGYLMQGLLCVLCGRTHPDTARKCHHCKNNNLIDKYCTSDSRIAEYFAALRKSRLWPSLEAFQNSSADEIASFISQIRRALRHSCHTISCPLESELDRLTKSANEIIGEVRGIDLNPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZR7</accession>
    <name>A0A2I2FZR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-dihydroxybenzoate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_429266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701425.1">
        <property type="nucleotide sequence ID" value="XM_024847882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZR7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZR7"/>
    <dbReference type="GeneID" id="36555581"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429266"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000043">
        <property type="entry name" value="Amidohydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="64"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="338" mass="38575" checksum="1F1768CF894205A6" modified="2018-02-28" version="1">MLGKIALEEAFALPRFEEKTRWWAGLFSTDVETHVKEITDINKIRIQHADKHGVGYQILSYTAPGVQDIWDPVEAQALAVEINDYIAEQVQANPTRFGAFATLSMHNPQEAASELCRCVEKYGFKGALVNDTQRAGPDGDDLIFYDNASWDIFWQTCADLDVPFYLHPRNPTGTIYEKLWADRKWLVGPPLSFAHGVSLHVLGMVTNGVFDRHPKLQVIMGHLGEHVPFDMWRINHWFEDRKKLLGLAETCKKTIREYFAENIWITTSGHFSTTTLNFCMAEVGADRILFSIDYPFETFGDACEWFDHAELNGTDRLKIGRENAKRLFKLGPYHDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0C0</accession>
    <name>A0A2I2G0C0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_512840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701621.1">
        <property type="nucleotide sequence ID" value="XM_024855031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0C0"/>
    <dbReference type="GeneID" id="36562737"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512840"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="323" mass="35085" checksum="3DB094454A224557" modified="2018-02-28" version="1">MKSTIPSRIWETKRVLITKLYEEEEWPLKQVIRALQSKDFHPSETQLRSRLKKWHVTKPSRKKWSTNKRPTSDDSSTLRSPETGHHHPGRGVGTSQSHLPDTTSLSPLASQGLSTPACAEAPCFPPASSFIQPLAYTQSIPESGIGFETVRRDPSGCRLPSQPARFPSGTQHEPGGSVYRWPACFDPLGLGTAASAPATSTDPLLSSLRHPPIVPSMGYPKASIESNPTAEARPTVPRIGVQRSKSSRGTQPGRHIVSGDGEENEGLGIYGAETNFLLEGYPAWIGPYDVYSVGSPSPSKVSYLQPPPLWPVGDTAVSDGNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0I2</accession>
    <name>A0A2I2G0I2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_477270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701692.1">
        <property type="nucleotide sequence ID" value="XM_024853435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0I2"/>
    <dbReference type="GeneID" id="36561133"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477270"/>
    <dbReference type="OrthoDB" id="4291851at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014146144" evidence="1">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="96" mass="10274" checksum="D0ACA37736CE563A" modified="2018-02-28" version="1">MYALKQISFLALALFSVGSVAKMTTIGLETPEGSKPIQVPFDECHLVDEEEVFTVATTTFCRFFVGTVCNGRQTLLGPGDHSSADPVPIGSVYCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0K5</accession>
    <name>A0A2I2G0K5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_477288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701709.1">
        <property type="nucleotide sequence ID" value="XM_024853438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0K5"/>
    <dbReference type="GeneID" id="36561136"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477288"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="333" mass="37580" checksum="E1EEF7F98E5D7ED0" modified="2018-02-28" version="1">MVLTLRGSVNVAQLTSMKLYFYLLEKMICLQASIVDGLQINIITEKALERFPDFSRELQISDSEMRVPKSNGGYYLAKDQIELNFSTEDMKFSNTETFYTYKGGDGDLDPSIDVIIGRDSEAVRYFIGDQNAKQQDPLAQHATAAEKMPAKGASTGEVSDEHISHENFTRLACVSVQDKVFPSKIGFYTQAGADVITKAACERMQLEIESCSDVRFRLQSYFSHSEVSATRVVRELKFHLNGDRKIYTGDFFVLDLDLSNNVDIILCSKSLAKNEIVVFSHKLKRNKRSLSVPQRPKDCEKGIPPVAEWERGKPTLSQRANHGGTHRAGRYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0W5</accession>
    <name>A0A2I2G0W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_217377</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701836.1">
        <property type="nucleotide sequence ID" value="XM_024842842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0W5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0W5"/>
    <dbReference type="GeneID" id="36550541"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_217377"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF346">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="895"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="922"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="965"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1040"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1098"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1132"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB46534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1155" mass="125302" checksum="D9F2754561C14BBC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1A8</accession>
    <name>A0A2I2G1A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_438373</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701967.1">
        <property type="nucleotide sequence ID" value="XM_024849588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1A8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1A8"/>
    <dbReference type="GeneID" id="36557287"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438373"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="94" mass="11045" checksum="93EFFFE432561419" modified="2018-02-28" version="1">MATEKKDKLEPQIKSVDMTEDMQQEAVEVAIEAMDKYHIEKDIAQYIKREFDSRKGATWHCVVGRNFGSFVTHETKHFIYFYLGHCAILLFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1B5</accession>
    <name>A0A2I2G1B5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_511363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701970.1">
        <property type="nucleotide sequence ID" value="XM_024854882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1B5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1B5"/>
    <dbReference type="GeneID" id="36562588"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511363"/>
    <dbReference type="OrthoDB" id="2562973at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="576" mass="63745" checksum="9A1B5E9D1E4A108D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1F8</accession>
    <name>A0A2I2G1F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_219725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702010.1">
        <property type="nucleotide sequence ID" value="XM_024842855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1F8"/>
    <dbReference type="GeneID" id="36550554"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_219725"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="80" mass="8892" checksum="788E159C021773CF" modified="2018-02-28" version="1">MYLALGGRSTVTLGTRCLLVGVASIATSRQDDVDEIQCGTFTQRNRVVSGKHSRSPHKKKKKKKKKNEWRPDAAPLLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1V5</accession>
    <name>A0A2I2G1V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_363645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702162.1">
        <property type="nucleotide sequence ID" value="XM_024844591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1V5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1V5"/>
    <dbReference type="GeneID" id="36552291"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363645"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="353" mass="39507" checksum="88A813F2BEDF9FE3" modified="2018-02-28" version="1">MASAGGLTRRRGGGRATGGDENDDSRVSSPVSRNGSALDNRVPETSFTSTENGHKIAFDPRDISETEERNKQPKLTLMEEVLLLGLKDKQGYLSFWNENISYALRGCIVIELALRGRISMQKDSSRRRFPLADRVIEVIDDTLTGEVLLDEALKMMKSSEKMSVNSWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKDDIHRRVRNICSNRTVILPPNTWLPEDIEFRYLRTISMVCAAYAANVLENALVTMSHEARERAFAQVDELLAEYSQWPFARRPGGSQAIGANLAQAINDEVNSGKDKELQLEIVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G217</accession>
    <name>A0A2I2G217_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_438618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702220.1">
        <property type="nucleotide sequence ID" value="XM_024849642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G217"/>
    <dbReference type="STRING" id="1392250.A0A2I2G217"/>
    <dbReference type="GeneID" id="36557341"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438618"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="443" mass="50182" checksum="3975BC4488607573" modified="2018-02-28" version="1">MDSPAVPAPLDPQEQPILDRLLHTRDALLLIKQDKSSYIKSRDVLPLYEEVIGEVEKLNAVRKEGDRRLSHNRLDYVLDDCFQLISLLFLTVGRNNEAPAVYSLATTVQRLLDHLEEAGFYSSKDLDSITKTLANMNETIERCRDAYSPALLTLLESRLEKCRRLLNKLQSGLAALSPELAPTHETLVSILRSTSAVNTRSKFSATEVNGLRNQLKKIESTMKDGNFVGADGSLLTGQDGLKALMERCWRWTEIVLEREGKIDERFQEQYERLLDIRNQLDRLSVTQAWSLRETDLFGYQRKLDRIDEARTNGNFVDAVGQPADIHAQRTLLYLIRRSYGYIYALLISSEPVSEALLPVYNQLQTLRRCLLEVKESGGVSNSRELYPYSMKLNSIDNMRIDGKFYVGSDIPEGQGSVNALLAECYDIVWELRAAVVDEDEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2D6</accession>
    <name>A0A2I2G2D6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative beta-1,6-glucan boisynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_412514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702327.1">
        <property type="nucleotide sequence ID" value="XM_024846935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2D6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2D6"/>
    <dbReference type="GeneID" id="36554634"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_412514"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008659">
        <property type="entry name" value="Kre9/Knh1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05390">
        <property type="entry name" value="Kre9_KNH1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014167049" evidence="3">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1 C-terminal" evidence="4">
        <location>
            <begin position="156"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="247" mass="26668" checksum="56812417C2249A9A" modified="2018-02-28" version="1">MNVSCLLFLACAFLQTALADIEFTDPVTGSVLEAGHVVTAHWKDSGTSPRISDLVQYDLYLCALWDAPGADDETAFLIQGGVFARGNSVSFEINPDVSGDAPEAYYLKMVASGPDVLVVRHSGWFTLTGMAGHDSVDFMSDDRAHQDLRKRQAVGAYTIPYQLQSGPTKYAPMAKKPRSTIPARSSPTPQFPTSAYSVATAYLPAPTVKATLSAARTYSVVSVENTASPAPHPDDAEMEKFLARWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2E8</accession>
    <name>A0A2I2G2E8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADPH--cytochrome P450 reductase</fullName>
            <ecNumber evidence="20">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P170DRAFT_466399</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702356.1">
        <property type="nucleotide sequence ID" value="XM_024852413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2E8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2E8"/>
    <dbReference type="GeneID" id="36560111"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466399"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000017">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000036">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000032">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF108">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 20" id="KW-0521">NADP</keyword>
    <keyword evidence="13 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="21">
        <location>
            <begin position="96"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="294"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB47054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="721" mass="79870" checksum="1E797605B43F68BE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G393</accession>
    <name>A0A2I2G393_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_478193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702644.1">
        <property type="nucleotide sequence ID" value="XM_024853534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G393"/>
    <dbReference type="GeneID" id="36561232"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478193"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="144" mass="16898" checksum="F0E19B63C264B927" modified="2018-02-28" version="1">MSERITLLWLTIEVHVRCRTKIQLYDYFLQALEQDEFTVTDDLFELTDRNIVDVAHEHILEILGRDDIPFAQQWDTIRQTAKDKVQQLKEIEERRLGPPPYEPSQSPPPYQPSQSPPPYQPSQSPPPYQPSQSPPPYQRRTEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3H3</accession>
    <name>A0A2I2G3H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_439090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702727.1">
        <property type="nucleotide sequence ID" value="XM_024849758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3H3"/>
    <dbReference type="GeneID" id="36557457"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439090"/>
    <dbReference type="OrthoDB" id="4427833at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB47425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="156" mass="17459" checksum="5E1228E5C27695A8" modified="2018-02-28" version="1">MTDHPMQTAESRGSCNILRSRSLESTCVFRRFSQWLWSSWTAVPSESQSTVQNAARRGNDPNYSLAPGKPAGDTTPRYIPNDEPPQEQIAERENYPCKACQAWGVTCDRQRPRCAHCLDQQILCFYVAPLPKTIRRPKQPASSHPTRPRASVGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3L8</accession>
    <name>A0A2I2G3L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_510309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702777.1">
        <property type="nucleotide sequence ID" value="XM_024854766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3L8"/>
    <dbReference type="GeneID" id="36562472"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510309"/>
    <dbReference type="OrthoDB" id="3780330at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014178214" evidence="2">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="409" mass="43650" checksum="D3EEFB5A036C9CCD" modified="2018-02-28" version="1">MIPKICYLLFYFFLSLVVGSPVALQARAPPSLGITKQTIQSGGRNPWTAFGSVLTLEENAKISKEQLAGIVKAAYGEMSTLEPDVAKRPNVMTALQVGNEVILSSNMKGGGGVYVYNMQEQPLENKKNPNEDVVENGYGAFTDVLEKNAREVKDVLDSLRETSRNLQNSQQSSTQQSNGKQPAQPSNNGQGNRNGQKGSARKSPNDLSQELKGSRQTSFQHKNDANCGEVMASIRYNAVHKNGKLKNLTPKPMVVAWSESEKNGKMVGSIRAPCEKGQTLDGNSDLCGLSWGCGAFTGAQGMNWDVVATNTKPTEVTDAKFPKFQSKAVDLPAPTIKKKTNNNNGGGRNTNSNQPAAAPNQPAPKQPAPKQQPAQQPAPKADPKPAGAPASAPKTDPKKPGKKGGGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3W0</accession>
    <name>A0A2I2G3W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_476243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702860.1">
        <property type="nucleotide sequence ID" value="XM_024853328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3W0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3W0"/>
    <dbReference type="GeneID" id="36561026"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476243"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="534" mass="58734" checksum="000A917054281A8E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3W4</accession>
    <name>A0A2I2G3W4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702863.1">
        <property type="nucleotide sequence ID" value="XM_024849355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3W4"/>
    <dbReference type="GeneID" id="36557054"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437393"/>
    <dbReference type="OrthoDB" id="4509525at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="81" mass="8115" checksum="3C6E0526DDDCEE58" modified="2018-02-28" version="1">MPSHHHMTQSDASRIQSSQAKGGGDMSSGGFAARAQSAGDRAATSTSQYSSQGSASQTSSYNPSSAGRWTSGSGSTGQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G414</accession>
    <name>A0A2I2G414_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_465243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702910.1">
        <property type="nucleotide sequence ID" value="XM_024852307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G414"/>
    <dbReference type="STRING" id="1392250.A0A2I2G414"/>
    <dbReference type="GeneID" id="36560005"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465243"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="493" mass="53913" checksum="48B4A54F7288DB2A" modified="2018-02-28" version="1">MSKRSADVSDEQSAALKAGDRPVTQAPPDEVGEFEDEFEDEFESEDEILEAGVDGRPDAELEEEQKEAMEVDQQTFIPGRTKLAPGEVLSPDPSTYDMLHTLSTPWPCLSFDIVRDSLGDNRKTYPGTVYAVAGTQADGGRAKENELMVLKMSGLSKMEKENETDSESDDDDDDVGEPILESKSIPLGSTTNRIRAHQTPSQSGDYNKPPQTLTATMLENSQVVIHDVTQHLASFDVPGTVIPPSASKPLSTLRMHKSEGYALDWSPLQPLGKLLTGDNDGLIYATTRTEGGGWVTDTRPFTGHTSSIEELQWSPNERNVFASASSDGSVKVWDVRSKSRKPAVDVQVSNTDVNVMTWSNQTFHLLATGADDGQWAVWDLRHWKPSAPSTQTTASPVAAFDFHREPVTSIEWHPTDDSVVAVGSADNTVTLWDLAVELDEEESREAGMSEVPPQLLFVHYTESVKEVHWQAQMPGTVMATGGSGFGIFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4E9</accession>
    <name>A0A2I2G4E9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glucose oxidase</fullName>
            <ecNumber evidence="12">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_447667</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703062.1">
        <property type="nucleotide sequence ID" value="XM_024850901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4E9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4E9"/>
    <dbReference type="GeneID" id="36558600"/>
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    <dbReference type="OrthoDB" id="269227at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014158885" description="glucose oxidase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="288"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB47760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="632" mass="69808" checksum="CB4AE04540D07B29" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4N5</accession>
    <name>A0A2I2G4N5_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_198249</name>
    </gene>
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        <name type="scientific">Aspergillus steynii IBT 23096</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_198249"/>
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            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="92" mass="11335" checksum="77263D810CB5207C" modified="2018-02-28" version="1">MGYHLKIGRKSEDMGEEVHKDQTSRNRIQKQKKERLKSYNEQMWAKWVKHGHRRFCTRNAEQEKRMRVLYSRLLESLLCPCKDDFKHRKCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5C1</accession>
    <name>A0A2I2G5C1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_204580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="GeneID" id="36550476"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_204580"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="94"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="181" mass="21229" checksum="C10AC2E756FBCDFD" modified="2018-02-28" version="1">MRWTKMLESREEEKKKRGCKEGKEKGRGRERERERESRAFPEPQRKKGKRKRKRKSNEADITTSPHVDLRPAWSSSTGDARSHNRSDVWTSQRRQKPIWMGGCRGRCSVQAPKVPRSLPISSPNLLIAINQRCLMRCRWRWTSHSHSTNSINFQAHQANHRRRMADDARRVAIIPADPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6I1</accession>
    <name>A0A2I2G6I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_427571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703789.1">
        <property type="nucleotide sequence ID" value="XM_024847782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6I1"/>
    <dbReference type="GeneID" id="36555481"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427571"/>
    <dbReference type="OrthoDB" id="4476188at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014194957" evidence="1">
        <location>
            <begin position="21"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="326"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="393" mass="43474" checksum="4F9CC71F8D427CBB" modified="2018-02-28" version="1">MHITFFNLLCILIYGRFAICAESSAPQNYDKICPSQDNTVKALDGDYRILYHCDAYPTTYDAQGTFQVQDPDSCAQICQRKSGCRGAIWSAAQQTCWTSEDQSNRLIPYQGLLYLKHVEGTPEQQPKEPMCDSAVAACTQQKDICEKQSAITQAEVQACKEQKDVSDKQAEAFSASLIACEAQKEIADRNSEVNKARLTACETQKDVCDKQSEANAASIAACNAQKDILEKRSQATTTQLTSCGEQNGMLEKRLAANSAQLTSCQTQNSALNARAETNSAQLTACESQKATWEKKSKDDAARVTTCEASREALKTECAKNAEGKIKPNLYTIMARHCNKFVDLKDGQTADGTKIQLWEKSPTLNQRYFIYHVGNEEYLLRNQRTGTYVTASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6K9</accession>
    <name>A0A2I2G6K9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_465832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703813.1">
        <property type="nucleotide sequence ID" value="XM_024852360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6K9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6K9"/>
    <dbReference type="GeneID" id="36560058"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465832"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="339" mass="37534" checksum="06CEB79DFD260A1D" modified="2018-02-28" version="1">MAQEYGKDKPEGFSNRIEKVAIVGAGGQVGKHITEHLLKTGKHTVTAITRPNSTSQLPEGVQVARVDYSGDDDSALVDALRGQQVLIITMAVMAPRDTTVKLIRAAAKAKVPYVQPNWFGHDSQNPKLLDESMLSHRSACAEIERLGVSSYLLLNCNFWYEFSLGGGPDRYGFDFHKRSLILFDDGNTVINTSTWPQCGRALASLLSLKELPDDEADKSPTLSRFRNGPVYVSSFRVSQRDMFESVKRVTGTTDADWTITHESSEERWKEGQAVVKQGDFLGGFAKQLYSRMFFPNGDGDFESKRGLHNGLLGLPVEDLDEYTALGVRMGENNEVVVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6R4</accession>
    <name>A0A2I2G6R4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CBD9-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_497997</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703861.1">
        <property type="nucleotide sequence ID" value="XM_024854123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6R4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6R4"/>
    <dbReference type="GeneID" id="36561828"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_497997"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014143399" description="CBD9-like protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="206"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="63527" checksum="18ED779432F02B7E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7E4</accession>
    <name>A0A2I2G7E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_425812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704104.1">
        <property type="nucleotide sequence ID" value="XM_024847674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="36555373"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425812"/>
    <dbReference type="OrthoDB" id="2913095at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="3">
        <location>
            <begin position="117"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="370"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1465" mass="166190" checksum="697386037BEE178B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7K7</accession>
    <name>A0A2I2G7K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sterol delta 5,6-desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_358857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704161.1">
        <property type="nucleotide sequence ID" value="XM_024844320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7K7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7K7"/>
    <dbReference type="GeneID" id="36552020"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358857"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="166"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="341" mass="40224" checksum="C1A9B5689FD69CB9" modified="2018-02-28" version="1">MDVLLDILDTWVLDRFYATVFPRPAAKFIDHPFPANGSEWLNLNQNINRYVEVTPSQWAVQSSWPRDNILRQGLSLFLVAWGFGTVLYFISATISFYVVYDKRAMKHPKFLRNQIRLEIKQAMQSMPGMAVLTALCFVAEVRGYTKLYDFPEEGPFALYTYLQYPLFIAFTDCGIYFIHRGLHHPWIYRHLHKAHHKWIVSTPFASYAFHPVDGFSQSFPYHLYPFLFPLQKIAYLALFVFVTIWTVMIHDGEYALNSPMVNGSACHTIHHYYFNYNYGQFTTLWDRLGGSYRKPNPELFDREERLKKDEIQKQVQEMERLVKEVEGEDDRCYESEAKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7V3</accession>
    <name>A0A2I2G7V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_383415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704256.1">
        <property type="nucleotide sequence ID" value="XM_024845639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7V3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7V3"/>
    <dbReference type="GeneID" id="36553338"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383415"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="106" mass="11389" checksum="267542008F6A6343" modified="2018-02-28" version="1" fragment="single">MANKSKKTGDTINSRLALVMKSGKVTLGYKSTIKTLRTGKAKLVIIAANTPPLRKSELEYYAMLAKAPVHHFSGNNIELGTACGKLFRCSTMSVLDAGDSDILTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7W1</accession>
    <name>A0A2I2G7W1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_407825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704266.1">
        <property type="nucleotide sequence ID" value="XM_024846700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7W1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7W1"/>
    <dbReference type="GeneID" id="36554399"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407825"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000394">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000135">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="10">
        <location>
            <begin position="202"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB48964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="47341" checksum="1A39436A1A3C7716" modified="2018-02-28" version="1">MADPSIEIDVDLEVQEILLAASQHDIPKLRRLIRSHTAVPNAANVKDTETGYSPLHAAIAACESDDEPVNGESNGVHANGTQPSQEKSVVESGVNTVKFLLQEGAIWNDLDLNNETPGCIAKRIGQNELYEMIVDAGVRAELLLNRLDGYEELSEMDEDEEEEKGEDAEKAQEEQATTEQTTTDDQTAPELVDITQVEGAGPDVSQSRYLDSNLTFQQDRLLDQDQNGVMMAWESDIMAKSAKKILPTPGLRVLNVGHGMGIVDGFLQEQSPAAHHIIEAHPDVVAEMKRKGWDQKPGVKIHEGRWQDILPALVGEGEQFDAIYYDTFAESYGDFREFFSEQVIGLLDQEGKWSFFNGMGADRQISYDVYQKVVEMDLFEAGFDIDWEEIAVPTLEEEWNGVRRPYWRIEKYRLPLCRYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Y6</accession>
    <name>A0A2I2G7Y6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_171816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704286.1">
        <property type="nucleotide sequence ID" value="XM_024842620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Y6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7Y6"/>
    <dbReference type="GeneID" id="36550318"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_171816"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="94" mass="10173" checksum="B88704F2AE8F9E12" modified="2018-02-28" version="1">MQALTKRKPSADFEGVIAPDRNVPGVWDAVLTDVDSIAHVAGDVSFGPDPTKVIPPSVEALRRLLEVTTKEPSPKRFVFTSSDQAASNRLDLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Y8</accession>
    <name>A0A2I2G7Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptic vesicle transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_356432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704287.1">
        <property type="nucleotide sequence ID" value="XM_024844149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Y8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7Y8"/>
    <dbReference type="GeneID" id="36551849"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356432"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="85"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="517" mass="57020" checksum="148B3AD83AFB52AC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8K4</accession>
    <name>A0A2I2G8K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_408266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704512.1">
        <property type="nucleotide sequence ID" value="XM_024846718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8K4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8K4"/>
    <dbReference type="GeneID" id="36554417"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408266"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="111"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="572" mass="63444" checksum="06E5387FABFF4292" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8Q0</accession>
    <name>A0A2I2G8Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_446968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704564.1">
        <property type="nucleotide sequence ID" value="XM_024850841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8Q0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8Q0"/>
    <dbReference type="GeneID" id="36558540"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446968"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014199127" description="3-phytase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="753"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="934" mass="104170" checksum="2BC5474B908E02BE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8S7</accession>
    <name>A0A2I2G8S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synaptobrevin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_495067</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704588.1">
        <property type="nucleotide sequence ID" value="XM_024854080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8S7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8S7"/>
    <dbReference type="GeneID" id="36561785"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_495067"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000063">
        <property type="entry name" value="Synaptobrevin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="227" mass="25747" checksum="DF55FDBD658200EC" modified="2018-02-28" version="1">MSEQPYDPYIPSGSNGAPASAAQNGDPRTREIDKKIQETVDTMRSNIFKVSERGERLDSLQDKTDNLATSAQGFRRGANRVRKQMWWKDMKMRVCLVICVIILLVVIIVPVVGNQQSVLRFHGGRHPKHVEQATPRHAVDAELRGRHDEEWTGKTPRVNEPETFPLANRSDNEGPNALRNDIWELYRGRDPSGEGWANGYSSMRGARQTINRSKRDLIIPEFLECGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G917</accession>
    <name>A0A2I2G917_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_447038</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704673.1">
        <property type="nucleotide sequence ID" value="XM_024850847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G917"/>
    <dbReference type="STRING" id="1392250.A0A2I2G917"/>
    <dbReference type="GeneID" id="36558546"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447038"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="82"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB49371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="390" mass="42554" checksum="4AF3A3193EA5011D" modified="2018-02-28" version="1">MSLPLPRSLPRTLLKRSYGTVQQAPSAASLNSRIPIALQEATGATVPRTNWTREDVQQIYQTPLNQLTYAAAAVHRRFHDPSAIQMCTLMNIKTGGCSEDCSYCAQSSRYDTGLKATKMSPVDEVLKAARNAKANGSTRFCMGAAWRDMRGRKTSLKNVKQMVSGVREMGMEVCVTLGMIDENQAKELKDAGLTAYNHNLDTSREFYPTIITTRSYDERLKTLSHVRDAGINVCSGGILGLGEADTDRIGLIHTVSSLPSHPESFPVNALVPIPGTPLGDRKMIPFDKLLRTIATARIVLPATIVRLAAGRIALTEEQQVACFNAGANAVFTGEKMLTTDCNGWDEDRVMFEKWGYYPMRSFEKGDEVSQPAVESTPESVSPAPAAATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9M5</accession>
    <name>A0A2I2G9M5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704876.1">
        <property type="nucleotide sequence ID" value="XM_024849298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9M5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9M5"/>
    <dbReference type="GeneID" id="36556997"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437151"/>
    <dbReference type="OrthoDB" id="5343576at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="508" mass="55142" checksum="149A19AA02D0A582" modified="2018-02-28" version="1">MSPAPAVAEMQPDHSLQTLARAFEALLLTTQQLSCKEKSLQLRLKYANNEYTKLADRLPNGPDTHTKIVSEKILGRYTEFDHTQKEPLSPEAVVKTLAESGNVGDQALSAITEGLACYQTIVPSQEGGLLPDLNQCVVATRAGAPRPLEKDFTTRGMKGSLRCPFAKSRAKPSENGVSNGIEDRSNVPNDACGHEDLDPIKAELKDKHSVQTPSARSSTTQCQVSRCPIRFLDQHSPEEVADYVERHKHEIPRSHAICVQRYQKDSSSMRQLDAKYGNLISMIRGLSVKHQAFLPPNGQSDGPTSNSSAERVEKWAEDVGLKSEMQPSIKEEEEEEEERKGHFDRPLREVRVGESPSRPWGIPVPAPFPAVPAGPHSPAAPVPASLSHASPKSSDHADADVSSIAPLQGPSHDVADAPPKTGRCPFGHGAPPADNMAPETETVRNPDPMNDTPEDTTGQDYEAPPEFQRPSSNPPAQVVFNGPVFFGFSPDQTAAFLQQLSSLGHNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA28</accession>
    <name>A0A2I2GA28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705015.1">
        <property type="nucleotide sequence ID" value="XM_024849320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA28"/>
    <dbReference type="GeneID" id="36557019"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437251"/>
    <dbReference type="OrthoDB" id="4444672at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190813" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="120" mass="13035" checksum="8F5A18AA5AF5E52E" modified="2018-02-28" version="1">MKISLALSALALLACPAAAVDLNPTKDCSEPWSAWNWECKRSASNCCHYAAEKANTTCPMSRSRHYFLLGRCSKLFEGSASPYNKTDCVSASLSGIALIMGDRGLDFPVHCTIDDIKDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAZ1</accession>
    <name>A0A2I2GAZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_355547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705351.1">
        <property type="nucleotide sequence ID" value="XM_024844095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAZ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAZ1"/>
    <dbReference type="GeneID" id="36551795"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355547"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008823">
        <property type="entry name" value="PRK11873.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="286" mass="30967" checksum="2E55AE0ADC440BBF" modified="2018-02-28" version="1">MNPKETYRCVQDRYAGVARQTDGPHNLGDHERKVASAFGYDLEDLRSIPETANLGVSCGNPLATANIKVGEVVIDLGSGGGIDVLLAAKKVGVEGKAIGIDMTKDMLELARQNAKNAGASNASFIEAFITSIPLPSSTADCIISNCVINLVPEVEKPLVFQEMFRLLKPGGRVAISDILAKQELPMEIKKDLSLYVGCIAGASQVADYERYLKEAGFQDAVILDTNADLNIYKEMWKREESNRPGPASSCCDPMNNSASRDNLPDVDFNIWTGSFKIFAIKPDIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB08</accession>
    <name>A0A2I2GB08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_435269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705339.1">
        <property type="nucleotide sequence ID" value="XM_024848903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB08"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB08"/>
    <dbReference type="GeneID" id="36556602"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435269"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032633">
        <property type="entry name" value="ThiJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF22">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17124">
        <property type="entry name" value="ThiJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="252" mass="27529" checksum="06D296D588E1B7BA" modified="2018-02-28" version="1">MPPKKVLIVLSDAHSFPIKKTSGPEAGQTVDQPSGFFLMELAKPLQKFLDAGHEVTFASPKGQEPAPDPNSESLLAFAGNFYERRRETELIERMKRENGFTRPRPFSTISDDELATFAGVFIPGGHAPLSDLGGDAELGRILRFFNKENKPTAAICHGPYALLSTKKVGDGTFVYKGYDITAWSDAEEKMMETLWGGEVEKVESALRNEGANMVEGAKEVTGGVTLHRELLTGGNPLAAEELGNRFLRMLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB42</accession>
    <name>A0A2I2GB42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_435281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705369.1">
        <property type="nucleotide sequence ID" value="XM_024848904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB42"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB42"/>
    <dbReference type="GeneID" id="36556603"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435281"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="88"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="35187" checksum="31EC0B4718C95EFD" modified="2018-02-28" version="1">MSNPGDYSAVRRDIVAQLKKPDYDDGSAGPVFVRLAWHSAGTYDAESDTGGTNGAGMRYEAEGGDPANAGLQHGRAFLEPVKEKNPWITYSDLWTLAGVVAVEEMGGPKVAWKPGRTDLVDDSKVPPRGRLPDGAQGADHLRFIFYRMGFNDQEIVALAGGHNLGRCHMDRSGFEGPWVNNPTRFSNQFFKLLLKLEWKPRTLSNGVQQFNYVDPDADEDDEPLMMLPTDISLIIDPSFRPWVERYAEDKDLFFDHFAKVFAKLIELGIRRDEKGVIVNTDNVKGGYVSAAKKSNTATGPPKNEGGCPRAQGGCPRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB69</accession>
    <name>A0A2I2GB69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative NADPH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_404889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705426.1">
        <property type="nucleotide sequence ID" value="XM_024846555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB69"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB69"/>
    <dbReference type="GeneID" id="36554254"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404889"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000029">
        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="240"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="554" mass="63656" checksum="ACE67880DF335734" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBI3</accession>
    <name>A0A2I2GBI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_473807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705540.1">
        <property type="nucleotide sequence ID" value="XM_024853081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBI3"/>
    <dbReference type="GeneID" id="36560779"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473807"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="181" mass="20711" checksum="42B849EC6496A34D" modified="2018-02-28" version="1">MNGGNQTPPMVDVDILPERRKWMTGDAGEKKKKKRDDDDNQINPTRLHPQSQEAETFFSVPFFGPSDQEAFRPGNQSPGASSFLLALIYLSLYEYGRSTGPRLKIRCVSNPIALRPSTAWKNAPDQRRDDPEVPEGEQRPTDTFQLDRPKMTVIPLKSVSAEHRQRRPCRSAWRIHEWPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCK3</accession>
    <name>A0A2I2GCK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_455086</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705913.1">
        <property type="nucleotide sequence ID" value="XM_024851499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCK3"/>
    <dbReference type="GeneID" id="36559198"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455086"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="15">
        <location>
            <begin position="181"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="13">
        <location>
            <begin position="328"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB50611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="808" mass="86304" checksum="37E3B835C5260587" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD05</accession>
    <name>A0A2I2GD05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_154547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706070.1">
        <property type="nucleotide sequence ID" value="XM_024842535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD05"/>
    <dbReference type="GeneID" id="36550232"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_154547"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="150" mass="17147" checksum="D7620ACE94B7D81F" modified="2018-02-28" version="1">MQRQGGEVQLYNTQPLAGEFRAFHESLQRLPIRPTPLGANSSPSAGALANIRPRCAVGRIRRRDAALAGCLCGFRSILVIREMMPNNSVWLVRQITDYRSDDFHLTVEWTDDSASRGRIISDLFIFPDFLFTRFPLLLAYQFRLEYLQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD38</accession>
    <name>A0A2I2GD38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_425102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706101.1">
        <property type="nucleotide sequence ID" value="XM_024847600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD38"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD38"/>
    <dbReference type="GeneID" id="36555299"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425102"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="276" mass="29980" checksum="D1D79D36F861BEA5" modified="2018-02-28" version="1">MSMTIQDAGQVREGFPRPFTNTATNVFEQLSMTGKVVAITGAADGIGLAVVEAISEAGGNVALLYNSNKAAIERSQELAKKHNVKTQAYQVDVSESVQVEETVKKVVQDFGRIDVFVANAGMAISKPILEQTLPEYEQQMSVNVNGIVYCAKYAGELFKRQGFGNLIITSSISGHIVNVPVDQPVYNGSKAYVTHFGKSLAREWREFARVNIVSPGFFDTKMGASPLCINEAYRMSPMGRQGHVKEIKGLYLYLSSDASSYMTGSDVLIDGGYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD43</accession>
    <name>A0A2I2GD43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_425110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706110.1">
        <property type="nucleotide sequence ID" value="XM_024847603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD43"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD43"/>
    <dbReference type="GeneID" id="36555302"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425110"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014161566" evidence="3">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="156" mass="17926" checksum="8A935564137E23EE" modified="2018-02-28" version="1">MLTLIISIWLNIYLAVGDVNIPLNKLPLLNKSTDGEWKRVAPEHGGGVYALIETFHQIHCLLSGRKDVIRQYTYRDEWDYSKTPAFDAEPHLVRAHVDHCIETIRLNLMCVGDVTPFLTISSPSRPLGELPDFNTKHKCRNFTKLQEWMRQNSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD92</accession>
    <name>A0A2I2GD92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_463924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706144.1">
        <property type="nucleotide sequence ID" value="XM_024852204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD92"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD92"/>
    <dbReference type="GeneID" id="36559902"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463924"/>
    <dbReference type="OrthoDB" id="4526765at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="2">
        <location>
            <begin position="292"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="47151" checksum="27C7A35E899E7E26" modified="2018-02-28" version="1">MATSGIGRDQTCQSRLRKLLLGAVSNLKFLRRGQKHGIVRGARTWTGQHIVSQHHTLNQSAAELKMPDSTDPIEYLLSDSTVQVLRRGRDTFLAFCGTDTMEPSYTSPLYQWASNSVYCIAVKRYRCGGYGSTVRDGMASAIDLAQAGVDTMQALKDQTHTEAQMDLFEYMFSFAVKTVDGRRQIGPSDWDWINRIFDKVLKLKSFKEEKMAEDVVIYCDHSRYIEGTECNGNKNKKMACDKDISGDVEINSVFKWCKSKSGYFPVMADLGSKSLLAWPIHKIYNVTLLRTNMDAAALLDRTILHELTHAIPLLATTDTSCFLSYGWKRCVTLGKSRDSGINNADNYAYFALGARMISPTDNKPPQRPNRDGSVSLLPPDLWRSQQSHSLRARYFGRTANSSALGENASFNEAKKSLIMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDE0</accession>
    <name>A0A2I2GDE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conidial pigment biosynthesis scytalone dehydratase Arp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_436001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706211.1">
        <property type="nucleotide sequence ID" value="XM_024849064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDE0"/>
    <dbReference type="GeneID" id="36556763"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436001"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="155" mass="16939" checksum="81FD656212FF1ADC" modified="2018-02-28" version="1">MSDPSIPLACQNLLHDWATSIDTKSWARMPAIFAPTIDVDYSALGQPKATAVQPSVYISQFSDPNQLGNPDIQSHHLVGACKWTRESESRASVDFQIMTVLRRAPRDGNAAVLATGHGVNTMEFTQVDGEWKIAALKVEVLWIDGDFAAIFAPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDK7</accession>
    <name>A0A2I2GDK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-peptide hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acylaminoacyl-peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_381963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. Also, involved in the degradation of oxidized and glycated proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706223.1">
        <property type="nucleotide sequence ID" value="XM_024845590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDK7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDK7"/>
    <dbReference type="GeneID" id="36553289"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381963"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="6">
        <location>
            <begin position="448"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="658" mass="72407" checksum="8E2896E170BE736E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDT2</accession>
    <name>A0A2I2GDT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1753-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_436137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706361.1">
        <property type="nucleotide sequence ID" value="XM_024849093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDT2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDT2"/>
    <dbReference type="GeneID" id="36556792"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436137"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="345" mass="38476" checksum="1585F832298F5625" modified="2018-02-28" version="1">MGLSTRFLRIPRPETFLYVMSLRTGAALITLSLLLNKISGLYGLLALLTGYHLSPVQLSMYIYSLIALGLATILFPHIRKQSPLQCLALAWLYVFDSIINAAYTATFGVTWFLVVSQHYENGTVSGPGSETIAQTAGFTSPKYDDSYTESTYTESTDGSNYARSSEGLSNAVTQPESFQSILFICTLWVVRAYFVFVMLAFARQALRIYIAVPRHTQLPTHSRNTSNASVASVADIDREPFSPFSPEGQGWQGKLGRAMISVGRNYWLGEDEEGTSWMNNIGRRFRTRLENTELPGPLERERRRRSGTGPPQPSQSAVQAAALQQPIYEQAPGMNVKMQDWTENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEX0</accession>
    <name>A0A2I2GEX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative short chain type dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_453171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706731.1">
        <property type="nucleotide sequence ID" value="XM_024851339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEX0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEX0"/>
    <dbReference type="GeneID" id="36559038"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453171"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014192170" evidence="3">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="228" mass="24669" checksum="8DF0C356FDF6EFBF" modified="2018-02-28" version="1">MTFSPILLILGAGPNVASSTAALFAAQGYKIALVSRGFSASFDSSYTHIKADLTVPGTVHTAFEEVKAKFGNPPNVVIHNAYHVFPAAPGNPLTLSQHELEHDLAVNFTSAYLTAQEAVKGFASLPDDVPKSFIYTANGLNLMPQPRLVSLGVGKIAMGHVIENAVLAFKGKGYTFYYGDERLDNGDYASGAISGPAHAERYWELSQDRTQHEWMDTFVAGKGYKKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF46</accession>
    <name>A0A2I2GF46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_453197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706783.1">
        <property type="nucleotide sequence ID" value="XM_024851342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF46"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF46"/>
    <dbReference type="GeneID" id="36559041"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453197"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="263" mass="30282" checksum="DC726216B0F40D04" modified="2018-02-28" version="1">MESVTESRDRYNLRKALTVMERDINALEKTDMHTLDQGVLKRCRVRTLPLSLEGDDSLAPTFFMALAPENMPEPTEEYVDREYSTDSLTLSSERGRLIYLYLSSYVRKLMIDLPEVQRTWSSNQIGDYNFGDLYRTFPPEFGTLSIIHVAKASKPHIKCIMHNDLDADDSHLLRGEILTVIRIMLGQLKQKVFVNHMVAPVLLFSMNRRHPRVIEAYFDGQELLMRRTSSYDFTFLNADGFKTFAQWFLGGPIGDTSRGLART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFC1</accession>
    <name>A0A2I2GFC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_461780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706877.1">
        <property type="nucleotide sequence ID" value="XM_024852060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFC1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFC1"/>
    <dbReference type="GeneID" id="36559758"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461780"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20448" checksum="BDE7983BE6B271D9" modified="2018-02-28" version="1">MRMEILGLSALAALIPLPTHKQIFLYNKTFGADPQTDNTTVAAWDSLLPAINPYPVLGNKQTVGQSSVRYPPGSQNIYTLSVAHQLHCLWSIHQNYYSAVHGAPDRQGDHIAAHMRHCFDYLRQSLICASDSTLEPVDTKLGGVTGWGSERVCRDYAALSEWAEGRRVSNARGFSGHDTNQGGVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFF2</accession>
    <name>A0A2I2GFF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_352630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706911.1">
        <property type="nucleotide sequence ID" value="XM_024843931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFF2"/>
    <dbReference type="GeneID" id="36551631"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352630"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="74" mass="8672" checksum="5793BB3F66AF1423" modified="2018-02-28" version="1">MKEEKNKHPNKIKINLISNTKEQDTIINNKIRLDKINKICEIGEAQIPLSKNNTQVQVSGQKRKSRDNNIFKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFT1</accession>
    <name>A0A2I2GFT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_83457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706999.1">
        <property type="nucleotide sequence ID" value="XM_024855406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFT1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFT1"/>
    <dbReference type="GeneID" id="36563113"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_83457"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="489" mass="52547" checksum="6E822EF3E37C26F7" modified="2018-02-28" version="1">MSGLNPFRPKKPEDPAGPPSSHSTSGSSYFSVPPAYTVPDTSFNPNGIPDFPSPNPTPSNDDSLSSDDQSVSDPFRQHSDLSDDEGVRRKPAQFPTSNPSNLSRELPDEEFRRTRQPGLPSAPPVSATAFGVPAGLPSRSRTHDQYPGQENARPLGENAPVASSNASIRSLTPHGGTRTTNSSVTDVSQTPAHPGIAHFPGVGRDPKPLASRSGNRDKVPPPPPKSHHGRLISPTSGTASSLSQPEPARPTNRYSFHGSPSEASLSPRPAQSEGGYFAGLGEKSQLERPGESLRRSQSQHKRPPTPPLARRHSQMRRSKTTHSKANMARLSMPPIKVDVTAESPPPSPGSWSLNPARTRDARIDTSSSDENSSQRPPLSIQTSESKSSTSVADTSASTSPSNPRASLNKRASQQNPLPPPPPPRRTRGSSNHSSDETRSTSLRSEKRAEENPAFTPEPSNARDILADLTRLQKEVDDLRGHYENRKASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFU9</accession>
    <name>A0A2I2GFU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_85925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707067.1">
        <property type="nucleotide sequence ID" value="XM_024855418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFU9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFU9"/>
    <dbReference type="GeneID" id="36563125"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_85925"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="484"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="609"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="652" mass="72156" checksum="44124A9505FF9C8C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH90</accession>
    <name>A0A2I2GH90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_453692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707544.1">
        <property type="nucleotide sequence ID" value="XM_024851380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH90"/>
    <dbReference type="GeneID" id="36559079"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453692"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="141"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="606" mass="64704" checksum="33ABD27D36A2FFFF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHS6</accession>
    <name>A0A2I2GHS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_462380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707731.1">
        <property type="nucleotide sequence ID" value="XM_024852098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHS6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHS6"/>
    <dbReference type="GeneID" id="36559796"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462380"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="642" mass="69673" checksum="F0861E6B61F83FBD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIA0</accession>
    <name>A0A2I2GIA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_453898</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a complex with LTO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707869.1">
        <property type="nucleotide sequence ID" value="XM_024851396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIA0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIA0"/>
    <dbReference type="GeneID" id="36559095"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453898"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="11">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="229" mass="24470" checksum="D9B050598FEA5432" modified="2018-02-28" version="1">MTSPNAPIDNTLDDIFGSSPPHEPSHAPAPKDSTPSVEPSELPFLRRQHVTAGYREGISTSKGEHVQEGFDAGFPVGAQLGMRAGTVLGILEGVMRGYESRAASAVVKKQPGRAGGAGPAPSAGAKKGEEQGRELDEEARRARRDEMVKLYQRAVKALSVQGVFGTLEEGGEGKESAETQLAGKGDGVVSKWEDRVRVAHWEENMDVLQMKEDGQPSATSRTQQIQSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJH9</accession>
    <name>A0A2I2GJH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_434756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708332.1">
        <property type="nucleotide sequence ID" value="XM_024848788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJH9"/>
    <dbReference type="GeneID" id="36556487"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434756"/>
    <dbReference type="OrthoDB" id="4412445at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673:SF1">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="79" mass="8478" checksum="CADB6F450708ECAC" modified="2018-02-28" version="1">MCDVPFLPIFPLCFQCGTDQNPCRCKVVGPTLGFCVTVVAAVICYPASIFCGCCLTQKGKDCLGYPVKLNQKVANCIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJI8</accession>
    <name>A0A2I2GJI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_472898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708319.1">
        <property type="nucleotide sequence ID" value="XM_024852993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJI8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJI8"/>
    <dbReference type="GeneID" id="36560691"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472898"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="295" mass="34647" checksum="6F52AEB036A6ED3D" modified="2018-02-28" version="1">MTEVSSTRLYLGNLPRNDIEEHFSTHGSGKITEIKLMNGFGFIEYEDAMDARDVVPAFHGSDFKGERLTVQFARGPRRKENFPGPMDRPAMPRPRRTIFRMMVSGLPETSWQDLKDFARQSGLDVVYSETGRELGRGFVEFETANDLKTAIDKLDGRDFKGSRVSCVADIQSFDDRTFRDPYRSRSPRRSYPPVDEYDRRFPAPRGYSPRAHYRERSPIPMRRDYYDRDGYGRRTPPRPRIEDYPAPRRPYDDPYDVRPPPPPRYEDPYIPPRPYGRPRSPPRGEYVPYDRRGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJS3</accession>
    <name>A0A2I2GJS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_379576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708422.1">
        <property type="nucleotide sequence ID" value="XM_024845489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJS3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJS3"/>
    <dbReference type="GeneID" id="36553188"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379576"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="537" mass="58808" checksum="330F592491B891F5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK87</accession>
    <name>A0A2I2GK87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-dependent oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_404305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708595.1">
        <property type="nucleotide sequence ID" value="XM_024846519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK87"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK87"/>
    <dbReference type="GeneID" id="36554218"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404305"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF287">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="406" mass="44811" checksum="29CAC5467AA5F45D" modified="2018-02-28" version="1">MSSTSFPTTPSQKHYDVVIIGGATSGTSIAWHLSTNPDFSGSVLVVERDPSLQYSATKASNNCMRQQFATKINIEIAQYAADFAKRFGANFGLDPCVPQPPIRDFGYLYLSDSESFTKVLEKDQQLQSRLGAGTQIIPTTDIKERYPFFYTDDLDSGSLNTKDEGCFNAFGMVEWMRKTSCDNGIEYICNEVVNMVIDKGQIQAIELLDGERISADKVINAAGTRAAQVASLVGVELPIEARRRYTYIFSVDDPLSQDLPLTIDPSGVHLRSYADKDYLVGCPPTGADVAVDVNDFSFAENAWDEKVFPIISRRIPQFSTARVTDSWMGHYEFNTFDHNAVVGAHNSIRNFLFCVGFSGHGSQQAPACGRGIAELVVYGEFKTLDLSALSYTRILEGRPLTERAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKH7</accession>
    <name>A0A2I2GKH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">P170DRAFT_463095</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708695.1">
        <property type="nucleotide sequence ID" value="XM_024852137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKH7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKH7"/>
    <dbReference type="GeneID" id="36559835"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463095"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000426">
        <property type="entry name" value="Serine/threonine-protein kinase ssn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="41"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="391"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="PLB53393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="428" mass="48308" checksum="D48BE80CF4650FCA" modified="2018-02-28" version="1">MFGRNFPFFNSIGGFYPRDNIDPRKPTGTGYTSKVRVRDKYHIVGFISSGTYGRVYKAVGKNGQKGEFAIKKFKPDKEGEIIQYTGLSQSAIREMSLCSELDHPNVVQLEEIILEDKCIFMVFEYTEHDLLQIIHHHTQPQRHAIPAPMVRSILFQLLNGLLYLHTNWVLHRDLKPANILVTSKGAIRVGDLGLARLFYKPLNSLFSGDKVVVTIWYRAPELLMGSRHYTPAVDLWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMMKIIEIMGLPTKDAWPGIVSMPEYSQLQSLAMSRAPSHLPRSSNLENWYQNCLKNGGYSSASNAGTPGADGFDLLSRLLEYDPTKRITAREALEHPFFRNGGPIPANCFEGFEGKYPHRRVTQDDNDIRTGSLPGTKRSGLPDDSLMGRAAKRLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKL7</accession>
    <name>A0A2I2GKL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_376269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708728.1">
        <property type="nucleotide sequence ID" value="XM_024845362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKL7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKL7"/>
    <dbReference type="GeneID" id="36553062"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376269"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="426"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="628" mass="71565" checksum="801AFA9F31629383" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLL6</accession>
    <name>A0A2I2GLL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacid aminotransferase-like PLP-dependent enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_346133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709065.1">
        <property type="nucleotide sequence ID" value="XM_024843549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLL6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLL6"/>
    <dbReference type="GeneID" id="36551249"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346133"/>
    <dbReference type="OrthoDB" id="5288718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30072" checksum="DB97C1A3BFA34447" modified="2018-02-28" version="1">MDKEMASSFQIISTLRYDPALPNVLRASPSESYPDTLCTPYYLLPYHQDRLLSAAQCFKWQAAIEFLEKDRDQFLQFLDTFIPDKTKPWRLRIVIDQHGVGTVEANPTTTIDLSGLLVPSETNTSSSPWRVYVDTQPTTPSAFTTHKTTARDDYTSARLRSGIQSPQEQAEVLVVNPQGEIMEGSITTPYFRRKESVSETDDRAGQAIGPDWITPPLSSGGNAGTTRRYALAQGFCTEKIIRATDLIDGEECWLSNGARGFIRGIVVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNJ4</accession>
    <name>A0A2I2GNJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nuclear envelope protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_460570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709731.1">
        <property type="nucleotide sequence ID" value="XM_024851950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNJ4"/>
    <dbReference type="GeneID" id="36559648"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460570"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB54429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72654" checksum="08879C596FCFFAC8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNP1</accession>
    <name>A0A2I2GNP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_432148</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709799.1">
        <property type="nucleotide sequence ID" value="XM_024848198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNP1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNP1"/>
    <dbReference type="GeneID" id="36555897"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432148"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB54497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="217" mass="21512" checksum="4AC91CE3686A5292" modified="2018-02-28" version="1">MAANKQGKMQNLINYRMRVTLNDGRQMTGQMLAFDKHMNLVLADTEEFRRVKRKSKPAAAPSTTPLVESEEKRTLGLTIVRGTHVVSCSVDGPPPADPSTRLGTSGPGAAAAAATLAAGPGISKPAGRGLPVGLGGPAAGVGGPPPPGGFPGFPPGGFPGAPPGFGGRGGPPGGPPGFAPPPGFAPQGGPPGAFQPPPGFQPPGQGRGFPPPGFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNZ1</accession>
    <name>A0A2I2GNZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED8</name>
        <name evidence="13" type="ORF">P170DRAFT_398257</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398257"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1710:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB54595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="26813" checksum="0EEF32CA2503B2AB" modified="2018-02-28" version="1">MSAPTQDQIKTLEQSRQRLVQLTRSLASLITSLHQGETLPPWSSLQSQASIISNNLLSVSEHLSENHDLLSSLVAYPGPSYPGRTQSNILEQLLRTKLDPRVDDWVARGRKAGDSALQDIAGLSESQLAELWHWAPVEANQQARGRNWGGNFTLEERNMGVQNVVTGLKRQLEDEDDEGRSDEEEEDEVEDEMEVVGVRRKSGAGSGLEFDIAAATHQKPTGPVVPLNEILRFMTTGAPPGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP07</accession>
    <name>A0A2I2GP07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_432233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709911.1">
        <property type="nucleotide sequence ID" value="XM_024848219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP07"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP07"/>
    <dbReference type="GeneID" id="36555918"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432233"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="542" mass="60302" checksum="19F7C79A5245A837" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPE1</accession>
    <name>A0A2I2GPE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI ethanolamine phosphate transferase 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_505441</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710044.1">
        <property type="nucleotide sequence ID" value="XM_024854288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPE1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPE1"/>
    <dbReference type="GeneID" id="36561994"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505441"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="934"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="965"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="13">
        <location>
            <begin position="837"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB54742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="996" mass="110219" checksum="1893ADFB4871C1DC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPL1</accession>
    <name>A0A2I2GPL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_470255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710117.1">
        <property type="nucleotide sequence ID" value="XM_024852730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPL1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPL1"/>
    <dbReference type="GeneID" id="36560428"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470255"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="76" mass="9192" checksum="9ED2C0F9A955667A" modified="2018-02-28" version="1">MFRTAPRMAGFVFRENRVPFYQRLFQQHDGKRQWWKTDRSPYVMYPYLLSVYGLGLATTYAMGRMVFGHKTWFGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPR6</accession>
    <name>A0A2I2GPR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_505535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710170.1">
        <property type="nucleotide sequence ID" value="XM_024854296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPR6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPR6"/>
    <dbReference type="GeneID" id="36562002"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505535"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="208"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="685" mass="75841" checksum="00BF78CACC298FAB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPW2</accession>
    <name>A0A2I2GPW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_26637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710216.1">
        <property type="nucleotide sequence ID" value="XM_024843117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPW2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPW2"/>
    <dbReference type="GeneID" id="36550816"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_26637"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF5">
        <property type="entry name" value="CHLOROHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="56"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="499" mass="54372" checksum="4C7CE8DBB63072FB" modified="2018-02-28" version="1">MTTSILLKQGTLLIHDHDVIRAEQKDLLVEDSIICQIDDSINQPQSATVIDCSGKIISPGFIDTHHHVWQSCLKGTHADQTLVDYFWDGNFISSFLSPQDVFWSQLAGALECVDSGTTTVVDHAHINYSPEHSTEALRATIASGLRSVFAYCPTPRVASWKPEFTLDRDFLPPWVMETFKKLAGLNPFGPNGRVSLGFAFDGLFLPGSMLKDMYSKVREAGAQLITSHSVYGAQFGAPNQTSAAATLDDNGLLGPDILLSHNNNPTPQDARLVTDKKVKISSTPGTELQMGHGNPVCLRDDLYAQASLGIDCHSVCSAYMPAQMMLALQWARARRHEDLESQDKWSSDVGFSASSVFNLGTIHGARAIGMEDTVGSLAVGKKADLVVFDCTTPGMIVAADRDPVAAIVLHSTVRDVNTVIIDGVIRKKDGTLQPVLAPESISEKVDQGQKIEWKDIVPYVMELSRRADEKKKTTVDGKSAKKAIMEAFHMNVEGHVGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQR1</accession>
    <name>A0A2I2GQR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_432750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710520.1">
        <property type="nucleotide sequence ID" value="XM_024848332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQR1"/>
    <dbReference type="GeneID" id="36556031"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432750"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="119" mass="12852" checksum="FD683B3CA606C558" modified="2018-02-28" version="1">MTKSPAKVWHCHNAVSTCLRETFCRNADWIRTNSNFTANSNQTNQTNGSSQAVQPAMFPTSRVGVVAHPLPMPTDHVSAAIDLSTPDYAPASRPLAIDTCGIGPQTDDAMPNLRQSITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQT4</accession>
    <name>A0A2I2GQT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_35935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710523.1">
        <property type="nucleotide sequence ID" value="XM_024844349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQT4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQT4"/>
    <dbReference type="GeneID" id="36552049"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_35935"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="207" mass="22660" checksum="4C5287B5B8BB0F3B" modified="2018-02-28" version="1">MSDKEDNPQTPAQENENTTPKPQEEQEQEQDNGPTSPQPKEEGQDNGPASPQPKQEEDDNKKTFKQEPDSDNEPAPQREPAPERRQRRPRPQRTRQDSGAMENTTEKPRRQRRQRRQPQEQDGGPLGGLGGVDQVGDLVQNTAGNAVNGVTDSAGKAVGGILGGGKNEGGEEGGKDEQLRLRLDLNLDIEVQLKAKIHGDLTLGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQX1</accession>
    <name>A0A2I2GQX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_421860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710581.1">
        <property type="nucleotide sequence ID" value="XM_024847391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQX1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQX1"/>
    <dbReference type="GeneID" id="36555090"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421860"/>
    <dbReference type="OrthoDB" id="5380163at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="154"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="612" mass="66796" checksum="D8B40C935514E8FE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRZ1</accession>
    <name>A0A2I2GRZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_399937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710950.1">
        <property type="nucleotide sequence ID" value="XM_024846301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRZ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRZ1"/>
    <dbReference type="GeneID" id="36554000"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399937"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="62"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="447" mass="50557" checksum="2FE468D17A36DD79" modified="2018-02-28" version="1">MAAKLVDRRIHSIPGKLRVAELFFDVPLNHSQPNDGTLRLFARSVRRHNKPVQPTKDEPRLPWLVYLQGGPGMGCRPPQEYGWIGTALEKGYQVLFLDQRGTGLSSTITAGTLALQGNAIKQAEYLKHFRADNIVRDCEAVRRCLTTDYPEEERKWSIIGQSFGGFCAVTYLSLFPEGLREAYLCGGLPPLVDGPDPVYALTFEKVIERNKAYYAKFPEDVDRVKQIVKYLQDNQVAVPSGTLTPERFQQLGIMFGMHGGLDSIHDLVLRASHDLELFGFLTVPTLNAIDSYGGFDSNIIYAILHEAIYCQGQPSNWSSDRYRAANSQFHINTDLPEIWFTGEMVFKDMFDSYDELNKVKEAADILATTNDWPALYDEEKLAQNTVPVYAASYVEDMYVHFHHASNTAAKIEGIKQFITNTMYHNAIRSKPDELLQQLFALRDDTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSF3</accession>
    <name>A0A2I2GSF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-xylanase</fullName>
            <ecNumber evidence="11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_471212</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711116.1">
        <property type="nucleotide sequence ID" value="XM_024852820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSF3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSF3"/>
    <dbReference type="GeneID" id="36560518"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471212"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014117067" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB55814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="345" mass="39012" checksum="273C16EFA4C24CE9" modified="2018-02-28" version="1">MKTNTLIALSALPSLGLALSTGPTKQPGLNSLMEKRGKLYFGTINEVNYLNDTKHTAILSNRNEFGQITPENSQKFAATEPQRGVFNFTNADRLVDRALARGQEVRCHNLVWYNGLPEWLTLGTWDRPTLLDIMENHIKHVVQHYRGRCYAWDVVNEAFNEDGSYRDTIWYKTIGPEYIPLAYELAAKYDPMAKLYYNDYGIEFVNNKSVASARLVQDLRAQGVKLDGVGLQGHLPAIQSPNYDDQMAGLKLFTDLGVEVAYTELDVFIQMPNNAAKTAQQAQAYVDTLRACLDTPKCAGITLWGFYDPYSWVWEGVPGFGDPCLWDARYNKKPVYDEMAKVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQS0</accession>
    <name>A0A2I2FQS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_487022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698261.1">
        <property type="nucleotide sequence ID" value="XM_024853944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQS0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FQS0"/>
    <dbReference type="GeneID" id="36561644"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_487022"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="223" mass="23719" checksum="70A9F190552BF0EC" modified="2018-02-28" version="1">MALTRRPYLPASVFPPIPPGPLRAPTGLAVGHPRSIRPGTRPPPDLLPQAPDRPVPFRSGAHPPPDLLPQAPDRPRAFSVRRPPTPGPFAPGTGPPPCLLPRAPHPPDRFASRPRPLASRDHSHPASQGTLPRQLVRQWAFVPYLAPTRQAPSTSLYSPQAPSAPTGLAVGHPRSIRPGTRPPPDRPRAFSVRRPPAPGPFAPGPLPARRGTPQPGDARPGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQV1</accession>
    <name>A0A2I2FQV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_78608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB42991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_78608"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="64" mass="7601" checksum="E120323874C2102F" modified="2018-02-28" version="1">MRFPRRKGPAGPVLAVRRTGQPDPRFNYELFNCNNFNIRYWSWNYRGCWHQTCPPILVIGMSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRR6</accession>
    <name>A0A2I2FRR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_370333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698626.1">
        <property type="nucleotide sequence ID" value="XM_024844949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRR6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRR6"/>
    <dbReference type="GeneID" id="36552649"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370333"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="545" mass="60050" checksum="34F6C79AC08E1C27" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS27</accession>
    <name>A0A2I2FS27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_486361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698740.1">
        <property type="nucleotide sequence ID" value="XM_024853931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS27"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS27"/>
    <dbReference type="GeneID" id="36561629"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_486361"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="30"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="202" mass="22783" checksum="4F5422174BA87C72" modified="2018-02-28" version="1">MEFLQQLEISEATFVMASNSKTYIFGGDQPWSPHDWTASDDRVRGGASHSYLECDPPSNAARFHGHLDIHALGGAGFASQRTTGDRMWDLTGNDGLELDIRQSDGKKYTLTLKDTVLPKRPDGREQSTINWEYDFHATDKGPFVIRWKDFRATYRGKDKEDAPPLDRSSIKRISIMMRSFFGTQEGDFSLEIASIAAIQTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSU0</accession>
    <name>A0A2I2FSU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_430735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699002.1">
        <property type="nucleotide sequence ID" value="XM_024847973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSU0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSU0"/>
    <dbReference type="GeneID" id="36555672"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430735"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="372"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="634" mass="72310" checksum="0E510CE801923111" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSU8</accession>
    <name>A0A2I2FSU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_480669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699012.1">
        <property type="nucleotide sequence ID" value="XM_024853803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSU8"/>
    <dbReference type="GeneID" id="36561501"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480669"/>
    <dbReference type="OrthoDB" id="4506631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014154582" evidence="1">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="195" mass="21305" checksum="D3C463883167F274" modified="2018-02-28" version="1">MSFFWGSLLGLSLVAYSNASPRPDLPHGYTLVKSTDAGKSTTYEEIGFYSSATTPGASATFVPKYDATVVSGKTLPFVTTTDDAGTPVTWIGDWNTNSAGSSSLIPVQVCSEIAQPLEGRSKLLQRRDLVCAEVSAFTSRPVQTTTPKSPTLTSPTINFIEAEFVDSNIYFAYKEPDLEPDLEYLITELYYREQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSV1</accession>
    <name>A0A2I2FSV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_441152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698993.1">
        <property type="nucleotide sequence ID" value="XM_024850248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSV1"/>
    <dbReference type="GeneID" id="36557947"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441152"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="61" mass="6450" checksum="94EBAD5F8A0DB38B" modified="2018-02-28" version="1">MMAMPMAPTMATMAVVAMTMTMSPPASSIMRRGMMRAAVVVLVVALPTTAFTHLVAQIVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTK4</accession>
    <name>A0A2I2FTK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_394116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699280.1">
        <property type="nucleotide sequence ID" value="XM_024846046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTK4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTK4"/>
    <dbReference type="GeneID" id="36553745"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394116"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="11">
        <location>
            <begin position="145"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB43978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="241" mass="26775" checksum="D33931C30E063BBA" modified="2018-02-28" version="1">MPAPTALRRTEDEPVIDFNTGVPQAAPAANDDDEVLVDMDSAPPAPIHLTADSQPQNLVHIQTRKVPIPPHRFTPIKAEWPKIYPPLCDHLKLQVRMNIKNKSVEMRSSKFTTDSGALQKGEDFVRALAYGFDVEDAIALLRLDDLFIETFEIKDVKMSLQGDHLARAIGRIAGKDGKMRYSIENASRTRIVLAGQKVHILGGFQNIRMAREAVVSLVLGSPPGKVYGNLRTIASRRKMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU43</accession>
    <name>A0A2I2FU43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_467896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699436.1">
        <property type="nucleotide sequence ID" value="XM_024852500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU43"/>
    <dbReference type="GeneID" id="36560198"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467896"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="158" mass="17768" checksum="04931A708A94A7EC" modified="2018-02-28" version="1">MTSLQGLSIIEATPDHVPTIKAMVVAAYSKYIPRIGKPPAPMVADYYELLKTREIYALERLEDGRIVGSVVLRMDTDTASININNLVVDPGAQGKGYGRLLMDFAEGLGKERGCKAVVLFTNIKMYENLALYPKLGFVETDRREEDGYERVFYRKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUH9</accession>
    <name>A0A2I2FUH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fcf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_458881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699528.1">
        <property type="nucleotide sequence ID" value="XM_024851827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUH9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUH9"/>
    <dbReference type="GeneID" id="36559525"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458881"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000039">
        <property type="entry name" value="rRNA-processing protein FCF1 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="8">
        <location>
            <begin position="64"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="523" mass="58025" checksum="6CF4CF885A5383B5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUT3</accession>
    <name>A0A2I2FUT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_430303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699707.1">
        <property type="nucleotide sequence ID" value="XM_024847942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUT3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUT3"/>
    <dbReference type="GeneID" id="36555641"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430303"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="396" mass="43885" checksum="54DE0BF6F890868D" modified="2018-02-28" version="1">MSSSTTYESTYIEVTPDKHGAFVIIASLVGLIWSVFIIGIRVYLRMRLTPPFGWDDLAAIFGTIVGVIQTSVTLDAVNHGIGTRETLLTSSEADIALKRLYVSWLLYPVAVCSSKVSIALLIARLTRTKYHLWASYALTTLSLLWGIISIFLIAFQCSTPQPWNIAATTQCSTMFAQWAVVESVNMAIELLIPCLIIAMIWSLHMPLGTKITVVLAFSLQLLYVILLIHYVTLKTHHIRSPRVVFPTIIRILFLQQTTTTPASRTDHTFTLTNSTLITEVVMHFSLIAATFPCLRKFLQAFDMHMGATTNLTSEGDTGSSSIALKSLERSPNPEIYRAMPPAPGMGTVTVVSTVSQKSQDSRGDVTPAERRSEESDGSQRVMIRKTQRWEVVSSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVE7</accession>
    <name>A0A2I2FVE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_459088</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699879.1">
        <property type="nucleotide sequence ID" value="XM_024851840.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FVE7"/>
    <dbReference type="GeneID" id="36559538"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459088"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000003">
        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF79">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1078"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1262"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1129"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB44577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1294" mass="142451" checksum="04B5FE891C71DA56" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWH3</accession>
    <name>A0A2I2FWH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_479512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700280.1">
        <property type="nucleotide sequence ID" value="XM_024853690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWH3"/>
    <dbReference type="GeneID" id="36561388"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479512"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="14721" checksum="DEC3230FB81EF109" modified="2018-02-28" version="1">MTGQAVNLQLKRLVMRAQIWSWSADGRAARWCINSPSITPPLPLSFFPLQPSFDLRPSTFDLRYTFGPSTYFQHTTWTYGLGIDMGFDMDFDMDFDMDFDMDFDMDFDMDGTWLWASTWCIVRHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY77</accession>
    <name>A0A2I2FY77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_413933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700896.1">
        <property type="nucleotide sequence ID" value="XM_024846998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY77"/>
    <dbReference type="GeneID" id="36554697"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413933"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="145" mass="15691" checksum="B804016DA6BB9CCE" modified="2018-02-28" version="1">MDHSTQGWDFNPENYNARIESVSTGAGSPPSVTFRFTVTEDMCNYTRHLHGGCVSTVIDTLSTLFVAALSKPGLYSLGGVSRHLHTTYLRPVPVGSEVRLVCSLKHAGKKLVLLKANLHRVDDGGLCVIGVNEKANTDPPRGARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYT4</accession>
    <name>A0A2I2FYT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_414332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701096.1">
        <property type="nucleotide sequence ID" value="XM_024847013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYT4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYT4"/>
    <dbReference type="GeneID" id="36554712"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414332"/>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="855"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="845"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="848"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1146"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1222"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1264" mass="139202" checksum="3B7011A7BC39B8F3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYW2</accession>
    <name>A0A2I2FYW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_512440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701121.1">
        <property type="nucleotide sequence ID" value="XM_024854992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYW2"/>
    <dbReference type="GeneID" id="36562698"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512440"/>
    <dbReference type="OrthoDB" id="4161095at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="95" mass="10035" checksum="72318E45EC989246" modified="2018-02-28" version="1">MSEYYSSTSSSSFYSSSSGSNTNGQESGYRTATSSHTAPDGSTVVRSAEQDLGGPAVFEERRFDGDGRERLVGDSTTGHGGAGARRIENVDDEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ24</accession>
    <name>A0A2I2FZ24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_439588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701194.1">
        <property type="nucleotide sequence ID" value="XM_024849874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ24"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ24"/>
    <dbReference type="GeneID" id="36557573"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439588"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="393" mass="42695" checksum="62037418E2B68E3B" modified="2018-02-28" version="1">MPLPPSISTRSIATSTLNFHILEAGFTPSRDRPLLLLLHGFPELAYSWRKVIPPLADAGYYVVAPDQRGFGRTVGWDTRGFDAVDLSSFSLTTFVRDMLVLVHALGYRSVRCIVGHDCGAVTAAMCALARPDFFHSLVLLSHPFNGSPGLPFNTANDDDGDGSATTAASGGAESAAGDHVHAELAALGRKHYKWYYSTAPANGDMTAPAEGLHAFLRGYFHLKSGSWAGNQTYPLSGWTASDLAQLPYYYVMPLDDTMPQAVARHMGEETEAGERASHAWLPDEDLAVYVAEYGRTGFQGGLNWYRVRTAAGGKYTKDFEMFAGKKIEVPCAFVSGKSDWGIYQEPGALEKMANGTVCSDFRAMKLVDGVGHWAPQECPDEVVQVVLDLVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ66</accession>
    <name>A0A2I2FZ66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_390246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701231.1">
        <property type="nucleotide sequence ID" value="XM_024845897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ66"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ66"/>
    <dbReference type="GeneID" id="36553596"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_390246"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23811">
        <property type="entry name" value="UBCc_ScCDC34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000063">
        <property type="entry name" value="CDC34p Ubiquitin-conjugating enzyme (E2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="224" mass="25390" checksum="72507CAE0191EB30" modified="2018-02-28" version="1">MAERILMNEYKTLAKEPWVNIELNEEDIFNWTIGLIVLNPDSSYYGGYFKALMKFPKNYPYSPPEFRFLRPLYHPNIYEDGKLCISILHAPGEDEMSGELASERWSPAQRVESVLISILSLLDDAEVSSPANVDAGVMLRKDPEQYKSIVQINVEDSKNDIPEGFVMPTHQTTAAAKPVEKDDSDFWAESDADDDVFGGSDSDEDLNVDDQDTGTEEEDEKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZA0</accession>
    <name>A0A2I2FZA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_449542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701264.1">
        <property type="nucleotide sequence ID" value="XM_024851051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZA0"/>
    <dbReference type="GeneID" id="36558750"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449542"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF26">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="514" mass="57438" checksum="2EC0AFAA40C661C0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZB7</accession>
    <name>A0A2I2FZB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_365819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701283.1">
        <property type="nucleotide sequence ID" value="XM_024844727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZB7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZB7"/>
    <dbReference type="GeneID" id="36552427"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365819"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000003">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="336" mass="37766" checksum="0E1317D543FE0066" modified="2018-02-28" version="1">MDVRKKKRKVLLMGKSGSGKSSMRSIIFSNYVAKDVRRLGATIDVEHSHVKFMGNLTLNLWDCGGQDAFMETYLASQRGNIFSDVAVLIYVFDIESREVERDLDTYNAIINALKEFSPNAYVFCLVHKLDLIQAEHRQRIYEERSALIRSRSEHFSIDTFGSSIWDQSLYKAWAGIVHRLIPNLTVIERFLHAFAKRINAEEVILFERSTFLTVTSVASEVGDLNPIYDRHERLSNIMKAFKHCAARNTHTTPASAGFVVMHTKTPQFNVFLGRFTDNTYIFIVVPPGEAAYNCAVMNTMLAREGFSKAAATGQGDGFPLPAPDSPDGETILNSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZC0</accession>
    <name>A0A2I2FZC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_390363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701277.1">
        <property type="nucleotide sequence ID" value="XM_024845902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZC0"/>
    <dbReference type="SMR" id="A0A2I2FZC0"/>
    <dbReference type="GeneID" id="36553601"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_390363"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013986852" description="Hydrophobin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="158" mass="16010" checksum="65B0F2243B6F3E9A" modified="2018-02-28" version="1">MQFSITTVLAFAATVAALPPAVANGNGNGIGNKGNSQVRFPVPDDITVKQASEKCGDQAELSCCNKATYAGDTTNVDEGILAGALSNLIGAGSGSEGLGLFDQCSKLPLQVNIIAIALNDLVNQQCKQNIACCQNSPSDASDDLIGLGLPCIALGSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G073</accession>
    <name>A0A2I2G073_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_365832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701590.1">
        <property type="nucleotide sequence ID" value="XM_024844729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G073"/>
    <dbReference type="STRING" id="1392250.A0A2I2G073"/>
    <dbReference type="GeneID" id="36552429"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365832"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="345"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="677" mass="73427" checksum="ED77F6EFB93EE99D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0G3</accession>
    <name>A0A2I2G0G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_511150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701661.1">
        <property type="nucleotide sequence ID" value="XM_024854857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0G3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0G3"/>
    <dbReference type="GeneID" id="36562563"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511150"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF37">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="583" mass="65534" checksum="2A5B1ED02F4C549E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0G4</accession>
    <name>A0A2I2G0G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_477251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701673.1">
        <property type="nucleotide sequence ID" value="XM_024853432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0G4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0G4"/>
    <dbReference type="GeneID" id="36561130"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477251"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="433" mass="47962" checksum="06B515082D5E529E" modified="2018-02-28" version="1">MPSDSVDVSPLGQPLHLPFSKRTAPNRFYKAAMTERLSSWSPTDLAARGVPSPELINLYKCWGESGYGMISTGNIMIAYDHLEAAGNPVIDLENPYHGERFEAFQQLATEAKRHGSLVVAQVSHPGRQVIERIQPNPVSASDVKLEQTMGMTFGQPHAATIDEIQDIVRRWTHAAVYLHKAGYDGMQLHGAHGYLLAQFLSKTTNRRTDQYGGSLENRARLIAEIAQSVRRELPSSTGFILGIKMNSVEFQADGFTAEEARDVCKILEENEFDFVELSGGTYEASAFGPRRESTKRRESFFLDFASLITPALQQTKSYLTGGLRTAAGMVEALEAVDGVGIGRPATQELDLPRAILAGTKTRATEQKYDQYNFGLTSAVAGTQMKQAGKGQEPIDMSDETNVAGFMQQLKEWMQRMTQDAMKEMNLYGFMELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0T4</accession>
    <name>A0A2I2G0T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_477372</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701794.1">
        <property type="nucleotide sequence ID" value="XM_024853450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0T4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0T4"/>
    <dbReference type="GeneID" id="36561148"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477372"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="PA14" evidence="14">
        <location>
            <begin position="406"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB46492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="842" mass="91281" checksum="7F043178899557DC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1C6</accession>
    <name>A0A2I2G1C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_438395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701985.1">
        <property type="nucleotide sequence ID" value="XM_024849593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1C6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1C6"/>
    <dbReference type="GeneID" id="36557292"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438395"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF5">
        <property type="entry name" value="BOX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="322" mass="35183" checksum="5704B1AA29DBC62F" modified="2018-02-28" version="1">MSRKDESKAEKAKDAATVSVNVEDYTKTRDSVIISLAQLQSAVSDLSRAYINHTSTVLNPGSSNLDIGGITSGITNTLFESGLLGARPTSPGAKSEVGEKKKRKRAPPDPNAPKRALTPFFLYMQHNRAKIAEELGGSAKPKDVSDEGTRRWAVMDEPHKEIWKKLYADNLAIYKEKMKAYKAGVPVADDDSARAANQLQQDVEGVSGSGAEETDDDNDDDDEEQAQEQDDEEEEEESSPEPEPVKEPTPPRSSAKRRRSEGKTKEAPTPVPEKKESPEKKTKRTSARKAAEEPPASARKPAAADNKRGAKKNKRKSEAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G252</accession>
    <name>A0A2I2G252_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_477817</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702264.1">
        <property type="nucleotide sequence ID" value="XM_024853504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G252"/>
    <dbReference type="STRING" id="1392250.A0A2I2G252"/>
    <dbReference type="GeneID" id="36561202"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477817"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="104"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="608"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="846"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="860"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB46962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="967" mass="106717" checksum="C17EE4C692ACF1D3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2C6</accession>
    <name>A0A2I2G2C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_232462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024842900.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="36550599"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_232462"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="130" mass="14937" checksum="AD016D39FEA7D7FD" modified="2018-02-28" version="1">MATNERPRLGIASELSPHAALQYSVPLGNAESMDGSAALIGRPKKWVEEQVWTGENCWSDVTQLPLHVTESRHEVRGGKEEKEKERNNWILFWIVIFYLAPGQRIFSDRPLVFFGFYSQMHQKPELKAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2T4</accession>
    <name>A0A2I2G2T4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_428406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702496.1">
        <property type="nucleotide sequence ID" value="XM_024847838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2T4"/>
    <dbReference type="GeneID" id="36555537"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428406"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="332" mass="37888" checksum="F3A301E04D78B20E" modified="2018-02-28" version="1">MSVVVRYQEDDTMPMLAGVISQLLRAENIPCVLWGPGYRSLLAMEDSSHPHYRVDFVIEDENMNGAIRALRKAGFIEDGVGATCANCMHGPELEPEIIHQAIELGDSNYCFRANPHPITRSDYQSDHEFAAALKTLERRIGYTPRPSMYPHIGLFLKSQHMWTMPRFKLDIPREDDQCFMLASDIAFPGTKPLRRLRYSTAYGPVVTVNPVCFVKILILSVVRGAHLTGDVNFEESIPINLMRVADRVGPYFERDSHDILNYDRYSKRLRGIWMLINSIETKDKGMAAQFGKPATDDDEDALRKRILQVAKEMAEDFDFPETPTSWRFKPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3E9</accession>
    <name>A0A2I2G3E9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_439074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702704.1">
        <property type="nucleotide sequence ID" value="XM_024849755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3E9"/>
    <dbReference type="GeneID" id="36557454"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439074"/>
    <dbReference type="OrthoDB" id="4497487at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="328" mass="38351" checksum="D8433B4210B6C6CF" modified="2018-02-28" version="1">MYRTPYPTSSIDLPKPPIPYIPGWKFPVQSHIPPAPTLVTYEWYLSSKAERVERNQLSPLERCVRNPPLEGPEPREPPHTFELRIVHPIRIGDGHNSQVFVVKAGGTHPLPEDRTLVAKVYDPLYHDDESGFHSPFKCMNQHYTHEARAYEMMSEFQGHLVPRYYGSYTTEIPAGNSRVRTVRLILIEYVEGISLLQVHPNSFSQEIRQQIIKSVIDFDTTVMHRQNIVVRDLSPRNLMILETTALDPKKHLVFVDLAGALFNRRPDWPGLPKCKFLDQYISPLLRWRRSEPLEFGDWVDWDWKPWIEQEYAHTADTITQEMRDVYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G418</accession>
    <name>A0A2I2G418_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_409841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702928.1">
        <property type="nucleotide sequence ID" value="XM_024846815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G418"/>
    <dbReference type="STRING" id="1392250.A0A2I2G418"/>
    <dbReference type="GeneID" id="36554514"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409841"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="334" mass="35777" checksum="FD39617F40707E8E" modified="2018-02-28" version="1">MPSNLPFPPGIHVPSLTFFSPSPTQTLNLPLQEAHLNYLLSSPLHGIVLAGTNGEAATLTPSEKSHLIKLTRSIAHRLNRPKTPITVGTFGGSTHAIIDDAKSAAEAGADYVLVLVPGYFAFAMDDDAIVQFFEEVADNVPVPVVVYNFPGVVGGLNVSSQMLERLGEHRNIVAVKLTCGSIASVTRTAARFGSARRFIASSSGGGDGKGDEDVPGFVALAGQSDWLVPCLSVGGAGCITGLANLFPKTCVEIYNLYTSGQRDAAEQLQQKLAVAEWGFAKGGINGTKWVVGKYLGYDEEDCWCRRPYPKFVDEGKRDWIVRQVQGLKEIEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G440</accession>
    <name>A0A2I2G440_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_426873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702940.1">
        <property type="nucleotide sequence ID" value="XM_024847739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G440"/>
    <dbReference type="STRING" id="1392250.A0A2I2G440"/>
    <dbReference type="GeneID" id="36555438"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426873"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="323" mass="35612" checksum="5A6F7F299E39C903" modified="2018-02-28" version="1">MSNYNWDTTAEQVASDCRPSIMNKTILITGVTPGGLGAGFATIIAPYNPSLIILAARDTSKAKITAQEIENVARSVATRILELDLNSQTQIRKAAKEVLSYDEHIDVLVNNAGVMAPPFRLTEDGVESQFGINHVGHFLFTNLIMSKLIAPGKVSRVVNVSSDGHRMGPVRFDDWNFDDGNTYDPWLGYGQAKTANMLFSLSLAQKLGTRGLISVSLHPGVINTNLLKGDVDESVESLVKWDKALGNRPFWRGFKWKTMSQGVATHVFAAFHDDILTTARNGGFLLDSTGVPPEDIRCWARDSIEAERLWKLSERIVGERFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4Q9</accession>
    <name>A0A2I2G4Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic checkpoint regulator, MAD2B-interacting-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_360697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703163.1">
        <property type="nucleotide sequence ID" value="XM_024844426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4Q9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4Q9"/>
    <dbReference type="GeneID" id="36552126"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360697"/>
    <dbReference type="OrthoDB" id="2555634at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="45338" checksum="F8BADAA1B76C7741" modified="2018-02-28" version="1" fragment="single">QHSKPTMALVSYSDSENSDSEPETTPVSQPKTQKPTPAPAAPSAGGASFPSIVDRSNPRKIRVALPEIKSEKPNDQDGDDGPARKKPRIGGGGGLFSGFNSFLPAPKRNPAAEKEKNAKAASVRKVFSLKTGAAPGFDREADAEMRRDQAFDLVTGGGGENDDETIPKAGSLKTEEFGETQTNTEYKGEEGVKEKPVEVKLKGNPMMFKPLSVGRTQQKKKKAPATTTATTNTTSTTTSTTSSPAVDAPKEQAPPPPAAPKPKPKVSLFSLSSAEPDAAAPPAQTTSTTYEPLVYSAPSEAPTAGPTAPESELTSAGVATGPAETLDNIADDLNLSRAQRRQLFGRNADSSKSRVLHFNTDKEYIANQEMAHNTDLAAVQHNPVRPIAPGKHSLQQLVNAASNQREALEESFASGRRNKQEAGSKYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4R6</accession>
    <name>A0A2I2G4R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_360084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703145.1">
        <property type="nucleotide sequence ID" value="XM_024844399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4R6"/>
    <dbReference type="GeneID" id="36552099"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360084"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6971" checksum="D806F276C11BA662" modified="2018-02-28" version="1" fragment="single">QKNHLFRRTFKYSIEYNADISLVITLRHNRQIFFFNLNSLWSPLYKQLVCYFAGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5G0</accession>
    <name>A0A2I2G5G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_360373</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703420.1">
        <property type="nucleotide sequence ID" value="XM_024844409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5G0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5G0"/>
    <dbReference type="GeneID" id="36552109"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360373"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014136569" description="RING-type domain-containing protein" evidence="11">
        <location>
            <begin position="34"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB48118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="534" mass="58284" checksum="C6FD950FACF8AE44" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G628</accession>
    <name>A0A2I2G628_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_411083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703627.1">
        <property type="nucleotide sequence ID" value="XM_024846872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G628"/>
    <dbReference type="STRING" id="1392250.A0A2I2G628"/>
    <dbReference type="GeneID" id="36554571"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411083"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="452"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="554" mass="61166" checksum="BEE04C7BD7B03DE8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6M5</accession>
    <name>A0A2I2G6M5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_387042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703833.1">
        <property type="nucleotide sequence ID" value="XM_024845793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6M5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6M5"/>
    <dbReference type="GeneID" id="36553492"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_387042"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF41">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="527" mass="57632" checksum="231CFE473DCEE8DA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6R7</accession>
    <name>A0A2I2G6R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_321583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 8">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703868.1">
        <property type="nucleotide sequence ID" value="XM_024843314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6R7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6R7"/>
    <dbReference type="GeneID" id="36551014"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_321583"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000014">
        <property type="entry name" value="Translation machinery-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="10">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB48566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="191" mass="21124" checksum="58A52A036DDFDCFD" modified="2018-02-28" version="1" fragment="single">MAEILQPTPAEFQAKHVVYCGVCTLPAEYCEFGGTAKKCEEWVKDNHPDVYQQLYSEEALSSNLSNLSVSVRERAAKDAAKKEAKAALAEARDAERKAASKVHIKRVERNKRKHVSVITGLEVYGLENKKVAKELGKKFATGSSVTKSAAGTEEITVQGDVSDDVKDWLLEVYGKEIPEANIEIIEDKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6X4</accession>
    <name>A0A2I2G6X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_407288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703926.1">
        <property type="nucleotide sequence ID" value="XM_024846672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6X4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6X4"/>
    <dbReference type="GeneID" id="36554371"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407288"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="619" mass="67022" checksum="CACA35A0D4D9476C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6Y6</accession>
    <name>A0A2I2G6Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_474991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703940.1">
        <property type="nucleotide sequence ID" value="XM_024853207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6Y6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6Y6"/>
    <dbReference type="GeneID" id="36560905"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474991"/>
    <dbReference type="OrthoDB" id="4138941at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="194" mass="22395" checksum="369C428B7A787A54" modified="2018-02-28" version="1">MENRRAVDQMSIENQVFARAERMDFRDHCAERFELQADGVEELLSCSLNESQNLELIVLKVMHRPDEFGIPSLSSVFPFLEAMCPKEDPAWCIHSARQLDLYDAAWVMSDKKQNSTPEANLSMVSFRGRIFLDVEHIVRNRDSFFVLVLIPRSWVVEDINDLVIRVSSRFTETEKPVGTTVSREQAESILNDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G727</accession>
    <name>A0A2I2G727_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_356750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703988.1">
        <property type="nucleotide sequence ID" value="XM_024844174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G727"/>
    <dbReference type="STRING" id="1392250.A0A2I2G727"/>
    <dbReference type="GeneID" id="36551874"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356750"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="266" mass="29659" checksum="941CD9D0AD6EE5A9" modified="2018-02-28" version="1">MAAEPDLEALTVSFEKATIQENSAVFVDTKKDVADLVGVLEKLPVSPPSLYVDLEGANLSRHGSVSVIQMFVLPLNKTYVIDVHKLKQKAFTQASLTGCTLKEILESSSIPKVFFDVRSDSDALYGHFGIKLAGIQDLQLMELATRSFSKKLVHGLAKCIERDVPMTDSEKNSWKVGKEKGRKLFSPAQGGSFEVWNDRPLSGEIMQYCVQDVQFLARLWLEYSRRLTSLWAPKVEAEVRQRIVDSQSTDFIEKGMCRTLGPAGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G796</accession>
    <name>A0A2I2G796_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_509462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704037.1">
        <property type="nucleotide sequence ID" value="XM_024854682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G796"/>
    <dbReference type="STRING" id="1392250.A0A2I2G796"/>
    <dbReference type="GeneID" id="36562388"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509462"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="116" mass="13654" checksum="A2778CC203C8DF31" modified="2018-02-28" version="1">MTTRMNHKFTYPELNYDAPVNFQPCTKLTIFFHKPDDLSPGQFSDHWAHFHADILLAMPLFRKLGLRYSQYHQSPEMKARFKSTGLEGINLLEHDGYAELWFRTWMTGLLFRKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7X7</accession>
    <name>A0A2I2G7X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_358566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704289.1">
        <property type="nucleotide sequence ID" value="XM_024844303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7X7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7X7"/>
    <dbReference type="GeneID" id="36552003"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358566"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="470" mass="51749" checksum="7B7884B23E23D024" modified="2018-02-28" version="1">MTRNIKAELNARLSASNVIVAGDDAWEDTLERWTKYRFQVPAAVIQPTNEDDVIEAVSYAVQNNRPFVVRGGGHSNGFSTISSPGVVIDLSRMRNVRVDVDNLLVTAQGGATMGDGIQVAGKAGLAIATGTCNEVGLVGATLGGGIGRFLGLWGYAIDTVVSMRVVVVDQSGTARAVEASREINPDLFWGLRGSGHLFGVVVEATFRAQPWHHDTWHSCLVFSPADAGMAAEAMDRIHYSGGMQGRFVFCAPNKQPVVLLQLWYVGSPDEAASKFDSLLSLPSMKEHPMNFVGHLIPYLNLNDSSDRVCGYAGRKNLAAFGMKSMSAEACDAALKVYMDFIHEHPEAAQTHILTEFYSMDVAKELDPYGQETSMSRDARQDVKYWVMPLAWYENASLDEDCARLNRDIREAFLREPDGKRANCVAYVNMPFEDDTARSVFGKREREGKLRELKTKWDPLGVIHGLIKFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G873</accession>
    <name>A0A2I2G873_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_509710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704367.1">
        <property type="nucleotide sequence ID" value="XM_024854702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G873"/>
    <dbReference type="STRING" id="1392250.A0A2I2G873"/>
    <dbReference type="GeneID" id="36562408"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509710"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="11"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="327" mass="36225" checksum="2CF6839BC7B48937" modified="2018-02-28" version="1">MGSLTDSPLTFKPLHPTFGAECHGVDFSSPLPPSTISSIKAGMAKYGVLVFRATQLDDAGHVAFASQLGELDDSTPFIQPGQKYRLHPFTQLTDVGNIEADGHVVPTTSLRHQMGLGNGLFHVDCAYNPRRAGLSLLRAHQLPPKGTGGGTAFADTRTAYEDLDETTKAQIDEYVLCHSLWQSRRLGAPDCDFLKQMNPEDHFMARHRLVQTHEPSGRTNLYIAWHAHHIDGWGREESQPVIERLLEHASQEKYTFQVDWENNGDLVIWDNTCVMHRACGGSFAGRYVRDMRRATVHDSSSTAWGLNEKTDNRAGMFGAGMPKPTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8W9</accession>
    <name>A0A2I2G8W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saponin hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_408469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704626.1">
        <property type="nucleotide sequence ID" value="XM_024846733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8W9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8W9"/>
    <dbReference type="GeneID" id="36554432"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408469"/>
    <dbReference type="OrthoDB" id="10265322at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014175287" evidence="2">
        <location>
            <begin position="20"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="608" mass="65978" checksum="7DE5C20AFB455985" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9I0</accession>
    <name>A0A2I2G9I0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_185319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704805.1">
        <property type="nucleotide sequence ID" value="XM_024842690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9I0"/>
    <dbReference type="GeneID" id="36550388"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_185319"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="144" mass="16176" checksum="F23752EE632456D5" modified="2018-02-28" version="1">MRVRTRSTALDGVRRTLLHIPIIFITLLIISGSCPPDGLHEDVGRICDRSQRWSSRPRGMAEMNQRSFHSGDVAEGNRVGQRFQTISLVFPPFTQPNYWAEIRVTTRGDPRSGSPQGCQLSRSGVCHSLRTHELPSLLNPWNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA48</accession>
    <name>A0A2I2GA48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_437272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705056.1">
        <property type="nucleotide sequence ID" value="XM_024849326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA48"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA48"/>
    <dbReference type="GeneID" id="36557025"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437272"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="78"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="504" mass="57771" checksum="48F85E83D12E9EAB" modified="2018-02-28" version="1">MPTLPTSIESFSPPLNLSPERVIEGGQWKPQLAQRIQPRHGMSSFSWMARFLPSVFTGPTNGDTNTIEKQRQRTRPTAYLDGLRGFAALLVYWAHHELWAHDGVGAGKAFELAYGYDNKYYFACLPGVRTLFAGGHFAVSVFFVLSGYVLSMKPLGCIQDGDYAELGKSLSSAVFRRWFRLYIPVICTTLSYMTFMHFFKIRTITELQGSYLSELWNWYAEFKNFSFVLRTGGEPWFTYNMHTWSIPVEYRGSLAVYTAAIAFARFRRNARLIGQVALVVYFLYIADGAHFAMFIAGMLLRDLDLLAMRNDLPSFFHSLEPFKSAIMTFLFYVSLYLGGVPSHTDNVQQLRDSPGWYLLSFLKPQAVFDYKWFYLFWAAVFLVSCTSHLPWLKAFFAAPFNQYLGRISFAFYLVHGPVLWILGDRLYAAVGFALDSHAQNCPWWINRFPLPTRGPFGLEVNFLIPQLVLLPLTLWLAEVTTRLVDDPAVKLSQRMYQEGLVDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA73</accession>
    <name>A0A2I2GA73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RelA/SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_510241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705073.1">
        <property type="nucleotide sequence ID" value="XM_024854755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA73"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA73"/>
    <dbReference type="GeneID" id="36562461"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510241"/>
    <dbReference type="OrthoDB" id="4719016at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773">
        <property type="entry name" value="GTP PYROPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773:SF1">
        <property type="entry name" value="RELA_SPOT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA/SpoT" evidence="1">
        <location>
            <begin position="91"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="726" mass="82758" checksum="2F0392642F587E84" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAL0</accession>
    <name>A0A2I2GAL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 5-oxo-L-prolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_463270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705216.1">
        <property type="nucleotide sequence ID" value="XM_024852159.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GAL0"/>
    <dbReference type="GeneID" id="36559857"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463270"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="543"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="739"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1281" mass="138267" checksum="D6B15073FD0C4FC5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAR5</accession>
    <name>A0A2I2GAR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trihydroxytoluene oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_354853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705267.1">
        <property type="nucleotide sequence ID" value="XM_024844062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAR5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAR5"/>
    <dbReference type="GeneID" id="36551762"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354853"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="195"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="355" mass="39927" checksum="B95E1D289EA7872D" modified="2018-02-28" version="1">MSPPTISASRGGTLPDTEAMGKDQESQSSWLQKRSISAETRINLKKLSHVRYQHPNLDEIHQFMLDFGLQVAHQTAEHIWYRGYGPDHYVYYAQKGPRKFLGGAFEAASLEDFERATALPNAGPVQELADAPGAGSLVTITDLEGFPINVIYNQEPINPSREQSPREKIVLNFPSEKPRVRQFNRFEPGPAAVYKLGHFGLSTQDFESQLQFYTSTFNIVPTDFVYIEQNGQRIPVTVFMHLDLGMEPVDHHAFFLGANPKTSRIHHCSFEVHDYDTQQLGHQWLVEKGYQPAWGVGRHVLGSQIFDYWWDVSGNMVEHYADGDLVNADTPIGYVPAGPDSLAIWGPKVPAAFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBD8</accession>
    <name>A0A2I2GBD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_435397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705500.1">
        <property type="nucleotide sequence ID" value="XM_024848925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBD8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBD8"/>
    <dbReference type="GeneID" id="36556624"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435397"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="154" mass="17698" checksum="40F6FFD8BBA37195" modified="2018-02-28" version="1">MLIPKDDRKKIHEYLFREGVLVAKKDFNLPKHGDIDTKNLYVIKALQSLNSRGFVKTQFSWQYYYYTLTPEGLDYLREWLHLPAEVVPATHIKQQRSHAPPRGMMGGEERERRPRAPREGGYRRREEGKEGGAPGEFAPSFRGGFGRGRGAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBH0</accession>
    <name>A0A2I2GBH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NGG1 interacting factor Nif3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_380707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705525.1">
        <property type="nucleotide sequence ID" value="XM_024845540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBH0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBH0"/>
    <dbReference type="GeneID" id="36553239"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_380707"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000008">
        <property type="entry name" value="NGG1 interacting factor Nif3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="379" mass="40394" checksum="D4922C952628DB81" modified="2018-02-28" version="1">MNPLFSRLPRLYSTMAASFPASSSPYTRAVVSSMRKLYPESLAEKSFDNTGLLLEAPFNHERRQRNSVLLAIDLTKAVADEAIARKDSVVVAYHPIIFRGLKSLTLNDSQQQSLLRLAQAGISVYSPHTAVDATPGGMADWLCDIVTGAIAPSTDSTPAIQKSSSTQYSQPAFPQPGTVRPASAEPHVRTTIHPSPPPVPEGMESAGMGRLVTFDTPQPLTAVVDRIAQGTGHPGGIPIAIPQSASVDTMKIRTVGVCPGSGSSVLLKAPGGIPDLLFTGELSHHEALAAVERGSVVVALAHSNTERGYLHAVMREKLADAVQKEWEVTRSEGLRTLGDGSQDGTGVVDALQKAYGDAESFVDVSERDRDPYGIMIRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC43</accession>
    <name>A0A2I2GC43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_144292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705748.1">
        <property type="nucleotide sequence ID" value="XM_024842491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC43"/>
    <dbReference type="GeneID" id="36550188"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_144292"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="178" mass="20170" checksum="FFAAC35830BA8A46" modified="2018-02-28" version="1">MRTRIVRSVVQRRQRFESKDSNPGVLQTNGYDRQAALMHDDVGGGHRFSLWADARGPNRQCGAVCTEDLGERRLFCTQEVFRRWFNLVFNPPRLASRRLARCEAYPSSVGAWTPRFFLLFSPFCCRVRGEQGGRGVGRKAGQRSPDRQEQGRPKEEVGMDGAMTRGGEMEWWGGSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC78</accession>
    <name>A0A2I2GC78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ypt/Rab-specific GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_445778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705785.1">
        <property type="nucleotide sequence ID" value="XM_024850738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC78"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC78"/>
    <dbReference type="GeneID" id="36558437"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445778"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="254"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="576" mass="65120" checksum="8B82DA2CA20104D9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCE4</accession>
    <name>A0A2I2GCE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Secretion related GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_354757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705819.1">
        <property type="nucleotide sequence ID" value="XM_024844057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCE4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCE4"/>
    <dbReference type="GeneID" id="36551757"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354757"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB50517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="206" mass="22888" checksum="AF8BD148467A9A7E" modified="2018-02-28" version="1">MAGTRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFQNIRTWFSNVEQHASEGVHKILIGNKCDWEEKRAVSTEQGQQLADELGIPFLEVSAKNNINIEKAFYDLASEIKKGMDTSKAEQAGPQGVNIDQQGSGLNGNTGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCV5</accession>
    <name>A0A2I2GCV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_455167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706015.1">
        <property type="nucleotide sequence ID" value="XM_024851507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCV5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCV5"/>
    <dbReference type="GeneID" id="36559206"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455167"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56883" checksum="759F8183033D3058" modified="2018-02-28" version="1">MAILKDLYQRFLGGPRPAAMAPDVSVSYITTTTKFEGADAVLSHLTKQDNVVKRKSEQVIAGIEGDNSVCVDVETTLEFVSGGGAYLPSMDDNFLADRVATFPTLHIVHFNSQNQIQQIRIYWDQASLLKQVEVIGARGRGWPIREAKEQTRFIKSAASAAAAPKRRANQSNDEPENGDERSKRASPGKKHIKDPHAAGSLYELLSPEKDRAEPVRAPRAPASAKPPPREYSELFVGADDNADDEDAPDATPSKPTKFAPKAGAGKNFRASRIFDDDETVAAEDSHRQIAYRANPKRFDHFEIGGDNSRREIQEVPSRPGSRHVPHWEFDDFATPEKPKRQPRGEEIRHFGWSDDEPEPTPVFQKHVSQPRRDAETHFSMTDQDEETSGPRYIRAYGNKGMSLYKNHLFDDAAEEKSNENAPLSSAHNGPNRREFESHWTAADESPADGKSNENKKPVGADRQKALKNMESQWEAYDESPQPSKFVRPPPQRRAIRKVNERSWGLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD25</accession>
    <name>A0A2I2GD25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_492869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706072.1">
        <property type="nucleotide sequence ID" value="XM_024854033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD25"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD25"/>
    <dbReference type="GeneID" id="36561737"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_492869"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="30465" checksum="749B8FC83D3945BF" modified="2018-02-28" version="1">MTPQQPTVLITGCSDHGIGSALAHVFHARGYHVFATARNPSKMKTLANLNNVTLLTLDVRDSTQIARAVDAVRAQTGGSLTYLINNAGRNHFMPVLDEDLDAGRELFETNVWGQVAVTKGFVPLLLNSGGDGAVVFTTSISGYLNVPYMGTYAASKRSLELIAETLRLELAPFGVRVLSIVTGAVQTMGQTYFGDFKLPDNSLYKSIEGTIAARARGEDGRGRGDLMAYAEEVVSAIESGAEGRVWCGENAESTRLATTNPAVPAEVMDRGVAQGTGLDVLSGQLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEC8</accession>
    <name>A0A2I2GEC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_436268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706489.1">
        <property type="nucleotide sequence ID" value="XM_024849123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEC8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEC8"/>
    <dbReference type="GeneID" id="36556822"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436268"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB51187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="482" mass="54523" checksum="D0C7BA1B95BF6B18" modified="2018-02-28" version="1">MSSRAEVKYEFGGPLGASAITFGLPVLLYIFAFACNDVSGCPAPSLLSPRTLSWEKLSAEIGWPPGGLRDLGSWEATGVVLAYYLFSLILWRVLPVHITHGTKLVHHGRPLEYRFNAFSSTIVHLVICAVGTYLRGADFVVWTYISDNYVQILTANIFIAYALAIFVYLRNFSVSTNYPNDDMRELAAGGQTRNHIYDFYIGRELNPRVKLPVFGEIDIKTWCEMRPGLTGWLLLNLAFVAKQYRTYGYLSDSIILTACVQGFYVLDGQYFEPGILTMMDITTDGFGFMLAFGDAPWVPFLYSTQCRYLSVHPVHLGWTGVGGVISVFLLGLYLFRAANSQKNVFRANPDDPRVKGFSYIQTKRGTRLLTAGWWGMSRHINYFGDWLQALPFSLPTGLSGYAIVPAGSVAASHVFKMLDGREVVQDQAAGWGVFFTYFYVLYFAILLIHRERRDDAMCLEKYGADWEKYRKLVKWRIVPWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFB4</accession>
    <name>A0A2I2GFB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_443758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706871.1">
        <property type="nucleotide sequence ID" value="XM_024850581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFB4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFB4"/>
    <dbReference type="GeneID" id="36558280"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443758"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="310" mass="34409" checksum="3358452505C4DF61" modified="2018-02-28" version="1">MASSRNLGTAVLAVAWTFNGLATMVIAVRYYVRSKIIKKLTVDDGLILFALGLGLGNSICLTISASHGLGSHVNELYADQIMYSIKWVYICEFFSILSPCIGRIAYAFLLLSLVPPIPWRSRLLWSIICLQFVIDCGTVVVSFAQCTPMRRYWDHSVPGSCWPPNVQRNTGYFQSSVCCAVDFVLAIFPASMFWKLNMEWKKKFSLSFLMGLGIFAMIASVVKTIQLRAIAVTDDQTHAMANLAIWWTLEAYLVILAASIPTLRPIVTAPRHASSVGLHAVGSSFLPRGHNAGLDSISEFQLLDRDHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFC5</accession>
    <name>A0A2I2GFC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_376149</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706888.1">
        <property type="nucleotide sequence ID" value="XM_024845352.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GFC5"/>
    <dbReference type="GeneID" id="36553052"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376149"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.20:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="577"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="1276"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1187"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1538" mass="170497" checksum="93851C028D0FA4C3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFE1</accession>
    <name>A0A2I2GFE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_349784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706905.1">
        <property type="nucleotide sequence ID" value="XM_024843759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFE1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFE1"/>
    <dbReference type="GeneID" id="36551459"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349784"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="328" mass="36927" checksum="E8B37E3E941DF5F9" modified="2018-02-28" version="1">MEDVFLQEDLSPTIAEHATQCQSLFHKCIVIPEIVPDPTIMDDQLARFALWASNMDVYGPPNVSLDYRLRFSPVAADIIHQLLDIIYDTLLSLNGNSGFTRRSDDDTSDSESDIDPAEENMLKITETIGGTLTRLFRLSNAVRKSAKTNRARKIERYRDDEEANKAIDELRLYTKCYIEFRFPEAPEALRSALVEANALRLRRLYYQRSHRRRIDLSIQIPEPTPAVVQLPKMTVNAPAVRFAPSALPKPARTNTMLAPVPAPATNATTARQTAVAEFYAKSTTEIPRAKSVLVNDKLPFPPIPPTPQCPYCGVIVEFKNSARSLLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFH0</accession>
    <name>A0A2I2GFH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_400969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706930.1">
        <property type="nucleotide sequence ID" value="XM_024846354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFH0"/>
    <dbReference type="GeneID" id="36554053"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400969"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF3">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="163"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="376" mass="41521" checksum="A067A3807ABF852F" modified="2018-02-28" version="1">MSEKSSLVSLHQEVDQGTLCRIKARLAHIMQLWSAGKPFFPRALLEDLNRQIDAGQDEVYITDLDDVRQKYSLTVPKWCADFANTYRINYSSIQHLGHLTPIYPELALRNDHTPVSIVYARSMPSPGQCTLEQVQARFTHTRTLWLGSSTRRDLERIVSTLPLSAPITKIVCFALGSLAPLDDSDSEGSISTSLSNSILDTSSTSTLNASPVRCTFTRHVTRAHAQHAAVETMLTALRSRGMLAPGAQCIAQDPAYDAVDCAFLSSIGIRVVDDPKGFLEVDATTLVLSVSPNVPVKQILADVQWPAAMVWNTVALVEKESEGWVKNVEENGEVQWSSPFTTDPDCARVRDMIKGYARATLDDGNDFFGDITVYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFH4</accession>
    <name>A0A2I2GFH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_422623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706935.1">
        <property type="nucleotide sequence ID" value="XM_024847451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFH4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFH4"/>
    <dbReference type="GeneID" id="36555150"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422623"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="152"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="453" mass="49577" checksum="B425343B32C7FB7F" modified="2018-02-28" version="1">MATPEDTLSIAIIGSGIIGTVLALGLLNHPSASSDTSPKPKLKVKVYEQASSIREIGAGIAFTANARKCMSMIDARLPECVRSVATANGDPANPTNYMQFVDGYTHAAGDGVGEEMEGRTVHRLHAGERGFEGCHRAQFLEKVMELMPGGVVELRKRLVSLDQEDGDKVKMRFEDGSQEVADAVIGCDGIKSLVRQHLLGPSSPSSYPHYTHKIAYRGLVPMPLAMQTLGPYRATNQHMYGGPSAHLLHFPVMQQKLMNVVAFVSDASDWPLDKAMSQPATREEAAVAFKDWGPTVKAIINLLPDEMDKWAVFDHLEFPTEKYSEGRVCLAGDAAHASSPHHGAGAGIGIEDALALRTLVGFVLDDLKEGGGGEGKKKDLLTKAFQTFSKVRHERSMWLVQSSREACEIYEWNHPEFGSDMGAAHEDIRRRTHKIWYFDIEGMMGELEGGYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFS3</accession>
    <name>A0A2I2GFS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_461882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707031.1">
        <property type="nucleotide sequence ID" value="XM_024852071.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GFS3"/>
    <dbReference type="GeneID" id="36559769"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461882"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="705"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1437" mass="155707" checksum="4BBE6E10739BDAD1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFW4</accession>
    <name>A0A2I2GFW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_401282</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707078.1">
        <property type="nucleotide sequence ID" value="XM_024846365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFW4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFW4"/>
    <dbReference type="GeneID" id="36554064"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401282"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="378"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB51776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="551" mass="61628" checksum="4254E2AA95E9EB6D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGM6</accession>
    <name>A0A2I2GGM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_462108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707337.1">
        <property type="nucleotide sequence ID" value="XM_024852080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGM6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGM6"/>
    <dbReference type="GeneID" id="36559778"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462108"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="294" mass="33245" checksum="824C17812CA33184" modified="2018-02-28" version="1">MSERKVLSKYYPPDFDPSAITRTPKHLRSTGPKVITVRLMAPFSMKCTHCGEYIYRGRKFNARKETTEEKYFSIPIYRFYIRCTRCSGEITFVTDPKNMDYRAEKGAKRNFEPWRDASAAAGTYNETEQETLDRLEKEEGEEQEQQERDKMAELEEKMHDSKREMAIADALDEIRTRNARIARTEGLGEDVALGQVRGEVDENREREEREDEEAARRAFTTETGEKVKRLVEEEEDAQEGPSTGVGSGAGAGPSADAKPTGAMPPPPSFARTKKPKKPLVNGLGIKKKAKPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGS9</accession>
    <name>A0A2I2GGS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_471998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707391.1">
        <property type="nucleotide sequence ID" value="XM_024852894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGS9"/>
    <dbReference type="GeneID" id="36560592"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471998"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="496" mass="55489" checksum="8955F44F2D524FE7" modified="2018-02-28" version="1">MSTEDAFKMTKKPIDRDESKALDVLREGEIENVNGRKLLWKLDLYLLPLLCITYALQSIDKTTLSYAAVFGLEDDLHLKGTEYSWLGAIFYLGYLVWEFPTNVMLQKFPINHFMSATGIIWGIVLMCHGAATNFGGEAAARFFLGVFEASINPGTMLLFSMYYERHEQPLRMGIWIGSAGLGYVIAGIASFGIGHIESAIASWRLLYIIWGAITTAWGLVLLTFLPGSPLTAKFLTEDERALVVERIKGNGTGLDNRKFKWSQFFEAMLDLKTWLLFLFAVTSNSPNGGLTSFQGLIIKGMGFSTLKTTLIQMPSGGVQLIICPLACFFASHYPNARIPTMLLCIIPFLVGVLGLWLIDESKPYGRLICLWISFTYVAAWTLSMSVATANTAGHTKKITTNAMLLIGYCLGNFVGPFFFKAEQAPDYRLGAGMMFFCIAVQVVCLFSIWGLLWWRNRSRIGVMEGGMEGSRRDDLPEERGLMDETDMENKSFKYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGV4</accession>
    <name>A0A2I2GGV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_453612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707413.1">
        <property type="nucleotide sequence ID" value="XM_024851372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGV4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGV4"/>
    <dbReference type="GeneID" id="36559071"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453612"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="144"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="310"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="414"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="569"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="742"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="825" mass="91857" checksum="F8A5B372A4B6CE44" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGX1</accession>
    <name>A0A2I2GGX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_433978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707436.1">
        <property type="nucleotide sequence ID" value="XM_024848620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGX1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGX1"/>
    <dbReference type="GeneID" id="36556319"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433978"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="274" mass="30261" checksum="5FAE077C351E5676" modified="2018-02-28" version="1">MLIIGLTGSIATGKSTVSSFLSSPPYSIPIIDTDLLARQVVEPGTPGYKAIVEYFGPSTPDLLLPSKPDNPTPNPHGQPLNRPALGRRVFGTTDERKRDRLVLNKIVHPAVRWEVYKALVYYFVRGHWAVVLDVPLLFESGMDLLCGTVVVVGVRDAEVQMARLRARDPHLSAEEAQGRVSSQGDVRGKVEKAEFRGTENARGVIVWNDGDKEDLGKEVKKAMGEIQATSPKWWAWVLLLAPPVGVGVAAWNMAVNFMQQKSWEKKAREEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGX7</accession>
    <name>A0A2I2GGX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_506991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707425.1">
        <property type="nucleotide sequence ID" value="XM_024854434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGX7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGX7"/>
    <dbReference type="GeneID" id="36562140"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506991"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="122" mass="14136" checksum="0B08CB683C41866A" modified="2018-02-28" version="1">MCKHILNAQVAIRSPCCKKWFDCAECHLEQETHMLAKSVEMVFACKKCKKCFRKDAAEFEESDEYCPHCDNHFVIEAVTPKPSLQVEGEDARKDSRMLKDERVRGHEERSLFNIKDGTDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI16</accession>
    <name>A0A2I2GI16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_462441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707823.1">
        <property type="nucleotide sequence ID" value="XM_024852099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI16"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI16"/>
    <dbReference type="GeneID" id="36559797"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462441"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="465" mass="51309" checksum="E7A4EAF67AC8FB83" modified="2018-02-28" version="1">MATFDPFLLTPLDHYLVVGGIGAYGCNYFTFQTPDADAALEALQTGAARLIRELPFLGGEVAPRENDPRHQLEVRPSGPDRFESHPMVTARRIDAPLPAVSEIGHAIDADGDGVFRPLPSKGPEEFKPVLRLQANMYHGGIILCFCWNHLLIDGSAVSNIMQAFARCCREGDAVSLVEDRRQNELARDLIFDIINRPVPEGYQPLKDIEMHELAPFSTEDICRETLLLSPDRVEELKSACNNHLASSSSSGEQGSYCATNDIVMALLWIATARASLPQDKRCYSMNFCVSMGKRAQPAIPASYMGSTLFLTGVEISRDELADALAAIDASSTSTDTLPTAYIPLLSTLAARIRAKIVASDDAHLTKTVHELHKIPEWDAKPGKLGDILFSNLSFNTCFQHDFGAQLGRIVEFEPRTVYPSIGFLKPRRLVAGGLAPWEMTVMFERERMEVVKKDGLLGWVRGDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIH0</accession>
    <name>A0A2I2GIH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_403084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707978.1">
        <property type="nucleotide sequence ID" value="XM_024846459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIH0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIH0"/>
    <dbReference type="GeneID" id="36554158"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403084"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF4">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="179"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="475" mass="53351" checksum="7C55DA821137C469" modified="2018-02-28" version="1">MDTTGQPMAVREEGQPHMLPFHAATARPKPTEHGAPPSTTDGIPYPHFTLIYIDRNGETQVQSSPSVMEYEPAIFTPDVRERFVRAAARLTWQPGMPGFQSAEGHMEGDVTGRTQSFPSTNNSFMSLHHGSGFYQYGLIPFEWQSIQNRRHRRSLRRVDSGIGPNSPSPGPTITWTPLRIGNKDLLRRYYEMAFENFQQLNCRAIAKAFVKLVEPRKQVNHPYNGRSTAAGMSQRVDPELTKPQWWPEGVRHREPDHLLKSERIRLLVHILCELRDSHKITSEKLKDAGQDVRRGIVPEERLQVLDEIYYVRDMEELYLDGKIDGDTVIHVSQVQMPEANLTMQPNQQVTGDNIGDQPVPMIAVSSSHDTVPNTGHLPPGQSQSQGSSVILTPNTSPSVSRRSSLESNMTSYSHNMTPPGLAVNEPMRAVQPSETPSMTDYYDQQMAHQPAGQSSQNGLWSQLPHTHQPLGFQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIJ6</accession>
    <name>A0A2I2GIJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_348936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708007.1">
        <property type="nucleotide sequence ID" value="XM_024843708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIJ6"/>
    <dbReference type="GeneID" id="36551408"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348936"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="295" mass="33135" checksum="90FD0A9AC96F594D" modified="2018-02-28" version="1">MSSDDQSTGIDFALYRYTPSLAAGILFLVLFLLTTVYHVYQVICMRSSYMLVFVTGGVFQIIGYICRILAHYDKESIPVYSVGTIMILLAPPLYAASIYMTLGRLIRHLDAESISVVPTRWLTGIFLTGDIVAFVMQAAGGGIMASGTISAMHTGEKITIVGLCIQLLFFSVFIITSTIFHWRIYKQPTRMSLEGARKNWKQTSWETIMVVLYASSILILIRSIFRLIEYAQGNDGYLISHEVFMYVFDAMLMFFTMVVMSIYHPSQLLGKRAKAAQLSCDSRETSAEMQSMESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIW4</accession>
    <name>A0A2I2GIW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD binding Rossmann fold oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708122.1">
        <property type="nucleotide sequence ID" value="XM_024848737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIW4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIW4"/>
    <dbReference type="GeneID" id="36556436"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434541"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="559" mass="62587" checksum="0C37F67B88AA63FA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIX2</accession>
    <name>A0A2I2GIX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_472709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708121.1">
        <property type="nucleotide sequence ID" value="XM_024852973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIX2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIX2"/>
    <dbReference type="GeneID" id="36560671"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472709"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="556" mass="57894" checksum="0D15980B710AB917" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ04</accession>
    <name>A0A2I2GJ04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_434588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708165.1">
        <property type="nucleotide sequence ID" value="XM_024848747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ04"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ04"/>
    <dbReference type="GeneID" id="36556446"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434588"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="324" mass="35344" checksum="D8ADF48A4F0EFA60" modified="2018-02-28" version="1">MTQPSTITQRFLSKPSHLGVVAVGFNGGQCQSGVEAAPQALIEAGLLDQLRDDLGYELHYDQTVHYYEKNIPASDPDHRGMKKPRAVSAVTETLSSQVYEHAKDGKFVLTLGGDHSIAVGTISGTAKAVRERLGREMAVIWVDAHADINVPEMSPSGNIHGMPMAFLTRLAREEQKDIFGWLKDEHIISTRKLVYIGLRDVDRGEKQLLREHGIKAFSMHDVDRYGIGRVVEMALAHVGNDTPIHLSFDVDALDPQWAPSTGTPVRGGLTLREGDFICECVHETGNLVAMDLVEVNPSLESVGASETIRTGCSLVRSALGDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJF7</accession>
    <name>A0A2I2GJF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinone/menaquinone biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_434735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708314.1">
        <property type="nucleotide sequence ID" value="XM_024848782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJF7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJF7"/>
    <dbReference type="GeneID" id="36556481"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434735"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="330" mass="36675" checksum="6996C4CAD5A7F755" modified="2018-02-28" version="1">MSASRAGRAALKRAKAPITGAPRTGGKIPVERPGPKTPGASSLPNRANPHLLNLKPDDETRMSPRVMTALGVGVLGISAYCGYLFASYKREVAQSQSLDIPRDVSDRYNHTAGTFDADVEMSEKLMRMGSKRKSLVQRARGDVLEVSCGTGRNLEYYKLGEKRGLDEKDRVGMRGCRSVTFVDLSPQMVDITRQKFAKLHPAFQDVVFRAQDAADVPPPPTQGKPAYYDTVVQTMGLCSMPDPVGTLRHLGTIVEPRKGEILLLEHGRSHYDWLNRVLDNLAPAHADRHGCWWNRDIGQIVRESGLEVVEEQRWHFGTTWKYVLRPATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJV2</accession>
    <name>A0A2I2GJV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA exonuclease Rex3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_454309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708454.1">
        <property type="nucleotide sequence ID" value="XM_024851419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJV2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJV2"/>
    <dbReference type="GeneID" id="36559118"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454309"/>
    <dbReference type="OrthoDB" id="3996471at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF112">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="423"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="630" mass="68270" checksum="47A7246CC9D378D3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJW2</accession>
    <name>A0A2I2GJW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhyH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_454316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708464.1">
        <property type="nucleotide sequence ID" value="XM_024851421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJW2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJW2"/>
    <dbReference type="GeneID" id="36559120"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454316"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF51">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="275" mass="30976" checksum="44439271AA0E19AE" modified="2018-02-28" version="1">MENNHYPLTEDQIQFFQEKGYLLIRGFLSSPETARLQQWTREVHDLPRTPNASYMPYEEVNSQGQRVLCRTENYANSHAGFDSFLRGQRILSVLGQLAAEEMLLFKEKINYKLAGSGGFSPHIDANAYTHVKNIKHLTVLAAVDGMSSENGGLDVVDGSHLMSIPLGEDRCIDPTWVDSHQWSACDLKPGDILVFGSYLAHRSGANTSSQDRRAIYATYNCKAEGDLHDQYYEDRRKLWPATHMRKAGESYEEGRMRYGYGSPMLTIEGEAQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKE6</accession>
    <name>A0A2I2GKE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_473210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708643.1">
        <property type="nucleotide sequence ID" value="XM_024853019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKE6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKE6"/>
    <dbReference type="GeneID" id="36560717"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473210"/>
    <dbReference type="OrthoDB" id="10473939at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="176" mass="20912" checksum="84449BDEA119C840" modified="2018-02-28" version="1">MEALGSHQLRENFRMLGNVINDIKGKLWGYDVKGLNARVNNRLKEKDLSGAFNIVRAGISVFNYLNMPNVWKRYKQTNILVRQELERIQKAYKAASSKDAKLLECWDLFLYERMKGMTREPRQFVEDYLTKFKEEWVESKWPGDKDWLAQLQQVQSFVKEMKKQLNKIQISLDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKL5</accession>
    <name>A0A2I2GKL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_490543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708720.1">
        <property type="nucleotide sequence ID" value="XM_024853999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKL5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKL5"/>
    <dbReference type="GeneID" id="36561700"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_490543"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050285">
        <property type="entry name" value="STE20_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SULU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="258" mass="29543" checksum="EAD736450FC072F9" modified="2018-02-28" version="1">MEIVQRNEAFKKIDGKMKFSYVQMFVRQDGKLYSGKWRNRLDSPKTLDDLQAVQQIPTEDRGPEVNPTWSAVYVKTPSLLAYVDENLEKQITREVETCETLRRNPHPNIAPYYGYTETHGRVSGLCFKRYTTTLLEAVNPQRVGKVVFRSSARDLVNENMKSGLEGILAAIEHLHALGIVHNDINPANIMLDEDGTLVLIDFDSCRYIGESLRSTGTKRTHHWHDPTVDISREKNDLDAFKDLQVWLAGSVDEDFLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKX9</accession>
    <name>A0A2I2GKX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_508132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708838.1">
        <property type="nucleotide sequence ID" value="XM_024854535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKX9"/>
    <dbReference type="GeneID" id="36562241"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508132"/>
    <dbReference type="OrthoDB" id="4507588at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35815" checksum="077FE49CB3FD81F5" modified="2018-02-28" version="1">MAPRRGGGSSGGYSSGSSNQCSDYDAFATTFARIYIAFHALFFLVFVTVFFILVAKHKRTKRVAKAPLLWFCLYFSIIFSIISTALSIIFNTLSECGIFVGNDAYRASISIDWLGTTATLLVILAIMFPISQRLHHGNKGMGGLVRIAHSVTLGLFAILLIVSLSITTRVVDALYSSGYRYGLGSDIADLAIHQRRIWVACYAMGVICMLVAAATMLFALVRNPNFRRGSLRIGIPLLILSSLAMTLLDLGGYIHNTYGSFSSYRSTRYLEQSYEAQLFLRYFFYTCAFLSTLLVGSTADLHGSYAPRFDLQAPAPPMYQPRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL00</accession>
    <name>A0A2I2GL00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_435157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708858.1">
        <property type="nucleotide sequence ID" value="XM_024848874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL00"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL00"/>
    <dbReference type="GeneID" id="36556573"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435157"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="710" mass="79170" checksum="A63C37DD3C3C3A31" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLI0</accession>
    <name>A0A2I2GLI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_469217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709029.1">
        <property type="nucleotide sequence ID" value="XM_024852606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLI0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLI0"/>
    <dbReference type="GeneID" id="36560304"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469217"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="84"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="335" mass="36636" checksum="600D659C57D3E3B4" modified="2018-02-28" version="1">MDRSLDEIIAERPQQNQNRGRRPQGQGRRRDGVKKPYRDDRLDLDLDWVHDKYEDDRDARPSRAPRRPRGDRYSPSPEHASTGSKIRIENLHYDITESDLEDLFSRIGPVTNISLVYDRAGRSDGVAYVTYNRNSDARTAINEFDGANAKGQPIRLSIVHGGGGGGGGRRDRNPFDNIQRPKGSLFDRVERPRGGRDARSLSPESASDSADGGRRRRGGGRRGAGRYRRSDVSKPAPDHIDRYVPGQRSPARRSANGGGRRQGGGGGGGGENRRTANGRPRKTQEELDQEMDDYWGNATGGAAEKQAGAEEHHAPAAAAPAAPAAGGDDDVDMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLZ2</accession>
    <name>A0A2I2GLZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_431662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709197.1">
        <property type="nucleotide sequence ID" value="XM_024848090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLZ2"/>
    <dbReference type="GeneID" id="36555789"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431662"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF57">
        <property type="entry name" value="CINA C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="472" mass="51437" checksum="90144023D9BE36CE" modified="2018-02-28" version="1">MGGIFETLHRWYRGTLYQAVVLGLISFTQPGIWDALNSLGAGGLASPYFVNASNVITYVIMIVTCPLFAVAGNRFSLKWVLVAGTFYVPYFAALYCNSVFGTQWFLLFGSVICGFSAAALWVSEAAIAVGYPEIENRGTYIGIWMALNKLGSLIGNAIQLGLNIHNADKGSVSPKTYLVLIGLSCAGLPLALTVAPAHKLIRKDGSKPTFSSSEEHVSIKDGFKGLWKAMRQRYMLMLLPIFITVRWSQTYQGNYLTEYFSVRGRTLAGFIQTVVGTVATLLWGWFLDRQKIVKSRKVLAMSGWLIMLAVFIPQWVLNFIMQKQLQSQHPTPSLDIHDPGYGKAITAYCLFGVASQASVVWTYWILGTYDVHVDVLAYTTGILRSAESLGFAIAFGIGASKSASLMANLIVAFIVFWVSVPFTTYASYTVKEPGEAVGETSGPAAKDVEDGSNDDLPGNVSHAQAQEAGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GME6</accession>
    <name>A0A2I2GME6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_420837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709360.1">
        <property type="nucleotide sequence ID" value="XM_024847327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GME6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GME6"/>
    <dbReference type="GeneID" id="36555026"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420837"/>
    <dbReference type="OrthoDB" id="4497987at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="416" mass="45872" checksum="500D33ED01997AAE" modified="2018-02-28" version="1">MPLASSQRQCFVCSGAPKPSCYRNNHVKLCEKCRSMFAGNRDECPYCVLPTDRYRPTPTMRIRKSQSPRRETKRLSVTAKMVFADGPDRTMTMAEVGSQAAESSSSVEESSEESGVEEQDGHLIDEEPAQDDSNGLVDEQVVSSVEVVPVDDESADDDSADEGSVEEEPANEEPVEEESLDEEPVDDEPVEEESVEEEPINDAPIEEESVEKAPADEEPADEDPVEEEPVQEPVEEAPAEEAPAEESSIEEAPVEMVPAEVAPAQSSLRAKLAGLTLEIPDREISLQQDSNDNEVEVFPDTPEDAVPEFEKQLEELSKPREEREKAASKPVKTPTFPIKKGGAQGRIVRKGVTSRSQTPEAPSCRRCSLHGKHDKCPEQKPKVPRGPLVRGKSVREERPIKQQAQEEPNETLGECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMH0</accession>
    <name>A0A2I2GMH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_431764</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709393.1">
        <property type="nucleotide sequence ID" value="XM_024848115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMH0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMH0"/>
    <dbReference type="GeneID" id="36555814"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431764"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF92">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="239"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB54091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="671" mass="75639" checksum="8AD69BC885D00CC8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN58</accession>
    <name>A0A2I2GN58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_421044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709608.1">
        <property type="nucleotide sequence ID" value="XM_024847337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN58"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN58"/>
    <dbReference type="GeneID" id="36555036"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421044"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15048">
        <property type="entry name" value="STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15048:SF0">
        <property type="entry name" value="STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="446"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="627" mass="68718" checksum="6684BEE48BCEE5C3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNR5</accession>
    <name>A0A2I2GNR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_421210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709820.1">
        <property type="nucleotide sequence ID" value="XM_024847346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNR5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNR5"/>
    <dbReference type="GeneID" id="36555045"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421210"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="119"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="260" mass="29812" checksum="4796FBA0616287FF" modified="2018-02-28" version="1">MDLHSQLQAAWSHATTTYRPGTIEFAAIILVQIVGFLIPASFYLLIDTLFPKFSQRHKIQDARRQPTRQQILHCVKVTLFNHVWSVALAGLMLSFTGLDHAITNLDPIVPPFKTFLVDFAFGLLAREISFYYVHRALHHPSVYVYIHKMHHKYTAPVAFAAEYAHPVEHLLANVLPITLPLYLKGAHMLSLMAFVLFELWEAAADHSGYDFLKLPPAEIHDLHHEKFRVNYGTIGLMDWIHGTDVVGWDLPKKNEIKRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNR9</accession>
    <name>A0A2I2GNR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_398112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709829.1">
        <property type="nucleotide sequence ID" value="XM_024846211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNR9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNR9"/>
    <dbReference type="GeneID" id="36553910"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398112"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03021">
        <property type="entry name" value="DsbA_GSTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044088">
        <property type="entry name" value="GSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="220" mass="24501" checksum="CCA709CF4888105D" modified="2018-02-28" version="1">MATPRITLYLDVVSPFSYIAFHVLRYSPVFAQCNITYVPIFLGGLMSACGNTPPIKIKNKDLWINKERLRWARSFSVPMSEHMPEGFPVFTLATQRALCAISQRRPAQLVPAIEALYRAFWVDGVTNIGQPEGFGPVLEKVLGQADAQEILQTMSQAEIKSLLTSKTDEAFKSGAFGLPWFECTNAKGQTEGFWGIDHLGQVAEFLGLNRKADRGFRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP65</accession>
    <name>A0A2I2GP65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_344463</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709973.1">
        <property type="nucleotide sequence ID" value="XM_024843464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP65"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP65"/>
    <dbReference type="GeneID" id="36551164"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344463"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="28"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="249"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="540"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB54671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="879" mass="97911" checksum="614C6BB2F0248400" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPJ7</accession>
    <name>A0A2I2GPJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_442796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710085.1">
        <property type="nucleotide sequence ID" value="XM_024850486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPJ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPJ7"/>
    <dbReference type="GeneID" id="36558185"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442796"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001166">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_4G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="475" mass="51409" checksum="1A0771F61FCC3058" modified="2018-02-28" version="1">MNSYLLNRALGSITPSDFHVALTTRLVHHLEPAPGVRFSSYTGPAAGDAQIGCEDEIYAHKAGVNVLASDQNEGRFLVSGGADPSIHLWDLESRGSQLSHTHRSIASVNKSSHEDAHTRSLTSLSIYPFDPTPSTILSTSHDGTLKLSALEPTGITPVHTFKLDCTPYAHSMSSHSGSPLLIAVGTSEKPVRLLDLRSGLSTHGLPGHSSSVLSVSWAPHRPHILASASADHRVILFDIRRGGHNSAIATLDMDDAVGLVPPQTAPPGHDSRPAFSPYVRAHGGAVTGVRWTTNGTHLVTAGQDARIRVWDATTGANTMVHFGPRVRNSVSSHLAERAPLVLPRGVMKAGHETLLWPNFNERDDRGEIFMFELREGTFIKRLRVPGLAINAHSMRGRSSALSAARINALAWRGNGAAGEGMEMFSAHGDGTIRTWVSREPEGEPDEEEEAEQADRKRKRDVLEEIYQGFMPDSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ47</accession>
    <name>A0A2I2GQ47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_432517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710296.1">
        <property type="nucleotide sequence ID" value="XM_024848280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ47"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ47"/>
    <dbReference type="GeneID" id="36555979"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432517"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="215"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="526" mass="59371" checksum="80B533D4DC589DA4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ68</accession>
    <name>A0A2I2GQ68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GET complex, subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_432556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710327.1">
        <property type="nucleotide sequence ID" value="XM_024848288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ68"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ68"/>
    <dbReference type="GeneID" id="36555987"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432556"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB55025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="32675" checksum="AD43B8E2FFBDB6DF" modified="2018-02-28" version="1">MSSVEESPAQRAARLRRERREAKIKEGGAARLDKITSMSGRTPAAERQEQDAAPSPSPSPQPPASISPGPETQSSSPADTTNQPEPSIAPTHPFPDTQAQSPESLQAQQEAFRALLRQTGPPPGSQGGGGFNQFNQGSLEEDPTVKLLNSLMGGMAAGEGAGAPGGGNGNGNGPPISQADIATALGLPPFVASMLPGGSQPQTESEKTAIWTWKILHVVFAIAVGVYFLVLMGSSVSLYGEAPPPPATARSPFLYFTTGEMVMTGARVFLKRGSGQAGLGLYFNLFRDIVRDGSLVVFLMGMGAWWNAEWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQC9</accession>
    <name>A0A2I2GQC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_505708</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710388.1">
        <property type="nucleotide sequence ID" value="XM_024854317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQC9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQC9"/>
    <dbReference type="GeneID" id="36562023"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505708"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB55086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="526" mass="59097" checksum="F050411CBB88C443" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQQ0</accession>
    <name>A0A2I2GQQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_452664</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710501.1">
        <property type="nucleotide sequence ID" value="XM_024851290.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GQQ0"/>
    <dbReference type="GeneID" id="36558989"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452664"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1093"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1164"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1282"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="76"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="716"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB55199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1311" mass="146623" checksum="057133FB3A201FB8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR59</accession>
    <name>A0A2I2GR59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_432908</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710669.1">
        <property type="nucleotide sequence ID" value="XM_024848366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR59"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR59"/>
    <dbReference type="GeneID" id="36556065"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432908"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000029">
        <property type="entry name" value="Mitochondrial intermediate peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="17">
        <location>
            <begin position="296"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB55367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="798" mass="88860" checksum="52D6600FEC14EB73" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRB0</accession>
    <name>A0A2I2GRB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_39425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710686.1">
        <property type="nucleotide sequence ID" value="XM_024846052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRB0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRB0"/>
    <dbReference type="GeneID" id="36553751"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_39425"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="597" mass="66068" checksum="34AD5E2AE73789D6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRS6</accession>
    <name>A0A2I2GRS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_461412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710878.1">
        <property type="nucleotide sequence ID" value="XM_024852035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRS6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRS6"/>
    <dbReference type="GeneID" id="36559733"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461412"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="269" mass="31318" checksum="7CA458DE78AD64C0" modified="2018-02-28" version="1">MESLPSAKPVARKPERKDRRQKLKLIRKRIDKLGNGYLEDSDLIAAGVDRQPMSLEDNDILLPQFFAPYNAKVDPPDVKVDPDDDDWITENFPSFDELDFDEFAHNSEFFLHMYIQHGGLPQEDEFPPAPSYRDWGDFGFPDLVEIFGNPRWQLQTAWDLPLRPHIKCMIITEAVPDDRLLYGEIVTIDEIIQQRLRTKITRKHVDAPVLMFSFIGSQVRVLEANFNGKELVVRATKLYDLKDDDKKGWELSIFLKKWWLGDATKKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSE7</accession>
    <name>A0A2I2GSE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_433281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711099.1">
        <property type="nucleotide sequence ID" value="XM_024848448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSE7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSE7"/>
    <dbReference type="GeneID" id="36556147"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433281"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="252" mass="29046" checksum="AEC18C8CD6668352" modified="2018-02-28" version="1">MPDRVAPYIRKTMSTATPSTESDNRPVFFFDIDNCLYSRECNIFGHMQELINKFFTTHLSLSTEDAHVLHMKYYKEYGLAIEGLTRHHKIDPLEFNREVDDALPLDDVLKPDLKLRQLLEDIDKDKVRLWLLTNAYVTHAKRVVKLLQVDDMFEGVTYCDYSQTPLVCKPSQEMYEKAEREAKVPSGAKSYFVDDSHLNCKHAAERGWETAHLVELGVTPPSAPASQYMVRSLEDLRICFPHLFKTGSSLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQ88</accession>
    <name>A0A2I2FQ88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_491262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000028">
        <property type="protein sequence ID" value="PLB42781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQ88"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_491262"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="113" mass="12878" checksum="E6171BA9C41F55B7" modified="2018-02-28" version="1">MRFPRRKGPAGPVLAVRRTGQPDPRFNYELFNCNNFNIRYWSWNYAAAGTRLALQLFLVKGFRLYSFQLRDPKEPRISIYCHYLPVSGLGNLRACCLLGCGSRFSGSLSGIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQT7</accession>
    <name>A0A2I2FQT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_370630</name>
        <name evidence="14" type="ORF">P170DRAFT_370815</name>
        <name evidence="13" type="ORF">P170DRAFT_370867</name>
        <name evidence="12" type="ORF">P170DRAFT_370881</name>
        <name evidence="11" type="ORF">P170DRAFT_370930</name>
        <name evidence="6" type="ORF">P170DRAFT_371279</name>
        <name evidence="2" type="ORF">P170DRAFT_371452</name>
        <name evidence="10" type="ORF">P170DRAFT_395444</name>
        <name evidence="9" type="ORF">P170DRAFT_395521</name>
        <name evidence="1" type="ORF">P170DRAFT_396016</name>
        <name evidence="15" type="ORF">P170DRAFT_419555</name>
        <name evidence="8" type="ORF">P170DRAFT_419924</name>
        <name evidence="5" type="ORF">P170DRAFT_420063</name>
        <name evidence="4" type="ORF">P170DRAFT_420149</name>
        <name evidence="7" type="ORF">P170DRAFT_451521</name>
        <name evidence="3" type="ORF">P170DRAFT_459932</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000033">
        <property type="protein sequence ID" value="PLB42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000025">
        <property type="protein sequence ID" value="PLB42818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000024">
        <property type="protein sequence ID" value="PLB42821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000023">
        <property type="protein sequence ID" value="PLB42844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000022">
        <property type="protein sequence ID" value="PLB42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000022">
        <property type="protein sequence ID" value="PLB42863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000019">
        <property type="protein sequence ID" value="PLB42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000019">
        <property type="protein sequence ID" value="PLB42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000018">
        <property type="protein sequence ID" value="PLB42932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB42996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370630"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370815"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370867"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370881"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370930"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371279"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371452"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395444"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395521"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396016"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419555"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419924"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420063"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420149"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451521"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459932"/>
    <dbReference type="OrthoDB" id="2387577at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB42844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB42852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB42863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB42932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB42952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB42976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB42996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="81" mass="9165" checksum="E436A13504D6C5C1" modified="2018-02-28" version="1">MSTTWRENYSFPRIFKGRRGRTGPCKGCQEEKITLPRTPADVSAFSYVAVENPHPGAGMLTGFPFGTRRTRAPFKRNFPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRK4</accession>
    <name>A0A2I2FRK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_451315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698543.1">
        <property type="nucleotide sequence ID" value="XM_024851176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRK4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRK4"/>
    <dbReference type="GeneID" id="36558875"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451315"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="30950" checksum="940AF9032487C64C" modified="2018-02-28" version="1">MAQDQPSHPRPGESREDNREIKLLHFIYEQPNRDEIQGNPQKVLELIDEFATQYHFVNVGATKGNVVTDLIAERKPQVMIELGGYVGYSAILFGDAVRRAGGKRYYSLEVNPEYAAVANMLIELAGLRDFVRILVGRSDLNLHKLYATGEVKQVELLFLDHYKPAYTTDLKLCEQLGLIVPGVSVLAADNVIYPGNPPYLEYVRGSVEQKREAAKSGPARSFNTEGMSQRTVQSYIGEDATPLFEITGNPNLVYTSSLEQPEGSRDGVEVTRCVGIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRU0</accession>
    <name>A0A2I2FRU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_419222</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698629.1">
        <property type="nucleotide sequence ID" value="XM_024847271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRU0"/>
    <dbReference type="GeneID" id="36554970"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419222"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF9">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="507" mass="56165" checksum="7D6EA1343C40A01A" modified="2018-02-28" version="1">MNSVRIAHAARSSSITMDPKDDLKSPPPVLSEEAGVIVAESIAVDVAIERSVVRKLDFLLLPVLSLMYFFNSLDRSNLGNAKTDGLEQDLNLVGNQYSIILAVFNVTFCLFDLPSNLLLKKYSGKVMLPLMMVGWGSITLLQCAVYNFAGLLVCRLFMGVFEAGFFAGVIFYLTQFYKRNEMAFRLSIFYGMVTIAGAFSGLISFGVFQIKHQLPGWKYLFLIEGAATLIIALFSFYWLPADSAHWHLFTEDEARTAQARLLQDGSVRTGTNEQLSIRAALAALIDWRVLTWAVSCFCYGIAQSSVSNFMPQMVALLGYSTIKTNLYTVAPYCAGTVFLWTICKSSDHFRERSTHLAASLMLTFTGYIILIAVDAPTHKPLAYFACFLLASGAFVPSSVFHSWHTNNVTDESQRAATVGFLVGAANCAGIPSSLAFKADTAPRYKPALIVNCAFLLFGVLVILAMGAWFRWDNRRRDREQGVRLTAKDVATKSLIGGWKDPNWRWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRV2</accession>
    <name>A0A2I2FRV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_431285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698638.1">
        <property type="nucleotide sequence ID" value="XM_024848018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRV2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRV2"/>
    <dbReference type="GeneID" id="36555717"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431285"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="6">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="5">
        <location>
            <begin position="251"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="766" mass="83160" checksum="DB883EED56832A8C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS10</accession>
    <name>A0A2I2FS10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_481367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698722.1">
        <property type="nucleotide sequence ID" value="XM_024853863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS10"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS10"/>
    <dbReference type="GeneID" id="36561561"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_481367"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="160" mass="17668" checksum="B4ED03005C02379E" modified="2018-02-28" version="1">MTRYLFQALNGSPLEFSFPVLISQIGSIPQQSLRESEVKDLSRAQEKHFLVLLWQSSTCIHPVISEADFRAYYESLWASSTPSDQDGRIPSVLVNTTLFVNTFGHSGTDGVGADRGRLAGLGGQCPSRLPSVNWSGLRTTRPGYHHAAYRCDLPYCISFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSQ7</accession>
    <name>A0A2I2FSQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698980.1">
        <property type="nucleotide sequence ID" value="XM_024850244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSQ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSQ7"/>
    <dbReference type="GeneID" id="36557943"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441136"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="47442" checksum="77F9A6C069276C1C" modified="2018-02-28" version="1">MRKTLLIVYIHGFKGDDDTFGDFPEHFRAQVSRSLPSVKVATAVYPKYETRGDLKECVSVFREWLQNQVIDLEVENRTASPTVDPSVHVFLVGHSMGGIVAAETLLLVASEQPIPPKHADPLVDSGTAENAPAIEPGSFMFPHIQGVLAFDTPFLGIAPGVVSYGAEGHYRNAASAYNTISEVAGIFGLGGANTSSKGAGASQAKRGREALPSQSGSNAPSADAAATPSWQRWGRYAMFAGAAGAVAAGGAAAMYSQRDRLTDGFGWVSSHLAFVGCLARPAELRQRLVLLSQVHEERGIGCTNFFTCLGQGAGSLVEKGDQAKTSFSQKIIRSKHRTFCTLPTELEGQDMRFLPAPGLGWARATNDKAGDEVKAHVTMFLPTDNPAFYDLVNDACRVLVKSVDKGWYAGATTIPVEEIPQTENGKAQASTDSGFMDGDDVVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FST3</accession>
    <name>A0A2I2FST3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_393601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698995.1">
        <property type="nucleotide sequence ID" value="XM_024846027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FST3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FST3"/>
    <dbReference type="GeneID" id="36553726"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393601"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="334" mass="38148" checksum="6F27171C644A9A30" modified="2018-02-28" version="1">MRRAHAADDLPSQTRRACSQCRRLKSRCEGGPPCRECVHRKVFCSLDASDRTNRRDSVRHLLDRVPELSDTESPRPERRDQHFIDLYFERFHPHWSFVHRGSFNLSRETPLLAQSMMVIGLWASGERKAQRAALDLHRTLDSAIHQQREVWDALHASNSDASSSACSWPIPTYQAILLHIIFSIMQKGGSSVGFDLKLSLPPADEQLLHSLVASCKRLGMFYYPNMLARVDPETIATLAWVSIEEVKRFDLALYRVHKLLSRTDDDHNVAETSRGGLTASDLQFPMPSNNRLWNAKGREEWIPAIMEDASLDTLDGTKREEWICNSAELIDLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT22</accession>
    <name>A0A2I2FT22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_480723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699066.1">
        <property type="nucleotide sequence ID" value="XM_024853807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT22"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT22"/>
    <dbReference type="GeneID" id="36561505"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480723"/>
    <dbReference type="OrthoDB" id="5427091at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15828" checksum="5C4A516CCCDEEAE2" modified="2018-02-28" version="1">MSFDSFDLGQDLSTVSQMDQSNSPNASFGIDASDPLFYVCWRRQSCRWCLEGDAACSWCAVTSTCVPNSAHLPILAPLGSSQICPLGSKERWELRALPFGCNVSTITFLTAVGSVLSTLAAIALGMLVGEVEGEGLGIGYGKGKGERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT68</accession>
    <name>A0A2I2FT68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_485619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699137.1">
        <property type="nucleotide sequence ID" value="XM_024853925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT68"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT68"/>
    <dbReference type="GeneID" id="36561623"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_485619"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="31329" checksum="97336F9F1038E37A" modified="2018-02-28" version="1">MTEPRALPPGSKLWLLDLGTLDIDASYVLSGANVPLHGARPEPHETRPCVMIAGLLYHPDVGLLLFDTGSREDVIKSWDKEFLECAPRTWDKSIHSLPAAIKATGAGEIGDVKAVIMSHLHLDHAGGLEHFFGTDVEIWCHEKELKNAFWASATGADAGLFLPDYLRADLLNWKTVSEERAVLWDGVTLHRCPGHTEGSLVLELTLMSGTVVLMGDLFHVKENYEDGRPQGFLMRNYNQWFRSREYVRRLVKQTNAKVCLGHERMYFDMFEKSPRFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT75</accession>
    <name>A0A2I2FT75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCAAT-box-binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_393841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699142.1">
        <property type="nucleotide sequence ID" value="XM_024846035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT75"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT75"/>
    <dbReference type="GeneID" id="36553734"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393841"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="669"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="943"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="979"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125448" checksum="B1A5C68F1F3140AB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTC4</accession>
    <name>A0A2I2FTC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_468634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699195.1">
        <property type="nucleotide sequence ID" value="XM_024852566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTC4"/>
    <dbReference type="GeneID" id="36560264"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468634"/>
    <dbReference type="OrthoDB" id="4427207at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="284" mass="31487" checksum="17DE8F44D362BEAD" modified="2018-02-28" version="1">MSSDDDDFLTPRGLLVEGSFVCDGPSFQDLQTAVNASLELPYTQDRFQYWSGISPMGWNILNTYFIPLVDTCYSAVQSIQGLGHGYREVGTVCDLILSTASTAQSDYDALFQGLNDLTNDPDNEALREQVRKLTADRLDGVTTLETKTDTTFGEMKDGTDGVKTCEDQLKTILRNLDDSELEDLLRKNDPEDDLEDDLAALKYIRDKVAAMDMEAQSGGALQNLQLALGSVRVVITDLTAIQNAIENTSEPANEIILGHEKAKIIRKWSDLATEVQKFKDHYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTZ5</accession>
    <name>A0A2I2FTZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_416521</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699420.1">
        <property type="nucleotide sequence ID" value="XM_024847124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTZ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTZ5"/>
    <dbReference type="GeneID" id="36554823"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416521"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="417"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB44118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="856" mass="93549" checksum="7A7685CE1A81F994" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUE5</accession>
    <name>A0A2I2FUE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_430122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699519.1">
        <property type="nucleotide sequence ID" value="XM_024847932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUE5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUE5"/>
    <dbReference type="GeneID" id="36555631"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430122"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF116">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014182542" evidence="1">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="55"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="385" mass="43198" checksum="B902B1FA7EA3517C" modified="2018-02-28" version="1">MRSIVLISLSVLFSRASTAQTFSDLAIQKVLRDAAPIFGEYHNSNSLKATWMKDYDDDTPITAMNLPGTHDTSTWNYTRETKHALEGLNRINDAGIMAPYLFYRCQSSPLIDMLNGGIRVFDLRFAFDVTNLTLVFYHGNALQSETATVEDVLFGFYQWLDDHPTEALFLSFKDEGGTAKYVPDSAATQQAIHNVLTSNHARRYFVQAKNELGTLGDTRGKITLFRRFSLDKIKGADLPGIYFPGSQWKDNSNNITLVYNSDKNLKAYIEDHYNVGGFDWPKIIQRKYNATTVHLLEALKNEHSDDLFWTFASGGADIVGLYPEAMGLGSIVAETGVNKQLLSFLKQHKGKHLGIVMYDFFKEDDGIVDALLNLGSTSGIHYDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUQ2</accession>
    <name>A0A2I2FUQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_503002</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699629.1">
        <property type="nucleotide sequence ID" value="XM_024854190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUQ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUQ2"/>
    <dbReference type="GeneID" id="36561896"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_503002"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF402">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="60"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB44327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1050" mass="111030" checksum="3BB7B7E04EA81516" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV08</accession>
    <name>A0A2I2FV08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_287233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699781.1">
        <property type="nucleotide sequence ID" value="XM_024843215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV08"/>
    <dbReference type="GeneID" id="36550914"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_287233"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="12708" checksum="9CECE2B671259FC4" modified="2018-02-28" version="1">MHRLFRSTDVFPSHPPSLDGMRCRRDIIGHANEWIGRRQQSTFLHCPAGWVRPSTPEPLRRIVVSHSNARGYWGWRHLSSTVSRNPPSSHDDTVRLVQLTNNVCDGQIITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV36</accession>
    <name>A0A2I2FV36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-ascorbate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_450586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699805.1">
        <property type="nucleotide sequence ID" value="XM_024851134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV36"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV36"/>
    <dbReference type="GeneID" id="36558833"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450586"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13873">
        <property type="entry name" value="CuRO_2_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017762">
        <property type="entry name" value="Multicopper_oxidase_fun"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03390">
        <property type="entry name" value="ascorbOXfungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014199112" evidence="5">
        <location>
            <begin position="24"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="38"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="163"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="448"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="625" mass="70521" checksum="2F414DCF2BFB5E01" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV44</accession>
    <name>A0A2I2FV44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_367630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699796.1">
        <property type="nucleotide sequence ID" value="XM_024844816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV44"/>
    <dbReference type="GeneID" id="36552516"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367630"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27238" checksum="E37144C56CFF02B0" modified="2018-02-28" version="1">MGFGGVVLRFFNLAIRVLQFLDAAVILGIFSYFLAVQTRHDQTIPQWMKATEGLSGAATLYGLLGILFTCCLGGIAFFAALAVILDVCFVGAMVAIAVMTRDGTQKCTGNVKTPLGNGNSDDESASNVTYGFVCELQKVAFAVSIIGIFFFLVSILFQVLYARHHKREKRFGPSPANGYTYGTQGKSLFRRNKKNNPETASGDDILPGHPTPHDVELGTPEEKPGLLGRMFSRKKSNANAPGYGNSAYTGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVB0</accession>
    <name>A0A2I2FVB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699882.1">
        <property type="nucleotide sequence ID" value="XM_024850173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVB0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVB0"/>
    <dbReference type="GeneID" id="36557872"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440828"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="345" mass="36790" checksum="FCA3A666A026D942" modified="2018-02-28" version="1">MAQTQPQQFSQSFSPPGSSPSPGAPSPVNGGGVPPPPKRQRLSPLPQSPYASPSFGTLQLPQNIPQNLPQNQIAASANAINVNGLPQTPVQAPAPAPPGAMGPPSRPADKATDAAELTDVLASSGIDVREEEAFLTSSYSGPGVQVQQPPRPQPQQHHHQPPLPQQQPQPPINTSFTSQTSTGTVSSQPSFSEPSQLKPPTAQGSPLTESSTQPPAPFKDPNEPTREDSEAARRAQYHLQEPFLLTKVLEQKLQRRGFELGVRIPAEGLFHPVPGRQAPIEVTGPDGSSIVRTGQTILNQEGAPLVDILNLMSLSCEERLRTVVDYSSTLARSRREHSHGDVPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVD3</accession>
    <name>A0A2I2FVD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 22-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_392975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699905.1">
        <property type="nucleotide sequence ID" value="XM_024846002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVD3"/>
    <dbReference type="GeneID" id="36553701"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392975"/>
    <dbReference type="OrthoDB" id="5327700at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="48087" checksum="208F6705BDC0FDC4" modified="2018-02-28" version="1">MSFPYSQDARRRGAGTGFSATGRRTFMGYWVPLALTVGVATIGVAAWIWSERSEDDDDDDNHHHHQHNRDYPHEDDRFPAPGPAAGGPGLPRDAYEEGDYARATGTDIHGEHPDDAGVMARMQGALRRTPSPQQLFDGASKRVAAGVAAAGAFVGGALTSIREEDRRDFEDHSRWSEEVENRASRGRGQQQPDVTAPSMSGALPGQVGVGGPAAGADKRKRTVAIVVSSDASHLDPEEFSSEHVSILSHLPEHVNPDTTRIFVMIYAPGLKHAPSQGNGSHPTLSVTSSYSNIAPEEAQSLGELPSPGTVPAADEPEGSTPLFKTMYTQAQAIVEKSNAIMPFNTRTGYVHLVRHLSPDIVYVQESLAGKEGEAVHHISGWVRQVVVVVGDEGGRGGLVDSEDESALGDKGEPWWQKEGTTGIGKRIDVVDALRTGDDWRRRVSGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW69</accession>
    <name>A0A2I2FW69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="1">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_415685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700183.1">
        <property type="nucleotide sequence ID" value="XM_024847075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW69"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW69"/>
    <dbReference type="GeneID" id="36554774"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415685"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000208">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF75">
        <property type="entry name" value="SYNTHASE SUBUNIT OF TREHALOSE-6-PHOSPHATE SYNTHASE_PHOSPHATASE COMPLEX (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB44881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="478" mass="53873" checksum="2F8C2E0FD4EEC2D1" modified="2018-02-28" version="1">MPPSVSVTKKNMIVVSNRLPLSIKRVDDGFESNLSGGGLVTSLSGLTKSTSFRWFGWPGIEVKDENEQEKVLKSLSEHNAVPIFIDEQLAHDHYNGFSNSSLWPILHYQSGVDFDDGTWQAYKRVNEIFADIIAEEATEDNMIWVHDYHLMLLPSLLRERLEKKGKTFAIGYSLHTPFPAEDVWKTLPVRNELVEGVLASDLIGFHTDEYKRNFVACAQTVGASTETEGEIQYKDRTIMADKFIVGIDPQKFSDALQDSDVRNRIQELQERYKGVKVILGVDRLDYIKGLTPKLKGYDYFLDNHPELSNKVVLIQVAVPSREDVKEYQELETEISTIVGKITGKHATADGTPLIYIHRSVSFTELTALYSLADACLLTSTRDGMNLVSFEYIACQAQRHGVLVLSEFAGAASFLKEGSITFHPANIPEMSDSIEEAVTMSAEDRKRRYEGLREFIETNTSAKWGEAFIERLSERLQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWD3</accession>
    <name>A0A2I2FWD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700227.1">
        <property type="nucleotide sequence ID" value="XM_024850000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWD3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWD3"/>
    <dbReference type="GeneID" id="36557699"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440127"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05269">
        <property type="entry name" value="TMR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="305" mass="33893" checksum="6195A0342A32E59F" modified="2018-02-28" version="1">MTLKYLITGATGGLGEQVLAYFAANRPASEFAAASSRESNRKQFEDRGIAFRHANYDDPASLEAAFHGVENLLFVSTNVFDNEKRQKQHENFINAAKKVGVKHVWYTSLAFGGYESTSKAAVQQVHLITENLLKKSGITYTSIREGVYTDAFPVFINWFPTTSTISLPSDGPMALTLRHELGEATARLMIAGGHENEIVLLTAQEAIRPSEIVDVINKTTGRQVKFEIVSGDEYVRRNGANDLGGKPAAFFEMVRSWWDAIEKGELETTSPLMSEVLGREPVKASEAIRDLLTQNPDFTWHQNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWF3</accession>
    <name>A0A2I2FWF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 15">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="6 14 15">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_366483</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 14 15">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14 15">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6 14 15"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700239.1">
        <property type="nucleotide sequence ID" value="XM_024844760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWF3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWF3"/>
    <dbReference type="GeneID" id="36552460"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366483"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14 15" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014115564" description="Endo-1,4-beta-xylanase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="17">
        <location>
            <begin position="43"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB44937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="231" mass="24684" checksum="2BBA0D26B4B157C6" modified="2018-02-28" version="1">MVSFSSLLVALSAAVGVLSAPVEQAPEFPDLSFNGTLHELAERSTPSSTGWSNGYYYSFWTDGGGDVTYTNGAGGSYTVQWSNVGNFVGGKGWNPGSTRTINYGGSFNPSGNGYLAIYGWTQNPLIEYYIVESYGTYNPGSGGTYKGTVTSDGGTYDIYTSVRYNAPSIEGTKTFTQFWSVRQSKRTGGSVTTANHFNAWGRLGMSLGNHNYQIVATEGYQSSGSASITVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWU3</accession>
    <name>A0A2I2FWU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700414.1">
        <property type="nucleotide sequence ID" value="XM_024850035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWU3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWU3"/>
    <dbReference type="GeneID" id="36557734"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440246"/>
    <dbReference type="OrthoDB" id="5334391at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="509" mass="58630" checksum="0BEC2999D4C4DB4F" modified="2018-02-28" version="1">MPGIQDPGRLGMAQLPREIFWMVLHLLRPRDIVRCRLVSQSWNVAFGDPANLIPLLKEYFPLAKEVRALHEKGRSSPTLKTAEDNNYWRSLFDRIAARYDHLRRGKARSVQKYGLCGDFGSSGEREWFPVQPWDIHASHLMQRVDCPFSESFWTYEDGLVVYPSAHHSALVLLDLESDRKFMVPFMITGKVMRRIRLQKRLLVVEWAEPKAFHWLNDSDGVHRHFASSFDVNKTSSGWSVTFRNEWKIMFLGHPLSERDRFYSSHSQTHYAIYIWQPNRSLYTADEDAPIESLSVWDISKPSSYRPSLDPFGRLRQDGEDESPSIISRFGFRELGFHSVRQRGLPGMQSLNISDDDQSIEIVENICTGPMDRLVGPAEWTSQVQVTSLPIIGNGPCWRRCGDPALPPYRGNSSLQTKPLTFAVCDEPWYAIVSEVLDEEAQVGFCLHLSPITWPFNLKMFLTIRTPTSTLTLKQDQVFELVGRGKIHGNEHYLVGENGNRELVIYRFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX57</accession>
    <name>A0A2I2FX57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_479679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700458.1">
        <property type="nucleotide sequence ID" value="XM_024853703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX57"/>
    <dbReference type="GeneID" id="36561401"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479679"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014189394" description="DUF7729 domain-containing protein" evidence="2">
        <location>
            <begin position="45"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="141"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="386" mass="41792" checksum="02F5334D11FEDA62" modified="2018-02-28" version="1">MITCVRASASRPSSSLHASHQRPVIPRLLLCVWILLAIPSVVAASVLPADARSELNALRSLPSVSPSDKELVHDDLEDVSHSPQERAQWNHVLRRDVTLELDPSLSDMAASLPILVASDDHDRTGGGELSSLVGRANSKDMPEPFDTSTRTNFTSSTCETFVNDFLSNSTFTNCHAMSMLLRNSHSFFQTVRSATALSHVLDISCSADADQCSAYMTDLAGRLLKKDACGEDYEEGNTIVTDAYTNMVAYEPIYRATCLKNPKTSDYCFVDAATSSDNSADYGVYFIPFDDAITSAPYPTCNKCLQASMDLFAKFAEKDGQFLVRSYLPSAQGVNSKCGSDFANVNITVGEDKLLSSAASWTAGRPGLSLQYIVALCLAVIFLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX90</accession>
    <name>A0A2I2FX90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_513285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700560.1">
        <property type="nucleotide sequence ID" value="XM_024855091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX90"/>
    <dbReference type="GeneID" id="36562797"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513285"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="276" mass="31360" checksum="B70FEAC7F5C6981E" modified="2018-02-28" version="1">MPRAPKTPRNQRDAGSSSTRTRRRPHFEFGYSEDRQILLAYLSLVSERPDMREVYRILANEAYSLGQLKYTTPPSLQLPPFCASKSIANAFQLPANRKQVSFLHEMSRELRNDRMQRKEHSRLAAEAGDESDSDSGTVIEAPTPSQSSETSVSMTPETPAYSRHHQVRDATPVGQRHEARSTGRRGRARDSGPEPRRGVSTHNLRRQTVRDNYRSARDVDDRPRGNREDALPPRQPLRGRRESARSSRDQGRNRSSPTPGPAFHIPVMQLRPMSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX91</accession>
    <name>A0A2I2FX91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein BRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_467806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700562.1">
        <property type="nucleotide sequence ID" value="XM_024852492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX91"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX91"/>
    <dbReference type="GeneID" id="36560190"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467806"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="69"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="40794" checksum="7C01DF434C3FF866" modified="2018-02-28" version="1">MAAVYNSVSKKQARQLAKEQDSAEEDMEMEDFLGPDDSSDSDEDEDEEEDEDALSSAKKQLAAGFMPKTRVLMLTSRGVTHRHRHLLADLASLLPHTHKETKLDTKKKTAGYNLLLNDLADLHSCNVIFFLEARKRGQDLYLWLSRPPNGPTLKFHVNNLHTMGELNAGFSGNCLKGGRGLVVFDRSFDEQGPDMSKPGNEYRGLVREMLRGVFCVPKRGVKGMKPFVDRIIGIFGVDGKIWIRVYEIRESETGGKKTLEEGEEAKLAPKSKDGLPEVSLVEIGPRFVLTPIVILEGSFGGPVIYENKEYVSPNQVRSEIRMSKAARYSKRRDVQTDRLSKRSDLGLNEGQRKPGALDNRKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX93</accession>
    <name>A0A2I2FX93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB family kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_458753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700561.1">
        <property type="nucleotide sequence ID" value="XM_024851818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX93"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX93"/>
    <dbReference type="GeneID" id="36559516"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458753"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004454">
        <property type="term" value="F:ketohexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01939">
        <property type="entry name" value="Ketohexokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000072">
        <property type="entry name" value="AT09463p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034093">
        <property type="entry name" value="KHK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="314" mass="34196" checksum="3567F215B2321BE0" modified="2018-02-28" version="1">MSLVAVGACYVDTILTTPHYPGEDDKLRASSISRRRGGNCPNSLEVLKQLTGQGASAAGVSLDLVAVLPAKSSIASQQIRSALEPRVRLDHCIYREEFNEPASSYIIKSQSSGSRTIVNYNELPEMTVNEFTQVADDRGSKAGWYHFEGRIPDVILACIRYLRERHPSVRVSVEVEKPGRPGLQELAAEADVVFYSKSWAQGNGYGSAEECLRKQSLLTRNASLLFCTWGQDGAMALETSTNNVIHSPAYAAEGFQVVDPVGAGDTFIAGMLYALIWQGDNWDVSRKLEFSNRVAGMKVAQEGFSGLARALPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXK1</accession>
    <name>A0A2I2FXK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_413456</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700662.1">
        <property type="nucleotide sequence ID" value="XM_024846980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXK1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXK1"/>
    <dbReference type="GeneID" id="36554679"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413456"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="495"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="632" mass="69419" checksum="7EBFC8FAFEF6E913" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYI1</accession>
    <name>A0A2I2FYI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PolyC-binding proteins alphaCP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_449331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700989.1">
        <property type="nucleotide sequence ID" value="XM_024851039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYI1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYI1"/>
    <dbReference type="GeneID" id="36558738"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449331"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="279"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="362" mass="38601" checksum="F3552422674A7AFB" modified="2018-02-28" version="1">MDSSDLHATTIVDETLTDAMIDDGDIEITPKTEEEYAQSTLTLRAIVSSKEAGIIIGKAGKNVADLRDETGVKAGVSKVVPGVHDRVLTVTGPLHGTARAYALVAKGLLEGAPQMGMGGIVSNNGTHPVRLLISHNQMGTIIGRQGLKIKHIQDASGVRMVAQKEMLPQSTERIVEVQGTPEGIEKAVWEIGKCLIDDWQRGTGTILYNPAVRASVGSGPVNNSGASSTSSTGNGYSSRPYNRTGNGADFSDQSGGYSRRSNPDISNRGFPLVTEDGEEIQTQNISIPADMVGCIIGRGGTKITEIRRSSGARISIAKAPHDETGERMFTIMGSAQANEKALYLLYENLEAEKTRRSQLPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ33</accession>
    <name>A0A2I2FZ33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_512428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701108.1">
        <property type="nucleotide sequence ID" value="XM_024854989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ33"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ33"/>
    <dbReference type="GeneID" id="36562695"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512428"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="193"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="330" mass="35785" checksum="C3E5F0227497DC3C" modified="2018-02-28" version="1">MPLNILLYGVGSVGAIYLHQLQRAGCTVTAICRSNHDVVATSGFTMTSALFGTVTYRPDHIYRSVSDIPSDQVFDYIVVTAKCFPDSNPSLAEQLRPALTNPPRRTTAIVLAQNGIDIEAPIAAAYPDNPLISAVIYLPATQTAPGIITHPEPLNHIELGTYPSSAPQEHVDSATRFAETMRWGGGEATVFEDIQGARWRKLMVNAAWNPIGALSLCTDGGFLVTSPFARDVVWGVMMEVVALARRAGVEGVDEEAAEKLFQISKRRAELGTGRALSMLQDVRMGRPFEVEAIVGNAVRLGRKLGVEMPRLETVYALAKGRYDVMVESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ72</accession>
    <name>A0A2I2FZ72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_467112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701230.1">
        <property type="nucleotide sequence ID" value="XM_024852455.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FZ72"/>
    <dbReference type="GeneID" id="36560153"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467112"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1011"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1096"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1198"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1283"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1312"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="319"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="682"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1099"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1377"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="927"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="937"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB45928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1666" mass="184048" checksum="8D970ACFA0F1093C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZJ6</accession>
    <name>A0A2I2FZJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701353.1">
        <property type="nucleotide sequence ID" value="XM_024849909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZJ6"/>
    <dbReference type="GeneID" id="36557608"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439741"/>
    <dbReference type="OrthoDB" id="5425892at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="12413" checksum="4CD35CDDBDF5F7BA" modified="2018-02-28" version="1" fragment="single">MDQTSNRTIESLSYFRSGEESSHDHPRAYLTTELEFQTILLPGNPNKFGTNHPPLQTLDDDLEPRVLEKPWKPSDGRSHSWSEADRKHELQARLLNVEEGVNHGFTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G032</accession>
    <name>A0A2I2G032_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase/xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_458326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701531.1">
        <property type="nucleotide sequence ID" value="XM_024851785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G032"/>
    <dbReference type="STRING" id="1392250.A0A2I2G032"/>
    <dbReference type="GeneID" id="36559484"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458326"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09001">
        <property type="entry name" value="GH43_FsAxh1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014165640" evidence="6">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="320"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="518" mass="56869" checksum="5862E53DF150862F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G091</accession>
    <name>A0A2I2G091_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_263157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701548.1">
        <property type="nucleotide sequence ID" value="XM_024843097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G091"/>
    <dbReference type="STRING" id="1392250.A0A2I2G091"/>
    <dbReference type="GeneID" id="36550796"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_263157"/>
    <dbReference type="OrthoDB" id="3436860at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17370" checksum="00B0511827406642" modified="2018-02-28" version="1">MIDLSIHNNPTLKFRLHIVIGALLFLNFILIIARLANPGTPASRANTWGIAVCVKSAVFMAYQIVSTHVNRFKRWASPKANMILNIIDTIFWFALFIITCMSTAGSCSGSSCPLGGLVATLAIILCGFSGLLSFVCIRDHRYFKANGTLPGMAKPASHGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0B6</accession>
    <name>A0A2I2G0B6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_361973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701634.1">
        <property type="nucleotide sequence ID" value="XM_024844493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0B6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0B6"/>
    <dbReference type="GeneID" id="36552193"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361973"/>
    <dbReference type="OrthoDB" id="4509084at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="93" mass="10645" checksum="2697AD3A08B364CB" modified="2018-02-28" version="1" fragment="single">RKKTPVYIEDISPFNETILVTQQKRFDLGFQRIQMCLLNILGLFTLHRKSALLALQFKHLQISVQKDPRGGPPIPLIELGTDATKRYLGLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0E8</accession>
    <name>A0A2I2G0E8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_477246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701667.1">
        <property type="nucleotide sequence ID" value="XM_024853431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0E8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0E8"/>
    <dbReference type="GeneID" id="36561129"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477246"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42113" checksum="921C72D4BB05B14B" modified="2018-02-28" version="1">MSTTTVSPTTASPLSTAIPTCTTPKPGKNGYLPPEACDVILYYVPSFGAAVFFCVLYGLLMIAHIVQGFMYKKRYTWVIVMGALWELLAFVFRSLQTRQQNNESWATAHTVLFLLAPLWINAFLYMTIGRLIYFLIPDKRLGGITAKRYGQLFVWLDIVAFIVQAVGAIMTTDTQASNAETMHGVHIYMGGIGLQELFILIFSGLAIHLHRRMIVMERIGQLDDEKLHRGRMPWRWLFYAMYTALGMITIRIIFRLAQYADGTNPNNPVLTHEWYEYVWDAAPLFIAIVLMNIFHPGCVLQGPDSEFPKLSRKEKKQIKREKKEAKKTLKESRKKAKLGNGIEFEQLRRQEEGGMGYSDGSYDAVNSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G165</accession>
    <name>A0A2I2G165_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_218076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701923.1">
        <property type="nucleotide sequence ID" value="XM_024842845.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G165"/>
    <dbReference type="GeneID" id="36550544"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_218076"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="252"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="748"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1284" mass="140271" checksum="C125BC3CE20CFEF5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G221</accession>
    <name>A0A2I2G221_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_448653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702234.1">
        <property type="nucleotide sequence ID" value="XM_024850983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G221"/>
    <dbReference type="STRING" id="1392250.A0A2I2G221"/>
    <dbReference type="GeneID" id="36558682"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448653"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000090">
        <property type="entry name" value="Lipoyltransferase and lipoate-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="72"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="442" mass="49242" checksum="74F69A5A0D2998DE" modified="2018-02-28" version="1">MLPLLPSCLRSSSRILSRHGPLPPRRYNSSFPSDQFAQLASRPSARHQIYQSLSTDPYVNLSIEHFLLENAPADSSILFLYINRPCVVIGRNQNPWLETNLHAIHNDRVLREPDDSTSSDVVYVRRRSGGGAVYHDEGNLNYSVISPRTTFTRNKHAEMVVRALHRVGATNTSVNDRHDIVLSSGEDQPRKISGSAFKLTRQRALHHGTCLLDTPNIGRLGFFLRSSARDYIKAKGVESVRSPVTNVSSMFSNALTPFSIQSVVTSVMEEFATLYEVNPDAVRRAQRAHAHDPELYAGEDWVAGAVGDAQGQQEPKIKSGIDELTSLEWKYTQTPQFTFSTYPIEDDPRERPALPSSLPPKTRAFLRLKHGVIIESCISTASEPTLADQQASRVHEALNGRTLHEIQQTHWDEVLLDCLGAEVEATTIHELSKFIGSKLGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2R8</accession>
    <name>A0A2I2G2R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Surfeit locus protein 5 subunit 22 of mediator complex-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_388444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702459.1">
        <property type="nucleotide sequence ID" value="XM_024845843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2R8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2R8"/>
    <dbReference type="GeneID" id="36553542"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_388444"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12894" checksum="2EDE68A7C5DBE3E6" modified="2018-02-28" version="1">MDSQPSSKALHNRINTDVSQLLQRFENIMATATVESTNHTSTAVETYQLDVESTALVRAAEDLLSLSRTMKETWLFGKLDTLGEDEADVKRREELERDAEAIQKAVEDGGLLKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4B9</accession>
    <name>A0A2I2G4B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative importin beta-4 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_385594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703020.1">
        <property type="nucleotide sequence ID" value="XM_024845734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4B9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4B9"/>
    <dbReference type="GeneID" id="36553433"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385594"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121458" checksum="D86A4B4BC3CA89D5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4S4</accession>
    <name>A0A2I2G4S4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_437595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703182.1">
        <property type="nucleotide sequence ID" value="XM_024849405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4S4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4S4"/>
    <dbReference type="GeneID" id="36557104"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437595"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="109"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="593" mass="65542" checksum="80F9F1A7E1770221" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G547</accession>
    <name>A0A2I2G547_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_427156</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703302.1">
        <property type="nucleotide sequence ID" value="XM_024847759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G547"/>
    <dbReference type="STRING" id="1392250.A0A2I2G547"/>
    <dbReference type="GeneID" id="36555458"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427156"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB48000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="501" mass="57288" checksum="DB0B909337AF2702" modified="2018-02-28" version="1">MGQDDEPKTYRYNETPVYTTSNGCPVMDPQASQRVGRNGPLLLQDFHLIDLLAHFDRERIPERVVHAKGAGAYGEFEVIDDISDITVVDMLKGIGKKTKLFTRFSTVGGEKGSPDSARDPRGFAIKFYTEEGNWDWVFNNTPVFFLRDPAKFPIFIHTQKRNPQTNLKDATMFWDYLSTHHEAVHQVMHLFSDRGTPYSYRHMNGYSGHTYKWTKPDGTFNYVQIHCKTDQGNKTFNNEEAGRLASENPDWHTQDLFDAIKRGENPSWTCYVQVLSPEQAEKFRWSVFDLTKVWPQSEVPLRRFGRFTLNRNPENYFAEVEQAAFSPSHMVPGVEPSADPVLQSRLFSYPDTHRHRLGGNYEQIPVNCPMRAFSPWHRDGAMNVSGNYGANPNYPSSFRPLRYEPVKASQEHEQWAGGVVAEQFPVTAEDYVQANGLWQVLGRQPGQQEAFVHNVSGHLCNAHERVRKATYEMFRRVNADLGARLEKATEAIATDAKSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5M8</accession>
    <name>A0A2I2G5M8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703488.1">
        <property type="nucleotide sequence ID" value="XM_024853384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5M8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5M8"/>
    <dbReference type="GeneID" id="36561082"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476827"/>
    <dbReference type="OrthoDB" id="4498251at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="370" mass="42061" checksum="C87741B867D8899F" modified="2018-02-28" version="1">MTDITKFEQFGINTFYNDIPILDNANDWFKWNQKVNGFIRISAVADDGMTPPIEEDEARQWTHRQKFYSAMIMAKLTHNAAQRINAFEISRVHLLIKAVKDNFKPEGTGTYVNLQRRLMSLTREKCGSAQALGAEIRKIHAEKLLLDPDCVTSEIERTYFFMHALGSEYESFRDHIFRQMDLVNERDENGNITKAAPTFDYIENKAIEEEHRKGQLRKQPTEVQALPALAIIRGPGDKKVIPSSDGTTCRIEIDNVPCCSFCRKPYHIDSECFSKNPRLKDRKKEGKGQRSKTGNSNTGTRQPLKRRPSTDDEDDDAGGPRDPKKPTFMATKASGEDVNKAFGKDVEGNLILFDYIPSMMATKTLSIRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G610</accession>
    <name>A0A2I2G610_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_456876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703616.1">
        <property type="nucleotide sequence ID" value="XM_024851657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G610"/>
    <dbReference type="STRING" id="1392250.A0A2I2G610"/>
    <dbReference type="GeneID" id="36559356"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456876"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="281" mass="29460" checksum="9A36350F8A12BB74" modified="2018-02-28" version="1">MSAEEQVQLSNFNSIFSLDGKVAVVTGGSRGLGLHAASGLLQAGCSKVYITSRKAAACDEAVRALNALPNKRPGAVAIAIPADNSRVAELDRLVEEVKKTTDHVDILFANAGATWGEKFETHPEAMFSKVMELNVKSVFYTIQKFAPLLSVNANKEDPSRVLITGSAAGIIPGSLGENATFSYSASKAAALHLARNLALELGPRHILVNAIAPGFYPSKMANGLIELQGGLGAMEDQSPNKRLGRPEDIAGLVVFLASRAGGHFNGAVLVTDGGANLRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G683</accession>
    <name>A0A2I2G683_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703681.1">
        <property type="nucleotide sequence ID" value="XM_024849496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G683"/>
    <dbReference type="GeneID" id="36557195"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438035"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="183" mass="20295" checksum="62635D9CD6D29CD1" modified="2018-02-28" version="1">MNPAPSAHEHTHDSMKSSDPDANYNIIAWGKKREAGTSSIENTNPDVNLAPIAWQRQENNAPSAHEHNHEMSANRVEKTNADALSAPSEWNKRANPPAAHEHAHDMTAHHVEDTNADAKFGGSGWAKKRGMEATMADQHMADHAETVADQAYKVKEWVSDREQKRDVSSKQTSDDWFPLGGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G694</accession>
    <name>A0A2I2G694_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703694.1">
        <property type="nucleotide sequence ID" value="XM_024849499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G694"/>
    <dbReference type="GeneID" id="36557198"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438047"/>
    <dbReference type="OrthoDB" id="5410365at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="279" mass="30825" checksum="8186E5ECBECFE006" modified="2018-02-28" version="1">MSPPATIILKQPLPTDAVSLGRLVQNPQDPSQDYYEPPTPPTDVSTQRLEKFNELLTKTRDTRLHAFLTTIISSSTSFSNEQTTQIDSALCITRQLHNSSDYFRDLCLVPRARRWLEYAITRKFKVYLVVGLKTVTDATVTLREGRSREVAAEAQVPVGAAAASVGVMLPGVVDPGFGVSNARGTASEVGFFAPGEQVYAVQYRRVEFARFSGRKIETSWLESGNRWELYIGSRGAREEGEDREVNGMEVTLGEDTGEEILGGHGEVVALGDEKVYFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6E4</accession>
    <name>A0A2I2G6E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_438068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703735.1">
        <property type="nucleotide sequence ID" value="XM_024849504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6E4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6E4"/>
    <dbReference type="GeneID" id="36557203"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438068"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000082">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="125"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB48433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="423" mass="46121" checksum="8C311547DC7ACBF2" modified="2018-02-28" version="1">MKREDVVYFGAGPAALPTEVLAKAAEALQNYDDTGLGVAEHSHRSSIATDILNTMKADLASFLDIPETHDVLIMQGGGSGQFDATLYNSVAIWVENQRQKILQNGEIAEEDLIQQLRQKVQSELRLDYLVTGSWSAKGSQEAVRLLGADNVNVATDARKINDGKFGKIPEESTWKLSEKPAMVYLCENETVDGVEFPRFPKVLESKAADDQTVVVGDFSSTILSRRIPFEHFSIVFFGAQKNLGLPGITPVIIKKSLLSILSQSKPDILRRVGLPVAPTILDYAVTAKNNSLYNTLSIFDVFVAGQVLKKLLATFPDKVQGQEAVAGKKANLLYEALDAYPDVYKVVPEKSVRSRMNLCFRVTKGGNVDEAEKAFLKGATDRGLLGLKGHRSVGGIRASNYNAIPEAGVEKLVAFLKEFATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6E5</accession>
    <name>A0A2I2G6E5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Conidial pigment biosynthesis oxidase Arb2/brown2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_511049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703758.1">
        <property type="nucleotide sequence ID" value="XM_024854846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6E5"/>
    <dbReference type="SMR" id="A0A2I2G6E5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6E5"/>
    <dbReference type="GeneID" id="36562552"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511049"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042440">
        <property type="term" value="P:pigment metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014111478" evidence="8">
        <location>
            <begin position="23"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="172"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="444"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="612" mass="68564" checksum="CB8B1E58C1AF2AD0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7E7</accession>
    <name>A0A2I2G7E7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_436503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704102.1">
        <property type="nucleotide sequence ID" value="XM_024849171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7E7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7E7"/>
    <dbReference type="GeneID" id="36556870"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436503"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="530" mass="56379" checksum="9142B5CD3D12FD35" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7G6</accession>
    <name>A0A2I2G7G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_494360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704128.1">
        <property type="nucleotide sequence ID" value="XM_024854071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7G6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7G6"/>
    <dbReference type="GeneID" id="36561776"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_494360"/>
    <dbReference type="OrthoDB" id="2522477at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="317" mass="36715" checksum="5983587BFA6FFCA3" modified="2018-02-28" version="1">MSSLDIFPPELLECIISHLPSPDLKSLRLTCHAVNDLATRWVFRRVYICIDSVRNNTIHHEREGFKELVDKYAPFIRDLEVDGGDGNRIESMCPFEVAPFLQPMLFLETLSMTGPTGYWFQAHGGYLMGPFETLMLRASLLTPSAERIFPRLRSLNLCIWEGGDEDWFLDNLGVLFIIPSLENLQLETLVLSHHDPKLPAAFDLDRQRTNLKSLTITNSYINITALEKILSMPRSLTCLQLHHRDSRDYYRPEDWREFSRPPQDLYRAISQQRASLETLAVDWDLESVRGYGLDLSVERFPQLRSYDGTYPDSSRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7J8</accession>
    <name>A0A2I2G7J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sexual differentiation process protein Isp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_446642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704140.1">
        <property type="nucleotide sequence ID" value="XM_024850819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7J8"/>
    <dbReference type="GeneID" id="36558518"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446642"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="745" mass="83781" checksum="C75BEDFBBF70FAD6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G884</accession>
    <name>A0A2I2G884_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_174933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704398.1">
        <property type="nucleotide sequence ID" value="XM_024842632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G884"/>
    <dbReference type="GeneID" id="36550330"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_174933"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="77" mass="8443" checksum="26953FA10FBE73E8" modified="2018-02-28" version="1">MVFIVSLIPSVHAARCGIWYFEIGAGVNAIVWHSVSEDMLLVGYILMLFRQDISSHGCMVFPAACLAMSTSAITDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8G9</accession>
    <name>A0A2I2G8G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_464681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704481.1">
        <property type="nucleotide sequence ID" value="XM_024852268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8G9"/>
    <dbReference type="GeneID" id="36559966"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464681"/>
    <dbReference type="OrthoDB" id="6365728at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="345" mass="39911" checksum="AFFD5B0CD97E4AF2" modified="2018-02-28" version="1">MSVSSLRTDGHVHEPTLPPEAPVSQDTIQKLQEMMESVERSYAGQIKSAARDTTRRLEKSNKSLGVQVNNQRKEIEQAHARIHALMAQIKDLENTLHAKNNQLEKNGEDLSSKDTQVKDLENALHTQSDQLKNNEKDLSSKDDQIKDLENKLCIKDAQLEDLQDDLSSKDAQLEDRQNKLSTKDAQIKTMNNNLTAMYLEIREVERLRIKNANKDQRIEVLQLENANKDQRIGELHTESNDRNQRIGELETEKTNQNQCIEELHAQNVNKSKRIERIEVENTAIKANIRIRISEALENNTALETQLENCRKKLENCEESKRKWKEKARSNARTDGYHSRRHGHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9A8</accession>
    <name>A0A2I2G9A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Snf1 kinase complex beta-subunit Gal83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_384366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704763.1">
        <property type="nucleotide sequence ID" value="XM_024845678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9A8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9A8"/>
    <dbReference type="GeneID" id="36553377"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384366"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="351"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="466" mass="49781" checksum="156D583D8E427D57" modified="2018-02-28" version="1">MGNNPSKGPIGEIPSASSPSTPPASAEKKVTRQPSLNASSGTFKATAVDPSASKENATGHSTSQTQAPAQQRLQSRNPPDSTPRNVPDSKKPQSRSKDIASPDPSNPVQVPVSRAAARRDPYPPVGPSAPPHNTYYSASTHLQRPPRMPLPIGDATTTPGSPIIGPDDSYMGSPPSDPLLEQGAGPRESNLSSTIADDDEMLDDLGPNASTGVGRAVPTIIEWTAPGDKVYVTGTFVNWEKKFRLHRGENPSGVLSAKLNLRPGTHHLKFIVDGEMRASDNLPTAVDFTNHLVNYVEVSADDMNRARSHSDKQSRNAATPGIHPPQAPSDPVGASQDESAVADQAEKEEPEEIPMGDFRGILPQFLVDLDREDETQETPAYQQAVNIIGEAPTPPSLPLFLGKSILNGTTPMKDDSSVLNYPNHTVLNHLATSSIKNDVLATSVTTRYKRKYVTTILYKPTGDITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9E7</accession>
    <name>A0A2I2G9E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_426407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704804.1">
        <property type="nucleotide sequence ID" value="XM_024847706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9E7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9E7"/>
    <dbReference type="GeneID" id="36555405"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426407"/>
    <dbReference type="OrthoDB" id="4153178at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="76177" checksum="6BC569844F7F1A2C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9K0</accession>
    <name>A0A2I2G9K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_384610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704858.1">
        <property type="nucleotide sequence ID" value="XM_024845683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9K0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9K0"/>
    <dbReference type="GeneID" id="36553382"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384610"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014143402" evidence="2">
        <location>
            <begin position="25"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="767" mass="86762" checksum="58E2D8F62B5CC414" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA74</accession>
    <name>A0A2I2GA74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_465082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705065.1">
        <property type="nucleotide sequence ID" value="XM_024852298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA74"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA74"/>
    <dbReference type="GeneID" id="36559996"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465082"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="301" mass="34051" checksum="93AD071E97FDE639" modified="2018-02-28" version="1">MSIAPTTRKIVCFSDFDGTIFMQDSGHVLVDALGCGAEGRQKFEQEIKTGARSFVEVSEDMWGSLKIPFSDGFEIMQTQLDLDPGFKEFHQFCVAHKIDFNVISAGLKPVLAQVLKQFLGPEEASQIEIVANDADIREEGGQWKPIWRHDTPLGHDKARSIQEGRALAEKYALDNEIPLIIFIGDGVSDLPAAREADVLFARKGLRLEEYCKENKIPYIPFEDFSEIKREVQKIMKEDEEKTGGHGVPARFNPRANMWRRISSKQAVPQFIAATPKEEKMMLWPESFSELQAEKIRDKAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAM2</accession>
    <name>A0A2I2GAM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_354148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705227.1">
        <property type="nucleotide sequence ID" value="XM_024844012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAM2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAM2"/>
    <dbReference type="GeneID" id="36551712"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354148"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF79">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="366" mass="42516" checksum="1A8FAF20D8BD1D9F" modified="2018-02-28" version="1">MSSEIRPFKVDIPVEEVDRLQRKLKDTRLPGREIVPDAGDQYGPSYSWAQTIYDAWTTDFDWFSVQAEMNKYPHYITAIEDINIHFLHARADSPRAIPLLMIHGWPGSFWEFSQVWGPLSHPANPEDLAFHVVVPSMPGFCWSDWPPRKGWTLRDNARVFDALMKRLGYEEYMVQCGDWGHFVGRELGARFTDSCKLLHCNFAPSPLPEGVQYTEREREVAGRVEDWLERHMGYAVEMRTRPHTIGIALHDNPLGILMWAGEKYNEAADPDKQKQPFWTKAILTTASLYFFTGCIMPSMLCYYENVRHENFAEFNMRPENRIQVPFGYSSFFWDTEPSSKRAVERTGNLVFYRGMCSLLSWYCHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAS2</accession>
    <name>A0A2I2GAS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor IIIC subunit delta N-term-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_463308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705286.1">
        <property type="nucleotide sequence ID" value="XM_024852163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAS2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAS2"/>
    <dbReference type="GeneID" id="36559861"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463308"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="2">
        <location>
            <begin position="610"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="77497" checksum="A8D88859242BC42F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAX8</accession>
    <name>A0A2I2GAX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_435259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705309.1">
        <property type="nucleotide sequence ID" value="XM_024848901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAX8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAX8"/>
    <dbReference type="GeneID" id="36556600"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435259"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="187"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="418" mass="46583" checksum="0DDC7D331932370A" modified="2018-02-28" version="1">MTTITNTPTKRASIQQKQNAVRSRCLQNPRTFFTDAIPTVLIPPTIFTTLLLGLWTWKCFWIVVMQDKLLYIAWLPPFARSEQIADYEGQCGPVRWEGKQIRSLDGTKLTVCEGRMKSAVGSHVHGHSDATASLRDDLRNSDPTKPKKRVVICYFQGNGGSTPLRLPLLSDMLRTVTSATEDPSVEYIVTALSYRGYWTSSGRATQSGIELDAQAFLAWASRTYAGPDTDLRLVLWGHSLGSAIASTALATDLARRDGRESSVGAPISGLVMEAPTSSTKDMLISLYPQKWLPYRYLWPFLWNNWDSSRAMERMAKWRDECPGMEAEVEEDGDDEKTMAPGLGTVKPRRIHRSLPPILMLSAEKDEVIPPHAVDQLEADARRMGLVLERKDVAGAMHTEALVKVEGKRAVVNFLLSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB40</accession>
    <name>A0A2I2GB40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1446-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_445481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705400.1">
        <property type="nucleotide sequence ID" value="XM_024850713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB40"/>
    <dbReference type="GeneID" id="36558412"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445481"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="494"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="604" mass="66591" checksum="6C5F7FA76EE16FB3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB65</accession>
    <name>A0A2I2GB65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_424539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705420.1">
        <property type="nucleotide sequence ID" value="XM_024847580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB65"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB65"/>
    <dbReference type="GeneID" id="36555279"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424539"/>
    <dbReference type="OrthoDB" id="4368627at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="363" mass="43401" checksum="ECB199B32C9B5D4D" modified="2018-02-28" version="1">MGSLISSSQAETEEEEWNKRVADLENQISLVRQEAAKSRERRKIQKQYRESQEQFREFQEQFRKIQEQHAYKSRQNRLEAQREIQEQRHPEFLEQHQGIQEQCQELEEQQRELEEQYREIKEHYREIREESREIEEQHQKNREKHQEIMERDREIVERYREITERQREIEENKRREMEKKPRDSSGLVTRSSAPHQSRMQNRPGLGKQFANNGDILADALMVTERFKPEDLERILFPKLHGLDAETVLALPCDKCSMSFEALSAMASYLLQNDCKELPEDQERSREGLVALLKEGKYEEAEKQSEILLSEQESEEHLDENSLPTIPEDLERRRATLVVLLQEGRFEEAERLSEAFASQPMAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD76</accession>
    <name>A0A2I2GD76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative toxin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_435950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706079.1">
        <property type="nucleotide sequence ID" value="XM_024849058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD76"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD76"/>
    <dbReference type="GeneID" id="36556757"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435950"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF60">
        <property type="entry name" value="BIOSYNTHESIS PROTEIN (TRI7), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="285"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="426" mass="47393" checksum="66A797CA0405D8D5" modified="2018-02-28" version="1">MSAFDVWRVPVAQWTLMQLVTAMAVGLTPSRSRLRPAVAAVVVALACGFQREITGGAIDVRVAGPMMASCWLNVLNKMDLLVLSRISYDGQVEWEKRAGVKATRSGSLVARILWALGTAFNYRRVNTPWQVRMLPRFGGQGMEDGPERGRFVLVGVGKVVLGVVLLALFTVDTTDPNLLPAIEALPRDESVLLPWVYAASMKRAVLQIAFTISFGICCRAFILAGYNIGAITAVGLGIHHPSAWPPIAGSLFEGWSLRRLWGYVHHFCLSKPARLEEANLLYRISWHQTLRPLLSANADMITSSILRIPRASRWAVYLRLVIAFMLSGLFHSGIDLTFGIAWEDSGALWFFTMQAVGILVESAFQHAFRRWVGALSPVVRRALGFLWVCVFLLWTAPVWMDPMVRSVYVDGTPVFSPFLMFRSWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDD2</accession>
    <name>A0A2I2GDD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_455243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706172.1">
        <property type="nucleotide sequence ID" value="XM_024851513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDD2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDD2"/>
    <dbReference type="GeneID" id="36559212"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455243"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="286" mass="31100" checksum="ED4E729C7FCE7CDB" modified="2018-02-28" version="1">MATSKPAVIICHGSYHSPAPYEPLMEHLRSEGFEAYCPHRPTCNLKELNVGDVDNPDFNRGPPPEGFPSDTKDVDVVVQLLRELIGNGKYVLLMAHSSGGWVATQAAIPELQSKNRRAKGQAGGIIGLFYLGAFVIPVGESVHSFFQPKDGPPVTPPFMRFYEPGVSGVGTIVNAREYLFNDLDAESADRWAATLTASPVMTGVLTNDAYSVLPCAYLVLDNDRTLPKDYQEAMIALQTQSGNVFTVYHAPSGHSPHLSWTEHLVEKVKEFTEAITGISVSAIAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDS3</accession>
    <name>A0A2I2GDS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_355312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706347.1">
        <property type="nucleotide sequence ID" value="XM_024844084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDS3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDS3"/>
    <dbReference type="GeneID" id="36551784"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355312"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="248" mass="28003" checksum="55574E1B0F9EBBF7" modified="2018-02-28" version="1">MKSILFFIPLAQAGTVVWDAFFNESFTVDHFDKWSWSNQIEPFQWYIHGSEETSHYLELSSEFKNPADKADAKGIRISIDDTASWNGQPMMRSELIPQTTADLGSGHLFYHFSLQTREKNAPAAGLEHQIAFFESHFTELQYGGDEKTLRWMADGKSHWSTDLEPGTWYNFAYEIDFDAQTVGLWASDGSAALTQVVKPVSASAQTNSQDWHVGELRLDNGQKGGAEDWYWSGIYIEKGEITKVVSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE23</accession>
    <name>A0A2I2GE23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate-sugar epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_436220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706446.1">
        <property type="nucleotide sequence ID" value="XM_024849115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE23"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE23"/>
    <dbReference type="GeneID" id="36556814"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436220"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="305" mass="34080" checksum="FD6D2283886B9B16" modified="2018-02-28" version="1">MATMNSILVTGATGKQGGSVVRNLLARNAPFQILAVTRNVKSSSALKLAEKSPNITLIEGDLDNPAAIFKSAKERTSNPVWGVFSVQAADPRNDDERRQGIALVDEALKQGVKSFVYSSVDRGGEKRSINNPTPVPHFIYKHEIEKHLMERAKDTEMAWTILRPVAFMENFTPDYFGKVFTTAWQMSLKGKSLQVVATSDIGFFAAEAFMRPDELAGKALSLAGDELTFDQMAEVFERSTGRKVPTTFRLPVWAMMAAVKELGVMFKWFHDEGYGADLVEMRRMNPDLKDFGRWLAEESQFETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE24</accession>
    <name>A0A2I2GE24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_406809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706458.1">
        <property type="nucleotide sequence ID" value="XM_024846649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE24"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE24"/>
    <dbReference type="GeneID" id="36554348"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406809"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="19519" checksum="AB283CB2B3551F5D" modified="2018-02-28" version="1">MPSPDITAKKSRTRSDYVFRQIYRTRWFDNDMYAHLNNTVYAMLFDSIVNTYLIDRCGMDPFSMNNNDKDKSAAPVSNQVAIMVNSYCDYFASVSFPDVLELGLRVAKLGSSSVTYEVGVFKEGEEAVKVVGGYTHVFVARETMRPTRAGMEEGTRRELEKLVVKGIGNGAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEH7</accession>
    <name>A0A2I2GEH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Na+/H+ antiporter Nha1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_425511</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706564.1">
        <property type="nucleotide sequence ID" value="XM_024847639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEH7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEH7"/>
    <dbReference type="GeneID" id="36555338"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425511"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="26"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="459"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="474"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="812"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="613"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="844"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="898"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1047"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1076" mass="118330" checksum="5AECE984CBD66A24" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEW8</accession>
    <name>A0A2I2GEW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_506463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706730.1">
        <property type="nucleotide sequence ID" value="XM_024854393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEW8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEW8"/>
    <dbReference type="GeneID" id="36562099"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506463"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="599" mass="66773" checksum="D0D20F5396BC68D2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG29</accession>
    <name>A0A2I2GG29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_422769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707112.1">
        <property type="nucleotide sequence ID" value="XM_024847462.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GG29"/>
    <dbReference type="GeneID" id="36555161"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422769"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000250">
        <property type="entry name" value="RNA polymerase II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000745">
        <property type="entry name" value="RNA polymerase II transcription elongation factor (Ctr9)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001586">
        <property type="entry name" value="RNA polymerase II transcription elongation factor (Ctr9), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="93"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1473"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1473"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1533"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1607"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1638"/>
            <end position="1647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1680" mass="189483" checksum="0A6BC72818284376" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGD3</accession>
    <name>A0A2I2GGD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L4-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_433851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707250.1">
        <property type="nucleotide sequence ID" value="XM_024848588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGD3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGD3"/>
    <dbReference type="GeneID" id="36556287"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433851"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="280"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="373" mass="40308" checksum="506C1CF86755CDFE" modified="2018-02-28" version="1">MASRPTVTIATADGKASGATYPLPAVFTSPIRPDIVQQVHTGMAKNKRQPYAVSEKAGEQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNQCRSGRMFAPTKVWRKWHQKVNVGQRRFATASALAASSVPALLFARGHRVANIPEVPLVVDSKTFEGAAIAKTKAAVSLLQALGAGAELVKVQKSKKVRAGKGKLRNRRHRQRRGPLVVYNPEVDGKELVRAFRNIPGVETSSVFNLNLLQLAPGGHLGRFIVWTSSAFQSLDQVYGTTSTPAALKKDYLLPQNVVSNADLSRLINSSEIQSVLRAPKGEARTKRAHVQKKNPLRNKQVMLRLNPYAAAFSKEKLGQKSVESAGKPESASKGFLNVLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHA4</accession>
    <name>A0A2I2GHA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_377817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707519.1">
        <property type="nucleotide sequence ID" value="XM_024845419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHA4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHA4"/>
    <dbReference type="GeneID" id="36553119"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_377817"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="71461" checksum="DA13CE84C970190A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHN3</accession>
    <name>A0A2I2GHN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_378130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707691.1">
        <property type="nucleotide sequence ID" value="XM_024845433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHN3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHN3"/>
    <dbReference type="GeneID" id="36553133"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378130"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="414" mass="45853" checksum="F8C36AB7590601A6" modified="2018-02-28" version="1">METDKSQPSSSAPPRSDSLPILIVGAGISGLILAQYLRRSGIAYQIFERDASIAARAGGWGLTLHWALPALYELLPEDVKERLPETFVNKEAVKSGDKGRYQFFDLASGEALCSVPAAERIRVSRSRFRQLLTTGVDVQWSKPLQDVQYHDDSVTVRFEDGTSYQGSIVVACDGSRSRVRRSLYPSNYRNAPLPIQLLGATTRYSVDQATAVRALDPFFFQGTHSESNVYLYFSFLDSPFNFDDSPDGYLCQVVVSWSNDRGVDIPTGTTERIALMKSLTEDWAEPFRSLVHDLPDDADVVPINIEDWMQKQGTNEQPRAVLLGDSAHSMTMFRGEGANNAIVDVLDFTKRVDLQSISKSSSASIHESIRAYEKDMTARAGPSVENSRKACLDAHDFSIIKAGNSPLVARRVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIJ4</accession>
    <name>A0A2I2GIJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_507443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707992.1">
        <property type="nucleotide sequence ID" value="XM_024854486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIJ4"/>
    <dbReference type="GeneID" id="36562192"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507443"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="106" mass="11736" checksum="03D6ECEC1315B0B8" modified="2018-02-28" version="1">MTIPVQTISSLRATFNPFARSSRPCRLLLTLLRNPSTTPASSPTHVDIKVKQLPRLSTQEPEILIGFKGGKEVKLEVGKRNMKIGDVVEEIARVGRAIEREESLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIX7</accession>
    <name>A0A2I2GIX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <ecNumber evidence="5">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_454093</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708138.1">
        <property type="nucleotide sequence ID" value="XM_024851408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIX7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIX7"/>
    <dbReference type="GeneID" id="36559107"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454093"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="419"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="826"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="854"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="928"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB52836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111564" checksum="6496CA58E8D04169" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ68</accession>
    <name>A0A2I2GJ68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative spindle pole body component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_507615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708179.1">
        <property type="nucleotide sequence ID" value="XM_024854499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ68"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ68"/>
    <dbReference type="GeneID" id="36562205"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507615"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="280"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="582"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="966"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1026" mass="115001" checksum="55745B30D7876FFB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKD8</accession>
    <name>A0A2I2GKD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_473213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708646.1">
        <property type="nucleotide sequence ID" value="XM_024853020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKD8"/>
    <dbReference type="GeneID" id="36560718"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473213"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="554" mass="60214" checksum="600F96B53F5609A1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKU6</accession>
    <name>A0A2I2GKU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-methylsalicylic acid synthase</fullName>
            <ecNumber evidence="5">2.3.1.165</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_400784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.165" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708803.1">
        <property type="nucleotide sequence ID" value="XM_024846345.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GKU6"/>
    <dbReference type="GeneID" id="36554044"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400784"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050641">
        <property type="term" value="F:6-methylsalicylic acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="28"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="922"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1691"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="922"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1052"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1664"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="954"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1767" mass="191530" checksum="925810DC69DBC74A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL98</accession>
    <name>A0A2I2GL98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708956.1">
        <property type="nucleotide sequence ID" value="XM_024848045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL98"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL98"/>
    <dbReference type="GeneID" id="36555744"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431481"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="479" mass="53324" checksum="BBD0497DCAE9F8A1" modified="2018-02-28" version="1">MSRPATSALQIPSASTKGENPMSLRQRGPTRSATFAEGSSSLRNERRNSTLSDSVSEARNSIRSSTDDLFFPRAAKQAEVDLPNEESHWHSAPLGLALLPAIAGVFFQNGSAVVTDVTLLVLAAIFLNWSVRLPWDWYRSAQAVRQPDRYYDASEISPVLDPDEAQSTPNPQNNSTTTDPKSHPRSSDAAGAACRELQVHELAALVSCFVFPMIGTWLLHTIRSKLSRPSEGLVSNYNLTIFLLAAEIRPFSHLLKMVQARTLHLQRIVALSTEEEDAKVDISKIIDITKRLEELEAHVSEAAAERLASESSTQSQENTQSVVSQATGELRKGFQPEVDALTRAVRRYEKRTATTNFQTESRFQALQNQVNQAISLAAAANRTDRQRRVGFIPMLFDWMYAAALIPIQLFMSLTALPWQGARWCLRTCQALLMSRPSERPVKGKTPQDRKSRSPRQTRRLIPADQSGSKGLKSIRENKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLE1</accession>
    <name>A0A2I2GLE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_2391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708995.1">
        <property type="nucleotide sequence ID" value="XM_024842942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLE1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLE1"/>
    <dbReference type="GeneID" id="36550641"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_2391"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="238"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="490"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="561" mass="62746" checksum="34B35A402D308B23" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLT8</accession>
    <name>A0A2I2GLT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_431637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709139.1">
        <property type="nucleotide sequence ID" value="XM_024848080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLT8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLT8"/>
    <dbReference type="GeneID" id="36555779"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431637"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF13">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54470" checksum="C9F1122755BB411C" modified="2018-02-28" version="1">MPQQEVYHLHPTGWENDPEEERFKSSTLDYLTACTYNNYALFFRLDDADKSRAVEVLKQGLERMLSQVRHLCGTIEKDPAGGHSFVKKKDSTVRFFVQHLEADEKYPSFDEIEKTNFTAVPLGDLNDWSVSPMTYGEKAEAHPDSSPVVSAFKANFVRGGLVFNMHHHHYSNDVMGWAAYTHQLAEHCKAIINNTSPPPWDATLLDRSRLLKPEPPEEKKVDGPPPPEMHPAHTESVSLLFHLPKSKAAELKKLASPTDGSWISTYDAFSAYIWRTFSRLRAPVFKADLSEPIFWSEAVDMRRRFHSPKVHPRIQGNIMFAAFSPTAPGPQPTLAEVISEWSLPQLASYIRKVTNSVTQEGLDEALGSVALVRDKTSMNIRINSYPPLSILQTDHRDANITAADFGFGTPITYRHLMDCVSQGVLIIYPPRRGGPESDEGPEFSLAYEKSYAQTLIDDPEWNRFFEYRGVDAVDAGWASSVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLX8</accession>
    <name>A0A2I2GLX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709161.1">
        <property type="nucleotide sequence ID" value="XM_024848083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLX8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLX8"/>
    <dbReference type="GeneID" id="36555782"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431644"/>
    <dbReference type="OrthoDB" id="4499634at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="282" mass="32616" checksum="AAE40B28772E93BD" modified="2018-02-28" version="1">MRERSILQLQNQLAYERQKLQDTRDGLLTSLTPPPDDPNLLLNALRDAETHQSTRGIKRSRSESEDLEAFEPTPPEDDLEWTTYCRSGFLLPVTSVYEGTSRKEFNAFKRKLAEHFATTGSFLTNERHMVREALRHVSRRIADKWTIHSQRKGDGSWLEFHSFLDQQFPSTRYTPVYAESLYRNPKQRVNQSVHQFMRYLSCLEAAMPQLFDEAHRSLKLWHGTLPEICQASDLHPNEASFNALVDSLEKAEASLQERVQALGGSIPSRGDSTKKSKKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM25</accession>
    <name>A0A2I2GM25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_504800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709228.1">
        <property type="nucleotide sequence ID" value="XM_024854233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM25"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM25"/>
    <dbReference type="GeneID" id="36561939"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504800"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="658" mass="73625" checksum="CFD4C21A266992C0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMB5</accession>
    <name>A0A2I2GMB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_469489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709319.1">
        <property type="nucleotide sequence ID" value="XM_024852639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMB5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMB5"/>
    <dbReference type="GeneID" id="36560337"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469489"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="489" mass="53508" checksum="EA2F6C2591754EDD" modified="2018-02-28" version="1">MTQTEVQSDKSYGHDWRSSKLFIITVTSFGLFTDMFLFSFIIPILPTILEDRLHQAHSQTQFLTSLALSMNALVSIVIAPITARVADNSPRKNLFMVFSWVLNAIGTVITAWVNTLAGLFIGRIIQTLAGSLIWNVGMAIIADTVGPTNIAKALGFSILFTTGGMLCGPAVSGTLYQYASYSVTWASTFIILLLGIILQLLVVKPCHFEPYTEGYGSDMEQPNTSGLSSPYSGQFYDRNPLLPPTSPRQIPSYQSFPEQQGPEAETNNPTKHQPPSHNVYWLMLCKKRVTMALVADALFAILIASFETTIPIHIKAIFHWETVQAGLLFLLLQVPSFILVLPAGWLKDKIGMRYPVSAGYLLLAPFMWLLGVPGQDGYAWAGSGKAGRIIYITALVGIGIFRVLPLGFGAVEVLNGANELNSEYPGIFGPHGGYSRSFSLSNVTWKLAMFVGPLASAALSDALGYYYLNVFLASLCFLMAICTFIILRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMG1</accession>
    <name>A0A2I2GMG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_397115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709383.1">
        <property type="nucleotide sequence ID" value="XM_024846160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMG1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMG1"/>
    <dbReference type="GeneID" id="36553859"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397115"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="335" mass="37393" checksum="42E263B8265F9A3C" modified="2018-02-28" version="1">MTKITILGAGITGMAIASQLPRHHDITIVARNLPGDEPHSQEWASPWAGAIWAGMDGSTPREQQFQLNALGVWWKLALSDPESGVRRIEMTEYRDSKTLDQIWIRDKVPEFRVIPENERLPGTTVGFKYRTVVLTPMVFLPWLRAKLEATGVKFQRVTVRSLDDLRGMGHDILINAAGIGPLRLEDVKDTRVQEVRGQTVLVKSKFDKLFVRNGDNYTYAFARGDGTTVLGGIKQFGSTETQVDSDIRADIIRRVHESLPEDFPSPDPKDYTIVRDIVGIRPQREGGVRVEKEIVNGQKVVHAYGVAGGGYVFSFGVAKEVARLVDEYESPVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMP7</accession>
    <name>A0A2I2GMP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-x8-C-x5-C-x3-H type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_431792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709446.1">
        <property type="nucleotide sequence ID" value="XM_024848122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMP7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMP7"/>
    <dbReference type="GeneID" id="36555821"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431792"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="517" mass="57978" checksum="FD12A69B2369499A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMQ4</accession>
    <name>A0A2I2GMQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_9102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709459.1">
        <property type="nucleotide sequence ID" value="XM_024855429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMQ4"/>
    <dbReference type="GeneID" id="36563136"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_9102"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="81" mass="8795" checksum="F18902FD377DD74A" modified="2018-02-28" version="1">MATTDETISTGPKVPLDDVTVQNAARTIQRAYRGYRTRSELRGLGLDASTRWAETPNGICSIVPPPHPPLKLTTPPKAKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP38</accession>
    <name>A0A2I2GP38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Lysophospholipase</fullName>
            <ecNumber evidence="3 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_421310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 10"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709940.1">
        <property type="nucleotide sequence ID" value="XM_024847351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP38"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP38"/>
    <dbReference type="GeneID" id="36555050"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421310"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF62">
        <property type="entry name" value="LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013986521" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="47"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB54638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="634" mass="68006" checksum="4DC706505EDC30CE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPM6</accession>
    <name>A0A2I2GPM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_25755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710132.1">
        <property type="nucleotide sequence ID" value="XM_024843059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPM6"/>
    <dbReference type="GeneID" id="36550758"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_25755"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014112908" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12025" checksum="7F37D5F57CC97912" modified="2018-02-28" version="1">MLVVLLLAISLLFGLCSQCHPAEKQRWIQYTAFYLCKGPTSRYLVCIIGLFILEIMWRGISSSHSVGEGSKTRRNTPQYCCYGVIGKAKIMLIVLHTRTGIQICNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPN5</accession>
    <name>A0A2I2GPN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_374222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710125.1">
        <property type="nucleotide sequence ID" value="XM_024845280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPN5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPN5"/>
    <dbReference type="GeneID" id="36552980"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374222"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000414">
        <property type="entry name" value="Putative serine/threonine-protein kinase haspin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000961">
        <property type="entry name" value="Putative serine/threonine-protein kinase haspin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="497"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB54823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="659" mass="73935" checksum="523E3660B718BBFE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPZ8</accession>
    <name>A0A2I2GPZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoplasmic Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_452508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710251.1">
        <property type="nucleotide sequence ID" value="XM_024851280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPZ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPZ8"/>
    <dbReference type="GeneID" id="36558979"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452508"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="408"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="444"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="633"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="743" mass="81817" checksum="B142396E3FC3BBBE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ53</accession>
    <name>A0A2I2GQ53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_421629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710303.1">
        <property type="nucleotide sequence ID" value="XM_024847377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ53"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ53"/>
    <dbReference type="GeneID" id="36555076"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421629"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="34942" checksum="A3994454368D8084" modified="2018-02-28" version="1">MAANSIKLLTGNSHPELAKLVADRLGIELTKIMVLQYSNQETSVTIGESVRDEDVFILQSTRPNDINDGLMELLIMINACKTASARRITAVIPNFPYARQDKKDKSRAPITAKLMANMLQTAGCNHVITMDLHASQIQGFFNVPVDNLYAEPSMLKWIREHLDVNNCVIVSPDAGGAKRATGIADRLDLQFALIHKERPRPNEVSRMVLVGNVKDKVAIIVDDMADTCGTLVKAADTVMQHGAKEVNAIVVHGILSGKAIENVNNSCLSRIVVTNTVPHQDKKELCDKIDTIDISPTLAEACRRTHNGESVSFLFSHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQD3</accession>
    <name>A0A2I2GQD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_505702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710380.1">
        <property type="nucleotide sequence ID" value="XM_024854314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQD3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQD3"/>
    <dbReference type="GeneID" id="36562020"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505702"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="184"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="824"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="880"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="893"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB55078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="970" mass="107017" checksum="DEDE886C88BD5026" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR10</accession>
    <name>A0A2I2GR10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 11">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_432858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 11"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710622.1">
        <property type="nucleotide sequence ID" value="XM_024848352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR10"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR10"/>
    <dbReference type="GeneID" id="36556051"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432858"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="352" mass="36912" checksum="A2EE2D1862FC7C4A" modified="2018-02-28" version="1">MSYQQERFIAELAVQRATLLTQKVFNEKAKGTVSKDDKSPVTIGDFGAQALIIQAIRKNFPNDEIVAEEEASSLREDKALSAEIWRLVSDIKLEDPESDNLLGGPLPSEEAMLDIIDQGKSAGGPKGRVWALDPIDGTKGFLRGGQYAVCLGLIEDGDVKAGAIGCPNLPVDDSAAMTASIGVDQTSGAGNGVLFSAIKGAGSTSRPLTNAGLAESKSISMRPVPNIAEAVFCEGVEAGHSAQGDNAAVAQLLGITAPSVRLDSQAKYCSIARGAGDIYLRLPVKKDYQEKIWDHAAGDLIVREAGGQVTDIYGQTLDFSKGRTLAANKGVVAAPAAVQGQVIDAVKHVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR33</accession>
    <name>A0A2I2GR33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_432880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710640.1">
        <property type="nucleotide sequence ID" value="XM_024848359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR33"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR33"/>
    <dbReference type="GeneID" id="36556058"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432880"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="428" mass="46565" checksum="8E427BD1354100CC" modified="2018-02-28" version="1">MGRSSKDKRDAYYRLAKEQNWRARSAFKLIQIDEQFDLFEHENPEKVTRVVDLCAAPGSWSQVLSRVLIKGESFGRRSWVEKKRKEKEALARASTEGAAQDEEANDDGDAELKPRANVKIVSIDLQPMAPLDGITTLKADITHPSTIPLLLRALDPDAYDSTAASPSALRPPHPVDLVISDGAPDVTGLHDLDIYIQSQLLYSALNLALGVLRPGGKFVAKIFRGRDVDLIYAQLRTVFEKVSVAKPRSSRASSLEAFVVCEGFIPPAIHDGLIGMEALKNPVFGGAAAPRPTSADGNLGQEVMDVDTPSAPNGPTLTTERIVSNDSNQPIETRLLHSDSHASGTPEPLAHKPVAEKFAVENRWIPSFIACGDLSSWDSDASYSLPPDHVSLEPVQPPTAPPYRRALELRKEKGGAYGKTRLGAMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRV5</accession>
    <name>A0A2I2GRV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_433117</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710910.1">
        <property type="nucleotide sequence ID" value="XM_024848411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRV5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRV5"/>
    <dbReference type="GeneID" id="36556110"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433117"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="168"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB55608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="578" mass="63207" checksum="BC45E06C717B09D0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRX8</accession>
    <name>A0A2I2GRX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BSD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_399886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710933.1">
        <property type="nucleotide sequence ID" value="XM_024846297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRX8"/>
    <dbReference type="GeneID" id="36553996"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399886"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="254"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="415" mass="45877" checksum="73BA3181D4ABACED" modified="2018-02-28" version="1">MDIAYDHIQEEIFTSNDTSKKDESKDESAKTDRPNVDLNTELQETFRAFSASPWGARIGGLWDNVRKQGESYYEGARQEYAAASEEAVKGFSDLRETIVGRTRGLSLSTPFAAGSAEKTTDEATTPTASRAGEASGAEGAESSEKGTGAGTDAGEGFLSRFKAEAGRRLKELEKAEEAADEAILRFGQNIGQKLRDAVSIVPPGTDSNKILFESKDSEGKRVIHATRFEAQLHVIHSNLDSFTKDPVSDEWATFQKEFNVDNKTSAIAADLEKYPELRAAMEKLVPEQVEYATFWSRYYFLRLVIETEEQKRKELLKGANVDEEEEVAWDDDSDDETDSPSTPQVKSTKTDEAQSSAPATEKNNLLKPNEPRRSNDQQSQADSESSYDVVSGATSRTPASPKDKTKDDDSDEDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS52</accession>
    <name>A0A2I2GS52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcipressin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_348040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711010.1">
        <property type="nucleotide sequence ID" value="XM_024843663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS52"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS52"/>
    <dbReference type="GeneID" id="36551363"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348040"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="300" mass="32157" checksum="D39256828A5A9309" modified="2018-02-28" version="1">MTGITVSPPGSFPSSPSFGASRASRSSSTSSRRPNLSLDMSNLPTLSQPTPPTNTLLITDLNDLLLFQPDALAAIRAQLESIAPLNSFSPLPSLRRIICSFYSEQDALRIRKLLDGASLLDRSSARAKIYFGEPTPIMDEQGPKLLEAPQLDKLFFISPPPSPPHGWVMRNEDPPNKEVHASDLAHALANLKTEQSGAAGVAGFGGADANANAMEPGTPMSISSDKRTPSWPVAVSQQRSRSSTLIYHPDNHGGSPNLPAVMVEDTSASVEDADVEMSPIEMPVKKMPPKTTRPPVELME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSG8</accession>
    <name>A0A2I2GSG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_372118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711119.1">
        <property type="nucleotide sequence ID" value="XM_024845193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSG8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSG8"/>
    <dbReference type="GeneID" id="36552893"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_372118"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="42"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="223" mass="24354" checksum="07B254FD8C94B93F" modified="2018-02-28" version="1">MSNSNDTSGASSSTPFEEGAFLPGGHNTDPQLAEDSPTANYKLNHLMLRIRDPKRSLHFYVDLMGMRTVFTMNTGPFTLYYLGYPPTATDRADLAAWASKASNPRNLAQTLGLLELCHVHGSESAPDCQVSTGNVPPHLGFAHVGFTVPDVPAAVARLRAEGVSIFKELGDSSRESVPLSQWEADRGVGLGEIHPNYKRFFDQIAYVLDPDGYIVELISQNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQB8</accession>
    <name>A0A2I2FQB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_280087</name>
        <name evidence="1" type="ORF">P170DRAFT_371632</name>
        <name evidence="3" type="ORF">P170DRAFT_491143</name>
        <name evidence="2" type="ORF">P170DRAFT_493763</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000033">
        <property type="protein sequence ID" value="PLB42754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000031">
        <property type="protein sequence ID" value="PLB42767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000025">
        <property type="protein sequence ID" value="PLB42807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_280087"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371632"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_491143"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_493763"/>
    <dbReference type="OrthoDB" id="3470073at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="118" mass="13283" checksum="0796F8F344E20482" modified="2018-02-28" version="1">MLDSLVRVSRRVVYNHYASVRAEARSSVQAGSIAPPAIRCPEGHYIPGAFDLPPKPTLARPRGSTPARMPAEPRGRVWSQALPFQQFHVLFNSLFKVLFIFRSLYLCAIGLRPVFSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQY4</accession>
    <name>A0A2I2FQY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_78374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_78374"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="160" mass="17791" checksum="7F11CCD9ABCBB02A" modified="2018-02-28" version="1">MLDSLVRVSRRVVYNHYASVRAEARSSVQAGSIAPPAIRCPKGTTFRGPLTCRPNRRWPAHGEVHRHECRLNPAGESGRKRFPFNNFTCFLTLFSKCFSSFDHSTCALSVSGQYLALDEIYHPFRAAFPTTRLVEGASHGRGHPVPDGILTLYDGPFQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRQ1</accession>
    <name>A0A2I2FRQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_481251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698605.1">
        <property type="nucleotide sequence ID" value="XM_024853847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRQ1"/>
    <dbReference type="GeneID" id="36561545"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_481251"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="102" mass="11918" checksum="EAB7089726A7271D" modified="2018-02-28" version="1">MYLRDCSLRYRFLSTCNETIFFRVQETAWGYELQHTGVVRHEYSVASDGSPSVRQYMFFLGLQAHVAHTTVINVPPINLRQRLILSRRSDKFNINDAFGDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT01</accession>
    <name>A0A2I2FT01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">COPII-coated vesicle protein SurF4/Erv29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_418001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699019.1">
        <property type="nucleotide sequence ID" value="XM_024847188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT01"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT01"/>
    <dbReference type="GeneID" id="36554887"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418001"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="303" mass="34210" checksum="682091CA1F57E769" modified="2018-02-28" version="1">MAQIRGTAGYNLGHQNPFQGPGRADATDDPSPLDAIREQTSKIEDWLDTMSDPVKPYLPAIGRFLIVVTFIEDSLRILTQWSDQLLYLRDYRKIPWGITHSFLIVNVIAMSICSFLVVARRHTEIAVAGLLGVVVTQGLGYGLIFDLNFFLRNLSVVGGLLMVISDSWVRKKFVPAGLPQLDEKDRKMYVQFAGRVLLIFLFVGFVFSGQWTMWRIIVSLTGFVACVMVIVGFKAKWSAIMLVVLLSIFNVLVNNFWTLHPHHPHKDFAKYDFFQILSIVGGLLLLINMGPGQLSMDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTD6</accession>
    <name>A0A2I2FTD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_441288</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699139.1">
        <property type="nucleotide sequence ID" value="XM_024850281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTD6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTD6"/>
    <dbReference type="GeneID" id="36557980"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441288"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="353"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB43837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="699" mass="74564" checksum="F66C073D0829C7AB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTF4</accession>
    <name>A0A2I2FTF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_368658</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699230.1">
        <property type="nucleotide sequence ID" value="XM_024844873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTF4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTF4"/>
    <dbReference type="GeneID" id="36552573"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368658"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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            <position position="349"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
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            <position position="356"/>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
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    <sequence length="449" mass="48678" checksum="315BDBD1B4B2C035" modified="2018-02-28" version="1">MAAPAQTFKVADISLAAFGRREIELAEIEMPGLMAIRSRYAADQPLKGARIAGCLHMTIQTAVLIETLTALGAEVTWTSCNIFSTQDHAAAAIAAAGVPVFAWKGETDEEYTWCLEQQLKSFKDGKKLNLILDDGGDLTSLVHDKYPEQLKDCFGLSEETTTGVHHLYRMLKEGKLLVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKIAVVAGYGDVGKGCASALHSMGARVLVTEIDPINALQAAVQGYEVTTMDKAASQGQIFVTTTGCRDILVGRHFEAMRNDAIVCNIGHFDIEIDVAWLKANAKSVQNIKPQVDRFTMPSGRNIILLAEGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKAEDAAFGQKYVEFGSAGKKAVGVYVLPKVLDEQVALLHLEHVNGELTKLTPVQADYLSLDVTGPFKAEHYRY</sequence>
</entry>
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    <accession>A0A2I2FTF8</accession>
    <name>A0A2I2FTF8_9EURO</name>
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                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
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                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 23096</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="919" mass="99623" checksum="2BD6319FCDADA16F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">R3H domain protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_67958"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
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    <dbReference type="InterPro" id="IPR024771">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="262"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="326"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="82944" checksum="3DB949BB02D96FDA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTV3</accession>
    <name>A0A2I2FTV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase 21.3 kDa subunit</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699380.1">
        <property type="nucleotide sequence ID" value="XM_024844902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTV3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTV3"/>
    <dbReference type="GeneID" id="36552602"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369404"/>
    <dbReference type="OrthoDB" id="2093493at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="193" mass="20921" checksum="FFC0387C9CCBF86A" modified="2018-02-28" version="1">MARGFLNAAKSASNVIAVHKKYTVQSVGVWERLRRIFSIEPNRSTGVPLNSQFRLPTPGALPPLTYDDPVTVPAGDIADNPYWKRDVRRSYPRLSTVNQADAVGLLSVGSQAAPKDDVLQVGEAGEKQLVSVKQQGEERGLAGLFEKDGKGIKNVLGVNGLPPMPCNLNSSASKYQLGDDHGYPDVYPCRTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV23</accession>
    <name>A0A2I2FV23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_287515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699797.1">
        <property type="nucleotide sequence ID" value="XM_024843216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV23"/>
    <dbReference type="GeneID" id="36550915"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_287515"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="158" mass="18066" checksum="4B846FA860A4080E" modified="2018-02-28" version="1">MWLTEVISAWLRLRINRAGCHWPIQSSNWSVLLTENEPSMTALGSRISSDMPTSTEWRRETVPTVGKHRNQFPGLQMMNHDRVYIHDLFLVSLCETIGAGLRMRTIDFIVTTIRSVWSCDKSRHEWRCRGWCCGAGPDEVITRAGCLKRPEVGLGHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVS3</accession>
    <name>A0A2I2FVS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative rRNA maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_458415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700019.1">
        <property type="nucleotide sequence ID" value="XM_024851798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVS3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVS3"/>
    <dbReference type="GeneID" id="36559496"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458415"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="887"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="834"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="910" mass="103480" checksum="1831A32BA04D8BB2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVT3</accession>
    <name>A0A2I2FVT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_266469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700055.1">
        <property type="nucleotide sequence ID" value="XM_024843118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVT3"/>
    <dbReference type="GeneID" id="36550817"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_266469"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="13995" checksum="095D3542D151DE8F" modified="2018-02-28" version="1">MPLSSVSFVSPIPSVYSGPLLSRRLISPCRLFPVLYFMMAVLVPVGGPVFCTLPHLLVLFFSFFFFFTFNHGCVCSSHLSVPLSFFVLLVVSPVSLLSLVCMYGTYRSLIPDKMYAIVTSTRVQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVW3</accession>
    <name>A0A2I2FVW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_440003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700057.1">
        <property type="nucleotide sequence ID" value="XM_024849969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVW3"/>
    <dbReference type="GeneID" id="36557668"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440003"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="55" mass="5975" checksum="D550726B85B8E748" modified="2018-02-28" version="1">MRAYSGCGTSIVSTVACKAPSADRIQKKRGRSTWNSDSYSELGPVFYQGDSQPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW94</accession>
    <name>A0A2I2FW94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_440118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700212.1">
        <property type="nucleotide sequence ID" value="XM_024849997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW94"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW94"/>
    <dbReference type="GeneID" id="36557696"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440118"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="565" mass="62455" checksum="D37A426BBDEAE674" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX05</accession>
    <name>A0A2I2FX05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_366175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700466.1">
        <property type="nucleotide sequence ID" value="XM_024844748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX05"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX05"/>
    <dbReference type="GeneID" id="36552448"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366175"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="266" mass="29027" checksum="5644701F4BF7B6C2" modified="2018-02-28" version="1">MASPAPNLYSFPNNDELAKQLRPYVLRNQNAALSRHETFRIAVSGGSLPTVLAKALLAPGNGTPEDTAQFSSWDIFFADERAVPLDHEDSNYRLLKDELLSKIPAELGTPRVHTIDPAHVNDEDPQELADLYQEELMRIFASKDSVKLPVFDLILLGCGPDGHTCSLFPGHELLREKDSWVAAISDSPKPPPKRITLTLPVVTHAVNVAFVATGGGKKEIMKQIFDAEEGRSLPSALINQGAGEKVSWFTDHAAVDGVAFPRRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXH3</accession>
    <name>A0A2I2FXH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">pectin lyase</fullName>
            <ecNumber evidence="13">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_279276</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700615.1">
        <property type="nucleotide sequence ID" value="XM_024843183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXH3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXH3"/>
    <dbReference type="GeneID" id="36550882"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_279276"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF67">
        <property type="entry name" value="PECTIN LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014137953" description="pectin lyase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="17">
        <location>
            <begin position="100"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB45313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="490" mass="50657" checksum="3F428D7A4B49C17E" modified="2018-02-28" version="1">MAFLRSLLTATALLGVSAQAKGVVGTPFGFASGTTGGGDAAAAAPSDLAELKSWLSDDTPRVILIDKEFNFIGSEDTCTDCQCCIPDSNSCGSSGQNAIKTDGSDWCGDYPTTKCTYDNAGLEGLEVASHKSIVGVGSAGVLRGKGLRLTSGVNNVIIQNLHITELNPQYIWGGDAITLDGTNNIWIDHVKVNLVGRQMFVSGYKSSGSVTISNSEFDGRTSWSASCDGHHYWSVLGYGKGDQVTFANNYIHHTSGRSPKLEFNSHWHAYNNYWTKNSGHAFDVGENTNALIEGNVFESVKTPFEDDSNPGSTFAASSSDASTCTSKLGRACVPNVLTDSGKLSASDESVLSGWPTGEGNVTVKPASKVSSYVLAHAGIGKLGSSASATATVGGSAAATSGAVPSSSAAASSSSVAKRFAPDSGAQSEAGPWGTPFPTPSNVSWGWKTITVPVPIPTGTPSGFPAGQPSPAPTGESESKHKFPFFGAFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXH5</accession>
    <name>A0A2I2FXH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_280047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700640.1">
        <property type="nucleotide sequence ID" value="XM_024843187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXH5"/>
    <dbReference type="GeneID" id="36550886"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_280047"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="183" mass="20109" checksum="5AAEA83F1FF3EB35" modified="2018-02-28" version="1">MAECGRTCRPQARRGDGPIRRPGRAMVPWKELHNPCSIRLPPVALPRSLRMYAANPPSFTLFINPPWDSNSLCPALFPPFPSFSIQIFQRGDWAETLQIHAQSSRSPKQATPLPVGSLDHTTNRATRAASKCKSPNGLASVVCWKVARAPLKYYPIRNNSELRPLADLSPDFPPAPAAGFSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXZ3</accession>
    <name>A0A2I2FXZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall integrity signaling protein Lsp1/Pil1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_439253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700806.1">
        <property type="nucleotide sequence ID" value="XM_024849800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXZ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXZ3"/>
    <dbReference type="GeneID" id="36557499"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439253"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="350" mass="39471" checksum="5262C9EE2060DE20" modified="2018-02-28" version="1">MHRTYSMRQSRVPTASQIENPPPPLSTTKTGRWMGKGGFAGHAFRKNAAGAFGPDLARKLSQLVKMEKNVMRSMELVAKERMETAQQLSIWGENCDEDVSDVTDKIGVLLYEIGELEDLYVDRYDQYRVTIKSIRNIEASVQPSRDRKQKITDEIAKLKYKDPNSPRIVVLEQELVRAEAESLVAEAQLSNITREKLKAAFQYQFDALREHSEKVAIIAGYGKHLLDLIDDTPVTPGETRTAYDGYDASKGVIQDCEEALSNWVTSKASVKSSLSTRTRTLSQRQRDSVAKNREGVDLSGQDQPLRGDRDSWLPADQHQTYHDVEDGEEVTSTLDGEPRGREEEREPVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYJ3</accession>
    <name>A0A2I2FYJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LPXTG-motif cell wall anchor domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_363959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 23096</strain>
        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Nybo J."/>
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</entry>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZK7</accession>
    <name>A0A2I2FZK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_414892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701361.1">
        <property type="nucleotide sequence ID" value="XM_024847037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZK7"/>
    <dbReference type="GeneID" id="36554736"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414892"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="26"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="526" mass="55768" checksum="6AE9884ADAEFE0C0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZY2</accession>
    <name>A0A2I2FZY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatidylserine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_449705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701504.1">
        <property type="nucleotide sequence ID" value="XM_024851063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZY2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZY2"/>
    <dbReference type="GeneID" id="36558762"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449705"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF13">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="405" mass="45844" checksum="5E9EEBEC83A14E40" modified="2018-02-28" version="1">MSTPYKPKEPIVRDLSDYIYRTEERTKAFNDAVASAIAPENGGADEMKEQGIANLDNYIQWVDELLRWVPRVNTTGDELLTRILVFYWVFDQPSLRGLQTEIQPQNSNTDLSWLSYWLVTFAREQGSFMNSPQSAAAVYSFYINDKYKPEAPEWAEPKTGWLSFNHWFAREWKDIDVARPLDGKDDDNIIVSVADSMYDGSWPVDNGDVVITIDAKSVQWPINKLLQTTGTTFTGGNFMHAFLGPTDYHRQHAPVTGEVIEVRNIQDQVYLQVAKKKGGGLRGDRGLTRDLAELQKREAKPGKQFFALDAPDDAGYQWCQTRGLIIIQTKKYGKVAVLPIGMAQVSSVVFTVQKGDHVEKGQNISYFQFGGSDVVVVFENRVKFDGDLRPGETKLNVRKQFATFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G023</accession>
    <name>A0A2I2G023_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2 type zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_479147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701533.1">
        <property type="nucleotide sequence ID" value="XM_024853634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G023"/>
    <dbReference type="STRING" id="1392250.A0A2I2G023"/>
    <dbReference type="GeneID" id="36561332"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479147"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="97984" checksum="36C731CBA445CF70" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0J9</accession>
    <name>A0A2I2G0J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_511170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701695.1">
        <property type="nucleotide sequence ID" value="XM_024854858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0J9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0J9"/>
    <dbReference type="GeneID" id="36562564"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511170"/>
    <dbReference type="OrthoDB" id="4472286at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18555" checksum="43FA981611507FB0" modified="2018-02-28" version="1">MPYLWKDLIPYGRYHNLEHFLGPIAPSRRQFYAGFIENATASSCYDADEDDHSPLKGTIFPRLTSLTLCVDLIGYYVPRIQASRLRILDIDPRHEPTKPVIVLGAEMMEEVMEQIPDIFPDVEELRFIDTADLTHDIARMLRERLPKLKVLDLSMCGITHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G125</accession>
    <name>A0A2I2G125_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_477463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20366"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701885.1">
        <property type="nucleotide sequence ID" value="XM_024853467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G125"/>
    <dbReference type="STRING" id="1392250.A0A2I2G125"/>
    <dbReference type="GeneID" id="36561165"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477463"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="222" mass="25175" checksum="ADBE3899C1609E98" modified="2018-02-28" version="1">MDVEAELMFDDIAKNYEANFAEDPSLHRVIDQALGLLSPHSQVLDVGCGTGKPVSYRLAEAGHDVTGIDISQNMIDIATRQVKAQFIKTDMTNYEPKMKLDAIFAIFSLFNISRAQVQYMVSRFYDWLKPGGRLVLATIPSECLFQDPGIYDESGEWVDQKPMYFMGHNFCGSAATKRGWEDLFTQTGFEVEDQFSYNFSPPSLDAHKKDPDHLYYVVRRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G220</accession>
    <name>A0A2I2G220_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_438616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702216.1">
        <property type="nucleotide sequence ID" value="XM_024849641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G220"/>
    <dbReference type="STRING" id="1392250.A0A2I2G220"/>
    <dbReference type="GeneID" id="36557340"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438616"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="119" mass="13492" checksum="9739B25688208EA8" modified="2018-02-28" version="1">MVKKRANNGRNKNGRGHVKPVRCSNCARCVPKDKAIKRFTIRNMVESAAIRDISDASVFTDYAVPKMYLKLQYCVSCAIHGKIVRVRSREGRRNRAPPPRIRYNKDGKKLAPPQANKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G243</accession>
    <name>A0A2I2G243_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_438640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702243.1">
        <property type="nucleotide sequence ID" value="XM_024849650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G243"/>
    <dbReference type="STRING" id="1392250.A0A2I2G243"/>
    <dbReference type="GeneID" id="36557349"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438640"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="193" mass="21711" checksum="2C6D3ACB7DEE5149" modified="2018-02-28" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDNKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKMDLRHDPKTNEELNKTSQKPVSPEQGEEVRKKIGAYKYLECSARTNEGVREVFEAATRAALLTKAHKSKKKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2A4</accession>
    <name>A0A2I2G2A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">P170DRAFT_448698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2A4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2A4"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448698"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000002">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000010">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB47004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="379" mass="40600" checksum="DE3022EBF8BB3588" modified="2018-02-28" version="1">MSLQAIKYHDGNLAILDQLQLPYVEKYLTIHTSEDGWHAIKEMRVRGAPAIAIVAALALASELSALMTSSQLPSETEGTRELISGRLHYLVSSRPTAVNLSDAARKLEAVVADSVEKPDSTSYSVASSYIKSAEEMLAKDLEDNRMIGKYGADWIMENAITTLESKATVLTHCNTGSLATSGYGTALGVIRALASKDVLEHAYCTETRPYNQGSRLTAFELVHDNLPATLVTDSMAAALFAGVEKGVNAVIVGADRVAANGDTANKIGTYGLAVLARYHGVKFLVAAPLTTIDLATRSGKDIVIEERPASEVAQIRGPCKESDSNGNLRLETVCIAAKGIQIWNPAFDVTPCELIDGIITEKGVIEKGSDDQFRLGDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2D4</accession>
    <name>A0A2I2G2D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_511705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702355.1">
        <property type="nucleotide sequence ID" value="XM_024854917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2D4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2D4"/>
    <dbReference type="GeneID" id="36562623"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511705"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="182"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="308" mass="32512" checksum="F036797B20DAEBB8" modified="2018-02-28" version="1">MPPSSHQSITPTNHLRFDPWTTSSTGHQVADSAQGTAYRTLRQEKLARQFGEGRGDCTVARGAGGKLERGMWVEGASGSGSARSGQRDIRGMFGVGKASSSSSSSSSASVSKGLSSKEEMKDGLEESSSIITSTNDYNNTNDTNDNTSAIHLQNHTTTAAAAAAAATPSTIPSTLQPQPQPQHPQIFTTLTIYINAASHPCVSDHKLKHLLTLHGATVFLSLSRRVTHVIVGRPNTRPSSKGAGTGAGGGLAGGKLQREIARGGCRGWKVVFVEWVLESIKAGKRLSEARFAMQMAEKGQRSVLGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2R3</accession>
    <name>A0A2I2G2R3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_448837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702464.1">
        <property type="nucleotide sequence ID" value="XM_024850998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2R3"/>
    <dbReference type="GeneID" id="36558697"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448837"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46460" checksum="C9A7DEBD4B3E64CC" modified="2018-02-28" version="1">MARLSGQICSWVTGFHPDSHPSRLDGGFMNGSYNVCQKFVFDDGTIWILRLPRARSVAPEYADEKVAMEVEALRLIREKTSIPVPEVYAWGLARENTLGLGPFILMSFINGICLNDLFNIDFDHIGSLPMPTTNFPAPKRPLTWKMHEILRVGGVSTSEYFQCVNNQDWQQLRFQPNSIAGPRSARILNPRIINHTYENGPFKLICDDFGLGNVIVRSKDDLTITGVVDMEWVYAGPAQLFGSAPWWLLLDRPVTEEWDFEEEEAPKATDRYFTCLEIFIRVLEEEEEKTAESDRKELTELVKWSKDSGAMWLHMLLSSGFFDTPTFPYMQLRNHKGAEWWDERMQEHRDAEDAEKFVADKLDDLAAYDKINDRVEHLKVLMDNKEISTDDFICTVSSLLNSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2V3</accession>
    <name>A0A2I2G2V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_478066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702507.1">
        <property type="nucleotide sequence ID" value="XM_024853524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2V3"/>
    <dbReference type="GeneID" id="36561222"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478066"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="51" mass="5506" checksum="40BCBB752E806A5C" modified="2018-02-28" version="1">MPDLSTFNPTTDLPDLDGKTIFITGETAGLGASTALQLARKRASRISKLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G364</accession>
    <name>A0A2I2G364_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702625.1">
        <property type="nucleotide sequence ID" value="XM_024849740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G364"/>
    <dbReference type="GeneID" id="36557439"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439011"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="78" mass="8405" checksum="C5D5E9E0504F3776" modified="2018-02-28" version="1">MFQALNPLTCATVCSVVYGVYFAQHLVDSRASPPGFAYLELSAADTFFIGPWHAFICHLDQSADSQANGNPLDLLVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3R3</accession>
    <name>A0A2I2G3R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_447473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702817.1">
        <property type="nucleotide sequence ID" value="XM_024850878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3R3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3R3"/>
    <dbReference type="GeneID" id="36558577"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447473"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="362" mass="40051" checksum="6151DE5E0308F748" modified="2018-02-28" version="1">MDFHLRCNSLKCRSPLKERAVVTTCSHIFCLKCADTLGLSHPTTNERHCPACHTLLVNPDDAVATVLNPTEDYKTSVLSGLDPNTIMECAGRALLFWTYQTTQEIVYQEFLAKTLTDKYATINTHMDKVIHNANTEISSLQTRLSDMQASQEQLQKKNQELVDLYRDKCKKLTQITNLYNLLKSRAMRSQMQTAASDTVSSALNTMGRSGNRPPVSAPTTLLAASVPLQTPASFPQNTFPVNQDGVEQIHRHQRSGTGSSKKARAAVAAMPPPGRPLGITRNRDMPNATPQHRTRLTGPSRPSTSTSHLQDSVLFERFRADPNAKKSPPNQHVIPDRGRARGQSFDQAGPAGTRTFFDSSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G552</accession>
    <name>A0A2I2G552_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_361337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703309.1">
        <property type="nucleotide sequence ID" value="XM_024844464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G552"/>
    <dbReference type="STRING" id="1392250.A0A2I2G552"/>
    <dbReference type="GeneID" id="36552164"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361337"/>
    <dbReference type="OrthoDB" id="5278208at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="730" mass="82040" checksum="8A1285FEF9045838" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G574</accession>
    <name>A0A2I2G574_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase 299 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_437738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703332.1">
        <property type="nucleotide sequence ID" value="XM_024849434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G574"/>
    <dbReference type="STRING" id="1392250.A0A2I2G574"/>
    <dbReference type="GeneID" id="36557133"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437738"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27313" checksum="575A826A137BBD2F" modified="2018-02-28" version="1">MRSTLRLLANVKSPRYLEPFAPTGLTGLVTHPSPRPTLIYLYTTTLQKLKAFPESSVYRQSTEALTRHRLEIVEATKPPGFDAWLERVKKTVGAEPARFASLRRQDGSYAAFQKDDGSDNPRGEEWDGESIEATTEGPTRTAEQEARWEKAIDESTKPEDKETDFFPEAMKWENEPALEAQQVSDIEHKIAAGLIEEVIQVAESEMKLVDEMYKSQVWEELAEKPSPGQWTYFERNTSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6A8</accession>
    <name>A0A2I2G6A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_497721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703695.1">
        <property type="nucleotide sequence ID" value="XM_024854118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6A8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6A8"/>
    <dbReference type="GeneID" id="36561823"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_497721"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB48393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="650" mass="74428" checksum="ACD970FF1B44CF86" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6X8</accession>
    <name>A0A2I2G6X8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_407300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703933.1">
        <property type="nucleotide sequence ID" value="XM_024846674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6X8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6X8"/>
    <dbReference type="GeneID" id="36554373"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407300"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1273" mass="142379" checksum="615610A26207F9D6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6Y3</accession>
    <name>A0A2I2G6Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_425672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703936.1">
        <property type="nucleotide sequence ID" value="XM_024847656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6Y3"/>
    <dbReference type="GeneID" id="36555355"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425672"/>
    <dbReference type="OrthoDB" id="10352108at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="168" mass="19011" checksum="597FCC838444D09D" modified="2018-02-28" version="1">MSALEIFVDRNALTDHEQEERKIWKVLEHCPDEELCDDDFVLIDINLYLDQTVPLNGLGSLAKAIGVELRDGQIVEDAPSTKNGLPCSVIVMAFELYAPTNLTDNEIQQRALSIAIDAILPFEKDEFDPPIEYPYETKDFCLYLARDARMNTGLEDGFCRCTIKGEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7D0</accession>
    <name>A0A2I2G7D0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704063.1">
        <property type="nucleotide sequence ID" value="XM_024853222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7D0"/>
    <dbReference type="GeneID" id="36560920"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475103"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014154590" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="107" mass="11570" checksum="321B765F98DD0AED" modified="2018-02-28" version="1">MPLDIFVPTLLGVVIASMVDTACFEKNSPSGFAILNWEGVRANDPDILLDGILVGVDVVQTEEGLSLLFSERIDLLADAFLQFFVAQLVAVMRGLDNGLFAENSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7F4</accession>
    <name>A0A2I2G7F4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_436499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704090.1">
        <property type="nucleotide sequence ID" value="XM_024849168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7F4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7F4"/>
    <dbReference type="GeneID" id="36556867"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436499"/>
    <dbReference type="OrthoDB" id="8300246at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047869">
        <property type="entry name" value="YdcJ_bac-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="436" mass="48267" checksum="C914D4C30A4C8C75" modified="2018-02-28" version="1">MRISSDRLTLERHGAIRLGTPFELRTIKRIFAILGMHPVGYYDLSIAGLPMHATCFRPTDVTSLERNPFRVFTTLLRPELLASHEARELSLSLLGQRKIFSHGLFDILDVAESQGGRLNARQAETFIPEALATFGWQSIAAATLDQYEILKAEHPILADIVCFQNAHINHLTPRTLDITAVQSAMKAAGMAAKSQIEGPPPRKCPILLRQTSFLALEEPVQLWQSKLPGTGSDLNGDLQMFDPKATLIQGSHKARFGEIEQRGAAVTPKGRDLYDKLLQQSRNVSVGLSPEEADARTIEVFQKYPDSWKDLRQQGLIYCQFRCIKPIHTTPAIDKEEGLILDQLISRGVVEAVPITYEDFLPLSAAGIFQSNLQTNTHSPGASVGPMYSLSDQKGLGQALEGTVLNLDDWYADVQRQSLERVAKALGFALEDLMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G803</accession>
    <name>A0A2I2G803_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_357539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704319.1">
        <property type="nucleotide sequence ID" value="XM_024844222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G803"/>
    <dbReference type="STRING" id="1392250.A0A2I2G803"/>
    <dbReference type="GeneID" id="36551922"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357539"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="223"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="440" mass="48495" checksum="073B7BB9F3F10F67" modified="2018-02-28" version="1">MLQHPLRDSARPLTGGRRKSAEADLDIVSLEPALFIPPCANKPAVFRGSCIVNVHEKLPVKRLTVNLRGVSHVKWSYGRNEMRTFTDCKMVLLGPETKMQDNACGIESSDCDLNGCHAGQEHGRLWNPFQKKFHPSGARKMGSKHQVLSPGIHEYGFEMVLPPQLPESICVRGSNVQYNVEACIERPGRLSHPITQNMPIVAVHCPEDDFLEDAEPVYISRNWRHLLHCEVTLSRRGAALGDQLPVVVSLEELGNAKLQGLKIFLSENTQYLQRNGLQSCLGPFKRVLLHDATSDSLSTSSPQPEAQDDSTGSSDDSTSSEEDWSSDATEKPGVADERKLEINLSLPKAIALTHAESDGKLNMHFDTKYQNVQVSHWLEFEFTLSRHGSTGSSDVLKTARAPFVLRSCYAHPANASLPSYDSESDGPTYMTVSAAELGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G817</accession>
    <name>A0A2I2G817_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_464581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704328.1">
        <property type="nucleotide sequence ID" value="XM_024852260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G817"/>
    <dbReference type="STRING" id="1392250.A0A2I2G817"/>
    <dbReference type="GeneID" id="36559958"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464581"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="755" mass="83651" checksum="D2FBE412B5A97EB6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G821</accession>
    <name>A0A2I2G821_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_407966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704332.1">
        <property type="nucleotide sequence ID" value="XM_024846708.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G821"/>
    <dbReference type="GeneID" id="36554407"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407966"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="13"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="938"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2421"/>
            <end position="2498"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="938"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="970"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2509" mass="273146" checksum="02C958E36BCF163F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8V9</accession>
    <name>A0A2I2G8V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_179998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704616.1">
        <property type="nucleotide sequence ID" value="XM_024842662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8V9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8V9"/>
    <dbReference type="GeneID" id="36550360"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_179998"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF8">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32385" checksum="7363BAC16C4AD830" modified="2018-02-28" version="1">MSFLPDRLLHWVYGLPAPSTKRHEPMQVLAVGISRSGTDSLREALHILGYKHTYHGFDSILPPSSLEATYRLLQKKYTTSPTSSQGTNMKLTTSDFDTVFGHCVGISDLPAAEFAPELIAAYPEAKVILNTRRDLDAWYRSMEQTMGYFDANPVDWDWVKSWFDADLFWTRHAMCRTLMPRFFRGSFRSNGKWVYEGHVAMVRGLGLGEDRLLEWSVEDGWEPLCKFLGKEVPSREFPSGNPPREWVERIARTMEGHHRRAVRNLVVFGAVVGVVVAMLVVYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8X3</accession>
    <name>A0A2I2G8X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_475629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704631.1">
        <property type="nucleotide sequence ID" value="XM_024853279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8X3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8X3"/>
    <dbReference type="GeneID" id="36560977"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475629"/>
    <dbReference type="OrthoDB" id="4338954at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="60" mass="7039" checksum="E526C51ECD862F7D" modified="2018-02-28" version="1">MAVIALGFGAANLYTNQQQRHEMAQEEFERLQRNRQLMDAYGEKDNLHDIERALAVYEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8X9</accession>
    <name>A0A2I2G8X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_181953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704636.1">
        <property type="nucleotide sequence ID" value="XM_024842664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8X9"/>
    <dbReference type="GeneID" id="36550362"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_181953"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="207" mass="22985" checksum="0095FFFB614EEF48" modified="2018-02-28" version="1">MQLRRMQMILPDWLQACGLYLVWNDLRQIRNPGVSVCPRCGIPASGSPSHRLQAAVEDVVQVGIPYPGPPDSRPITQASRDVTAHTDAVQVQTKAQKQAILTRRCLRRLTLYGAYRVDMPIPDTPAFDYTPAMRGIVERILAANELARGQSSEHLDQYKKQCAEIGHAMDTVKGVGSVSHNYDPFSSSNDIFGSRQDLVKEVGLVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Z8</accession>
    <name>A0A2I2G9Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_409284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705006.1">
        <property type="nucleotide sequence ID" value="XM_024846768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Z8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Z8"/>
    <dbReference type="GeneID" id="36554467"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409284"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="580" mass="65747" checksum="9E5D3771E908CCBF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA16</accession>
    <name>A0A2I2GA16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_426589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705022.1">
        <property type="nucleotide sequence ID" value="XM_024847720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA16"/>
    <dbReference type="GeneID" id="36555419"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426589"/>
    <dbReference type="OrthoDB" id="4508521at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="102" mass="9894" checksum="79F833960AAE7D8B" modified="2018-02-28" version="1">MSANRSLKVGNVTGDGGRATGYQAIRLGPASYQQPSGSGGASGGDGAEISFATSGQYHNVEAGDISSNGGDAQLQGRNSYSRTGIVTSGKAAAGGAGKITIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA59</accession>
    <name>A0A2I2GA59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_357704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705061.1">
        <property type="nucleotide sequence ID" value="XM_024844236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA59"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA59"/>
    <dbReference type="GeneID" id="36551936"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357704"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="17704" checksum="286420D9B92A40EC" modified="2018-02-28" version="1">MPVADEFESANATYAASFTKGNLQLPPKRKVAILTCMDARIADPAKALGLSEGDAHVIRNAGGRASDALRSIIISQQLLGTREIVIIHHTNCGMLTFSDDQLRSQIRTQLGQDADHIAFLPFKDLRQSVLDDVAFLKKSELVLDVPVTGFVYEVESGRVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAW7</accession>
    <name>A0A2I2GAW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_134604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705299.1">
        <property type="nucleotide sequence ID" value="XM_024842436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAW7"/>
    <dbReference type="GeneID" id="36550132"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_134604"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="106" mass="11743" checksum="FAF4493F10370D25" modified="2018-02-28" version="1">MRDLRSTHTLDPQTARITDIHTHIIPNPISSPRTVYHSRTPIIPSSPLHPILRTPPPDERAPNSNRQGVAHFPSHSSESSCVAVSWSPSRTTGSAVTRRVRQTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBD6</accession>
    <name>A0A2I2GBD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis, uroporphyrinogen III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_508403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705486.1">
        <property type="nucleotide sequence ID" value="XM_024854569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBD6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBD6"/>
    <dbReference type="GeneID" id="36562275"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508403"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="186"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="342" mass="36626" checksum="9986EFE986CC2330" modified="2018-02-28" version="1">MTNSPFSFASSPATPILLLKTKSSPADGYEEFFSAHNYNPAFIPVLEHHFHEPNLRSVRLLFESGALNPGPGRKYGGLIFTSQRAVEGFAKLVDELDDSITSPASHSLPLYTVGPATSRSLTTLRDAHLPHATIHGAETGNGEALAHFILQHYPAFHSSGPSSDTAGNTAAAGGGSNGYGDDAQLPLLFLVGEQRRDIIPKTLMGAEPGRRIGVDELVVYETGVMGSFEREFGEAVGAARGYLDGDADGQGKRAVWVVVFSPTGCDAMVRVLEKQRQRGGQGEEEGGGKRLEGIFVATIGPTTRDHLRKLGFEVDVCAERPSQEGVGEGIERFMDKWRGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBF7</accession>
    <name>A0A2I2GBF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_454803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705520.1">
        <property type="nucleotide sequence ID" value="XM_024851476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBF7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBF7"/>
    <dbReference type="GeneID" id="36559175"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454803"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="329" mass="35677" checksum="5CB753911DDC6BC8" modified="2018-02-28" version="1">MGGSFPGFLYRQLTFCPKPLPSTVNLQGQTAIVTGGNVGLGLEAAKQLTARGLSRLIIAVRTVSKGETAREEILRENPSSGCEIGVWQLDQESFESMQAFGERARALDRLDIVILSAGVKMLEYSKSKTGHETHVQVNHLGTALLSLLLLAPLQKTATERGSAPRLTIVTSEVHFWSKLPEKDAPNMLSRLDDPDSFGSGMDRYNTSKLLNVLWLRELSRRTGPDVVVNGVNPGLCASSLHRSDSTPGKEQFNKVFAWSPAQGGHCLVDAAVRHQDDRGAYISEQTVKKPSPLVLSKEGEKAQVELWDETIALLKEAVPGVDLLGGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBQ2</accession>
    <name>A0A2I2GBQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_492047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705608.1">
        <property type="nucleotide sequence ID" value="XM_024854027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBQ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBQ2"/>
    <dbReference type="GeneID" id="36561731"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_492047"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="32"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="365"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="685"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1237" mass="135199" checksum="FD75174D5E77996D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBV2</accession>
    <name>A0A2I2GBV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dynactin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_405365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705664.1">
        <property type="nucleotide sequence ID" value="XM_024846581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBV2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBV2"/>
    <dbReference type="GeneID" id="36554280"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405365"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="491" mass="52142" checksum="9074F8A2456F9703" modified="2018-02-28" version="1">MAFNKKYAGLPDLDLAPDIYETPDLTDEASTVPTTTVRTASNLDDDAGSNSDIDRQGVDADAARAHFLGATVDAREANFSDSIDTKRKAYRSKGRRIRRNENGLEEVDDLSDSEDESLDRKLARLRREVEELKDEMATREDAAESQDPAANGKEPLGDGVLELSRALDNLYASSRGPGGDGVPHSAAAALSKKLDPSSIPTDQSSAAPATTTTTPNAQQTLTSSPSSATNVGVLSHAAAFDSRLALIESAMGISSASNPFVTDGISEPALQPVLPALDHITSRLATLMNLLVGPAPASAFPTTSAGHLPPSTTVSTPHLETLSTRVRRLTADTEALAAARKRALDAAKAAQNARIAAAALEPSDVSVSSSSATETDPAATQRDEQATKIQALYATLPTIQSLHPILPSVLERLRSLRAIHAGAANASETLDELERRQADMAREIEQWREGLRVVEEKMGQGEAALKSNVELVEPWVRDLEGRLEKLDHAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC24</accession>
    <name>A0A2I2GC24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_143829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705735.1">
        <property type="nucleotide sequence ID" value="XM_024842486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC24"/>
    <dbReference type="GeneID" id="36550183"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_143829"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="168" mass="18611" checksum="241284CC4F9F92D9" modified="2018-02-28" version="1">MEQDRRIMTGRLVSKTSPSARAGCPEIGATQTREAEARQWSNDAGRPLGYGSHGNRRHQITLHTTTPPSPTRQNGGGEQREKRQEEKGKEHIDSLITSALTSDALGGSVLSTFSAPGIFVPPHSLFFPVSDYRLTDGVVRCYHLGQRTHETRRNCSSSIRTKRTKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC25</accession>
    <name>A0A2I2GC25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_143848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705742.1">
        <property type="nucleotide sequence ID" value="XM_024842487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC25"/>
    <dbReference type="GeneID" id="36550184"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_143848"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="82" mass="9250" checksum="B9E3CDE3BC9A989B" modified="2018-02-28" version="1">MECLSTPSEWPCRVFFSLSRLNHRFQMPKYSMPCDARQCNCLGPPSQHGPDDSGCILHAVIHSSYLGFFFLYHSALPDVVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCB5</accession>
    <name>A0A2I2GCB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_435716</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705825.1">
        <property type="nucleotide sequence ID" value="XM_024849004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCB5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCB5"/>
    <dbReference type="GeneID" id="36556703"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435716"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="11">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="256" mass="28978" checksum="D39397ABD1E95F1E" modified="2018-02-28" version="1">MERRDFPEAPEDHQPGDINDLFDYDVGLDELVLQEPPPSSNTNAPKPSFTPEASGLKLGLDEEVKVTRKRQPVAKLDDNRLLSQAGIPKLRRTAKQKLKFKGKGHEFSDAARLLNFYQLWLDDLFPRAKFVDGLAIIEKLGHSKRLQNMRREWIEEEKPQLQADDAQNEQTITMPGSSKSIQPHLRGDDAQPGFSNHPAPHEPQQGSENCTNAQLPWPRIDFDHELFVSSSNNVPHAPDQDAPDDELEALLNEQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCF1</accession>
    <name>A0A2I2GCF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_405703</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705829.1">
        <property type="nucleotide sequence ID" value="XM_024846596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCF1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCF1"/>
    <dbReference type="GeneID" id="36554295"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405703"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="134" mass="15378" checksum="64F8704C227696B9" modified="2018-02-28" version="1">MPVFQAKTFRRATTASSSLGERIGAAYRTSLPRHPFLLFGLPFVMIIVAGSFALTPAAALRYERYDRKVKQLSQEEAMDLGLKGPDGEEGIKRNPRRRVIGDEREEYYRLMAKDLDDWEQKRVQRFKGEPDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEB4</accession>
    <name>A0A2I2GEB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_446341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706515.1">
        <property type="nucleotide sequence ID" value="XM_024850785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEB4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEB4"/>
    <dbReference type="GeneID" id="36558484"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446341"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="55"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="363" mass="41020" checksum="7FEF31F6E3AADFCE" modified="2018-02-28" version="1">MSPLSPTQIQALLERPAVSPPPGQASNLDDPPNLLIFGRTIILLAWILSSMLILIRVYTKIVVVRKFRMSDYAMLLAWGLFMGYLVMGWKINELAPGVDQWNIRLRDFIKMYYYFHIDSIIYGIIIFFIKLSILLQYLEIFSVQRDFFFWACHGLIWVNFVFYAIRTFLEIFACRYLSETGGMLRIDGACPIETMLISIVSSAINSASDIIILILIQIRIWRLHMTLHKKSSVSVVFLFGLLATVASILGVAYTVFIYTKTNNSYNSWCAGVWTVIEIACGIIAGCLPSFSRFLRNISQSAFISELGGFLHNMVSSSSSKRRKDPDVDVDKTRRVPDQYPLASFAPGTQLSLSSTVAADSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEM9</accession>
    <name>A0A2I2GEM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_474876</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706636.1">
        <property type="nucleotide sequence ID" value="XM_024853192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEM9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEM9"/>
    <dbReference type="GeneID" id="36560890"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474876"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF14">
        <property type="entry name" value="BETA-GLUCOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014143403" description="beta-glucosidase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="17">
        <location>
            <begin position="693"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="182"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB51334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="779" mass="82296" checksum="AA1A71CE6D2B1DC7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFK0</accession>
    <name>A0A2I2GFK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706956.1">
        <property type="nucleotide sequence ID" value="XM_024852855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFK0"/>
    <dbReference type="GeneID" id="36560553"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471583"/>
    <dbReference type="OrthoDB" id="4488390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="628" mass="69671" checksum="F3507DD812999B42" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFS5</accession>
    <name>A0A2I2GFS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_349658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707027.1">
        <property type="nucleotide sequence ID" value="XM_024843753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFS5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFS5"/>
    <dbReference type="GeneID" id="36551453"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349658"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000013">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="303" mass="33802" checksum="F0A1017AC5E252EB" modified="2018-02-28" version="1">MTARQTSPTSDHSHSDNNVRKRVCKACDRCRLKKSKCDGGNPCGRCKADNAICVFGERKKAHDKVYPKGYVEMLEQQQAWLVHALQDLYRRASEGEGWPGELLKCEPNGHPLTHDVLTRLGVLDRQKGEHFEENPDVMQQELWKQNAGHMQRQDSSDGSSETAQSPVVPSRFSDAFSRPLPPSPTTFSPSSRTQGPTIKSEPQMTPNNPAYVAPLAMQGVVNPVALQAPQQWSNNSFAPYDEMDLMATPDYANFAFDDPISSPMFNRQVPMNCMVSSSYMDTKNDYEDISQFLNANAPEIAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFS7</accession>
    <name>A0A2I2GFS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">P170DRAFT_401183</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707040.1">
        <property type="nucleotide sequence ID" value="XM_024846360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFS7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFS7"/>
    <dbReference type="GeneID" id="36554059"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401183"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 26" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="25">
        <location>
            <begin position="6"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PLB51738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="857" mass="96023" checksum="8F82E01D57EBEFC6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG45</accession>
    <name>A0A2I2GG45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_461983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707161.1">
        <property type="nucleotide sequence ID" value="XM_024852076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG45"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG45"/>
    <dbReference type="GeneID" id="36559774"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461983"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="584" mass="64228" checksum="7E2B550E742B3A09" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGB8</accession>
    <name>A0A2I2GGB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_453495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707227.1">
        <property type="nucleotide sequence ID" value="XM_024851364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGB8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGB8"/>
    <dbReference type="GeneID" id="36559063"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453495"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF37">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38603" checksum="C39A84D014785462" modified="2018-02-28" version="1">MDTDPPTESISLRNEEMRALVGYFLLDACHSVVLQRTGSMPWSPFIESCAAKLSQECEFPTDRYLLGQVQVQHMLVRIDSLVARGVGENKAPVDIEVMISSLQSDFEACKARLPVPMDHDAFQGIPSHAFEIHLYQTIFFDVYPSSAASFDQSMALLRIDALCHGLAAAKQFMSFYFSLPPGIEKRFSYLQWTMTGFSVAASCKLVLASLEPSVRDHEQVRGLRETLDMRHEIQKSVKRMNTLDQECKGGKWDQHEMFFYQDWLQLLSEWFEEKYRLAQSDSAGVKNGALGVFTTGISEHHVYEEPQPDPGFPWVDLQDVTIEEMLNAWLGPMNIPHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGN7</accession>
    <name>A0A2I2GGN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA polymerase III transcription factor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_377486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707340.1">
        <property type="nucleotide sequence ID" value="XM_024845401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGN7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGN7"/>
    <dbReference type="GeneID" id="36553101"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_377486"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="202"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="637" mass="70579" checksum="11FFF15C3989E48D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHH4</accession>
    <name>A0A2I2GHH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminopimelate epimerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707627.1">
        <property type="nucleotide sequence ID" value="XM_024848647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHH4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHH4"/>
    <dbReference type="GeneID" id="36556346"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434113"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="302" mass="33056" checksum="E7A3C4F97BA6831C" modified="2018-02-28" version="1">MFLNYVVVDVFTTTRFKGNPLAIVQVPANYWSSLSQEAKQLIAVEFNLSETIFLHEPPEDSQDPTESVSVDIFTPKCEIPFAGHPTIGSAAYIFQNYPRAANGGLKELVTKAGRIPVSQDLNTSLVSASIPFDYHLHQTPVLSSLAVSGAAPVTSIVKGMTFVLAELRDLDCLKDVSAGLVEDCIRPQGLDEGWNHGLMATKYYVDLGKNEQGCRQLRTRMFVSWEDPGTGSASSALSCFLALEEPKEQGSGPFEYHIVQGVEIGRRNDIFVRVSRSVDGERITEVLLRGTSVLVSEGRITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHV4</accession>
    <name>A0A2I2GHV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_104182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707729.1">
        <property type="nucleotide sequence ID" value="XM_024842282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHV4"/>
    <dbReference type="GeneID" id="36549977"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_104182"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="103" mass="11878" checksum="ABFFA72F26C9D47D" modified="2018-02-28" version="1">MGRTIFFNLAHFRSRPVIPGLTRYYGVDIQLSYSILILITIFFCSIRALGTQCFGTGSAPFRVFLFATRHCCRYPSFLAEEYYRHPSPVRLDFPRELSTVAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI13</accession>
    <name>A0A2I2GI13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_402763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707825.1">
        <property type="nucleotide sequence ID" value="XM_024846442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI13"/>
    <dbReference type="GeneID" id="36554141"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402763"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32314" checksum="956760B021027AF3" modified="2018-02-28" version="1">MLPSLPDNWISLPILLILAYKNLPFVWLIRFLRTLLTRLFILPTHQNLQPNHLFLPAIHRTRSPLSECDYNIHKSNSTYFTDLDISRGNLSLLLFSQGLSFRLCETKAVMILSGVQCLFRREIRPYQGYEVWSRVMSWDEKWVFVVSHFVERGVFKEGGRVLQGDDISVSISTSGSGSGGKSEGIGKDDAQKKVFASAVSRYVFKQGRRTFPPREMLVKCGLLPKGDGESEEDRKLMEDIEQRRRRDLEAAQLKMGWEAVHNSFDGDVSRVLGRYTDLLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIU6</accession>
    <name>A0A2I2GIU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative high-affinity hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_378949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708104.1">
        <property type="nucleotide sequence ID" value="XM_024845468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIU6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIU6"/>
    <dbReference type="GeneID" id="36553167"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378949"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014197739" evidence="9">
        <location>
            <begin position="17"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB52802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="500" mass="54802" checksum="44AC6DAB6D1E7377" modified="2018-02-28" version="1">MAFLLVTLCCVFATLGSFLFGYDSGVISSTLEQTAFLDRFNHPSDAATGGIVASYNGGAILGSVFASYLSDPFGRRPVMFVGGILASLGAALQAGAMTVAMLIAGRLIAGMAIGLMSSIIPVYCSEVSPPRIRGFLGSMQQWMIGLGVVVAQWTGYGCSLHHTGDFTWRFPLALQAVPSVILVGGVWFLPESPRWLIEKGRTEKGREVLARLHLNRDHSNADLIALEFAEISESIAEEQRRSVRSWRQLLCTRATWRRRVLLACGLQAFTQCSGTNVIQNYNPGLYKTLGLKDPTPLMIQGIWGALAQFWNCVFMLFIDRVPRRRLLIPSLLGMGITMCVEAALAQANDGFSDPSTNPNAVRAAIAMFFVFSFFFTSVGLISWIYQSEIFPTAIRARGSSLATATNWSLNLVFAQCSPIARTSIGFNYFYCFFAFNWAAAVIVWAFYPETAGKTLEEVEQVFSSEPQESRLNIAPSNAEGDWTSKGGYRSEDFTLVAPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIX3</accession>
    <name>A0A2I2GIX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_454088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708132.1">
        <property type="nucleotide sequence ID" value="XM_024851407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIX3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIX3"/>
    <dbReference type="GeneID" id="36559106"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454088"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="513" mass="55758" checksum="708EC2AD9BDB6142" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJF2</accession>
    <name>A0A2I2GJF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708311.1">
        <property type="nucleotide sequence ID" value="XM_024848781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJF2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJF2"/>
    <dbReference type="GeneID" id="36556480"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434731"/>
    <dbReference type="OrthoDB" id="5341924at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116834" checksum="2E07B904A3C20B60" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJG3</accession>
    <name>A0A2I2GJG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_444844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708289.1">
        <property type="nucleotide sequence ID" value="XM_024850663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJG3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJG3"/>
    <dbReference type="GeneID" id="36558362"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444844"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="942"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="853"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="890"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129485" checksum="72223BEBBA31410D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJH4</accession>
    <name>A0A2I2GJH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_423796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708316.1">
        <property type="nucleotide sequence ID" value="XM_024847528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJH4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJH4"/>
    <dbReference type="GeneID" id="36555227"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423796"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="263" mass="28200" checksum="FB21283714F778CD" modified="2018-02-28" version="1">MDSLTTHPSNAQQARAFTSPASLSFPGGAGDLTPPSDKDGNMAVGAQGANGNVNGQQPGANAVNGNGVTPATPAATPAANAPGSGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHNFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFELIYPVLSDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJX4</accession>
    <name>A0A2I2GJX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_507877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708483.1">
        <property type="nucleotide sequence ID" value="XM_024854515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJX4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJX4"/>
    <dbReference type="GeneID" id="36562221"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507877"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="290"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="427" mass="46236" checksum="D5129C39B7D5FA72" modified="2018-02-28" version="1">MDPYDSDSSFEDEGDFTDTGVLLGYASEELIEDTISHIGGRPTWIDDATPPPGEFANCKVCNNPMLLLLELHGDLPDHFPDNERRLYIFGCPRKPCNKKPGSIRALRATKKLKSHPASRKVEKPEPPKEEKKPEAPKQDLGASLFGSTSLTGSVSANANPFSSSSGPAPTGNNPFAVPAATPTAPAAEPNKPSPSQPASESLAETFADKVRVSSPPPTAKTPESSGPSAPWPSESAFPKPYKHFYLDAEYETLSRPSTPTIPENVTIDNTEEETGGGSGELKDALESQLDKAFMKFSTRLGHNPEQILRYEFRGTPILYSYNDAVGKLLHDPQHGAPGHVTVAGNGALRIPRCEYCGSARVFELQLVPHAISILEEDREVGMGEKDDAGMEWGTIILGVCGKDCAPEQVGLTGWREEWAGVQWEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKA9</accession>
    <name>A0A2I2GKA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_490385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708617.1">
        <property type="nucleotide sequence ID" value="XM_024853993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKA9"/>
    <dbReference type="GeneID" id="36561694"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_490385"/>
    <dbReference type="OrthoDB" id="5350472at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="189" mass="21312" checksum="D1D201DCD1540509" modified="2018-02-28" version="1" fragment="single">LPDLLGHFLSRISPAPIEARKRNFYRPSTALFGNWCGVLSYLVKQHFKPKIYQCTWDDQGNFYLNASRGGVSTTAGIGFWMAALDRARYGIVRFPLLRLGNGSKPGDRLSEDGQLGRNGLYLQTTTLCITQIPFARCTKTYPIRRILMGKDAQEVFDLHNLTLSSEYMPGYLCLSKLFYGIPASTARFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKC5</accession>
    <name>A0A2I2GKC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_490433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708637.1">
        <property type="nucleotide sequence ID" value="XM_024853995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKC5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKC5"/>
    <dbReference type="GeneID" id="36561696"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_490433"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF83">
        <property type="entry name" value="DEHYDROGENASE (CYTOCHROME), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="502" mass="54458" checksum="B58F1CEE792A2931" modified="2018-02-28" version="1">MQRMIQGHQAVQLVYKRSTQLSRNRQPIQFIHKIQCHGVRRDNANFPKDQGLSSSWSLAAFGAGVVGSQKPVAKYADQETMLKGVRAISDALGPESVTTDSDDISFHSYSDVSTSHCAARPVAVVTPKSTQEVSVIARICSDYRIPMIPFAGGSSVEGNFTAPYSGISINFSQMNKIIAFHEDDTDVVIQPGVNWVDLNDRIKESGLFLPMDPSPTALIGGMVATNCSGTNAVRYVVLADGSVIKTRHRPRKASAGYNLNALFTGSEGTLGMITEITLKLAPVPETQSAAVATFPSVRDAVSCTTKTMRQGIPVAAVELMDEVQMQVINKNGGAGGRIWEEKPMLMFKFSGTEQSVSAHIERVEMMISQAGGSAFEFARTEKEMHNLWSARKEAVWAMCAQWPEGTRIWSTDVAVPLSSLSVIIDLSKTESSSLGLFSSVLGHVGDGNFHQAVMYDPSDSSQAHGVQECVRKMVHRAVEMEGTVSVCCLPEAFLLALTDWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKE4</accession>
    <name>A0A2I2GKE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">P170DRAFT_507993</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708629.1">
        <property type="nucleotide sequence ID" value="XM_024854523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKE4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKE4"/>
    <dbReference type="GeneID" id="36562229"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507993"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000233">
        <property type="entry name" value="Probable glucan endo-1,3-beta-glucosidase eglC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190681" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="19"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="311"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="327"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="22">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PLB53327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="504" mass="50362" checksum="DC2423CFA9410044" modified="2018-02-28" version="1">MQLNNLLALALSLAVAEAAHKGFNYGAAKSDGSSKVQADFEAEFKTAKNLEDASGFNSARLYTMIQGGTTNDPISAIPAAIKEKTSLLLGLWASGGGMDNEIAALKNAIEKYGDDFTKLVVGISVGSEDLYRNSYDGVQAEAGVGIGPDELAGYIKKVRSVISGTSLSKASIGHVDTWTAWTNGSNSAVVDAVDWLGFDGYPFFQNTMDNSISDAKKLFDESVEKTKSVAGDKEVWITETGWPVSGDKQNLAIANPENAKKFWDEVGCPLFDEVNTWWYILQDAAPTTPNPSFGIVGSDLSEKPLFDLKCSNKNSTSSGSGSGSGSSGSSSSSGSKNSDSSSSGSSGSSSGHGSSSSGSSGSSSSGSSSSGSAASSASGSVTASSSAAASSGYRGHSGRPPYGFGKGGYNFTHGYNSTHPRPSKTSSFHSASTSGSSGSGSGSGSGSGSGSGSGSGSGSGSGSDSASGTGSTPSSSITPSSGAASLSSSIFGAAVAVGAFVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKE5</accession>
    <name>A0A2I2GKE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_454437</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708652.1">
        <property type="nucleotide sequence ID" value="XM_024851435.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GKE5"/>
    <dbReference type="GeneID" id="36559134"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454437"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1235"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1384"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="123"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="794"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB53350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1409" mass="157520" checksum="B1EC149432EAF8AC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKP9</accession>
    <name>A0A2I2GKP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_351746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708760.1">
        <property type="nucleotide sequence ID" value="XM_024843889.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GKP9"/>
    <dbReference type="GeneID" id="36551589"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351746"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="7"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="928"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2262"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="928"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2348" mass="251216" checksum="3023EB87A7B46D64" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLB5</accession>
    <name>A0A2I2GLB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_1451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708951.1">
        <property type="nucleotide sequence ID" value="XM_024842494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLB5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLB5"/>
    <dbReference type="GeneID" id="36550191"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_1451"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41610" checksum="6EA36564A01D07A2" modified="2018-02-28" version="1">MLDTQAVIRSHLILYPTLNMSSDKKPHISPNSFLHAFSTAPSEPSEAPLIVYFITGNPGLIGYYHTFLSLLSEKTKSSFIGQDKERSFQIYGHSLAGFELPEPEQKEQKPESEPHYYDLEEQIRFAQSKIHDFAVDRTNGIDHLSPPSDTAPPTRPKVILIGHSVGAYIAMEVLRRHREGSKSDFPVDFDVIGGAMLFPTIVDIAKSPSGQKLTKLLSIIPQLALVAGIFVRILTALVPASILRSLIRIYMPSAPDTMVDTTAGFLKSKRGVQQALHMAADEMQTITMDKWSDDVWGISTSQEPTSRLFFYFGRNDHWVAERTRDEIIEVRGQVPGGPKMIVCEDGVPHAFCLRHSDFMASKVADIIMDIARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLF8</accession>
    <name>A0A2I2GLF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_469205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709013.1">
        <property type="nucleotide sequence ID" value="XM_024852604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLF8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLF8"/>
    <dbReference type="GeneID" id="36560302"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469205"/>
    <dbReference type="OrthoDB" id="4510210at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="657" mass="74262" checksum="A895FAB1741807FD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLJ2</accession>
    <name>A0A2I2GLJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709045.1">
        <property type="nucleotide sequence ID" value="XM_024848065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLJ2"/>
    <dbReference type="GeneID" id="36555764"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431557"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="67" mass="6957" checksum="F33A5AA47145A8F4" modified="2018-02-28" version="1">MGPGQALGPGTGDKVSGTFDGAWLTRPGRGTRYMESRTGEAKPPALTACHSGRSRPQPQVSTGMRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM53</accession>
    <name>A0A2I2GM53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_420746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709259.1">
        <property type="nucleotide sequence ID" value="XM_024847318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM53"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM53"/>
    <dbReference type="GeneID" id="36555017"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420746"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="525" mass="60457" checksum="E23F75F71CFE92E5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMR4</accession>
    <name>A0A2I2GMR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">1,4-alpha-D-glucan glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_9306</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709490.1">
        <property type="nucleotide sequence ID" value="XM_024855436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMR4"/>
    <dbReference type="SMR" id="A0A2I2GMR4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMR4"/>
    <dbReference type="GeneID" id="36563143"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_9306"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF231">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014165644" description="alpha-amylase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="16">
        <location>
            <begin position="523"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB54188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="630" mass="68836" checksum="D0373A2F823EED03" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMZ9</accession>
    <name>A0A2I2GMZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_482723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709557.1">
        <property type="nucleotide sequence ID" value="XM_024853890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMZ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMZ9"/>
    <dbReference type="GeneID" id="36561588"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_482723"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="613" mass="67596" checksum="3B7A20924B7844F8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN17</accession>
    <name>A0A2I2GN17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tropomyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_397459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709552.1">
        <property type="nucleotide sequence ID" value="XM_024846177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN17"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN17"/>
    <dbReference type="GeneID" id="36553876"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397459"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000114">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="154" mass="17919" checksum="A0C8DEC7FE0D3BBD" modified="2018-02-28" version="1">MNTLRLEADDAQAKVEELKTKVRTLEQENLAKEQEITSLNHRNQLLEGEVEKLESNVKEAKEAATQSAQHDTQNEALQRRLQLLEEEAEEADRNLRETNEKLRQTDVKAGHYERKVQALESSRDQWESKYEEMAKKHAELQKDLHDLEVSISNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN50</accession>
    <name>A0A2I2GN50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_452089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709598.1">
        <property type="nucleotide sequence ID" value="XM_024851244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN50"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN50"/>
    <dbReference type="GeneID" id="36558943"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452089"/>
    <dbReference type="OrthoDB" id="5384020at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="281" mass="29196" checksum="3EC857B331E38D44" modified="2018-02-28" version="1">MSDDRSTSPISVPSSSGRQRRASLASSFTDYLSKSANPGSTSGSSTGPMASAVANAQSNQGRRLSITTLGLSGSPTQTSSLGGRNFRQGSVSSSAGSNSANYEDAVTEDGENGFSGATPNSPFARRVSFGAHALRDARAGSISNGKYPPSERALAGRRRQTASPASGTPSSVNACTGSLAASIDKVASQNERSNSSGRPLGEGFNWSEALRSRAERAPSFGAVSPNAPSNHHAAYGGQSAHHQRAASIASMEQPARELPKQPRQNKPDFFQEKILRGDFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNM6</accession>
    <name>A0A2I2GNM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_432137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709793.1">
        <property type="nucleotide sequence ID" value="XM_024848196.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GNM6"/>
    <dbReference type="GeneID" id="36555895"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432137"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000009">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="541"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="690"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="838"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1623"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1623"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1662"/>
            <end position="1673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1679" mass="191126" checksum="05933A658FA0BB80" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNM7</accession>
    <name>A0A2I2GNM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_432113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709772.1">
        <property type="nucleotide sequence ID" value="XM_024848190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNM7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNM7"/>
    <dbReference type="GeneID" id="36555889"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432113"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="182" mass="20491" checksum="476B89CD948E9B74" modified="2018-02-28" version="1">MRGPTIIKAEDDKTRQLNKNSLMAFSGEAGDTVQFAEYIQANIQLYTMRNDTELGPNAVANFVRGELARSLRSRSPYTVNLLLAGVDPISEKPNLYWIDYLASLAPVPYAAHGYAQYYCLSTLDKHHHPDITLEQGLKLLEMCTDELKRRLPIDYKGVLVKVISKDGVKEVDFDNDRIVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNP6</accession>
    <name>A0A2I2GNP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bifunctional purine biosynthesis protein ADE16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_432136</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709792.1">
        <property type="nucleotide sequence ID" value="XM_024848195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNP6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNP6"/>
    <dbReference type="GeneID" id="36555894"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432136"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB54490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="595" mass="65140" checksum="5EE71A2FCBB3C1A1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPK3</accession>
    <name>A0A2I2GPK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_374187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710106.1">
        <property type="nucleotide sequence ID" value="XM_024845276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPK3"/>
    <dbReference type="GeneID" id="36552976"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374187"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="566" mass="60943" checksum="ECD9DD9B1554DE7A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPQ1</accession>
    <name>A0A2I2GPQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_432428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710157.1">
        <property type="nucleotide sequence ID" value="XM_024848258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPQ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPQ1"/>
    <dbReference type="GeneID" id="36555957"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432428"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="296" mass="32336" checksum="2854C8273BA2416B" modified="2018-02-28" version="1">MSSLTVNISPETSIHARITRPITPSNKPLLVFLHYWGGSSSTWHKLTSPGSPTTLVTSYPTVALDLRGWGESTGPSDTHAAHYSISALASDVASVLQHIQSNSNTRDLLAHGFLLVGHSMGAKVSLATLSILPAQLLQQLRGLVLVAPAPPTSLELPSEMKDQQKVAYQNEKSIRWTVENVLANAHKLSEQDMDLIIRVSLSGNQLAKEAWPAYGMQEDITENAKRALGLVSYDGFRVRVLVGELDIVEPKERVEDEVVRFFQEIGVGVSLRTVEGVGHLIPLEDPEVVQNEIAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQM6</accession>
    <name>A0A2I2GQM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCAAT-binding factor complex subunit HapC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_470598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710482.1">
        <property type="nucleotide sequence ID" value="XM_024852775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQM6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQM6"/>
    <dbReference type="GeneID" id="36560473"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470598"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000039">
        <property type="entry name" value="Nuclear transcription Y subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="211" mass="22589" checksum="81A902B92D83C11E" modified="2018-02-28" version="1">MSSASPSKEPEVDPEVQSGEEQDQMDKEQQDAQGQGEFEVKEQDRWLPIANVARIMKLALPDNAKIAKEAKECMQECVSEFISFITSEASEKCQQEKRKTVNGEDILFAMTSLGFENYAEALKIYLSKYRETQSARGEHQNRPTSSGYGAGGPVGGVGAAPGGRPGAFGDAADSANSIMNPGLDAAEQETAAYGYPPMVGQPHNGTGGDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQV0</accession>
    <name>A0A2I2GQV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative DNA repair protein Rad1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_346286</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710560.1">
        <property type="nucleotide sequence ID" value="XM_024843556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQV0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQV0"/>
    <dbReference type="GeneID" id="36551256"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346286"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="469" mass="50722" checksum="AFCB76B0D55AFC39" modified="2018-02-28" version="1">MSLNEVWEAASASPYTPFIGKESQFSIGFGLLLSAFILTGLFGLNRSFLSIASFGIPASLAFGFGAVYMICAVGVYFFYCTDLSSRAMAAVEPIFSAVSSNTQHLYTLLQCIGFAPKATVQITPDGIRFSVQDTRVVQGLAFLDKALFTSYTFNQSTVAGNRDETGEDDDESSDTTPYPCFVVSLSALLETLKIFGANDMTTPGTNRAASVAPPNPSASSAFTAPALLLDRSCTFQYFRDGSPLSITLSETGVKTTCELTTYELDGSEVDIPLQREAIIMKIIMRSAWLHNAVTELGATDPRVLRISASAKEEPFFSLSGHGGPFSESSVEFSIEQQDQNTGTPHESHHKVLADDGTSRARATRAKLAPTVTETFLVSPPSSMGSRIKQDYRFPLIQKASRAMAAANKVSIRGDRQGVLSLQFMIEFDLNESGQARSAAKPPVSFVDFRFVPLLDEEAGEDEDGEDTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR09</accession>
    <name>A0A2I2GR09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">P170DRAFT_432811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR09"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR09"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432811"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="241" mass="27142" checksum="BD6F8A158BE5E385" modified="2018-02-28" version="1">MANEIQQTNNDHLIQSTDPEHPANLIPELCRKFYNWGWVTGTGGGTSIRRGEHIFIAPSGVQKELMQSQNIFVLEYPTPKYPPEDRKYIRKPLALKPSACTPLFLAAFERGAGCCIHTHSQWAVLVTLLVERELGPGGYFEISNIEQIKGIPRGKGKGMLGFFDTLRIPIIENTAFEEDLTGALEKAMEENPDTYAVLVRRHGIYVWGDDVAKAKTQCESLDYLFQLAVEMHKLGIPWVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRC9</accession>
    <name>A0A2I2GRC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative checkpoint protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_452810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710723.1">
        <property type="nucleotide sequence ID" value="XM_024851303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRC9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRC9"/>
    <dbReference type="GeneID" id="36559002"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452810"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="824"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1231" mass="138181" checksum="1E0202D6FDF8DCD6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRL5</accession>
    <name>A0A2I2GRL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_399651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710796.1">
        <property type="nucleotide sequence ID" value="XM_024846290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRL5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRL5"/>
    <dbReference type="GeneID" id="36553989"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399651"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="610" mass="68927" checksum="6B2E7937E331285C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRX9</accession>
    <name>A0A2I2GRX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_347038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with ATG1 to form the ATG1-ATG13 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710926.1">
        <property type="nucleotide sequence ID" value="XM_024843604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRX9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRX9"/>
    <dbReference type="GeneID" id="36551304"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347038"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000010">
        <property type="entry name" value="Autophagy-related protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="12">
        <location>
            <begin position="76"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="634"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="778"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="783"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="970" mass="103644" checksum="27D10FCD2F5A8324" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQ32</accession>
    <name>A0A2I2FQ32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_396053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000035">
        <property type="protein sequence ID" value="PLB42738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698040.1">
        <property type="nucleotide sequence ID" value="XM_024846101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQ32"/>
    <dbReference type="GeneID" id="36553800"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396053"/>
    <dbReference type="OrthoDB" id="4378137at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17381" checksum="28A641A398D866D8" modified="2018-02-28" version="1">MIGRADIEGSKSNVAMNAWLPQASYPCGNFSGTSSLKFRGTKGSIGHTFMVCIHTENQNQGDFYPFVLLEISVLHESPLGHLRCGLTDVPPQPNSPPDNVFNPDRPAKDLNARRWAVKPMVFHWRRSSHLFYTPYVFSQCQTRVKLNRVFFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR34</accession>
    <name>A0A2I2FR34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698395.1">
        <property type="nucleotide sequence ID" value="XM_024850339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR34"/>
    <dbReference type="GeneID" id="36558038"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441547"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="142" mass="15576" checksum="BA518573E9E446DD" modified="2018-02-28" version="1">MSILWPILGPITEAPRLPDHQVTFQKDLLGEGRTRGPSTSEFQPNVESQEVEIESTAYEESSGEMDEGTEGSVTDKESSVQNLVEKYQSADSKRLSAHPEFKASATPSRTDFPSTKLMQPRESAEGNDKALQSAGETDDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR63</accession>
    <name>A0A2I2FR63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative MIND kinetochore complex component Nnf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_418830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698425.1">
        <property type="nucleotide sequence ID" value="XM_024847245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR63"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR63"/>
    <dbReference type="GeneID" id="36554944"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418830"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB43123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="226" mass="24691" checksum="8CE511EB93E6D531" modified="2018-02-28" version="1">MAEERGPSHPDPSRSAASPSPPPPVPVPLTPGPRAAVLHKVFDQALARTLRANSYANFSGCFPTPAKYVPGSLESVWRQLNAKLEESARAEFDDIVRERDAVRQLNELDRLVGEALNRRDNGQGDGEVAAHTLSPDELYRAHLTPYLQETQTTLDSQIETTQTENAELAHRVQAQRVEIESLLSGLESVVADLEGAAAAATQFCDENDLRKEAVQMDGEVKARSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRZ0</accession>
    <name>A0A2I2FRZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_481326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698681.1">
        <property type="nucleotide sequence ID" value="XM_024853859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRZ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRZ0"/>
    <dbReference type="GeneID" id="36561557"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_481326"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF12">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190801" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="324" mass="35584" checksum="BBE9380D05ECA1E8" modified="2018-02-28" version="1">MRSFILSSALAAGMAQAYTVTTSDLFMYKNIDPLVVPGEYKSHMHSFFGSDAVTVNTTTSAELQQGCSSTANPNDFSTYWVPTLYLVKDGTRTPVTVNRFSAYYIDLDKAEIPIPQDYTDLAGNAGAQSQDDVDANAGIQWFCEGDEAEDKDEAAFPTQTCSTHLQTLLLFRDCVNPDTLESAYSGNPRVNEGYQDSNWCPQGMSRIPRLRFSIRYDLRSLLPDGWSGEAPFELACGSSYCSHGDFINGWVPEAAQNMVGAESNRNFVAINGPKGNADAGSVCGAENAQDADPDHGTSDYDKSREMMGMTRKRSHKPRFGRTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS07</accession>
    <name>A0A2I2FS07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutathione-independent formaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_394971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698717.1">
        <property type="nucleotide sequence ID" value="XM_024846081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS07"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS07"/>
    <dbReference type="GeneID" id="36553780"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394971"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="384" mass="41020" checksum="225AC76BE3563E9F" modified="2018-02-28" version="1" fragment="single">MASTMKALNYLGPYKVRVEDVDRPKLEHPDDVIVKVTTAAICGSDLHMYEGRTAAEPGITFGHENMGIVEELGEGVTLLKKGDRVVMPFNVADGRCRNCEQGYTAFCTGVNPGFAGGAYGYVAMGPYRGGQAQYIRVPYADFNALLLPPGTEHEADFVLLADIFPTGWHGVEISGFKSGESIAVFGAGPVGLMAAYSATLRGASRVFVVDRVPERLAAAQKIGCIPIDFTTVNTVEEIIRLNGGMVDRSVDAVGYQAVDKSGSSEKPNIVLENMISVTRACGGMGIPGLYVPSDPGASDEASAKGAISLSFGKLFEKGLSLATGQCNVKAYNRYLRDMIVAGKAKPSFVISHEIALDDAEIAYHKFDKREDGYTKVIIHPNGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSQ9</accession>
    <name>A0A2I2FSQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter CDR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_369693</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698948.1">
        <property type="nucleotide sequence ID" value="XM_024844923.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FSQ9"/>
    <dbReference type="GeneID" id="36552623"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369693"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1185"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1220"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1262"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1307"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1336"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1362"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1462"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="152"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="849"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB43646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1494" mass="167346" checksum="041B8E1169DD6015" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSU3</accession>
    <name>A0A2I2FSU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_480636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698978.1">
        <property type="nucleotide sequence ID" value="XM_024853797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSU3"/>
    <dbReference type="GeneID" id="36561495"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480636"/>
    <dbReference type="OrthoDB" id="3443409at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="69" mass="7616" checksum="E75D4F4BD1D929AD" modified="2018-02-28" version="1">MRAKARPFRPGSMPITSAVAPPSLHPEITCREPSVHFIRTSIDGSKDGRCGESPHDRFIVVVGKCRLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT64</accession>
    <name>A0A2I2FT64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_450972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699114.1">
        <property type="nucleotide sequence ID" value="XM_024851160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT64"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT64"/>
    <dbReference type="GeneID" id="36558859"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450972"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF16">
        <property type="entry name" value="PURINE-CYTOSINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="504" mass="55324" checksum="5D1640B71880CDDA" modified="2018-02-28" version="1">MVSDVEKDRVSSLQSVTQDGLEFRDRETSAFTSRYQRWARNIKGLETRGIEPVPLDERLEPNASNSLHMLLMWFSMGMSLNNIVVGSLGTLTLHLSYSDAALCAVFGSLLGGLAVGWMSTWGPRSGNRTLIVARYFMGYHPSKVCCTLNILTNLGYGMMNCMIGGQLLSKLSGGAVSVIVGIIIVALASWIMATFGVRIFQIYERFAWVPQLMVLCIIIGSAGPYFNFDNSSVGSSEKLHGNRLAFFSFCLSVALSWVPLASDYYVNFPPSTRKWKIWSMTTIGLCLSMMTTLLLGAGLGSGVAYRPKWAAIYDGSPGSLLMAGYLRLGAFGKFCAVINVVTVVSNNAPGSYSMAMNFQMLGNMWRKIPRPIFTILTTITYAACAIGGRNSLYEIFKNFLPLIGYWVIIWFAIVVEQDLLFNRGIGYDWSIWNVRQKLPVGMAASAAFLIGWVGAIVGMDQAYYTGPIAQTIEGGCDLGIWLGFGFAALAFPPLRLLELKIIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTC6</accession>
    <name>A0A2I2FTC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_63216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699129.1">
        <property type="nucleotide sequence ID" value="XM_024855308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTC6"/>
    <dbReference type="GeneID" id="36563014"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_63216"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="136"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="276" mass="29714" checksum="287D695381196E88" modified="2018-02-28" version="1">MDQTSSPENKAVSVQVMGLDYRHGISVLEAVVYIPTFIVALLVVFRHGFRKSAGWTTLVMFALVRVVGSFVHLATLAHPLSSDLYLTYAVCFAIGLFQLTVSCIGLLSRVCIHPTANPAPFPNPHGTRLGMSYTDSGKPAHPCLFGLLSLATIAAMILSIIGQVQSADAERPASANSLSQASVVIFLVVWAGLAILVFSMASRNRYIKAEERRLVRAVALSMPFLLVRVLYSFLGSFSHNPDFDLLTGSPAVLLGMAVLEEFVICVVCLEAGVMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTD9</accession>
    <name>A0A2I2FTD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_441317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699173.1">
        <property type="nucleotide sequence ID" value="XM_024850286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTD9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTD9"/>
    <dbReference type="GeneID" id="36557985"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441317"/>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="18071" checksum="D42E5F7B7C90433E" modified="2018-02-28" version="1" fragment="single">MIRHHLEPDLHPGAAPAELPRKAGRPPKSQSTLFQKGLRTRRAVMGDEHVDRALESNSSAFAAPMQEMVTEWAWGNVWNRPGLSRKQRSLMNIGLLMALNRTPELAMHIRGAINNGLSEVEIREAIMHSTVYCGAPAGMEATRTAERVLREMAEKGELERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTJ5</accession>
    <name>A0A2I2FTJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_514221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699223.1">
        <property type="nucleotide sequence ID" value="XM_024855189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTJ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTJ5"/>
    <dbReference type="GeneID" id="36562895"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514221"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="292" mass="32618" checksum="20223F5655020BED" modified="2018-02-28" version="1">MSKFGVLVMGPAGAGKTTFCNAMIQHLQNTRRSCFYVNLDPAAETFSYEPDLDIRELITLEDVMEEMGLGPNGGLIYCFEFLLQNLDFISEALDPLSEEYLIIFDMPGQIELYTHVPLLPSLVQFLSRAGPLNVNMCAAYLLESTFVVDKAKFFAGTLSAMSAMLMLEMPHVNILTKMDQVRDMVSRKELRRFTNVDVQLLQDDNDDSPAAVANPMSKDALMSGGSFNQLNRAVAQLIDDFSMVSFLQLDVQEEDSVAAVLSHIDDAIQYHDAQEPREPQDAQDVNYEDADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTU0</accession>
    <name>A0A2I2FTU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Exo-1,3-beta-glucanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_369106</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699299.1">
        <property type="nucleotide sequence ID" value="XM_024844892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTU0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTU0"/>
    <dbReference type="GeneID" id="36552592"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369106"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014183895" description="glucan 1,3-beta-glucosidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="88"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB43997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="393" mass="43230" checksum="8C5D56687D893C83" modified="2018-02-28" version="1">MHLSLALLGALSCLPSTLALPHLQARNSSGYVDWRTFKAEGVNLGGWLCQESTIDSEFWGKYSGGASDEWGLCKHLGPQCGPVLEHRYATYITETDIDKLAGAGVELIRIPTTYAAWIKLPGSHLYSGNQLEYIKKISDYAIKTYGMHVVIDVHSLPGGVNGLTIGEATGHWGWFHNETALDYSLQIVDAVVDFVQNSSYPQSFSISPINEPADSNQDMSVFGTPAALSDRGASWVLKYMQAVVARVAAVNPRIPIMFQGSFKPVEYWSGNFSADTNLIFDVHTYYFERTNVTSQNLPMHLNSDARAKSGDGKFPVFVGEWSIETGSNNSFALRERNFNAGVAAWRRHGQGSTYWTAKFSGNATVAGQGTQADYWSFESFIDHGYVGQFGSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTV7</accession>
    <name>A0A2I2FTV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, alpha/beta fold family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_369705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699346.1">
        <property type="nucleotide sequence ID" value="XM_024844924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTV7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTV7"/>
    <dbReference type="GeneID" id="36552624"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369705"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="553"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="916" mass="99248" checksum="6FF5AEA6CCCF931A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVP0</accession>
    <name>A0A2I2FVP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_365894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700011.1">
        <property type="nucleotide sequence ID" value="XM_024844733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVP0"/>
    <dbReference type="GeneID" id="36552433"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365894"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="543" mass="58934" checksum="0BC5830469867072" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWU7</accession>
    <name>A0A2I2FWU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_440245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700413.1">
        <property type="nucleotide sequence ID" value="XM_024850034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWU7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWU7"/>
    <dbReference type="GeneID" id="36557733"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440245"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014169798" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="452" mass="48873" checksum="470F0FDAE133C5CF" modified="2018-02-28" version="1">MILQPSSALLLVASLLAALPANADGLYTKKSPVLQVNNKNYDQLIANSNYTSILEFYAPWCGHCQNLKPAYEKAAKNLDGLAKVAAINCDEDDNKPLCGRMGVQGFPTLKVVVPGKKPGKPRVEDYQGARSAKAIVNAVVEKIPNHVKKVTDKDLESWLSKDKEAPKAILFTEKGTTSPLIRSVAIEFLGSVDVAQVRNNQAEAVEKFGIENFPAVVLVPGSEKNPIVYDGELKKGPLVEFLSQVATPNPDPAPKAGKSSKSSKSKTQAEKTKPTEASEPEAVPDEAQESQPAKASPQAPAIDELATVDALESACLLPKSGTCVLALLPEFDAELPESTKKALTSLSEIAHRHVQRKSKLFPFYSVPASNEGAKSLRTGLELSQDGKSVEVIVINGRRGWWRQYDPSESADYELARVEAWIDAIKLGEGSKSKLPEGIVKSEDEKAEEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX50</accession>
    <name>A0A2I2FX50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_275524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700521.1">
        <property type="nucleotide sequence ID" value="XM_024843167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX50"/>
    <dbReference type="GeneID" id="36550866"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_275524"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="75" mass="8696" checksum="DE0A52D0F6F5C018" modified="2018-02-28" version="1">MTVCTRSRKKISTGEEICAGGYGQRVFSAIQIGLPRYRSTVQHNHVTLKLWSRRWAATIFIVWWWGVKMRDPCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXR4</accession>
    <name>A0A2I2FXR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_439142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700678.1">
        <property type="nucleotide sequence ID" value="XM_024849769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXR4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXR4"/>
    <dbReference type="GeneID" id="36557468"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439142"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="222"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB45376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="309" mass="33143" checksum="280A4B71E0C9E567" modified="2018-02-28" version="1">MSPAIAQAGAGSASKDVKKESATARLLGSGTAGIAELLVFHPVDTTAKRLMSNQSRITNVSGFKEVVFKEYATAPFGRKFTSLFPGLGYAAGYKVLQRIYKYGGQPFARDYLAKHHGADFDNAFGKGSGKAIMHATAGSLIGIGEIVLLPLDVLKIKRQTNPEAFRGRGLFKIISDEGMGLYRGAGWTAARNAPGSFALFGGSAFAKEYIYSLNDYNSATWGQNFVASVCGASASLVVSAPLDVIKTRIQNRNFENPESGFRIVSKMLKNEGPTSFFKGLTPKLLMTGPKLVFSFWLAQTLIPAFGQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXR7</accession>
    <name>A0A2I2FXR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein uS4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_439192</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700733.1">
        <property type="nucleotide sequence ID" value="XM_024849783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXR7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXR7"/>
    <dbReference type="GeneID" id="36557482"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439192"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000025">
        <property type="entry name" value="30S ribosomal subunit S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB45431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="465" mass="52413" checksum="713D29803272F726" modified="2018-02-28" version="1">MRNRATTPLKPVNKPRIRQSWSKYNLFNINRMQNPNTFYRTFFQQKWMAKSLARSYHGEQLPEKQWQRMFSPRIRSVVPMDPYRLAADDGSAMSAGRGSGLTGPRGSNPRPIPFSQMTFAPLERRLDVAVHRALFASSTRQARQFVVHGAVTVNGKKMRYPGYLLNPGDLFQVDPERVMYATGAPKDKHERRESRVARRKAAETPAEGEGAEEGAAAEESSEKKETETEVDNKKAEEEDPRETLKALLAQAKVIMGSNKEVLPAKRKQELRGFQKAIKRVLSRSDSSTILADSLEAQFSQLTLLLKAKRAEAKQSKKSEQPKESAQEQSPEKPAAAPEAASTEATANENKLGEALTEAFRQAAENPDADVDTSELSDEEFNVLKRALVQMRDNPIDSTKPYATPWRPRDYMSAFAFIPRYLEVNHNICAAVYLRHPVARPGISEVPSPFSESVGTLAYTWYLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXS3</accession>
    <name>A0A2I2FXS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_428688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700730.1">
        <property type="nucleotide sequence ID" value="XM_024847855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXS3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXS3"/>
    <dbReference type="GeneID" id="36555554"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428688"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000101">
        <property type="entry name" value="Cyclin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="399" mass="45107" checksum="37CFF0E380133C29" modified="2018-02-28" version="1">MSSDRKDVASVSGSEAALPDPPPIHPSFIQVAKPYMKEQTIQRCITTMGVDPLREESLRLQGVTWIDNVRRVLCLPIRTFNTAVVYYHRFRLVRPDEYPYMVAMTLFLPSVSQREPDQITQDAAAAALFTACKIEDTLKKSREIVCAAYNLKLAPSEHVSSDNPVFETHARGIIGLERLMLEASGFDFRTRHPQKTLIKLARKYGLDQQSEASKVAYRIAQDLYRTFAPIKQTTSTMAFACLELAGRLLDQRIEAVDQGLDYKAWRTSREEVMEMYTHNRGSTSVGPRFPSDRFLKVRIPLNQEAEAQSLPRFTNWVNERDTKPPNGLKINSGNKQPGATENGDARIHPLIPVAANGERPKAGEKVAVRFMIDPECADGEKSHVAKYFKVEMEEYEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYA2</accession>
    <name>A0A2I2FYA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_512269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700911.1">
        <property type="nucleotide sequence ID" value="XM_024854973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYA2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYA2"/>
    <dbReference type="GeneID" id="36562679"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512269"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="84325" checksum="7DB00922A3403DB1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYJ8</accession>
    <name>A0A2I2FYJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_365550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701015.1">
        <property type="nucleotide sequence ID" value="XM_024844711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYJ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYJ8"/>
    <dbReference type="GeneID" id="36552411"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365550"/>
    <dbReference type="OrthoDB" id="2125396at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="383" mass="41922" checksum="C7144B99CB4B54C6" modified="2018-02-28" version="1">MHASPPIYLPTEIILQIVGFIAADESCRQEALHSCCLVSRQWYSAAIAPLYEKPHVGTGVAFGRFTDTISPPIGARKSKLNLGSLVHRLDLSGLVHHSSNSLTARLLGRVKENLEIFIAPKVSFSINSLPALSKCVNLRSLDLSLVGDPIPFTNLKQALSRLRKLSTLRLPRSTILTPPESSSASQAIEWPPQLTRLQLSGRFNPLTIPTFAWPLSLTSLSLKNCSDLSVSNLGSLMSSPYLNHSLQRLSISGANRGLQPESVNAILAFLPRLTTLSIPGDMVEDTFFEILCHMAPAVALEVLEFSYPSLDPNLVFSTEALIRALGSGLANLRAVGFADLFCTEQRVEEDEDVEEILQKRAAERSGEGGYEEREDLLVGVYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYM8</accession>
    <name>A0A2I2FYM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_478672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701036.1">
        <property type="nucleotide sequence ID" value="XM_024853583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYM8"/>
    <dbReference type="GeneID" id="36561281"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478672"/>
    <dbReference type="OrthoDB" id="4499133at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="195" mass="21450" checksum="D5703EC424CBBD89" modified="2018-02-28" version="1">MSLGPEASQIPVIVRRGLPRLNPRIPPIAKASGPGKLAAISHGKLQRESMSHSPDLRRCLGHHDVYRKSVKAAQENARQSIDAMSGEEEAVSGDTPTRNESKDENTMPHFRAQITNAVKAMVRRRYHTSTSETLQPKLPEAKLQEAKLQAIPVVAQGSPRVVTVTKRTRRNTPWFLPGRKTFSQSSQLIPPNAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYY2</accession>
    <name>A0A2I2FYY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_364730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701141.1">
        <property type="nucleotide sequence ID" value="XM_024844659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYY2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYY2"/>
    <dbReference type="GeneID" id="36552359"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364730"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014119877" evidence="2">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="235" mass="25818" checksum="795409BD432324CD" modified="2018-02-28" version="1">MQFKTLLPTLAILASTASAWNRIDKDNAALLVIDHQVGLAQLVRDYSTNDFRNNMLAHSALGPLFDLPTVLTTSSDQGPNGLMLKEIVDMHPNATLVQRQGEVNAWDNKAFREAVKATGKKQLIIGGIVTEVCTAFLALSLVDEGYEVFANTEASGTFDVKLAEDANRRMERAGVTLMGLFGIVTDLMRDWRAKPGLDEVLPYLDKYQFAYGLAARHHAGALRNGTLFPVEELLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZJ0</accession>
    <name>A0A2I2FZJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_365562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701355.1">
        <property type="nucleotide sequence ID" value="XM_024844713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZJ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZJ0"/>
    <dbReference type="GeneID" id="36552413"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365562"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22699">
        <property type="entry name" value="FHA_PLM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="109"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="516" mass="57146" checksum="25477D4287C81163" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G004</accession>
    <name>A0A2I2G004_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_467324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701519.1">
        <property type="nucleotide sequence ID" value="XM_024852475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G004"/>
    <dbReference type="GeneID" id="36560173"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467324"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="34"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="550" mass="58760" checksum="C4A6298204900FE0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G042</accession>
    <name>A0A2I2G042_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_458347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701560.1">
        <property type="nucleotide sequence ID" value="XM_024851790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G042"/>
    <dbReference type="STRING" id="1392250.A0A2I2G042"/>
    <dbReference type="GeneID" id="36559489"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458347"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7708" evidence="4">
        <location>
            <begin position="89"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="286"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="5">
        <location>
            <begin position="507"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="739"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="967" mass="108486" checksum="07053F6EE22921CB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G080</accession>
    <name>A0A2I2G080_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_415249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701593.1">
        <property type="nucleotide sequence ID" value="XM_024847054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G080"/>
    <dbReference type="STRING" id="1392250.A0A2I2G080"/>
    <dbReference type="GeneID" id="36554753"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415249"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023:SF6">
        <property type="entry name" value="LIPASE CLASS 3 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023">
        <property type="entry name" value="LIPASE CLASS 3 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="284"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="533" mass="58500" checksum="1F978201F317E34C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0G1</accession>
    <name>A0A2I2G0G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_387234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701680.1">
        <property type="nucleotide sequence ID" value="XM_024845795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0G1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0G1"/>
    <dbReference type="GeneID" id="36553494"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_387234"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="316"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="374" mass="40634" checksum="CB5BEA6D0C4698BC" modified="2018-02-28" version="1">MATNLKAEMMLCIDDIKSAATAKLPFIVREFYSSGSTQQVTVSENSSAYNKYRLRPRVLVDVSGLDISTTVFGQRIAFPLGLSPTGIQAMAHPDGELATSRACARRNVPMGVSSFANHSVEEITQAGQAIGPAIHVMQVYTMRDRAKQERIIRRAEAAGCKAIFLTADSPVLGVRYTEVKHDFRTPAGLSFPMIEWDSETIQNQTHDAGFVAFNSDAHSWAKEIPWLRSITKMQIWIKGVLTAEDVLLAKQFGCDGVVVSNHGGRQLDGTPATLDALPECVKAAGGQIRVHIDGGIRTGSDIFKALALGAECCWIGRPTLWGLAYDGEKGVSRVLDILYDEFKRCMQLTGCRTLADVSTASIGVLRSDGPLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G131</accession>
    <name>A0A2I2G131_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_498535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701892.1">
        <property type="nucleotide sequence ID" value="XM_024854136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G131"/>
    <dbReference type="STRING" id="1392250.A0A2I2G131"/>
    <dbReference type="GeneID" id="36561841"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_498535"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="144"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="353" mass="38649" checksum="62FC14235B74D1DA" modified="2018-02-28" version="1">MTLPTLRWGIIGTGLISSWFVSDLVETREDAQATHLIQAIGSSSDTKAQAFIKEHSPNSNPSLYSSYDGVYADPNVDIVYIGLPHVFHKEACLQAISHGKHVLCEKPFTVNAREAKEVFEAARQKGVFVMEALWTRFMPLVRQLTQIIHVDKAIGNVHRVFCDFGLDIDLDNLPDSSRLKDPALGAGSLLDIGIYSLTWGLLLLEDHPPDDAAQPQVFSAQTLHAGADIATSIILSYPDSGRQGILTSTMQTKTNPVFARVEGSRGSITIEGVAASLPGKFTVFSKDAKMEPVVYEAPKSPGKGFFYEADAVALDIAAKRVENEIMPWKETVRVLEIMDGIRERGGGHFPQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G134</accession>
    <name>A0A2I2G134_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701906.1">
        <property type="nucleotide sequence ID" value="XM_024849578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G134"/>
    <dbReference type="STRING" id="1392250.A0A2I2G134"/>
    <dbReference type="GeneID" id="36557277"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438323"/>
    <dbReference type="OrthoDB" id="5308323at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014154592" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21613" checksum="40A0A1202DA89C8B" modified="2018-02-28" version="1">MQNFLPTLLLLITTVTATPTPIDLVRRECKYLAPSAIDILSESNPDTPSLGNHFSLSHEANPSRNTETVALTFTDIPATASGCVLQLAIPKLTHENEIASGTATQAEIWKTNPWTHDDAPTWSHPPHKDRMVSTTGFPTEVTDEKDVRWLASDTCSETMSYYVELSDWQNSEGDVDFENHVDGGDGDLGFRMVYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1Q2</accession>
    <name>A0A2I2G1Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_223392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702101.1">
        <property type="nucleotide sequence ID" value="XM_024842873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1Q2"/>
    <dbReference type="GeneID" id="36550572"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_223392"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="182" mass="20838" checksum="E16C72118274E559" modified="2018-02-28" version="1">MKFCFHDNNILFFPIPCLYKLSNQLQSTSDFLEFKPNTTFFFFFSFSPSFFPVLPSLLPFRANPRPAPLLLLLFLPTTSFSLPPSVLLSHTPSPLLSASSPPLSSLLPPPSSRLIRHSFINIPFGRRLDSFARARPLYNSDLNTPLSFLLHSALELWYSRLFICPSIRKRLFFFFFFSSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G256</accession>
    <name>A0A2I2G256_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED18</name>
        <name evidence="10" type="ORF">P170DRAFT_362750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G256"/>
    <dbReference type="STRING" id="1392250.A0A2I2G256"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362750"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="270" mass="30066" checksum="9AE0EE15EACFD51A" modified="2018-02-28" version="1">MHELLLFASVPAHQHHELLQQLAGLTAMQPRHRLERRLIFKAHRKPGLINTHVGASQDVQGPDMQRLNKMLNGGMFYTQVVGPVSPADLGASPPPTSLGDTDASMAGTDEKGGHVYCYDHQPWKLEFRDIPEAGTRSAVTTRLTASAGLPKGDISTPMNAWGYSYVTEYMVEGDVFILNDIVIFLHRVLQYPTEGQEPHEPRRQLPPFQQMTSLDRTGSYVLQASITVQDGGNQEMMKTASQHLFGLREQLKSAVRLEQADRLSLDTRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2F2</accession>
    <name>A0A2I2G2F2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FabD/lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_448736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702353.1">
        <property type="nucleotide sequence ID" value="XM_024850989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2F2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2F2"/>
    <dbReference type="GeneID" id="36558688"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448736"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="606" mass="67147" checksum="38F9C518AFEECD58" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G303</accession>
    <name>A0A2I2G303_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_237283</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702558.1">
        <property type="nucleotide sequence ID" value="XM_024842934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G303"/>
    <dbReference type="STRING" id="1392250.A0A2I2G303"/>
    <dbReference type="GeneID" id="36550633"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_237283"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000084">
        <property type="entry name" value="Transcription factor TFIIH subunit Tfb4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB47256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="371" mass="39657" checksum="817421270C82141C" modified="2018-02-28" version="1">MNSVDATEHYETSAHDPAPSLLTVIFDTNPHAWALLENELPLSKAIANVLVFLNAHLACNYANEVAVVASHSQQATWLYPREENQNPSAVDKNGTTGVPQSQVNKYRPFRIVEEQVTRNLHALMAETSVSDVKSTSATMMAGALTLALSHINRRSIAWSEAHGGDTSTADGGSGAPGTGPGTGPGGTSASEGGLQSRILIVSVSGSSDSAHQYIPIMNGIFACQRLHIPIDVCKLRGDAVFLQQASDATRGAYMALTEPRGLLQYLMMAFLPDQRSRRHLVLPTRVDVDFRAACFCHRRVVDIGFVCSICLSIFCEPPENGNCLTCGTHLEMGDYGAKPALIARKKAKKKKPRANGPSGTATPTPTPTPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3H9</accession>
    <name>A0A2I2G3H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_413366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702731.1">
        <property type="nucleotide sequence ID" value="XM_024846974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3H9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3H9"/>
    <dbReference type="GeneID" id="36554673"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413366"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="497" mass="55187" checksum="459E8DEE49C9E7AD" modified="2018-02-28" version="1">MAPIFEQDNKQTTSFSPRSNEGDMASKSPSDPNLVTWNGPDDPDNPLNWSRANKWTATILVSCFTFISPVSSTMVAPALSTMATEFHIGSGIEQNLLMSIFLLAYALGPFIIAPLSEMYGRVVVLQSANMFYLVFNTVCGFATSREQMLAFRFLSGFGGSAPQAIGGGVLSDCWHKEERGAATALYSVMPFLGPAIGPIAGGYLTQYLSWRWIFWIVSMADATIQVLAFLLLSETYAPRILAIRKERLQRRTGNRNLHTEYDSPDRSFGQVLRKNLVRPFIMLFTQPAIQALALYRGYQYGLMYLVLASFPMVWEETYEESKGTASLNYLSLGVGFIIGLQFCGRVLDRVYLRLKKHYNHDGRPEFRIPLMLPGGLLVPIGLFIYGWTAESRTHWIVPNIGGAIFAIGLIISFQCAQTYVVDAYSRYAASATGVAAFVRTLAGFAFPLFADSLYRRLGLGWGNSLLGFVSLGLGIVSPILLWFYGEWLREKSPYCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3T7</accession>
    <name>A0A2I2G3T7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TATA-binding protein-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_409690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702846.1">
        <property type="nucleotide sequence ID" value="XM_024846800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3T7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3T7"/>
    <dbReference type="GeneID" id="36554499"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409690"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="855"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1036" mass="112978" checksum="83EF1BB29F461551" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5U4</accession>
    <name>A0A2I2G5U4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_359380</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703541.1">
        <property type="nucleotide sequence ID" value="XM_024844351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5U4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5U4"/>
    <dbReference type="GeneID" id="36552051"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359380"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014199222" description="Autophagy-related protein 27" evidence="19">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="20">
        <location>
            <begin position="23"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB48239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="307" mass="34009" checksum="74BC592FB8E13475" modified="2018-02-28" version="1">MRVSSALSSAALLFSGLASARGFDCKDIVVDKYKYNLNPLGGVHVLYDNNVTESSSVNTTYVLNICGILKGASNRDGMKCGTSKNICGFEKTHFPDGAETKKPFPIAGLEPGGHGSMEPQITRLKSDDSDREGLRVKLSGGSYENADGKKKKAGAVIEFQCDPDRSGLEGLESTKDEEMRRREEAGDAQDQQSLQFKSFGLADDDSYVLRLDWKTRYACDNYVDDKEGDSSSHWGFFTWLIIILFLVIAAYLIFGSWLNYNRYGARGWDLLPHGDTLRDVPYIFQDWLRRVINTLQGSGSRGGYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5Y5</accession>
    <name>A0A2I2G5Y5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein Dds20/Sfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_359785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703589.1">
        <property type="nucleotide sequence ID" value="XM_024844378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5Y5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5Y5"/>
    <dbReference type="GeneID" id="36552078"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359785"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527">
        <property type="entry name" value="MATING-TYPE SWITCHING PROTEIN SWI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527:SF1">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32831" checksum="D54FCF6132763512" modified="2018-02-28" version="1">MGPGTLNEKRRRAQHATSALSKPFKSPLRRPLQTSEIKEETSPTIKERISSPDPTHQASAAHPAGEAKTEPEPTTSTTLSSSAPSINSPSSSASSPLSSRNRKRKNPTSRLTPSKKPVLLDPETTALQKQQRALQSRLSALRSELDTARQALRVESSGKDTELEKLIGKWKGVSRNAAEEVFAGAQERVTRLGGMKAWREQMRNNNSRWEQEEMDSWYGGAEGDGVDVDEEELEARKAEMLEQWDVPGKEAEDKKREEATEEEEFTMDFMLKTLNVDLKLIGYDKEGQRWVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G606</accession>
    <name>A0A2I2G606_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_465707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703609.1">
        <property type="nucleotide sequence ID" value="XM_024852343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G606"/>
    <dbReference type="STRING" id="1392250.A0A2I2G606"/>
    <dbReference type="GeneID" id="36560041"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465707"/>
    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="139" mass="14886" checksum="F6763DE85F34A423" modified="2018-02-28" version="1">MCGPSRPSSGNRIAIMFPSSSEGAIPLAPYSLFFKDIESGTSAVFRIKDSSMLDLFRGSKGVDLRIEKHGDLTSQSSTMPPLHQFFVSPDLEVDQTGTDFEVQLPERLDLDVSDVGIVGRKVSVSVGGQGMGMGIVGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G670</accession>
    <name>A0A2I2G670_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_476988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703672.1">
        <property type="nucleotide sequence ID" value="XM_024853404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G670"/>
    <dbReference type="GeneID" id="36561102"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476988"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="298" mass="34247" checksum="FC7ABCDAC4827BC5" modified="2018-02-28" version="1">MVFGAPIFNRIAPNVAFYLDRANVPNLLFGWLAIGLADTGKDSSEVDFVIPDAQMPAAIASLVAADYPLCTDTKCGELESDRLTGYARQKEFPFTWKHHYHPKPSAHFHMGGTNILSLHVQSALLWWLPELRIGPPAVDDPDLMLWRLRNNTDSLLPSYSEDPLYVQPAIWEDLPQYSEIHSGQSERDNHPIKILNQNSLVEACIMLYCRDWARNEHLKVLWGHMLTELSDRAPCRTKKNVRARFKRAWDSLNFRIVTRRGFFEEMRALRDRLARDNELGPLVNGETWCPPRHDWTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G692</accession>
    <name>A0A2I2G692_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_477012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703699.1">
        <property type="nucleotide sequence ID" value="XM_024853405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G692"/>
    <dbReference type="STRING" id="1392250.A0A2I2G692"/>
    <dbReference type="GeneID" id="36561103"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477012"/>
    <dbReference type="OrthoDB" id="4501863at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="80" mass="9043" checksum="2782904C5CD9F765" modified="2018-02-28" version="1">MSGQSKIELLLQAEVDENDQSFFRLLVDGRSIKYITVEPGIYSFEDMCFEPSLVSVLPELPPGDWNDSLVAKDDNNEYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7K8</accession>
    <name>A0A2I2G7K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_357999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704168.1">
        <property type="nucleotide sequence ID" value="XM_024844255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7K8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7K8"/>
    <dbReference type="GeneID" id="36551955"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357999"/>
    <dbReference type="OrthoDB" id="5339076at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="851" mass="93966" checksum="996C8F215CFB6122" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7W0</accession>
    <name>A0A2I2G7W0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="15">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_407744</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acetylxylan esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Deacetylation of xylans and xylo-oligosaccharides.</text>
            <dbReference type="EC" id="3.1.1.72"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate esterase 1 (CE1) family. AxeA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="15"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704235.1">
        <property type="nucleotide sequence ID" value="XM_024846696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7W0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7W0"/>
    <dbReference type="GeneID" id="36554395"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407744"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029032826" description="Carboxylic ester hydrolase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB48933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="305" mass="33140" checksum="25D9350766D81FF3" modified="2018-02-28" version="1">MTPIRILLSIFLYALCCSARALGHEKLKPRAGSLEQVTDFGDNPTNVGMYIYVPNNLASNPAIIVAIHYCTGTAQAYYTGSPYATYAEQHGFIVIYPESPYEGKCWDVSSQSTLTRDGGGNSNSIANMVTWTIDKYGADKSKVFVTGLSSGAMMTNVMAATYPDLFSAGIVYAGVPAGCFLSTADEKNAWNSTCSQGESITTPAHWAAIAEAMYPGYDGARPKMQIYHGSEDATLYPQNYYETCKQWAGVFGYDYDSPQETKPDTPVANYETTVWGEKVHGVLAGGVDHGIQIQGEEDLKWFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G808</accession>
    <name>A0A2I2G808_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_356574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704318.1">
        <property type="nucleotide sequence ID" value="XM_024844160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G808"/>
    <dbReference type="STRING" id="1392250.A0A2I2G808"/>
    <dbReference type="GeneID" id="36551860"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356574"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="532" mass="58519" checksum="98654846FD7745DE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8K8</accession>
    <name>A0A2I2G8K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chitin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_408296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704524.1">
        <property type="nucleotide sequence ID" value="XM_024846722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8K8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8K8"/>
    <dbReference type="GeneID" id="36554421"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408296"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000088">
        <property type="entry name" value="Chitin biosynthesis protein (Chs5), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="442" mass="47507" checksum="90FD0B46DC983230" modified="2018-02-28" version="1">MLVSLTVGKVDAGVAVLLTQDNRLIEFPSVLLPNNITSGSIVDITVARNHNAEAASAAGFQSLQKRILNTYGVKTPSPPILRLRNATQTSLVLEWEPIDLATASLKSLSLYRNGSKAGSIPRPLETRSTKISGLAVHAEYTFHLVLRTTAGTYQSEKLTCRTHKMTDLSGITVTSGVLPPPQKDALAAALDRIGGKLIDTVRIDTTHFVCTEGRGPLWEKAVEMNIPVVVPEWVDACEAEGTIVSVRGYYLNADPKARQLGPIHGSTQHQRTTSSATSIQQPQTPTHRPQSQSRLSLAPRASRERESHTVGEPPITPFPGANMSGQPTAAEDEIDSDDDQSPPPAPPPKDEAEESEEPSSNGPPAQIVITEPTSPSKDQPSKNEEDHDTEKDQDQESDKGKETAAADAGNDKDAQEEEDSSSNEQTKGKGKEGEGDFNEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8N0</accession>
    <name>A0A2I2G8N0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_329031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704539.1">
        <property type="nucleotide sequence ID" value="XM_024843357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8N0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8N0"/>
    <dbReference type="GeneID" id="36551057"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_329031"/>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="167" mass="18294" checksum="080007790F07C913" modified="2018-02-28" version="1" fragment="single">MSVSASIPDTSLGLTSSEIQILRQQQQIALQGGHAGNGISRGRGTGRTSNSSSRAASAASSHGRLLLDPMSLRALSHQLDALQEQIRSRIDYLEEQMQLSLQNSYDRAGNVICNADAEIARTRSILASIDELENEMAKIGHIREIVKAYRGRIEGLDQRLDQAARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8P5</accession>
    <name>A0A2I2G8P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_408345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704556.1">
        <property type="nucleotide sequence ID" value="XM_024846726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8P5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8P5"/>
    <dbReference type="GeneID" id="36554425"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408345"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="78"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="556" mass="61105" checksum="FC4ED4E319B866F3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8T8</accession>
    <name>A0A2I2G8T8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_357035</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704597.1">
        <property type="nucleotide sequence ID" value="XM_024844192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8T8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8T8"/>
    <dbReference type="GeneID" id="36551892"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357035"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000027">
        <property type="entry name" value="Probable exopolygalacturonase X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF14">
        <property type="entry name" value="EXOPOLYGALACTURONASE X-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014199247" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB49295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="440" mass="47993" checksum="2C7B40AC08BE6390" modified="2018-02-28" version="1">MKLQSLAQTASLLLSLGTAVQGFSRSRNDACKPNNPFKPLPTSSPRTKTCRVKAHGDGTDDSPAILSAIKKCNNGGKVVFDEDKEYTIGTALDLTFLKNIDLEILGKIQFTSDTDYWQEHSFKHTFQNATTFFQIGGEDVNVYGGGTLDGNGQVWYDLFAEDALILRPILVGIIGLKGGTIGPLKLRYSPQWYQLVANSSDVLFDGIDISGYSSSKHEAKNTDGWDTYRSDNIVIQNSVINNGDDCVSFKPNSTDILVQNLHCNGSHGISVGSLGQYKGEVDIVKNVLVYNISMYNASDMARIKVWPGIDSAMSEDLQGGGGLGAVSNITYNKMYIENVDWAIEVTQCYGQKNLTLCNEHPSNLTISDIHFNDFKGTTSGKRDPYVGTIVCSSPDVCSDIYTSNINVKSPKGTDDFVCTNVDTELLDVQCEKPKSDTLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8W2</accession>
    <name>A0A2I2G8W2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_356989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704622.1">
        <property type="nucleotide sequence ID" value="XM_024844189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8W2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8W2"/>
    <dbReference type="GeneID" id="36551889"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356989"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="344" mass="36635" checksum="68E51F9C52ECE497" modified="2018-02-28" version="1">MTTHTVFRLPSLGAITNLTRQTEPLPTISKHEVLIRIRSVALNSRDLQVATNTYPAATKNELIPCSDGAGDIVSVGSEVKDLKEGDRVVISFDPMHQYGPQKDFLSCQGGAADGTLAQYVARPATGVVKVPEGAPHSYAELASLVCTGVTAWNGLYGNVPLKPGQVVLLQGTGGVAVTGLILAKAAGATTIMTSSSDEKLAQIKSKFQPDYTINYKKTPDWAAEAIKITGGKGVDHILEIGGLGTIEQSIKAITPGGVISVIGYLAGSDKVVDVPLQALLKTCVVRGVLIGPKCMLEDLVTFVYRKELRMPVEKEFGFSRDEVIAAYEYLRSGQHVGKVCIRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8Z8</accession>
    <name>A0A2I2G8Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_509909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704653.1">
        <property type="nucleotide sequence ID" value="XM_024854724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8Z8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8Z8"/>
    <dbReference type="GeneID" id="36562430"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509909"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56852" checksum="32909A61C0FC2030" modified="2018-02-28" version="1">MPRTRRLLRDEQITYSVAQEQETNILHQLGYPEQQSRFFAHLHARQDWMKAIVAHHLGLHTSAVCHVADEAHWLSGSFNVFVPVTIDGWNGTRVLIRFPLPYRVGESVRPGNGDEKIRCEAGTYAWLQENCSDIPIPCLYGFALSTGETFTRLESLPIPTRSYQVLRRRILTWLGYPVSKYVRHQIANHTTLDGVVGSGYLLVEYIEETQGQMLSGTWVNGQHNAKLRRNLFRANRPLSMEVHQLENENIPTYIPRDYTYSTVDSYITDMLSLHDSRFRHQPNAINDLGDCGYQLSALSTMRTIFSSLFRRDFRRGPFSLTLTDLHQSNIFVDAEWNITCLVDLEWACSMPMEMISPPHWLTNKAVDQLDAAEYDAVRMEFMKALVAEEKERELKSTALGMVGNSEAVPRLSDVMSQAWATGTFWYTLALSSPSGLFSIFHKHVRPLFCANYGEEFNLIMPFFWERNIGYIAARKLSDKREYDERLRQTFEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G902</accession>
    <name>A0A2I2G902_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_182744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704668.1">
        <property type="nucleotide sequence ID" value="XM_024842667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G902"/>
    <dbReference type="STRING" id="1392250.A0A2I2G902"/>
    <dbReference type="GeneID" id="36550365"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_182744"/>
    <dbReference type="OrthoDB" id="5273847at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="256"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="647" mass="73329" checksum="67661886F156BDAD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9B2</accession>
    <name>A0A2I2G9B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_184777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704774.1">
        <property type="nucleotide sequence ID" value="XM_024842687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9B2"/>
    <dbReference type="GeneID" id="36550385"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_184777"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="120" mass="13987" checksum="92EEEF9FAF4B33C2" modified="2018-02-28" version="1">MTYLYEWHEQYLLSLEGLLFMFLLCFSFTYTICGRKLRLASSVLLNKVLGVSGSGFPVFSNITSPRIMSIFAFRVVLFCSSLRTLFSADSMFFDSFRFSTLYCCLFFYIEDTIYLIAFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9E5</accession>
    <name>A0A2I2G9E5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Putative bifunctional purine Ade1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_408812</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704790.1">
        <property type="nucleotide sequence ID" value="XM_024846746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9E5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9E5"/>
    <dbReference type="GeneID" id="36554445"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408812"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="116"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="816" mass="85734" checksum="3B25A43AFED42206" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9X0</accession>
    <name>A0A2I2G9X0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_384859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704967.1">
        <property type="nucleotide sequence ID" value="XM_024845694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9X0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9X0"/>
    <dbReference type="GeneID" id="36553393"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384859"/>
    <dbReference type="OrthoDB" id="5068804at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="246"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="424" mass="47126" checksum="97A106D8BE1C3A1E" modified="2018-02-28" version="1">MAEAFGIASGLVGLAGFAFQTSKSLYQLVESFKSSKRAIRDLRDELQSLNDVLKTLKGTAAELEDELDALKQPLLRCGRICQEFEEILKRCTSHSGVDRTSFRDWAKLRYMGGDINNLRTTLAGYKATISIALGSATFRHAAVTSNVLDEFKRMIDEATSDLQDHLHEIYENLQLLNEASEGPLSSNLDSRVIEEEKQSTEQCLDICARASEYIESLQAGMLHDSVSTRDLPAESAHKENVEPQHARKVTAAMFHDFQLKLNANSNSLESRLAELRSRLAEAQKRQKISKDEATRLEMMQEEKDSVEQCLNICADASDLAGSARINSFEDVNSADDSRQLIVSTIGDLISAKRIVTGNRSEQWLGQMSDDTIRHLSQTPRTVVGNLGESKEGASQEKNTEFHNRWGAGYPLKTKSEEGHASFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Z7</accession>
    <name>A0A2I2G9Z7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terrelysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705011.1">
        <property type="nucleotide sequence ID" value="XM_024849319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Z7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Z7"/>
    <dbReference type="GeneID" id="36557018"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437249"/>
    <dbReference type="OrthoDB" id="2727348at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:symbiont-mediated hemolysis of host erythrocyte"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18992" checksum="24FE264BA7F33A1B" modified="2018-02-28" version="1">MSNMSTIDAAEVLNKYNSQWVEFHIRDHLEKGEISIRHTVIEGGEFHNPDTTKPMTEDDVDELTIPSYGVGEICARGRRGSEGRLDLFHDDEKICELHWDNRQENGLNLVEVLDGSKQYRVEHGGWSPEAGPLGHVYVDIWEMKKKLEEKKMLEQKIEEMQKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA00</accession>
    <name>A0A2I2GA00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_437242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704997.1">
        <property type="nucleotide sequence ID" value="XM_024849317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA00"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA00"/>
    <dbReference type="GeneID" id="36557016"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437242"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="8"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="356" mass="37961" checksum="586F69FD64D28AF3" modified="2018-02-28" version="1">MQKALIVTELDAPVTLTTNWPIPEPNQNQVQVKVTVAGLNPHDQKSRDWGLFILRDLTPESSRASDLPSVLTSDVVGKVTKLGPGVTDLAIGDRIVYQSSFAPGSTQNGLQEYAVADIRALAKIPDSITDDEAATLPTNIITSFVALFDTLQILTPWSAASKQFGSANTAILIIGGGSNCGQFGVQLAKLAGIGRIVVVGGDRDKLISFGATHVIDRHAGYESILAEIRDIVGDDLLYAYDAINPLEGQLLALNALSGSKKGALARLIPRGKVDESRVLGKMAGFDVRDLFGSSHAHPEFAAELWSRVSGFLESGQIKPLDYVVKKGLDAGVVNGVLDAYKDGERVARTHVHVSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA05</accession>
    <name>A0A2I2GA05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_409295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705012.1">
        <property type="nucleotide sequence ID" value="XM_024846769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA05"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA05"/>
    <dbReference type="GeneID" id="36554468"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409295"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="305" mass="33715" checksum="33CF9B89E08D1DA1" modified="2018-02-28" version="1">MRPTTREEFEVAIICALPHEADAVKASFDETYDTHSHYYSKRPGDINVYTNGRIEQHNVVLCHLPNMGKGSAAVVASNLRMSYPGVQLALVVGICGAVPVSKDGVKIALGDVIISDSLVEYDIGRQYPDGFQRKNDAKSMFGRPSLEIRTVLASLRTLDIGEQFQERIHYHFKALQARKPVWENPSTSLHHESLHEKEKDSQILQSGLHEDTPGPALHIGTMASADTVMKSDTHRDELAHSEGIIGFEMEGPGVWDIFPCLIIKGVCDYADSQKNKLFQNYAAATGAAGAKAFLSHWRSNIRKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA69</accession>
    <name>A0A2I2GA69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705055.1">
        <property type="nucleotide sequence ID" value="XM_024849325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA69"/>
    <dbReference type="GeneID" id="36557024"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437271"/>
    <dbReference type="OrthoDB" id="2522565at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014169846" evidence="1">
        <location>
            <begin position="28"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="478" mass="53506" checksum="838F9CF63C91AABB" modified="2018-02-28" version="1">MAKKAAMRLVLVAGLLSAVILVAKLQSHHLDLQTAFLSTHHFAVGRYGQSHRNAGKSETACSGVPDREAWSYCRDGKPADEDGRGPTFEDEISQGHHILYSVSSADREYFEIDFGRRTVINPNIIPHPELPDTWIVTAQLHNPPSARMASVWFAELVCNAAFSEDKRLLGCLEPPLQLPIPATFGDSSKCVGDISHFSLSVGPHDARVFYGPEIPYTLYGSNSFFTCFGQWISDFRILVDWGLDTVHEHEFRQYRELQRPWPWNAVEKNWFLFWDDVGQMFIHHDIAPARIFAKLELDGSVGPNLALATTTSDQACLQRFLPQSTDPTESIHQATNSLAITLCARSDQSCRPDTNNTFVLFIIQRKTSRGLRPVYEPYVVLTRRSMPYEIYAVSSKPIWIFGRRTAAKKPDVSSSKSHSDGSEMLYMTSISWKSQGQKYHGYSDDTLFLAFGREDSAAGGIDVTARDLVAELGMCAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC55</accession>
    <name>A0A2I2GC55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_144811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705761.1">
        <property type="nucleotide sequence ID" value="XM_024842492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC55"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC55"/>
    <dbReference type="GeneID" id="36550189"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_144811"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000063">
        <property type="entry name" value="MFS multidrug transporter, putative (AFU_orthologue AFUA_2G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="133"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="557" mass="62318" checksum="5E40B4539F5CBEB2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDE2</accession>
    <name>A0A2I2GDE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_425219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706228.1">
        <property type="nucleotide sequence ID" value="XM_024847616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDE2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDE2"/>
    <dbReference type="GeneID" id="36555315"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425219"/>
    <dbReference type="OrthoDB" id="4504136at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014183902" evidence="2">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="173" mass="16703" checksum="303EB77F0AC719B5" modified="2018-02-28" version="1">MRFTLLSSAAFCGLFLSAAAVPIAAIPRSETPAIADDLAHTADAGEHGTGFPGAGIPEAINPGVGAPGAGTPGAGTPGAGTPDAGTPGAGTPGAGTPGAGTPGATQPGNPTGVGSDGRPCGGRNPDGLVNGALDGVNTVLCEGAPETPLDTICWRRAENLANDKDDFRWFSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDG8</accession>
    <name>A0A2I2GDG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_474405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706159.1">
        <property type="nucleotide sequence ID" value="XM_024853136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDG8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDG8"/>
    <dbReference type="GeneID" id="36560834"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474405"/>
    <dbReference type="OrthoDB" id="4526765at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014154599" evidence="2">
        <location>
            <begin position="25"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="325" mass="36739" checksum="61A308B67772B563" modified="2018-02-28" version="1">MNLTSKQILTLLISNFIVLQHASAWVLDKRCDDLGYGDLVRRGMAKALDMAQAAQDTLQALKDGTHNEAQMDLFEYMFSFAVEGNGNNRRLKMDEWERIVNTYTEVLKFAPVRQPDEDIPTTEVVIYCDYSRYIEGQSCSGKKKRNLACDKDTSLTNKINFVWRQCKSTVAMVPAMALTSSNGSRRFAQMDLCGWYLRFVSTSKKQFWSDISAKSILAKPLHEVFNARYLRSEMDASALLDHTILHELTHALSQDDTDDVGGMRSYGWRRSVEIGKTSKFWRNADNYAYFGLAARMISPRDGTSAARPNKDGSTSALTVASEQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDR5</accession>
    <name>A0A2I2GDR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_464059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706351.1">
        <property type="nucleotide sequence ID" value="XM_024852218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDR5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDR5"/>
    <dbReference type="GeneID" id="36559916"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464059"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="4"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat" evidence="4">
        <location>
            <begin position="200"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="465" mass="52376" checksum="BFC56E32E10421E0" modified="2018-02-28" version="1">MSLSLPNDILLLVGEFLEEHQDRYNLVFVCRRFHDLLLRLVYRRATLKNASQTRSFLSALLRRPELARAVRSLHFDDWNQTPSPSPSSSSQNMDWSPFRNWAQTISQSEEELAQWEQDLLNDVEEAWIALALPLVNNLRQLRLVYPKESVYLDRTLSRALKGEKPFDDRPAFRVLQEVSLGHMGNEGDTKGSFAPSQISSFFQLPSMRALSADSVVESSSSPDNEHEQTTEMPQSVSSNISEITLYSSNGSKGMEGLIASCPSLRSFKYQHSDSHLLSEGYRPSEFARSLAASKGSLETLWLDSFGTHLPFTIAGANETHDEWFGSLADFTALKDIRIRLPNLLDVRYQFEPSTALPDVLPPSVQTLSVEGCKEMSLRMLIGQLKMVLGQRQKRFVGLRRLDIEGFFHDEEDEDASGYDAHAANPGGEKVIKSRVYEMTEALHTSCAEAGIELHLRDRDCPATMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDU7</accession>
    <name>A0A2I2GDU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_356016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706388.1">
        <property type="nucleotide sequence ID" value="XM_024844121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDU7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDU7"/>
    <dbReference type="GeneID" id="36551821"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356016"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22977" checksum="A4A943BE7B9E1D99" modified="2018-02-28" version="1">MGLEEEPSKVPLEAHIMSKCPDAQECLQELVLPAMEQISDKVDFDLSFIATVSHKTSDIVCKHGPGECIGNILILCAQNLPFPDGSDSRMPTIRSLGFANCLIGSYEDIPDRELVHHCALEHGIDFDALNHCASQQEDDPGDDGLSGLALLRESALHSADLGVKTSCTLRLDESTWCVRDGGVWKDCAEDGEGSEVSVLVDEINKLWGERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEG9</accession>
    <name>A0A2I2GEG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_455515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706598.1">
        <property type="nucleotide sequence ID" value="XM_024851534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEG9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEG9"/>
    <dbReference type="GeneID" id="36559233"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455515"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="439"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="534" mass="58822" checksum="0BA8749A925F13A1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF33</accession>
    <name>A0A2I2GF33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_80129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706763.1">
        <property type="nucleotide sequence ID" value="XM_024855390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF33"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF33"/>
    <dbReference type="GeneID" id="36563097"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_80129"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="217" mass="25005" checksum="99A23325C889FE5C" modified="2018-02-28" version="1">MVTGRSCVSFTMRTYISRPFRCYEEALHSRGYSGEVLARCETAYTRWVGAYTLRSNDLLREWKKWPSEGRDPDEVRSTLRVHLLDYLIKDLGNSPTTLLTQYILARGELIDREEETTYTVIEYLLTEGGNINAPVAEDGCTALHRLCQTYRTRIEAWESISTDAVKAQREFFRFLIHKGADWSIVIGGRTAWDMLVKDAASCYGQLGDWERVLKSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF44</accession>
    <name>A0A2I2GF44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_348275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706749.1">
        <property type="nucleotide sequence ID" value="XM_024843669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF44"/>
    <dbReference type="GeneID" id="36551369"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348275"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="29"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="486" mass="54993" checksum="036D88691C6A7245" modified="2018-02-28" version="1">MPVEKESGAADTLGPEEEKMLVRKIDMNLMPLLIISYGLQYLDKTSLSYSAILGIREDLNLVGQEFNWASSIFYIGYLVASYPISLGFVRFPLGRYLSLLMYDFLLWGIILTLHAVAENYAGLMVLRTFLGIFESAISPGFSLITGMWYTPKEHMSRHSFWFAGNAVASIIGSMIAYGILHYTGGFSQWKLLFLIFGLITIAWSVVLWFYLPNSPSNAHFLTPTEREFASLRPKKFQRTTQTKQWDKKQFIETFQDPKTWWFLVFSFVICVPNGGITSFNSIIINSFGYDKFQTILMGLPAAAFQLTTVILAAVFTTLFRKSRLWAVIGTFLLAMAGVLMIKLLPTEKKLSRLAGYWLVTAVSPAFPLMMSLFASNTAGFTKKSTLVALIFVGYCVGNFVGPQFFKNNEAPAYGTAYTTILTCFAITIVMALIFRIYLSWTNSRRDREQGVHIDPEDSREIDLHADEELEGVDETDMQNRGFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF95</accession>
    <name>A0A2I2GF95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_376057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706833.1">
        <property type="nucleotide sequence ID" value="XM_024845346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF95"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF95"/>
    <dbReference type="GeneID" id="36553046"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376057"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF54">
        <property type="entry name" value="GLUCOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB51531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="512" mass="56250" checksum="27FD7350981341FA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFI5</accession>
    <name>A0A2I2GFI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_422633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706945.1">
        <property type="nucleotide sequence ID" value="XM_024847454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFI5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFI5"/>
    <dbReference type="GeneID" id="36555153"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422633"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="240" mass="27621" checksum="392AEF55F9981599" modified="2018-02-28" version="1">MSSTDDPFSLRDMSYEEFTSSQIPLYHGPTVNIKIGDSAYKVSKILLCKHSPYFRAMFEGRFMEAEQQSVELQEIDGVVTNRAFQLLLQWMYLGHVIPADEVATSWITLLVEFARLADFLKINEVDIAIARFIKDSIAVNSPWEFLRPPHANIHHIIPEHIQAASRLPRRHVVRRLFASASFDAYMHSVDFKFANEVRDIQDFAADLLDEVKVALRSVRNGGAMCVFRDPFDGREREFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFL8</accession>
    <name>A0A2I2GFL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_487808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706929.1">
        <property type="nucleotide sequence ID" value="XM_024853964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFL8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFL8"/>
    <dbReference type="GeneID" id="36561665"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_487808"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="10"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="631" mass="70743" checksum="978DC417ED7D5ACA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG76</accession>
    <name>A0A2I2GG76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_433785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707187.1">
        <property type="nucleotide sequence ID" value="XM_024848575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG76"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG76"/>
    <dbReference type="GeneID" id="36556274"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433785"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="288" mass="32228" checksum="2F890E42FEB02365" modified="2018-02-28" version="1">MTRFRFGDPDESASDLDDDTAGLPFPEPLSRASFLTPDFDAAQYLSSLTNRHQSLEDLRQELRELDQALSRQLLDLVNENYQDFLSLGTALHGGEEKVEQVRVGLLAFQRDVQAIRDKVEARHQEVAQLIEEKRRLKGNTNVARALLDFADRVEELERRLMIGGAPAAEDADSDLLESETDGDDDEELSSGASTTPLVSLKRLEHHIQKLVYLTRLSSRIGDEHPFLLGQQPRLSKIKSAVLLDLKTALEQASHAGEKRDTKTLAVLRLYKLMGEDTSAVTALKNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGQ6</accession>
    <name>A0A2I2GGQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_453588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707364.1">
        <property type="nucleotide sequence ID" value="XM_024851369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGQ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGQ6"/>
    <dbReference type="GeneID" id="36559068"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453588"/>
    <dbReference type="OrthoDB" id="3534988at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="579" mass="64023" checksum="9E739EBE3D12A831" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHF8</accession>
    <name>A0A2I2GHF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_351549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707579.1">
        <property type="nucleotide sequence ID" value="XM_024843873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHF8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHF8"/>
    <dbReference type="GeneID" id="36551573"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351549"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="74"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB52277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="608" mass="66939" checksum="FEC0759C709AA3AC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHN8</accession>
    <name>A0A2I2GHN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_348709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707676.1">
        <property type="nucleotide sequence ID" value="XM_024843694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHN8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHN8"/>
    <dbReference type="GeneID" id="36551394"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348709"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="420" mass="48118" checksum="5EF47371AE103C7F" modified="2018-02-28" version="1">MKPEWWPGEDHELFTEWAIAQGIVVNGVNPARFPGRGLGMIATRAIEEGEAIVTVPLRTMFTPNSIPSSFSSKFPDGTPVHALYAAFFTNGDPENLKHYEPWRKTWPSLKDFEDGMPILWPSYLRGSKTSVDSSSEQTFLPPSISGSWSSIQKGKSEFHYETTHQNLLSQQESRLRDAWDAVVAVFPKTDWETFSYHWLIVNTRSFFFLMPGEEAPEDRNDAMALLPFADYFNHSDVACNVKFNGLNYIFRATKHYDEGEEIYMSYGPHPNDFLLTEYGFFLDHNESETLYLDDIIFRDLSKTLQEELEFEQYYGNYQLTAEGVCYRTEIAACIKYMAVEDWRNYTLGYSTKNFDAAKSEAIIREWIKTYANEADTVIASLEKAGSQEADLKGSDKVKALLKRWTQIKTLCDQALQTVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHW8</accession>
    <name>A0A2I2GHW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_349420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707785.1">
        <property type="nucleotide sequence ID" value="XM_024843734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHW8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHW8"/>
    <dbReference type="GeneID" id="36551434"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349420"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00867">
        <property type="entry name" value="Trans_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="725" mass="81383" checksum="D606566E3AE0D0C8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIB3</accession>
    <name>A0A2I2GIB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_434337</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707927.1">
        <property type="nucleotide sequence ID" value="XM_024848693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIB3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIB3"/>
    <dbReference type="GeneID" id="36556392"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434337"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB52625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="439" mass="48984" checksum="EA5F5661EE514168" modified="2018-02-28" version="1">MPSATGENWEKYKKNFADEEEPEKKITPLTDDDIAVLKTYGAAPYANALKKLEKQIKDKQNSVNEKIGVKESDTGLAPPHLWDVAADRQRMAEEQPLQVARCTKIIQDEKDTDKSKYVINVKQIAKFVVNLGERVSPTDIEEGMRVGVDRNKYQIMLPLPPKIDPSVTMMTVEDKPDVTYGDVGGCKEQIEKLREVVEMPLLSPERFVNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDARGNIKVMFATNRPSILDPALMRPGRIDRKIEFSLPDVEGRANILRIHAKSMSVERDIRWELISRLCPNATGAELRSVATEAGMFAIRARRKVATEKDFLAAVDKVIKGNLKFNSTATYMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJB3</accession>
    <name>A0A2I2GJB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation machinery associated TMA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708271.1">
        <property type="nucleotide sequence ID" value="XM_024852988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJB3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJB3"/>
    <dbReference type="GeneID" id="36560686"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472852"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="69" mass="7425" checksum="7755764E81F2E1FC" modified="2018-02-28" version="1">MGGASREGGKVKPLKAAKKDKKDLDDEDLAFKEKQRAEAKAKKDLLDKTQGKKGPLNTGSQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJG4</accession>
    <name>A0A2I2GJG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P170DRAFT_423797</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708317.1">
        <property type="nucleotide sequence ID" value="XM_024847529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJG4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJG4"/>
    <dbReference type="GeneID" id="36555228"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423797"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19 22" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PLB53015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="638" mass="70132" checksum="57D68801D404CE03" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKR4</accession>
    <name>A0A2I2GKR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_435097</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708768.1">
        <property type="nucleotide sequence ID" value="XM_024848858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKR4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKR4"/>
    <dbReference type="GeneID" id="36556557"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435097"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB53466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="184" mass="20763" checksum="F918F2C8527A40E3" modified="2018-02-28" version="1">MLKIWSMKQKQQQAENAEGAAGKKKKKVTAAQLRVQRDLNELTLGSTMKMSFPNPDDILNFTLTIEPDEGMYKGGAFHFSFAVNQNFPHDPPKVKCSQKIYHPNIDLEGNVCLNILREDWKPVLNLNAVIVGMQFLFLEPNASDPLNKEAADDLRQNRDAFKRNVRTSMGGGAVRGVPYERVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL67</accession>
    <name>A0A2I2GL67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_441911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708924.1">
        <property type="nucleotide sequence ID" value="XM_024850425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL67"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL67"/>
    <dbReference type="GeneID" id="36558124"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441911"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="15"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="465" mass="51972" checksum="BA03F9827B6621AA" modified="2018-02-28" version="1">MGIRKQFASALMGSFVLLQILFLANMCYLYATQFRSSTRFHNMKILYVDYDGGAVGQSVLDAYANLRGDSFPTLQHSDAAAFPTPREVRAAVCSGDYWGAVYANSQASSNLTSALQGDQALYNSDSALTYVWNGARYPAMSMSAVYSSLQTLFAATRSMYYARNASEVLPFTNLTSPTALQALLDPIQATEINLKVTEQGTRVLYNTVSIVMPIIQQFFFMMALNGISSQFQILTRLGWHANGLLRMCISAAYTFVGALCMVAYIWSFRESWEVNGNHFALSWMIIWLYMHINFLIMDILTTFVPMQFMPFCVLTWVILNVASTISPFELSPGFFHWGYALPAHETYQVLVQIWSDGCESQLHRALPIMFSWWIVALGTAIFSLHHRCNTAVAAERAAMQPASKDFESSAPTVSDGEATRQSGSRHPSIEQILPQRRRDTAESIHLEQLAYGPSFPTPLGGDHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM65</accession>
    <name>A0A2I2GM65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_451884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709283.1">
        <property type="nucleotide sequence ID" value="XM_024851231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM65"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM65"/>
    <dbReference type="GeneID" id="36558930"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451884"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="714" mass="79596" checksum="1B5B3DB54CA7C73C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM79</accession>
    <name>A0A2I2GM79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_442174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709290.1">
        <property type="nucleotide sequence ID" value="XM_024850441.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GM79"/>
    <dbReference type="GeneID" id="36558140"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442174"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF48">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SDGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="4"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="910"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2372"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="910"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="942"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2464" mass="268705" checksum="24B8AE212D7096D3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMH2</accession>
    <name>A0A2I2GMH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_372743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709390.1">
        <property type="nucleotide sequence ID" value="XM_024845211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMH2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMH2"/>
    <dbReference type="GeneID" id="36552911"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_372743"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF85">
        <property type="entry name" value="INHIBITOR (TFS1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="191" mass="20912" checksum="64213BEF7F2D6410" modified="2018-02-28" version="1">MALASYAQELSASLAKAGLVPGSAPLIPDNFTPTVQLKVNFGEKAVELGNLFRASECKVAPSVEFTPEENVDPSTRYMLFLIDPDAPTPDDPKFAYWRHWVVSGLAPGQGIDSGMNLTEYLGPGPKDDSKPHRYLYLLFREPAGLSLDKEDVGGEEFVERRSFKAAEFVDKFKLVLVGINWMLGAGDGWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMW6</accession>
    <name>A0A2I2GMW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Scaffold protein Tuba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_469677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709516.1">
        <property type="nucleotide sequence ID" value="XM_024852667.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GMW6"/>
    <dbReference type="GeneID" id="36560365"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469677"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000083">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000053">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="8">
        <location>
            <begin position="1189"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="9">
        <location>
            <begin position="1447"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="761"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="799"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="875"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="949"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1268"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1697"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1819"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1697"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1741"/>
            <end position="1752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1936" mass="211815" checksum="8819F5617CA5B584" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN56</accession>
    <name>A0A2I2GN56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_431949</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709619.1">
        <property type="nucleotide sequence ID" value="XM_024848153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN56"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN56"/>
    <dbReference type="GeneID" id="36555852"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431949"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB54317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="140" mass="14734" checksum="4CAD3C07CC31C45A" modified="2018-02-28" version="1">MAYPARATSMFPGSSAAPSFRQPSSHNAQQSSALTARIASKKSELDSLKQLRDMSSALAAQMQALENKLGTLKDGTEAIACVLANWDSVLQAINMASTKAAAVHERAAPGSDAETQDGVPAMPSILVRIPADQPEEPRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNH7</accession>
    <name>A0A2I2GNH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Outer mitochondrial membrane protein porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_397831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709711.1">
        <property type="nucleotide sequence ID" value="XM_024846194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNH7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNH7"/>
    <dbReference type="GeneID" id="36553893"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397831"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB54409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="342" mass="36712" checksum="F1FFD84E64B5723E" modified="2018-02-28" version="1">MSAPAAFSDIAKAANDLLNKDFYHTSAASLEVKSKAPNGVTFNVKGKSAHEGPIAGSLEAKYVDKPTGKRPLRRKPPDPNCTPLRESKPMNFMVSCGLVSSKRLLFFFTSRISDHAVRLIFRPRSGLTLTQAWTTANALDTKLELDNNIAKGLKAEILTQYQPAKQSKGAKLNLHFKQPNLHARAFFDLLNGPSANFDAVLGHEGFLVGAEGGYDVQKAAITKYSAAVGYSVPQYTAAITASNNLSVFAASYYHRVNAQVEAGAKATWDSKVGNSVGLEVASKYRLDPSSFAKAKINDRGIAALAYNVLLRPGVTLGLGASFDTQNLNQAAHKVGASFTFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPD5</accession>
    <name>A0A2I2GPD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_470182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710039.1">
        <property type="nucleotide sequence ID" value="XM_024852723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPD5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPD5"/>
    <dbReference type="GeneID" id="36560421"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470182"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="136" mass="15971" checksum="066A7427E1ACDF1D" modified="2018-02-28" version="1">MNIGELFLAGALKCPMYRLRIVMNFPGLLMFAKTRGMHGLSHFDQKGEKMRDYYKDPWHGRYYAEHEARTDGYLRGKAQKEVRTFIKVKTSLRENGEAEVRVQESEQMVAWLKASPNAPRMLPSRRFHVSQDRHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPK1</accession>
    <name>A0A2I2GPK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_470250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710112.1">
        <property type="nucleotide sequence ID" value="XM_024852729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPK1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPK1"/>
    <dbReference type="GeneID" id="36560427"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470250"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="31423" checksum="B22BB57F6C95C95C" modified="2018-02-28" version="1">MAARRVVVAGGNGFLGSRICKSAVARGWSVTSLSRSGEPRWDTVTGSRERPDWSRSVEWAKADMLNPQTYKPFLNGATVVVHSMGILLEADYKGVVQGREPLLSGLQKVFSSSRLGSQNPLQRREGEALRAQEKNGQLTYELMNRDSAIALAQESSNEHVPTFVYISAASGAPVLPSRYITTKREAETTISADLPELRSVFMRPPFMYDSSRKFTMPIALGGFVGSQVNALLGNRLGFLGTMVDKPFQVDMVGEAVVEAMEDETVRGAVGTKRMEALATKAWRKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPK2</accession>
    <name>A0A2I2GPK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_25099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710109.1">
        <property type="nucleotide sequence ID" value="XM_024843025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPK2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPK2"/>
    <dbReference type="GeneID" id="36550724"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_25099"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="222"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="487" mass="53474" checksum="132DBF1CB1BDA1CE" modified="2018-02-28" version="1">MSRTPLQWHTVYPDGWYFDGRRRVSDDENQRMASTSNNPFSPGPHPPQFLHPDNRGYDPTMISPSQPRSSVYGRPRESAAEPEVAFSSGSMNSMAPHGAQRSNLFKVVDYGGAHGSYDHRGSIGSSGRVNDMDSQYSSSSTTFPSPVHSDKSMVLYPQNVPFAKQQQQQQQQHQQQQHPLPPPQHSPPRHTTSSMPLGFEKLLNHSPSPSPPPSLPPPRRPSSSSRYHLHIRQQPLAARACGAGDRDRRPVDPPPIIQMLLTDFDPHSDTDSDILQDPRFAVGCLLVPVSGSADLDAEPGVRENRLAQRDGGGGGGQTTPLLSGKAFVSPFYVGADPDPDTAPAHPSSIESLYTTAASSASTTSTTTTTRTTPTDPRHRHTHHQHHRPPPHPSFQPPATFYIFSDLSVRTAGLYQLQFRLMNWGAVEDTGQSMGILAEAWSDPFRVFPAKDFPGMRDSSALTRGLKELGFVELKTRGRGEGKGRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPP2</accession>
    <name>A0A2I2GPP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_26140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710147.1">
        <property type="nucleotide sequence ID" value="XM_024843076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPP2"/>
    <dbReference type="GeneID" id="36550775"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_26140"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014176777" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="51" mass="5951" checksum="C9BFE7E6643F256E" modified="2018-02-28" version="1">MACLRILLPAPWFSLVSCHLIARQERYYFLQDFGSINHGVFRNRGKPFPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPV0</accession>
    <name>A0A2I2GPV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_483704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710206.1">
        <property type="nucleotide sequence ID" value="XM_024853905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPV0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPV0"/>
    <dbReference type="GeneID" id="36561603"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_483704"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38943" checksum="892BAF037276ED95" modified="2018-02-28" version="1">MAPAALGSPRLAPTVVGPTTKKATRPTRQLPRSLIEGAKVEKKMPFDPDTHIIYQPPEKIHLMSELGLEGAGISPNAISEPFPLFSEAAIKQMRAEIFSDPVLADCQYASTFCTNMIRGMGHQRAPFVYDAWKSSRLLSSVSEVAGVDLVPAWEYEVANINIAVKDDDEAESSIDQMVDVKDDNTAAFGWHYDSFPFVCVAMLSDCTHMVGGETAVQLPSGDIKKFRGPAMGYAVVMQGRYLQHQALKAIGGRERISMVTPFRPKDPLVRDEIVLVGVRGISNLSEVYPQYYEYRLDVLEERIRARKKAERARETAYRPFSLAEERDWIRAQRDYLDSMLNEMYEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPW8</accession>
    <name>A0A2I2GPW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-amylase</fullName>
            <ecNumber evidence="5">3.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">1,4-alpha-D-glucan glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P170DRAFT_398690</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710221.1">
        <property type="nucleotide sequence ID" value="XM_024846240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPW8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPW8"/>
    <dbReference type="GeneID" id="36553939"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398690"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000037">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014133815" description="alpha-amylase" evidence="20">
        <location>
            <begin position="16"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="21">
        <location>
            <begin position="28"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="45"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="255"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PLB54919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="494" mass="54561" checksum="F9C604A481895387" modified="2018-02-28" version="1">MKWSLLSLLASTALAATPAQWRSQSIYFLLTDRFARDDGSTTASCNTEDRKYCGGTWQGIIDQLDYIQGMGFTAIWITPVTAQLTEDTEYGDAYHGYWQQDIYSLNENYGTADDLKALADALHERDMYLMVDVVANHMGYAGAGDSVDYSVFNPFNSQDYFHSYCPIEDYDDQTQSEECWLGDNSVSLPDLDTTKSEVQDIWYDWVGGLVSNYSIDGLRIDTVKHVQKDFWPGYNDAAGVYCIGEILDGDASYTCPYQEVMDGVLNYPIYYPLLNAFKSTSGSISDLYNMINTVKSDCPDSTLMGTFIENHDNPRFASYTDDISQAKNVAAFTILADGIPIIYAGQEQHYAGGEDPANREATWLGKYNTDSELYKLIAASNAIRNHAISTDEKYVNYQNYPIYQDKSTLGMRKGYDGAQVITVLSNQGSSGSSYTLSLDNTGFSSGDKVTEIYTCTALTVDSDGKVPVPMDGGAPRVLFPTEKLSGSGLCSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPZ1</accession>
    <name>A0A2I2GPZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_27978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710247.1">
        <property type="nucleotide sequence ID" value="XM_024843186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPZ1"/>
    <dbReference type="GeneID" id="36550885"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_27978"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014131036" evidence="2">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="177" mass="19384" checksum="4A0D46C0E1433931" modified="2018-02-28" version="1">MPRGSFHWHSSLWRFLFSSSSSSYLTVGGRYPGILLYLVPCVPRTVQKIPVARKSTYAVVPPLRSTRPKFETASGKGYPPMQIPDSYLPPGPNSVTTSSPRRVQPHATFHGGDGMEGRKRQRLTTIDSDDIIAVECRRERGGDETEEGKADESTGNNRRSGGSDGQPVVLLYCACVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ51</accession>
    <name>A0A2I2GQ51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_432528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710304.1">
        <property type="nucleotide sequence ID" value="XM_024848284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ51"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ51"/>
    <dbReference type="GeneID" id="36555983"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432528"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB55002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="237" mass="27182" checksum="21E6DCE5B1368813" modified="2018-02-28" version="1">MKLNISYPANGSQKIIEVDDERKLRPFMEKRMGTEVPGESLGDEFKGYLFKITGGNDKQGFPMKQGVLLPTRTRLLLAEGHSCYRPRRTGERKRKSVRGAITGFDLAVLALSIVKQGEGEIPGITDTVVPKRLGPKRATKIRRFFGLDKKDDVRQFVIRRTVTREGKQDYTKAPKIQRLVTPQRLQRKRHQSAIKRRRAEASREAANDYAKLLAGRVHEEKAKRDELRKRRASSMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ96</accession>
    <name>A0A2I2GQ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_452568</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710350.1">
        <property type="nucleotide sequence ID" value="XM_024851285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ96"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ96"/>
    <dbReference type="GeneID" id="36558984"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452568"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="219"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB55048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="354" mass="38645" checksum="9D54C8C6943A1E61" modified="2018-02-28" version="1">MSTDNGGAPPVGQENINTDIVTLTRFLTEEQTKVPEATGDFTLLCHALQFAFKSIAYYIRRASLINLTGLAGSSNTTGDDQKKLDVIGNDIFISAMKGSGKCRILVSEEEDEAILFDEHPNARYAVVCDPIDGSSNLDAGVSVGTIFGIFKLPDSLLGPGKKVTAKDVLSPGTEMVASGFTMYGASAQLVITMRNGGVNGFTMENSLGEFILTHPNMQMPAKRGIYSVNEGNSMYWEEWTNEVFRSMKFPGEGKKPYSARYIGSMVADAYRTLLYGGLFAYPADSKSPKGKLRILYECAPMAMLFENAGGLAINSRAERLLEVVPEHIHDRSGVFLGSKDEVQRVIDTYNKHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQJ2</accession>
    <name>A0A2I2GQJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_421748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710449.1">
        <property type="nucleotide sequence ID" value="XM_024847387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQJ2"/>
    <dbReference type="GeneID" id="36555086"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421748"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="272" mass="30960" checksum="C54A98B96359923F" modified="2018-02-28" version="1">MEELLGSNRPIKRVSRKALYTRLEARINYLRDFLDFNTADVEALTTGSKYIKALIPAIVNIVYKKLLEQDITARAFHTRNTADETPIEDFYSEESPQIMRRKMFLRWYLTKLCSDPTQMEFWRYLDKVGIMHSGSERMHPLNIEYIHMGACLGFIQDIFTEALMSHPHLSLHRKTALVRAISKIIWIQNDLIARWRIRDGEEYADEISTIPTDDKEGYVGEKKVLGDSSTSASSSDDDRSSIASSCAPSAAPACPFADLAKSVSETKIWAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRT3</accession>
    <name>A0A2I2GRT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR/FUN34 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_443338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710894.1">
        <property type="nucleotide sequence ID" value="XM_024850538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRT3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRT3"/>
    <dbReference type="GeneID" id="36558237"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443338"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32009" checksum="9FE122A15D96AFB6" modified="2018-02-28" version="1">MSSPTDSPEKNELKNTTTDASTTDSNPPLGHAQTNQSSHVDYGHFGPLAHVNTAETTLPAFGGEFQPGLYRSPKNRKLANPAPLGLCAFALTTFMLGCINMQVRDITEPNMVVGVAFSYGGLVQLLAGMWEMAVGNTFGATVLSSYGGFWISLAITFTPGGFGVMSALEEADGGKAGMFYDSFGLMLMGWFIFTTLMLLCTLKSTFAFFTLFFVVDIALLLLAIGYIHRGPDGQPAAKIIKAGGLFALLGAFLAWYNAFAGVADDSNSFIIVPVVHFPWSEKGKESRRARVRAANEQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS80</accession>
    <name>A0A2I2GS80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_433233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711029.1">
        <property type="nucleotide sequence ID" value="XM_024848432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS80"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS80"/>
    <dbReference type="GeneID" id="36556131"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433233"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF432">
        <property type="entry name" value="Y, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013987335" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="489" mass="54053" checksum="2FA8EB1DA4454F86" modified="2018-02-28" version="1">MLRLLALAATFGLSLAASQTPLLSSPTDDFRVIHSTQFPEYSVRIRQQNESICAAGSAQYTGWLNIGPKHLFFWYFESQNDPVSDPLTLWMTGGPGDSSMIGLFQEIGPCLVNEHANGTVHNPWSWSRNSSLLFVDQPVGTGFSYLDDGEDLPVDSEQAAVDMHRFLQLFVSEVFPHLKPLPVHLSGESYAGHFIPYLGARIIQQNQIYPSQPQVNLKSCLIGNGFMSPRDSFYGYWETPCTTNPGVAAPVFNTTRCDIMAANMPRCMHVSEVCVRNPDPAICDAARSVCYEGVVGWYDEEAGAGGRNRFDITAPCAIDEMCYIQSARIETYLNSAAVWTSLSPPSEVEEYRFVSQAVIDAFDTSADGMTSTSELVVFLLEQGVDFLAYQGNLDLACNTAGNRRWAESVVWKGQVEFTAREMRVWRAFVEEKGGMETVGRMKEVKVEGGDGKVRFAFVTVDGAGHLLPQDRPDVALDMMVRWITGASFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS92</accession>
    <name>A0A2I2GS92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_453023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711044.1">
        <property type="nucleotide sequence ID" value="XM_024851325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS92"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS92"/>
    <dbReference type="GeneID" id="36559024"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453023"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF142">
        <property type="entry name" value="ANKYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="188"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="626"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="659"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="754"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="953"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1218" mass="134625" checksum="C1142DB0092108F7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSG0</accession>
    <name>A0A2I2GSG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_433286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711105.1">
        <property type="nucleotide sequence ID" value="XM_024848450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSG0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSG0"/>
    <dbReference type="GeneID" id="36556149"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433286"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="321" mass="33565" checksum="AAC2A8B247CEF522" modified="2018-02-28" version="1">MSNSFHETAASAVQARNRIRHHIYQTPLIPARKTGQVFNANILFKAENFQLTGSFKLRGALSKVSAQTSSGRLITASSGNHGIGAAFASQALSRDLTVVLPETVMPSKLEKIKSFGVEVILHGAETGLAEQHAQQLAASGAYTYISPYNDADIVAGQGTIGLEILEQCDQVDNVFISMGGGGLISGIGSVLKAFSPRTKIYGVAALNSRALAASLAVGRVVETDHLPTLAEAVAGGIDEDTITLPLASSVVDQVVECDEAEIVEALKTLAFDENMIVEGSAALALAGFTKVARELAGQTSIILLCGANVDQGVVKRTIYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSJ1</accession>
    <name>A0A2I2GSJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_396557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711144.1">
        <property type="nucleotide sequence ID" value="XM_024846125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSJ1"/>
    <dbReference type="GeneID" id="36553824"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396557"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="29"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="504" mass="55012" checksum="4F23E958EB882257" modified="2018-02-28" version="1">MASSSASISAAPIPPEDVTKILRKVDRRLIPILFFTYMLNFMDKTILSSASVFGLIDDTGLVGQQYSWVSSIFYFGYFFWEGPTNILIPRLPVAKYLTANTLFWGAVVALTAACVNYGGLLAVRFLLGVAEATITPAFMFITTSWYTRDEMPVRTGIWFSGNSIGGLVASLLAYGVGHIAAPLNPWQWMYIILGVATFLWAFVLLLFLPDSISTARFLTPSERTLMTHRVLIAGTGRTEKTAWSWTQARECLIDPKTGFLFSIALLTQIPNGGTQNFSNLVIKSFGFTSLQSTLINIPTSIISAATIAVTGWMAGRLQRATCLLIVGIVLLSITGSAIIYARAHVPLGAQLFGYFLLATGPGALPLTMSLVQANYKGVSKKMTMTALMFVAYCAGNIAGPHLFRSSEAPTYQTSFRAILVCYIIAGAMALALRGYLAWLNGRRDATEGVRGDAGLAGVVTVGKAQQESEQPRQDVSELVHSVELRPEDYEDVTDWKTVGFRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR80</accession>
    <name>A0A2I2FR80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative vacuolar aspartyl aminopeptidase Lap4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_441596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698442.1">
        <property type="nucleotide sequence ID" value="XM_024850350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR80"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR80"/>
    <dbReference type="GeneID" id="36558049"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441596"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="514" mass="55560" checksum="818E406F611F7645" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRB8</accession>
    <name>A0A2I2FRB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_514458</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698486.1">
        <property type="nucleotide sequence ID" value="XM_024855208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRB8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRB8"/>
    <dbReference type="GeneID" id="36562914"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514458"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="193"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB43184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="415" mass="45326" checksum="C40FB781E996B09D" modified="2018-02-28" version="1">MADTDVVSSTEQTPLPTESIPSDQPPQPDATTALTVAAGGDTTTTEVAVADADGQKKTKKIIRRKRRPARPQIDPATIKSEPPPQTGTTFNIWYNKWSGGDREDSILSKHAAPSRCNVAKDSGYTRADKVPGSYFCLFFARGICHKGHECEYLHRLPTLHDLFNPNVDCFGRDKFSDYRDDMGGVGSFMRQNRTLYVGRIHVTDDIEEVVSRHFAEWGQIERIRVLTSRGVAFVTYSNVANAEFGKEAMAHQSLDHSEILNVRWATVDPNPLAQKREARRLEEQAAEAVRRALPAEFVAELEGKDPEARKRKKIEGSFGLQGYDAPDEVWYTRTKQLEDAGRTGGQLEAPDQPLMLEAAASSSTEVPAQESASGGIFSSSTVAALRGLSGGNVTTKPAPQASGPLVGYGSDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRM7</accession>
    <name>A0A2I2FRM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_451345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698585.1">
        <property type="nucleotide sequence ID" value="XM_024851179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRM7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRM7"/>
    <dbReference type="GeneID" id="36558878"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451345"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="328" mass="36976" checksum="829786D53B475845" modified="2018-02-28" version="1">MANNYIDEATFVAVIWVCLTITFFFLLAQLLLQYQIDRKWRTNDVLLLAAWLLFLGNCIVWSVCHKQMFLVSTFTTGAIDYATLPPNIASVMERYLRGQLAGYLSYTSLWLVKLSFVFFFRHLGNRFRAQRILWWVVLAFVISCYAVTLGVLDYACEMASFEESLELCASAHSVWYERVSLKISTSMDIVSDAAIIVLSGNVIWRVKINLWKKLALIGVSFLTAFIIITALVRLLLSVSGTGILSAAWLVFWNAIEICVAIMMACLASFWTFYTKLKRSARDLPGRGGLFSPPRDYASLERPILMTGSLHGGDKHAQSAVSVQSHISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS14</accession>
    <name>A0A2I2FS14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_486331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698715.1">
        <property type="nucleotide sequence ID" value="XM_024853930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS14"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS14"/>
    <dbReference type="GeneID" id="36561628"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_486331"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="29"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="443" mass="47486" checksum="F0A62ED8B14A2FDB" modified="2018-02-28" version="1">MASEGLPKNQDLSDPETQYILDGNARFRRLGWKRLTVISIVEAIALGSLGLPSAFATLGMVAGVILTVGIGLVAMYAGYNIGQVKLRYPQVGHYADVGQLLLGSVGSKIFVGSFVALLIFVIGSHCLTGAIAFQTITESGVFSVVFSVVSAAILMMLAIPPSFAEIAILGYIDFASIILAIGITVIATGIQTSNGSGTFSTDHSPWSAWPIAGITFSQAIVATNNIVFAYSFAGCLPSFMEDMHTPEDYIKTLWWLGGIQIVIYTLTGSLIYAFVGQEVQSPALLSAGPVISRVVFGIALPVIFISGSINTTVVCRYIHGKVYHDSAARFINTRKGWMTWLGLISLVTVLAWVIAEAIPIFSELLSIISALFVSGLSFYIPPVMWFVLLREGAWYEKHNLQPAVCNLVVFIVGMVVFGCGTYSSIAELVSKFQSGAISKPFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSI5</accession>
    <name>A0A2I2FSI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_441025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698868.1">
        <property type="nucleotide sequence ID" value="XM_024850215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSI5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSI5"/>
    <dbReference type="GeneID" id="36557914"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441025"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB43566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="879" mass="100484" checksum="8878F78423CD56C7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSW4</accession>
    <name>A0A2I2FSW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_61007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699021.1">
        <property type="nucleotide sequence ID" value="XM_024855300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSW4"/>
    <dbReference type="GeneID" id="36563006"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_61007"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="155" mass="18557" checksum="9A96EA3B789AA432" modified="2018-02-28" version="1">MACITRLPWPWEGVHDDFDLAILGAGQMTLRETTAGLFHWGQPGRKELGRKRKETWKPMRRFAVPGLFVDDDIREGVREGGQYRQLWFSSRLFLNSLCRESHERRRGRDETRPRQEPDLFRCESFRVLFFVYIQRLRMVFYRCPNTSPRCSAWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU06</accession>
    <name>A0A2I2FU06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_513384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699425.1">
        <property type="nucleotide sequence ID" value="XM_024855103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU06"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU06"/>
    <dbReference type="GeneID" id="36562809"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513384"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03440">
        <property type="entry name" value="hot_dog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="240"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38131" checksum="4BFF71FD41FE9F59" modified="2018-02-28" version="1">MQQASLSNVLKPALSSSQECIVPLSPDICFGSVTMGGYMPCLAAQYASHYASQRPGLESQASLRSMNAQYYRPLFPARGPVRMALREISVGKAWSTLRVEVFQPTKCTEMAISVDMLYLETHTDPGWICYHTSFKPNGFRRAHSYLKHFIPVDWFPETPFIEQWVTPGWDCAPSGSSLHSKESSNDDGMENDPRARWTTDMIPFIMDASLPPECNFLPSKHDLQLVSMTAFLRYAAAQKKARERGEPNWRDVPNDGSEGFDASIVNVALAMSIDIRQELPAEGVRWLYLRNEVKCIRNGGVHVEATLFDEKMRLVAVSHQTGQFVSAGKKRMKKTESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU09</accession>
    <name>A0A2I2FU09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_367683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699430.1">
        <property type="nucleotide sequence ID" value="XM_024844819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU09"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU09"/>
    <dbReference type="GeneID" id="36552519"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367683"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="405" mass="44182" checksum="96DBB0D583D19366" modified="2018-02-28" version="1">MDSFGIIIVGGGIAGLAAAIALRADDREITILEQSQMHKEIGATISLQPNASKIVEGQWGLSSLLRDQGSMVDEAFEIYNTDGEMQMRIPLATKYGAERMMYHRADLHSVLKHRATADEYPGRPVTVKVSSRVVGCDCEKGVVDLANGEAMHADLIIGADGIKSTVRKAVLGEEVEAKRTGLSAYRTMITTEELRKTDFADVIDPCRSCTTMVMGMDRRLIMGPARNGSIYGIVALVPDESMQESSSNTSWTTAGDRNKMLDTFSAFPEWAQRPLQLAGVVGLWQLRDLDPLSSWYRGRVLLIGDAAHAMLPTQGQGASQAIEDAEAVGAFFAGFEGKNDPKSLDEVERVNRAVFECRHERATTIQAYSRQAAKPATDPGDTRVKMSPAEFMDYNCSYGGAIDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU19</accession>
    <name>A0A2I2FU19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_479878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699408.1">
        <property type="nucleotide sequence ID" value="XM_024853730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU19"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU19"/>
    <dbReference type="GeneID" id="36561428"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479878"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="371" mass="41428" checksum="8ADCED2E9AC84183" modified="2018-02-28" version="1">MSSPFGEPPIGINLAENHTPRNNATVVCMFGLAAVAVALRVIARIRVQHSRIAADDYFIFVALLAVIATLVCTIMGTHGLGKHVWVVPLEDVIAIMKVLFAYVLAYVFTIPLIKMSIICFYRRIFGMNAAMWFCVFLTLGYCISCTVAFLSCCRPLSYFWTQYRDPNGGKCVFDLYRFYIGNAVANLITDVVILLVPIPVVWRLQMPTALKVMVSSIFILGGFVCIASLVRIYFMTFLNSSLDITWIMGDVFIWSSVEPCVGILCACLPTIRPLLRSAFRLLLGSLKAERTFGPCSSDDDVNELQSQYFQRPVSIGPCSPRSEEGEIILIKSITHVEVIGSFHDGTSDEDCDQDPLSIKVRKEFQWSVEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU85</accession>
    <name>A0A2I2FU85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_513436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699510.1">
        <property type="nucleotide sequence ID" value="XM_024855108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU85"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU85"/>
    <dbReference type="GeneID" id="36562814"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513436"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="217"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="395" mass="44079" checksum="A5E0EB935B1B50FC" modified="2018-02-28" version="1">MSTTTRSDSVPSTTNASSGKIVLSQGITRELSTSNAGNFTSIPVIDLRPLTSPTATATEKKRMVSEIRDACIKVGFFVIKNHGIDWNIVDAAFDALEEFFGLPLENKMKIHQSTSPSYMGYEEPYYTNIDGLSKGDSKESVYISYDPYLDPLGVGDAMPKILKRDNLWPDPQDAPKFRPAIEAYRASCLDLMRKMIRVLALAMGEEETFFDKKTTYPIATIRAIHYPPQEGSAQEEIGLGAHTDIQMMTMIAQRPYYAESLEVLNAAGQWVKPKLEPETFVVNLGDMVGRLTNDVFQSTVHRVCNTAPEGKVSQNRYSMPFFFGMNNDELVTTLPQFATEENPLNEQYLHGMTGYEHYNRRLQRAHHKHPSAINSASTALPPGMTKVNGILVSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUA1</accession>
    <name>A0A2I2FUA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_513400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699448.1">
        <property type="nucleotide sequence ID" value="XM_024855105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUA1"/>
    <dbReference type="GeneID" id="36562811"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513400"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="596" mass="67464" checksum="84864E7FB8453770" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUD7</accession>
    <name>A0A2I2FUD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_368028</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699561.1">
        <property type="nucleotide sequence ID" value="XM_024844837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUD7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUD7"/>
    <dbReference type="GeneID" id="36552537"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368028"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000243">
        <property type="entry name" value="Putative Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000095">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB44259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="576" mass="62569" checksum="6F62C76E9E19E204" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUE2</accession>
    <name>A0A2I2FUE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_440576</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699565.1">
        <property type="nucleotide sequence ID" value="XM_024850110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUE2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUE2"/>
    <dbReference type="GeneID" id="36557809"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440576"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000823">
        <property type="entry name" value="Cell cycle control protein (Cwf8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="18">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB44263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="476" mass="49687" checksum="4FE032ED72724B33" modified="2018-02-28" version="1">MLCAISGEAPQVPVVSPKSGSVFEKRLIEAYIAENGKDPVNGEELSTEDLIDVKSQRVVRPRPPTLTSIPSLLNVFQEEWDALALEAYTLRQTLSQTRQELSTALYQHDAAVRVVARLTKERDEARDALSKVTVGASRTAGAGDEAMQVDSTGLPEAVLARIESTQASLSKGRRKRPVPENWATSDSLSAYQPIANSEPLSTGGKALSVNATGDLALVGGTDGVVGVYSLSQKQVVHSLQANGPVTDAVWAGDKAVVAASTGAVKVFENGSEVANFSLHAGAATALAVHATGDIVASVGADKSYVLYDLSTNSVITQIFSDASLLSVKFHPDGHLIAAGGVDGQIKIFDVKTGAAAANYAMSSPVKCLFFSENGTFLAAVADKSTAVSIWDLRSSQEVKVLDTGNQIDSLSWDYTGQFLLTGGPSGLTVQQYSKSAKAWSEPLRSAVPAVAVGWGAAAQSIVALNGEGVITVLGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUJ7</accession>
    <name>A0A2I2FUJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_468029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699621.1">
        <property type="nucleotide sequence ID" value="XM_024852522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUJ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUJ7"/>
    <dbReference type="GeneID" id="36560220"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468029"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="120" mass="13082" checksum="B36B908D7CCB5E6A" modified="2018-02-28" version="1">MTGSQAQSSVGGGNLYVDGDQRTAPQSEQGRPAYKQGEPGSHSNLDSKDQRSIANKLASQERKPEPGNYKNGVYDPEAELSKKNPTQPAVNHGNEPSKGAQIDRELQLEDEQRLHEKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUP1</accession>
    <name>A0A2I2FUP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_440667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699667.1">
        <property type="nucleotide sequence ID" value="XM_024850132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUP1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUP1"/>
    <dbReference type="GeneID" id="36557831"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440667"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="193" mass="21475" checksum="A10EA07904BE0B1F" modified="2018-02-28" version="1">MDRHDHVSLLSSDPYETYQYSPDPNNSSPVDSSISSPPRRKRRRLSRLSAENHPPEFDHENHGETEPATSIDLTEPEGPSALSKTLAKQREDAIKAQQGAKNEGGRSLLTAYKCPVCMDTPVDATSTACGHLFCHKCIIDTLKFSEEQRADTSGKTPRGTCPVCRKPLTRNDVPGPRRNLIPLQLKLTTRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUV9</accession>
    <name>A0A2I2FUV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF924-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_480177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699714.1">
        <property type="nucleotide sequence ID" value="XM_024853760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUV9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUV9"/>
    <dbReference type="GeneID" id="36561458"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480177"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="19944" checksum="EE531EB93376524A" modified="2018-02-28" version="1">MSNYSYSDVLDIWFGPRSSPTYLQKKPFWYGTSASDDAYVRDNLGAPYQAAKEGKLDTWIQTGQGEGALALILLLDQVPRNMFRGTPQAYATDSKAIAVARQAVDSGWDKTMPTIQRRYIYSPLNHSESLEDQTFSLKLFTELGDSHHLRWAQDFYNQIKRDGRFIHRDQILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUZ2</accession>
    <name>A0A2I2FUZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_468142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699770.1">
        <property type="nucleotide sequence ID" value="XM_024852534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUZ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUZ2"/>
    <dbReference type="GeneID" id="36560232"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468142"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014189386" evidence="1">
        <location>
            <begin position="30"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="338" mass="38793" checksum="44BB85ACF615E108" modified="2018-02-28" version="1">MASNILATRLLSGILFALALLYFCQGSRAAPAPHEYSADEHFLLENATLPLHPREVHHAENTLHFLSKRVPPKTVEQGARMAESELLCHFGSDNAPPQMQFTEEHLRRWYSTGNYYGELDAPPDGISYTGHTLAKEMDALKLPTKLGDRGLQKFHWVQDQEFEFKGKLYEDGTDGFYKGVMSVERGFISAEDNDNPRQDVDDPYPPLYRMSDVYFLEWQRQAGQSNKVKKLRYFLRYHIVNPDTLAIIKEITDNYATLKEWPGTEFAIYKRVKGQVEGTDEGKALLRTPNGVAIAHFLLTNKRVMGKRIPDSVRLWKTQDGQNMWAHMIFHIVEYKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVD1</accession>
    <name>A0A2I2FVD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_289019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699902.1">
        <property type="nucleotide sequence ID" value="XM_024843231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVD1"/>
    <dbReference type="GeneID" id="36550931"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_289019"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="153" mass="17442" checksum="167CE03949468C01" modified="2018-02-28" version="1">MTTSDTDYRPTETLTRLNLFSRQSYLDNSYSDMSTWVGQRGSALVYCLLRRDSWEGILENTSILLIKTQESHPVDPPLMAGWRPRLVAFRLQRPAEAPLPRAPIGGRCPRLPTQEEVPWMVRSLRYGVRSMVQGENLVSDGDGRRGSHLTFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVQ0</accession>
    <name>A0A2I2FVQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_415394</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700021.1">
        <property type="nucleotide sequence ID" value="XM_024847062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVQ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVQ0"/>
    <dbReference type="GeneID" id="36554761"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415394"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="13">
        <location>
            <begin position="360"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="12">
        <location>
            <begin position="589"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB44719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="696" mass="78933" checksum="61D0E199C3DBB296" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWL7</accession>
    <name>A0A2I2FWL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_479495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700258.1">
        <property type="nucleotide sequence ID" value="XM_024853686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWL7"/>
    <dbReference type="GeneID" id="36561384"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479495"/>
    <dbReference type="OrthoDB" id="4496056at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014161565" evidence="1">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="113" mass="11964" checksum="5F7FFEEB992BA5ED" modified="2018-02-28" version="1">MLFALLSVALIASTMAVPLPEPEEASTPVMLAYDAKDAPEGATPVMLAYDTGSEKRSTPVMLAYDAKDAPEGATPVMLAYDAKSKKRSTPVMLAYDPKNVPENAIPAMLAYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX56</accession>
    <name>A0A2I2FX56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_479742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700523.1">
        <property type="nucleotide sequence ID" value="XM_024853712.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FX56"/>
    <dbReference type="GeneID" id="36561410"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479742"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002614">
        <property type="entry name" value="Origin recognition complex subunit Orc5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="568"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="591"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="663"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="700"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="736"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="772"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="808"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="844"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="903"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="956"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1359"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="961"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1378"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1528" mass="165697" checksum="47AA6859A6E8533E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXU0</accession>
    <name>A0A2I2FXU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_363795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700757.1">
        <property type="nucleotide sequence ID" value="XM_024844608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXU0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXU0"/>
    <dbReference type="GeneID" id="36552308"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363795"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="144"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="374" mass="42518" checksum="937096BA86952218" modified="2018-02-28" version="1">MSSSNPISPPDPQDILSIAQIVQPPQVPPHRSHDPANNLKRTDPFQFGSRYLEQGDNVYEFNAWDHVEPDDDFKAFAENQYAKQRESPVSDFDRARFNADPAKWWNLFYKNNTANFFKDRKWLRQEFPILADVTTAGAGRQVVLEVGAGAGNTAFPLLLNNANEELMIHACDFSKTAVQVMRDSEHYNTKFMTADVWDVSAVPDENQNGLPPGLTEGSVDVVILIFIFSALAPNQWEQAIRNVHRVLKPGGRVLFRDYGRGDLAQVRFKKGRYMGENFYIRGDGTRVYFFDKEQLRQMWGQWTPEKGLPEKIDEEAGATDSSAEPGAFEVQKLAVDNRLIVNRQQKLKMYRAWIQGHFLKKGDAAPEGDEKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYL4</accession>
    <name>A0A2I2FYL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701025.1">
        <property type="nucleotide sequence ID" value="XM_024849834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYL4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYL4"/>
    <dbReference type="GeneID" id="36557533"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439453"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="202" mass="22223" checksum="1B90D1DBDC8C48F9" modified="2018-02-28" version="1" fragment="single">MKPPGFSTTLPKTLHRISNKRLSMILSSNQGHIQHAKIRGHITLLKNYPCWQLNLSEQGTLRSLCESAITEVPPLGINPAIEDSNGKLKENCGQLDAGSQTTASGKILRPPPGLPMPAVPRMVAEELFSTANYAQTKTRLEEANAWFHKDPRGEKHLRQQVAAIAQNHAERIERLTGTDGTTAKQMSLLLGNVIVNLHSHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ58</accession>
    <name>A0A2I2FZ58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_364060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701225.1">
        <property type="nucleotide sequence ID" value="XM_024844624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ58"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ58"/>
    <dbReference type="GeneID" id="36552324"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364060"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF694">
        <property type="entry name" value="AMINO ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="472" mass="50718" checksum="5C8BFC391A756D0F" modified="2018-02-28" version="1">MATVSDEVKDVKIAAANPPADDIGIANSEEIKGGDDQYEVFKRGDGQVDFRTVSWIRASAIFLKMLFATGILSIPSVMYDLGAFPGAVNLVAWCLINAYGAIILGNFRNMYPQCHSVADMAHLIGGPILREIVGFMFIVTYVITASSGIIGVSAAFNALSLHAMCTVWWSVVATVIIAAFASVRKFSHIGWLTWVGFFSVLVAVFIIVIGVTTRDRPAVAPQTGDFDLGYRAIGHPTFAAGITAAATIFVSSSATSAFLPVISEMRNPKDYPKAVYLSMGFVTASYLSFALVIYRWCGKWIASPSLGSAGETVKRVAYGIALPGLIVSGSLYVHVAAKYLFVRILRNSRHLQSNSPTHWGTWLGCTIVLAAISFVLACAIPIFTYVLALVGSLCFAPLAISLPGLLWLYSHDHYRRGSVMRTVVYGLHCALVLLGAFMTVGGTYGVIVQIMDAYHSGKIDKVFSCADNSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Y8</accession>
    <name>A0A2I2G0Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_362176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701808.1">
        <property type="nucleotide sequence ID" value="XM_024844515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Y8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0Y8"/>
    <dbReference type="GeneID" id="36552215"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362176"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF2">
        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="523" mass="56999" checksum="A379D4AF9C81F31E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G164</accession>
    <name>A0A2I2G164_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Violaceus kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_411842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701926.1">
        <property type="nucleotide sequence ID" value="XM_024846912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G164"/>
    <dbReference type="STRING" id="1392250.A0A2I2G164"/>
    <dbReference type="GeneID" id="36554611"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411842"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014165630" evidence="1">
        <location>
            <begin position="26"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="342"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="981" mass="110026" checksum="20AFD745A91E4321" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1R8</accession>
    <name>A0A2I2G1R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Secretory pathway Sec39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_412133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702120.1">
        <property type="nucleotide sequence ID" value="XM_024846923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1R8"/>
    <dbReference type="GeneID" id="36554622"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_412133"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014182551" evidence="6">
        <location>
            <begin position="24"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Sec39" evidence="7">
        <location>
            <begin position="13"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="870"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="928" mass="102517" checksum="D3638173B8E3E011" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1X3</accession>
    <name>A0A2I2G1X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_438579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702176.1">
        <property type="nucleotide sequence ID" value="XM_024849632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1X3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1X3"/>
    <dbReference type="GeneID" id="36557331"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438579"/>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="266" mass="30354" checksum="6944C24F201CE3EE" modified="2018-02-28" version="1">MPRAWNLDKAAWLYPFRGLYYFASHRFLWPLFKTRLIPIVLLSTFIYFLLFFFTYLPQVAFLAIFQGKGAWVSGAFLVLGEGAAVVALLFEAFFVDETLVDIFDAVLVNEGYGELVTTSRVLYPQGDDVVQRLGKPTHSAVYAPFSLRQIIEFIVLLPLNFIPVAGTPMFLVLTGYRAGPFHHWRYFQLLDLSKPQRKDRIRRRQLQYTSFGTVALLLQLVPILSMFFLMSTAVGSALWAVDIENKRGLLVESGPDPVGDFHDNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2X9</accession>
    <name>A0A2I2G2X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_466536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702532.1">
        <property type="nucleotide sequence ID" value="XM_024852424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2X9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2X9"/>
    <dbReference type="GeneID" id="36560122"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466536"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="833" mass="92704" checksum="F585BFB45DDDAA61" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3E7</accession>
    <name>A0A2I2G3E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_478249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702702.1">
        <property type="nucleotide sequence ID" value="XM_024853543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3E7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3E7"/>
    <dbReference type="GeneID" id="36561241"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478249"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19844" checksum="ED61BC6837746A18" modified="2018-02-28" version="1">MTPPPQVRSGRGRSGGPLLSARVRSCPLVSARGRNASTTLQLAQYNGRIDQWNDKLALVTGATSGIGLEAALALYATSAHVFIAARDPRGKSAVKYIRPGIMATPYTTTADGVQRQFAVNQLAYFTLSAMLLPTVMASSSGDSNLRIVQISSASHRCSSIDLDINYENRPYDPYLSYGQSNTAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3K3</accession>
    <name>A0A2I2G3K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_193159</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702760.1">
        <property type="nucleotide sequence ID" value="XM_024842714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3K3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3K3"/>
    <dbReference type="GeneID" id="36550412"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_193159"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="114"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="569" mass="61527" checksum="A73C13B0B94A045C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G404</accession>
    <name>A0A2I2G404_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_194920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702891.1">
        <property type="nucleotide sequence ID" value="XM_024842729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G404"/>
    <dbReference type="GeneID" id="36550427"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_194920"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="104" mass="11421" checksum="9B2C7A20C15EA12D" modified="2018-02-28" version="1">MEDGKGTDEEQREMRKKEKRKRTEQEEKSSNKNNSLESISPAGSKRRNATRANSSLRSQGDPHLDDSTPPGTPRWGSAWDCPFGERSPGVQIPDSLDASVGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G442</accession>
    <name>A0A2I2G442_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic ring-opening dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_447578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702949.1">
        <property type="nucleotide sequence ID" value="XM_024850893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G442"/>
    <dbReference type="STRING" id="1392250.A0A2I2G442"/>
    <dbReference type="GeneID" id="36558592"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447578"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="11"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB47647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="285" mass="32308" checksum="E9E8678E50975C0F" modified="2018-02-28" version="1">MESQGKPTPVFLFAHGSTMMLGEESEPARIWEEVGNEALRRGIKRVVMMGAHWETLGDAVEVSMNPDPKKLPMGGVRNERYLPYKLAPDLDGGQRVLHMLQAAGFNARAAPRFDWIHDTFLIVIRMFPNCVPLPTTLVSMNARYDPHFHVKMGAALRPLRYEDTLIIGSGGSVHNLYRNHWEHMFRFSDNFAQPVAPAPWALQFRQAVEDAILRNRGPEVRRALSRLMKHPRFREAHGTDDHWMASLFVAGAAGALEDKGPNTMMGECWELVNMCNTQYQLGSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G459</accession>
    <name>A0A2I2G459_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-isomer-specific 2-hydroxyacid dehydrogenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_437439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702964.1">
        <property type="nucleotide sequence ID" value="XM_024849367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G459"/>
    <dbReference type="STRING" id="1392250.A0A2I2G459"/>
    <dbReference type="GeneID" id="36557066"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437439"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="37"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="119"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37133" checksum="C0B9A0EE20F5A23E" modified="2018-02-28" version="1" fragment="single">MKLAILDDYQSISRASFEPLRPRLTTISYYPDTLNPADPSQQDELIARLEPYDIIMTMRERTPFAASTLSRLPNLKLLLTTGARNLALDAEFAASRGVAVAGTLARPIGVHSTVQHTWALVLALARGVARDDAAVKRGEWQGNELGISLAGKTLGVLGLGKLGTGVVKIAKLAFGMDVIAWSTNLTQERADEVAREEGLEGGSIKVAGSKREFFETADVVSVHSVLSERSRGIVGPEELKAMKKTALLVNTSRGPLVDQDALLETLNRGGIRGVALDVFETEPLPKDSPWRTTRWGEDGRSQVLLTPHTGYLDEQIHGWYKEAAENLEKWLDGKELSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4D8</accession>
    <name>A0A2I2G4D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_456514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703043.1">
        <property type="nucleotide sequence ID" value="XM_024851632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4D8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4D8"/>
    <dbReference type="GeneID" id="36559331"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456514"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="359"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB47741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="536" mass="60867" checksum="FFDE3D90FFFB8E9D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4I9</accession>
    <name>A0A2I2G4I9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_427003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703093.1">
        <property type="nucleotide sequence ID" value="XM_024847752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4I9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4I9"/>
    <dbReference type="GeneID" id="36555451"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427003"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="423" mass="46396" checksum="38A4EFB981511300" modified="2018-02-28" version="1">MQQPKILIVGAGAFGLSTAYHLSLRGYKSVTVVNRFETPSKDSAATDLNKVLRTDYADPAFTKLAVEAMAAWKDPNSIFAGMYHESGWIMAANTMSTEAISDAYQRAEKAGLAGAVDYVTPQTMRKRWPAGAHWGFSRLEESVPSGKALMRMNEEATANGVISVSGPAGHIVKLVYGENGVCRDAIAADGTFHQANIVILASGANTATLVDVGEEVTAACSAVVVIKLEPHEIEKYRIPIIDNMEQGIIFPPDEDGFVEICSCRGITNYQNSILPRQSILHSVGNYPEDGCPKEIESELRTFVREMMPELAHRPFVSTELCWDAFAPDSSFRICPYPQAKNLFVATVGSGHAFKFLPTIRKNVVDMVEGNLDPELERLWAWKYGESARPKAHPYPSRDLGVLTGWKGRNAPASGKLPWTWSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4R0</accession>
    <name>A0A2I2G4R0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cl channel CLC-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_385827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703166.1">
        <property type="nucleotide sequence ID" value="XM_024845746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4R0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4R0"/>
    <dbReference type="GeneID" id="36553445"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385827"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="871" mass="95445" checksum="3428FA601746CC02" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5A6</accession>
    <name>A0A2I2G5A6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ribosomal protein MRP51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703363.1">
        <property type="nucleotide sequence ID" value="XM_024849442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5A6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5A6"/>
    <dbReference type="GeneID" id="36557141"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437770"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="50791" checksum="26B5E696A66C520E" modified="2018-02-28" version="1">MATTRLSPTANLLRKSRLFALPQALTPPDDPLAPKGRDSDTATLAHPIRASIVTPASSLARGDWGLKRPLPAKSTSQKSSRPVVRVNELDTFEHVTDFESAADHTVTLEKFQELHMPVSLPFKVNYATSIMPRHQSPFESHVDNTDTSKNLEEPGAKQFRHSGPWLAGQTRAQFDAYLKKVRGNKPELLQKLREKYVKKRTVERKKQAQDNGEDLATLEPVQVSDEEFQLYLKSLRGDPFALGPIIFELLDLPSPPAVPNDRIGQQYFQSPGTKLSSGEYAVSGPPKTHPSAGLSYMRSHALIYNHPSYGAQTYQRPVEARILRPKGKFKNKSAKAIAGVGGIAVEDLNAMTFIEQGSPPGLAAFDATIPGGGKYWVTPIRASVDSNGRIGLASYRASAAAKAPYRIEDYKKPGSISDVVRGNQRYVPRLDRSRPRTHRPRESAHGSTEDIAKNLMKTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5P5</accession>
    <name>A0A2I2G5P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_497382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703497.1">
        <property type="nucleotide sequence ID" value="XM_024854109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5P5"/>
    <dbReference type="GeneID" id="36561814"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_497382"/>
    <dbReference type="OrthoDB" id="10398102at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="212" mass="23981" checksum="FE8DD3DE25E5C1CE" modified="2018-02-28" version="1">MESIEWTDMAQERSAADEQMNNIGRGQGQGDANSKIPADDSFQKYNFANHSTQFLCAMCCKNLLPIIFQRKAINDDLFPILYCCCCCGRASNYGSFMPNIQADQIKEARDRHCRVAPSAPRDILSGYLVDHFAGDLVFLIKKSNLVTKSDYEATLQSILNHVHFDKLKVSVDQIRLLFNENERTLIYTIIDAWRIGLEHPQAAKRKGGTAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5Y8</accession>
    <name>A0A2I2G5Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acylethanolamine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_456842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703565.1">
        <property type="nucleotide sequence ID" value="XM_024851653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5Y8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5Y8"/>
    <dbReference type="GeneID" id="36559352"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456842"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="611" mass="65935" checksum="ECDBC62800006E36" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6B1</accession>
    <name>A0A2I2G6B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_477031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703717.1">
        <property type="nucleotide sequence ID" value="XM_024853408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6B1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6B1"/>
    <dbReference type="GeneID" id="36561106"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477031"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="222" mass="25350" checksum="D748F2A7F45CF6F5" modified="2018-02-28" version="1">MAYKSYKPELLMCQILQPDKFSDLTFTCRGRSYRVHKSMVFPQSPVIEAACSGLLQIANDDVVEMSGFDIETVETMIEYLYTSNYTVSLLQETSDASENNGGTKPAKSPIIQALIPHLKMFNIANHYQIDELKQKTRDKIQRTVTKESYYTMSFETARFTYKMTNDSEIRQSIARHIVASCSAFNYDHTWSELTKDALVIDVLRELTTGLIQAHADLSDWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6C1</accession>
    <name>A0A2I2G6C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_511025</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703727.1">
        <property type="nucleotide sequence ID" value="XM_024854841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6C1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6C1"/>
    <dbReference type="GeneID" id="36562547"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511025"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014182550" description="beta-glucosidase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="16">
        <location>
            <begin position="685"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB48425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="763" mass="82964" checksum="FB8945C772C4524A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6K0</accession>
    <name>A0A2I2G6K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_456972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703801.1">
        <property type="nucleotide sequence ID" value="XM_024851670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6K0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6K0"/>
    <dbReference type="GeneID" id="36559369"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456972"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="371" mass="42232" checksum="E4D68D00685CCEC8" modified="2018-02-28" version="1">MNYSFSGYELEHGVALRELASTAFNNLRTKVHHAHHCEKGKVQTRREWRHLPLHERIEFTDAVECLQALPTELSPKMQKAYPAVKSRYDEFVAVHIELSNNIHMSAEFFAWHRYFIHLFEQDLRDKCNYPGRLPYWEWGYDAFAPQNSSLFNGQPGSMGSNGEWIPNRGSQYWVSNHVDIPTGTGGGCVFAGPFVNYTVKMGPIDAPGVEPVADKFAYNPRCLSRDLNPTVMSTSVTFRNTTEHILEYDDVAWFQGVMQHDPRYPAEGLTYSLHGGGHIGVGLILGDVEASPSDPMFWLHHAQIDRVWAIWQGLSPHKRVYQISGTHTHTNEPPTANMTLDEMLDFGFIAEPVKFADLMHIRSGPFCYEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6L0</accession>
    <name>A0A2I2G6L0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_456975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703805.1">
        <property type="nucleotide sequence ID" value="XM_024851671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6L0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6L0"/>
    <dbReference type="GeneID" id="36559370"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456975"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03188">
        <property type="entry name" value="GST_C_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03057">
        <property type="entry name" value="GST_N_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="91"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="219" mass="24609" checksum="5F2B5C7CC093F6C8" modified="2018-02-28" version="1" fragment="single">MIKAPAVKLFYAPGSCSLAPHILLHETGIAFEGVRMRPGEARDAYPESFRQINPKMRVPAISLDGEVVTELPAVMTVISNLAPEKHFMGRSPLETARVYEWMNWLSGTLHSRGFGHYHRPDRFTDDTNGLEGVRSSAKRTILECFDDIEGRLHGLYAVGDHLTAVDPFLFVFYRWGVKQGIQDMKMYSQYSKLVSNLVRREAVAATLEAEDISSYIEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6N1</accession>
    <name>A0A2I2G6N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_465849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703837.1">
        <property type="nucleotide sequence ID" value="XM_024852361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6N1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6N1"/>
    <dbReference type="GeneID" id="36560059"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465849"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="150" mass="15303" checksum="E4094BBF5C7FC6C3" modified="2018-02-28" version="1">MQIITAVVRAFQLLFAIIVLGLSVALAKGQSVGSAPAITGYAAFTGGLGIVASLVGVAAFFISSLDGLISWAVDGLASLVFLAGGIAYAVILKDADCSDVSTTWDNQILSGGCVKVDGDKTCSFGGEDKLKSRCTSAKANTAFMLIDFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G730</accession>
    <name>A0A2I2G730_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_358216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703991.1">
        <property type="nucleotide sequence ID" value="XM_024844270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G730"/>
    <dbReference type="GeneID" id="36551970"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358216"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF168">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="31"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="217" mass="24353" checksum="06877B2120DE8D7A" modified="2018-02-28" version="1">MPSSTDFNRTGRVTVALTIFSVVLTTICVVLRFAARRIKHAQLGLDDWFAFMAEVTFWAFCADILVGVYTLGAGQVYPDPAEARRKYVQYLQSQYALVPPYILSVTLMKLSILCLYRRIFAVPTFCKKINFAMAICLLWFVASLTASLLNCCPIQYFWDKTVVGSCINFPVFFLATQLADSIIDLAVIGLPIPTILRLQLSMRKRLALVALFLLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7I8</accession>
    <name>A0A2I2G7I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704149.1">
        <property type="nucleotide sequence ID" value="XM_024853230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7I8"/>
    <dbReference type="GeneID" id="36560928"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475176"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="160" mass="18539" checksum="9C972044C89B2213" modified="2018-02-28" version="1">MVISVPVWNFGNLGRFNQSEIIHLKIQLILLQPCARTVKLFVACFIRLRWCHPAPAVGKNNKKNKAMWAKKSLLRKERAAEKKKQMSEKEREEEKKGEEKNAEMEKRRRWRSFTINVGTNMDGQWDVVPTLHLDAEASKKEADSLDGDFIINIDTEMTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G879</accession>
    <name>A0A2I2G879_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_358376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704383.1">
        <property type="nucleotide sequence ID" value="XM_024844286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G879"/>
    <dbReference type="GeneID" id="36551986"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358376"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="62" mass="7415" checksum="75F9BD6FBB7ADC05" modified="2018-02-28" version="1" fragment="single">EIIKKGIVLLDLVKLLIFKGPLNKFIIAKKVIPKVFMKKINYRLSFINKCLYYIFWKQLSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8J7</accession>
    <name>A0A2I2G8J7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_357817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704509.1">
        <property type="nucleotide sequence ID" value="XM_024844247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8J7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8J7"/>
    <dbReference type="GeneID" id="36551947"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357817"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="353" mass="38757" checksum="7035A8F25EB47321" modified="2018-02-28" version="1">MSESEKDTIPETFVSRKSKILAELSIPDAEYTDLSPKGSVDEGIRDLIRDINALPGLVTTSSCAGRISVFLEGRKSKPQPQQAPLGQNESFNEPQRQFVPSGGKGAGKWLFVSHEPLKEDAVPLGSVSGSESGRPEETKPTRSLCERFGLEPGDGKPPGMNQQGRAPRLVRFHFEPMILHIMTATLHHAHPVLSAASASGFRESGLQSLRCLDAEDGPSPIVAVRSAGLSLESVIGYCEEGDDDNEDLADSEPVIRSLVTEEYLQMLVAMSNERFSVNTERKERFRSSMLDLCAAAHSRGAKTKGKAKGSADWEDPEKRRERKKAEGLWRKKQLEEQKKKEEQEGAQGDVDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9C8</accession>
    <name>A0A2I2G9C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">CENPA homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Histone H3-like centromeric protein CSE4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_464893</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704781.1">
        <property type="nucleotide sequence ID" value="XM_024852285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9C8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9C8"/>
    <dbReference type="GeneID" id="36559983"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464893"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="18">
        <location>
            <begin position="78"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB49479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="178" mass="19526" checksum="D11BCBA693FBE582" modified="2018-02-28" version="1">MPPKTGRGRKISSAPREKTSAGRVEKESAAGPSKAAASPSTRGGRKSRGGKRPAASPRKSDVQPGDPTPQGRSRRYKPGTVALKEIRKYQRTYDLLIQKLPFARLVREVALELLPADVGSELRWQSHAIQALQEAAEAFLVHLFEDTNLCAIHAKRVTIMQKDIQLARRIRGVWGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Q2</accession>
    <name>A0A2I2G9Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_357769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704906.1">
        <property type="nucleotide sequence ID" value="XM_024844241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Q2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Q2"/>
    <dbReference type="GeneID" id="36551941"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357769"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="336" mass="37409" checksum="B7CAB32AEEFD5FB8" modified="2018-02-28" version="1">MVARLRPSAKYLNSPLGLQFTPTARSHARHFRSSTRGCGSSEQTRTYGHDPRLESLGKVIKDEYAVVRDSYDTPKHPIVLAHGLLGFDELRLAGPYLPGVQYWRGIKEALSMKGVQVITATVPPSGSIEMRAEELARDISVGARGKDVNIIAGLDSRHMISHLKPKDFNVKSLTTIATPHRGSSVADYVMKQIGDDRLAQLYYALGLMKVETGAFSQLTREYMEETFNPATPDVDDVRYFSYGASMQPSFWSVFRLSHRILEQIEGFNDGLVSVASSRWGGEAGYKGTLLDVSHLDLINWSNRLKWLAGEITGNRRRFNAIALYLDIADMLAKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9R5</accession>
    <name>A0A2I2G9R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_357589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704917.1">
        <property type="nucleotide sequence ID" value="XM_024844228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9R5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9R5"/>
    <dbReference type="GeneID" id="36551928"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357589"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="236" mass="26222" checksum="55E48AC46106C683" modified="2018-02-28" version="1">MSLSKDSSTPGAGSLHPSSSLDTSGTVPAPDGSRLYNIYHTVLHHHYDVTLADKTPLYHVENSLIRPKKPDLTVHGGMDESAPIVAVCKFLHFSRHLKVGLGDPQNISDVQWEDLVCMNYQLTKYRWQMTMRSPYGEVIKRSFVWKRTHSVGVEDSKPSILSSRNYKLVNEQTDRIVAVFTSNSLKSFTKCGKLQIHADYGREFELMVILTVLALYEKQRRRNNSGNGGGGGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA19</accession>
    <name>A0A2I2GA19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_447329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705028.1">
        <property type="nucleotide sequence ID" value="XM_024850865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA19"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA19"/>
    <dbReference type="GeneID" id="36558564"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447329"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF1">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="3">
        <location>
            <begin position="496"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="613" mass="68098" checksum="A502FB566196518E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA30</accession>
    <name>A0A2I2GA30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_357675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705030.1">
        <property type="nucleotide sequence ID" value="XM_024844234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA30"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA30"/>
    <dbReference type="GeneID" id="36551934"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357675"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="590" mass="65876" checksum="7C24EBF0C32DB598" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA37</accession>
    <name>A0A2I2GA37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705037.1">
        <property type="nucleotide sequence ID" value="XM_024853311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA37"/>
    <dbReference type="GeneID" id="36561009"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476022"/>
    <dbReference type="OrthoDB" id="4445019at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014151805" description="Hydrophobin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11953" checksum="94B92B71FFD53BBD" modified="2018-02-28" version="1">MKFTLFSLLAAASFVASQELPTCEAGTLKCCRDVVQYSELPSYVLEYYGIDPELNDANACSDGIDLVDEFDVARCNANGESLQCCGAFVSARPPLGDDSITLNCEDVFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA50</accession>
    <name>A0A2I2GA50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705052.1">
        <property type="nucleotide sequence ID" value="XM_024853313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA50"/>
    <dbReference type="GeneID" id="36561011"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476037"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="169" mass="19049" checksum="178E264764D64B39" modified="2018-02-28" version="1">MCCIESRRKWLTVRERSSRIYRNSRALETLPERQYKVFPSQNFRVLTNESPEESVGPRNIVGPHNKLVESVLSSAPSKVLDRATHFGIAPRTTALSNGRPTDHTIPDEPPSRAGLSRNGRISRFSAAHLCFNDIFVCPETWQASFGSAVDPWSLHLDVVLTRHPSRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA86</accession>
    <name>A0A2I2GA86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_426656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705092.1">
        <property type="nucleotide sequence ID" value="XM_024847725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA86"/>
    <dbReference type="GeneID" id="36555424"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426656"/>
    <dbReference type="OrthoDB" id="4427569at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="32485" checksum="8F02649D5F174F57" modified="2018-02-28" version="1">MSRRFIQTTEYIKYVSVYTGPGLFANLRDEYDEARKRLMKSEHAKIINDEDITSETCYVREVQLHSHLLFKVVVLDKNPPRELILRAAANTAWGILYARTPQCYSGYKMLRFHPSKEFSKQLRGDMRRISRIDFSHHHLFQMHVKPVTELRPSEWTPADVDAQYERYPLSCAEDAKFKEERQKRCKMLGYDTITFSRNSKGDTEILVQRCYEVLQCQMGPEIKVCAVDFVSSMKVHALSAKSFSNFMRISHNPNKLCASSIVVSYRNCPRNTQRMIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAI0</accession>
    <name>A0A2I2GAI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_355544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705179.1">
        <property type="nucleotide sequence ID" value="XM_024844094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAI0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAI0"/>
    <dbReference type="GeneID" id="36551794"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355544"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014160024" description="adenosine deaminase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="389"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB49877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="574" mass="64385" checksum="D3BF7ACAEB1C83B4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB53</accession>
    <name>A0A2I2GB53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_473675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705402.1">
        <property type="nucleotide sequence ID" value="XM_024853074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB53"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB53"/>
    <dbReference type="GeneID" id="36560772"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473675"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56535" checksum="A981E673B8C2B0E2" modified="2018-02-28" version="1">MSDSEANVPTRNARNRRKPRTVSSLTAQQIQHKRDLDRKAQRELRQRARSRVLDLEQDLARAKASSSERERSMMDEIQNLREENRRLRDCLESIGQFALNGLSTEESAQPMHERRSPDLVAMDDATHEPDNGPLQDDASTLSNGPVDIGPGTTGSTGNAVNNENTGAPGTTGTPITMAIPGNTRSTNHLGQDFTHNSHHQDAFRWSTNPQEESRQVLPDSYHDNTVSTGVELPSPDSESLAGQSIVDRPRQPDHYLDCTSHTQECIVAPSTTTVVTPASSIAANTLIQPPTSTTIASILPKHRSATCPLDQILLDFASSRRSLAAKGFPIDVVVGPSQPCLQAVVNRLSTGEVHATSRVLAEVLATFSHVALPEKLAFMFVMFRTMRWQLSSTDSNYDEMPRWLRPTAVQITVPHAAWIDNIPWPRVRDMLIENPEKYPFPVFSELYSENVTVNWPYDSMDTVSHQGDSLIFNPIFEKHVRKLDNWTVSGHFRDYLPEMTAAIYGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBA2</accession>
    <name>A0A2I2GBA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dbl homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_454737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705429.1">
        <property type="nucleotide sequence ID" value="XM_024851471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBA2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBA2"/>
    <dbReference type="GeneID" id="36559170"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454737"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="158"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="805" mass="91015" checksum="DA2BCBDEAF77A66D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBI9</accession>
    <name>A0A2I2GBI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_380747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705545.1">
        <property type="nucleotide sequence ID" value="XM_024845543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBI9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBI9"/>
    <dbReference type="GeneID" id="36553242"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_380747"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048674">
        <property type="entry name" value="COQ9_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21392">
        <property type="entry name" value="COQ9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Ubiquinone biosynthesis protein COQ9 HTH" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="COQ9 C-terminal" evidence="10">
        <location>
            <begin position="200"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="300" mass="32798" checksum="3076D736E8C88E5D" modified="2018-02-28" version="1">MAHPTLLSRSPSFLAPSRRCLFSLPASSSVAASQSRRLHRLSTTTTTSKSLQTNSPRLSNRLIPSNYSPSPRSYHSQHHPDPPVHEYTNSQTTILSAALRHIPQHGFTRDALTLGARDAGFLDVSVQLFPRAEFDLILFWLASRRGLLRASVDDGLLLPYADASVDQKIKVLLMERLRMNVDIRHQWQDALALMSLPSNVPLSLSELHALSDDVLNLAGDSSVDAAWYTKRLSVSAIFASAEVVMTREAPGSGLADTEAFVDRRVEDVKALGDKVSGVKQCLGFMGSTAVGLGRSWGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBU2</accession>
    <name>A0A2I2GBU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_435551</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705656.1">
        <property type="nucleotide sequence ID" value="XM_024848964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBU2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBU2"/>
    <dbReference type="GeneID" id="36556663"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435551"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="74"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB50354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="499" mass="56839" checksum="B9A8CEA48CADB935" modified="2018-02-28" version="1">MDQHDDFDSVSWRHDAGSDVSGSRPTTSGTDAEESPGLHHDVNGKRRMSSAGHEPPQAGPLADAVDLAGIADGVLECQVDSPLKENDGTKDAYISYLVTTHTDFKSFQKPEFTVRRRFTDFFFLYKTLYREFPACAVPPLPDKHKMEYVRGDRFGPEFTTRRAWSLHRFLKRLTLHPVLRRSALLAVFLESPDWNAHMRLRSTRNSTSTSDGSGVPGIFDNFTDTFVNAFTKVHKPDRRFIEVREKADKLDEDLNHVEKIVARVARREADLEADYNELATQFRKLVPLEPDVEVPLQVFAASVEETGRGLKTLKDHTDQNYLGSLRDMEAYILSVKALLKTREQKQLDFEALVEYRNKAVAERDSLATNPSSYYASNPLTSSPASFIRSKMEDMRGVDHEQSRRERVRKLELRIDELTREVESAKTTSEMFDEEVVREVADFERIKAVEFRDTLGALAEKQIEFYQGVLNTWERFVAEMDGDFEEGLASQAQEGAAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCC7</accession>
    <name>A0A2I2GCC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_435726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705834.1">
        <property type="nucleotide sequence ID" value="XM_024849006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCC7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCC7"/>
    <dbReference type="GeneID" id="36556705"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435726"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="389" mass="43362" checksum="3E5A0D8137EF26E3" modified="2018-02-28" version="1">MALDNYYRNKIEGMKLEIIQGQAVLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMSTKKVLVKVHPEGKYVVDIADGVDIGKLTVGKRVALLSDSYKLEKMLPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCRFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIDSAGSGDSEVQRTMLELLNQLDGFEPTKNIKIVMATNRLDILDPALLRPGRIDRKIEFPPPSVEARADILRIHSRSMNLTRGINLTKIAEKMNGCSGAELKGVCTEAGMYALRERRVHVTQEDFDLATAKILNKHDDKEVAVSKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCG5</accession>
    <name>A0A2I2GCG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_148225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705862.1">
        <property type="nucleotide sequence ID" value="XM_024842504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCG5"/>
    <dbReference type="GeneID" id="36550201"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_148225"/>
    <dbReference type="OrthoDB" id="3557758at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="272" mass="30633" checksum="68390A7C9E71AA43" modified="2018-02-28" version="1">MMEKQGRQSSIVNSLQSLKSTLGDKGSRRKKPLGSTSNFIASRIPTPSKPPQGDMYSHGVYRQEGRRSVLSSLGQRYLNRRKSGKEYRPVDQFRAEREGGRPCEVLAPSPRPASIARQPPVMNALPASVTVPRMPENCRSPAPSRVFKAFARPKETIRGSRMASCFRRSAPAGPVLEVTEPQPRQYWLGRLVTLTNAFHYEDSFHQPDIATGFGMLSSYSRPLGRSDADLSDYRTKRAFMVLENVCTTDQASASLRAFREEYVRFHGDCWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCY7</accession>
    <name>A0A2I2GCY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_435926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706045.1">
        <property type="nucleotide sequence ID" value="XM_024849051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCY7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCY7"/>
    <dbReference type="GeneID" id="36556750"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435926"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000190">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="191"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="415" mass="45342" checksum="E2F7FB6CC5800CB0" modified="2018-02-28" version="1">MASQKITSALADIEASANPQNKLQLYSDLLSDVVSTSSADQLAQDLIFYLDSVLSEDISIVAARPILDSFIAVLRKLDPETQIKVGQHAVTLLQSRSTSVEEQDSQIRELLADAYESQEEYIAAARALQGIHIDSSQRLVSDAAKVRLWVRIVRLYLEEDDTTTAEAFLNRIKNLPSKIEDHELKLHFKLSQARILDARRKFLDASQEYFNVSLAAGVDESDRLQALAAAIRCAVLGPAGPQRSRILATLYKDDRATSVEEFGILEKMFLDRLLNPAEVAAFSERLAPHQLAQTADGTTVLDKAVVEHNLVAASKLYENITTDALGAILGLEGSGDLTAGEKAEAYAARMVEQGRLSGSIDQIDGVIHFQSSTAATRQHIRQWDAGVQGLAEDVERVATSITDAFPEFAAGQTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD02</accession>
    <name>A0A2I2GD02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_474315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706061.1">
        <property type="nucleotide sequence ID" value="XM_024853120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD02"/>
    <dbReference type="GeneID" id="36560818"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474315"/>
    <dbReference type="OrthoDB" id="4507141at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014160025" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="74" mass="7974" checksum="D92AA7FAC1BEF7F7" modified="2018-02-28" version="1">MQFFQTLLPIALLASLGAARPADSVVRDSEVFARDSLKSCIGKLQTQSQCTNVTTSPFACCPPMTCGSDKLCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD87</accession>
    <name>A0A2I2GD87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_155155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706145.1">
        <property type="nucleotide sequence ID" value="XM_024842538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD87"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD87"/>
    <dbReference type="GeneID" id="36550235"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_155155"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="79"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="220" mass="25015" checksum="5921DF0CFAFABB1F" modified="2018-02-28" version="1">MDSIAEALGKLCVRIVYGPDANIPKSITRRRKENAPKSLPHKRARSLSISDDNKQGPLLIKIQTQDKKIFKKQQYFSLQTQSGLLAFLPPEIRVQIWRYVIASFDLHIVRAAKTLWAIECAGEGMAQRPLCFHDCWGVSDRPFAGYHGTTPGYCYSTRGYAKFRDGISLLQTCRLVQHSVPRKYISLQSCEYMERDLPIAGEHFGPKRAVHPPRRMEPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDE3</accession>
    <name>A0A2I2GDE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_311745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706139.1">
        <property type="nucleotide sequence ID" value="XM_024843251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDE3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDE3"/>
    <dbReference type="GeneID" id="36550951"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_311745"/>
    <dbReference type="OrthoDB" id="4525788at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="297" mass="33675" checksum="77C0FE902D4CBC13" modified="2018-02-28" version="1" fragment="single">SSVPLIPPPETINDAHKVYSIAVACIVLGVVSSLCVLVRLGQRIHAHAFGSDDCAIIPGLLFYIGWTAMAAYVNLHAGVGKPLWENTLGEFSVWFKGIIGSGWLYPAMSMSIRTSILLLYNRMFSKAMPRLRYFIWALLVLQVVYLIVFSILPAFISRPLYKAWNPLERQKYVNDWYYYYTQVALYSTSMAFDYILLVLPLYPIAKAQMSLRKRLGVSVIFILGASAGIAATYKLAIFVQQMTRYTKIDPRWMQYEMSLRIPPQFDEYGTTFWIPSQVEPSVALIGTSLPAIRQLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDR1</accession>
    <name>A0A2I2GDR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_436118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706336.1">
        <property type="nucleotide sequence ID" value="XM_024849088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDR1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDR1"/>
    <dbReference type="GeneID" id="36556787"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436118"/>
    <dbReference type="OrthoDB" id="4207132at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="283" mass="31888" checksum="CF10C6EC583B1BC7" modified="2018-02-28" version="1">MSPATYFPEKLWLSKSITFSSPSSPSSSTWIITRKINEKAYPFDEEDAKEFLEPPSACATFECTNSESALQKGVMQVDMQIPYEGTEYLPESDRVKQATGKFSLGMSLEIRAYELLDQTSSKYTPRLRGHMQAKQASDSAFVPEGSIQYLVYTAVPGIPLGDGCCHRRKDGRNQSDGPYWEFSSEEREEIRTAFHDAYREMLFAGVDMPSQGLQNLYWDEGDRRLYIYGPFEPMNTGIRGYSSHTPTDFGPLVLRSWGLAIAPRGKVDYDVAIADLENSGWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEJ4</accession>
    <name>A0A2I2GEJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polymerase nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_474835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706592.1">
        <property type="nucleotide sequence ID" value="XM_024853183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEJ4"/>
    <dbReference type="GeneID" id="36560881"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474835"/>
    <dbReference type="OrthoDB" id="5421247at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25081" checksum="66D3067A9AC2B1D5" modified="2018-02-28" version="1">MADYPQLHEQRRAVRRVIRHLKHIIRLQSDGRFKCHDRLKEIPSLHSLKLVAIGGFAVRSLLPVPRPTMDVDLMVDLYPTGDELPKLPNGLAQALKALLIFQYPEIYSQDGDYFRVKIQSTPALRIRVDFVLSALLPFVPRAAHHVLTIPTNHIPLSSISDLLAQKVYCCSLRPWLDKSFQDVADAERLATHLGPLVYGCQSAWLVVVKISFVFILLLVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF89</accession>
    <name>A0A2I2GF89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_443747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706855.1">
        <property type="nucleotide sequence ID" value="XM_024850579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF89"/>
    <dbReference type="GeneID" id="36558278"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443747"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="241" mass="26619" checksum="769B0068B3782976" modified="2018-02-28" version="1">MKFLCLPGGYCNRKVRPLSQCLNASEKADFHFTQGDLAVKIPLVEFEGFFGPPPNYTFVDVNLGTTAFSIREFPKRETPEETMRLVVNMLNDPRPSNIPEVMDRLIGILDSEGDIDGVIGYSEGAVMATTLLLEEARRQRDSGRQPMIKCAVLICGWPPMDPVTGQTMLTDQFDEVIDIPSCHVVGGQDPFLDASMALYNFWDPDQAHIFDHGGGHAVPRELGTCQEIAEIIRGLISGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFC2</accession>
    <name>A0A2I2GFC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_376130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706882.1">
        <property type="nucleotide sequence ID" value="XM_024845350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFC2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFC2"/>
    <dbReference type="GeneID" id="36553050"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376130"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="27175" checksum="AB7965BEEB1C3AFD" modified="2018-02-28" version="1">MAAVAENPPLPVNENTAPTPATEQTEKPNGDSVTVFHDADNFNVKHPLMHDWTLWFTKPPSGKGDNWNDLLKEVVTFNSVEEFWGIYNNITPTSELGLKADYHLFKKGIRPEWEDPQNKHGGKWSYSFKDKRSVPIDELWLHAQLAAIGETLENDGDSEVMGVVVNVRKGFYRVGLWTRTVGKSLPGDKAGTRTPAQGKEVLESIGRRFKEVLRLKESDVVEFSGHTDSAHSGSTRAKAKYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFN6</accession>
    <name>A0A2I2GFN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_83508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706996.1">
        <property type="nucleotide sequence ID" value="XM_024855407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFN6"/>
    <dbReference type="GeneID" id="36563114"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_83508"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="158" mass="18065" checksum="5A27B1C2BE35AAF6" modified="2018-02-28" version="1">MAGGKEQVHHAASHIESSQRPRIGCETRLRRRLPLRFIASNWRLRVHCQADLSRLEKVRAYNVNTRVSRSSTTCCIGFFFVGHPAAPFFICPFLGETRLFTLCMYGCIRRKRFSGLSWEAGGSVAQRRDYIMGSTIRMSLCSGEYEKRFMTHATLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFX1</accession>
    <name>A0A2I2GFX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_433634</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707062.1">
        <property type="nucleotide sequence ID" value="XM_024848542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFX1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFX1"/>
    <dbReference type="GeneID" id="36556241"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433634"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="152"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="467" mass="50826" checksum="99FB87A6089A718D" modified="2018-02-28" version="1">MASRLPLPRLPEQRLRAIPRVAHGSRYLSTAGRRNFASAALCRHLSRPSGSSTSPLQVPVSGAPRFDLGFFGRHQVRTYADSIVKVPQMAESITEGTLKQFSKQVGDYVERDEEIATIETDKIDVSVNAPDSGTIKELLVNEEDTVTVGQDLAKLELGGAPEAKKDESSEKPKEPAAEKPKAPTEPAEETKPSQKPASSEKPAAPEPQSNKKPAPEASQSQASDTAKSTPSGREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSSLMDFRKLYKDDVLKKSGVKLGFMSAFSRACVLAMRDVPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNAEAMDLVGIEKAIADLGKKARDNKLTIEDMAGGSFTISNGGVFGSLMGTPIINLPQTAVLGLHAIKDKPVVVNGKIEIRPMMYLALTYDHRLLDGREAVTFLVKIKEYIEDPRRMLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGL9</accession>
    <name>A0A2I2GGL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_422926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707312.1">
        <property type="nucleotide sequence ID" value="XM_024847472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGL9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGL9"/>
    <dbReference type="GeneID" id="36555171"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422926"/>
    <dbReference type="OrthoDB" id="4525788at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="325" mass="36016" checksum="51D06EE77D941901" modified="2018-02-28" version="1">MPPPMVTTVRAVVATVAILALMVCCTRLYLRKFITRAFGLDDCLVILALILVLLFAALSIYLTFFGIGRHMDTVPDEQLATMQYAIYISLCTYLFVASAVKISLLVFIMRAFPTRLIRWLGLGIVGFLVLLTISGELPLILQCSPVRAAYDKTAPNYKCFSSDTLFDIEMYQGVLMFAVDLAIFVLPIPTIWKLQMPLQRRLTVIGLFGLGLVACVAGLARLPTLVYQKDDTDFTYSGATPLIWMNVEFGLALITGSLPSTRILLRKIPGFSSYRSEGKELSEGHGNGQSGYHVGQKRWTSKMLGKGRDDIESVASESEKRIFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHV8</accession>
    <name>A0A2I2GHV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_312795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707768.1">
        <property type="nucleotide sequence ID" value="XM_024843261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHV8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHV8"/>
    <dbReference type="GeneID" id="36550961"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_312795"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="84"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="216" mass="24243" checksum="E895C6671B101D35" modified="2018-02-28" version="1" fragment="single">MPFGTIYSFPGDQPRTIAIKAVAKANNLDLKIVEEPKTPAHFAVSKLGKVPAFVGEDGFELIECIAIAIYITSQNEETTLLGKTKKDYANILKWMSFFNSEIIVPLVEKYLPLVGIRPYNKDTVDMFTNMAQAAVDVVEEHLTGKTFLVGEEISLADLFCAGIISFGFVFFYGKEWRQANPNVSRWFEHIINQPIYSAVTEKVEFLDEPKLTNVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI40</accession>
    <name>A0A2I2GI40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_402809</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707848.1">
        <property type="nucleotide sequence ID" value="XM_024846446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI40"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI40"/>
    <dbReference type="GeneID" id="36554145"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402809"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="159"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="368"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB52546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="587" mass="65546" checksum="73C495D46456C0AD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIB0</accession>
    <name>A0A2I2GIB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_472507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707920.1">
        <property type="nucleotide sequence ID" value="XM_024852951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIB0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIB0"/>
    <dbReference type="GeneID" id="36560649"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472507"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="416" mass="45857" checksum="A4AE57DACB5E4FA7" modified="2018-02-28" version="1">MAPPKVFSLEGKGLKLDTAEDVEAHIKPLLESTDYTEIRLGGNTFGVTACERFAAAFSTQKTLEVAELADIFTSRLIEEIPDALTHLLNALLAIPSLHTVNLSDNAFGKRTSKPLVDFLSRHVPLRHLILNNNGMGPDAGAEIADALKELAQRKEEARKAGKEVAPLESIVCGRNRLENGSMAAWARAYEVHAAGMRSVKMTQNGIRQEGISLLIREGLRHASGLEVLDLQDNTFTIMGSTALAEVLPGWPALRELGVGDCLLSPRGGVKVAQALAAAKNEKLEILRLQYNDITAEGVKQFLHATKTALPSLRRIELNGNKFMEEDDNITELREILESRQEEHGKDDDPEDMWGVDELDELEEESDEEEEEEEEEEEEHKAEKVVEDATRAENEKVAQKQDKEVDELAAALGKTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIB1</accession>
    <name>A0A2I2GIB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectinesterase</fullName>
            <ecNumber evidence="5">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_462508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707918.1">
        <property type="nucleotide sequence ID" value="XM_024852106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIB1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIB1"/>
    <dbReference type="GeneID" id="36559804"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462508"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000045">
        <property type="entry name" value="Pectin methylesterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014189404" description="pectinesterase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="11">
        <location>
            <begin position="163"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="390" mass="42210" checksum="ABD9FA0452A46E4B" modified="2018-02-28" version="1">MKLSTLSTFLFSAAGVYSAAVPSNARHACQKSLKSCAPGTIVVSQSSHPSAQFSTVQAAIESLPDDNSTQTILILPGEYKEQVNVTRSGPITLLGQTNNPKDATKNKVTLTWAQSNHDNTGQAEDNVFSGVLTVAPTLESSYTGSGPTGYPVPEDTPFGNVDFRAYNIDFTNTWSDYSDGPAHALSFSRANGGFYYCGFYSYQDTVYVGKLGNAYFHKSIIAGQTDFLYGFGTAWIQSSQLLLRNCGGGITAWKGTNTSFVNNYGVYIVDSSVKAANSSIAPTIKGKCALGRPWNSLHRSIFANTYEDESILPAGYIDWVVDGQSRLTSQTFMAEYKAFGPGFSDSGRDSTNASIVLDGRAYKRYDSLKKVFQTPEGKFGNVGWIDRNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIK6</accession>
    <name>A0A2I2GIK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_507462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708016.1">
        <property type="nucleotide sequence ID" value="XM_024854487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIK6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIK6"/>
    <dbReference type="GeneID" id="36562193"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507462"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="424" mass="48084" checksum="16BA37B73A88D380" modified="2018-02-28" version="1">MDPLSAELILQIVQGDLQDTLRQRQNSSQNGELRNFPSDQELALREWEAQLQQYLATLIDHQMAHSISNAVQDDGVAVTIAIEEERRALADRVTALRVEGHDVPNPEQLMVQENAAMAGLVGNPPTIVDAQGSFLDPGTSSSDCQLQEPAENWRRLPCASCAAVFPSPQLMEAPCGHIYCRGCATHLIEHSFVDESLFPPRCCRLAFPVSAVRQILGLDIANRYDEKSIERNDPYRTYCSNPQCAQYIFPAQVAFYVGTCNTCAQKTCTLCKKAEHPQCPCPAEDSEVLVLAEQEGWRRCPGCRNLVELKDGCNHITCRCRFEFCYICGTPWRRCRCELWDEERLVHRAQVLVGRDQPGPPPQAEVQRVARYLRQRESCDHEDDWTRLDGVYECEHCLEELPYFILLCPLCGIRACVRCKYNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIN3</accession>
    <name>A0A2I2GIN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_434462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708044.1">
        <property type="nucleotide sequence ID" value="XM_024848722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIN3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIN3"/>
    <dbReference type="GeneID" id="36556421"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434462"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="293" mass="31785" checksum="35DA281CDE1739BE" modified="2018-02-28" version="1">MSTLSSPRPSIASSRAHSPTPASSRRPSLDALNTHVGSGGGLSASSTPSTARAVSPSLRPRRNRSALRDYYNLKPSAADPSGGPRSPSVPRHTDAGDISNPSVLSTGTELDSPDFDPQRYVNHLLATSSLSTILKAENTLVGDIRTLDSERKALVYDNYSKLIRAVETIGKMRRSMDDRGAPLTMTKTLGPAIAFVAETAGGLIQEGEEQRRRMKEAKMSDAADRKKSERQTVKWVLGAPERLEKLLADGSKDEAERDWEEVRTLLAKWGEVKGVAEVRESCEKVMAKKDEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJE0</accession>
    <name>A0A2I2GJE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_454207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708303.1">
        <property type="nucleotide sequence ID" value="XM_024851411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJE0"/>
    <dbReference type="GeneID" id="36559110"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454207"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106006">
        <property type="term" value="F:cytoskeletal protein-membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000045">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000164">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="13"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="875"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="670"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="935" mass="102667" checksum="32BBB317B9A7FCEF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJE4</accession>
    <name>A0A2I2GJE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_434716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708297.1">
        <property type="nucleotide sequence ID" value="XM_024848777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJE4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJE4"/>
    <dbReference type="GeneID" id="36556476"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434716"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="124"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="420" mass="45902" checksum="1316FF87A1DCA48A" modified="2018-02-28" version="1">MRTRSTAPAAQPAPESEPEQLPPPPPTAERPSKTFILPSAATDDARLVRLPNPRTGELTRYFFCPKLGIHEFTAVAAPSHAPRSILFSHKPENSTGGKDNGAPASGSISKAAQLLVATPVDAMFFMIPILSPPGTSKGLFQPLDDILDSQDELPKHMRHVLFNQTFESTLQARAEAVCDSVEAGDQKMFRFNETKLLGELIAKAERMAAQGLPKSLEERFVRQALATPLMAVKRENPTTKEASSENKENEGEEDSEAKETPSTTTNSNSVSDGSTPATEPLPEEPTTSANVTHLLRISTALAFMKESYLSTAICARIDELLASPDSPIDFKPLNDHLKHIADLRAEALASRSLGDFSRKRNAEDDDAAEVRAEKKRRKEEEEKKKKAGESRGVKDLKKVNTTGMKKMSDFFTKAAPKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJU9</accession>
    <name>A0A2I2GJU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_444970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708458.1">
        <property type="nucleotide sequence ID" value="XM_024850669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJU9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJU9"/>
    <dbReference type="GeneID" id="36558368"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444970"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="186" mass="20279" checksum="45149DE1C627EDCB" modified="2018-02-28" version="1">MSSATSFYDFEPVDKKGSPYPLTSLKGKVVLVVNTASKCGFTPQFQGLEALYQNLKGKYPDDFLIIGFPCNQFGGQDPGSNDDIQSFCQLNYGVTFPVLGKLDVNGDSAAPVWTWMKEQQPGVLGLKRVKWNFEKFLISADGKVVGRWASLTKPESLEDTIVKEIEKAKKEGTLASAGAGEQAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKT6</accession>
    <name>A0A2I2GKT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-4-keto-6-deoxy-glucose-3,5-epimerase/ UDP-4-keto-rhamnose-4-keto-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_473318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708761.1">
        <property type="nucleotide sequence ID" value="XM_024853024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKT6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKT6"/>
    <dbReference type="GeneID" id="36560722"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473318"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="295" mass="33099" checksum="437248D231D5BD2C" modified="2018-02-28" version="1">MVSVTASPPVFLMFGNGWIANQLKDVLVSQGKTIIMSQARTESREQVLSELIKHKPSRVINCAGTRGTPNVDWCEEHKVETVRSNILGTLNVVDVCHGFGIHVTQIGSACIYTLSEEEIDNHPPFKETDEPFFQGSWYARSRLLSELSIRHYPNLLLLRIRLPIAADMHRNNHLSRLLGFEKIVDRTGSGTVLPDLLPGAVILSENAETGIYNFVTPGEISNVELMELAKKYIRPNLAWKTFGLDDMLAILKAPRANCIMDATKLQNKLREYGFEVKERREALEGVFQTLAQKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKW9</accession>
    <name>A0A2I2GKW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_424237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708809.1">
        <property type="nucleotide sequence ID" value="XM_024847556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKW9"/>
    <dbReference type="GeneID" id="36555255"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424237"/>
    <dbReference type="OrthoDB" id="4401278at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="224" mass="24898" checksum="B37EEF5A0DB4DA31" modified="2018-02-28" version="1">METPGDLEYANFKPTPTDLERRAILESHGFEFEPAQPFIASLYGYIHDAVLSAGIEETCKELSQQVFLASLSRDAMIPPPVQDTHMYHRVKVSFNIATATLGQKAQEADVRVVFTAMMWHLGTPNDLVAVRDTYEKRGKCRGQKVVVLKLKVIHDGTKARASCWVALDCGQDVDFEAAGVFDPKPDYSSDDVAGSWFAGMLWSPTAISNVLVLLILEVYVVFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKX2</accession>
    <name>A0A2I2GKX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_435132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708826.1">
        <property type="nucleotide sequence ID" value="XM_024848866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKX2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKX2"/>
    <dbReference type="GeneID" id="36556565"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435132"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="633" mass="70734" checksum="ABC94B9D62B860FF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL21</accession>
    <name>A0A2I2GL21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_435172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708876.1">
        <property type="nucleotide sequence ID" value="XM_024848879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL21"/>
    <dbReference type="GeneID" id="36556578"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435172"/>
    <dbReference type="OrthoDB" id="3542212at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23785" checksum="94835E382381BC58" modified="2018-02-28" version="1">MAITELALVRLKSPDDSTTRAGMLAAIEAQAAYSTFPVYLLTQIEDPSYVYIVGGWASTATHMQDWIASEINQKVLTALQDHVEVCWMMHVDIDPGEPDGRLPLDAPVLAIGRHFIADGRKEDFGRTFDATKSHLQRFAAPHGVRGGWRIEPQETTAEGVTKEEFVLFSGWTEVAQHDGFAETAGFQEFARIKEWLEGAEIKHARVWERSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLE6</accession>
    <name>A0A2I2GLE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_441983</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709007.1">
        <property type="nucleotide sequence ID" value="XM_024850429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLE6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLE6"/>
    <dbReference type="GeneID" id="36558128"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441983"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="223"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB53705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="416" mass="45972" checksum="D43F5215C5B1E141" modified="2018-02-28" version="1">MASETWAGVCVHCADLLANVPVHILLLTVVATLIGAFVLSYVILCIVAPVPRSPLPGEKRYRTLSKEGSITEPQQLPCWYDTLTARTRRMPDHAAMETPELFMSLVVPAYNEEDRLGGMLEEAVNYLERMYGTLASHAEEEVPALRERMTRRRTAAKEHLNGQAANGPARANRGWEIILVSDGSKDRTEEIAFNFARDHQLSLHPKGHAGPWTPKVQEGVHIPPGTIRVVTLAQNRGKGGAVTHGMRHVRGQYVVFADADGASKFEDLGKLVTACQEVEDSEGRGVAVGSRAHMVGSEAVVKRSKLRNFLMHSFHLILWLLTPSKTATIKDTQCGFKLFSRSALPYIIPYMHSEGWIFDVEMLMLAEFAGVSVAEVPVGWREVKGSKLNVLRDSIGMAWGLAVLRAAWSLGVYRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLV8</accession>
    <name>A0A2I2GLV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_420654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709155.1">
        <property type="nucleotide sequence ID" value="XM_024847311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLV8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLV8"/>
    <dbReference type="GeneID" id="36555010"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420654"/>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="137" mass="14871" checksum="C91B3970D21CBA80" modified="2018-02-28" version="1">MAQSPSEKLLLGADMAKRFLGEELLSRLSVNASQKDDIFTKTSQEYIAEVCFSSYARPGLKFRERALMNIAMLTALNRGPELRIHVAAALHNGITEEEISEACRHAMVYCGVPAGRDALAVASEVVSSVKGVSESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMF8</accession>
    <name>A0A2I2GMF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TrkA-N domain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_397065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709356.1">
        <property type="nucleotide sequence ID" value="XM_024846156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMF8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMF8"/>
    <dbReference type="GeneID" id="36553855"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397065"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="219" mass="24093" checksum="A91E68A80437F8A3" modified="2018-02-28" version="1">MRVLVIGGSGRTGKLTITELINRGHQTTTLARNPSAMDNLSGLNVIKGTPTELADVRSAFNHAIPDAVIVTLNAPRATDSPFAAPVSDPRLMTICNENVATAMKEYGVRKVVILQAFGVAESWSNMPCLLRLLMSKSNMIYQYNDHNETDRLIRASGLTYVFVRPSRLVETDEEKVTVWPNHGKGVSMMASTSRVSVARWLVDAMETDKWDCMAPVITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNM3</accession>
    <name>A0A2I2GNM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative hydrolases or acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_432100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709761.1">
        <property type="nucleotide sequence ID" value="XM_024848188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNM3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNM3"/>
    <dbReference type="GeneID" id="36555887"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432100"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="410" mass="45655" checksum="C4C346EBC59A4958" modified="2018-02-28" version="1">MAKAFEIAVPDAQLHRLQQKLETASFPDELDDAEWSRGVPLAEMKRLATYWRDGFNWRQKELELNQTLKQFMVPITVPGFGELDIHCLHHTSPNPNAIPLLFIHGWPGSFLEATKLIPLLTAGNGQPAFHLVVPSLPNFGFSSAVKQKGFGLVQYAEAMHAVMAALGYYDYAIQGGDWGSIIARIMAHRYPDHAKAVHINCLPVMPPLPWRNPLLFLQSLLTIPFSSRDKAHLAATKQYLMEGSSYFHEQATCPQTLGYALHDSPVALLAWIYEKLHSWTDNYSWTDDEILTWVSIYQFSTAGPAASVRIYYEAARKDSPSASPGLTTADVISTAAPHRVQFAVAQFRRELMPVPLSWRWLIGNVVRANEYDCGGHFAAWEVPELLASDVQAFLGRNGQAHGAVAGKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNS7</accession>
    <name>A0A2I2GNS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">feruloyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_452280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709834.1">
        <property type="nucleotide sequence ID" value="XM_024851253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNS7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNS7"/>
    <dbReference type="GeneID" id="36558952"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452280"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF2">
        <property type="entry name" value="FERULOYL ESTERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014158862" description="feruloyl esterase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB54532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="315" mass="34305" checksum="639396CC8947416E" modified="2018-02-28" version="1">MKGLSAVIAFSSITGLTTAAGSNGCGKPLPKHQSAGGDSHQTHFTTSDGTERTYLIHIPSNYDTNTPVPLIFSFHGRSGNSANQEGLSQFSNEDWNPNGIAVYPQGLDEQWQGDPASEGVDDIAFTLEMLDHFEDRYCIDSSRIYAAGKSNGGGFTHLLACDSTASTRIAAFAPVAGAYYQEVSEDDCNPITVPIECNPGRSPIPIIEFHGFEDETIPYAGGPRRGECLPSVPHFVREWSKRDGFGLHNKTTNLYDHQVQRYEYASGDAFGTVTHYRIGGLGHDWPSTGPNSDNPDGTYLDATPLIMDFFNRWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP35</accession>
    <name>A0A2I2GP35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_432267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709938.1">
        <property type="nucleotide sequence ID" value="XM_024848226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP35"/>
    <dbReference type="GeneID" id="36555925"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432267"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="115" mass="12497" checksum="AA5971FCB27BE92C" modified="2018-02-28" version="1">MATSAISMATLEFGWSVTEMALVSARDWTGNWEPTVSARRSGCSTPYGGHGEQPLAGTGRYAREWIKLCWSHDRDWAHCSLGGLALKLNANLESGLIWPHRPAGLEPGNRGICSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP52</accession>
    <name>A0A2I2GP52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_344791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709959.1">
        <property type="nucleotide sequence ID" value="XM_024843482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP52"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP52"/>
    <dbReference type="GeneID" id="36551182"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344791"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23160" checksum="3045E9F3A05F7D93" modified="2018-02-28" version="1">MIGSLFFIFNRLVEIVFLIPIIGMLAYFVDGYLKANIITPTYILVLFIVSVIAVFWCFDTLIRHSTTKRSAIFVAFVDLLFFGAFIAGVYQLRFIANADCSHWNGGSVWVSLGPFGSYGYRTDNPLSRDMNKHCAMLKASFAFGIMEVVFFSWTAFWALFMYNRSDVVVKETHVRRRSHSSRRGHGGHRRHSSSSRRPQYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPB2</accession>
    <name>A0A2I2GPB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_421364</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710005.1">
        <property type="nucleotide sequence ID" value="XM_024847355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPB2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPB2"/>
    <dbReference type="GeneID" id="36555054"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421364"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB54703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="158" mass="16839" checksum="DF7DDDEB13F0660F" modified="2018-02-28" version="1">MSSTRIFASRMASTMAATSKVARPATRVNAVVPKRTFTSQKKTIPMTPFQTLKRQQPSSLIQANARQVFANQAARRQYSSEIADAMVQVSQNIGMGSAAIGLGGAGIGIGVVFGALLLAVSRNPALRGQLFSYAILGFAFVEAIGLFDLMVAMMCKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQD6</accession>
    <name>A0A2I2GQD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_461038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710391.1">
        <property type="nucleotide sequence ID" value="XM_024851992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQD6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQD6"/>
    <dbReference type="GeneID" id="36559690"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461038"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="47"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="358" mass="39486" checksum="62CFA21F1CC0E563" modified="2018-02-28" version="1">MSSSSSSSSSSSAAADIPPARIREYSGDQTRDVAIAFIVIEIVAVGLRYLAFMLSEKRFGIDDILMIPGLILCLALNTSALIGIRLGRVGYHLDVVKALYPEAMVPWAKVLVVTPIVYSAACMVPRVVILALYLRIFHERKYRIACYVLIAVVVALGVADILTGAFECIPLAYLWDKTIPGGRCIDLTQFFRYGTLPNVFVDLLMLILPQPVIWKLQTSRQVKIGLAATILTGSVGMITSIMRCVAFFQSNPLEDGTWTSVTFLSWSIIEPGVYLLAACLPCYRPLILAAVRLTAHHTAKRSGTSYLNLSDSKSADARWKNNEPEAVELYPYQVKTGRSTEQGLPEEDKKKRIGYARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS12</accession>
    <name>A0A2I2GS12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_506221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710968.1">
        <property type="nucleotide sequence ID" value="XM_024854373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS12"/>
    <dbReference type="GeneID" id="36562079"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506221"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="649" mass="72346" checksum="AAC884D4EAF41B5C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS20</accession>
    <name>A0A2I2GS20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_343813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710979.1">
        <property type="nucleotide sequence ID" value="XM_024843427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS20"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS20"/>
    <dbReference type="GeneID" id="36551127"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343813"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF14">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT FE(2+) 2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="446" mass="48517" checksum="18A56BE9943C642B" modified="2018-02-28" version="1" fragment="single">SLRESIKGSSSTFACGGSVAIENVAYGGTPQLRGRSHPVNVFWESDSTVQKLVLPINQKNKSAVKHLQSLAGDCIPATFGRGDQDVLDPTYRRAGKLEPAHFSSNFHPADFGIIDQIEQDLLPTINDGPGSSGYRRKIIPELYKLNVYTGPSGFFHKHVDTPRGPKQIGSLVVCLPSEFKGGVLHVRNGGQDLSYDWSHASGSAIQWAAFYSDCEHEIKAVTEGERITLTYNLYATEIGTEGIPSALSLAPQSQHLYSALVKSLKEPSFMTEGGIVGLFCSHAYPHMSGTTAKSMKGLLKTSDYGLYSAIRSCGVDVDALPVSDTGSWYASIMKRLQRETNDTSKGKEEYTKMASDVWPSVQLNGITWLNEPNRDEIAFAHIPQLRGGPAPVAYGNDAVKPPVAFGNDAVKPMAFDKEKLSVVQYTDAAIFAVIQPWEKRSESLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSA3</accession>
    <name>A0A2I2GSA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_433256</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711066.1">
        <property type="nucleotide sequence ID" value="XM_024848440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSA3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSA3"/>
    <dbReference type="GeneID" id="36556139"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433256"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="391" mass="42864" checksum="6E9D1D971FF7FE0D" modified="2018-02-28" version="1">MDAGDRMFCHACGGVWLRNESGLTCPTCQSEFTEIIEIPPDTEAPDPPEEAPGDRFSPPVNPFANHNPWASTGHDEPSDDFFGGPGGGRRGSSGNGFSHRTYRSPDGRFTFSSTTYSSGFPRRQSTDPQGNLQNDPLMPMVRGLDTIFHGLANTYQQTDPHRPAGQQRWGQEHDVAESDREFGPGQSPRPAGLAGQRRAPGTMYDDPFDFGLRYGGGSDFHDDGLHPRDADGPQPMNTPLRSLGDILELFRTDFNTNNQAGNGGFRVMTGPNPLAMLSALLNVERHGDAVYSQEELDRVISQLVDQNANRSAAPPASQNAIQSLPKKKVDRDMLGNEGKAECSICMDPVEMGTEVTVLPCKHWFHYGCIEMWLNQHNTCPHCRRGIDAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRC2</accession>
    <name>A0A2I2FRC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_441642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698487.1">
        <property type="nucleotide sequence ID" value="XM_024850363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRC2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRC2"/>
    <dbReference type="GeneID" id="36558062"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441642"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="291"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="367" mass="41053" checksum="02B5145E83A5A15E" modified="2018-02-28" version="1">MVNITEKIKEIEDEMRRTQKNKATEYHLGLLKGKLARLRAQLLEPTGGSGGGGAGFDVSKSGDARVALVGFPSVGKSTFLSKITKTRSEAAAYSFTTLTAIPGVLEYGGAEIQILDLPGIIEGAAEGKGRGRQVISAAKTSDLILMVLDATKKAEQRALLEAELDAVGIRLNKDPPNIYLKQKKAGGMKITFQTPPKYLDEKMLYNVLRDYKILNCEVLVRDEYATIDDFIDVIMKDHRKYIRCLYVYNKIDSVSLDFLDQLAREPYTAVMSCELDLGVQEVVDRVWKELRLVRIYTKRKGEEPDFSEALIVRYQSSIEDVCDQIHRTLKETFKYAMVWGASARHIPQRVGLSHVISDEDVVSIVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRI1</accession>
    <name>A0A2I2FRI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_431205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698547.1">
        <property type="nucleotide sequence ID" value="XM_024848010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRI1"/>
    <dbReference type="GeneID" id="36555709"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431205"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="172" mass="18952" checksum="EF9837287BF8BF96" modified="2018-02-28" version="1">MRVYDFHAPANTRAPDGTTPIMLFSITQQALRSDIRCLLGALWSVLSRDNSSSAGASSCAACPRPRPWQLLLVFPALLNGLLRGAPGATASVIWLLFRFKAASVKKHGTYFVTVSLSSLRVSKEDKNPDYVYADKLKAKIATLEGQLKDLRKTNDTIHDTIKASSRMGWQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRN3</accession>
    <name>A0A2I2FRN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL lipase/acylhydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_419155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698571.1">
        <property type="nucleotide sequence ID" value="XM_024847265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRN3"/>
    <dbReference type="GeneID" id="36554964"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419155"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014171263" evidence="2">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="353" mass="39572" checksum="5974AA8D8DC17808" modified="2018-02-28" version="1">MFRTQLLAGILALTLDLTLARPSQGWGLRKFKSLVTFGDSYTDDSRLGYFINHNGSAPPVGWVQPESNSSSSGGYTWGHFVAQEANVNRYNYAVSGAGCSNYITPRELASIHAPFPSVLEYEIPAFVADSKHVSRGKKFLDIHPKETVYAIWIGTNDLGNDAIITDSQVKGKTIPDYIECIYSSLDQVYDNGGRYFVLMNLAPLQLAPQYATPENGGVRRSGFWKNKPENITQVSYRMWEQVATANDVFHYKTPFELLVARRYPGAKFAVMDIFGLLSHVYENPTEYFPGSASPNVTGFTKQCNDDGEDCVLAPNPESYMWFDELHPSERTSEIVAQEFVQVVKGESEWATYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRP5</accession>
    <name>A0A2I2FRP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_394828</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698607.1">
        <property type="nucleotide sequence ID" value="XM_024846075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRP5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRP5"/>
    <dbReference type="GeneID" id="36553774"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394828"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="206"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB43305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="379" mass="39951" checksum="A3A6CF941678A9F2" modified="2018-02-28" version="1">MASTVGQTITCKAAVAWAAGEPLSIEDIEVAPPKANEVRIQVHHTGVCHTDAYTLSGKDPEGAFPIVLGHEGAGIVESIGEGVTSVKPGDFVVALYTPECRECKFCKSGKTNLCGKIRATQGKGVMPDGTSRFKARGKDLLHFMGTSTFSQYTVVADISVVAVTPKIPTDRSCLLGCGITTGYGAAVVTAGVEEGSNIAVFGAGCVGLSVIQGAVKNKAGKIIVVDVNDGKEAWGRKFGATHFVNPTKLQGKTIQEELIEMTDGGCDYTFDCTGNVGVMRAALEACHKGWGESIVIGVAAAGQEISTRPFQLVTGRVWKGCAFGGIKGRTQLPGLVDDYLNGQLKVDEFITHREPLTQINTAFEQMKQGDCVRCVVDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRW3</accession>
    <name>A0A2I2FRW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_419294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698677.1">
        <property type="nucleotide sequence ID" value="XM_024847275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRW3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRW3"/>
    <dbReference type="GeneID" id="36554974"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419294"/>
    <dbReference type="OrthoDB" id="4492308at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB43375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="779" mass="87963" checksum="EC0208294A72E77E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSA7</accession>
    <name>A0A2I2FSA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_54595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698820.1">
        <property type="nucleotide sequence ID" value="XM_024855263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSA7"/>
    <dbReference type="GeneID" id="36562969"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_54595"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="160" mass="18061" checksum="547D7E6EE242F1B7" modified="2018-02-28" version="1">MDGYHTSVARNAPGHVITRPLSIPYGRYQKPVRFQGVRYAPSGIKGQPHVSPLAHNPIVSQALLEINVLLAPVPVGETQFRRWIFRRPTDSLPGLLDRCQPLRRTYDSPLRRTEYSGRINYIPGPNWMERCASRAGVLVLIAIPCRRRLAPPAPQLQHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSZ9</accession>
    <name>A0A2I2FSZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_418069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699062.1">
        <property type="nucleotide sequence ID" value="XM_024847194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSZ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSZ9"/>
    <dbReference type="GeneID" id="36554893"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418069"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="582" mass="65047" checksum="770792FA83D7635F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT56</accession>
    <name>A0A2I2FT56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative succinyl-CoA synthetase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_468576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699122.1">
        <property type="nucleotide sequence ID" value="XM_024852564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT56"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT56"/>
    <dbReference type="GeneID" id="36560262"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468576"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000017">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000340">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000098">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="689" mass="74019" checksum="7198C1F0AFCB232C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTD5</accession>
    <name>A0A2I2FTD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED16</name>
        <name evidence="14" type="ORF">P170DRAFT_459463</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTD5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459463"/>
    <dbReference type="OrthoDB" id="4139168at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="12">
        <location>
            <begin position="140"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="13">
        <location>
            <begin position="803"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB43903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="922" mass="101492" checksum="860FCCF40DA9AE44" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTX3</accession>
    <name>A0A2I2FTX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_468769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699368.1">
        <property type="nucleotide sequence ID" value="XM_024852570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTX3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTX3"/>
    <dbReference type="GeneID" id="36560268"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468769"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_bL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="110" mass="12176" checksum="E9854841AD9548F8" modified="2018-02-28" version="1">MASPTMSIAAGRWSRVLLESAPVHNLWRPAAFALNVPGLLSGVWDSVLRAVPKKKTSHMKKRHRQMAGKALKDVKNLSTCPGCGQIKRAHVLCPHCVENIKKQWKNTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU26</accession>
    <name>A0A2I2FU26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COP9 signalosome complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_441538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699389.1">
        <property type="nucleotide sequence ID" value="XM_024850336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU26"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU26"/>
    <dbReference type="GeneID" id="36558035"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441538"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="2">
        <location>
            <begin position="46"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="500" mass="56451" checksum="7713F824499E5D45" modified="2018-02-28" version="1">MAELLPRLTSVSSHSHVAASCDEAWSIQINDLIAFLKQPSNASAITSSSDYLLDNLDPSRHSLAYLFVFHLHVQSIQRTTKSPLPSEILPGGRLWLNAVHFLRHFDPVQIRYAGMEWRQLIELVAQAAQLESKPLLAVLVIRDSIFRLGITDTFTSVHLLFVRLSLLAKTYTHALPILDRQVCHLPNPSNQGYQQYRHLIPCTEHGHNAALVPETSGFSAKLAYRDHLSYFLCGAMVYTVLKDWNKAIHWLSIVISSPVTGPVSKIMVEAYKKWLLVNLLGQGKLSSPPSVVPSHVMRVYEALTKPYMSLAEAFEKCHYERFLREVEMGRTIWHIDNNTGLVSQLAPAFDKFIILRLGRTFSALKMSDVAWQRFSAGQLSPRQIEAFVASLVMSGRVSAVLFHLRDNINSTMLRFASRGGQALYYERHLRTKLNFESQLVKTIANGIDHSKSGLGFSNEHFQFLHKNQRCVDTPARVAFLAESQADSQIHGDEDIMEDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUP2</accession>
    <name>A0A2I2FUP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane GTPase Fzo1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_392417</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699588.1">
        <property type="nucleotide sequence ID" value="XM_024845974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUP2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUP2"/>
    <dbReference type="GeneID" id="36553673"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392417"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="276"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB44286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="927" mass="102296" checksum="011C66BA8EAE9266" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUV3</accession>
    <name>A0A2I2FUV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_503153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699721.1">
        <property type="nucleotide sequence ID" value="XM_024854197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUV3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUV3"/>
    <dbReference type="GeneID" id="36561903"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_503153"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="450" mass="51280" checksum="FE0B0F44617B0D1C" modified="2018-02-28" version="1">MHILWHESADEAAYEAARLSRVFNQRSPARFPLGIAKPTNESDIIAAIKLALQCNCRIAVRAGGHSFPVWSVQDHSILLDLGNFKVLEVDEAARSAKVSPSITSKELNDVLIEKHGLMFPGGHCPDVGLGGFLLQGGMGWNCRNWGWACESVEAIKVVTMQGESVFCNSQQNADLYWAARGAGPAFPAVVTEFHLRLIPYPKNGFRSSGYIYPRNRYREAFSWVLEITPTVDTDTEITVVTRYMEGQADVCVCVYFVCMKTTPEEAEAALHYIHTQQSRPSDTLTEWYCREDSLENLYDKQAKANPKGHRYHTDSAYIHNDADVVTVLEDAFLGLPRGKSFAFWSAMNPWSRRQLPDMALSMRSDHYFAIYALSEDIRDDVQHQSWVHKVMKTIENHSVGTYLGDSDLQKMERYWDSNHARYLMEICDKWDPKSVMCRYQPRRDELETKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUV4</accession>
    <name>A0A2I2FUV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_430319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699722.1">
        <property type="nucleotide sequence ID" value="XM_024847945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUV4"/>
    <dbReference type="GeneID" id="36555644"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430319"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="112" mass="10468" checksum="E37889096E134FAC" modified="2018-02-28" version="1">MDVLRNATPAAFTFGQTFAREHPTALAVGSAGLIFATAPLAGPAVLGTLGFSATGPVAAGSPFATFQGAAMGGPAAGIFTTASGLGAGIVGGTWVGYGSGSGSSDGGGGTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUZ0</accession>
    <name>A0A2I2FUZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">P170DRAFT_367993</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699744.1">
        <property type="nucleotide sequence ID" value="XM_024844836.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FUZ0"/>
    <dbReference type="GeneID" id="36552536"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367993"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="CPSase_preATP-grasp"/>
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        <property type="entry name" value="CAD PROTEIN"/>
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        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AOTCASE"/>
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        <property type="entry name" value="ATCASE"/>
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        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
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        <property type="entry name" value="Methylglyoxal synthase-like"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GATASE_TYPE_1"/>
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    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 30" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="28">
        <location>
            <begin position="607"/>
            <end position="799"/>
        </location>
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    <feature type="domain" description="ATP-grasp" evidence="28">
        <location>
            <begin position="1142"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="29">
        <location>
            <begin position="1399"/>
            <end position="1578"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="PLB44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2252" mass="247540" checksum="48B00CB0E12FFE33" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV06</accession>
    <name>A0A2I2FV06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_392749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699775.1">
        <property type="nucleotide sequence ID" value="XM_024845991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV06"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV06"/>
    <dbReference type="GeneID" id="36553690"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392749"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF3">
        <property type="entry name" value="ORSELLINIC ACID_F9775 BIOSYNTHESIS CLUSTER PROTEIN D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="469" mass="51751" checksum="3CFD4109408F01FC" modified="2018-02-28" version="1">MSTIRFGPRDLLEYDARYGVLICRECRYAIQKSAVESHLLRHKIYRSERHDLLCQIAPLQLLEPHQVPLPAATASPIEALPVISGYRCTSAGCGCLYASSKRMKRHQNVTHGRDDTNHFLSNAHPANLQTFFRGTKLRYFEVNGQVTGDPDPTIHISDKSEPDQSIVMPPRSPPLSFPLDFDLDTLTYFHHFVTATSLMLPRPKGRGSVQGYWQTDFVRRALQDQWLMCGLLALSASHMASEIEDAAIARVHRDRSVHFFAAFSAEWDATSETADLPGEIGSAARQIIGVLRCVHWGWSESIRDASNVSETTDLPQLQSILTTVRGFADSDLTLCVDKSPGITADCLQTLPSRMADFFGKPDDVRDVLATLSAIAALVDCCDMVLASTASAWDATTDWLNKVPDHFNDLVLRGDSAALVVVAHWAALLVRLVERSGCWFFGGLSTLISRLSGGGSESLLCPASLFEYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV42</accession>
    <name>A0A2I2FV42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_459045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699812.1">
        <property type="nucleotide sequence ID" value="XM_024851836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV42"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV42"/>
    <dbReference type="GeneID" id="36559534"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459045"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="511" mass="56452" checksum="651DE075027E0402" modified="2018-02-28" version="1">MKDQDIVGAALASVLPQYNKIWIRIPHLLQLNLILLIPLLSSAVAGYDGSLMNGLQSISQWQNYFGNPTGSTLGVVNAAQSIGSVLALPVTGTLSDRIGRRLTLLSGSIIIVIASAIQAASVQYGMFVFSRVLVGVGSMFVVHPSPMLISELAYPTHRGKYTCAFWTMYYLGAILASWTSYGTQKHLQSDWSWRVPSIIQAGFPIVQIAFWWCVPESPRWLIAQGRKDEAERLLARFHTAGDSSHPLIRFEMEEIVQTIELESQAAEMHWSALVKSPGNRKRTFIAACIGTFAQWNGVAVVSYYLTLVLNTVGIRDSDTQTLINGLLQVFNFIAALGAALFVDYLGRRTLFLWSAVGMLLSFIIWTICSALFDQTQNPALGHTVIGFVFIFYFHYDIAYTPLLLGYPTEIFPYSTRSKGIAVDLMCVYGSLIVLAFVNPIALERIGWHYYIFFCCFDAVVVAITWFFFPETKGHSLEEIAAVFDGPSARSGGVFDKGDGVVATAEHSENAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVJ3</accession>
    <name>A0A2I2FVJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_393035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699929.1">
        <property type="nucleotide sequence ID" value="XM_024846005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVJ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVJ3"/>
    <dbReference type="GeneID" id="36553704"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393035"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000031">
        <property type="entry name" value="BZIP transcription factor (MeaB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="301"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="611" mass="67048" checksum="B34E1B4D26AAEA28" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVL3</accession>
    <name>A0A2I2FVL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_393150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699972.1">
        <property type="nucleotide sequence ID" value="XM_024846008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVL3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVL3"/>
    <dbReference type="GeneID" id="36553707"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393150"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="465"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="832"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="998" mass="109516" checksum="D030531972F7CFE2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWL9</accession>
    <name>A0A2I2FWL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_513116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700341.1">
        <property type="nucleotide sequence ID" value="XM_024855064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWL9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWL9"/>
    <dbReference type="GeneID" id="36562770"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513116"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="395" mass="44819" checksum="6FEBD27A23C61C54" modified="2018-02-28" version="1">MSDALPTLPFDFLTWQDAVKKHDLVGQTVHTAELASASKMTYEQFLLLRILWITHLGIHRFRLPPVLEPHLIQANKLLAESQSWTQYCKSIKAARTTEGSFAIARHYQIKADNTKGHLRPDSFDTPIAMRTRSHTRKLEQEFKTLQLNQTPTKAPTPAPQITEPEKNDDDDSIFLEGSDASEESEASSIPVTPAALISGELHRLMFPPTKDEQIVNTALVVFLNALTIHFDVIAHCDWTLHRKAFTVQFEAAKYEARTDGYLDDGRENPWALIEVKPVTRAQFNQGRIQIQEGSQMSGWIKEEIDAPLDKLRVHVSQNRHEIFITVAEYDSGYISYLRKKPADDEPLSFLTMHQYGPWNTNNAGHMKKLGPILLALTLYADAEVKKAELLNSLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX77</accession>
    <name>A0A2I2FX77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cytoskeletal adapter protein sagA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_440361</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700515.1">
        <property type="nucleotide sequence ID" value="XM_024850061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FX77"/>
    <dbReference type="GeneID" id="36557760"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440361"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
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        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
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    <sequence length="1282" mass="134631" checksum="66F96926214C42A3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXA4</accession>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 23096</strain>
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    </reference>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="1"/>
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        <location>
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        <location>
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        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="703" mass="78691" checksum="C6248A9FA7AD7A59" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXJ6</accession>
    <name>A0A2I2FXJ6_9EURO</name>
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        <submittedName>
            <fullName evidence="8">Cap-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_439127</name>
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        <name type="scientific">Aspergillus steynii IBT 23096</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024849766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXJ6"/>
    <dbReference type="GeneID" id="36557465"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439127"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="275" mass="30316" checksum="86681198E0735C58" modified="2018-02-28" version="1">MAFQPTPTDVTAIITTPSTGPNAGPQFQNERRITPTWTVMQLKSKLETMTGIPPGSQRLHLKSPGLPSRWIDGDETVIGEWGLVRGCEIEVHDSRPQSARPNFNDLSSVEKYVLPTTTYESLPNSVLAWKKNQKLGRFDPNALSPEESMRKQAEQDAEEVARKEIAVSRRAIILPSSPPHVRRGTIRFVGPVPTIPYPGVNDKSESSKVDSDDSLPMWVGIELDEPTGKNDGSVGGQRFFTCPSKSGLFVKPEKIEVGDFPPLDLDDDLGDLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXM7</accession>
    <name>A0A2I2FXM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_413460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700664.1">
        <property type="nucleotide sequence ID" value="XM_024846981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXM7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXM7"/>
    <dbReference type="GeneID" id="36554680"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413460"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000219">
        <property type="entry name" value="tRNA (Carboxymethyluridine(34)-5-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="242" mass="27461" checksum="EBCE5C00A1BA8A42" modified="2018-02-28" version="1">MASSEAATEHPNDEYEEKNVHEVYQQIANHFSATRYKPWPIVERFLKELTPGAVGLDVGCGNGKYLSVNQDVFIVASDRSENLARIAVKHQPHSTIVADILNLPHPDSFFDFALSIAVIHHLSTPDRRIQAIREILRTLRPAMPNAPGGKALLYVWALEQKTSRRGWDKGDQKDVMVPWVMKQKASQGHSDEEPKVFHRYYHLFEEMELERDIGAAGGLVLESGYDRDNWWAIATRSDQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYH3</accession>
    <name>A0A2I2FYH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_249646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700979.1">
        <property type="nucleotide sequence ID" value="XM_024843015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYH3"/>
    <dbReference type="GeneID" id="36550714"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_249646"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="150" mass="16226" checksum="7531782839605185" modified="2018-02-28" version="1">MEMSLRIQSRHLQSATNHSPSFLCRLSVLFIRPVPGLGLVSVLDSVDSVLAAWQSEQIVGLPLLIPVISGEWSGMVQIPHSQSPSHLGPRRKSQQSTVHSPHGRDNATDGLLLRGKVARPYGSWDLLASIVSSPCSFSGAIGWIPQSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZL9</accession>
    <name>A0A2I2FZL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_259629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701375.1">
        <property type="nucleotide sequence ID" value="XM_024843069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZL9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZL9"/>
    <dbReference type="GeneID" id="36550768"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_259629"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="546" mass="61932" checksum="2A38ED0153BE1811" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZT4</accession>
    <name>A0A2I2FZT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_479005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701388.1">
        <property type="nucleotide sequence ID" value="XM_024853614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZT4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZT4"/>
    <dbReference type="GeneID" id="36561312"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479005"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="82"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="529" mass="57955" checksum="8AC896590AEEB03A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0P9</accession>
    <name>A0A2I2G0P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rh-like protein/ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_362100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701745.1">
        <property type="nucleotide sequence ID" value="XM_024844510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0P9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0P9"/>
    <dbReference type="GeneID" id="36552210"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362100"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF9">
        <property type="entry name" value="SIMILAR TO AMMONIUM PERMEASE, BUT NOT NORMALLY ACTIVE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="449" mass="48481" checksum="D065E393AF17DF7E" modified="2018-02-28" version="1">MSVQAAWDACSKTDTLFILVCSVFCWLIIPAVGLAYSGYSTRFNSLSSFYPGLLAVAVCSIQWWMIGYSLAYGDANSVFGGFSKIFHIGVLSNPVGSIPEILFSEFQLIFCATVCAIAIGGACERGRLLPLIPFIFLWCTFIYAPLAHMVWSETGFLATLGTLDFAGGTPVHICSGATATAMSVYLSYPLFRSRRSASRTPQHLVLHKPHNSLCQLLALIIIWNAWLVFDAGTTLALNFKSVMAACVTNLCAASGALTWASLTYWETGKWSLDSTFLGAIAGLVLITPSAGFIDMNTAVGFGVLGAVLGRQALRIKFTKMAARWRWVDNGDTFATHCLGGFVGTIVTGLFAQREVAAYDGVTVIAGGCVFDGNWRQLGVQVVEALIGFVWSFGGSYVLYALVDCVPGWEVLATDEEVIAGMDASQMDESLHAAQWAGEEDYHPFKPLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0R4</accession>
    <name>A0A2I2G0R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_216437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701763.1">
        <property type="nucleotide sequence ID" value="XM_024842835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0R4"/>
    <dbReference type="GeneID" id="36550534"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_216437"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="94" mass="10855" checksum="0F656FD43DF40895" modified="2018-02-28" version="1">MPAKLVDSYTGHGTFTLCTDSERSFRTPATVYNNGDREHIRSQIAKKYWDLISQVPETLKKTTRTLIIGISTNDLQKTLFMDHWHCIYATVVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0U3</accession>
    <name>A0A2I2G0U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_466003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701806.1">
        <property type="nucleotide sequence ID" value="XM_024852377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0U3"/>
    <dbReference type="GeneID" id="36560075"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466003"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="229" mass="25471" checksum="556B9A7C2A011A26" modified="2018-02-28" version="1">MSITNIALIPGTTTDHGTLDTLIDRYKNIRLRALKEEPQAFGSKYEDELQFPHHRWQARIQNPRAHTFIALNVSPGFDVLVKSAGDSDPSLPVLLTTEWLGTLTMIGPEAVPDSNLDAKELLDLFDRNRAISSGDGTHGSVMAYVLNGMFVAPEGRRSGNGRRLVERAVGYARDAATAVGAVQVWMLVFVEVENGPAFEFYQKFGFQAWDGEVLLGHRYVRMLDLRIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G122</accession>
    <name>A0A2I2G122_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_511310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701875.1">
        <property type="nucleotide sequence ID" value="XM_024854876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G122"/>
    <dbReference type="STRING" id="1392250.A0A2I2G122"/>
    <dbReference type="GeneID" id="36562582"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511310"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB46573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="436" mass="49817" checksum="A13B9B0C58F1A9A4" modified="2018-02-28" version="1">MTFPRRPPGRRLPWICLLGLLLTLYVFFGRTTTTSTTSRPDHVPHNATAPCPALPGMDNMLVILKTGVTEAREKVPTHLQTTLRCVPHYAIFSDYAEEINNVQVHDILRTVPDPVKWMNPEFNVYQRVRQAGRTALTTADLNEDVNGVFGKPNNPGWKLDKWKFLPMIEEALKVRDDAKWYVFMEADTYFVWRNLVAWLEQFDSSRPYYLGNQMQILDVLFAHGGSGIVLSRPAMEAAVRTRRSDVARWDAITRDNWAGDCVLGQLLAESGVGLLWSWPALQIGPPGEMDAFSPDYYKTPWCYAPVTFHHLRPREVEDLWRLDREWFGAGNELLLWRDVFLRAVRSQLMGVRYDWDNRVAPQNSISSRSRSSVECRRKCMSDPDCVQYAQESDTCWLSATAKLGTAATGVISGWIPERIDELVQDMGECSQAQWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G145</accession>
    <name>A0A2I2G145_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_438321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701905.1">
        <property type="nucleotide sequence ID" value="XM_024849577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G145"/>
    <dbReference type="STRING" id="1392250.A0A2I2G145"/>
    <dbReference type="GeneID" id="36557276"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438321"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="595" mass="68243" checksum="E902743147B95AE4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1H8</accession>
    <name>A0A2I2G1H8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative prefoldin subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_466150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702034.1">
        <property type="nucleotide sequence ID" value="XM_024852391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1H8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1H8"/>
    <dbReference type="GeneID" id="36560089"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466150"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="121" mass="13606" checksum="9C76A01BD2DFA6E1" modified="2018-02-28" version="1">MSIPNEALQKLLQELETRIVASQQQIGITKAQITTKQRDIRMLELTSKEIGSLPKDTNVYEGVGKMFMSVPMNTVDKRISTESTELKSDISGLEKKLSSLEMTHKNGRENLERILKSGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1H9</accession>
    <name>A0A2I2G1H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sulfate/bicarbonate/oxalate exchanger SAT-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_220686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702025.1">
        <property type="nucleotide sequence ID" value="XM_024842858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1H9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1H9"/>
    <dbReference type="GeneID" id="36550557"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_220686"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000141">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="624"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="677"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="747"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="964"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1078" mass="118249" checksum="FCF7282774417064" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G277</accession>
    <name>A0A2I2G277_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cholesterol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_438704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702295.1">
        <property type="nucleotide sequence ID" value="XM_024849664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G277"/>
    <dbReference type="STRING" id="1392250.A0A2I2G277"/>
    <dbReference type="GeneID" id="36557363"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438704"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="235" mass="26233" checksum="377C0D31BE695114" modified="2018-02-28" version="1">MWVLPLLGYLGVIVGFSFLTLAIASGLYYLSELVEEHTVLARRLLTRLIYGVVLIQILLSVVDRFPLSLSLLSIGSHLVYASNLRRFPIVKLSDPLFVLSCVLVGLNHWLWFRHFSRPLPTSRAGTNWRNPYQVDVDDMPTFTEVASYFGLCVWLVPFSLFVSLSAGDNILPSMGSEYATGEHVSTAGFANNALSSEGKSKNKGMAKALVDGTRDWVRENGELMGFWKGDHSKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G282</accession>
    <name>A0A2I2G282_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF1640 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_438686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702277.1">
        <property type="nucleotide sequence ID" value="XM_024849661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G282"/>
    <dbReference type="STRING" id="1392250.A0A2I2G282"/>
    <dbReference type="GeneID" id="36557360"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438686"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="311" mass="35172" checksum="CF533FD7A8C80B00" modified="2018-02-28" version="1">MAHQKSVTEVPRSILPRLTWNGSSARTTVPPCQTNTLSARRQQKQRHIHGWNSPGRHIHTWSPSSRPSASVSSLREPRSSLSPVGQTPLTRSGATNRPTSETASNPIRYNGVYATTFKAARRAFHASAVRQRDHHFDTLKFVQRLKDEGFSEEQAVAMMRVLNDVIQESIQNLTRTMVLREDTERSTYTQKVDFAKLRSELLNADSTEAQLTRSSHEKIAADLAKLNSRLRDEIGRTQASVRLDLNLEKGRIREEANGQEMRIKETETRIEQEVAGLRERVEAVKFSTLQWLMGVCTGTAALILGAWRLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2B1</accession>
    <name>A0A2I2G2B1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_438707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702299.1">
        <property type="nucleotide sequence ID" value="XM_024849665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2B1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2B1"/>
    <dbReference type="GeneID" id="36557364"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438707"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="247" mass="27109" checksum="A141CC7FD05979C8" modified="2018-02-28" version="1">MDPTPTADKVGYSACNQYDIPRSEDDLGEQEDLVARFARQMTMAATQTPSGASSQAPLPIVYSITQHYHHSSHVAHGGTPDGAQKGHVLMSSDPTRLDGILMSHDVDPSSLSSMQRRLFEHAMPDQRARLLQMWQICPANSLSIAETMEGGHARNLADRPTRTAPNQTMQPSHFYDVEMCDQVQGDNNDDGHRYAEPYMVSGYDDIDQKDCEQRAHAFMSLTVEPTTGAPYKIANDPVYGIGGSGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2G6</accession>
    <name>A0A2I2G2G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_428301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702376.1">
        <property type="nucleotide sequence ID" value="XM_024847835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2G6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2G6"/>
    <dbReference type="GeneID" id="36555534"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428301"/>
    <dbReference type="OrthoDB" id="3561737at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024436">
        <property type="entry name" value="DUF3824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487:SF1">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12868">
        <property type="entry name" value="DUF3824"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="379"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="532"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="849" mass="96626" checksum="726832EDD00AC5B9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3J7</accession>
    <name>A0A2I2G3J7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_465142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702758.1">
        <property type="nucleotide sequence ID" value="XM_024852301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3J7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3J7"/>
    <dbReference type="GeneID" id="36559999"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465142"/>
    <dbReference type="OrthoDB" id="4357769at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="266"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="338" mass="38612" checksum="EAF358F4F159897C" modified="2018-02-28" version="1">MTLEDGPEFPFFCHICGAPPTWRGLLADSTLQYLDPEEEYFDQRAYRYMDFMPGQRKFGYDVRLLPPKQIRWLDAVRLVTNKIMDSVRGTETEVPVPLLTRLALHVHIDNGAFCCPDNDNDSKKFSFMRCNVDGYLVHDTCFKMLERVHQHLQATWSTQDLDLGRLWNLLQLGLEDRNNDLVDWGFGDAFHGSDRGSSGARFNPYYQEWHPVKGSMWAVMDPEGPFNCQPLLDRASASTQPGYSFTFSVKPTQPNPPAHLHPEPNMNFLSLLPYELQLSILELLPSSSVLSLLLASPDFRRCAEHLSSGFWKSRLFFDVPWCADIISAQIEAAQGNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3P6</accession>
    <name>A0A2I2G3P6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Steroid monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_385179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702789.1">
        <property type="nucleotide sequence ID" value="XM_024845711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3P6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3P6"/>
    <dbReference type="GeneID" id="36553410"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385179"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="570" mass="63917" checksum="7021965E309FE685" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G455</accession>
    <name>A0A2I2G455_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702953.1">
        <property type="nucleotide sequence ID" value="XM_024853338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G455"/>
    <dbReference type="STRING" id="1392250.A0A2I2G455"/>
    <dbReference type="GeneID" id="36561036"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476334"/>
    <dbReference type="OrthoDB" id="10264449at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252:SF1">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="134" mass="15413" checksum="104999AF74153D98" modified="2018-02-28" version="1">MPTTEQVRAIFASFEEGNAPSFFQHVVDDVDWEVKGTFCPIAGRYKSKAEFHEGTKSLSSTWASPLKLQVRNVICDGHQAVVEMRAMDTKCWNGLPFTNEYAWVCEFNDQNQIIRIRAYMDTDLVCRAIRENQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4P8</accession>
    <name>A0A2I2G4P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_360261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703157.1">
        <property type="nucleotide sequence ID" value="XM_024844404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4P8"/>
    <dbReference type="GeneID" id="36552104"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360261"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="58" mass="6886" checksum="FF1E9C927DF1E8A5" modified="2018-02-28" version="1" fragment="single">EYYYINKSLILILLLIKNLILSANKILISDKKILYYILRILQTKLAPTNKSRKHDIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4Y7</accession>
    <name>A0A2I2G4Y7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5 13">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_476591</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5 13"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703240.1">
        <property type="nucleotide sequence ID" value="XM_024853365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4Y7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4Y7"/>
    <dbReference type="GeneID" id="36561063"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476591"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000049">
        <property type="entry name" value="Amino-acid acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="521"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR007892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB47938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="700" mass="76973" checksum="FA9431C02CAB5994" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6A3</accession>
    <name>A0A2I2G6A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YWTD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_438049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703701.1">
        <property type="nucleotide sequence ID" value="XM_024849500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6A3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6A3"/>
    <dbReference type="GeneID" id="36557199"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438049"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="311" mass="34370" checksum="373890EC49F674FE" modified="2018-02-28" version="1">MAPRPDFSQKPSGRLYFLDVGITTPEINGRLLTCKPDGSDLRELITHINTMPDGIAIDTDRQHIYWTNMGVPSADDGSIQRCDLSGNNIVTIIPKGYTHTPKQLTIASQSQKLYWSDREGKRVMRASLDGSEIEVLYRAASSDDTGRPPVYDWCVGIAVDEESQKIYWTQKGPSKGNQGRIFRMGLEMRQGESAERRTDVECLRDGLPEPIDLELNHASRTLYWTDRGDPPRGNTVNSMSLVDGLESKLESKILVRKLHEGIGIALDLKNGRMFFADLGGSLYSANLDGSCKSTILSDVGGAITGVAYVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6B8</accession>
    <name>A0A2I2G6B8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_465789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703728.1">
        <property type="nucleotide sequence ID" value="XM_024852352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6B8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6B8"/>
    <dbReference type="GeneID" id="36560050"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465789"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="633"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="6">
        <location>
            <begin position="773"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="108950" checksum="21BE5B901D03C660" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6B9</accession>
    <name>A0A2I2G6B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_360491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703723.1">
        <property type="nucleotide sequence ID" value="XM_024844412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6B9"/>
    <dbReference type="GeneID" id="36552112"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360491"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="140" mass="16090" checksum="89E4C2A8941CEAB8" modified="2018-02-28" version="1">MPLWQIHHGSQTLTDEDKQTLAKQITQVYVKYGLPAFYVQVEYQEMSPTTSFTGGEHNPKFVGLTIYHLAREMSSDAQVKRFLGDIDAVLTPLFEPKGLDWEYFVTEAPRHLWKINGLVPPAAGSEEEKEWKRLNRAIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6F3</accession>
    <name>A0A2I2G6F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fasciclin domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_511048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703757.1">
        <property type="nucleotide sequence ID" value="XM_024854845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6F3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6F3"/>
    <dbReference type="GeneID" id="36562551"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511048"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="403" mass="45092" checksum="B5D926E696E0B266" modified="2018-02-28" version="1">MSVNWKRCSRLARRVTRATVIVATVALGIQFFARNLLQGTIHPVRVPETTAIDNSPMTVWELIRNDNRTSTFANILGQFTGIAGGLNAPKAQFTVYVPTNEAFEQEKFAEDLPIFYWMYLVGYHMGPGAFTREMLSRMNTAPSFVFADIYQKYRQRISLHGLSNRLSFNYRAHYATADYSLAGVNGHVHLVDRVLMLPESTSDLLRDDRDFSTLREGLTLTDVAVTINDTSTHVGQTLFAPSNAAFDKLGAKTKKFLFSPGGRQYLKALLEYHVVANRTMFTDIYFQESGRGEIPLQKGSTLDLPTLVPGYNLSISIDAGDSARPSPLINNEVRITQSDLVVMDGVVHKLDTVLLPPRSPRDDTEGQQQSWFGSLVHWVTSDSDVKVGELVRRLEEFMDGAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6H4</accession>
    <name>A0A2I2G6H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_411343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703774.1">
        <property type="nucleotide sequence ID" value="XM_024846888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6H4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6H4"/>
    <dbReference type="GeneID" id="36554587"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411343"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="292" mass="33342" checksum="3522E21B0D7B8FB1" modified="2018-02-28" version="1">MQQPPCPQCPRGYDTLAHLMALDPGLSFFRRFTVLNTKNLLYLQAELSLAEASLKDIVHEDQESGSQTKKAYPYSVEALLESYNVEGDSANAAQWSKVLEVRKMLKEHNEALLQHTQLLRLSSPERSDLAMFQEWLDAQEAREGTFLRPRHQWRDDGNTNDLVALRSRFEGTDLLTRWMFTKLVPWYHQRFGVRNSTLSNHAVHAWIYDDRTVRRTSYFISLVTAGVLPASSIIVLLYLKKTTIRMVFVIVYNLAFVLIMGWMVKARRADLLAVSTAFAAVQVAMIATNDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6T3</accession>
    <name>A0A2I2G6T3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_455559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703886.1">
        <property type="nucleotide sequence ID" value="XM_024851543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6T3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6T3"/>
    <dbReference type="GeneID" id="36559242"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455559"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="508" mass="57491" checksum="963246F62BED23FB" modified="2018-02-28" version="1">MLAIIVFGGTALVALAYLFTLPVALYFLDRKGLRKYPSFSPLSGFTDLRHIYLSACGYRSRDLYEAHKRAPILRTGPNSLSFGDTQAVRDIYGHGTKCIKDLNYVVLGGTHTHLFDVVDRSEHSRKRKILSAAFAIKNLERWEFKVARTTGRLLRALDNHCTGPLPDGQAIASPVDLTLDFGKWINLFTIEAINSIALSANMDLLDKGTDEVTAQRLDGTTYKARYRQAQNQSALGQATFVWDYQHYPWLVKLSKLSPKWREVWQKAQPWDDVIYHQAATRLQRYLNGEELDDFFSSLMEDKQKKPNNLEWGEIVAEVSAIINAGADTTAIALTQTLREEVDSVLDEDEVVAAHDKVKNLPFLRACLDEALRILPPTSAGLPRRTPPEGAQIMGEWIPGDTSVSMTIYAAHRDPDIFPDPETYRPERWLDAEARKRMEPYFIPFSAGARGCIGRNISYLEQTMVLASLVHRYEFALPSSDWKLARHEAFNLIVGEMPIKIWRRQMGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6Y2</accession>
    <name>A0A2I2G6Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703941.1">
        <property type="nucleotide sequence ID" value="XM_024847658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6Y2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6Y2"/>
    <dbReference type="GeneID" id="36555357"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425677"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="252" mass="28550" checksum="FCCA65D5E45F7005" modified="2018-02-28" version="1">MPDYSEICRSSQFTFLVGKQRTPIKVHSAVFKECSRPLAALINNGIMKESTDRVAVLADVDPEVFTAVCEYAYTGSYKSPSLDPADNQVMRLLSSALDEIMASLPTLATQSYNLLAEPGTARYVERCKTLSSKLSDLRTALSVNGVACALFHAKLYIFATKYLVEELRQLSLRSIYQDLTRYFFSTDEICDLLEYVYRHTGSVEHDGRSSLRRMLIRYVAVRMWRYSSDKRFSDMLQSNGEIGADLIQKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7A0</accession>
    <name>A0A2I2G7A0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_167479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704040.1">
        <property type="nucleotide sequence ID" value="XM_024842606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7A0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7A0"/>
    <dbReference type="GeneID" id="36550304"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_167479"/>
    <dbReference type="OrthoDB" id="5386278at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="67668" checksum="DCDA28C156DFCA69" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7C6</accession>
    <name>A0A2I2G7C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_358201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704084.1">
        <property type="nucleotide sequence ID" value="XM_024844269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7C6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7C6"/>
    <dbReference type="GeneID" id="36551969"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358201"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="557" mass="61359" checksum="BAAC3DD7AD7A2BEC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Z1</accession>
    <name>A0A2I2G7Z1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_383532</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704304.1">
        <property type="nucleotide sequence ID" value="XM_024845643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Z1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7Z1"/>
    <dbReference type="GeneID" id="36553342"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383532"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB49002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="376" mass="40981" checksum="0D0AB19CBB3BE45E" modified="2018-02-28" version="1">MPAGSVLVAGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALKRIELISGKKAEFAQLDVTDEAAFDKVFEAHPDIDSVIHFAALKVVPLTAVGESGEKPLDYYHVNVYGTICLLRSMVRHNVNNIVFSSSATVYGDATRFPDMIPIPEHCPLGPTNPYGNTKFAVENAITDVINAQRNNAIKAGNEAEAKKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVFGDDYASHDGTAIRDYIHILDLADGHLKALNYLRANNPGVRAWNLGTGKGSTVYEMIRAFSAAVGRDLAYEVAPRRDGDVLNLTANPTRANTELGWKAERTLEQACEDLWLWTRNNPQGYRQQPPAELLDQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G846</accession>
    <name>A0A2I2G846_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_383593</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704337.1">
        <property type="nucleotide sequence ID" value="XM_024845645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G846"/>
    <dbReference type="STRING" id="1392250.A0A2I2G846"/>
    <dbReference type="GeneID" id="36553344"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383593"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000116">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000018">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="17">
        <location>
            <begin position="187"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB49035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="486" mass="52988" checksum="5F3264E36E3AE961" modified="2018-02-28" version="1">MSALPSAVTALSAPGKVLLTGGYLVLDRKYTGTVFALDARIHIVVQQLRRGHRRGASGSGKPGDSAPTGTAEEGTAVDDKDNEDIVVVRSPQFIDALWEYSIQRCENGGGIKVIQKNEGRHNPFVETSLNYALTYISYVADSKDFGSLSITILADNDYYSETAFSKASEMQYAGRFVNFGVPLHEAHKTGLGSSAALVTSLVSALVIHRTMQPDDLGAARDKLHNLAQAAHCAAQGKVGSGFDVAAAIYGSCLYRRFSPSILESVGDVATPGFEERLFAIVEDVNPQHPWDTECLDFGMQLPRGMQMVLCDVECGSQTPSMVKKVLEWRKQNPQEAELLWTALQSNNERLCLELKQLAQNPNHEQANDFSDVRRLIQRSRNHIRSMTQKTGVPIEPKVQTELLDVVSDIEGVVGGVVPGAGGYDAIALLIRDDGEVIQKLNDLFETWESKVEDDFGGKIGQVRLLGVRHGSAGVKNEPLDQYSGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G883</accession>
    <name>A0A2I2G883_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704380.1">
        <property type="nucleotide sequence ID" value="XM_024853256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G883"/>
    <dbReference type="STRING" id="1392250.A0A2I2G883"/>
    <dbReference type="GeneID" id="36560954"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475401"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058535">
        <property type="entry name" value="MafB19-deam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF179">
        <property type="entry name" value="TRNA(ADENINE(34)) DEAMINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="17666" checksum="4D151BA5A65E5B31" modified="2018-02-28" version="1">MVSTTDITHLRRCVELAREALNAGDSPFASVLVSAEGTVLKEDRNRVVTEADVTRHPEFTLVQWAQKNLFPTQRAATTVYTSGEHCPMCATAHAFAGMGRIFYASSTAQLLAWRKEIGMDSDLVAPLAINQVAPGVPVEGPVAGLDEEVKELHRLKHLWANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9U3</accession>
    <name>A0A2I2G9U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF218 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_358384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704940.1">
        <property type="nucleotide sequence ID" value="XM_024844288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9U3"/>
    <dbReference type="GeneID" id="36551988"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358384"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="269" mass="29305" checksum="2FF563C21A227F8F" modified="2018-02-28" version="1">MTTTISPEDVNRLSSFLAHEQIQIPTTTPTPPAADCIVICVSAILDAAETVFTHLEQCPTLTKTLVLCGGIGHSTPFLYDAVARHPRFVHLAADIQGLPEARVLHCLFTRCFDAERIQSAGCRVLVEDGSTNCGANAIFTKELLRRSGVEVGSVLVVQDPTMARRTVASFEKVFASTGTESPRFASWPVFVPRVALQAGELVYNVPGIPADRLWSLPRFLGLIVGEIPRLRDDAEGYGPKGKGFIAHVDIPEEVEAAWERVKGLDMARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9X3</accession>
    <name>A0A2I2G9X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_409248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704981.1">
        <property type="nucleotide sequence ID" value="XM_024846764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9X3"/>
    <dbReference type="GeneID" id="36554463"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409248"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="564" mass="62809" checksum="539155AC2A88EEE6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA20</accession>
    <name>A0A2I2GA20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_495912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705029.1">
        <property type="nucleotide sequence ID" value="XM_024854089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA20"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA20"/>
    <dbReference type="GeneID" id="36561794"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_495912"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB49727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="355" mass="40318" checksum="0DDC0E43B7EC2E75" modified="2018-02-28" version="1">MASFAASVVRNSVFRTPSSAFRRVSSRTLTTRATSYTLNTGAKIPALGFGTFQDPDSQEETVSRALKKGMRLIDTARVYDVEEQVGRGIKKSGIPREDIFLGTKLWCSDYHPEDVERAVDDSLRDLDTPYVDLLLMHYPCTFKRGPDRFPRDAEGRIVHGETTFVDTWKAMEKVTRTGKVKAIGVSNFSMGEIKTLLDEASTVPAVHQMEVHPYLQQKEFNQWLQNLGIHVVQFSPLGNMNDFYRQTGWSKEISHMMRVIDQPVLKEIGEKYNKSPVQVVLAWGINSGRSVIPKSVVDWQIEQNLEADFELQTENMARIATLDAKARFNDPSLDYEWRLYSDLEGIDGTMRGKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA36</accession>
    <name>A0A2I2GA36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_409317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705043.1">
        <property type="nucleotide sequence ID" value="XM_024846771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA36"/>
    <dbReference type="GeneID" id="36554470"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409317"/>
    <dbReference type="OrthoDB" id="4225164at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="264" mass="30565" checksum="153506500B2478F2" modified="2018-02-28" version="1">MVSSKIPPIQGKSICRGTIEEVLKIYNNSSHPLTIFSRSSDRSRERNEVPYYRFRKIFFTDDTEVLQGNRSSEARCVRLTAFIAKQDEDHPNPYIFVEQSVRRAGRERIMIYELQFGGKVIPDREYIFPDCGDEDPHRYPGQRDLLLSVRSLQQDIFDDYIRRATYYGYDWKDWAWVNQHALKHGLEYELSRPKILGESTVKVSFDPADLQALVDAKRAMHLATGGQASDKIELLKLRFKGLGSCTEDGIQSGDLDLRIVYKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAB4</accession>
    <name>A0A2I2GAB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_358411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705119.1">
        <property type="nucleotide sequence ID" value="XM_024844291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAB4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAB4"/>
    <dbReference type="GeneID" id="36551991"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358411"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="510" mass="57607" checksum="A1F23780D0F907D0" modified="2018-02-28" version="1">MSLFNFILLPLEGSVILLIGYLLVNEFIRWNRRIKGLPGPQGLPVIGNLRQVTQSFSAEQYRQWSEKYGPVYQVQLGNIPVVIVNTADSAKSLFLNQSSALISRPLFHVLHKTVSKSVASIGTSPWDESCKFRRKLAAGALNRPKVQSYEPIILLETREFIQELLQASCENTEVEFKPTVHRLSLNLVLTLNYGTRVSSTKDLQEDALYAEIIEVENEISRFRSTSKNLTNYIPLLRLLEPLLWKKSAAYSAQIGQRRIAYNNKLLNRLKEAVKYDTDKPCIQGNVLRDPESVGLSSKELLSISLSMMAGADSTQPTIAWAILFLAHNQHVQQRAFNEIQRSGAIIDSKVETQEVEYIHVLTKELMRVYTVLPLGMPRETTETVHFEGRAIPPGTMVFLNAYGCNRDGDAFADPWTFKPERWLDNAEKHTHQFAFGYGSRMCIASHLAFRLVYTAIFHLIATFEIHPMHGQSKDAADPVVGLKDPTSITAVPRAEKARLVARELTKRNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAV5</accession>
    <name>A0A2I2GAV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_424443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705316.1">
        <property type="nucleotide sequence ID" value="XM_024847570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAV5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAV5"/>
    <dbReference type="GeneID" id="36555269"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424443"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="32"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="598" mass="67241" checksum="12A5524549622924" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAW2</accession>
    <name>A0A2I2GAW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_473596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705324.1">
        <property type="nucleotide sequence ID" value="XM_024853064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAW2"/>
    <dbReference type="SMR" id="A0A2I2GAW2"/>
    <dbReference type="GeneID" id="36560762"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473596"/>
    <dbReference type="OrthoDB" id="4469620at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="128" mass="14468" checksum="E7F33F57A5BE2BA4" modified="2018-02-28" version="1">MDLKSRAQLFLNTIVNKRETSSIASILHPDLELRHDDLPPMSKSEFIDFWPQVLADSPGFNVQIQRVIAEGLQVWVYSRVTGRFGGGLLDDVHILDFDENGLLIRSKGMQREVCENSEGGEKREAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB61</accession>
    <name>A0A2I2GB61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1740-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_354741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705425.1">
        <property type="nucleotide sequence ID" value="XM_024844056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB61"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB61"/>
    <dbReference type="GeneID" id="36551756"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354741"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1154" mass="131317" checksum="9672C3BBAD21D875" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBD2</accession>
    <name>A0A2I2GBD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin C-terminal hydrolase Ubp8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_445557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705495.1">
        <property type="nucleotide sequence ID" value="XM_024850723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBD2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBD2"/>
    <dbReference type="GeneID" id="36558422"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445557"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02660">
        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000127">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase Ubp8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="165"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="491" mass="54496" checksum="A13215B52599E04A" modified="2018-02-28" version="1">MASVASVTLLSEAEFGCEHLATQLAHAGSAANQFKNSFLKTHNALAPQPITAEMIAKHTAGSRSYSLLRPRYTCLTCSEACNPSGREKHTEKTGHSFFMESRNRALYCQSCEDLIYDHGLERLRSSSSENTLKVAQKRRFSESSADELYVRSNANRRLCAKAGARGLYNLGQTCYMNVILQTLLHDPILTTYFLGNGHPHHHDCQTPDCTGCAVAEAFADFNSTEKLDGFAALNLLVATWRGSAALAGYHQQDAHEYYQFLVDKLHATTDGHQENHEKGCPCFFHKTFYGKLRSSVTCDKCGNVTRTEDPMVDLSLDVQVQAKKRAMGGSGPSSPPTLTGCLESFTSPEKLMAGVYNCTSCGDTPQKATKQLRIKKLPAILCMQLKRYEHTFSVSEKLEGRIDFPLSINMLPYTTNPHPLTDRSRYLYDLSSAVVHKGKLDAGHYYAYCRQGDQWMLFNDDQVTPATEADVLNADAYLLFYNLRSLAGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBZ6</accession>
    <name>A0A2I2GBZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_473958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705703.1">
        <property type="nucleotide sequence ID" value="XM_024853092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBZ6"/>
    <dbReference type="GeneID" id="36560790"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473958"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014121273" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="90" mass="9517" checksum="A3FF828D91A6D684" modified="2018-02-28" version="1">MQLLTFSALATAFLAVFAAANPVELEKKEAEPNRGYYAEEYYRRPAAYYGPPAGAGIGIGANADAAADAHVGLEMRVSWPWAAELLGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCB0</accession>
    <name>A0A2I2GCB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_445804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705820.1">
        <property type="nucleotide sequence ID" value="XM_024850740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCB0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCB0"/>
    <dbReference type="GeneID" id="36558439"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445804"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="239"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="523"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="753" mass="83633" checksum="9B95B9AE2C79D974" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCJ5</accession>
    <name>A0A2I2GCJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_435794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705906.1">
        <property type="nucleotide sequence ID" value="XM_024849022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCJ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCJ5"/>
    <dbReference type="GeneID" id="36556721"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435794"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="326" mass="37000" checksum="33B920983310A685" modified="2018-02-28" version="1">MRDMTDSYYYAASSSRIKTILKCHDVLLVHGFLLSHRGLILATMASVSYMLSPAQEQITTSALAFRTESDLLSQILSGVIQRARHKELVYTDVEPAWGSHIVQSLNVHEDEESACSRLHYNSVTKVLWVRLMPTEIHACHQLWVRNENYNWMVSGQLTLEELKKLRTKVGMPIRTFKPPYDKSCKEPDLFIRPGTQRLPSVVVETGWEEAYPRLRNDVDLWLLGGRPYVKVVMLLKWTRTSDSKVKGSIEVYSRDLTGIPAKRQSEVVFPAGTEEEAAASLHLTRGELFGEVDTPGRDPNDVFQLSIESLRMVARNALQIMKLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCN1</accession>
    <name>A0A2I2GCN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator complex subunit 27-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_355586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705933.1">
        <property type="nucleotide sequence ID" value="XM_024844098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCN1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCN1"/>
    <dbReference type="GeneID" id="36551798"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355586"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36985" checksum="5E7115E8386F215A" modified="2018-02-28" version="1">MSNPVNLVGDATSAARPPPQTLAETKENVAAVLVDNGASSAEISESEMQLVSSLAKLQKLEAMVHQLRTLLPDRLLEPMRPALNPKAAPGSVAGSPEIMLQQASHIFRGGVAEVQEFQSMWRGPEMKAVWERVDAQIKENGGNLLQPTGVWEQDYDTILEELVKEQEKKNEKQRKADEEQERSNIRSTEGGWRAIVDGFAQRNVPGMRLIPSKREASVTVALAKAGMVFNVHTVGGTEGNGVPEWQVSSKTAPGQSQTKVERSITDCLNARPQQWNLAHLLDMISSYSSIKQTPCMKCGKMTDAATQLPTIRQHKLTPSPTDGQPPSSTWEAYHASCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDG4</accession>
    <name>A0A2I2GDG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_425197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706202.1">
        <property type="nucleotide sequence ID" value="XM_024847611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDG4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDG4"/>
    <dbReference type="GeneID" id="36555310"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425197"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="138" mass="15391" checksum="C14F612DEF4F93E3" modified="2018-02-28" version="1">MASKKTVLIAGCSDDDIGSGLALTFRQRDYHVFATARNSQKMAKLRDLPNITWLTLDVCIKNHITEAVETVREHTGGKLDYLVNNAARNHFMPAFDEDLETRKKLYDTNVWGPIAVVQAFAPLLIRARGTIAFITSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDI0</accession>
    <name>A0A2I2GDI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_446129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706250.1">
        <property type="nucleotide sequence ID" value="XM_024850769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDI0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDI0"/>
    <dbReference type="GeneID" id="36558468"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446129"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014147606" evidence="2">
        <location>
            <begin position="16"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="187"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="542" mass="62071" checksum="91B36EAB30977227" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDS4</accession>
    <name>A0A2I2GDS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_157409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706269.1">
        <property type="nucleotide sequence ID" value="XM_024842547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDS4"/>
    <dbReference type="GeneID" id="36550244"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_157409"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014128254" evidence="1">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="158" mass="17573" checksum="7612F08F26DF57AF" modified="2018-02-28" version="1">MSIILLLCATVTVHCHIIVAFKLQNKQWFGNTARPSNRMVQKATRSCSSAAMDLCAWLGNCLPIQTALDHAPVGMLLVEGFCLYLHSQLWSSAEELGLVGQDSCYCCQQITCSMARERYSVESQTKERTSQILHHLGVSALREMPVTLASVLKDNFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE71</accession>
    <name>A0A2I2GE71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_406883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706486.1">
        <property type="nucleotide sequence ID" value="XM_024846650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE71"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE71"/>
    <dbReference type="GeneID" id="36554349"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406883"/>
    <dbReference type="OrthoDB" id="4360026at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="416" mass="47750" checksum="E97CB574FCEA4CD1" modified="2018-02-28" version="1">MAALTKRPWFKGIKKQFYDEEDCLLATRGQKIPQGLALTINQLCVVRGIRYHPGFATELYGVRPQFTRALNARSIMSNAIPEMTEPEDFPYCIWYPETATEATYRELVARYPQMKYLVGRACAVAGYYKLFKELDLLPESHIAEEARDNKQWAIFDDIMAENVRFNAMDDYTRTVYEKPVVGYMNGDTAVRSYLEVKTKFKKPADERNFEAGRRSSYFDITEDDRPEHDGLRIDMAINARFIMNNDLSRITPECRSLPYCIWYPAIPKQSTCRELVRRAPSMKPSISMVCILADYSDLWDQIDPDPDTNLMEAARECHNPKYLSDLESKVGERGCTDYAFDMFCTSVPRVRMFEPSQTSVLPDIRGIVPDDDGVPYNGYQVGMAHVELFVTVSDDFKSGNGTDLNRYYDSLAPNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE81</accession>
    <name>A0A2I2GE81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRAPP complex protein TRS85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_406925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706511.1">
        <property type="nucleotide sequence ID" value="XM_024846657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE81"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE81"/>
    <dbReference type="GeneID" id="36554356"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406925"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="81622" checksum="722C0F976AA74E62" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFQ7</accession>
    <name>A0A2I2GFQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706993.1">
        <property type="nucleotide sequence ID" value="XM_024848522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFQ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFQ7"/>
    <dbReference type="GeneID" id="36556221"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433563"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="327" mass="37284" checksum="0AF51D87FF6D43BF" modified="2018-02-28" version="1">MVPLPSLSPEEYAEHLSAFLDEIQFSMPQPNPDLSIDKMVISHFEAQPWDPVLINKATRKAARSAEMMRMVYPYVDSEINIAYGIFCTYMFVIDDSDEALDAELASFEGTLFEEKSQQSPFLQSLFAFLNDLGSHFGPFSRTMIFKSMIEFITGRLIETRYKEMQPPSAAVKFPYYLRQKTGVAEPFAHFMFPEKMYPENECLALYILILPDLCDIISFVNDIFSFYKESILSSEVNYLSNVAMVQGIHVSESLKRTSKEAAESLKNIRAVLADHPVMLDTTIQAVWGWIASHISQARYRLFELDLHVPSVDGRILDTQKNRAAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH08</accession>
    <name>A0A2I2GH08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_377638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707429.1">
        <property type="nucleotide sequence ID" value="XM_024845410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH08"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH08"/>
    <dbReference type="GeneID" id="36553110"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_377638"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="44"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="192" mass="21936" checksum="C32DD7B39751625F" modified="2018-02-28" version="1">MTEIGEAGGQPFPNPMAGTTKEAYWKHRAPYKMQSAEEFGRVQWHGKCQCGQVRFKLNRERPLRSKYCHCRNCQLLHGAPFQWAAIFHKTDVAFVNGADGLAFYSAGDRTREYETPTKLSCSYCRTPIMDEGRNMCMVFPTTIEHGSSDREVQEWREAFAVECHIFYSARAVDMPDGKPKWSGLDGHSDQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHA1</accession>
    <name>A0A2I2GHA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_99116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707560.1">
        <property type="nucleotide sequence ID" value="XM_024855463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHA1"/>
    <dbReference type="GeneID" id="36563170"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_99116"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="465"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="705" mass="71926" checksum="C6A09A955761732A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHD7</accession>
    <name>A0A2I2GHD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_402320</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707586.1">
        <property type="nucleotide sequence ID" value="XM_024846417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHD7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHD7"/>
    <dbReference type="GeneID" id="36554116"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402320"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000004">
        <property type="entry name" value="DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB52284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="796" mass="90955" checksum="79B7490C61570796" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHM1</accession>
    <name>A0A2I2GHM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rta1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_352846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707666.1">
        <property type="nucleotide sequence ID" value="XM_024843942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHM1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHM1"/>
    <dbReference type="GeneID" id="36551642"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352846"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="52794" checksum="6EC2FB5BFD432DCD" modified="2018-02-28" version="1">MCAQKFLTDVENGVVPVNSHDQLLRIAWIYMDEPLWNGQGVFDVIEKLHTHGWSFGEGELRFNRTLDMFYLAQIAAALYLTVHRSSDPIDGLFETLDGFNTFYTEHHALLHPSVWREYYSEPFLKQKTTARFYRLPDLQDLPDSNHPLDIPIRERPHVGGSPHVTKLPRWAHNVARTYLRQPLLPLATLTDIALSTLETTIIRQRKAHPSVRPYSETQARFWLEYMVAPYLKARTRTEVPSPTRWNENGFGILAAQGFHDMYEWERKYSVQLWEASWEQKGVVEPDVEDGVWKSEIIFCGHPDGGISSYAWWRGWDGELGSEEEIEFLAAVAVEETVGVEHLDKLDFAVRSHILLGVMRAAVKTGREREDLLQELEMGMVQSGRIKERARLWLREALGVVKPYVRLWEGVWPDAKERRKMLQQILVENGQLLARWKASPHLKEFSFELGPPVYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI52</accession>
    <name>A0A2I2GI52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707864.1">
        <property type="nucleotide sequence ID" value="XM_024848679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI52"/>
    <dbReference type="GeneID" id="36556378"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434282"/>
    <dbReference type="OrthoDB" id="4338083at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014176768" evidence="1">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="132" mass="14541" checksum="886FF17BD3B84AC1" modified="2018-02-28" version="1">MHIPTLLTALTSTLALSAEFQVLKPRNWDLHLLSPGCSPNSSNFDVSLYHRSGVAARSCVSLTDDGATLDTGKIDSISWKSPIEKHYDLCTFKDASCSKEGFVGAVRSDWAVCYPYQGWMAWKVVGFGEECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI54</accession>
    <name>A0A2I2GI54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_378453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707861.1">
        <property type="nucleotide sequence ID" value="XM_024845448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI54"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI54"/>
    <dbReference type="GeneID" id="36553147"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378453"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="57" mass="6543" checksum="8D8020FF20471984" modified="2018-02-28" version="1">MFSCWCIPVGLFIFAWSSYPRVHWLGPAMGGFPIGYGFIFLYNSANNYLGEFSHLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIS0</accession>
    <name>A0A2I2GIS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_350653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708071.1">
        <property type="nucleotide sequence ID" value="XM_024843817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIS0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIS0"/>
    <dbReference type="GeneID" id="36551517"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350653"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000342">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014188040" evidence="1">
        <location>
            <begin position="16"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="182"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="702" mass="77288" checksum="040E6BEF76C7541C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJB8</accession>
    <name>A0A2I2GJB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_119378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708272.1">
        <property type="nucleotide sequence ID" value="XM_024842353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJB8"/>
    <dbReference type="GeneID" id="36550048"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_119378"/>
    <dbReference type="OrthoDB" id="4507572at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023:SF1">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="62797" checksum="6E6BE9AEE3550792" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJI6</accession>
    <name>A0A2I2GJI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_121859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708338.1">
        <property type="nucleotide sequence ID" value="XM_024842363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJI6"/>
    <dbReference type="GeneID" id="36550058"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_121859"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014131047" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15278" checksum="6374A170EB167054" modified="2018-02-28" version="1">MQSWQLTGAHVHLFSFPFFFFTPSRGLLTSVYDTWYSVLKFPLWPQPVFPCYATRLVLKLMTAEIKGMREFCDRPFWLIRTPRIPGRQCIPVTSTTNRRRIMLVAWPGWVRRELCELGPAAPSRNNERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJI9</accession>
    <name>A0A2I2GJI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar iron transporter Ccc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_403787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708336.1">
        <property type="nucleotide sequence ID" value="XM_024846494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJI9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJI9"/>
    <dbReference type="GeneID" id="36554193"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403787"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="291" mass="30826" checksum="3FF99EABD2BA2A58" modified="2018-02-28" version="1">MSISSLKGLLSSYSPISEYSPDLEKEYQLPLQHDSSDVESSSGQSKSSLSEKKESRFFDGRTVSDAIIGLSDGMTVPFALTAGLSALGDTKVVVFGGLAELIAGAISMGLGGYLGAKSEEQSYHATYKETETETMTNPSSTSDTIADIFAPYDLPPHLVSELTTHLSTSPMLPSFLMNFHHTMPEPSGSRAFVCALTIALGYFIGGFVPLVPYFFVGPTEAFVALRWSIATMVVALFVFGYGKTCFVSGWKGKRNVRGGMVGGVQMVLVGGIAAGSAMGLVKGFQMLATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL60</accession>
    <name>A0A2I2GL60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_343728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708917.1">
        <property type="nucleotide sequence ID" value="XM_024843418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL60"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL60"/>
    <dbReference type="GeneID" id="36551118"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343728"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="361" mass="39647" checksum="ED9A42475F14C2E3" modified="2018-02-28" version="1">MASIPETMWAAHISQFDQPYTITRVPVPRIRPNELLVKIEAAGYCHSDAQVLHGEMQSALPMIPSHEPVGVVVAAGDAADGWTVGDRVGILNFKNACDQCAGCRATHRRWRRLDARFCERRETSGFHHDGAFAEYMAADAATTVALPDSVSFEQGAPLLCAGATVWGALMKARPFLQPGDTVGILGIGGLGQLGVQFARALGYRAVAIDNRDESLQLTRQAPASLQPDLLVNSSHDDARDHIFRHTDHEGLAAVINCVDSLAVNAWSLELLRVGGVAVLLGLPAQRWQFDSYLLVFRELVIRSCYVAGRDEVEEMMQTVHRHGIRSQLTVVGCQEISGVPERYQTKAFRGRLVVRMEGEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLJ8</accession>
    <name>A0A2I2GLJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_4260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709062.1">
        <property type="nucleotide sequence ID" value="XM_024847682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLJ8"/>
    <dbReference type="GeneID" id="36555381"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_4260"/>
    <dbReference type="OrthoDB" id="4506360at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="132" mass="13901" checksum="42F09CBFA332C235" modified="2018-02-28" version="1">MLLPLTSEKSIRSTMAHQVVSTVRLDPEHNSCIGGRTVLTCRHCAGNAPSSCSGRGFNIFVCAHCNPAAAAQASTPDSSTPNSPASLSRSSSTSLSPKRDLRHNQPWKRFEDGNDGPGGGRVGTNTNRPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLL9</accession>
    <name>A0A2I2GLL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_420582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709074.1">
        <property type="nucleotide sequence ID" value="XM_024847302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLL9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLL9"/>
    <dbReference type="GeneID" id="36555001"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420582"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="331" mass="37196" checksum="E285E556143156F6" modified="2018-02-28" version="1">MKFLPLPEIEDVTSSLNFDTADCHILGGCDLYTTKAARADRKLYKNIEQSLEAQYESVLRLSASLSPPNASDAAASLNLSRSSPFGPLSEHSSRRTFAYLIATLNASHPDYDFSHVLRPSDFHRERNLKRVMNTIDTTLFNLRPREAIDLTPPSPVTISGSYNAGASSTWGPRLWKIIDSQMSLKECSLYSYSPEEDPSDADDGAIWSLHYFFFNRLRKRVCYIYLRAIPILSHTPSEGVASTPTKRTFDDGYLTPELGSSKRARYWLGDRADLEEQESESDEGDSTLQPSRPVVDEYDNYLLSDEEFRSRSGSKGTVRAMSEEIADAMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLS8</accession>
    <name>A0A2I2GLS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_431627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709129.1">
        <property type="nucleotide sequence ID" value="XM_024848078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLS8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLS8"/>
    <dbReference type="GeneID" id="36555777"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431627"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014146231" evidence="4">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="294" mass="31015" checksum="0905DD7192F2BBEB" modified="2018-02-28" version="1">MPQGRIWFITGASSGLGLQLALTASQHGDTVIATSRDPSKLAPLAEQNPLIIPKPLDPATASPDTLTTLIDEITTAHGPIDILVNNAGYILEGAIEECTDAELEAQFAVNVFSPVRVIRAVAPSMRARSAGIIANIGSIGGWNGSPSAGFYCASKAAVGVYTEALKAELAPFGVDVTCIEPGYFRTGFLTSGHKVSAGKRIPELDVATRGMREALEAYSLKQPGDPVKGAQVMYEALTKTGRFEVLREEGRHLPARLALGKDALDAIGGSLQREREMLDTWGGVVGETDCADVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLU4</accession>
    <name>A0A2I2GLU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_344609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709150.1">
        <property type="nucleotide sequence ID" value="XM_024843475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLU4"/>
    <dbReference type="GeneID" id="36551175"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344609"/>
    <dbReference type="OrthoDB" id="4227485at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="118" mass="14281" checksum="1797D583D282F9D6" modified="2018-02-28" version="1">MAEESSYFHRYARIKLRCLKFEYSYFRKKILNLLYLKVLQEKFKTNSYTYKEPQNFIIAIVTDDLLERIIAQSDLSLDTLKDNTNLLWLTVPKDIQILYLYRKYQVETTKYSLLPGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLX4</accession>
    <name>A0A2I2GLX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_431659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709193.1">
        <property type="nucleotide sequence ID" value="XM_024848089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLX4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLX4"/>
    <dbReference type="GeneID" id="36555788"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431659"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="346" mass="37391" checksum="EC0178F00FADC1FD" modified="2018-02-28" version="1">MPPVQVIATEDEKETPLPASTSDQYGGNQKSGMLSMCPPALVPYVQLARLFPPAGLFLIYFPHAFGILHAAVRTEASLSAVLQASAVLFAGSFFFSNAAHIWNDLIDAGLDAQVERTSRRPIPRGAISPTAAFLFAASQGIAAAWFLAYLPQGFPVAFCYALPNILATMYYPLSKRHTHFPQLVLGFCLAWGTVIGELAMGAPPFVYSASQGFSIDYSVLCLFLAGVAWTIIYDTVYAHQDLQADLQVGIKSLAVLFQARTKALLWPLLATMAALLIECGLLSAMSPLYYLVTVVGATLSLATMIARVDLASSPSCWWWFSKGFWWAGGAICVGLLLEYVVLSISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM93</accession>
    <name>A0A2I2GM93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_460274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709304.1">
        <property type="nucleotide sequence ID" value="XM_024851926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM93"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM93"/>
    <dbReference type="GeneID" id="36559624"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460274"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="109"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="493" mass="55391" checksum="89E7A263C1ABD8D8" modified="2018-02-28" version="1">MHSNADLADQERVLHSTAIEHHISRRGAVNFAHRDVWGPREKAMGDPWSPNNPNGTVILRLAENSLMHEEVGDYICAQVVLHLKLQAESLIPSIQTKVLPVDHLTYSTGPRGSRRLRRAAAALLTEQFHARSLITYDNILVTPGVASAIDGIAFAICDEGDGVLVLQPLYNGFKFDMQNRANVQIVGVKFEGVEGFGGLDDLFRPEVNRKALEIALQQARKAGINIRALLISNPHNPLGRCYPPETLKEFASFCGQHNMHLISDEIYAFSVFANPEIPSAPNFTSILTLDLDKIIDPSHKHVLYGASKDFCANGLRLGFIFTKNEGIIGAMSSIGIFSWLPHLLQDAWAAMLEDKQWMERFMEQKRQLMLDRYEMTTAFLSKHDIPYYEMNAGLFIWVDLRHLLVARSQEPDRGALVRSSPDAQLSLQLELRFTEICMENGVMIAPGHVYMSESYGWFRITFTVGKKALEEGLRRFLASIKKMKAECQLSKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN74</accession>
    <name>A0A2I2GN74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_452122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709643.1">
        <property type="nucleotide sequence ID" value="XM_024851247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN74"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN74"/>
    <dbReference type="GeneID" id="36558946"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452122"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="743" mass="83101" checksum="0560C5E87214C988" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN75</accession>
    <name>A0A2I2GN75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709640.1">
        <property type="nucleotide sequence ID" value="XM_024848160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN75"/>
    <dbReference type="GeneID" id="36555859"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431969"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="55" mass="6412" checksum="0D5B28ABA69327D7" modified="2018-02-28" version="1">MHNIAQTSDERGQDKSMNGTKLKMMSRRRFCATTIQSPGNRIQKWLSINERRVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPB7</accession>
    <name>A0A2I2GPB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_344825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710021.1">
        <property type="nucleotide sequence ID" value="XM_024843486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPB7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPB7"/>
    <dbReference type="GeneID" id="36551186"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344825"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="496" mass="53897" checksum="C90FC639FC236F30" modified="2018-02-28" version="1">MIKNLDDEILHLQGHDASMPRSFSSVASIGLAFSITGSWVGYLSCFGASITFAGPQNVVLGLVVGTVVQWIITLGLAEIASAFPSSGGQYHAVFCMASEGTRRSVSYLTGWFSMLAWWINTSSGLMIAAKAVLGLASFCWPTYDTVNWHVYLVYLLVMLVTAAPLTMSRTVPWITQGCLYISVSGFLMAFIVVMAMHQEFQPQGYLLHASHGTSGWPHGFAWILGAANSMYAYVGTDGAIHIAEEMNHPGRRIPQIMNLTMLIGVLSALPLFMALIYAIQDPEKVASATLPSLELFYQATGSRAVSLFLQIWVTTVYISSMTSQWVTSGRMAWAFARDGGIPFSDYFAVVDERFQSPIRATVLSTAFASLYGLLYLASTNAFSSITTSAVLYFNISYAIPQAMALFRGRAVLPRRSLNLGPIVGPFCNAFTVIAVLALVIIYSCPSTLPTQVDSMNYSSVVLVGISGIILASWLLVGSRFRGPDVDLQRMHFLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPX9</accession>
    <name>A0A2I2GPX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_26906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710231.1">
        <property type="nucleotide sequence ID" value="XM_024843129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPX9"/>
    <dbReference type="GeneID" id="36550828"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_26906"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="91" mass="9989" checksum="E8BD762ECFAA79F4" modified="2018-02-28" version="1">MTSPRPPPGCPCDARGLRAPRPSHAPKPTYRPARTNRSSPFGASLQGEPNRREGGGADCFSLLRRVTSPGHYLLSLCRLASSRAIRRKHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQB8</accession>
    <name>A0A2I2GQB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_461014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710363.1">
        <property type="nucleotide sequence ID" value="XM_024851991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQB8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQB8"/>
    <dbReference type="GeneID" id="36559689"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461014"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="369"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="706"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="816" mass="90737" checksum="209F0DE3EB4A1667" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR86</accession>
    <name>A0A2I2GR86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">DNA repair protein REV1</fullName>
            <ecNumber evidence="14">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_461263</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710675.1">
        <property type="nucleotide sequence ID" value="XM_024852020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR86"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR86"/>
    <dbReference type="GeneID" id="36559718"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461263"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 14" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="367"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="192"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="738"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="886"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1110"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="916"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="949"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1110"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB55373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1158" mass="127013" checksum="F3ACECD4C4794B05" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRZ9</accession>
    <name>A0A2I2GRZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_375538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710944.1">
        <property type="nucleotide sequence ID" value="XM_024845322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRZ9"/>
    <dbReference type="GeneID" id="36553022"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_375538"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="351" mass="39796" checksum="0CEE16B865C485F9" modified="2018-02-28" version="1">MDTSQETVGNVQRFTEKREKVEDFYEKNQPSDPDFREYNRRIESTLKDLQDQVKRQENDLQKLREVNSIDLSKMGHDPWARVSQVRRAKEAYNSLLKSRTDLPHPGSPLPALLAIGETSRLINETKVSVSMTAEKISSDRQRLKVEESNLRDAQAIRDGLEKRLEKIRNEKSQKQKRTPSQLAQEFLDEQQQKTEKLGSETEELKVSLHGFIDEHLAPMLAAENLGGPTTGDTMGISDDTLERGYTNHGKPKKPRPVETTEGDGTQRRIDEMVRSAGQGGTERRNTSNKRETAAAEMNGLLDALLDAGSSYIDLPRESAASRFLVRAKVAQFHPRDARKLRLIDFGRSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS96</accession>
    <name>A0A2I2GS96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_443469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711049.1">
        <property type="nucleotide sequence ID" value="XM_024850548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS96"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS96"/>
    <dbReference type="GeneID" id="36558247"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443469"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF12">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE IVOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="224"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="743" mass="80823" checksum="AB86D836B80FBB1B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSR5</accession>
    <name>A0A2I2GSR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_52778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711220.1">
        <property type="nucleotide sequence ID" value="XM_024855253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSR5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSR5"/>
    <dbReference type="GeneID" id="36562959"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_52778"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="244"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="407" mass="43701" checksum="8D560E2EAD4F99BC" modified="2018-02-28" version="1">MSAHYNANNSRAHRRMSGAQHGDPGRAGHDTSFMAPSAIDPSRVVPRSPYGYPGDPGPTAYGDSRALYQQNISPYSTQPGVSTSASLYQPTPQSSVNYPQGNYTLRSSQQASPAQIGHSGEIPNPYVHQPASSITRGTSYEHRSSFSQPSGIDGLTDGIRNLATSSTGTQWSSSPGAGDPGHAPGISHVRCSGGATIKASSNCPVQSVQSLSRGSGMPHNVISGTSSTHNTTLDPRYVVQKSPRNFFKVGRVFAILWHENEGSTGRGTQSYISEGPVYTGRFNELVHSGIRRMVVVKALDQCAWCFPVGTYSRKGVAKAGVDASKHAVIYMQGTEPQLGSGEPRMTKGPLEVAPASPDQKLDHMSRLNFGKIYTVEHNVKVLPVGKITERSMPRFQSYARNEINIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQM5</accession>
    <name>A0A2I2FQM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_451505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451505"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="98" mass="10590" checksum="103B773BD7711620" modified="2018-02-28" version="1">MDGAHSVHSGTLTSRSSFAPIPKFDDRFARQNRCEPPPEFPLASPYSGIVHHLSGPHIYALTQIHPKTSGSVDGAPREGAPTSVRFHCAHGFDTRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR41</accession>
    <name>A0A2I2FR41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_71795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698406.1">
        <property type="nucleotide sequence ID" value="XM_024855348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR41"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR41"/>
    <dbReference type="GeneID" id="36563054"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_71795"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000969">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1136" mass="126196" checksum="364DC8DC615D3D3F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRC7</accession>
    <name>A0A2I2FRC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_369818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698496.1">
        <property type="nucleotide sequence ID" value="XM_024844930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRC7"/>
    <dbReference type="GeneID" id="36552630"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369818"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26964" checksum="C4DB443770817D4B" modified="2018-02-28" version="1">MADFSFRGQSLDNDLVGSISSLLNDAGIPNLLWGNYLLTIYGVPTIVDGVSFIVPDALIEPGLSTLLHSGFLPCTPSFECPHSNDAKGFSTNAHLHINEELVISLYGKSDMLWELPDFDIATQNTDIMSASDPQLPPTILGRGQGRFPSHLSAVRIPSAVRYCEAILFLLCRDYGHLREYYWMAMLTYLMEYVDGTDILREESLREEYTPFYGAIIQGDPDMWLHLDTLRDGLIRRQAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRK0</accession>
    <name>A0A2I2FRK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_394775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698566.1">
        <property type="nucleotide sequence ID" value="XM_024846070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRK0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRK0"/>
    <dbReference type="GeneID" id="36553769"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394775"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000057">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="171"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="348" mass="39478" checksum="A0AA1A2F0AB33345" modified="2018-02-28" version="1">MDRDFSAIPVVDWQRLQDPGTKPHALAQLRDAIFQVGFLYLTNHGLEDLIRRAHAQLPELFDLPDKVKERCNMLNSPSFVGYTRLGAETTASKTDWREQYDFGTPGMKRWTPQDPFWQRLEGDSQYPDHPGAKDLVEEYIRESASLSRRFMRAVSECLSLPLTTFESFKGNMDRLKFIKYPPAAPGSQGVGPHKDSTGLFTFLSQDDTGGLQVLNKKGEWIDAPPIKGSLVVNIQQGFEAITGGICTATTHRVMAPVNTTRYSIPFFLGVRMDLTLAELKESAKHIVERIPASDDRKKRAVDVPSEFLSPLYSCFGEAYLRNRILSHPDVGQKWYPELYQRYSTEILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRK8</accession>
    <name>A0A2I2FRK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_370083</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698549.1">
        <property type="nucleotide sequence ID" value="XM_024844941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRK8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRK8"/>
    <dbReference type="GeneID" id="36552641"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370083"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000056">
        <property type="entry name" value="CCR4-NOT core complex subunit Caf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB43247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="491" mass="52760" checksum="CB42683272EAE5FA" modified="2018-02-28" version="1">MPPPVGRYGPTGLSAPYTHLQQAHLQQQQPQHHPAHAQSANTALPPPSLGGHPGFAAGNPNTNINPFTLSGTGIASGMSVGGFGADGGGTGLASHAAQMGFARGAQMQQQQLHQAHDGRLALETKGGGVKTRIRDVWKHNLAQEMAILRQLVEKYPYISMDTEFPGIVARPIGAFTNKADYHYQTLRCNVDLLKMIQLGITLFSPEGEVPPPNATDANGQPMGNSLVPAPCTWQFNFRFSLEEDMYAQESTAMLAKAGIDFAMHDKNGIDPHDFGALLISSGLVLLDEVHWVSFHSGYDFGYLMKIMLCASLPENEEEFHKLLNTFFPSLYDIKYLMKHAGRNQAVNDSPLTAAAVQILANLGQKSGLQDIADELGVKRVGIAHQAGSDSLVTGEIYWKMRQLVFNGTIDESKYSGQIWGLNGQMPLMQYSMQPHQTPNLNGATIYSSTGTPSTPNAAQSVGNQTPQHHGLGTLTPGAVGGVLGQFAIGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRN4</accession>
    <name>A0A2I2FRN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_394782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698568.1">
        <property type="nucleotide sequence ID" value="XM_024846071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRN4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRN4"/>
    <dbReference type="GeneID" id="36553770"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394782"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="481" mass="53680" checksum="E349999428323529" modified="2018-02-28" version="1">MSAVEMNVAEIPPQSGKDWYDFPTECERSLTSIMAPRNIVIVGAGIAGIACALSLSKELTPFVPDLQITIFERHDILSTSGGAINLTPVAQRHLDQLGVLAELDRLGAEGGSDVDAIEIFSSRSGRQLGSIDFIDHGGNGFGGYKGRRVMRIILSVAMLAMVERTKNVNVVFGKKLVRGEESEDKATLHFSDGSSATADLVLGCDGVHSATRQQWIDPASTSEYTGISFVQSVIDTESVNAPIHFRSTAMNISRHGSLITSYCDREHEQIFLAAIVQVNEDLLAHYRLEPGQDIRKQTAIKRALRDEMKHRFGKSAVPCIREMASKSADWMLYPVYQVKPGSKWHTDRVMLLGDAAHAMPPRDESAAYALDDAILFSRILAKHRHEPLSAAFRAYEDLRRETVNTAFKSSRRMWEKHRDMSFLEGRLKEWTLPFYLKNSKEAREAAWEFDATKISIPMPVEEQSSSSSYSYEKEFSVARCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRQ0</accession>
    <name>A0A2I2FRQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_481257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698612.1">
        <property type="nucleotide sequence ID" value="XM_024853849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRQ0"/>
    <dbReference type="GeneID" id="36561547"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_481257"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="57" mass="6396" checksum="5628EB4611F8EC49" modified="2018-02-28" version="1">MPLSDSLQPPLTPAERAIVKSYGGWTMFLLSYGLKPWNEDENEEGKRIVEALAEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSF6</accession>
    <name>A0A2I2FSF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_56325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698865.1">
        <property type="nucleotide sequence ID" value="XM_024855275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSF6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSF6"/>
    <dbReference type="GeneID" id="36562981"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_56325"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="179"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="221"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB43563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="373" mass="43047" checksum="65411B70AEF4B21B" modified="2018-02-28" version="1">MGSCMSSESSEYSEQRKKSQAIDRKLDEDSRKLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTVEELALYRLTVYKNLMDCVKSLIGAYHQFSLEPSSQKVRDYIQFLSDYNIDPDPNTALDPKVGDAITYIWSDPCTSVALEHQNEFYLMDSAPYFFEEAKRIASPDYIPNVNDVLRARTKTTGIYETRFSMGQLSIQYVEFLSTRHLDAYKFGSMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESNQNRMMESLVLFDSVVNSRWFMRTSIILFLNKVDLFRQKLPRSPLSTYFPDYSGGNDVNRAAKYLLWRFNQVNRAHLNLYPHLTQATDTTNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSL9</accession>
    <name>A0A2I2FSL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Low temperature requirement protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_393489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698932.1">
        <property type="nucleotide sequence ID" value="XM_024846024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSL9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSL9"/>
    <dbReference type="GeneID" id="36553723"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393489"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50460" checksum="8A03B5F466C340E6" modified="2018-02-28" version="1">MSGVSGIDAQPNPRYLFRQPVALQWFENGKLVKRQEEERQAGRFELFLDLLFVAILANFAESLAEDITGARLAMYILILAPSWHVWSDLRELMNSFYNDDLLQRVLILWVMAVLVVYGNNATLVDKDLGAMRATVAAYMVARLSCNAAHLFYSFASYHHRAQQRLWCLLATLALCIYIPLYVKSVSIRGKIAAAAVGIVVEQCVWIFCYSPAAKRVLKARYTTAVDIAHEIDRFAAFYIIVLGEFLYQIVVGSPAAIGLNLGLLRAVWTLVIAFCLNWLYVHNDGALDGTHPMRHSVYTAFSWITLHLPLSGSLLASGHVAAASAAEDRFGDAERWLLCGSLGTGMFCLYGLALLFESKDAPGTLILGKHFRVIMRPITGLIIVLLGLADSLDITAMMSILMALVAFCLIWENVTSLRRDAKIWERWENTEYPEERDDVVPIIGEGSGNSENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT78</accession>
    <name>A0A2I2FT78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_418246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699160.1">
        <property type="nucleotide sequence ID" value="XM_024847209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT78"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT78"/>
    <dbReference type="GeneID" id="36554908"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418246"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="410"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB43858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="520" mass="56300" checksum="F1CAA85157A4C760" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTM6</accession>
    <name>A0A2I2FTM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_67067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699295.1">
        <property type="nucleotide sequence ID" value="XM_024855331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTM6"/>
    <dbReference type="GeneID" id="36563037"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_67067"/>
    <dbReference type="OrthoDB" id="4366200at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="665" mass="72812" checksum="BF90E84363183D09" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTQ5</accession>
    <name>A0A2I2FTQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_68333</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699325.1">
        <property type="nucleotide sequence ID" value="XM_024855337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTQ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTQ5"/>
    <dbReference type="GeneID" id="36563043"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_68333"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="159"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB44023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="470" mass="51169" checksum="F226B9D5FFB4EA42" modified="2018-02-28" version="1">MSSPSSAGKRKRSASQHLPAHATKPSPADLLQPSSRDASGEEGDESTAPATPSSSKPKQHAPVDVTSVPPSKRARKSSVGDSSINGPTAEEPSGISKEDPGEPSETTVASSDIENQRHGRPGLQLQTRQNLEPPEKAGLQDPVGYSTNPPPTGRPVRVYADGVFDLFHMGHMRQLEQAKKAFGDVHLMVGVTGDDETHLRKGLTVLSGAERAETVRHCKWVDEVIPNCPWIVTPEFIDQHQIDYVAHDDLPYGAAEGDDIYAPIKAQGKFLVTQRTEGVSTTGIITRIVRDYDQYISRQFKRGASRQELNVSWLKKNELEIKRHVTEIRDNIRTNWSTTGQELGRELRQLWQNSRPGSPAPSARNSVDLGSTRGGLVSPTTGAKSHLSRVETLGRPDSPVGNGRNEDFATGYSLGLIGGVRAWMRSRRSLVESRAHSPTSEEEHDSEQERSNGHVGNSTEAPANARVHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUJ6</accession>
    <name>A0A2I2FUJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_450447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699596.1">
        <property type="nucleotide sequence ID" value="XM_024851125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUJ6"/>
    <dbReference type="GeneID" id="36558824"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450447"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="869"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="968"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117390" checksum="CDCCBB71E4E525CF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUQ3</accession>
    <name>A0A2I2FUQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspergillopepsin-1</fullName>
            <ecNumber evidence="4">3.4.23.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspergillopepsin I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Aspergillopeptidase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_367476</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity. Generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk.</text>
            <dbReference type="EC" id="3.4.23.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.18" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699598.1">
        <property type="nucleotide sequence ID" value="XM_024844808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUQ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUQ3"/>
    <dbReference type="GeneID" id="36552508"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367476"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014199214" description="Aspergillopepsin-1" evidence="14">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="86"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB44296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="395" mass="41631" checksum="D0B06E57CBEC4D96" modified="2018-02-28" version="1">MVVFSKITTMALGLSSVASALPHAQPRKGFTVNQLTRQTANPKSINIPAQYAKFLAKYGATIPQSVKDAAAKGTVVTKPEEYDSEYLTPVEIGGTTLNLDFDTGSADLWVFSSELSSSEQSGHSVYKPSSSATKLSGSSWDISYGDGSSASGDVYKDTVTVGGVTAKSQAVEAASTISSEFTQDKNNDGLLGLAFSSINTVEPKAQTTFFDTVKSQLDSPLFAVALKYHAAGSYDFGFIDDSKYSGEITYADVDTSQGFWQFTADGYAVGDGATKSDSISAIADTGTTLILIDDSIVSAYYKQVDGAKEDYSAGGYVFPCSTDLPTFTVVIGDYKAVVPGKHINYAPVTENGETCFGGIQSNSGLGLSILGDVFLKSQYAVFDSEGPRIGFAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV32</accession>
    <name>A0A2I2FV32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_513672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699802.1">
        <property type="nucleotide sequence ID" value="XM_024855135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV32"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV32"/>
    <dbReference type="GeneID" id="36562841"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513672"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="362" mass="40078" checksum="40B698A5E09CCBA5" modified="2018-02-28" version="1">MDVQALYHMLRLEVLHPKLFTFARDGPLPLMWNNLTTRSKALQPSELDALTGRTALIAGATSGCGLQLAKILAAHCTRLIITARDPQRGQQAVEEIRNSLSSDTSIKSQIEVWPLEMASFQSVRDFTERVNLLPSLDIAVLNAGIWHLHFARSTDSFETHLQVNYLSSCGLSLSLLTALGRNRSPASPPGRLLNVTSEGHALEDIPAHKSANEVLESFNDPDKLTCYTRYRLSKLLSMIWTHELASSIDNVAHNVEIASFTPGASQTQICRDLGTGPIVRVAMGAFCQSAEEGSWGYVRALGAREFHGRYFFRETACQPTDCVTAEKYKAFREDLMRQTLAVLGKHIEVPADINDWLGDISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVF4</accession>
    <name>A0A2I2FVF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_289602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699930.1">
        <property type="nucleotide sequence ID" value="XM_024843235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVF4"/>
    <dbReference type="GeneID" id="36550935"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_289602"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="101" mass="11523" checksum="19B6A26DB2E7403C" modified="2018-02-28" version="1">MNMRRMKRWHEGSTGHDPRRSIGRPAHSIPKCPPSVEGAHCALSAFPLGNPCGRFILVGRRIHGGTKTPRCFPRIGRWAATDVRREESQKWSRTRLVEPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX94</accession>
    <name>A0A2I2FX94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_513284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700556.1">
        <property type="nucleotide sequence ID" value="XM_024855090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX94"/>
    <dbReference type="GeneID" id="36562796"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513284"/>
    <dbReference type="OrthoDB" id="4505683at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014162907" description="CFEM domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="10">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="76" mass="7759" checksum="7D93E7D09CA514E1" modified="2018-02-28" version="1">MKVSILLPLTVLISFAAAAESGSCLQNCLTKAGSATGCKDISCACSDAQFKSQVQNCASSCPAGDKDAAKKLQQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXL0</accession>
    <name>A0A2I2FXL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">P170DRAFT_439135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXL0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439135"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="259" mass="28745" checksum="7543DEB4BE17FCDB" modified="2018-02-28" version="1">MAPITEEVVTGLKDTIGKLEARIEDLEGRLTNGNKPKSVAEQMRIILMGPPGAGKGTQAPRLKEKYCACHLATGDMLRSQVAKKTDLGKEAKKIMDQGGLVSDEIMVNMIKSELDNNAECKNGFILDGFPRTVAQAERLDDMLAIRQQKLQHAVELQIDDALLVARITGRLVHPASGRSYHKIFNPPKDEMKDDVTGEPLIQRSDDNADTLKKRLGTYHSQTTPVVEYYKKTGIWRGIDASQEPGQVWKSLLGVFHQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXL9</accession>
    <name>A0A2I2FXL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SNARE complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_512081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700682.1">
        <property type="nucleotide sequence ID" value="XM_024854955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXL9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXL9"/>
    <dbReference type="GeneID" id="36562661"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512081"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18505" checksum="E89EFD07F6320701" modified="2018-02-28" version="1">MASRFPRSNLHQRDPRAASSLFDSYGGNSRPASRSPGQVGGYGYGGYPGPGGDGSSNGGATAGGYRSATPNAKGQYSDAVLSHLESQNDVEVEGISAKVKMLKDITLAIGDEIRDTSTISELNDSFDNTRLRIRGNMNRMLRMAERTGVGWRVWLGFFLAVFLLFGYVWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXN2</accession>
    <name>A0A2I2FXN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SPX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_439162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700696.1">
        <property type="nucleotide sequence ID" value="XM_024849780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXN2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXN2"/>
    <dbReference type="GeneID" id="36557479"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439162"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="784" mass="89873" checksum="D6410BA9891C8123" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYF9</accession>
    <name>A0A2I2FYF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_439405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700972.1">
        <property type="nucleotide sequence ID" value="XM_024849827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYF9"/>
    <dbReference type="GeneID" id="36557526"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439405"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="292" mass="31726" checksum="E0095B8B7959F39C" modified="2018-02-28" version="1">MDSQGYANVADVLAWRKIKSLQTTFPEILNAVSSSDKKRFALLHIPSAEVERDTPATTSTTSEDKREGEVLHEKDAITLDQNTAVPTTSAAQETATATALAVQDQNPSHFLIRATQGHSIKSVEAESLLEKISLEDKSKLPKTVVHGTFHGAWPAILKSGGLRSMNRNQVHFATGPTLDTVLSAQPEGQAQSNEPQVISGMRRDAQILIYINIEKALAAGCPFWRSENDVILSGGIASGNGDDKLVPLEFVDVVVERKRGMGKIWENGQVLQELPADLTKRNPKGNQGNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYG2</accession>
    <name>A0A2I2FYG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_466922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700976.1">
        <property type="nucleotide sequence ID" value="XM_024852448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYG2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYG2"/>
    <dbReference type="GeneID" id="36560146"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466922"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001167">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="484"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="842"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="970" mass="107889" checksum="E29FDECE9BD6C534" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYS9</accession>
    <name>A0A2I2FYS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_252514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701077.1">
        <property type="nucleotide sequence ID" value="XM_024843030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYS9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYS9"/>
    <dbReference type="GeneID" id="36550729"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_252514"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000595">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF178">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="540" mass="60111" checksum="86AD1919CC52534D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZS1</accession>
    <name>A0A2I2FZS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sec7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_261760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701434.1">
        <property type="nucleotide sequence ID" value="XM_024843079.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FZS1"/>
    <dbReference type="GeneID" id="36550778"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_261760"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="181"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1381" mass="156446" checksum="106DCDB11BE9D298" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G022</accession>
    <name>A0A2I2G022_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_512782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701540.1">
        <property type="nucleotide sequence ID" value="XM_024855024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G022"/>
    <dbReference type="STRING" id="1392250.A0A2I2G022"/>
    <dbReference type="GeneID" id="36562730"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512782"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="46049" checksum="3F39DD910E69CDDF" modified="2018-02-28" version="1">MVESISTQKLNAAIGKIDEATRGPNAKIPGIVCVAVNRNGDLILSHASGLTKLGGESPMSLGTVLWLASCTKLLTGIACMQLVEQGRLALDDAAQLDGLAPELKKRKVLTKGPGGEYTLVPQERPITLRMLMTHTSGFGYAFDDLNISDWARPIGLDDFGGRQEEVLLRPLVFQPGTAFQYGVSMDWVGLIIERVTGMSLEKYFQTYIFAPLGINDIAFRPTQDMKRRLGYMHQRAPDGSLSVTDHLLRHALVTDESDEPFCMGGCGCFGTPREYAKILSVLLNNGTCPKTQAKLLNPETIRHMFTDQIPTLPIDLNEPCPSAKPHLANPCPIIHKPGNPTNGWGLSFALSHQKSEKGRAAGSASWEGLANLYWFADRESGVAMVFAAQVLPYGDYQVVRLCEEVERLVYESRGTEARSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G082</accession>
    <name>A0A2I2G082_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_479193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701581.1">
        <property type="nucleotide sequence ID" value="XM_024853640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G082"/>
    <dbReference type="STRING" id="1392250.A0A2I2G082"/>
    <dbReference type="GeneID" id="36561338"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479193"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="82"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="436" mass="48757" checksum="A8BAED7BB0F3E83C" modified="2018-02-28" version="1">MGSIGFDKTVLDPTLLFSKRVQQYEPGAIRSLLPLEALPGMISLVAGKPNPETFPFTEISISLKGSDGHMIVLEEDQLSEALQYGLPGGNPELIKWFEELQRRVHGIGDHDGWACCIGNGSQELIHRVFQVFTDLGDPVLIETPAYPGVAGFLRADGHQLIEVRSDAEGLNPIDLEHILSTWSGKRRPRVLYTIPTGSNPTGQSCTEPRKAQILRLARQFNFMIFEDDAYGFLDFEHPSCRARSYLALESEVNGETGRVLRFDSLSKIVSSGMRLGILTGPLPAVQKVIRITENINLQPSSTTQMMALTLFNHWGHAGFLQHCERAAEFYRQRRDAFAAAAERYLQGRATWELPSAGMFFWLTLLLPPGRDSFEVLSRQGRENGILAIPGVAFLPNQRTSCQLRVSYSLLPEKQMAEACRRIAKLVDNAWRFEILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G185</accession>
    <name>A0A2I2G185_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">P170DRAFT_438353</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701944.1">
        <property type="nucleotide sequence ID" value="XM_024849584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G185"/>
    <dbReference type="STRING" id="1392250.A0A2I2G185"/>
    <dbReference type="GeneID" id="36557283"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438353"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11 24" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 24" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="14 24" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 22" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 24" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PLB46642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="189" mass="21448" checksum="3D5B12085586B59E" modified="2018-02-28" version="1">MWIINWFYDMLASLGLLNKHAKLLFLGLDNAGKTTLLHMLKNDRVALLQPTAHPTSEELAIGNNRFTTFDLGGHQQARRLWKDYFPEVSGIVFLVDAKDHERFPESKAELDALLAMEELAKVPFLVLGNKIDHPDAVSEDELRHQLGLYQTTGKGKVPLEGIRPIEVFMCSVVMRQGYGEGIRWLSQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1D4</accession>
    <name>A0A2I2G1D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_466121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701996.1">
        <property type="nucleotide sequence ID" value="XM_024852387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1D4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1D4"/>
    <dbReference type="GeneID" id="36560085"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466121"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="164" mass="18306" checksum="5001C57E3EFFC1A7" modified="2018-02-28" version="1">MAPKKETVLKLTSFRYKKEGISEKDFHDYASKSHAPKAALVQSRHGALKVVQYHTPSASKNLIAEKIPWAIRPGWEIDDHDIQVSVWVRNTETMQAIVMDPDFQSLVAGEDDICDQTRAKVTAGWEEVFVEDGQVIDADYGTYEERISAGSSSVVTQAPEGIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G210</accession>
    <name>A0A2I2G210_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar membrane PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_438620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702222.1">
        <property type="nucleotide sequence ID" value="XM_024849643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G210"/>
    <dbReference type="STRING" id="1392250.A0A2I2G210"/>
    <dbReference type="GeneID" id="36557342"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438620"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="351" mass="38138" checksum="BD38649343A83EF5" modified="2018-02-28" version="1">MSVLWTQVSGSSAAETVPLTPREAASGLLGSVSLTCWIFLLVCEKPVLSDRDKTGSSHTDTPRSFSCQVPQLIENYRNGNAEAISFLFLFVWFVGDVANLIGGVWAGLVPVIIAIAVYFCIADGVLITQCLYYKARNASPYAVNRRRSSVETPDPTTPLLGRRFSDNLPDNATGRRRSWTAQQQANSGNRDADGTLAKIVEENDTGRNAWVKNISSVLAICLIGMAGWTVAWQSGVWKPAPEENHGGVEIAAGAQLVGYFSAICYLGARLPQIYKNYCDKSCEGLSLLFFILSLIGNLTYGAGILCHSTERNYVITNVPWLIGSLGTMVEDITIFVQFRLYATVDSTAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2U7</accession>
    <name>A0A2I2G2U7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_466510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702498.1">
        <property type="nucleotide sequence ID" value="XM_024852422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2U7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2U7"/>
    <dbReference type="GeneID" id="36560120"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466510"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000078">
        <property type="entry name" value="GMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="251" mass="28030" checksum="B8944FCEAD58997F" modified="2018-02-28" version="1">MAPLRIAVLECDTPVDKINAKYDGYWGVFSSLLRASAKALDQPDRLNPETGLDITRWDVVTAQEYPKLEDVDALLLTGSKHNSFDNDPWILKLVEYTKSALQDPRIKLLGICFGHQIIGRALDVKVGRSDAGWEIAVCDMDLTDQGKKLFGRDKLRIQQMHQDIVFEYPANVVPLGSSPRCAVQGMYLPGRFVTVQGHPEFNEEIVTEVVTLRGKAGVFSKEQTEDALERAKNEHDGVAIGSVFLNFLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G301</accession>
    <name>A0A2I2G301_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparaginase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_466553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702557.1">
        <property type="nucleotide sequence ID" value="XM_024852425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G301"/>
    <dbReference type="STRING" id="1392250.A0A2I2G301"/>
    <dbReference type="GeneID" id="36560123"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466553"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="370"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="560" mass="59547" checksum="A4817EC529FD047F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G362</accession>
    <name>A0A2I2G362_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_238674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702617.1">
        <property type="nucleotide sequence ID" value="XM_024842940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G362"/>
    <dbReference type="STRING" id="1392250.A0A2I2G362"/>
    <dbReference type="GeneID" id="36550639"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_238674"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="65"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="293"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="410" mass="45563" checksum="3A1FA35B09FE80AF" modified="2018-02-28" version="1">MAQPLSSSCPSMSEIAKAPAIQLPDGTVQQSAHLPPAPPATYRSGHVNLDTFSPVNENGSFEFDRVLKTGRVNRRVKHKHAFRASWKPAYLVLRPNLLSVYKDEEATRLRASITLSEVTAVAPVRSARSSRQHVFGIFSPSKNYRFQTSSDKETDVWIQRIRAETRADEDDEAFLALSQQGNAVAVPRQRVDDTTDHSDLEMMGRASSPELGRALSSSYRSKRLDNHLDQPGNDITSYSEWSDGPTSNSSINPRPRTPVQVQTLSASAPAGQSPMSNDLGRHSEAGILRDPERVICNGYLQCLRIKGAVRQWKRLWVVLRPKSLGFYKDEQEYSAVKILPMSQVIDAAEVDPMSRSKHYCLQVIAEEKSFRLCTPDEESLAKWLGCLKSILVARKKREPLPATGPIAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G398</accession>
    <name>A0A2I2G398_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_413233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702651.1">
        <property type="nucleotide sequence ID" value="XM_024846963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G398"/>
    <dbReference type="STRING" id="1392250.A0A2I2G398"/>
    <dbReference type="GeneID" id="36554662"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413233"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="335" mass="36910" checksum="F95D0C9429D81BDB" modified="2018-02-28" version="1">MPASQQSENRGATITITVLAVAFVILRFVARYVRGTPYGIDDYMLVLALIFTFAVLGINLAMVAHGLGVHKSELPPQHLETVSKLLISMECVYCTTVGIIKLSILAMYRRIFIDRVTRVATLILAAVTISWVISINFVSIFQCTPVAKTWNPTLPGHCINLKGSFIGNAVPNIMTDIANLSLPARQVWKLHASLTHRLAVIGIFLLGSFVVFASIYRFVTLFKFQPSDMTWTLSETNAWCVIEVGSGIISACLPTLRPLLQLVSDRFNTSQGTQSQSHGQTGESGFDSRQQRSGRRYWPGESTTHLAFKSGDELPLNSILATRAFSVHSAHPQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4E0</accession>
    <name>A0A2I2G4E0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras1 guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_437489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703052.1">
        <property type="nucleotide sequence ID" value="XM_024849379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4E0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4E0"/>
    <dbReference type="GeneID" id="36557078"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437489"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="45"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="213"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="482" mass="54691" checksum="BD1EF98C62C48D82" modified="2018-02-28" version="1">MEDSSRPASDPRHHFRYSSSSGSIDLPWFLHLDHEDEVVCDVVDGQVVVKSGTLAGLVEQLTRHDRLDAAFNETFLMTFNTFTSASVLFEMLVERFFIKPPDELDEVELQQWVEHKQHAIRLRVVNVLRNWLERFWIEPDNEDTRGFLRHAQTIVKDSPEMMATPTSSHLLTIIDQRLQGHQTMRRLIRTPTSSAPAPVVPKNMKKMKLLDVDPVECARQLTIIESGFHGRIKLSECLNKGWQKRGPDDSDPSTAVNAMILHSNKLANWVAETILNQSNMKKRVAVMKYFVSVADQCRAFNNFATLMSIISGLGLTPVYRLRFTWSQVSRRTLANLDELRHLMGSTRNFVQYRETLRSSAPPCVPFLGIYLTDLTFLDDGIPNHTSTGQINFTKRQKTAEVLHDLQQHQTTPYPFQPVPELQDYLVQGIQAAGDVHDMYERSLDLEPRQHGEEDLPGGQGAGYVATGSHMSSVVIASMVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G519</accession>
    <name>A0A2I2G519_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_201710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703272.1">
        <property type="nucleotide sequence ID" value="XM_024842764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G519"/>
    <dbReference type="GeneID" id="36550462"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_201710"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="139" mass="15928" checksum="7CDAAF41FBF505D6" modified="2018-02-28" version="1">MHAWHDVRSSYMYRNKYIHGIIGWMTGMIRTTPVIGSIAIPHNDRPETNTWRPRCLARGYAMSSARHKVRACVSRMMRYPISTCTCTCTCLCMLVGVSCRGQFGRSGGGWYFFSFLFSFLFLLLDLTGWGLTIYTICDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5L9</accession>
    <name>A0A2I2G5L9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glucose oxidase</fullName>
            <ecNumber evidence="12">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_456809</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703478.1">
        <property type="nucleotide sequence ID" value="XM_024851650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5L9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5L9"/>
    <dbReference type="GeneID" id="36559349"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456809"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014151800" description="glucose oxidase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB48176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="586" mass="64733" checksum="2625157E0E44BBAB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5Z0</accession>
    <name>A0A2I2G5Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_386653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703592.1">
        <property type="nucleotide sequence ID" value="XM_024845778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5Z0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5Z0"/>
    <dbReference type="GeneID" id="36553477"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386653"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000649">
        <property type="entry name" value="Compass component swd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000614">
        <property type="entry name" value="WD domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="477" mass="53473" checksum="D03F794070543EB8" modified="2018-02-28" version="1">MNLSLIDPFVLAQDYPDTLTEKLRSGHATCLRFNRKGDYLASGRVDGTVVIFDIETNGVARKLRGHTRQIQSLSWSRDGRYLLSSSQDWKCILWDLKDGSRVRTVRFEAPVYIAELHPYNHLLFVASLFEEQPVLVDVSSPKPIKRILPSAPFRPKSEEVDPAVAAKQAAQDAKQSTCVTIFTALGNHIIAGTSKGWINIIETQTCTTIHSTRLCNGVVILIRLSSNGRDLLINSSDRVIRTILMPDLSQLGIDLEPASIKLQVEHKFQDVVNRLSWNHVTFSSTSEFVTASTYMNPDIYVWERSHGSLVKILEGPREELGVVEWHPHRPMVVACGLESGNIYTWSIVTPQKWSALAPDFGEVEENVEYVEREDEFDVHPAEEIHKRRLDQEDEIPDVLTIDSQKSGADEDVESFRMPVLLDISDSESEEDIVAVGPGTMRRRSPGAGREWMNDGDKDSTAGGGRNGTGRGGRERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G616</accession>
    <name>A0A2I2G616_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_437987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703623.1">
        <property type="nucleotide sequence ID" value="XM_024849489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G616"/>
    <dbReference type="GeneID" id="36557188"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437987"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="171"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="291" mass="30681" checksum="142814009764C806" modified="2018-02-28" version="1">MPRPKTIAFFGATGGCTLNCLIPALQAGYRCNALVRSPPKLHALLHQHDVTVPTANLAVIQGSIDDADAVRRTLIVASASAPDTPNSSPDGDGELVDFIVSGVGGTPRFDNPLRPTLDNPTICQDAVRAVLDACRGLQSQGLAGAGSGTGSGSGSTGGNHTAAPSQRKKPFLIVVSTTGIASKRDIPIAMIPLYHWMLKVPHDDKRVMEEVIRGEMRREPEGERALSGYTILRPSLLTSGEGVGAGKIRFGVDDDAAVGYTISRKDVGAWMFERLVEGKGEFEGRVVSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G652</accession>
    <name>A0A2I2G652_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703659.1">
        <property type="nucleotide sequence ID" value="XM_024853401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G652"/>
    <dbReference type="GeneID" id="36561099"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476975"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="75" mass="9618" checksum="E5310EA6EB3D9CE4" modified="2018-02-28" version="1">MLLRVFLFFWRGGQKREKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKYSHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6B2</accession>
    <name>A0A2I2G6B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_361118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703719.1">
        <property type="nucleotide sequence ID" value="XM_024844453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6B2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6B2"/>
    <dbReference type="GeneID" id="36552153"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361118"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000426">
        <property type="entry name" value="Aldehyde reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF812">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="340" mass="36891" checksum="131B625E7BC438BB" modified="2018-02-28" version="1">MPSGLIFITGTTGFIGSAVALEALKTGYQLRISVRRESQILKLKTLFSKYGYSEKVDFVVVADITQESSFAGKLDGVDYVLHIASPLLHGTEKESYLDPAVKGTTAILTEAAKVKSIKKVVITSSIAAFIPVAGLPKGGVIKENNPWDFTIDPSADFTVPKNDSATAMRLYHASKLLAYNAAWDFKKDQSPHFSLVTLHPAFVFGHNHLQTTADEIKGGTNEMFFGTIMTGAPLGNITAVHIQDVAEAHVKALNESVPDGSTFLLAGERAAWKDVARIVGREYSKCGARIGESIPGESWDVDTTKAERELGMKWRSLDVIVRDVMDQQLGFRKGGVSSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6N5</accession>
    <name>A0A2I2G6N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_477147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703836.1">
        <property type="nucleotide sequence ID" value="XM_024853423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6N5"/>
    <dbReference type="GeneID" id="36561121"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477147"/>
    <dbReference type="OrthoDB" id="4384073at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014117086" evidence="1">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="194" mass="21958" checksum="A4D332607FCD24D3" modified="2018-02-28" version="1">MPSLTKYLLLPLLCVSPILAAYQPDYNAIFGEKCARPVQATQEIIAPIASDLVQKVCNQCDHDKITYEMLQRSESNNFNWAILHLKGVGFELRESYVPEKLFNLVWDFCIKKKWPTQSLCEDDFTEFRDCVLHTGMNEMVGPFAAYNQLVQDRCLRMPAAAARMVPLVKEEVDKFVGRVCPNGPQGRDQGVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6R9</accession>
    <name>A0A2I2G6R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_438147</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703872.1">
        <property type="nucleotide sequence ID" value="XM_024849522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6R9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6R9"/>
    <dbReference type="GeneID" id="36557221"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438147"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000069">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="52"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB48570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="146" mass="15347" checksum="1074938BDE088DA8" modified="2018-02-28" version="1">MASGAPVLSAEELHTLSAKAIAAKATAHCPYSQFRVGACILTRSGEYIPGANVENAAYPVGTCAERVAFGTAVVAGHKDFKAIAVATDIKPAASPCGMCRQFMSEFTGPSFPIYMYDGEGNYSLTTMNELLPRSFGPGDFPGKETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G761</accession>
    <name>A0A2I2G761_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenylacetaldoxime dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_383040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704029.1">
        <property type="nucleotide sequence ID" value="XM_024845628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G761"/>
    <dbReference type="STRING" id="1392250.A0A2I2G761"/>
    <dbReference type="GeneID" id="36553327"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383040"/>
    <dbReference type="OrthoDB" id="3359285at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025702">
        <property type="entry name" value="OXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13816">
        <property type="entry name" value="Dehydratase_hem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="370" mass="41760" checksum="3697EDD7796D4F5D" modified="2018-02-28" version="1">MTELEPSIPENLRTPRTVPATVPPNHTPPYPLFTSRYPEKVKDLVMAIMGAQYASADSNDGLAMQTISSFTGSDRVPESARPTLQEPAAVVDKSGPYTIAMIVYFPSRQTYDEWAETSGFRAWWTALDPRTQRHGWFLEVFFPSVDRFESILTHPDMHEGSSNIRSAVSKPLIEHGYWGSMRDRLPLSQTDELAGEKGHRSPDGVKRSDTRTARIRVPGRENLAVIRSGQDWRSAKAKERALYLNQLQPALTDGMNFLRDHGAETGCYSNRFMQVTDTAGNGVDRTFGLGYFDELASLEAWSKSHPTHLRIFGGFMKYAKEMGEEMAVRFYHEVLVLTPEQQFFEYVSCWPGTGMLTSLSGRESFNERNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G778</accession>
    <name>A0A2I2G778_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_436479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704038.1">
        <property type="nucleotide sequence ID" value="XM_024849165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G778"/>
    <dbReference type="STRING" id="1392250.A0A2I2G778"/>
    <dbReference type="GeneID" id="36556864"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436479"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="536" mass="60343" checksum="A2BB6CCCF17200EF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8Q8</accession>
    <name>A0A2I2G8Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_178207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704540.1">
        <property type="nucleotide sequence ID" value="XM_024842651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8Q8"/>
    <dbReference type="GeneID" id="36550349"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_178207"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="238" mass="26074" checksum="8A46325E2BA4691A" modified="2018-02-28" version="1">MDAEDGRPGSALPMDILAMVIFRCAVMPCRDSRVPEERVLLIPYSWTRSQVSREGSITPSRYRESTSGRTHGTGITGSLPLPALLPPRRSSFSLFLSISPSLGPSIPHPFNIYHPPKSNQSVPLPADRPSHRPQIRRILALLQTPSIPSILSPVPHFLLAKQGNLDLKSRCPTREAKPCSDRSIRLLIGPLSSISFFLSLRLGKNSETSALTRCKIARAAVFFAGSMPSGFPPYPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8W8</accession>
    <name>A0A2I2G8W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_509894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704627.1">
        <property type="nucleotide sequence ID" value="XM_024854719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8W8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8W8"/>
    <dbReference type="GeneID" id="36562425"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509894"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="556" mass="61005" checksum="E69C29509D04F8BA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G961</accession>
    <name>A0A2I2G961_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_509971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704724.1">
        <property type="nucleotide sequence ID" value="XM_024854730.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G961"/>
    <dbReference type="GeneID" id="36562436"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509971"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000745">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000645">
        <property type="entry name" value="HEAT repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000886">
        <property type="entry name" value="HEAT repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1868"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1587"/>
            <end position="1596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2054" mass="224343" checksum="480A16794B1E52E7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9U6</accession>
    <name>A0A2I2G9U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_426528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704953.1">
        <property type="nucleotide sequence ID" value="XM_024847711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9U6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9U6"/>
    <dbReference type="GeneID" id="36555410"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426528"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF6">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014185273" evidence="4">
        <location>
            <begin position="18"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="175"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="667"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="757" mass="79815" checksum="6B780BE3A59A3787" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAE6</accession>
    <name>A0A2I2GAE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_385117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705153.1">
        <property type="nucleotide sequence ID" value="XM_024845705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAE6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAE6"/>
    <dbReference type="GeneID" id="36553404"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385117"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="356" mass="39140" checksum="8CFC6E1E45299A1B" modified="2018-02-28" version="1">MSQNILITGGSGYLGGTVLARWTEAGLLEHGKLFSLVRTDSQAEATRQLYGAEPLRIDLEDEDAVKNTIVSNKITIVLYLIDAYYLKNQIAFIRALAETKKQIGQDAHFIYTTGTKQFSSLSGSPIDRDLVDNEPHLFDIHKAQNAPHEELQTATDTNIAVVEAGIEHGVKIYVFSPCIVYGKGEGFGNKISIQTVDVVIAATAAGRMYEFDQKGQIWPVSHVLDTVSLYFTLLDAILKNKNPGHGKNGFYLASSGKVAWHDIYAGIAKGLARRGKIPDERIELMNDTALEKIAKAQKVSPSSVIVKIGGRSTYTAANGKSLGWMPQYPPEHILESLDKEVEIILEELDSRHQGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAG6</accession>
    <name>A0A2I2GAG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short-chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_404486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705169.1">
        <property type="nucleotide sequence ID" value="XM_024846532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAG6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAG6"/>
    <dbReference type="GeneID" id="36554231"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404486"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF6">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="289" mass="31019" checksum="F6567D00DC826DBE" modified="2018-02-28" version="1">MSSTPKKQLTWLITGCSSGFGLSLVRFAQAGGHRVIATSRNPSRTPELVTEVESKGGKWIVLDVDSPASGDVITQLEAAGEEIDVLVNNAGFSIFSPVETATEAEMRAQMETMYFGPLRLIRAVLPHMRRRRSGTIVNMSSGASLDGRATMGPYAGAKAGLDGLTRVLAKEVSPFNIRTLTVVLGTFNTNMPNVCLVGEIPMHEDYHGTVSDQMMRFLTSGNFKPNGDKDKAMKALYEVVVGEGVGEGHQGEQLLLLGSDMTPRAKGVQEYLGQALEVFGPVTNGVDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAH8</accession>
    <name>A0A2I2GAH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_354694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705174.1">
        <property type="nucleotide sequence ID" value="XM_024844047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAH8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAH8"/>
    <dbReference type="GeneID" id="36551747"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354694"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014176762" evidence="7">
        <location>
            <begin position="18"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="533"/>
            <end position="534"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="579"/>
            <end position="580"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="601" mass="65281" checksum="BCC9483C7A291B5F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB10</accession>
    <name>A0A2I2GB10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_404805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705370.1">
        <property type="nucleotide sequence ID" value="XM_024846551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB10"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB10"/>
    <dbReference type="GeneID" id="36554250"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404805"/>
    <dbReference type="OrthoDB" id="5431239at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="637" mass="72436" checksum="B2B83B8FD299B6CF" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBE0</accession>
    <name>A0A2I2GBE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_473747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705477.1">
        <property type="nucleotide sequence ID" value="XM_024853076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBE0"/>
    <dbReference type="GeneID" id="36560774"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473747"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="13102" checksum="B4D5C24D77CBF10C" modified="2018-02-28" version="1">MAPVRRLKTKRLTRGYDQVRSDIESPRHLEQYKETKDLEDLPGLGKHYCVECSKWFESEHNMIAHRKGKNHKRRVKILREEPHTQKLADAAVGLRHDNGQRSQETVVDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBP6</accession>
    <name>A0A2I2GBP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_435466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705569.1">
        <property type="nucleotide sequence ID" value="XM_024848939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBP6"/>
    <dbReference type="GeneID" id="36556638"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435466"/>
    <dbReference type="OrthoDB" id="4381838at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="40220" checksum="0E82B9156F96502F" modified="2018-02-28" version="1">MESASSIPPEYLADDWENVYIRPRRLCRGYCCCYICGYRFCADLSRCGRSSIILRYHRYDRERVSRTENIELSRLPLSMENGWWAFQRMILFNQEDFAYRLSGVAMVHARNRTVPQGCVPLQRGTETDDTQPGVHRPTRRKCPLSTEWVGYIVHARCWELLSYHELGTVAEDDLDLFFAALRHRRLMMGSQCRAWRPEMYQEDPVRIKSVSSVVDLALEQARRTKPKKEPSRPCRPKAVQPISCRLPMEVIYIIFDYIPSQTVANTEKALNFYLSNSFWYSRVSANLFFETQGLTVEDVDWKRLCLKLERRLEKSEALRVRQYLLNCLDKILKVVEMLKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCD0</accession>
    <name>A0A2I2GCD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xanthine phosphoribosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_435737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705843.1">
        <property type="nucleotide sequence ID" value="XM_024849010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCD0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCD0"/>
    <dbReference type="GeneID" id="36556709"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435737"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="204" mass="23153" checksum="A995C1CA088681F3" modified="2018-02-28" version="1">MPQKFYVTYNQVHKLCQTSADQILNAFHPNLMIAIGGGGYVPARILRSFLKRSGEPNIPIQAIGLSLYEDLGRGDPEEVPGTKVTRTQWLDLSSLEMANLIGKNILIVDEVDDTRTTLEYAVRELEKDVELAQKQLGREGEKTNFFVFVLHNKNKSKKGVLPADMMESHRYHAAVTTEDVWICYPWEAKDIDEHDQLAEKNPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCV4</accession>
    <name>A0A2I2GCV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_474227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705969.1">
        <property type="nucleotide sequence ID" value="XM_024853112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCV4"/>
    <dbReference type="GeneID" id="36560810"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474227"/>
    <dbReference type="OrthoDB" id="10347188at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="222" mass="25240" checksum="D1FAAC820CA4A579" modified="2018-02-28" version="1">MDRKVVRNEYPRPLRLQDVPPRLIELQQKLNELHEELNSVQEGHTPIQESLITEIKSASHNIDRELDELRKEVETRRRETKIRLFAFLSWADQNHNPSAADKNLSDLSVLGLGADVVADAQMLKVTGLKECELFNEIYSCSVSVAQRLQTDQMTDVLKVVDVAADCRLMQRFQAESVMLPGEQAAFARLKACLDEIDPEHSIPVAEVMKMKGICEEFRAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD60</accession>
    <name>A0A2I2GD60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_474358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706104.1">
        <property type="nucleotide sequence ID" value="XM_024853129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD60"/>
    <dbReference type="GeneID" id="36560827"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474358"/>
    <dbReference type="OrthoDB" id="4509176at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="150" mass="16280" checksum="9E034DFFA3BB5AD4" modified="2018-02-28" version="1">MAPEFDITSSQSERYCIYYLLASILAAVDEGRTARPSKSSFISSLISIHQLRRNAPANMKSFSVLSLLVLTSSALALPTPDQSGVAVVDEAVKTGDYKRSDDLKARCGLALSPDQAGTEDAAKIAARCAIPWTQNYGEYDDVEKRDDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD74</accession>
    <name>A0A2I2GD74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_463911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706127.1">
        <property type="nucleotide sequence ID" value="XM_024852200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD74"/>
    <dbReference type="GeneID" id="36559898"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463911"/>
    <dbReference type="OrthoDB" id="4507975at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="313" mass="34622" checksum="6746B524E32B71FB" modified="2018-02-28" version="1">METSSSPRSKRKASVSEALLQKRSRPSRCYVPECESAAHSRPAAGRLPEEGSIRSIICNNPRKRLYVAPIAWTSEHLQLLANDRGKRASARPDSSYPNMQPFSRIGSHRCGSLPFDYERRAAAKLPTDGVFSSYVTPSSLAYITFDTIKSLREKYTRVFKAKSVATVHIRRHSLRVLEPPNPVEDPYIVALLIALVQDQRRQQQRGRQHAKTTTDPVSSDGSKCITDSQACNKVNILAITGFVTTSVYVYTAIIPVEFLDKFDNPTHSSPSSPITVTCGGLPVKGAKSFETLHRLLCSGFCKTDAPQRSNPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDA4</accession>
    <name>A0A2I2GDA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_463916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706133.1">
        <property type="nucleotide sequence ID" value="XM_024852202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDA4"/>
    <dbReference type="GeneID" id="36559900"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463916"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="231" mass="23738" checksum="2D73D4FA0BF66CF5" modified="2018-02-28" version="1">MSFSDLIQNTINKHTGGGDNNSSSSPSYGNEGPYSAGGSSHYNTPNAANPNPHYGGSGGYGSDDDFNPAVSHAQAEHGEDSSLFNTALSFIKDRKSQYAQKDNYDIDESHMVQSHQALYGGGGDERAHDSNSLGAGAAMQALKMFTSGGGSSSESSGGGMDKNKLIGIAMAQAGKLWEEKNSNGGASEDKQSAVNKAAEMALKMYMKGQGSGSSGTGGPGGLMSLASKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDK9</accession>
    <name>A0A2I2GDK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase ATG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_353951</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706286.1">
        <property type="nucleotide sequence ID" value="XM_024844003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDK9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDK9"/>
    <dbReference type="GeneID" id="36551703"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_353951"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000861">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000065">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="241"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="737"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="796"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113202" checksum="B0B757F4BD4E8EDF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE52</accession>
    <name>A0A2I2GE52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_474687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706442.1">
        <property type="nucleotide sequence ID" value="XM_024853172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE52"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE52"/>
    <dbReference type="GeneID" id="36560870"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474687"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="803" mass="89507" checksum="875156F543303771" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEG6</accession>
    <name>A0A2I2GEG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_382672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706575.1">
        <property type="nucleotide sequence ID" value="XM_024845611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEG6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEG6"/>
    <dbReference type="GeneID" id="36553310"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_382672"/>
    <dbReference type="OrthoDB" id="2128064at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="3">
        <location>
            <begin position="79"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="218" mass="23325" checksum="4A34687A15AB8509" modified="2018-02-28" version="1">MLSTRLCPLSPRISRGSGQHILLSLRPFSTISPRQACPKSSCAGKNTPSPASHNPGQDSNSNADTRSLLRASFWSSRPTWKRASINTLRCLVGCTIGDFSALWVLQTYLPGLGMGTIMGLSMASGISTSILLETMLLKHGPDKLPLPAAFRTATGMSLVSMLAMEAAENAVDWHLTGGVVAVQDPAFWAAAAVSIAAGFLAPLPYNYVRLRRWGRSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEZ1</accession>
    <name>A0A2I2GEZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_487283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706748.1">
        <property type="nucleotide sequence ID" value="XM_024853950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEZ1"/>
    <dbReference type="GeneID" id="36561651"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_487283"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="618" mass="69545" checksum="974CB8CDE575B97F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF30</accession>
    <name>A0A2I2GF30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_443696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706796.1">
        <property type="nucleotide sequence ID" value="XM_024850573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF30"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF30"/>
    <dbReference type="GeneID" id="36558272"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443696"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="141"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="39513" checksum="81B42CF2BB51BCF5" modified="2018-02-28" version="1">MVNWGIISTGNNATKFAKDLLIDPSTRGVHDITHTLTAVASSTSLEKARSFLSAMNAPSTTTAYGSYNSLFADPSVGIVYITTPHSEHFQNARAALLAGKHVLLEKSFTVNAAQAKTLVALAREKGLFLMEAMWTRFFPLMQHVRQLVRDGAIGSVQRVVADRNLGRDVERLYGTEHRLVNPALAGGALLDLAVYPLTWIFQFLYHDSLSSDGTKSRPLVSSSVIKYAATGVDETATVVVTFPDSKAQGVATASLRVTSDPTDPGVRIFGHKGQIQIFGPAARPLSIAVVDYAAADTRAVERKDFDIPVGHGLFWEADACARALAGGERESDVIPLDETVLIMEVLDQVREQNRLRYPDDIESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFG4</accession>
    <name>A0A2I2GFG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_350792</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706925.1">
        <property type="nucleotide sequence ID" value="XM_024843823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFG4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFG4"/>
    <dbReference type="GeneID" id="36551523"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350792"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB51623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="470" mass="54479" checksum="13E4D29BE735A647" modified="2018-02-28" version="1">MGLITNIFYYSFHPGELRSILQWKVWHNPVHERDEKNETETQKACFKFLDLTSRSFSAVIKELHPELLLPVCVFYLTLRGLDTIEDDTSIPLETKEPLLRGFKDLLEQDGWTFTGNRPEEKDRELLVQFHNVITEYKNMKPAYQAIVKDITDKMGNGMADYCRKAETDDASVKTTVEYDLYCYYVAGLVGEGLTRLFVEAEFGNAALLKRPRLHKSMGLFLQKTNIIRDVREDNDDGRRFWPKEVWSKYVTDFDDLFKPENRELALNCSSDMVLNALEHVEDCLFYLAGLREQSVFNFAAIPQAMAIATLELCFRNPAIFERNVKITKGDACALMTESTQNLRILCGIFRRYARRIHKKNTPKDPNFLKISLVCGRIEKFIETIFPSQSAEDAQRKVTGEKTEEEQKKAQQDAETREDVFFMMMLMGVIVLVVSLLMIGTAWYLGARFDLAWQELRSGNFKPPREVRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFG9</accession>
    <name>A0A2I2GFG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_422579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706879.1">
        <property type="nucleotide sequence ID" value="XM_024847445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFG9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFG9"/>
    <dbReference type="GeneID" id="36555144"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422579"/>
    <dbReference type="OrthoDB" id="4491087at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="231" mass="25508" checksum="768783C0005BA2B7" modified="2018-02-28" version="1">MEAARKTPRQYIRFPHFVSADRHQDPVLNGPAHFQKKRQGVYLPRLDVVIRDNPQPRSENAPSVHNICWKALADQPSIDLLRHLGLAMTPLVWTGLPQSIHQLALPGTIEPLSLEVDRRDGGNTALSELLERCGRLPAELIAMIWDLIPPCTVRCLLALSSAKSIWSTLPLVATGRKFAAFAKGTRSMGMKAPLLSAYRFPSLSWPSSLYLELSGFEGSVFSLKAKPIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFM1</accession>
    <name>A0A2I2GFM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pectinesterase</fullName>
            <ecNumber evidence="5 13">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_352612</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5 13"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706953.1">
        <property type="nucleotide sequence ID" value="XM_024843929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFM1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFM1"/>
    <dbReference type="GeneID" id="36551629"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352612"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013984283" description="Pectinesterase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="14">
        <location>
            <begin position="28"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="331" mass="35991" checksum="4BD3B7648DD33D44" modified="2018-02-28" version="1">MFKSVLTSAFFAATALAASRMTAPAGAIVVAKSGGDYTTISDAVGNLSTTATTTQSIFIEKGTYDEQVYIPSMKGELLIYGQTEDTTTYEKNLVKVTHNIKLADVENDDHTATVRNHAENSSVYNLNFENSCGQVCHQALAVSAYGENQGYYGCKFIGYQDTLLAQSGNQIYAKSLIQGAVDFIFGQSARAWFHQCDIRVVEGPSAAHITANGRRSESDESYYVIHKSTVEAADGDSVKAGTYYLGRPWSEYARVVFQKTSMSDVINSAGWAEWSDASPNTDNVTYAEYGNTGKGAKGDRVSFSHKLDEAISISEILGADWQSWVDTSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFR6</accession>
    <name>A0A2I2GFR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_84142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707025.1">
        <property type="nucleotide sequence ID" value="XM_024855414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFR6"/>
    <dbReference type="GeneID" id="36563121"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_84142"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="244" mass="27395" checksum="9401E25EAEF868B2" modified="2018-02-28" version="1">MTAMEKQQKKKREKSPRARRMGGYTNGEREQGECHLQARAVKEKSGYCANQKDAGSTVPRRCVRRRKGLVNGVCDGSIRGWRWRARQTERGRERETKGGGKGRVEDRQGERGRPEDYLRQGETDDAAIDLQCKSWESRSDGIKSSGEKRSTEETKPKPKPTEEPNVVIPARSRASGAKGRIHSHSGVYKMYISVRLQILKILETGQLLPVCEGAWGGFDPGNNNELGWAINHGSPGLSMWFEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG64</accession>
    <name>A0A2I2GG64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glc8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707177.1">
        <property type="nucleotide sequence ID" value="XM_024848570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG64"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG64"/>
    <dbReference type="GeneID" id="36556269"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433770"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31160" checksum="6960331D805CE7A2" modified="2018-02-28" version="1">MAQDMDEMHKRPKGILKNSSSHSVLRASHASETLAPPTPAIETADNKELTLQNTLQNAGRRRSSSNTRPGTSSRRQSLADVKDDENSPRLKWDEANLYLTEQEKTAKMKIDEPKTPYAPRYDPAEDEDEMQLAEAEEKLIDAQDVVVDELDESTKAPKKAVAEDEIPELELGDPEESLASGAHARGDGRIVRGRSLSNESHRSDKHVVVGAGEANGEAGLGEDGMVTAEEAQEKHRQFERQRKRHYEMRNIKELLAYVDGLSAVIPSPNPSPFPPFQCDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG72</accession>
    <name>A0A2I2GG72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707186.1">
        <property type="nucleotide sequence ID" value="XM_024848574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG72"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG72"/>
    <dbReference type="GeneID" id="36556273"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433784"/>
    <dbReference type="OrthoDB" id="5339332at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="416" mass="44777" checksum="75304D6FAB9CADBA" modified="2018-02-28" version="1">MDVRSDLLSGYSFRSSASASASVDRHRHQPNFGRYESTLDDSARAYRATALQQLNGAPRPLSWKNRQTNHSASRSSTLATQPVLVRAYSGGPAEDRSPPSKMSLRRSFPFTGSSRAQQRGPEIPSDEEFSIDSILRAIEPNIRGTLDSIGEICGRSKLSLANEYGSHIAPLGEIRAPPGGLVTVEEASSDNERQANDNVVIYDDENSVTDGRDHISFSHYGYFQHGRQPGMTSSHGAFHSMHPISEADVSSTQAQPLTPRSAGFNPGPDPDVDLGLPAASRESASKPRSYGRALLAKKAVSGTDQTQGILTPALVSEILLDAQADSHAVGSAPSSEPRRRSPKGHPRSRVDAVGDRESSSGESPKASVLGDVQALIGWLTQFAGYRADAGESKQTAEMRLRMTLERQNDLVSLDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHD2</accession>
    <name>A0A2I2GHD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_434086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707590.1">
        <property type="nucleotide sequence ID" value="XM_024848641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHD2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHD2"/>
    <dbReference type="GeneID" id="36556340"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434086"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="12029" checksum="0BDD68D0F6B9F67B" modified="2018-02-28" version="1">MNLWLVGGNGDVNAVILLIWALEEQGSSNRVGGSAEVYVRDRQGMPVLQQRVQIFPVSKHQSLQISRRLLFGRTVFPGRNPDELLDLDLPGLREVAKICMEFMGLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHP7</accession>
    <name>A0A2I2GHP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_423277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707702.1">
        <property type="nucleotide sequence ID" value="XM_024847494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHP7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHP7"/>
    <dbReference type="GeneID" id="36555193"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423277"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000198">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB52400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="672" mass="73418" checksum="427C00A02061D168" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIC2</accession>
    <name>A0A2I2GIC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_507382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707930.1">
        <property type="nucleotide sequence ID" value="XM_024854480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIC2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIC2"/>
    <dbReference type="GeneID" id="36562186"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507382"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="372"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="463" mass="51986" checksum="EB691FAF32B9A5C1" modified="2018-02-28" version="1">MSAPKVAENMLWGGRFTQGLDPLMVQYNESLPYDRILWKQDIAGSIAFARANTKSGILTPHEFSEIERGFKQIAEEWSTDSFVVKANDEDIHTANERRLSEIIGKEIGGKLHTGRSRNEQVATDMRLWLRDELRKLDNFLCDLIKVCIARAENDIEYIMPGYTHLQKAQPVRWSHWLLSHATAFASELQRLREVTRRVNRSPLGTGALAGNPFQIDREQMAKELGFEGLLYNSMNAVADRDFAMETMQWGSSFMLKISRWAEDLIIYSSLEFGYVRLSDAYSTGSSLMPQKKNADSLELLRGKSGRAFGHMAGLMMTIKGLPTTYNKDLQESIEPLLDHIKTVSDSIQIATGVLSTITVIPEKMTAALAPEMLATEIADYLVRKGVPFREGHHISGRVVALAENQNVPMDTLSLEQLQTVDARFDEAVRACLDYERAVELKDAVGGTSRRAVLEQTSVLRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIC7</accession>
    <name>A0A2I2GIC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_453937</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707926.1">
        <property type="nucleotide sequence ID" value="XM_024851400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIC7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIC7"/>
    <dbReference type="GeneID" id="36559099"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453937"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="536" mass="57535" checksum="581EC5254EF707BF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIP3</accession>
    <name>A0A2I2GIP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative translation repressor/antiviral protein Ski3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_444659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708042.1">
        <property type="nucleotide sequence ID" value="XM_024850645.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GIP3"/>
    <dbReference type="GeneID" id="36558344"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444659"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="648"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="724"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1423" mass="159161" checksum="A9905FE0A885FFC4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ41</accession>
    <name>A0A2I2GJ41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_350209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708202.1">
        <property type="nucleotide sequence ID" value="XM_024843786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ41"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ41"/>
    <dbReference type="GeneID" id="36551486"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350209"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="355" mass="38715" checksum="77061748FA5B5B97" modified="2018-02-28" version="1">MALPQPSNSERTIRKIDIAQVSLSLQDRLGLAKVKYQNGRLHALDQNGNRHITLGSDKPSDSSSEISQSRCETPMTSPPLRTSTYSKELPRSSRNRHAATFNSKVMQPMLSASRKRLRSDSITDRTVKAPRVSWKSSYRLPESSPGMNRHLASRPHPLPFISETATIPEFSSPAYHHLSDDDNDPDLPVHSFQNVSSMVGSSPPRTPPPKHARLSRNDRNLRHEDGADLLLYLANSPTPASVAGKPQPRDFPPSTPPSQHAVLPGLTPTPGGGVFPNFGTPNQQFNFADFVNVTPSPAQPAFGGRTPGGPSRTPLTAKDRRRSNLDNLLPPGADSPKNRVKEASTVLQLGGELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJI4</accession>
    <name>A0A2I2GJI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative tocopherol O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_472916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708340.1">
        <property type="nucleotide sequence ID" value="XM_024852995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJI4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJI4"/>
    <dbReference type="GeneID" id="36560693"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472916"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="4">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="378" mass="42667" checksum="0BBFA2732DF50B7E" modified="2018-02-28" version="1">MVSSTVVLKEDPDVALMKAMHGKSAEEKNAFFAMLKKNNSAHREITNEYVRRWKDEKGVDATTEEARKERTTEYMGVVNNYYDLVTDFYEEAWAQSFHFCRFSLGEPFLQALARHEHYLAYKLGIKGGAEVLDVGCGVGGPAREIARFTGCQVVGVNNNAYQIARATKYAEKAGLSDQVSFFKGDFMHLDFPPNTFDFVYAIEATVHAPSLQKVYEQIFRVLKPGGRFGVYEWVMTDRFDETNPEHRAIRLGIERGNGIVNMKTQAESIEAIQAAGFVIEHEEDLAERPDPIPWYYPIAGELRHTRSLWDMLTVLRMTKFGRAAMGQLLWTLETLRLAPAGTSETAQELADGADHLVRGGQLGLFTPMYLMIGKKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKI9</accession>
    <name>A0A2I2GKI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_376211</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708697.1">
        <property type="nucleotide sequence ID" value="XM_024845357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKI9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKI9"/>
    <dbReference type="GeneID" id="36553057"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376211"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="483"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="866"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB53395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="891" mass="100209" checksum="1CE72527478D501C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKM5</accession>
    <name>A0A2I2GKM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein hob1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_400649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708727.1">
        <property type="nucleotide sequence ID" value="XM_024846337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKM5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKM5"/>
    <dbReference type="GeneID" id="36554036"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400649"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="351"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="410" mass="46933" checksum="92D97CF92D1DE15E" modified="2018-02-28" version="1">MSLKGFQKTLVRAPQTFKSRFNIGENTKDVVYSDAERRFQELEKETKKLHDESKKYFDAINGMLSHQIEFSKAMTELYKPISGRASDPSSYTIEGNPEGIQACEEYEAIVRDLQESLAPELEMIESRIISPADQLLEVIKVIRKVAVKRDHKKLDYDRHRNSLKKLQDKKDKSLKDEKALYKAENDVEQATQEFNYYNDLMKDELPKLFALEAEFIRPLFQSFYYMQLNVFYTLHERMQGINIGYFDLTLDVEEAFEKKRGDVKERAEELTIVHFKTKGLGRQNSKFGPKDKMANEGKERFAPRQKDPEAGVDNPPPPYTSAASSGSSFIAAAKSKPAPPPPKPKPARFAAQVETVTALYDYEAQAHGDLSFSAGDVIEIVQRTDNQNEWWSGRVDGREGQFPANYVQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL54</accession>
    <name>A0A2I2GL54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase with different specificitie</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_431427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708903.1">
        <property type="nucleotide sequence ID" value="XM_024848035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL54"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL54"/>
    <dbReference type="GeneID" id="36555734"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431427"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="254" mass="26085" checksum="AD24351BF0C79D34" modified="2018-02-28" version="1">MVSYSGKKAIIIGGSHGIGLSTAQLLVDRGAQVLVTGRSPDPICTAQEQLGHQAHVVACDISSVTAIADLIPVADTFFGPGARVDLIFINAGYAALEPFHTVTEDSFRRTFDTNVFGAFFAAQKLAPLVKDGGALVFTTSVANQVGIPGMATYAAAKAAVQSLVQTLAAELTGHGVRVNAVSPGFVRTPTMGVASASADDRAAFEGEGVQATPLGRIGDPEEIARAVLFLGFDATFTTGSQVVLDGGLASLQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLK0</accession>
    <name>A0A2I2GLK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_344355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709054.1">
        <property type="nucleotide sequence ID" value="XM_024843453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLK0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLK0"/>
    <dbReference type="GeneID" id="36551153"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344355"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="93"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="374" mass="41755" checksum="469D1839B64F29B3" modified="2018-02-28" version="1">MLGDFSRPLCLSSQRSNNQVAYGTKTISTNKSQPKGIQLGSSRGPHSYRPTRYTQPLRPSLFQNQIEHRAPYTTQASTSGEPTIHDIFESRTGTWQYVVVDPSTLAAVIIDPVLDYDAATNSVTTTAADSLLALVQEKGYNVERILETHVHADHLTAASYLQSRLAQQQGHSPPIGIGKRIEQVQKLFSQRYGVPEQEYKGIFNKLFDDNEVFNIGKLEAMAIHLPGHTPDHLGYKIGDNVFCGDSLFHADIGTARCDFPGGSANSLFQSGHKLLGLPDRVKIWTGHDYPPEERKSPMSWMSVEDHKAENKHLKAGITEDEFVALRKERDTKLAEPKLLHQSLQINIRAGHLPEPTETGHRMLHLPLKLKGVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLK8</accession>
    <name>A0A2I2GLK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_431582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709072.1">
        <property type="nucleotide sequence ID" value="XM_024848069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLK8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLK8"/>
    <dbReference type="GeneID" id="36555768"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431582"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="156" mass="18324" checksum="DCD5DC46F4464770" modified="2018-02-28" version="1">MAIHYLILLSRQGKVRLAKWFTTLSPKEKAKIIKDVTQLVLSRRTRMCNFLEYKDTKVVYRRYASLFFIAGCASTDNELITLEVVHRYVEQMDKYYGNVCELDIIFNFQKAYFILDELLLAGEMQESSKKNVLRCISQQDSLEDMEVEEDVVTKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLW0</accession>
    <name>A0A2I2GLW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_396811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709168.1">
        <property type="nucleotide sequence ID" value="XM_024846137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLW0"/>
    <dbReference type="GeneID" id="36553836"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396811"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013984746" description="Cutinase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="212"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="214"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB53866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="296" mass="29285" checksum="1C9EA3442004F026" modified="2018-02-28" version="1">MKFSLSLVALAGLAASTPAGLQERQLSGGGNELRDGSCKPITFIFARASTEPGLMGISTGPAVCSDLKKAKAGQVACQGVGPKYTADLMSNALPDNTSPAAIEEAVGLFKQAASKCPDTQIVAGGYSQGTAVMDDSIKKLPDDIKDKIKGVVLFGYTRNAQEHGQIGDFPKDKVKIYCATGDMVCDGTLIVGPAHFTYIANTGEASKWLEGKLDSSSSSSSSSSGSGSSTSSGSGSSSSQAASSSSSGSSDSSSSGSSGLGGLGSLFGGGSGSSDSSSDDSSSGSSGGLGSLFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM75</accession>
    <name>A0A2I2GM75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_6780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709278.1">
        <property type="nucleotide sequence ID" value="XM_024855333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM75"/>
    <dbReference type="GeneID" id="36563039"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_6780"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="101" mass="11146" checksum="F4F9D6995A4D6FBB" modified="2018-02-28" version="1">MSRRGSASRGCPGTYEVRSGSYYEVRYTSDGNCASGHQSQHQSQHQSQHQSSNYYDSSNHYQQSPMNMGQSDYPGASMALENCCEYGSSSRSHATSGRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMQ9</accession>
    <name>A0A2I2GMQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_451979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709457.1">
        <property type="nucleotide sequence ID" value="XM_024851240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMQ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMQ9"/>
    <dbReference type="GeneID" id="36558939"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451979"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="449" mass="51043" checksum="50A28358E4CF541E" modified="2018-02-28" version="1">MAFKITEHVIDSQYIREYPRSTATEDAPLKLAIKKYTPTDNLNPLPGDVTIIAAHGTGFPKELYEPLWEDLVARSKHDGYRIRAIWMADAVNQGASGILNEEHLGNDPSWADHGRDLLHMINHFRADMPQPIMGLGHSVGGAQIVHLSLIHPRLFTTIGLLEGYLTHEDVGERGRALLWATLHKPDVWPSREAAIKQIPKFFKIWDKRVLDRWNQYAYRDLPTLVHPDTPENFDPQNPPVTLTTTKHQELTMYTRPNPKRHKQLGLPEELDNNKGYGPSPPHDPLFYPDMLGPLYESQLIYCSEPLLAFRLLPHVRPSVLLVYGDSSELSLWKLGQKAAQRVGTGFGGSGGLAYNRVKHVLLPKCGHMLPMEKVTETAGVVGPWIGQQLQWWREDQRRLAEGWEGLSIKDKSTIGPEWKATFVKAIKTHPKFQEHAKKKKEKKQRSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMR6</accession>
    <name>A0A2I2GMR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_482567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709452.1">
        <property type="nucleotide sequence ID" value="XM_024853888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMR6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMR6"/>
    <dbReference type="GeneID" id="36561586"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_482567"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF33">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="262" mass="28854" checksum="B6D9677EC1EF6652" modified="2018-02-28" version="1">MGSWSLYDYEPSKPAALVAILAYALSSIYHIYQLVQLKAYFFTSFIVGAIMMTIGYISRTISSNGTTALAPYIAQNICILLPPSLYAATIYMIYGRVVIHLRVPRLSLISPYKVTKIFVVGDTIAFLTQASGGGMMAMQELASMGHKITIVGLFVFFGLFLTVTGTFVRRLGNRGTAGSQVPGDVKRLLTVLLVVSGVIIVRCLYRIVEFCQGNDGYLMRHEVLMYVFDTIPMFGVQVVFHFFHPGVILGQGRGFEAVDVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMW7</accession>
    <name>A0A2I2GMW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_460437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709540.1">
        <property type="nucleotide sequence ID" value="XM_024851940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMW7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMW7"/>
    <dbReference type="GeneID" id="36559638"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460437"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="444"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="525" mass="58208" checksum="F2C0A7C7DEF93490" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN05</accession>
    <name>A0A2I2GN05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome oxidase c assembly-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_397504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709570.1">
        <property type="nucleotide sequence ID" value="XM_024846181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN05"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN05"/>
    <dbReference type="GeneID" id="36553880"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397504"/>
    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27894" checksum="8533F5E5B5F1B9F5" modified="2018-02-28" version="1">MSRSAADATRFTATGPYASSKPGNAPYKLPSHMSNSASNSQSQGPGGNPETPKEKVERLRAQARAARMAQSTSRVDQVVDVGRRFANKAHKVMVYSLITASGVCGALTVYSLVSLTLYNRRQRALWVEKELQKLQDAKTAHANGSATSEQLELLKNEQIGEIFKQKKEEQKAERPWDKVKQYLLGGLKPEDSPSGHPQSGSVPDNKPGVLEALNAKALEDAQSKEPSASGQLDAMAENAENAAKQSARGWKSWFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNX2</accession>
    <name>A0A2I2GNX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_373836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709880.1">
        <property type="nucleotide sequence ID" value="XM_024845261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNX2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNX2"/>
    <dbReference type="GeneID" id="36552961"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_373836"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="481"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1004"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113733" checksum="8B9C34A76082398B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPG6</accession>
    <name>A0A2I2GPG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_421424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710072.1">
        <property type="nucleotide sequence ID" value="XM_024847359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPG6"/>
    <dbReference type="GeneID" id="36555058"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421424"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="351" mass="39493" checksum="9B714508A522D5D0" modified="2018-02-28" version="1">MAESLQLGPLFEALQVYDPHDEEVTLDGIIWHLQCIEMLDRAEELLGAQRLLIFAVLGWRSMLFLAAFNVCSLGHLSIRQDSCQPQSGHVFDEYIQPAGYVSSLPLAILLKAYGNLIPSGSSSSTQVASEKSKASSSWLPLYPKETNAYLLQTLLRVRIRWVDTLALHLDYDKSSKTLSIFAYPSFCLSTLHAGGLLYSFASIDHGDANPDDISQLLREVLLSYRLLFGQSGPSRKLFRRHLTPSDIPPCEMDPLLPLLCTNAQLPYFSPDMPPDRPIYFAARDFPVYSERIELIRKELRDARPKSLADQVRDKRDTLQYWTFWLVAIFGGLGLVLSLVQVIQQGIQLSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPP1</accession>
    <name>A0A2I2GPP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_398631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710138.1">
        <property type="nucleotide sequence ID" value="XM_024846234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPP1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPP1"/>
    <dbReference type="GeneID" id="36553933"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398631"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="238"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB54836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="393" mass="44550" checksum="9FE23CEF50F4FD24" modified="2018-02-28" version="1">MWRDRTNLYISYRQSFTHHPAKKPRYIGSTNGFSDTPSHAEESRRLIGDSGGFDDDGDAVIEMDVLPPRWVDVQDEVTELLADIAQKSAHLDKLHQKHLLPGFGDEEARKQEEAVIERFTQDITRAFHDCQKAVQKIETMVRDAKQQGGVTNGDETMAKNIQISLASRVQDASARFRKKQSTYLKKLRGLEGVPSPFDRAPTPQNPYTDPSLMESDADKSFSQSTLMQTSQRLTGENDAAIMQREREINDIAKGIIELSDIFRELQSMVIDQGTMLDRIDYNVEKMGTEVKAADKELKVAGNYQRRTIKRKILLLLIILVAGMFILLLVKPKKNDSPPPPESAPAPPSSPPPQSNEQSADVVPRNFELVYRRKRRPSSSHPVRRKWGDPDIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ04</accession>
    <name>A0A2I2GQ04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_483741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710256.1">
        <property type="nucleotide sequence ID" value="XM_024853909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ04"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ04"/>
    <dbReference type="GeneID" id="36561607"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_483741"/>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="344" mass="39768" checksum="7575604587C361E7" modified="2018-02-28" version="1">MSISRVGYNPHPDMVTRNYGQLSSDIKNWTDRYVCEEMPSLSEEQKQKIIESLETYCIQESWDTIQSLLSPLSREHFHLGLCEAMINKWLFTHFLDRTFWFLDGKRDETDEIGDPLFSERLQYLYQRYYHASPVNAVWWKMVTLGLANLKKDSTPKCPRDNEFGDENRKRQADMAESLANQLLSDSLFQLFLSDLPDEEEETMRRDFLITIFKSGAEHLTAHEVTLGGQVKVHQLPELEKFDPSTGLMFSGLVHGRERKDTPPVIPKPHGRVILVLRPGVYRYDLPNKFVPYDRHVSLVELPTDADSYLLCKAEVVVEAAQASPSDANQADPNDQDVWFARDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQG7</accession>
    <name>A0A2I2GQG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_374645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710421.1">
        <property type="nucleotide sequence ID" value="XM_024845293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQG7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQG7"/>
    <dbReference type="GeneID" id="36552993"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374645"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.190.10:FF:000004">
        <property type="entry name" value="Putative Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="284"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="370" mass="41532" checksum="A243675CAFE11C8E" modified="2018-02-28" version="1" fragment="single">MPELAEVSRIVYFIRQHLVGKTLSKVSTQNDDIVYGKAGTTAAEFQKAMEGKKVVGAGQQGKYFWIAMSSPPHPVMHFGMAGWLKIRNADTYYYRTDKPEDKDWPPKYWKFLLETDGDPKTEAAFVDFRRLSRVRLVDCPAEEIRSYSPLKENGPDPVADKEAVSENWLGEKLKSKKVPIKALLLDQANISGIGNWMGDEILYHARIHPEQYSNSLNNDQIKKLHSSIHYVCSTSVDLLADSDKFPEDWLFKHRWGKGKKNTPSVLPNGERITFLTVGGRTSAVVPSVQKKTGPVTKGASGEDTSGTQSNSKRKRSAAPKEESDSEAKREEPTPKKTGSKPQAKKPVKTEDNEEEKAADLGRRRSTRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQK4</accession>
    <name>A0A2I2GQK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_432673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710436.1">
        <property type="nucleotide sequence ID" value="XM_024848316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQK4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQK4"/>
    <dbReference type="GeneID" id="36556015"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432673"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="139" mass="15630" checksum="2E93C1FA2BF58FD5" modified="2018-02-28" version="1">MGAKIPRNFRLLEELEKGEKGLGAEACSYGLADGEDMMMSNWNGTILGPPHSVHENRIYSVNIHCGPDYPDNPPSLQFISRVNLPCVDARTGKVDPTKLPCLAQWKRENTMETILLELRRYMALPQHKKLPQPPEGSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQR5</accession>
    <name>A0A2I2GQR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_470638</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710522.1">
        <property type="nucleotide sequence ID" value="XM_024852778.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GQR5"/>
    <dbReference type="GeneID" id="36560476"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470638"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000006">
        <property type="entry name" value="37S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="923"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="953"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1006"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1051"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1092"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1135"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1178"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1203"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1272"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1318"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1364"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="15">
        <location>
            <begin position="523"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="620"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB55220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1388" mass="153302" checksum="2602F240C6F64504" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRN3</accession>
    <name>A0A2I2GRN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N-alkane-inducible cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_422076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710840.1">
        <property type="nucleotide sequence ID" value="XM_024847413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRN3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRN3"/>
    <dbReference type="GeneID" id="36555112"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422076"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014157379" evidence="9">
        <location>
            <begin position="20"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="482" mass="54951" checksum="1E2EE1020F7E0399" modified="2018-02-28" version="1">MWLYFVLVAILVIATRHIAHRIKRWKTTRHYALKYGTKDPVILAQIALPEGGNYDKEIMRAFKEHRGLELIQKRHIAGGYTFQTHTIGGRIINTSEPENIKTIQASRFEDYSLGFRQVALGPLLGKGVFTNDGKDWEHSRALVRPNMSKALYTDFNNLERHVQEMISHMPKDGIDVSSEFLFGESVRAFEAAEGSDEAKFGAAFDYASGETVRRLHYEPYLFLYFNRDFTKACKTVHRFVDKVIAKAATRRVEGKANQYIFLDSLMKSVTDPQRLRSETLNVMQAGRDTTASLLATVFYLLARHPEVWTKLDAEIGELNGKPPTYEELKKLTYLRYVMNETLQVHPVAPINSRVAVRDTILPVGGGPDHKSPIFIPKGQKVSFPTYVLHRRSDIYGPDAHEFRPDRWGEPTFRPGWAYIPFNGGPRICLGQQYALTEAVYTIVRLVQTFKAVEQRDFTRYKESVRVSASIFGGVQIGMIPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRU1</accession>
    <name>A0A2I2GRU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_452917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710899.1">
        <property type="nucleotide sequence ID" value="XM_024851315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRU1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRU1"/>
    <dbReference type="GeneID" id="36559014"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452917"/>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="152" mass="16887" checksum="EC12D1E75048462B" modified="2018-02-28" version="1">MSSDDKFQQLHAQLYNEGLKVRRAVVGDSYVDRSLANGSSEFARPGQELVTEFCWGHIWTRPGLSWKQRSLLNLGMLIAMKAWPELAAHTRGAINNGLSEKEISETVLHATVYCGMPAGVQAMQITEKTINEMVEKGEYTRPTSSRTSGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSE4</accession>
    <name>A0A2I2GSE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_471188</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711092.1">
        <property type="nucleotide sequence ID" value="XM_024852816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSE4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSE4"/>
    <dbReference type="GeneID" id="36560514"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471188"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06922">
        <property type="entry name" value="ChtBD1_GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014112867" description="chitinase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="212"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB55790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1242" mass="135216" checksum="B21BF8C177AD5EEB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSF8</accession>
    <name>A0A2I2GSF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fermentation associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_453059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711109.1">
        <property type="nucleotide sequence ID" value="XM_024851329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GSF8"/>
    <dbReference type="GeneID" id="36559028"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453059"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="870"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="2442"/>
            <end position="3179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3180" mass="356655" checksum="F78E95E34670392C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSM8</accession>
    <name>A0A2I2GSM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_443582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711191.1">
        <property type="nucleotide sequence ID" value="XM_024850562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSM8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSM8"/>
    <dbReference type="GeneID" id="36558261"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443582"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="485" mass="55706" checksum="B6B0D6A88EED4108" modified="2018-02-28" version="1">MGSIPDIKLPYLGLSLLWAPVLAITFLIWRGIFNIYFHPLSKYPGPRLAALSHFCQSYWTFTGTLHSKLKDLHDQYGEVVRIGPNMLVYRNAQAWKNICGHRKSGDGGPMLLEADDANHSRQRRLLAHAFSDRALREQEPTLRYYVDLLMRQLNDSAASNEAVDVTKWFNYITFDIIGDLAFGEPFACLKNKGYHPWVASIFQNAKGGCLMRPFRTMLPSSLLSILMPAKLTQMREKHQHFSREKVRERLSRQTTRPDFWTYVLRHNDEKGMTVNEMEANADLLIIAGSETTASVLSGCVYYLLKNPAVHQKLLYEIRGAFDKDEDINLMSIGKLSYLHAVLEESLRLYPPVPAILPRRVPQGGALINGEFVPEQTSVSVAWYSSFRASTNFTDPDAFLPERWLLDNKDPRFASDKKEVLQPFSYGPRNCLGKNLAYAEMRLIATKLLWNFDMAFEEECERWDEQKAYNIWEKPPLNVKLTPVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR35</accession>
    <name>A0A2I2FR35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pumilio-family RNA binding repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_459610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698400.1">
        <property type="nucleotide sequence ID" value="XM_024851880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR35"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR35"/>
    <dbReference type="GeneID" id="36559578"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459610"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="468"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="531"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="567"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="759"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="868" mass="95131" checksum="A1158B82CF8439A5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRG7</accession>
    <name>A0A2I2FRG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_419063</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698530.1">
        <property type="nucleotide sequence ID" value="XM_024847261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRG7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRG7"/>
    <dbReference type="GeneID" id="36554960"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419063"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000007">
        <property type="entry name" value="Lysosomal beta glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000009">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF117">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014197826" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="697"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB43228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="778" mass="85376" checksum="BA5A564290B7D342" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRH6</accession>
    <name>A0A2I2FRH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_370025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698534.1">
        <property type="nucleotide sequence ID" value="XM_024844938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRH6"/>
    <dbReference type="GeneID" id="36552638"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370025"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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    <sequence length="821" mass="89551" checksum="74767DCB27E33877" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 23096</strain>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
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        <location>
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            <end position="916"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="922" mass="99169" checksum="397001C978FB5FDB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS02</accession>
    <name>A0A2I2FS02_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_514614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000011">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024855226.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1392250.A0A2I2FS02"/>
    <dbReference type="GeneID" id="36562932"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514614"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="37"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="464" mass="51117" checksum="035F49062B9AB6DD" modified="2018-02-28" version="1">MNGDESTPRFNPQGIPAAPIDPLYSLVSAYEADTSANKVDLGVGAYRDENAKPWILPVATEIYNKDTTQDHEYIPIAGLPEFNCAAQSLILGADSIAIKEKRVCSFQAISGTGALHLGGLLISKFTPRPSPLVYISSPSWPIHDQLFATVGLPVKHYPYFRKDTKTFDSKGMRDALNSAPNGSIVVLHACAHNPTGVDPTEDEWKEIAQVMKARDLFPFFDCAYQGFATGYLSQDNFAIRHFVDQGFQLAIAQSFAKNLGLYGQRVGAFHFVTAPGVDAQSTTQHVASQLSVLQRSEISSPPIFGAQIASVILNDPQLFAEWEEDLLTMSGRIKKMRKCLKEELDCLETPGTWDHIVNQIGMFSFTGLTHDQVLELREKWHVYMAETGRISVAGLNDKNVAYFARAVDDVTHANMDKQSKIVIIGAGIFGLSTAYQLASEGYRNLVVLDRHMPPVRKLSALFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS52</accession>
    <name>A0A2I2FS52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_481384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698738.1">
        <property type="nucleotide sequence ID" value="XM_024853864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS52"/>
    <dbReference type="GeneID" id="36561562"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_481384"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="83" mass="9441" checksum="77D6B9067A000136" modified="2018-02-28" version="1">MPKDKHTCFVCGFRSHVKRDCPVLRSNKPYQRLLRRRPRPRTLSQATKTETKKARSAAASLPPAVGKPSSTEKAKVKWTSCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSF7</accession>
    <name>A0A2I2FSF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Geranylgeranyl pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_393296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698838.1">
        <property type="nucleotide sequence ID" value="XM_024846014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSF7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSF7"/>
    <dbReference type="GeneID" id="36553713"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393296"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="395" mass="44218" checksum="E249C0DCA4629811" modified="2018-02-28" version="1">MSSSESSSFHPPTSIPPRTSSAGMVDCIHSHPYLSRIFNGLTAIPETGRLSMNGDSLQTNMDPSRRHTRNVSSLDGTKHKDGQWSHENERILMGPYDYMVQHPGKDIRRQLINAFDAWLKVPSESLVIINKVVAMLHTASLLIDDVEDDSVLRRGIPVAHNIFGTAQTINSANYVYFLALQEVQKLNNPTAINIYVQELLNLHRGQGMDLFWRDTLTCPSEEEYLEMVGNKTGGLFRLAVKLMQAESSTGKDCVSLVNVLGLIFQICDDYLNLSNTTYTKHKGLCEDLTEGKFSFPIIHSIRSNPKNLQLINILKQRTKDDEVKLYARSYMESTGSFTHTQEVVRDLHKKALKLIDDIEASGTGKNPEGRDDGEMVRLILNKITEATLNADGPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSI8</accession>
    <name>A0A2I2FSI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hscarg dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_417806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698907.1">
        <property type="nucleotide sequence ID" value="XM_024847180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSI8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSI8"/>
    <dbReference type="GeneID" id="36554879"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_417806"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="340" mass="37221" checksum="910D7F19F555E138" modified="2018-02-28" version="1">MPASPRTISVFGATGLQGGSVVRSLLRDKISSFKVRAITRDTSSEKAQTLHRLGAELVQADGWNQGEVRDAVSGSWAAFVNTNSDDPIFLNPEGPTEFELGKSIIDGICSARVKNVILSTMKPAGEATGGKLAIRTMDMKARIECYAKQTGNFDTICSVHAGWYYEFFLSETMAHLHSGFPYHPDREGYLSLHLPRWGDEKDEGVPFLATADDFGDIVHGMLLDIEASNGKHIQGVSEIFTLPEFVDIYARVTGEKARYVPLPSWERLGEGIPEMEDARLLFAYGELTGGRYFGNEPSSTAEAASLKRLAASAQGKDGGDLQLTTLASFFERHFKNNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT97</accession>
    <name>A0A2I2FT97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_480783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699133.1">
        <property type="nucleotide sequence ID" value="XM_024853811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT97"/>
    <dbReference type="GeneID" id="36561509"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480783"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="134" mass="14963" checksum="CD8673E0906E45FB" modified="2018-02-28" version="1">MSKADDYSLLISFVINTVSENMIHAVNTTSINAPFDVSEWDLSGFREAPRKTVQPVRVQESGISVEGKVVDNKEFAEFANPGKTPNVVVFIQATRFWIWEDAVNKELNHIDLEEFRPLAQLGGVTYGTCSLTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTC5</accession>
    <name>A0A2I2FTC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_393946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699192.1">
        <property type="nucleotide sequence ID" value="XM_024846038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FTC5"/>
    <dbReference type="GeneID" id="36553737"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393946"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="77"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="6">
        <location>
            <begin position="643"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="7">
        <location>
            <begin position="873"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1214"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1312" mass="148062" checksum="D804A8B7BD78E364" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTF5</accession>
    <name>A0A2I2FTF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_418244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699159.1">
        <property type="nucleotide sequence ID" value="XM_024847208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTF5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTF5"/>
    <dbReference type="GeneID" id="36554907"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418244"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="230"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="743" mass="83962" checksum="81225941686B6173" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTI8</accession>
    <name>A0A2I2FTI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_480886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699244.1">
        <property type="nucleotide sequence ID" value="XM_024853822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTI8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTI8"/>
    <dbReference type="GeneID" id="36561520"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480886"/>
    <dbReference type="OrthoDB" id="4138941at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="327" mass="37880" checksum="726CFED959DB92E4" modified="2018-02-28" version="1">MSYKWAEFFLQGCEPNIFNLYNQPILDPEDFKQFHCDDAWKLGRRMRDDMPGMHSIMVLRLRVNGRAKLVTKTVHTQNESRAYEHILRNCPPSKLSYFPTYYGVVLNLTREKYPMSYALRPRALVLERVSPAICSRRLLGESPRPSSSLFESFVTKIGDLPLSSFEKEWYISLSIDQLQRLAALHDIGILHHDICDEHFRMPHDFYDTVLYHFSHSYTIHTPWPYVRRPKPLVELIRIEQEEVLSGVLGRARKSDLRDNVATTLDVTPVTVLNFCSQELEDTENNLELISLKTKHRPDGTVYASIPDVNISILGIDSPESFSSMAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU97</accession>
    <name>A0A2I2FU97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_467944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699522.1">
        <property type="nucleotide sequence ID" value="XM_024852506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU97"/>
    <dbReference type="GeneID" id="36560204"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467944"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB44220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="324" mass="36153" checksum="078B245FC4D2FD51" modified="2018-02-28" version="1">MVRVVVAGGTGGMSNKSPKEIITAIIESGKHTLTVWTRSANSSKHNLPGVTYEQVNYDDKDDMVKKLQGVHSVLCFISQPTVQIALVDACIAAGVKRYAPNEWAARSNSGSFAYHEKDQVHEYLQEVNRKEKVLEYSLFQPGLFTNYLSAPIQSASYCPIWTNQWDIANRRAIVPAERDWQLSTTTIQDLGKVVAEALAYTGEWPEIGGITGTKTSSSEIIKTAEKIRVLTPELPLGPFKIDEVSTENLRAGKLGASWNPLLPEFETTDPNYDRVKYSEYVVAQIILGGLDGAWSTSDEWNKLLPHLKLTTVEEFLLRYWGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUP4</accession>
    <name>A0A2I2FUP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_416935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699662.1">
        <property type="nucleotide sequence ID" value="XM_024847151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUP4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUP4"/>
    <dbReference type="GeneID" id="36554850"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416935"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="385"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB44360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="590" mass="62227" checksum="AAE3852942221634" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV37</accession>
    <name>A0A2I2FV37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_513647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699773.1">
        <property type="nucleotide sequence ID" value="XM_024855132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV37"/>
    <dbReference type="GeneID" id="36562838"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513647"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-alanine--D-alanine ligase C-terminal" evidence="1">
        <location>
            <begin position="126"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="369"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59144" checksum="0C75E6F6BC3FECEA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV52</accession>
    <name>A0A2I2FV52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_513688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699822.1">
        <property type="nucleotide sequence ID" value="XM_024855137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV52"/>
    <dbReference type="GeneID" id="36562843"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513688"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF60">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="534" mass="60730" checksum="384A272BC456FF4F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV87</accession>
    <name>A0A2I2FV87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_450624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699857.1">
        <property type="nucleotide sequence ID" value="XM_024851138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV87"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV87"/>
    <dbReference type="GeneID" id="36558837"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450624"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF4">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="284" mass="31879" checksum="715CB617BEF81BAF" modified="2018-02-28" version="1">MDQTFQPTPSAPVIRLMVLETDKPHPDTYSQRGSFGRIIYEHFSRAGREHRPPLGVETDQVFVVTEQGGRMPSAAEFDRFDGLLITGSVYDAHANNDWILQLLSLLRTLWIQRPDFHFLGVCFGHQLLARLLGGSVGPAPSQDWELGHCRIDLTPVGQHIFHTRNDHVHLHQMHQDQVVTAPTAASAGLAHLPDDTEIACWGRSDHTPIQGLYIPNRLFTTQAHLAFDEDMVKRQIQIRVDAGGIKDLEHADRAAETAHLEHDGVEVAKAILRSFVYDRDDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVC0</accession>
    <name>A0A2I2FVC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_513733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699874.1">
        <property type="nucleotide sequence ID" value="XM_024855144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVC0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVC0"/>
    <dbReference type="GeneID" id="36562850"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513733"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014196280" description="DUF676 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55513" checksum="4AD6221A457C704D" modified="2018-02-28" version="1">MLHSNTTTPYALLSISTILILSATMDPIPIFTASRPTDTQDPPLPYTASPWRLLLSDLRLAKQFYRHIPQMFRPLRDSDGPIAELNLTWENLWVILVHIILIFYQVGFLISLPVLSFFCLMPAPFLLPYIWLAFKVNKVICRWTLNRGDRILHSTYMLPENPPWPREHERWIFLNGIAVGTHWMQNSLNRLSQIFFRPVRGIHTPTAGIVFDLIKCLIQRNFCYATQDVRDAYEIIKETLWDDGCHKLILIAHSQGGIATSLIVDWLVGEISQGHLQKLEIYTFGNAANHFNDPRRLFPGEDGRVGEPRPKDRGPAAGQYQNVSRVLHEQGEQQMANVGRGRGFSVPERGQQTASPRPPALEVIEVGAPMWQRAPFIEHYANSDDFVCLWGVIHFIRMRNRYLGHLFLRQSPGHLFVQHYLDPMFPLDNGEVTIGVNDFFHLVAMAPISALESERCGWTDPGWHLSRLWRYRNGRSPLDHYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVC6</accession>
    <name>A0A2I2FVC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-galactosidase B</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Lactase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_367836</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699900.1">
        <property type="nucleotide sequence ID" value="XM_024844825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVC6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVC6"/>
    <dbReference type="GeneID" id="36552525"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367836"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.390.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000138">
        <property type="entry name" value="Probable beta-galactosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014122685" description="Probable beta-galactosidase B" evidence="17">
        <location>
            <begin position="21"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="18">
        <location>
            <begin position="402"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB44598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1017" mass="111315" checksum="230E911B8A8B0E82" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVC7</accession>
    <name>A0A2I2FVC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_367532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699859.1">
        <property type="nucleotide sequence ID" value="XM_024844810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVC7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVC7"/>
    <dbReference type="GeneID" id="36552510"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367532"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="340" mass="37302" checksum="F7541C7671DDC831" modified="2018-02-28" version="1">MVNHREFTVYDYTVGVICALDKELLAVRYLLDSTHPEVKVHPRDTNTYTLGTLSRHGIVATCLPVAEYGTNSAASVASQMYMSFPAMQFCLLVGIAGGAPSKEDIGLGDVVVGVPTGTRSGVIQYDMGKATPEDCFLETGSLQRPPRVLLSAINGLRSNPTLTINPLQAFLETIAQQDPKYAFLGREYDILFPRGCVHAPSEANCEGHLGLKVQRPARSFEYPCIHYGLIASGNKVIRDAVLRDRLADQYGFLCFEMEAAGILNVLPSLVIRGICDYSDSHKSKIWQDYAAAAAAAYAKLLLSQVRVYDAPYPGETKMIDIRCVLTPGTFWHDSLMNKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVF7</accession>
    <name>A0A2I2FVF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_440833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699889.1">
        <property type="nucleotide sequence ID" value="XM_024850175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVF7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVF7"/>
    <dbReference type="GeneID" id="36557874"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440833"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="338" mass="36396" checksum="E3040DDB8C792D4B" modified="2018-02-28" version="1">MSASLPGNRDLPPSQYDLSTYWGRVRHAADISDPRRTLFVSSSGLEQAKSLVSSYKQSLVPGMTPDLWRAKKVVDATLHPDTGEPVFLPFRMSCYVLSNLVVTAGMLTPGLQATGTLMWQIANQSLNVAINNANANKSTPLSVSQMTKSYLMAVSASCSVALGLNALVPRLRGISPNTKLILGRLVPFAAVASASALNVFLMRGEEIRQGIDVYPVLSEAEKAKREETGEAVQSLGKSKKAATLAVGETAISRVLNATPIMVLPPLILVRLEKTAWLKARPRMIMPLNLGLVLTTSLFALPLALGAFPQRQAISAQSLEEEFHGRGGKEGQVEFNRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVZ2</accession>
    <name>A0A2I2FVZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_267072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700103.1">
        <property type="nucleotide sequence ID" value="XM_024843123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVZ2"/>
    <dbReference type="GeneID" id="36550822"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_267072"/>
    <dbReference type="OrthoDB" id="4507551at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="115" mass="12607" checksum="7B462728E2F34822" modified="2018-02-28" version="1">MSLRSTLSIPTDDTDNSGPALSLSPPARKPATRKDRRITRKGKELQRKHLRENQTVVRWMPDGNGFLVSKAFNVRVLGMDRMLTVTVPVSWRGVGGVVVLGAVVLGYLGFGRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW91</accession>
    <name>A0A2I2FW91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_440084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700179.1">
        <property type="nucleotide sequence ID" value="XM_024849987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW91"/>
    <dbReference type="GeneID" id="36557686"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440084"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="65" mass="6861" checksum="80ABD76F8971F85F" modified="2018-02-28" version="1">MKFNIPLFPIPIVSQSACTLQGPSPVELGPRACLSLAHPNLVLTSMKNGLGIGWDGSDGLVVCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWC7</accession>
    <name>A0A2I2FWC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_513053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700242.1">
        <property type="nucleotide sequence ID" value="XM_024855056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWC7"/>
    <dbReference type="GeneID" id="36562762"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513053"/>
    <dbReference type="OrthoDB" id="4490648at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014118489" evidence="1">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="102" mass="11073" checksum="CB4E3221BCFC0E4C" modified="2018-02-28" version="1">MRFTLFSTTAMALFACVPAAPITPRSSSILLNWTKESAIKTVNSLMGQLPMDAQIWKVDEDSGLVGVNFNLDMEELAKTGLVSLSKHKNANINMNVTISGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX27</accession>
    <name>A0A2I2FX27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_479684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700464.1">
        <property type="nucleotide sequence ID" value="XM_024853706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX27"/>
    <dbReference type="GeneID" id="36561404"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479684"/>
    <dbReference type="OrthoDB" id="3920481at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="95" mass="10541" checksum="9D787A114667E1E7" modified="2018-02-28" version="1">MSSPSVQVQPQPSTKGVVSPDAGPKGMNFDIVRCSRCQRSMSLENESSPGVVRFGMNSYYCSRYPRNEENRNKHHDEHTLFAVSLLAITAATSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXK3</accession>
    <name>A0A2I2FXK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_413453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700661.1">
        <property type="nucleotide sequence ID" value="XM_024846979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXK3"/>
    <dbReference type="GeneID" id="36554678"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413453"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="62"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="348" mass="38260" checksum="620D2A348286CD87" modified="2018-02-28" version="1">MEDPNERHSPEVFAPADLFVPPNIDRARLFAGESYAYYSPCPSETDPEFESSSPTRSSSRTNYVLGVDEAGRGPVLGPMVYSAFYLPHDLHHPILAQQYSFDDSKVLTPAVRANLMETLCTPGTPLFQSSGWATKILSARDISSGMMRLGTGAYNLNAQAMDATIELIQNIVEVKKVDIREVYIDTIGNPAVYQQKLERIFPSLRITVAKKADSLYPCVSAASVAAKVTRDVALELCHQNVLVAQAPQNASHQNATESWGSGYPSDSKCVRWLRRNMDPIFGWSNECRFSWGTAKEMLELKGGSKVDWPVDGNNSQLREFMLASSSGNGGTAAHELGQWFGSKPTEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXL3</accession>
    <name>A0A2I2FXL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_449085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700676.1">
        <property type="nucleotide sequence ID" value="XM_024851015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXL3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXL3"/>
    <dbReference type="GeneID" id="36558714"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449085"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="438" mass="50057" checksum="DF7B4B34449A2CCD" modified="2018-02-28" version="1">MSLSRPYIPLRRSLGPLSSRTCRTPRSFHGSFRKYSSEQKPREPKPFTVWRPYLRLAIGVPFIGALIYSMMTGDVTELDSPSIVELDEALKKQSTISETSPMRLRMEKLIKEHQQKIVEELSKIDGKEFKADTWTRPNGGGGISCVLQDGNVFEKAGVNVSIVYGELPRPAIEKMRADHKSFVGADVDSLSFFAAGLSLVLHPHNPMAPTVHLNYRYFETSDPKDPINGDKNWWFGGGTDLTPTYLFPEDAKHFHQTIKDACDRHDATYYPKFKAWCDKYFYLPHRREARGVGGIFFDDLDANFLESSSSSSQNPQETLFSFVSDGLASFLPSYIPIIERRKDMPFTPAQKEWQQLRRGRYVEFNLVYDRGTSFGLRTPNARVESILMSLPRTASWAYMDPVSGTRTETSGVEEEQLGEEKDREKEIMDVLRHPRQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXS1</accession>
    <name>A0A2I2FXS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_365168</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700731.1">
        <property type="nucleotide sequence ID" value="XM_024844688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXS1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXS1"/>
    <dbReference type="GeneID" id="36552388"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365168"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB45429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="456" mass="52090" checksum="15AFC70AA7714AEE" modified="2018-02-28" version="1">MSKSRRNVRFQHRASNGSENRRPSISDASDVVSEPGSPSKNGGVSKQATIPEEKSKKPQLSEYEKKRQTFITRTIWTFVMIAGFFISMFSGHIYIIGLISAIQIVSFKEVIAIANVPSREKNLRFTKSLNWYFLATTMYFLYGESVIYYFKHILLVDKVLLPLATHHRFISFTLYVMGFVFFVGSLQKGHYRFQFTQFAWTHMALYLIVVQAHFVMNNILEGMIWFFLPASLVITNDIFAYVCGITFGRTQLIQLSPKKTVEGFLGAWICTIIFGYFMTNVLMRYKYFICPVNDLGSNVLTGLECTLNPAFVPQPYSFPFPEWTGLDKIFYVEPMQFHILVFASFASLIAPFGGFFASGLKRTFKIKDFGESIPGHGGITDRMDCQFIMGFFAYMYYHSFIAVYKASVGDIIETAINGLTVEEQLEVVRGLGKYLYNQGTVSETILDCLTTELKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXS2</accession>
    <name>A0A2I2FXS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_512118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700722.1">
        <property type="nucleotide sequence ID" value="XM_024854958.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FXS2"/>
    <dbReference type="GeneID" id="36562664"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512118"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000817">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="7">
        <location>
            <begin position="538"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1377"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1023"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1385"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1539" mass="165963" checksum="13D5FD2A8C5A7709" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY01</accession>
    <name>A0A2I2FY01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spc7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_512189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700811.1">
        <property type="nucleotide sequence ID" value="XM_024854965.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FY01"/>
    <dbReference type="GeneID" id="36562671"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512189"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01315">
        <property type="entry name" value="Spc7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1555" mass="169325" checksum="6107FD7D5ADBFDA5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY04</accession>
    <name>A0A2I2FY04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P170DRAFT_478429</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700768.1">
        <property type="nucleotide sequence ID" value="XM_024853559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY04"/>
    <dbReference type="STRING" id="1392250.A0A2I2FY04"/>
    <dbReference type="GeneID" id="36561257"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478429"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="21">
        <location>
            <begin position="71"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="22">
        <location>
            <begin position="519"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="655" mass="72570" checksum="17740D7E19B31139" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY11</accession>
    <name>A0A2I2FY11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_245257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700814.1">
        <property type="nucleotide sequence ID" value="XM_024842979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY11"/>
    <dbReference type="STRING" id="1392250.A0A2I2FY11"/>
    <dbReference type="GeneID" id="36550678"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_245257"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000025">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="340"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="629" mass="69406" checksum="1D57FE3EADD85659" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYN7</accession>
    <name>A0A2I2FYN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUR7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701044.1">
        <property type="nucleotide sequence ID" value="XM_024849840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYN7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYN7"/>
    <dbReference type="GeneID" id="36557539"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439468"/>
    <dbReference type="OrthoDB" id="5419460at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="246" mass="27340" checksum="B89DC016D984B898" modified="2018-02-28" version="1">MPLSRAALGFLGLFFTASALLLMFLTILGGAKNSNPLNQIYLLQVDTSNIPGAPDLSRWTFWNLCRVDADGKSQCGKSYPDFPFDPPSHRNFDTTTNIPPEFIGSKHYFLTSRFIFPFLLIALFFAVVSLFTGFLAMCTRIGSYLSSLMAWVALFFQIIATSLMTAVFVQGRNRFSANGQVAKLGVKSFAFMWTAVACLLLSCVLYCMGGAVGRQEKGYSGREHRRRGFFSTQRSHSVRSNKEANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ44</accession>
    <name>A0A2I2FZ44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_458124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701215.1">
        <property type="nucleotide sequence ID" value="XM_024851768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ44"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ44"/>
    <dbReference type="GeneID" id="36559467"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458124"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000009">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000056">
        <property type="entry name" value="Sister chromatid cohesion protein Eso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="46"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="518"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB45913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="663" mass="74803" checksum="00E631E2A000AC09" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZU6</accession>
    <name>A0A2I2FZU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_439821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701446.1">
        <property type="nucleotide sequence ID" value="XM_024849926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZU6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZU6"/>
    <dbReference type="GeneID" id="36557625"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439821"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="971" mass="108774" checksum="A9C10AD49D6E9F9F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G078</accession>
    <name>A0A2I2G078_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_365306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701576.1">
        <property type="nucleotide sequence ID" value="XM_024844696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G078"/>
    <dbReference type="GeneID" id="36552396"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365306"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="505" mass="56034" checksum="FA8BF2043A7E584E" modified="2018-02-28" version="1">MPSDNEIHSAGEVTHEFTTHGPGKDVDIAVKFLIDLDPAVRARPIAPDEARRVLWKIDLILIPLITVTVILAAVDKVIISNAAIYGMSADTNLVGDQYSWVGSIFYFGYLAAEWPAAFLIQRLPVAKFYAACILGWAVILLCTAATQNFAGLAVTRFIMGMLEAVVFPISSIVTVMWWKTQEQPIRVAFWFNQLSSVFAGIVSYGIGHAHASLRPWRLLFLVLGGFSVLWAIVIFVFLPDSPIKCWYLSDREKLICLERVKDNNTGMEDKRFKWHQVKECLTDPKTWLLAIFSCAQNIPNGGLVTFSAIIVSGLGYSTLITTILGIPTGVLATIWQLMLSFIASHMRNSRCVIIALSNVVPMVCAILMWKLPQSNQHGLLAAYYVFYTYWAPYVLSTSLPMANTSGHTKKLTMNAIFFLAYCVGNIIGPQTFQSSDAPSYAHGYSGLLGCIVAAMVSISAYGALCYWENKKRDAEQAAIATASVVEFQAFSDQTDKEKRDFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0P3</accession>
    <name>A0A2I2G0P3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_457085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701735.1">
        <property type="nucleotide sequence ID" value="XM_024851680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0P3"/>
    <dbReference type="GeneID" id="36559379"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457085"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="679" mass="75145" checksum="988157DF0C028827" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0T9</accession>
    <name>A0A2I2G0T9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_511260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701807.1">
        <property type="nucleotide sequence ID" value="XM_024854868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0T9"/>
    <dbReference type="GeneID" id="36562574"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511260"/>
    <dbReference type="OrthoDB" id="4447675at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="93" mass="10291" checksum="59337E51361F46BA" modified="2018-02-28" version="1">MDLAQKHGHLKTESRNPLESQQPHVDNQSEVNNLLGSFGHPQNDHPDRRSSGAGNMGNLVQKAREMTGRNSGDISDRKNSQSEAGFDGVREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1E4</accession>
    <name>A0A2I2G1E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_411934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701999.1">
        <property type="nucleotide sequence ID" value="XM_024846917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1E4"/>
    <dbReference type="GeneID" id="36554616"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411934"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000484">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000037">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="551" mass="60044" checksum="3A40052D7CCC2534" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2M2</accession>
    <name>A0A2I2G2M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_457496</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702418.1">
        <property type="nucleotide sequence ID" value="XM_024851724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2M2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2M2"/>
    <dbReference type="GeneID" id="36559423"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457496"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000299">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="259"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="428"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB47116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1134" mass="125536" checksum="C2089A2374A4F083" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Y2</accession>
    <name>A0A2I2G2Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitin deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_438936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
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        <property type="protein sequence ID" value="PLB47236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702538.1">
        <property type="nucleotide sequence ID" value="XM_024849721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Y2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2Y2"/>
    <dbReference type="GeneID" id="36557420"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438936"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10958">
        <property type="entry name" value="CE4_NodB_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="71"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="268" mass="30593" checksum="57956F4018EA4AD9" modified="2018-02-28" version="1">MLLRLPRRKLRRLLIMLLPFLLTLLLLTPFYIIYKPPNLLIRYFQHRWPDVLFHLPPPPNHHASSTEGRQKLIALTIDDAPSPHTLEILDLLSHHDAHATFFLIGSQIPSREESLHELLRAGHELANHAMRDEPSRALSPSDLEAQILSVQDSIRAAYSVVGLREPAGKYFRPGSGFFSAAMRDVVRKLGFRIVLGSVYPHDAQIPWWWVNARHVLSMVREGSIIVCHDRREWTVPMLGVVLPELKRRGYRVVTVSELLNGVEGGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3Q3</accession>
    <name>A0A2I2G3Q3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_360752</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702803.1">
        <property type="nucleotide sequence ID" value="XM_024844433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3Q3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3Q3"/>
    <dbReference type="GeneID" id="36552133"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360752"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="41"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="317"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB47501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="489" mass="54771" checksum="71D0E2B61F1B3BDE" modified="2018-02-28" version="1">MAASTSTLSDPQEYQKIFHWAETQKDGAIPSFNTRRNDPYEYQSGFGNSFMSEAVPGTIPHGQNSPRHVRFGLYAEQLTATAFVAPRHANKKAWLYRARPAVAHQGFTDLPDNKDTESNFLPLNPRVHVSPTQLAWHPFDIPRGEEVDFVSGLKTVAGSGDPTLREGLATHVYTANTSMTKKAFVNSDGEFLIVPQQGALDIQTEFGPLFVQPGELVVIQRGLRFRVELPDGPSRGYILEVWGTHYELPELGPLGANGLANPRDFLSPVAQYEIAQEPWEILYKLGGKFFKSTQNHSPFDVVAWHGNYVPYKYDLTKFVNVGSISVDHIDPSIFCVLTAKSRDLTAPLADLLIFSPRWDVASHTYRPPYYHRNVASELMGLIYGDYGGRSDAFKPGSISFECGMVPHGVAYEEFKAASENPPPVARISEASIAFMFESSRPFTITDYAWTSDKRHEHEPKMWDSLVDNFSKHKDEVEELLARKAKGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3T2</accession>
    <name>A0A2I2G3T2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_385290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702837.1">
        <property type="nucleotide sequence ID" value="XM_024845717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3T2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3T2"/>
    <dbReference type="GeneID" id="36553416"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385290"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="415" mass="47419" checksum="A7908EAEA1FAECE9" modified="2018-02-28" version="1">MSDDEADPELLALLRKSLGLGGGPANPQAAETKVLENAQYVFDNAIDVALTPASVKAAAETIWRQMQKKGYSTQTWSQHELHPKTKDEATVDFVFTMDLLNFSFWSELPDEKRFAIEYRGRKWTGYWSLVAALQRALDEEIPITTPEFWANEDECTESLLRHVFRSATDEEIPLLKERLECLQEAGRVLCKDFDGSFLNCIYSSSRSAAALVNLLAENFPCFRDETSFQGRRVRLYKRAQILIADLWACFNGEGFGEFHDIDKITMFADYRIPQMLHQLGCLRYSPPLESHIRNQKVIPSGSTWEVELRATSIWCVELIRREIELRHPEAKTLLVPAPVDDATSDGPSQHLQAPATQDEQEKCSTQKRRNKSVHETKGPGLNAILIDFFLYDTMKELESDGQESIPHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3U6</accession>
    <name>A0A2I2G3U6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702856.1">
        <property type="nucleotide sequence ID" value="XM_024849354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3U6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3U6"/>
    <dbReference type="GeneID" id="36557053"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437386"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="223" mass="25366" checksum="9886C9DD78FD32A7" modified="2018-02-28" version="1">MISKSAPSFTFVPVNLADPKEYSEFQRQRTICGWAFSDETLAFYREKQEQKLKSLFWITITNPGASSAETPNAESEPAESTLRVGHISLDSYTDPPHSPEIVAEDKSTLAIQNFFILPEHRKLGLGHAVMEKLEDVARTEPYGSPNCQFLALSTLTKKYVYDEGPEWRGLWAKFGLPAPDFSAHTWYEKRGYEMFKEEPRYPVTNEDGFTALLVMALMKKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4A3</accession>
    <name>A0A2I2G4A3_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_456490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="STRING" id="1392250.A0A2I2G4A3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456490"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="660"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <end position="89"/>
        </location>
    </feature>
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    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="237"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="297"/>
        </location>
    </feature>
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    </feature>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="430"/>
        </location>
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    </feature>
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            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="660" mass="70251" checksum="68FCBD2EC71ED63A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G575</accession>
    <name>A0A2I2G575_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thioredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_410563</name>
    </gene>
    <organism evidence="10 11">
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024846851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G575"/>
    <dbReference type="STRING" id="1392250.A0A2I2G575"/>
    <dbReference type="GeneID" id="36554550"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410563"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014189399" evidence="8">
        <location>
            <begin position="21"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
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            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="239"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="719" mass="80318" checksum="82E5EB11870893AF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5U9</accession>
    <name>A0A2I2G5U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_208403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703525.1">
        <property type="nucleotide sequence ID" value="XM_024842798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5U9"/>
    <dbReference type="GeneID" id="36550497"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_208403"/>
    <dbReference type="OrthoDB" id="4503514at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="295" mass="34129" checksum="B9EFF78337745378" modified="2018-02-28" version="1">MKPMRPAELTETNFRAHQLDLQDYKDTRNNIAKVEEAIKSSIAIHIQPLIEEKRRFEILKVLKEQYEPTEDEMEEKALRQYKAVIKRSPRKGKINAWIEDFDHAYLAIKRLNMSESQDKHVQKDFLRSIEAVDPLYSRLHYSNIRNTTYRNLLSDFRTYLANSGRDDDSAVAHNFATFNGQGDKPADAEKPQDAGKKGEGSSPYCVCGLRHRMEKCWQLYPDLRPPNWKLNSKAMKKLKDFAAGSSTQAQMVRSIIEKNWKQGDERPQEYHVMALSFSASLDIPLKNCFIIDTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5Z4</accession>
    <name>A0A2I2G5Z4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_209775</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703591.1">
        <property type="nucleotide sequence ID" value="XM_024842809.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G5Z4"/>
    <dbReference type="GeneID" id="36550508"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_209775"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="245"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1510"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1575"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1603"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1687"/>
            <end position="1746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB48289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1746" mass="192812" checksum="89BAFF2034DF7975" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6P7</accession>
    <name>A0A2I2G6P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703848.1">
        <property type="nucleotide sequence ID" value="XM_024849517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6P7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6P7"/>
    <dbReference type="GeneID" id="36557216"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438125"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812">
        <property type="entry name" value="BLR2425 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="226" mass="25465" checksum="1F855038854333D8" modified="2018-02-28" version="1">MYYEPGITEHNLPRDPFKACVIPRPIGWISTQSKDGQANLAPYSQFNNLTFDPPYVMFSSNQTVDGSRKDTVVNAEATGEFVWNLATWDLREAVNVSAQQFPYGVDEFERAGVHKERARLVDVPMVQESPVKFECRYHSTVRLPGNPPMGTVDVVIARVVAVHIKDEVLTDGILDVRKTQPIARCGYYQYAVVRDTFDMQIPGMGEVMFGLEGNARKNRTFGDKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6Y1</accession>
    <name>A0A2I2G6Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_425675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703939.1">
        <property type="nucleotide sequence ID" value="XM_024847657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6Y1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6Y1"/>
    <dbReference type="GeneID" id="36555356"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425675"/>
    <dbReference type="OrthoDB" id="4138941at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="184" mass="21853" checksum="BAC51F938ECC9437" modified="2018-02-28" version="1">MEEDPTWIDTFFSGKTPPFKVLDEPQGLTTFHFPVPDRQWIFGRRLHEHNGSPIVVFRLYAKEDGVKTSYAAKTFPEYTLNHAQEQWYRIPSTWYTTQDIKDEFDSFLNETRAFEHINRVCPEAQKIYFPRYHGILIPIDRRKFDRRFQPRNQAVILESITPDTNTRRIPCKQLTSAPAFDRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8I2</accession>
    <name>A0A2I2G8I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_446914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704494.1">
        <property type="nucleotide sequence ID" value="XM_024850839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8I2"/>
    <dbReference type="GeneID" id="36558538"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446914"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="510" mass="57743" checksum="23D9CADDDAD25271" modified="2018-02-28" version="1">MHAACWTCRNRTIQCDQTKFPCAKCEKAGLECFEQRPLRWVRGVAIRGKMRGRVLGGDLKGTNQSESKKLQRKEIVSSRVKSLAIDVAPPVALQDPCMYNLDWSSKFYLDYYNVRIAKLYILHDSKSNPFRNLLTYATDDDSPLRMGMIAVAARHFANTGRSFDQDNEVLSPRFVNANVDALHFKRKAIKALLSSLSHPEHSQKDAIMATILLLIFLDLLESGIDGWKYHLNGAEGIVKLSQSLLESGASQYVNRDPGETDEETRRFVARQLSLVSTIGGALSGSKTGPELCINFEESRHQESIVRSFLGCPSFLLRAIRYFSNQRHVIETLDMHDGISIQEHIRDTQTMLELTANFDCLEWASDSLQSSDSSKIEIQKLYMLSEAYRTAAMLYGARVLRAFTTLTGTISSGNRELVLRLLDVIDSLKCDPALFKCLLWPTFIAGLESQTDIEQKLVIESLRMLWELTCCLNVIGASNILNDYWQRTHFDESSVPKESQLYMIEQGWLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G957</accession>
    <name>A0A2I2G957_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_384196</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704690.1">
        <property type="nucleotide sequence ID" value="XM_024845671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G957"/>
    <dbReference type="STRING" id="1392250.A0A2I2G957"/>
    <dbReference type="GeneID" id="36553370"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384196"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000023">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB49388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="642" mass="69729" checksum="D1F44266E62B8F73" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9B0</accession>
    <name>A0A2I2G9B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_437036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704767.1">
        <property type="nucleotide sequence ID" value="XM_024849273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9B0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9B0"/>
    <dbReference type="GeneID" id="36556972"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437036"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="193" mass="21608" checksum="1856C0DB0CC2FAC3" modified="2018-02-28" version="1">MDPSGGPNAAALYDARRRRGSVGTSQLFDNIVSASNFDRDEVDRLRKRFMKLDKDSSGTIDRDEFLSLPQVSSNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEEKLRFAFKVYDIDRDGYISNGELFIVLKMMVGNNLKDVQLQQIVDKTIMEADKDQDGKISFEEFTDMVENTDVSLSMTLSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9D2</accession>
    <name>A0A2I2G9D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hsp70 nucleotide exchange factor FES1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hsp70 nucleotide exchange factor fes1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_437071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704792.1">
        <property type="nucleotide sequence ID" value="XM_024849280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9D2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9D2"/>
    <dbReference type="GeneID" id="36556979"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437071"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="10">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="213" mass="23164" checksum="C27EFAC241C2D827" modified="2018-02-28" version="1">MDANMNGLLKWSIQNSTNPSDPNAPTNGATDPSRGLTPEMISTLLGGPSDADLMKAAMEALHSDEVDLENKMIAFDNFEQLLEGIDNANNMEPLGLWTPLVELLRHDEADMRRMAAWCVGTAVQNNEKAQDKLLVLNAMPTLISIATSDSNPATRKKAVYAISSAVRNYQPAMDDAVKHLPEGYSREKVDAGDMEAVDAIMDKLRAHPVQTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9H9</accession>
    <name>A0A2I2G9H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">MIZ zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_437119</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704839.1">
        <property type="nucleotide sequence ID" value="XM_024849291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9H9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9H9"/>
    <dbReference type="GeneID" id="36556990"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437119"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097240">
        <property type="term" value="P:chromosome attachment to the nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16792">
        <property type="entry name" value="SP-RING_Siz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000247">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF100">
        <property type="entry name" value="LIGASE SIZA, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G05240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="14">
        <location>
            <begin position="101"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="291"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB49537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="534" mass="58928" checksum="387BC516F45A9E2D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAP4</accession>
    <name>A0A2I2GAP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13 14">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="5 13 14">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_380216</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 14">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="5 13 14"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705240.1">
        <property type="nucleotide sequence ID" value="XM_024845519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAP4"/>
    <dbReference type="GeneID" id="36553218"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_380216"/>
    <dbReference type="OrthoDB" id="4444234at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11 13 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13 14" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014125573" description="Endo-1,4-beta-xylanase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="16">
        <location>
            <begin position="58"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB49938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="246" mass="26975" checksum="D35E0B8DA58ECA7F" modified="2018-02-28" version="1">MLSFSRLLAFLPLVGVFASPADPTSKTVYPKSPEFLRWLEQAGNSTDGSQLAKRENQFSDSKDGVNSAGFYYSLYNDNGAGAKYTEFDGSGQFQVTWDVSSEFLGGKGYKGGDPRSLTWEGSFKAEGDYTLAVYGWTTDPVTEWYVVEAHGTGTPGNGNILGQVNSDGGVYDVYMIPYRDVPEIYGVTNFNQLWSVRREDRSTGTVDVSAHFDAWKQLNLEPGNPVFQMLTAEGFSGTGSLDFTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAU0</accession>
    <name>A0A2I2GAU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_435257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705306.1">
        <property type="nucleotide sequence ID" value="XM_024848900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAU0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAU0"/>
    <dbReference type="GeneID" id="36556599"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435257"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="707" mass="78704" checksum="133AFAC1C989B717" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAV3</accession>
    <name>A0A2I2GAV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_424442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705315.1">
        <property type="nucleotide sequence ID" value="XM_024847569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAV3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAV3"/>
    <dbReference type="GeneID" id="36555268"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424442"/>
    <dbReference type="OrthoDB" id="2103397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="268" mass="30764" checksum="7D0B2C6A528128AB" modified="2018-02-28" version="1">MAKIHDLDMDEMDEIGTRLVDFVEPAKASATESDAFWRPDICTHIIPSGIESHLEDYLHTLQATPMDPRLIRTRVDNILLTTFATVKDFFNRYTPNIQPVLDNVHLSFGQAVTGPEPAGDGSCCLRSIADTILWFGGTENLEANLVVQRTKYEVDGKLPPAMLILYYSRVISARNMGIYGIVTNSYKWRFVWMKCNSQYYEITLDWTNQNERNLIFDNLYHIMESAFVLAIRGPGPLIQLRSIQERSGCRIWNNKAESERAWDDYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBI6</accession>
    <name>A0A2I2GBI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_424642</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Lipid-anchor</topology>
            <topology evidence="1 11">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705533.1">
        <property type="nucleotide sequence ID" value="XM_024847584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBI6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBI6"/>
    <dbReference type="GeneID" id="36555283"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424642"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013987649" description="1,3-beta-glucanosyltransferase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="13">
        <location>
            <begin position="378"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB50231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="540" mass="58513" checksum="A03D0C988502CA88" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBU9</accession>
    <name>A0A2I2GBU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Kexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_354235</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705655.1">
        <property type="nucleotide sequence ID" value="XM_024844017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBU9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBU9"/>
    <dbReference type="GeneID" id="36551717"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354235"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014158859" evidence="17">
        <location>
            <begin position="20"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="486"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="648"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="787"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB50353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="845" mass="92800" checksum="A16924B9584A7E17" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCK5</accession>
    <name>A0A2I2GCK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_474172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705915.1">
        <property type="nucleotide sequence ID" value="XM_024853108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCK5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCK5"/>
    <dbReference type="GeneID" id="36560806"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474172"/>
    <dbReference type="OrthoDB" id="3548654at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF32">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="644" mass="72210" checksum="24CF17FD89301052" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE62</accession>
    <name>A0A2I2GE62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_406794</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706452.1">
        <property type="nucleotide sequence ID" value="XM_024846647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE62"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE62"/>
    <dbReference type="GeneID" id="36554346"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406794"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="48"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="14">
        <location>
            <begin position="527"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="599" mass="67032" checksum="EE5AF804B59DAC80" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEI7</accession>
    <name>A0A2I2GEI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_382717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706607.1">
        <property type="nucleotide sequence ID" value="XM_024845613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEI7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEI7"/>
    <dbReference type="GeneID" id="36553312"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_382717"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="573" mass="63745" checksum="A1D4EC28BB24C091" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEU3</accession>
    <name>A0A2I2GEU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_356191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706649.1">
        <property type="nucleotide sequence ID" value="XM_024844131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEU3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEU3"/>
    <dbReference type="GeneID" id="36551831"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356191"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="719" mass="80715" checksum="D8AD6695EE314A60" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFD9</accession>
    <name>A0A2I2GFD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_471531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706900.1">
        <property type="nucleotide sequence ID" value="XM_024852850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFD9"/>
    <dbReference type="GeneID" id="36560548"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471531"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="12226" checksum="55F178768B1BF3D9" modified="2018-02-28" version="1">MSYDLPQPSCDSGNFASFFDNCNKHPVNYILPENYERKDTHPFIAGGFVWTGWDYLGEPYHHTQARSSSSDALAMVRARDSGILTVRAGSEDLGSSTLTVEALSESSHIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG00</accession>
    <name>A0A2I2GG00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_350153</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707116.1">
        <property type="nucleotide sequence ID" value="XM_024843781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG00"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG00"/>
    <dbReference type="GeneID" id="36551481"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350153"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="202"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB51814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="656" mass="74379" checksum="F606B35D7D0A8F91" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGA2</accession>
    <name>A0A2I2GGA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 1-aminocyclopropane-1-carboxylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_377221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707204.1">
        <property type="nucleotide sequence ID" value="XM_024845394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGA2"/>
    <dbReference type="GeneID" id="36553094"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_377221"/>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="46"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="402" mass="43375" checksum="622C700E8A0AD96C" modified="2018-02-28" version="1">MCFSLPEAFAKIPRHPFLYSHPSPIHPLPALSTLLTRTHHHPTTNAPSISLFAKREDQCSPLACSGNKYRKLEYIVPHIQRGCAHQPDGTDIPDVTPTTLVTEGAVQSNHTVQVAAVATQLGLDAVVVLHKSTGGGLASTTDAPAFLRTGNVQVDRLLGADVRLLESDNVADDGSDPIAPIMADLWRRGKVPYWIPSGASLHPLGGLGYARCAFEIAEQEEEQLGGEGRRFDYVFVACGSGSTVAGLIAGFKLLEKMEVRRTGASLGTSSRRVIGILNSPTKPREYHEGRVLQFARRAAVQIGLDAEDITADDVRLDDRFAGTGYGVLDPKTKETLALMAQREGVLLDPVYTAKVARGMAHWVQQGDIARDWPSQSRDPHPINALFIHTGGQSALGAYADVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGF8</accession>
    <name>A0A2I2GGF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_328718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707273.1">
        <property type="nucleotide sequence ID" value="XM_024843354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGF8"/>
    <dbReference type="GeneID" id="36551054"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_328718"/>
    <dbReference type="OrthoDB" id="3449024at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="199" mass="21619" checksum="60CBDB83E9E16FAC" modified="2018-02-28" version="1" fragment="single">WMRCSVLAGSLSGLTFLFGVVAPMLLPPPSPSSDAVTIHAFYHAHRTGNAAGAFLLMISGFLYVPYAAIISHQMRLIPNLNPAIPSLQLAISAASVLAFVIPSLFLATITFRDYGPDLTLLLSDLFWLTLDLPWVPFWIQGWTIAWASFADESPNPIFPKSMGLVNFIAPSFLLSSSGVHIQKTGLYAWDSGLVWIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGG7</accession>
    <name>A0A2I2GGG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_349618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707280.1">
        <property type="nucleotide sequence ID" value="XM_024843751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGG7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGG7"/>
    <dbReference type="GeneID" id="36551451"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349618"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="157" mass="17988" checksum="3040743CF5C7E6B3" modified="2018-02-28" version="1">MSSISLFRIATRAVRPSGFIRTPQLPRSRVQAPIALAINRPSFSTTTQRRSGHEDETYEEFSARFEKEFDGVQDVFELQRNLNNCFAYDLVPSIEVLSAALKAARRVNDFPTAVRIFEGVKAKVETQEQYKQYLENLESLRLELGVALREELYPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGK4</accession>
    <name>A0A2I2GGK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707269.1">
        <property type="nucleotide sequence ID" value="XM_024852879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGK4"/>
    <dbReference type="GeneID" id="36560577"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471886"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="117" mass="12841" checksum="50078A32E7EDD370" modified="2018-02-28" version="1">MIILYSSSDVIDSFGRCSMDSRMVICPLLYDTGGSVLIIIISMAYYAVPRALEMHGPSPAHPYLPAPFIDTAETSLDKTLMLMGAKWSRLLGAPPSWMVRLRCDEMTGAESAHDWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH35</accession>
    <name>A0A2I2GH35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome P450 phenylacetate 2-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_402154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707492.1">
        <property type="nucleotide sequence ID" value="XM_024846405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH35"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH35"/>
    <dbReference type="GeneID" id="36554104"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402154"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="516" mass="58094" checksum="87E590572D6DFD29" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHD9</accession>
    <name>A0A2I2GHD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_472164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707559.1">
        <property type="nucleotide sequence ID" value="XM_024852917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHD9"/>
    <dbReference type="GeneID" id="36560615"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472164"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="190" mass="21740" checksum="C8274819C93A2EE7" modified="2018-02-28" version="1">MACNTRKKAIPHTLVPKLLSIPLFLNIDTKFTTESELSTEEMGIPMATDVTTSPREVHEKLEYKQPLEFDENDRTNVNQIFIRVVVSRGTIRPLNLMPLTAIIAELDGRMALGMYANAREEPTPDFVVKKITFDLQYLNMEPEMITAAHVFHVVRDILYEQARSGRTPNLTSLELTYEKPDGTWTFLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHL6</accession>
    <name>A0A2I2GHL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_434137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707672.1">
        <property type="nucleotide sequence ID" value="XM_024848652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHL6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHL6"/>
    <dbReference type="GeneID" id="36556351"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434137"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="262"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="457" mass="49304" checksum="331D8492407BD800" modified="2018-02-28" version="1">MFYSGSLQEGIAQAVSQAKAVVCFVRDDSETSSKWENDYFTDSEFAQLLESRSVLLRLTKDSAEAGFLTSFCPVTKFPTVIVIKDGTLREYIVPDVEKEGFQGRLRAAIGDAEAQPQAPAQSIAQSSSAASTGTTAPAPVSEPTTAPVPAPMSEPTPVSPTPASTAPRPQNIATQQQPQRKRDEVSAGKKPEKTEPSQSPSTKRQKPQKIDPAPAPQISIKRHDKPAQSSRTMKVEMPTSPPPKTEPEPAPKPQPTPPRQYRLQVRLFDGSSVRSSFTPSQTIRSDVRPWVDSQLEEKRPYNLKHILTPLPNRTLTIAEEEQTLEELGLGSTANLVMVPINTYTEAYSTSGASLPVRAVSSAYGIVSSVVGTATGLVGSLFGYVQPAPPSQAAPSTGSSQTENTNAASAARPRPTGSGGLNIRTLHDQRESRDDSQLYNGNQLNFQPRRDEDGRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GII2</accession>
    <name>A0A2I2GII2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystathionine beta-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_434416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707997.1">
        <property type="nucleotide sequence ID" value="XM_024848708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GII2"/>
    <dbReference type="GeneID" id="36556407"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434416"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19785" checksum="D904DBA6C991D28F" modified="2018-02-28" version="1">MASYMTASEAFAREKLSPNADKSTSQASWADKYRGATVEDLDPPLALSVSPNDPISSALMAAYERDYTHLTVISSTKRSLLGYLSIPRLRELLKEGAVKEPDSVSAAMQRFNRKRGTYQVITMETPLEELEQFFESEAGPNGEKREKQGFAVVTDASRKFVLGVATKADLEEFVKRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIS2</accession>
    <name>A0A2I2GIS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_434458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708039.1">
        <property type="nucleotide sequence ID" value="XM_024848720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIS2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIS2"/>
    <dbReference type="GeneID" id="36556419"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434458"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000375">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="3">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="4">
        <location>
            <begin position="330"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1230" mass="139532" checksum="5A6A578E684BAF72" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIV4</accession>
    <name>A0A2I2GIV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_444717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708116.1">
        <property type="nucleotide sequence ID" value="XM_024850651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIV4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIV4"/>
    <dbReference type="GeneID" id="36558350"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444717"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="241"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="472"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="512"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="680" mass="75043" checksum="AF62F280BC686809" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIY4</accession>
    <name>A0A2I2GIY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_472734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708143.1">
        <property type="nucleotide sequence ID" value="XM_024852976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIY4"/>
    <dbReference type="GeneID" id="36560674"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472734"/>
    <dbReference type="OrthoDB" id="5309803at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="114" mass="13003" checksum="508E3F3797AC8928" modified="2018-02-28" version="1">MAWYSILPPELIYVESWAARFFVILGIITIFPWAVLLLFDVSLYLWRTVGYEFPVVGGRARGMQRPRAPSLNERPDGQRRAFGLAGYEDISTATKLDAAERPVKRRTPTDRTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ28</accession>
    <name>A0A2I2GJ28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_462718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708183.1">
        <property type="nucleotide sequence ID" value="XM_024852115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ28"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ28"/>
    <dbReference type="GeneID" id="36559813"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462718"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57314" checksum="4052AA00C30BFC24" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJI3</accession>
    <name>A0A2I2GJI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708326.1">
        <property type="nucleotide sequence ID" value="XM_024848786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJI3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJI3"/>
    <dbReference type="GeneID" id="36556485"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434747"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39355" checksum="0B1C5848CD6A1CDC" modified="2018-02-28" version="1">MMVQPEQQQPHKEEKATGGVAAHLDYEMDQMSDFVAEMAQGMYALYITKINLADIDFARSVYPGTSVPPQFRKYVFQVLSSTRLPSSTILLGLYYLACRMRMLSSAKVFASGSGQVYRMLTVALLLGSKFLDDNTFQNKSWAEVSNIPVGELNSMELDWLFAFEWKIHDRIYDKQDGFASWRSHWETWRAKTVARAQETRHNLAPIDTNVSRGPRVSKPMLSPEGPIPPQYQRSSHFENSWLNPAASEYSPPSAPHSGPNTPDYYAVGPWAYSNPPPPYSRTWVPPQQYIPQAPRSQPPSYHHTPSYALPFAQSVWTGHGSSCGCLYCAKHIENYMCAGPFGAMQPILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJN4</accession>
    <name>A0A2I2GJN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Sec23/Sec24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_403838</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708369.1">
        <property type="nucleotide sequence ID" value="XM_024846497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJN4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJN4"/>
    <dbReference type="GeneID" id="36554196"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403838"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="17">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="18">
        <location>
            <begin position="388"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="20">
        <location>
            <begin position="636"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="19">
        <location>
            <begin position="732"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="16">
        <location>
            <begin position="859"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB53067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110540" checksum="90B4BE7817A63401" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL46</accession>
    <name>A0A2I2GL46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_451657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708905.1">
        <property type="nucleotide sequence ID" value="XM_024851208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL46"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL46"/>
    <dbReference type="GeneID" id="36558907"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451657"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="374" mass="41403" checksum="503CA902D4278C73" modified="2018-02-28" version="1" fragment="single">MNLHIQLSRDKPVYSNHDVVSGQLVLCSATPLQISGVVVTLSGTATTSLKDGRLNEHHELFRRSQRVFPPAAIAQLPGHPGLTIGAGTHRFPFSIPFSQVSECYKTERGETSEVTCASMRRPRSPAVHLLRRLPPSTGTIGTSGEIQYRLDAENCAITFQPLSDPLPRQPPSKQIQSVTLDPEVLGTTQPVSFHIETRLSHGPGLLRRHPIPLQVALTRISSTPCSVRLDDFQTMLVETTQARVQEGAEHLAQVWVVQTVANLGRSMVVERGNRPVWVSSDLWSSHSLPDRATSSFETCNLRRTHRLEVRLGFRFQTSPTLPSRLVVFDFRFPIYLMSASSTQLPATKEKMDLAAHEVTLQEDVAITKGAFVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL74</accession>
    <name>A0A2I2GL74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708937.1">
        <property type="nucleotide sequence ID" value="XM_024848041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL74"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL74"/>
    <dbReference type="GeneID" id="36555740"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431463"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="272" mass="29791" checksum="539D0AB8FF5F6C7F" modified="2018-02-28" version="1">MSYYVKTNLEAVFQRGQILAPLLETSRLRDEAFGKFWLQFSSLREDSIQSAQPAADQPTPPTQGEIQGSSDLIPPILAQASGLVLDVGPGTGTQMPLLRSPAIKAIYGAEPCHGLHEELRARANANGLGEKYHILPCSVAGSQLNPVLQKNGLDRTDRGVFDTIVCVRVLCSVPDMQQTVNELYALLRPGGRLLIVEHVVNPWRTAKGSVVARALQTLYGALGWSFYVGDCCLNRDTEKALRTAGEWESVDIDRWFGRTVMPYISGVLVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLE7</accession>
    <name>A0A2I2GLE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709008.1">
        <property type="nucleotide sequence ID" value="XM_024850430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLE7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLE7"/>
    <dbReference type="GeneID" id="36558129"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441984"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="779" mass="87939" checksum="C531A821052D374A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLW8</accession>
    <name>A0A2I2GLW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_346374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709151.1">
        <property type="nucleotide sequence ID" value="XM_024843565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLW8"/>
    <dbReference type="GeneID" id="36551265"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346374"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="64" mass="7681" checksum="B7B4E0BBC7D541E5" modified="2018-02-28" version="1" fragment="single">VRFYNLLSELLLYIIRYIKKDNSLLLLSSVNRTLHHLYTCHIFRKLKMAFLTTGLDYLLQISYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM67</accession>
    <name>A0A2I2GM67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_504818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709251.1">
        <property type="nucleotide sequence ID" value="XM_024854236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM67"/>
    <dbReference type="GeneID" id="36561942"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504818"/>
    <dbReference type="OrthoDB" id="4463410at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="349" mass="39400" checksum="0658F463BF17836D" modified="2018-02-28" version="1">MAKLWEVTQFNVRTSARDSTSDSLFANGQMQVKVIVSIKAFLLDPDENGNSDYQLTKAELEGIKLINYYSRNELTGRWTYSTTENGFAHVLPRAGAPVDPIADGTQTIGFWVSSTQITNENIAAQISQPGKDKPTTVTTTGGIFDSMVTLEAIQPVTYTTDNVSFTREDTAEGTWRIQTGSNSSTYRWDQDNYYVSSHDYPFLKVDRHQVDTTGNDNGVVRSSDMQDSFAYLKAGKNDISIFYMFDVGKEMTVRRGLYTWSGSTTYYRYAQIKVNQRVNALCLTRLLFFSGYTSWWNNWDANAWFTIYDLYGNHGHFSVRTEGQNTLSFTSRNVRSPAEGTSVGRTVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM85</accession>
    <name>A0A2I2GM85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_482221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709289.1">
        <property type="nucleotide sequence ID" value="XM_024853877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM85"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM85"/>
    <dbReference type="GeneID" id="36561575"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_482221"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="470"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="576" mass="62245" checksum="F956D778C5C14DEB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMF5</accession>
    <name>A0A2I2GMF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_504880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709359.1">
        <property type="nucleotide sequence ID" value="XM_024854246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMF5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMF5"/>
    <dbReference type="GeneID" id="36561952"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504880"/>
    <dbReference type="OrthoDB" id="5414787at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="762" mass="84187" checksum="4AD5B5127B2D2708" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMU2</accession>
    <name>A0A2I2GMU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_442309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709472.1">
        <property type="nucleotide sequence ID" value="XM_024850455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMU2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMU2"/>
    <dbReference type="GeneID" id="36558154"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442309"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="377" mass="41676" checksum="1FF4625BF20753C4" modified="2018-02-28" version="1">MASSSPSDDVSRASMVTIPTIVTTVLALILTLLRLYVRRYMIQLLGWDDLFNVLAMVLALIVMGLVLAATHYGLGRHVEFVDPAQSAYSVKMLRVAEFLLIFSTIFIKISISLFLKRLFLTSKKWKIFFWCFIAFNTITSILDAAVIFPQCTPVEFNWDKSIEGGSCWSNEAIDAVGIAQGAIAAVTDFVLSILPILFLWNVKLPKRVKVGICGIMALGFASGAFAIARTALVPDLTTTTDPTWDLVELFMWADLEATFGVIAAAAPSVRPLIGHNAMTTESYTRSKSHTLPLRSLATGHQSRREWRQTILDTMDEPGGRISNDGDSQSNLWHNDQGIVKTMSIEVVTTQRPPDSELQLQLYRGAGERSSNERVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMY3</accession>
    <name>A0A2I2GMY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_397418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709537.1">
        <property type="nucleotide sequence ID" value="XM_024846174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMY3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMY3"/>
    <dbReference type="GeneID" id="36553873"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397418"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="170"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="426" mass="46643" checksum="4B98477C0B0B01A6" modified="2018-02-28" version="1">MGSTATFPRIKEVRTFLIDGVGSGGDYHNVKGGHWLVDSDISTPMTRWAQYRGSRTSWGINVLGSFCVEVEATDGTKGFATGFGGPPACWLVQQHFERFLIGADPRDVNELFEKMYRASMFYGRKGLPVAVISVIDLALWDLVGKVRNEPVYKLIGGATRSRLNFYCTGPQPASAKAMGFSGAKVALPHGPDEGTEGLLKNLAYLRKQRESVGPEFPLRVDCYMSLNVPYTIELVKRAEAEGINIDWWEECLTPDDFDGHALLKRAHPTVKFTTGEHEYSRFGFRKLVEGRNLDILQPDVMWVGGLTELLKVSALAAAYDLPVVPHASGPYSYHYVVSQPNTPFQEYLANSADGHTVEPVFGNLFLNEPIPTQGYLDVSVLDKPGFGLELNPAAPLIPAASILTPAPQRSLAAPTDQEQGANGNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN91</accession>
    <name>A0A2I2GN91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_460512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709647.1">
        <property type="nucleotide sequence ID" value="XM_024851945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN91"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN91"/>
    <dbReference type="GeneID" id="36559643"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460512"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="127" mass="14272" checksum="C2ADB85DA9F4BD36" modified="2018-02-28" version="1">MSGQDPGKKRFEPKVPVQLDPPKDDPISVEELSKCDGTDPNRPTLVAIKGIVFDVTRNAAYSPTGQYHVFAGKDPSRALACSSLKPETCVPDWYDLEDKEKTVLEEWFTFFSKRYNIVGKVQDATNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN95</accession>
    <name>A0A2I2GN95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_452112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709631.1">
        <property type="nucleotide sequence ID" value="XM_024851246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN95"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN95"/>
    <dbReference type="GeneID" id="36558945"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452112"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="199"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="531"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="751" mass="83012" checksum="C1573F8121AFB211" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP14</accession>
    <name>A0A2I2GP14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_470073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709918.1">
        <property type="nucleotide sequence ID" value="XM_024852705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP14"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP14"/>
    <dbReference type="GeneID" id="36560403"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470073"/>
    <dbReference type="OrthoDB" id="4179303at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="490" mass="55953" checksum="1BA2ED721C8389F6" modified="2018-02-28" version="1">MDTPRRIDDLADELISDILSYLLGSESVAYHPHDPSRGPNGSSRTAYGEKTELDRFRLVCRRFMRIGTPRKFPRFVLRFSRDGFQRLEDLLHMQLACHVRYFTYMVRPFYQGSGWSHALTTVESENRPVAHIHRRRLHDQKSIVDRNHDLALLRRAIAAFPALQQVKLLRLQDEADEELLGYLRDYSLEEDARLDWESACTRAVTSLGISLLDSKCTSVRFVAPQISPEATVRLLQAPPTMLSALGARLTSLDVTFHARADMTTSMETLSHVFYEFFLAAKNLTAIHLGFPANLPLDLSLERIFHRLQWKRLRTLSIQGWRLGSDEIIALVRRHRRPLRDLSLASVYLRAGGRWCDVLSVLHDEMDLLERIDLREINYAAQFDADHHSHHYSPLNGNGNGNGTGTGDGAFDGPMLSVVAQPSPDLPSPDYLSFAPRGNTRRSFTDATLEKLRVLTADDLGDNGASVHRRQRLFWEAWVLSSSRNNIRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP26</accession>
    <name>A0A2I2GP26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_432259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709931.1">
        <property type="nucleotide sequence ID" value="XM_024848224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP26"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP26"/>
    <dbReference type="GeneID" id="36555923"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432259"/>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11156" checksum="1ECC568825477D2F" modified="2018-02-28" version="1">MSNQQNQPPQSQQQPRVILDPHNYQRPRPAPRPRTVQDIRQTKEYKVAARRWLSTIVALPILMYTSYMLFERTYGNKSPRSLGSPSSSGQEGKKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPM2</accession>
    <name>A0A2I2GPM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1682 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_432403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710127.1">
        <property type="nucleotide sequence ID" value="XM_024848255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPM2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPM2"/>
    <dbReference type="GeneID" id="36555954"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432403"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="361"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="437" mass="49588" checksum="A60CE33F88F24669" modified="2018-02-28" version="1">MANLLKNVFGGSQPSGAAKVEDDFADFVSAPNPSPASIVASSASPVPAFNTQGVGAGVPYTKWYRVWERTSPKDFIQEAMVAPIILLIVVFHLWGTRKNRRKARDWAQAHASALHSEFAVVGFNGAQKSEDVASELISPDSLLKEKTPQEFTSYATGRQNVAFVDIAVKLPKRYNPVTYWMDLVFGFLFDSWQAPTETFEAVAYTFDGKEKDVVPVPAQDTSSLKVNNSTYDSFIWAVVHKNHMRQFRNDRYDASMTFTRDNAKLPQWVTVMTESAEITDALLTPELIQAIEKAGEDFKYLIVTDQPTDKPLKIEETTPRKRIQVCTSLPSSASGYASTLPLFTQFLRFADKLVASAHFRAEVLRKVRNAREEEIKKLRRVDEEEKAEERKLAAEKIKKEERERLLRGMSADEQRKFLDREREKGQRRSMKRYTKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPT3</accession>
    <name>A0A2I2GPT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_398667</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710187.1">
        <property type="nucleotide sequence ID" value="XM_024846238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPT3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPT3"/>
    <dbReference type="GeneID" id="36553937"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398667"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="102"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB54885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="475" mass="51749" checksum="B70F5A62CB230391" modified="2018-02-28" version="1">MPPRSVSTREIARHNGADDCWLVVNNQVWDLSDFAPNHPGGAETILRYAGRDATAAYNEVHGPATIKILPATQLIGQLDLSSVDETWTSKSTIQAPSGDTRPPLDAIFSAHDFEDAARSSLSKKAWAFYSSAATDLISHAANQSFYRRIWMRPRLLQNVLSVNTQTTVLGAPFALPVIAAPVALARLAHPTGEKGIASAAASKSIGYCIPITASFPAEEITATAPDHPYFFQLYVNRDRVASEAILHRIWGLGVRVLFVTIDTPVPGKREADERVRSDEAISMPMTGTRASQDHKGGGITRTTGSFIDETLCWDDLAWVRAHWRGRLVLKGVQSVEDALMAVEARVDGIVLSNHGGRNLDTAPPALLTLLELGRHCPHVLRETEVFVDGGIRRGTDILKAICLGARAVLIGRPVMYALSYGKEGVEHLIDIFGSELQAAMKLVGITDLSQAHRGMLNTQDLDHLVVRDLTRRAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQQ6</accession>
    <name>A0A2I2GQQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_35796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710519.1">
        <property type="nucleotide sequence ID" value="XM_024844253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQQ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQQ6"/>
    <dbReference type="GeneID" id="36551953"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_35796"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1170:FF:000001">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="10">
        <location>
            <begin position="360"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="723" mass="77848" checksum="FC84C7F27946491A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRP4</accession>
    <name>A0A2I2GRP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_43302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710836.1">
        <property type="nucleotide sequence ID" value="XM_024848389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRP4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRP4"/>
    <dbReference type="GeneID" id="36556088"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_43302"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="700" mass="78273" checksum="83181FAA1C3A1857" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS03</accession>
    <name>A0A2I2GS03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Acylphosphatase</fullName>
            <ecNumber evidence="1 2">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_46373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1 2"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710956.1">
        <property type="nucleotide sequence ID" value="XM_024852186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS03"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS03"/>
    <dbReference type="GeneID" id="36559884"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_46373"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="4">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="128" mass="14379" checksum="41B44DFAC50A2447" modified="2018-02-28" version="1">MSIYFICIFKLTSSICYRRHILVEVNMAQKRIAFKVHGTVQGVGFRDFTQKRATEFDLKGWVKNTICGRVEGEAQGPDSAIQNLVKEINNGPRLAHVVKVEKKEIATQEGESQFGVKRTSESAFDATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSL8</accession>
    <name>A0A2I2GSL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_433347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711173.1">
        <property type="nucleotide sequence ID" value="XM_024848468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSL8"/>
    <dbReference type="GeneID" id="36556167"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433347"/>
    <dbReference type="OrthoDB" id="4490227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014169752" description="DUF7136 domain-containing protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="3">
        <location>
            <begin position="39"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="288" mass="31107" checksum="3DF5233B49EA3992" modified="2018-02-28" version="1">MKPSKPTSSTRRSSAFWTTISPLVLLSNAIIQPAKAISYPTTIEIDLLFPLPNKTYPNITSFPVIFALQNVPAANEFGYTISWNLRSEENSTVALGSIYKMTYRNNTDLPFLLDDGNIAILPDTAYNGTRLESGRYSLAWKYSMVTCTQIGDRTQYNIGKTQAGNTHFFDVEEKGRAETSGFKLGLDAECPVFADSIVVRDATKGGCPFMKGSSDADEKDRDPCRAKLNAKQANCVQGNVTGNYNASLCREAFGDGDASESGAGRMVANGLGMFGIGVVGFIGVLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSR8</accession>
    <name>A0A2I2GSR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_443612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711225.1">
        <property type="nucleotide sequence ID" value="XM_024850566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSR8"/>
    <dbReference type="GeneID" id="36558265"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443612"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014132372" description="Integral membrane protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47078" checksum="92E2A7CEA001BFB3" modified="2018-02-28" version="1">MLLTFALVYCFLILFTRWHTFRDPTSAFFDSSTGYLPAYSTVRFQQADRYINDANNGAAYTQWKASESPRMCVGVASVARKGARYFRSAVGSILEGLSEAERANMYLILFIAHTNATEHPAYSEPWLHNVADRVLLYNETEVDVNHIHDLETDSAKFFAREKALFDYTYLLKACQDVNASFVSMVEDDVLALDGWFHRTLYAVDEADQMTVDKGASSWLYLRLFYTEQLLGWNSEEWPAYLFGSVITVGFIACALLGIRRYQPKIRPMLPDDTILLLCFICTPLLIGLYFAAGRVTMRPIPPGVHEMSRFGCCSQGFVFPQSRVPDLIHLYEERKAGYVDMLTEDFANANDEIRYAITPSVLQHVGRKSSKEADWNNTKPKQGITDLWNFAYEMNDPAYLRQEHDAFRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQA9</accession>
    <name>A0A2I2FQA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_371557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000028">
        <property type="protein sequence ID" value="PLB42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371557"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="86" mass="9616" checksum="CBDE0A0FC01077AD" modified="2018-02-28" version="1">MVRLVFRPYTKFDDRFARQNRCEPPPEFPLASPYSGIVHHLSGPHIYALTQIHPKTSGSVDGAPREGAPTSVRFHCAHGFDTRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQF8</accession>
    <name>A0A2I2FQF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_491103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000024">
        <property type="protein sequence ID" value="PLB42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_491103"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="11770" checksum="D10D649BC56B1C05" modified="2018-02-28" version="1" fragment="single">IPKFDDRFARQNRCEPPPEFPLASPYSGIVHHLSGPHIYALTQIHPKTSGSVDGAPREGLPPPFAFTARTGLTPEHSPSVPKRVPRSRLAALHPGYKVPRRALHSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSD1</accession>
    <name>A0A2I2FSD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WGR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_513900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698850.1">
        <property type="nucleotide sequence ID" value="XM_024855158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSD1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSD1"/>
    <dbReference type="GeneID" id="36562864"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513900"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WGR" evidence="2">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="294" mass="32884" checksum="BDFC5A8D09FC8AD8" modified="2018-02-28" version="1">MKEPFKKVHLCSFGHFGGNGDKIPQWEAFKRNVEAVRKAKRLKAKIVSYDWLEDSLMSKSRAPKREGPYLLETILKNEQKRADAKAKAQKASKQQAKTKAKQTVKSKDPFAAGSRAVKKGTATTDYHIYTDKGVTYTATLTRPTIQATREKYQLKIYELASDPITYATHVKYTRTGKSKIELIAPIGSTLSVAMSAFKQFFEEQTGKRWEDRLNGLAPERKRDSDGNTLPISDGWFYHEQNTSIISNYLREGPRADEASTVTASDDSTDDGTAGGDEDAESQSIGEMMAIHDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT13</accession>
    <name>A0A2I2FT13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_369160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699058.1">
        <property type="nucleotide sequence ID" value="XM_024844895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT13"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT13"/>
    <dbReference type="GeneID" id="36552595"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369160"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="375"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="475" mass="52702" checksum="BC14A78265ACEACB" modified="2018-02-28" version="1">MLYGEGNINFPPALLGILAAGASCALPTYQTAVGLPFYLEKLGVYTVLCAPEVEAEVQAAARKVGIPQDRVFVVDESFEGTGGSSTLGSCHWSSLLESPGSDHYQRPRLSPEEAKETVAVFFQTSGTTGSPKLVGRTHYELVGNVEQMLFWYHLQPRGKEVFFCTFKFCGIVYFMMGLMAPLKARYQTVFSPKHQMPTFLAALDRFKPTWAVLPKYAIHEILDYPGPVDCSSIHTLTTGACHIPFSLSEEWQTKHRSPLFNAHGMSEGGCFFLRQSYSFATDDSIGALLPNMEGIVVNEKGQPLARNQTGEIWARCPFFMRGYYQDAQETAKCLTPDGWLKTGDIGWVNDQDQWYISGRLKDQYLIGGLHVSGNEMEVAMRQHPDIVDVSVIPVKLPHERDNVPRAYLVQTPGANLTVDELLGWMNKECSPAVYPRGGAVFIEKIPISTAGNCKVDQKALIERAKQELLSEPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT99</accession>
    <name>A0A2I2FT99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Formin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_393921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699180.1">
        <property type="nucleotide sequence ID" value="XM_024846036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT99"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT99"/>
    <dbReference type="GeneID" id="36553735"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393921"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000027">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000032">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000033">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000034">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000078">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="373"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="94100" checksum="BD49BD2211517BA5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTG9</accession>
    <name>A0A2I2FTG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear localization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_64970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699218.1">
        <property type="nucleotide sequence ID" value="XM_024855318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTG9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTG9"/>
    <dbReference type="GeneID" id="36563024"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_64970"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="680"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="728" mass="78106" checksum="644559E5A82EF19D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTH5</accession>
    <name>A0A2I2FTH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase inhibitor I78 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_441389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699250.1">
        <property type="nucleotide sequence ID" value="XM_024850297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTH5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTH5"/>
    <dbReference type="GeneID" id="36557996"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441389"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9321" checksum="15C9DC0A6BED1478" modified="2018-02-28" version="1">MPLVVPGMTNASANDADNKQEWLTKLAGKKISESTSDVNTFAKKDLPSSHRVLKPNDAMTMDYRPDRLNVYVGEDDIVHDVNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTL8</accession>
    <name>A0A2I2FTL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_66920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699287.1">
        <property type="nucleotide sequence ID" value="XM_024855330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTL8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTL8"/>
    <dbReference type="GeneID" id="36563036"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_66920"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="183"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="943"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="967" mass="104073" checksum="84FC7A2DFEE60E39" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU93</accession>
    <name>A0A2I2FU93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_513439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699520.1">
        <property type="nucleotide sequence ID" value="XM_024855110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU93"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU93"/>
    <dbReference type="GeneID" id="36562816"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513439"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="138" mass="15346" checksum="3759CA94F3D5DE7B" modified="2018-02-28" version="1">MPRGSCFCGEIRYEFSEESAQKVICHCLSCRKITGSTYTTNFAIPESNLSILSGSLRDCTRRHECGMNLTVFFCGGCGSAIYKTATQKIFHGKIILLVGTVDEEQGIEKAAPAREFYVKYRGDWVQPVDGAVQDQEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUH0</accession>
    <name>A0A2I2FUH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_468009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699597.1">
        <property type="nucleotide sequence ID" value="XM_024852519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUH0"/>
    <dbReference type="GeneID" id="36560217"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468009"/>
    <dbReference type="OrthoDB" id="4505290at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014125570" evidence="1">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="110" mass="11669" checksum="3A7DFC6C2A419BBC" modified="2018-02-28" version="1">MHFLSTLMTVLGLSAIVLAAPAPAEANTQDPGWHGCGNGSACHADADCRSRPECIQMAGGPSHIDRIHCGQANHPVACWTELCPLTTSHNLFKITIISIYNAHTLLEPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUI7</accession>
    <name>A0A2I2FUI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_440614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699611.1">
        <property type="nucleotide sequence ID" value="XM_024850121.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FUI7"/>
    <dbReference type="GeneID" id="36557820"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440614"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000125">
        <property type="entry name" value="Kinesin class 4 (Chromokinesin group)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="50"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="857"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1562"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1645"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1572"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1588"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1607"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1737" mass="192643" checksum="4C4FE292E11F287B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUP0</accession>
    <name>A0A2I2FUP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_440628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699623.1">
        <property type="nucleotide sequence ID" value="XM_024850126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUP0"/>
    <dbReference type="GeneID" id="36557825"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440628"/>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="805" mass="88848" checksum="89019A1AE94656B8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV00</accession>
    <name>A0A2I2FV00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase DBP10</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent RNA helicase dbp10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_440752</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699780.1">
        <property type="nucleotide sequence ID" value="XM_024850153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV00"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV00"/>
    <dbReference type="GeneID" id="36557852"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440752"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="122"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="362"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="639"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="860"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="868"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="919"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB44478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="937" mass="103284" checksum="EDDD6F78F19C9975" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV33</accession>
    <name>A0A2I2FV33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_417125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699784.1">
        <property type="nucleotide sequence ID" value="XM_024847160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV33"/>
    <dbReference type="GeneID" id="36554859"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_417125"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="677" mass="75222" checksum="DFE6D0246EF0FEB3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV69</accession>
    <name>A0A2I2FV69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_440805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699841.1">
        <property type="nucleotide sequence ID" value="XM_024850167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV69"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV69"/>
    <dbReference type="GeneID" id="36557866"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440805"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="111"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="256" mass="29033" checksum="36887080AC03EC15" modified="2018-02-28" version="1">MADANKGAKITLYWLEKSRSQRILWLLEELGVSYELKTFKRGADMLAPPELKKIHPLGKSPVITIETEHSDKPLLLAESGAISEYLCDHFGNGNLVPQRYQDGKEGQVGAESEEWMRYRYFMHYAEGSLMPFLVFKLVMDTVKNAPGMPFFIKPIPRLVASKVEELFVYPNVFANFNFLEERLKTAPDGGPFLCGKQLTAADIMMSFPVIAASGRVPLKDQYPKLQEYVDRLQQEEGYKKAVEKVIEVEGKFDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVE6</accession>
    <name>A0A2I2FVE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_459108</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699907.1">
        <property type="nucleotide sequence ID" value="XM_024851842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVE6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVE6"/>
    <dbReference type="GeneID" id="36559540"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459108"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000845">
        <property type="entry name" value="C2H2 type conidiation transcription factor BrlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF159">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0183">Conidiation</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0749">Sporulation</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB44605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="444" mass="49631" checksum="2ED220CB10D85DCB" modified="2018-02-28" version="1">MDSALEAPPRKDRDTTETNEDMRSQSTIDRLTVEVDCSSLGSNECPSMSNSFSPLDSPTPTPTSIYSQGALASPGWQESGSYPGHTYDRNPGPAPMRSAFRLPGMPSNESMGMSYGSMETQERMPMPDFLSGYDENVEQFWIPSDAPKPYEPGTHGLPYPPVMHQYPPMARSGYRHQNPPYLPESTTNPCLSRSIFHQPERVPTSMSMNNMIPWMAPPTESIPQTIAPSQVGPVTPPPSYSDYSTSINTLKSHTPTTPIRSGSLGTISGTDTPMSRLSGHGDYLDEFQQSPVYHDGLQRPHRTLSRKVARKQSSKQSLSLENLPSIIKQVQFKCKEPGCKGRFKRQEHLKRHMKSHSKEKPHVCWVPGCHRAFSRSDNLNAHYTKTHSKRGGRNRYVATLDETSPDYDPDFRGQLTPDGRPIYGSKLEEPMIDARELSVDAWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVZ8</accession>
    <name>A0A2I2FVZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dockerin type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_366130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700097.1">
        <property type="nucleotide sequence ID" value="XM_024844745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVZ8"/>
    <dbReference type="GeneID" id="36552445"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366130"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15892">
        <property type="entry name" value="BNR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49385" checksum="E44EB308142FDE2D" modified="2018-02-28" version="1">MTSPIIHILGDDPHTTHRLNACAYQQSAITTFNGWQYVAFYTSSPTAARRVTLARRALQTQSWQYLTFNDYEQTTDDGHNTISIGICPGDATIHLSFDHHCDVLKYRISRLGLAADTDESSWVGDNFSPIQNHLPGQGPSPLKDVTYPRFLPAGRDLYFECRIGKAGAGSDILHRYTPATAQFTSLGTYLVGHRCNPYPNGISFHPETAALHVTWTNRHFIDYDGADDQDSTAHKAQAGPNGPENNEGLYHSYSTDGGATWLNSAGGLVASLSPETTTGLDSQDARLRVKIIPRDSGIMNQEAQYIDSHGGVHVLNRENTSGREMWVHYYRDPGVGGWSFYAVPGVFPTATGPRGKVVYCGRSNVVYLVLPGNTQDGLIIARMSGLQSLDREFEVVWRRRGYVGEPLVDEEAFLHFGILSVFTMLEKDPAERRIAVLQFDVDELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW09</accession>
    <name>A0A2I2FW09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_415585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700124.1">
        <property type="nucleotide sequence ID" value="XM_024847067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW09"/>
    <dbReference type="GeneID" id="36554766"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415585"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="726" mass="81162" checksum="5AD93A52AAD89AD5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW21</accession>
    <name>A0A2I2FW21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_429569</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700133.1">
        <property type="nucleotide sequence ID" value="XM_024847898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW21"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW21"/>
    <dbReference type="GeneID" id="36555597"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429569"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="18" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014142002" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="25"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="210"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB44831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="599" mass="65477" checksum="E3BB2D40728B598A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW64</accession>
    <name>A0A2I2FW64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_415682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700182.1">
        <property type="nucleotide sequence ID" value="XM_024847074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW64"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW64"/>
    <dbReference type="GeneID" id="36554773"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415682"/>
    <dbReference type="OrthoDB" id="2099887at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF1">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014199122" description="Regulatory P domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="48987" checksum="096FC420865160D4" modified="2018-02-28" version="1">MKLSIISSLALACAVTASREGESRMAHLMELKMEHRERARSQGLFKVNKYIDLGSAKCVDGKAGEYSCENVDLQGFLSHQALGSKTREGNDVWGWESADGREFGVVGQTDGVAFVEILDDGSVEYVGRLPTQTVSSVWRDMKVIKDHVYIGSEAEGHGLQIFDLTKLLDTNSSNPTSFSIEDDLTAWYDGFGSSHNIVAHEEKDVIYAVGTARRLECAGGLWIVDVSDPANPVSPGCANEDGYVHDAQCVVYSGPDTKYTGQEICFNYNEDTLTIVDVTDKKNPIQISKTPYVGASYTHQGWIATPDQAYLLLDDELDEVDGTGEAANGHTTTYIFDVSDLSDPKHTGTYQSPVRSIDHNQYVLDGLSYQSNYGSGLRIVDVSSISDDPSGKGLKQVGFFDVHPEDDEVGGEVEFVGSWSVYPYFKSGYILLNSIERGIYSLKYTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWV5</accession>
    <name>A0A2I2FWV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF605-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_391700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700421.1">
        <property type="nucleotide sequence ID" value="XM_024845948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWV5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWV5"/>
    <dbReference type="GeneID" id="36553647"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_391700"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB45119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="404" mass="43313" checksum="CCE0EBBBE7126CF2" modified="2018-02-28" version="1">MASNIPAGLKSADIGRFAVRAAQLERVKPVIAYWCNFWIVNQIIEKGLHSDDEVKLYTTNLVDKLETFKEENPDNDTVTDAVAANAYVEEFGLEIFARAEATMRANKVTKQTADTFQAAATFLELCQIWHTPEPELAVKIKFAKYHALRIAKAIKAGEDPNETNPVIEEDNLEPKEDDPEVQAIVQSLPPADPEALPGRQPSVEDVPDEPSAQPSGSTPTLPQVPTSFADIQPPHQNAPSPAMDLDHDQGAPLNLPSAPDTFASSASAPNLPDTPTQIGRHHSSGDPNAFQSFPPPSSSPDRSPAGTPFDAKAFYNQSGPPSLPAQTSPGPLPVVSRPTPHSVPSTAHIPVAPTPSQANTPAVDDNAIAQAQKHARWAVSALTFDDVNTAIKELKNSLKQLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX04</accession>
    <name>A0A2I2FX04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenoprotein domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_440231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700398.1">
        <property type="nucleotide sequence ID" value="XM_024850031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX04"/>
    <dbReference type="GeneID" id="36557730"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440231"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19207" checksum="CBD2CE18085B98FA" modified="2018-02-28" version="1">MSEQQPPPTTTAATPPPSASAVATGAAEASRPAKPRVAIQYCTQCKWMLRAAYFAQELLSTFSTDLQEVSLIPTTGGIFTVTIYHSAGPATSTSTSAQEAQIATQLWDRKTDGGFPEVKVLKSRVRNVVDPGRSLGHTDRALKGQGQAQVQGQGNGAPSDAQGQSQTQPQTQSSGQECEDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY45</accession>
    <name>A0A2I2FY45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_365558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700857.1">
        <property type="nucleotide sequence ID" value="XM_024844712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY45"/>
    <dbReference type="STRING" id="1392250.A0A2I2FY45"/>
    <dbReference type="GeneID" id="36552412"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365558"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014146218" description="Cytochrome b5 heme-binding domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="266"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="359" mass="38318" checksum="16E4EEF2CD37D41F" modified="2018-02-28" version="1">MGWVGVVTLIATACFVLYKYPPASWTPDSPPPQPRSTSDEPKPPVISDETKQPESQPVEAEDTSAEESQSTPKASASSTPSLEVPTFSLDADRSSSIAQPSPDENLPLPPQEERPQNGSAKPVAIPTAPSPEDSLMPPPTGPLPRRQPNASSSSLMPPPPPPRLRPNMSQNQQQPPSQPSLTAGRVPPRPTTGSNSLRPPPSAASSMRGPLPNRSPNSLAPAKLTAKPSTPAKRAVLEPGYSPLDWAALTSNPKNNLRGANLPPHLIRVTPSQLKAQNGRKGTDAWTSYQGKVYNITPYLPFHPGGRGELLRGAGKDSAKLFFEIHPWVNWDAILGECLVGILVSENDEGSENKLDAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYE8</accession>
    <name>A0A2I2FYE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_248673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700962.1">
        <property type="nucleotide sequence ID" value="XM_024843011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYE8"/>
    <dbReference type="GeneID" id="36550710"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_248673"/>
    <dbReference type="OrthoDB" id="4227165at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="273" mass="31016" checksum="AA2ECFB0C0E59B93" modified="2018-02-28" version="1">MPSPQPKRIVLEKSRTVRRRYQRSNKRLEFSASQIARIERDEEREKRAKKLREREKKRIANKKKKAEKEAKEREERRRQGLPPGVDQHALPVPSSQPLLSRFLRRKDAEVEKEVPEQTELVGEEDAEGDLEGELELGSLGSLEEESFLSDLDELSDDTIIAGLENGLLQEGQGQGSTKASRGVGAAAPREKDDDEFSDCSIFYDEDIIKEADSIITARDSKEPQPEKSDTRAPIGLPVGDSFQDDTADLLEEFGYEFDTDEEFERELVQLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYK4</accession>
    <name>A0A2I2FYK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_414180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701009.1">
        <property type="nucleotide sequence ID" value="XM_024847008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYK4"/>
    <dbReference type="GeneID" id="36554707"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414180"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="448" mass="49093" checksum="DC79718C7AC82577" modified="2018-02-28" version="1" fragment="single">MSSMPDKRKPTGSVSGSSPYAKRSRSSYADEGEGDMPPAVTPYERPRNHPVYGQKSAFPGLDTAGDDELFYGPAEDGMEYLRMVRSEANSLPFLFTAPQAEESTVEPTVTNDETEEPKENAEVVEKKETVVEGVYADGVYAASAAITTGATGRSDIAQTTYSDAQATYYNLLHHRFLLLRSILKCSPPSTAIAALDDSHPISLPRHSKTACKEWRRLLLAVDPQTVQLACMDMDSVLGVLGIMARLMSENVRSGDAERIRRIGAWAWGLLSKCRDVGQLGTEEVGEIRELGKRAVKILRKMKEEDEKNNQSLAEGGDASDKESDEDEQADDQGHAEGPENQPNAASDPAEAPDQDMLDAEKEPSTDKLEQAKARLQAKIQSDENEPQTNEPEAPEPEPSAEDLAVEASMQTRAMLDMIITVIGEYYGQRDLLEARELWTGPPEEDLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYP1</accession>
    <name>A0A2I2FYP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">P170DRAFT_389888</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701056.1">
        <property type="nucleotide sequence ID" value="XM_024845886.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FYP1"/>
    <dbReference type="GeneID" id="36553585"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_389888"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000560">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10 25" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="24">
        <location>
            <begin position="286"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="83"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="456"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1326"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1371"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="456"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1326"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="1342"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PLB45754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1392" mass="155611" checksum="502A6235CB9645C9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYS2</accession>
    <name>A0A2I2FYS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_512412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701084.1">
        <property type="nucleotide sequence ID" value="XM_024854987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYS2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYS2"/>
    <dbReference type="GeneID" id="36562693"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512412"/>
    <dbReference type="OrthoDB" id="5389296at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="465" mass="51011" checksum="461AFE01905E7263" modified="2018-02-28" version="1">MRQFFYNTRQRMPRTPQFASTPRFLLSQRGPPPSSSLSARRPRPEAIDEDDSPQNTPLAKRVRGRPFVATPASRLTDTPRTATTRDVIQDSEDDESALSQADVDSDMEAEYEALFGEREGSTAKRRRVGDEDHDGDQQNGDHNGIDDEDDNDNKNGEADDQDYHQPPNDTGNETPQQEHTHSHTHAFSSDENIPSSPLKSPSKTQLPTPTPNANRPRFLLSASSQLHTPSQSHSHRYPPSSTKQTYTTPSQFMTPAAARIATDSEPGPAAPPSSIPPPSTRRKPGFVLPRSPSPDAAVDDVLSLFSPSRTQRRGKGSRASGQGYVSGGMAEQVRGWVLEMGVKGNHVSEHGPGQKYAFIVRVEEAERSVMGSCGELVFVRGVHVDEGLDGGDDGVVRNVLLMGAPQSRSLPALEEGEETEIPDLKTGDRVGVGRGLVWDVELESMQESRSGEMEKWQVCMEWDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYX2</accession>
    <name>A0A2I2FYX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_363947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701131.1">
        <property type="nucleotide sequence ID" value="XM_024844617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYX2"/>
    <dbReference type="GeneID" id="36552317"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363947"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="540" mass="59447" checksum="145D88224D919E98" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZI1</accession>
    <name>A0A2I2FZI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_364928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701342.1">
        <property type="nucleotide sequence ID" value="XM_024844672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZI1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZI1"/>
    <dbReference type="GeneID" id="36552372"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364928"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="147"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="523" mass="58857" checksum="24D2B974076FE223" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G015</accession>
    <name>A0A2I2G015_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Lysophospholipase</fullName>
            <ecNumber evidence="3 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_501180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 10"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701529.1">
        <property type="nucleotide sequence ID" value="XM_024854161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G015"/>
    <dbReference type="STRING" id="1392250.A0A2I2G015"/>
    <dbReference type="GeneID" id="36561867"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_501180"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF62">
        <property type="entry name" value="LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="42"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="633" mass="68876" checksum="8E6CFB7F5FF1BACE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G099</accession>
    <name>A0A2I2G099_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_415261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701602.1">
        <property type="nucleotide sequence ID" value="XM_024847056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G099"/>
    <dbReference type="GeneID" id="36554755"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415261"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF31">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="560" mass="62144" checksum="842528ED59FF8519" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0H7</accession>
    <name>A0A2I2G0H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_411542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701638.1">
        <property type="nucleotide sequence ID" value="XM_024846898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0H7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0H7"/>
    <dbReference type="GeneID" id="36554597"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411542"/>
    <dbReference type="OrthoDB" id="3029470at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="443" mass="50076" checksum="25066E5E3F5688BC" modified="2018-02-28" version="1">MTSTAVQDQVDDVESFFDPAVCAALYNRIIHIGFEGSQCGQRGDRLAKNWFHAWRNDPHVHKCRETFPEILTSFLEQIEVIIDQDGHPKHHAFVQHLQVVSSPTRTLALGPGSSWMEIDDCILLFRNNLYCLTDCPGVLMDLSDLMVCYLPSIYDFNPDNPEASSWYPLRVLLERLNAIIEVGKYRPVPYGSAQDGYKPLSPDILCWEVVPWTDPFLKQTLDAYNALVEAITARLPFPTEDQRPPLATDEFLSAEVKGFPRAFLLSASKPSFQFIAPGLTIYDVNQPPPLPRADSTTNDYDAPSMHYTEAFHDPLILFPAVGYIKEGAGLWICPDEGWADTARLVLPYVLSSYPDHTGEQVTRPSATQLWQQGECPFYVDHSTRLGTMLNQWRVLVEEGMWTVGANGVEGGVEFYRQAEDVDKAGWFCLMDDCFDLSEIAFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0K7</accession>
    <name>A0A2I2G0K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-aminoacid aminotransferase-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_361939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701717.1">
        <property type="nucleotide sequence ID" value="XM_024844489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0K7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0K7"/>
    <dbReference type="GeneID" id="36552189"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361939"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="35690" checksum="0C0188572EB64F74" modified="2018-02-28" version="1">MSTMEQIFSGYHKRLETLKSSNNPFAKGIAWVDGELVPLYEARIPLIEQGFMHSDLTYDVPSVWDGRFFRLDDHLNRLEASCGKIRLRFPIPRDQIKKTLVEMVAKSGIRDAFVELIVTRGLTAVREGNPDSMKNNLYLIVQPYVWVMDPETQKTGGSSIIAKTVRRVPPGAIDPTVKNLQWGDLVRGMFEARDRGSQYPFLTDGDTNITEGSGFNIVFVKGGVIYTPDRGVLEGVTRKSVFDVAKSKGIEVRVEVVPVQTAYDSEEIFMSTTAGGIMPITELDGKPVGNGKVGPVTRTIWDGYWAIHYDPAFSFEIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0S8</accession>
    <name>A0A2I2G0S8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribonuclease-like protein p/mrp subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_427797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701781.1">
        <property type="nucleotide sequence ID" value="XM_024847799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0S8"/>
    <dbReference type="GeneID" id="36555498"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427797"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="8">
        <location>
            <begin position="91"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="328" mass="37255" checksum="4CC7CBBC8D7175A9" modified="2018-02-28" version="1">MPRIILKRKELRESDTSESEEEETAALTTVYCGENPVIDIVAVHGLNGDAFKSFTSKKTGKFWLGDQAMLPKDMPDCRILTFSYPASVAAVFGRTSSDTILQHATTLVQELAADRQIERATERPIIFLCHSLGGIIVKRALIYSESRKAKKTEHIHSIFVSTYGIMFFGTPHHGSSKAILANYVQRMVNVLPSKVVDTGSQLLEALREGSEILQDITDNFQPKMRHFHVFFFWEQQKSNLGVKWDYIVAQTSAAPIMDDTDRAGIKADHHSICKFATRTSPGYRLVIATLMRYSDEAPSKIKRRWTETREIIRSIRRNEAREIYHESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1T8</accession>
    <name>A0A2I2G1T8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702139.1">
        <property type="nucleotide sequence ID" value="XM_024849619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1T8"/>
    <dbReference type="GeneID" id="36557318"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438542"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="63" mass="6869" checksum="BC8E4D3C6D0F539D" modified="2018-02-28" version="1">MRSDPGSGTKQEKGEGEGRRQASDRDVVYFVHVEPRPVATWPSWHPPRCGLAAPRVPGRGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G257</accession>
    <name>A0A2I2G257_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF647 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_363679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702251.1">
        <property type="nucleotide sequence ID" value="XM_024844597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G257"/>
    <dbReference type="GeneID" id="36552297"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363679"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="8">
        <location>
            <begin position="59"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="506" mass="55119" checksum="D4F3D71E3744571A" modified="2018-02-28" version="1">MNRLAFTEVDEVNHPLATYIYSEPSAPRTSSSNKDEAGRGRIDVMHPSSTVPSLWSITSLRDLLIDVFLPAGYPHSVSDDYTSLYLVFKDSLQAFSSSIAGLLSSRAVLQGVGVGNADASPTSALLLHILQDSSGRVATILFAHRVGTALEPECKMYRLAADVFNDVAMVLDCLSPMIPAGVGRVTVLSTAGVLRALCGVSGGSSKASLSAHFSKWGNLAEVNAKDSSQETIISLIGMLVGSFVVSRVTSYTATWIALVMLLTLHLSLNYAAVRSVQMTSLNRQRTNIVFSTLFESDPDFNTKGFGSSNQVKEREQDMGSDQTKWCILSPAEVARQERIFETNGILRWGSVTSSSETARIGFCRIGISVQQFLESSSSYASSGSLKTHLPVPRLSSLFKEESYILALHCINQTWYADILLKNTSDTQTQLKAWAHALLAGRVLPKSLNGDPTVDIDRILNIISTTLRFLNEGNRFDRYLLALTHAGWDVSLGALETKSGRRFISEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2F5</accession>
    <name>A0A2I2G2F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_438759</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702348.1">
        <property type="nucleotide sequence ID" value="XM_024849678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2F5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2F5"/>
    <dbReference type="GeneID" id="36557377"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438759"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="15">
        <location>
            <begin position="60"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB47046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="531" mass="58171" checksum="AADCD3C598DED9E7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2H4</accession>
    <name>A0A2I2G2H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_438804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702385.1">
        <property type="nucleotide sequence ID" value="XM_024849686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2H4"/>
    <dbReference type="GeneID" id="36557385"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438804"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF61">
        <property type="entry name" value="CAPSULE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014175260" description="Glycosyl transferase CAP10 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="246"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="542" mass="61959" checksum="A6701F09721085B9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G343</accession>
    <name>A0A2I2G343_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_466589</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702594.1">
        <property type="nucleotide sequence ID" value="XM_024852427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G343"/>
    <dbReference type="STRING" id="1392250.A0A2I2G343"/>
    <dbReference type="GeneID" id="36560125"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466589"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB47292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="413" mass="46637" checksum="C9B7B56BBFCDEEAD" modified="2018-02-28" version="1">MDLKHCVRELLFNPRHTKWIAPLLVLGDVLLCALIIWKIPYTEIDWTTYMQQISLYISGERDYTLIKGSTGPLVYPAAHVYSYTILYHLTDEGRDILFGQILFAALYITTLVVVMTCYRQSGAPPYLFPLLILSKRLHSVFVLRLFNDGLATLAMWVAILLFQNKKWAPAVIIWSTGVAVKMTLLLLAPAIAVLTVLNLSILPSLRLGVLALLVQIILALPFLQTNPVGYLSRAFELTRQFMFKWTVNWRFVGEEAFLSKRFSLALLALHVMLLGVFAATAWLKPSGSSLPDFFRTLLQGRHRGAPLSKQFVTTVLLTSLAIGLLCARSLHYQFFAYICWATPFLLWRAGVHPVLLYALWALQEWAWNTFPSTNSSSLVVVFSLAVQVFGVLVNRSNAFGSMKPRASRKEHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G375</accession>
    <name>A0A2I2G375_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_466612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702624.1">
        <property type="nucleotide sequence ID" value="XM_024852428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G375"/>
    <dbReference type="STRING" id="1392250.A0A2I2G375"/>
    <dbReference type="GeneID" id="36560126"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466612"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="64"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="250" mass="27879" checksum="BED343313D9B090A" modified="2018-02-28" version="1">MVRDCMIACPCWRMEGGSDRSRRPLIRGRDLGEINNYLHSQPPPTRIGKRPDATLIYETAPQDLRPIILSGPSGVGKGTLIQRLFDTYPGTFGFTVSHTTRKPRPGEVEGVAYFFVSPSEFSSLCSQGALVEHAYFSGNYYGTSKQTIDDQTSKGLAVVLDIEMQGVQQMKANPSIDARYVVIKPPSFEALEKRLRARGTENEEDVQNRLTQARVELDYADSPGSYDKIIVNDDIEAAYKELEMFVFGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3U4</accession>
    <name>A0A2I2G3U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIP120 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_409705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702852.1">
        <property type="nucleotide sequence ID" value="XM_024846802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3U4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3U4"/>
    <dbReference type="GeneID" id="36554501"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409705"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="302" mass="32375" checksum="053E5DE9233720CA" modified="2018-02-28" version="1">MADRQAVQQTLNSQLSKLDDPDPDMRYMSLNDLLGVLNSPSSSYLVHDQSSSTRLADGLLKALDDQHGDVQNQALKCLGPLVVRLPAESLSSILEKLSNLTASQTIDTSVPNTALRTIVTALPRPQSNQLPSAEASMAYTAVSKVLIPRLVGPTQSRTSRRGSVVKGMLEKDPSKGFSSDAIDVLIQVVTCFGPLLKEAELTALQKSVMTIIDNDTAGTVVTKRALAAISALVLHFSDSQVGAFVNELVTRFNAPQLSIVHRRHLIATVGSIARTAPVKFGPHLPTLAPYVFSAVGEDELDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G424</accession>
    <name>A0A2I2G424_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative D-mandelate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_476318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702938.1">
        <property type="nucleotide sequence ID" value="XM_024853337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G424"/>
    <dbReference type="STRING" id="1392250.A0A2I2G424"/>
    <dbReference type="GeneID" id="36561035"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476318"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="149"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="347" mass="39003" checksum="7BE4E2A6420CDB6C" modified="2018-02-28" version="1">MDDDRDIILYLGDPICYNTELYAKLEKEFIILRPSKKERERDEFIKALKEKRWCEFSAILRPFCDSGWEMGKWNTALIHLLPDRCSAFASAGSGNEGIDLKVMKMQGIEYYNGAAAASEATGDMAIFHIIPVFRNMQWSIEGALSIDPNRWKDAHRNAARTAYNPSGKALGIIGLGQVGSTIARKAFGCFGMKIYYHDIKRKRKNEEEALKVEFCERLEGMLEIVDCVVVATPVLPTPIITKATLWRFKKGSRLVNIAHGSSVDEEALVGALETGHLSAAGLDVQEKEPYVHPKLAVMRNVTLTSHTAEGTIDTEIAFETLAMENIRQHFLAPSDFQSLCQKYPMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4E3</accession>
    <name>A0A2I2G4E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_447651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703040.1">
        <property type="nucleotide sequence ID" value="XM_024850900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4E3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4E3"/>
    <dbReference type="GeneID" id="36558599"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447651"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF7">
        <property type="entry name" value="CELLULOSE SYNTHASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="537" mass="59676" checksum="7BD1E959A35F15FF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G559</accession>
    <name>A0A2I2G559_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_465483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703285.1">
        <property type="nucleotide sequence ID" value="XM_024852328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G559"/>
    <dbReference type="STRING" id="1392250.A0A2I2G559"/>
    <dbReference type="GeneID" id="36560026"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465483"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="144" mass="15656" checksum="30372CC79144422D" modified="2018-02-28" version="1">MSLEPFFTALSVAQSGAQYTPEVQSAAAGINADLLKVAVELVLAGDDSASVEGEQATALKAGFEFATKVVKMLEKEPGQTEMLTLYKYFKQARGEKPAEPSFYQIESKYKYNAWKEISGISAAKAQAQYIKEVAALIEKFGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5G2</accession>
    <name>A0A2I2G5G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fuconate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_410732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
            <dbReference type="ChEBI" id="CHEBI:37448"/>
            <dbReference type="EC" id="4.2.1.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.68" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703406.1">
        <property type="nucleotide sequence ID" value="XM_024846856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5G2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5G2"/>
    <dbReference type="GeneID" id="36554555"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410732"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="7">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="452" mass="49868" checksum="298D81ABFC83906B" modified="2018-02-28" version="1">MVKITGFTTRDVRFPTSLDKTGSDAMNAAGDYSAAYCLVNTDSPHIGHGMTFTIGRGNEIVCSAISLLAPLVVGKDLDELTADWGKTWRYLVSDSQLRWIGPEKGVIHLALGAVVNALWDLWAKTLGKPVWRIVAEMSPEEFVRCIDFRYITDAITPEEAVALLKEVESGKQERIKEAEQSRAVPAYTTSAGWLGYGEDKLRALLSESVTQGYKHFKLKVGGNLEDDKKRLSIAREAIGYDKGNILMVDANQVWSVPEAITWMQELAEYKPWFIEEPTSPDDILGHAAIRKALENTPHGTIGVATGEMCQNRVVFKQLLQAGALTVLQADACRVGGVNEVLAILLLARKFGVPIVPHSGGVGLPEYTQHLSTIDYVVVSGKKSVLEYVDHLHEHFVHPSSVRDGYYVTPLEPGYSVEMKPESMDEFAFPGEEGKSWWRSEAAKPILEGPRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5G9</accession>
    <name>A0A2I2G5G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_437822</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703416.1">
        <property type="nucleotide sequence ID" value="XM_024849454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5G9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5G9"/>
    <dbReference type="GeneID" id="36557153"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437822"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="113"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="472" mass="53138" checksum="5DDA76DC61F828BA" modified="2018-02-28" version="1">MSSKSRWADDDPETEAIVAQRKREKEEKRRAKAEKQRQLEQRQSQPQPPSETNGDTDAPPKKRRRLSNEPAEDQELPESADPGNEKQQASRVKSKLLRFPGQGWGPCRHVDNFERLNHIEEGSYGWVSRAKDIVTGEVVALKKLKMENSPDGFPVTGLREIQTLLEARHKNVVYLREIVMGNKMDDVFLVMDFSEHDLKTLLDDMREPFLPSETKTLMLQVLSGLGFLHSQWIMHRDLKTSNLLINNRGELKIADFGMARYYGDPPPKLTQLVVTLWYRSPELLLGAEKYGTEIDMWSIGCIFGELLTKEPLLQGKNEVDQVSKIFALTGPPTAQSWPGFRSLPNAKSLRLPPTSDSSGSLPLLPRSKFPFLTNAGLHLLSSLLALNPSIRPTTQECLSHQYFREDPRPKPKEMFPTFPSKAGMEKRRRRETPEAPKRGQDAPKLDFASVFGGGQAGGDTGETGAGFTLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5J1</accession>
    <name>A0A2I2G5J1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_207102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703448.1">
        <property type="nucleotide sequence ID" value="XM_024842791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5J1"/>
    <dbReference type="GeneID" id="36550489"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_207102"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014178293" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12451" checksum="445CEF121678D9A7" modified="2018-02-28" version="1">MQSLLQLSADVVVFCFKLVGLCQGDVMPPGDQSRQRRSQKTMSEFPARLDSGLVGAVAELRGGSRSHQGTLCGLVGERLFPPNRRRSVDRQGPRHRLLTPWCSSSFRVGLEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5M4</accession>
    <name>A0A2I2G5M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_465629</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703479.1">
        <property type="nucleotide sequence ID" value="XM_024852333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5M4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5M4"/>
    <dbReference type="GeneID" id="36560031"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465629"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014192157" description="Probable beta-glucosidase G" evidence="19">
        <location>
            <begin position="20"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="717"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB48177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="803" mass="88054" checksum="9AD100937BA0E2AE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G600</accession>
    <name>A0A2I2G600_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_510938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703606.1">
        <property type="nucleotide sequence ID" value="XM_024854830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G600"/>
    <dbReference type="STRING" id="1392250.A0A2I2G600"/>
    <dbReference type="GeneID" id="36562536"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510938"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="634" mass="69097" checksum="54653412DB4179FF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6P3</accession>
    <name>A0A2I2G6P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucoamylase</fullName>
            <ecNumber evidence="10">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_411426</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703841.1">
        <property type="nucleotide sequence ID" value="XM_024846890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6P3"/>
    <dbReference type="SMR" id="A0A2I2G6P3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6P3"/>
    <dbReference type="GeneID" id="36554589"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411426"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014167047" description="Glucoamylase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="14">
        <location>
            <begin position="505"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB48539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="611" mass="65263" checksum="4F39AD13E8F1293F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6V2</accession>
    <name>A0A2I2G6V2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_165870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703904.1">
        <property type="nucleotide sequence ID" value="XM_024842596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6V2"/>
    <dbReference type="GeneID" id="36550294"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_165870"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="17891" checksum="AA7B0A22F9E88C92" modified="2018-02-28" version="1">MDSPRRPRRMDPGRVIGGSALNQTWSSEDNPETLGSAVADQPKSRQPVTSWTGQSAGKDRQAAGTSVATPLSPVALRIERPRRFPTMRATLMSCWPLRALRWPAAAGAFHGLKLPGMTVRPDRMARTLSEGERESDRKRKANKHCGARMKDGKSKTCLISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7R4</accession>
    <name>A0A2I2G7R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_509585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704221.1">
        <property type="nucleotide sequence ID" value="XM_024854692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7R4"/>
    <dbReference type="GeneID" id="36562398"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509585"/>
    <dbReference type="OrthoDB" id="3434980at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="72" mass="8416" checksum="738E7FE10548B223" modified="2018-02-28" version="1">MSKRIYYTYKTIEAWETHDEEVRKIITEDTKTDNWICNRALPPTCYPPPLSAEAIEKIKKLSDDIVVGEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8Q2</accession>
    <name>A0A2I2G8Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_436839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704525.1">
        <property type="nucleotide sequence ID" value="XM_024849236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8Q2"/>
    <dbReference type="GeneID" id="36556935"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436839"/>
    <dbReference type="OrthoDB" id="5238363at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="172" mass="19593" checksum="ED51452BDC7213A9" modified="2018-02-28" version="1">MVLRTRLFTIKYNPRTQIPPVAARYLGSPANPIHPKIAHMYATRDRTELWWRVSAQHLMAYKRVVRNLCLRHIRFAFRQALKDRGFDANGKRIAPATPSPEGQKLPGDAPLTGTVEIVINPRMPREDFSNLQSDMNQTVDNLLRQTQEKKAQIPQRGAGGKRSKWVELAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8U0</accession>
    <name>A0A2I2G8U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative extracellular dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_356474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704604.1">
        <property type="nucleotide sequence ID" value="XM_024844151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8U0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8U0"/>
    <dbReference type="GeneID" id="36551851"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356474"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014196450" evidence="2">
        <location>
            <begin position="22"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="381" mass="40439" checksum="17C25BDE15D4F0DF" modified="2018-02-28" version="1">MVHLTPALVAGLVGLAGLAAAHPGHDVKAEAAERAAFLKRAPVHHRSLNHCTEKLRARGHEARNVARRELTVERLRRRKGLETRSTYLKARDLDEALNTSHHSSLDVDQTVDPAVLFASNATCILGPDTTQGPYYVTGELIREDISEDQAGVPLFLDFQIIDTNTCDPVPNIYIDAWHCNATGVYSGVVAGGNGNQGDDTNLDATFLRGVQKTDTSGVAQFETIFPGHYTGRTHHIHLLSHAPNGTTVNANNTLSDLFTAHASYVGQTFFDQDLIYEVEATTTYAANTQPLTTNADDGILAEEADVIDPFMQYVYLGDSVEDGLFAWISLGIDGTKSSDVAPAVWYTENGGIENPNSGGGGPGGPGGPGGPGGPPSGVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8V6</accession>
    <name>A0A2I2G8V6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_426241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704603.1">
        <property type="nucleotide sequence ID" value="XM_024847698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8V6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8V6"/>
    <dbReference type="GeneID" id="36555397"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426241"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="158"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="600" mass="66346" checksum="7D087FC5F57E222A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9A5</accession>
    <name>A0A2I2G9A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative alpha-1,2-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_426371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704761.1">
        <property type="nucleotide sequence ID" value="XM_024847704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9A5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9A5"/>
    <dbReference type="GeneID" id="36555403"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426371"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF5">
        <property type="entry name" value="(MNN2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="496" mass="56138" checksum="690EDC32C3BE7B11" modified="2018-02-28" version="1">MFLPRPLSRVRTLLLALILASILTWSARNWRQQLVSQATVSTDGTSSPSNPQNAVWQDIQGHIRFWRHLQHLLAVNEPKGEPPLRLGSAPSIRFEEANPDDRPEMLDMLPEDVEAMKEAHGVFVEEIKKNPPQLHYAPNTRGLVSTAGGSYLPVLVISLRMLRKTGSELPVEVFLADEEEYEDYICDVVLPSLNARCVVLSHILDAVPKIMEIQKYQFKLFAMLFSSFEEILFLDADAFPLRQPESLFTSEPFKSKNMVTWPDFWASTVSSYYYEIASQPIPEKAIRQSSESGEVLLSKKTHLKSLLLSTYYNFWGPDLYYALLSQGAAGEGDKETFVAAALALEEPYYQVSEPICAIGHRIEGGMAGSAMVQFDPVEDYALTQKGEWRVHGSKAPAPRAFFIHANFPKFNPATVFENQAVNPAFDESGSYTRAWTIPENVIEEFGTDVERQFWKEILWTACELETKFKSWDGRSGICKGVKKYWNAMFLDPKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9G6</accession>
    <name>A0A2I2G9G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_426422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704823.1">
        <property type="nucleotide sequence ID" value="XM_024847707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9G6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9G6"/>
    <dbReference type="GeneID" id="36555406"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426422"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="277" mass="30937" checksum="95D87AF7FB9AD975" modified="2018-02-28" version="1">MADYPAPSVHVQNLSYQFQDGSSGLTNVGLQVPSGSRTLLIGANGAGKTTLLRLLAGKRLAPKDTIFVGGKDPFKDGLEGVTYLGMEWVLNGIVRSDIDIPTLLASVGGNAYPERRDELVDILDIDLNWRMHTVSDGERRRVQLAMGLLRPWQVLLLDEITVDLDLLSRSNFLAFLKRETETRPCTIVYATHILDNLSHWPTHLVHMHLGNVRQWGPMEKFQGEVPETSQNSQLGELVLKWLREDLKARGPRNGRHGQGKTYESLEGKGGYGFEKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBA1</accession>
    <name>A0A2I2GBA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_354000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705456.1">
        <property type="nucleotide sequence ID" value="XM_024844004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBA1"/>
    <dbReference type="GeneID" id="36551704"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354000"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="263"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="577" mass="64986" checksum="878954A193887EBC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBJ6</accession>
    <name>A0A2I2GBJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative WSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_140272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705561.1">
        <property type="nucleotide sequence ID" value="XM_024842462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBJ6"/>
    <dbReference type="GeneID" id="36550159"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_140272"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014129670" evidence="7">
        <location>
            <begin position="27"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="280" mass="29643" checksum="1E3EB1D3F7506EE5" modified="2018-02-28" version="1">MKSFTMRSAVALSALLVAVGLPAANAADEVSKGCYSDATPLEDQGAYTYQSDGYCQKLCLDDNYSVFALTGGTHCLCGNKLPADSAKTSDSNCDKGCAGWPDVKCGGKDAYSVYLTGLKDNVEKYSSSSSSTSSTESESSTSTAEGHMSTKAGHTVFVTSASQTGADAAAEMNKEDKKDSGPNTAAIAAGVVVGVVGFCALVGAIFFLWRFRNRKAAENQYRRSVGVDNYGGKPMSQSSMSDSRFDGDFMAQRRQSNGSIDDDQDFSRRILQVTNPDRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCE0</accession>
    <name>A0A2I2GCE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylate/malic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_405755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705844.1">
        <property type="nucleotide sequence ID" value="XM_024846597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCE0"/>
    <dbReference type="GeneID" id="36554296"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405755"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF3">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="490" mass="54792" checksum="E3769B2CB8AB4445" modified="2018-02-28" version="1">MDSFENAMDIQHSRPRHLRSPGDDGYRTPTIEDTEKDLALQDNALSLLSGKRTREAHSSALEALHRSWTRKSQERGGAREEEEEATRRPSFSFRPSDRSAINLGWRKRIRHLTWAFFTLTMATGGIANVLYTIPYRFRGLDTIGVIFFLVNIVFYTVIWCLLIARFYFYPYTFKASFLHPTESLFVPASVVSFGTILINISQYGPDNTGPWLTHAVGILFWIDAALAVIFAAGIYLLLWSTQTFTIAQMTPIWIFPAYPLLIIGPHAGVLSSKLEPSRSLPIIIGGTTIQGVGFLVSLMVYSAFIYRLMSQKLPRENVRPGMFVSVGPSAFTVSGIVNMAAQAHRCFPNEFMGNGPLAADIVKVVVNFGSLWLWGLAIFFFFIASFAHWSAIGPGRMEFSMAWFSFVFPNTALITATFAIGNAFACKPILIIGCAMVIPLILMYVFVFGMMVRAIVLRQIIWPQKGEDKDEGGFEINRIKPESAGEPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCP6</accession>
    <name>A0A2I2GCP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-mandelate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_435825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705944.1">
        <property type="nucleotide sequence ID" value="XM_024849028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCP6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCP6"/>
    <dbReference type="GeneID" id="36556727"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435825"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="144"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="198"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46828" checksum="561B64E3A246A45A" modified="2018-02-28" version="1">MTYQASQEPLNQSYQIKSELLSFPNFFLPSESFPALLDRLIADANGFLSGVDQHHRSLRRTIITISTPDPPTSKMPNPIILHLGDPIKYNHDFYNGPFSDRYDIVPNDAPDRGSFIHALKTNRYGSFSAIFRPHFQSGGEMGQWDDELIALLPSSVRIFASAGAGFNWADVDALGARGIWYANGAGASDEAVSDTTLYMILSVFRNFTRAQIAARTADPARFTATHKLLAMISRNPRGHVLGLVGLGNISKRVAEKARALGMEVMYFDVVRAEREEEERLGVRFEGSLEALLEKADCVSLHTPLNEHTRHLINERTIAVMKDGARLVNTARGEVVDEEALVAALETGKLSAAGLDVHYHEPQVSKRLAAMENVTLTTHVGGGALETRINFELNAMRNILAVVGEDGQVIGEPLTPVNAKAVRDSHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCS3</accession>
    <name>A0A2I2GCS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosinase central domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_151545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705991.1">
        <property type="nucleotide sequence ID" value="XM_024842521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCS3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCS3"/>
    <dbReference type="GeneID" id="36550218"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_151545"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="298" mass="33075" checksum="22D2B9992076EA4F" modified="2018-02-28" version="1">MQEKPGQLPTEHYPGARSRLDDFAITHINSTLGIHFNGVFLSWHRHYLWLWEKALKEECGYEGNQPYWNWALSAGDLGSSPEFDGSPTSLSGNGDPSVPYPLSDPAANATGGCVTTGPFANTQVHVRDLNAFRTSDVILPSFFDYEPRCFARQFNDTSSGLYLNQGAVDRLLDSPDIRAFQFNMDGREAREFPPGGFVGPHSAGHQSLGPIMGDFFGSPQDPSFFLHHGMVDRTWALWQAKDEENRLTQTYGTSSIFNDPTTPNVTMDTQLSFGILSEPKTVGELVSTHAHDLCYEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD78</accession>
    <name>A0A2I2GD78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitro/flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_463908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin oxidoreductase frp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706124.1">
        <property type="nucleotide sequence ID" value="XM_024852199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD78"/>
    <dbReference type="GeneID" id="36559897"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463908"/>
    <dbReference type="OrthoDB" id="2094932at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02146">
        <property type="entry name" value="NfsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016446">
        <property type="entry name" value="Flavin_OxRdtase_Frp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43425">
        <property type="entry name" value="OXYGEN-INSENSITIVE NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43425:SF2">
        <property type="entry name" value="OXYGEN-INSENSITIVE NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005426">
        <property type="entry name" value="Frp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB50822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="280" mass="30569" checksum="7DFBD88ACACD6DA7" modified="2018-02-28" version="1">MSSVPNTTFSSLVEARYRDGQSIQRPLPNDFPPTLQTILNHASCRSFLPTPLPTGTLEALMAAAQSGSTSSMLQTWDVIAIQDPSHKSAVATLAGDQEFIRQAPLFLVFCANLHRLANISRRYDQPGRALANTDMFLMASLDAAIAGQNTAIAAESLGLKICYVGAVRNNAQQMCELLGLPHNVVGVFGMAVGYGEEEPTGGIKPRLPMREVCHREVWSEEDQEENIQVFDEALGAFYAGVMKLGRDGWSKFVAGNMASVEQDGRENLKETLYKQGFKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDA6</accession>
    <name>A0A2I2GDA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_316896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706155.1">
        <property type="nucleotide sequence ID" value="XM_024843289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDA6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDA6"/>
    <dbReference type="GeneID" id="36550989"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_316896"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055497">
        <property type="entry name" value="DUF7069"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23239">
        <property type="entry name" value="DUF7069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="324"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7069" evidence="4">
        <location>
            <begin position="516"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="812"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="846"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="880"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB50853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="970" mass="110838" checksum="0C3F3CE36FF44E64" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDF9</accession>
    <name>A0A2I2GDF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_493093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706231.1">
        <property type="nucleotide sequence ID" value="XM_024854041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDF9"/>
    <dbReference type="GeneID" id="36561746"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_493093"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="300" mass="34484" checksum="3D1B1EA97F97DC5E" modified="2018-02-28" version="1" fragment="single">SSTASITSTILNYQYVHKNGRRYHAYRQGEYVIPNDEQEQERLDLHHHICSLAMRGDLYRCPLPQGIRRVLDIGTGTGAWVIDMADSFPETVVIGTDLSPIQPLWVPPNCVFEIDDFELEWNFSQPFDFIHARAIEGCVHDFPRLFQQAYDSLSPGGWFEVVDFTAGIFSDDESTEKSPHLLEWRDRLIEASRVFGKPMGVASQYDEWMAQSGFANIRQEIIKVPFGPWARNATQKELGRYHQTNMLEALEAYSLALCTRYLGWSVEQVQLLLIGVRKELKDLSLHNYSKLYVVYGQKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDZ5</accession>
    <name>A0A2I2GDZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_159471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706382.1">
        <property type="nucleotide sequence ID" value="XM_024842558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDZ5"/>
    <dbReference type="GeneID" id="36550255"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_159471"/>
    <dbReference type="OrthoDB" id="4154127at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="97" mass="11320" checksum="359390790F62B5DB" modified="2018-02-28" version="1">MECFRQIVRLVKSPFQRDSQQQHKVLEIGPPTNFRKEELPAFFSDDDALTLHSNGSANEKEAVITSMERQPSTRDKIKNHVRRLSVKTHRPLPEHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFC3</accession>
    <name>A0A2I2GFC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_433499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706884.1">
        <property type="nucleotide sequence ID" value="XM_024848502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFC3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFC3"/>
    <dbReference type="GeneID" id="36556201"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433499"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="197" mass="21756" checksum="243CD9264DC9CF84" modified="2018-02-28" version="1">MADAAPRGRGGFGSRGDRGGDRGRGRGRRGRRGGAKQEEKEWQPVTKLGRLVKAGKITSMEQIYLHSLPVKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAVVVIGDSEGHIGLGIKTSKEVATAIRAAITIAKLAVLPVRRGYWGSNLGEPHSLPVKQSAKCGSVSVRVCYEFLRLLRSWPCDQTLTMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFJ5</accession>
    <name>A0A2I2GFJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_422603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706909.1">
        <property type="nucleotide sequence ID" value="XM_024847448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFJ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFJ5"/>
    <dbReference type="GeneID" id="36555147"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422603"/>
    <dbReference type="OrthoDB" id="5426977at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014143357" description="PD-(D/E)XK nuclease-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="266" mass="29938" checksum="99F53394224BED00" modified="2018-02-28" version="1">MTQLARSLILLIAQAPDEAIDIPDAAFYDAANSTPEELYALWQDVTEIYNEAAEAEEHGQDENAWGSGVIQAVLQRGVKRRILQVKNVQTKNIDPCLLPRLPHKNAVSKKVDYTFAFSVRDPQVKETYNNFWNAFPDQTVSQTTDPFTKRVALFSGIEVKQSNGGNTEALVQLAIWLAAGLEKLSRLRDLHGEKSDRSSYQASDGQGCFEGQDRIYVDGPVESLSASTRTYYGIFKLINLVHKLSLYAEEVYWPWMKSDILTRTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG21</accession>
    <name>A0A2I2GG21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Swi5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_471758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707135.1">
        <property type="nucleotide sequence ID" value="XM_024852866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG21"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG21"/>
    <dbReference type="GeneID" id="36560564"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471758"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000056">
        <property type="entry name" value="DNA repair protein SWI5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10708" checksum="E7F15D1BA3DDACDA" modified="2018-02-28" version="1">MDAHLAQQAQRGHRLHTLRASIADLESQTAQVEAQIAGIKAKLKSDPSTTVQRHIRLLHEYNEIKDIGQGLMGLIADARGVRQIEVQREYGVADRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG75</accession>
    <name>A0A2I2GG75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mitochondrial large ribosomal subunit protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_401566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707188.1">
        <property type="nucleotide sequence ID" value="XM_024846375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG75"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG75"/>
    <dbReference type="GeneID" id="36554074"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401566"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="305" mass="33709" checksum="75D76B3B4461858A" modified="2018-02-28" version="1">MSSYNSLLPSAARGLLSSCRLPLRQSPMVPVFSSVPQQVRGIKSNNPQAQAKRAKEKTKKTTKKGPRIFKQSDIKSAQQFSLCEAMRYLRAFEVGREPTAIKYEIHVRLRTQKDGPVIRNMIRFPHSVQTESRICVVCPPGTRHEKEARAAGAVLVGEQEVFDAVKEGRIEFDRCIAHPDSLPALNKAGLGRVLGPRGLMPSAKTGTVVEDVASRVEMLRGGTVYRERDAVIRFPIGQMAFTPEQLRDNLRTTIEQIKKDAAGLNDRINKEIYEVVLSSTNGPGFSLTGDFKPDDSFDTASLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG98</accession>
    <name>A0A2I2GG98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_433810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707211.1">
        <property type="nucleotide sequence ID" value="XM_024848580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG98"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG98"/>
    <dbReference type="GeneID" id="36556279"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433810"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="717" mass="80942" checksum="C4B0965214871158" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHD6</accession>
    <name>A0A2I2GHD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF292 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_434087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707591.1">
        <property type="nucleotide sequence ID" value="XM_024848642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHD6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHD6"/>
    <dbReference type="GeneID" id="36556341"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434087"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="407" mass="43871" checksum="B60075FBA07680D2" modified="2018-02-28" version="1">MPPSPQTTKLTSTLHLLIPRLRLLQKKSTASSVVQRRELSHILSEGREASARIRVENVIATDISVEVLEMVELYCELILARANVVDQAAFGEKGVLARNRAKEVWSSLRHAQGQGQGQAAGDGKGRGQAQQKSGFSFWNPFGGSSSNKPSGPVGAESPKAETEETLAATDEDLEVLESKYIDPALDEAAAAIFYAYPRFPHDVRELTILRTLLADRWGKDFMALAADNKFPAGEGVKVPARLVKGLRAKPPSTELVESYLLEIARAYGVNWGEHLQGHPDPELGEAPAEFVDGDEAEFKENRDDGTGPGDDEGPGDLPSTPAKLQRRQSDTAELNRVTPPRGLQAGKSPVSVAPPGPRSDNPNPRVKVPGSGSGKETVPETQSPSKSKSGGIPELDELTKRFAALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHJ6</accession>
    <name>A0A2I2GHJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_507155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707652.1">
        <property type="nucleotide sequence ID" value="XM_024854456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHJ6"/>
    <dbReference type="GeneID" id="36562162"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507155"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="545" mass="59205" checksum="D7FC3B5754EADC7A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GII1</accession>
    <name>A0A2I2GII1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA dihydrouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_434414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707994.1">
        <property type="nucleotide sequence ID" value="XM_024848707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GII1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GII1"/>
    <dbReference type="GeneID" id="36556406"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434414"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="96"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="439" mass="47820" checksum="89325D83194508A1" modified="2018-02-28" version="1">MTSLSAPPRVPIPANGVDYRGKLVLAPMVRSGELPSRLLALRYGADLVWGPETIDRAMIGTTRRVNPRNGTIEFFRRPSNGGRTDRPVYDSIIYRIDPVREKGKLIYQIGTASPELAVEAAKIVAGDVAGIDVNSGCPKPFSTSGGMGAALLRTPDKLCAILEALVREVGNPFQIGISVKIRILDEPEMTEQLVTRLVKTGITGLTVHCRTTPMRPRERAIRDQLRMVANVCHEAGVACVMNGDVTSRDQGLALMEEYGVDGAMIATSAESNSSCFRTEAEGGLLPWKDVVHEYMRFCMESENRFGNTKYLLNMMIPGRDKEFKAAKNARTYWDCCHLMKFDDLLPLAKQVDEVLNIADRSVYNEEARNKAVQNALENNDTARAAGGAPRSKPTSPVVAAAGGPIRTNSIPKPAPKPETTAGIETTVPEQTTQQPELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ11</accession>
    <name>A0A2I2GJ11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_472760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708172.1">
        <property type="nucleotide sequence ID" value="XM_024852980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ11"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ11"/>
    <dbReference type="GeneID" id="36560678"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472760"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000030">
        <property type="entry name" value="Mitochondrial large ribosomal subunit L49, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="26508" checksum="E89114BDA79B9ABA" modified="2018-02-28" version="1">MWAGGLVGALVPMGVSGRSPRKEDPESVKVSPSRFLASFSSSSLLSPPVIAMASFLQSRPVLSAVRKQSTAVPFGLQTSSQSMLSRSGTCSSFSSLCSSTRSTNSQNPRQSLSSTVPTQQSRTFLVQFRRQSQSLKENPPSKFPPADLQLTNLPYFIRRTPSNQLPVYLITKAGGTKQQTKLQKTEGDLDALRKDLAQFLGLESGDPAAPQSPDVAINRLTGHILVKGWRKPEIQQFLLQRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ81</accession>
    <name>A0A2I2GJ81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CLU1</name>
        <name evidence="4" type="synonym">TIF31</name>
        <name evidence="8" type="ORF">P170DRAFT_403608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ81"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ81"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403608"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000532">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="7">
        <location>
            <begin position="314"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="976"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1219"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1248" mass="138286" checksum="429237CF0FAE963E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK86</accession>
    <name>A0A2I2GK86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_404306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708596.1">
        <property type="nucleotide sequence ID" value="XM_024846520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK86"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK86"/>
    <dbReference type="GeneID" id="36554219"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404306"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27526" checksum="32E5730BA68E0D76" modified="2018-02-28" version="1">MTGVVHEIGEGRVVKKAKQSQLRDAGDAEYMNEVNQKILENELLVFERLGSHEGIIPCFQTSRYGIELARAQDDLECYLEKHPEREDTLKIEWIIRLIKTFAYIHSRRVFVDDIALRNILIIDEQLNVADFGQSILLPLDADPASANENDLNARIEILHLGWILYSIASWQVHKYYFFGAENPDLCWPTSWPNVEYVVFGQIIKKCWHGEYASMDHVELEARQLFAGYQPETVNWEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKG0</accession>
    <name>A0A2I2GKG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_435009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708668.1">
        <property type="nucleotide sequence ID" value="XM_024848850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKG0"/>
    <dbReference type="GeneID" id="36556549"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435009"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="69" mass="7557" checksum="B3B270AC60CA34CD" modified="2018-02-28" version="1">MVPSSEMGMINVSVALTICITLPCGFYASRIGEAKHSLSSQHSGFPGSHAFYLKRVQKARLIRDALNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKQ4</accession>
    <name>A0A2I2GKQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_508077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708763.1">
        <property type="nucleotide sequence ID" value="XM_024854532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKQ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKQ4"/>
    <dbReference type="GeneID" id="36562238"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508077"/>
    <dbReference type="OrthoDB" id="4510389at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="3">
        <location>
            <begin position="178"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="41396" checksum="D43D98E31A416D46" modified="2018-02-28" version="1">MSAITVPDDAWSQGLPALKDSIQIHLTESETKFEEAMVHAAFHFVVDSVQQLKHDDRDDWEWHRRVMYDWMLETIELGNGGAIAPGSEAWAKESPQVRSGLVEYLEATENVSARLTVRVGQNLVKIFRDEMTPLELVMEDNLLNRYYMEYPKLKDRSYKHLRRAVELYARARPDARILEIGAGTGGATKIVLQSFDTVIEEQDEDRYPEYTFTDISAGFFLAAKSKLAAWAPDMDFQKLDIESNPQDQGFEPGQYDLVVASLVLHATKSLHRTLTHVRQLLKPGGKLFLVETTRDVTDMQLIFGLFEGWWLSEDNRKSSPNAPTHVWDRVMRETGFTGVDFEIGDCEEAIYQSTSLLVTTASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKZ7</accession>
    <name>A0A2I2GKZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_445263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708839.1">
        <property type="nucleotide sequence ID" value="XM_024850689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKZ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKZ7"/>
    <dbReference type="GeneID" id="36558388"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445263"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="495" mass="57735" checksum="1CC9209B320457C5" modified="2018-02-28" version="1">MQLSISSLWAFLGLLTLYLVVRSIYRLYFDPLSHIPGPKLSILTDLYEFYYDLVLGGRFLFHMEKWHEQYGPIVRINYREVHIIDPEFYDEIYAGGIRRRDKDPKFITGFGLPTSMVATVGHDHHRFRRNILNNFFSRRSVQELSPMIELRVQQLVQRLEEFHHDQTPVCLDDAYAALTSDIITHYCYGRSWGYLETKNFHSDVREVLKDVTGFVHINRCFPWFTGLMRMVPERLMRFMQPGKRVMFDIQRAIYQHALEEGTEPLTKGEKPQRANMFEQLNDPSLPAEERTLQRLQEEGITLLSAGTETTARALTVATYHLARDNEIVQKLRSELKTVLPTPTSRATWTELEKLPYLTAVVHEALRTAFGLVIRLPRVAPTEVLQYKDYTIPPGTPVSSSAYFIHRDPNIFPEPEKFKPERWIRNGEFDRGLTRYIVSLAYLELYMAFAYLLRRFDFDLHETGPANVRITRNMGVGFTDNYDFKVSAKVVGMVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLB0</accession>
    <name>A0A2I2GLB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_504586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708941.1">
        <property type="nucleotide sequence ID" value="XM_024854212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLB0"/>
    <dbReference type="GeneID" id="36561918"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504586"/>
    <dbReference type="OrthoDB" id="4503512at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36022" checksum="D5FFF282F8AD7F6E" modified="2018-02-28" version="1">MATEYLYRVCIEYVKVFVRDLLSSVATIHGAYSIISEKGLTEIVSCTLKCLDLEVLVYDRLCAELDDPNPESCLRQCSDPEDEQHLTQTLVSLCQLVDTSSLSLDENRLYRRDLITPPTDTPTGKGHTRTRAPPKITSASPTHKITTLTELTNPPTTSPSASSQKTTNGPLPTSLITSASPSTLTESSPTPTSSSALPQATQSPKSSTSLSPGAIAGIAIGGVLLCVILLIALRCCVIRRRRALHQQGNENKAKPLPLITSPEIPEKHGNSINEIDGRVTAYPPGPIHDAIFELGGDPVVESRSEISDTPKFSVIETEGNKRRGETRSDEPRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLU0</accession>
    <name>A0A2I2GLU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_343437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709149.1">
        <property type="nucleotide sequence ID" value="XM_024843402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLU0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLU0"/>
    <dbReference type="GeneID" id="36551102"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343437"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="12233" checksum="360F0B10307306E1" modified="2018-02-28" version="1" fragment="single">SLLGSTSIYYIYLQYLVYLRFNSCILSLAKLSLLWTVIFLIYIINIIITNITGLQNLQQYITCAVYLSLINLCLLFLSSGREFGIYLLGISQETYSIVHCITGFIAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMF1</accession>
    <name>A0A2I2GMF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_431739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709355.1">
        <property type="nucleotide sequence ID" value="XM_024848107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMF1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMF1"/>
    <dbReference type="GeneID" id="36555806"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431739"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF1">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014197829" evidence="4">
        <location>
            <begin position="23"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="406" mass="45410" checksum="9C9CEE8EA1BD0090" modified="2018-02-28" version="1">MSSIHNVAIIGAGLSGLTLALALHKQSIPCTIYEARSAPLDIGGAIMLSPNALRILDTLGIYDRIRADGYDFDELHFRSVSNEPVDVYEFGGTEKYGYRGMRIYRHILISQLSALVQEFNIPIQYNRKLQEIVSETPTSVTWSFADGTTETVTCLVGADGIHSRVRKYLYPDLEPLFTSMMGVTAAVSTANLQVPDGYQLPVTIMNPQHGAFVIAPQKKDGSEVLIGRQKRAPELDRAGWNALMNDTDWCVDFLREAADEFPEIVQNAVSDISPSKINLWPFYVVPKLERWNSEHSRVVILGDAAHAIPPTSGQGVNQAFEDVYTYSLILAKLDESSLDKTLKAWQRGRQERVDKILELNGQIDKRRMPTQGVLDKVETGGKFDLGWLYKADFEAMVKEWLHKDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMG6</accession>
    <name>A0A2I2GMG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Neutral protease 2</fullName>
            <ecNumber evidence="16">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_451922</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="16"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709369.1">
        <property type="nucleotide sequence ID" value="XM_024851236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMG6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMG6"/>
    <dbReference type="GeneID" id="36558935"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451922"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF7">
        <property type="entry name" value="NEUTRAL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="13">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB54067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="202" mass="21648" checksum="5D6E95C373B8E05D" modified="2018-02-28" version="1">MLALLLAVCLAVANPLDKRASLVHCTTEQKSMVQNALIQSSRMAQAGASAIRSGSSYGNNLFQTFFKTTDESSKSHVANILDQIAEEAQARGSGRVTYSCTPDGIPCSDSESFTVTAYGETDGYNGDIRTCPAYFSIPSFSNNCDALDQATSTTHEMAHTKGIYGIETYGYYAVQGLDSQSALINAESYAFFSKAALLHCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN82</accession>
    <name>A0A2I2GN82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709644.1">
        <property type="nucleotide sequence ID" value="XM_024848161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN82"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN82"/>
    <dbReference type="GeneID" id="36555860"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431973"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="135"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="300" mass="33625" checksum="12DF40CE5366BD1E" modified="2018-02-28" version="1">MRLPRASPRAQFSCLASNNPRLSGFRPLDCLDHVDVDKFRERCMLPEFPIVLPRGHFDAFPARQRWFRSSPSQLNTEYLQQHGADAFVPLELTQSLSEPSGQPGPPRSEEVGFRKFHAPLGLFLEWMRAAETQSPTTRLYLAQCQLLDLPQTLRDDFPAPPLVSQAGRGDIYDTNLWIGHPPTYTPLHRDPNPNLFVQLAGQKVVRLIAPDQGQAVFASVRRELGRSSDHGAAAFRGEEMMQGQERALLEAAVWGTSSGGCEGYEAHLEAGDGLFIPKGWWHSIKGVGQRVTASVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNI9</accession>
    <name>A0A2I2GNI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_397885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709732.1">
        <property type="nucleotide sequence ID" value="XM_024846195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNI9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNI9"/>
    <dbReference type="GeneID" id="36553894"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397885"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000018">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="273" mass="31090" checksum="434AE4C6F45D00C3" modified="2018-02-28" version="1">MSFDRLNSLESQPTTMRRSDDPQYRDDPDFHRLTEALSNQLFGLTSNITRLSDQIALLGTRRDSERVRERVHNLLEQARSGFKEVGEGIKKVQTWEDVNPSQKWTQQKLSSEFKATLEEFQTVQRRALEKQRASAVAARTAVDEGEVPPEDAEAYHQQQVQQLEQQPRLANQDEVDFQETLIIEREAEIRNIEQSVGELNELFRDVAHIVHEQGGQLDIISENVERVNTDTRGANVELRGASRHQKNARNKACCLLVILAVILLIIVLAATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPA5</accession>
    <name>A0A2I2GPA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_452405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710007.1">
        <property type="nucleotide sequence ID" value="XM_024851268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPA5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPA5"/>
    <dbReference type="GeneID" id="36558967"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452405"/>
    <dbReference type="OrthoDB" id="4436466at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="225" mass="24947" checksum="0517CB8531871346" modified="2018-02-28" version="1">MPLLRNLLLKGIPAGGVLATTSFFYSTRHIDFVPLSPSDPIFHTNYLKSYNPSDNPTIHDLHTRKVPISQIDPVLLQDKQKLLERYCGGVWAGLGFAIQRILLTCFHRTPATAQQLWLPSELLGSNFEPGTTIVDHFNVLEKSGSAILIRGGDVVSNQGLRPLDALMEVSVEVKSEDEVVEFGFKTLFFQGLGKAEGSLMPGPVVWLHEQYAKAMLESGVRYVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPE4</accession>
    <name>A0A2I2GPE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_24539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710049.1">
        <property type="nucleotide sequence ID" value="XM_024842982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPE4"/>
    <dbReference type="GeneID" id="36550681"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_24539"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="72" mass="7938" checksum="84EE317EFA28D7E1" modified="2018-02-28" version="1">MTIHSRQSGKIRQVQMICYFQDKFIGKREKIAQGEWAEAANFFGESIPVGAMDALVEANADGEPLQQAPIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ27</accession>
    <name>A0A2I2GQ27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_421613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710289.1">
        <property type="nucleotide sequence ID" value="XM_024847375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ27"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ27"/>
    <dbReference type="GeneID" id="36555074"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421613"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="201"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB54987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="402" mass="45149" checksum="12D07347576AA18F" modified="2018-02-28" version="1">MVVPPAFEKSLFPSNLGPEYVGFDHIAWYVGNAKQAATFYVARMGFKHIAYRGPETGSRAIVSYVISNGDTVFVLTSPNCAPRFEDDGRVPEEDKELLAEIHDHLTKHGDGVKDVAFRIDGDIKTVWRKAVDHGAASILPPTIMHKNGNGSITLATIGTYADTAHTLVNREGYTGPFLPGYEVITDDDPINDFLPEIDIVNIDHCVGNQPWNGVDQVVKYYEDCLDFHRYWTVDDDSMCGEYSAMRSIVVASPNEVIKMPMNEPAHGKKRSQIEEFVDYYNSAGVQHIALRTQDLVTTVSHLKQRGVSFLHIPGEYYANLRKRLSAVGLQLKEDIDLLEKLQVLVDFDEKGYLLQIFSQHVLDRPTVFIEIIQRNNFDGFGAGNFKSLFEAFESEQARRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQS9</accession>
    <name>A0A2I2GQS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_443091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710544.1">
        <property type="nucleotide sequence ID" value="XM_024850507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQS9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQS9"/>
    <dbReference type="GeneID" id="36558206"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443091"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="285"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="308"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="366" mass="40114" checksum="D9EFC7C7F7862BA4" modified="2018-02-28" version="1">MAHRGNALGKDVCCIDDLKRLGSARLSPMNRDYYNGGAMDLISLQDNEAAFDRYKLRPRVLINVEKVATETEILGTKVSLPFGFSPTASHKLAHPEGELATSRAAAKFGICMGLSSYSTYALEEVIKEGNGNPYAIQMCVLRDRSLTLQLLERAEKAGYKALFLSVDVPVLGHRLNEYRNDFRIPVDMSYPNILSSGSDRSSRTDYDPSLDWESALPWLRQHTSMKIWLKGIMSPEDVELAIRHGADGVIISNHGGRQLDGVPSTLDALRACAPAAKGKIPIAIDGGIRRGSDIFKALALGADFCFLGRIPIWGLAYNGQAGVELALQILQMELKVTMALSGCRTIEDIQKCYLSVLRPDGELAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQZ4</accession>
    <name>A0A2I2GQZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_461193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710583.1">
        <property type="nucleotide sequence ID" value="XM_024852009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQZ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQZ4"/>
    <dbReference type="GeneID" id="36559707"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461193"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30029" checksum="D8CA417698D6E4BB" modified="2018-02-28" version="1">MKGNTERDARRRAVRAVKETISHQKDLLIYEHKDLDQHAPIQVLPMPLTSDGDPKFKSEFFDPFRKPLPDPDEDIQFCPASPKEPDDAMSEGLVVGNYFKSYIWDGIYRGKADKHNNPMQPIDFPRCSLWEFEFEDSIDWRSGGIADSPDGPWIKCIFYDSVNPNDHQITRGEILCICRIMTTCLSRQAYSAHYIIPVLLLSFVGPRHARILLAHHDGTNLVIRQSDRFALWEKDIPKLKVLLRWWCSSGIGDTGTTKAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR22</accession>
    <name>A0A2I2GR22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gpi16 subunit, GPI transamidase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_452746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710629.1">
        <property type="nucleotide sequence ID" value="XM_024851299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR22"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR22"/>
    <dbReference type="GeneID" id="36558998"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452746"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014151820" evidence="2">
        <location>
            <begin position="22"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="596" mass="66153" checksum="F44CF2622A97217A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR30</accession>
    <name>A0A2I2GR30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_432879</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710639.1">
        <property type="nucleotide sequence ID" value="XM_024848358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR30"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR30"/>
    <dbReference type="GeneID" id="36556057"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432879"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.920.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="658"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB55337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1045" mass="114375" checksum="B8245744F472180D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRJ2</accession>
    <name>A0A2I2GRJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_443279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710799.1">
        <property type="nucleotide sequence ID" value="XM_024850527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRJ2"/>
    <dbReference type="GeneID" id="36558226"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443279"/>
    <dbReference type="OrthoDB" id="5343483at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="286" mass="32688" checksum="B43AE2F93A19F9D0" modified="2018-02-28" version="1">MLWNNIMQTSRELFVNPLLWTSHHMNLVGCQFVENAINPSTESIPDQEKIKIQGHQRSINTPTDAELLAIKPLATVKHRCLVDILVGQGRPFARYGKGPEFFFAGIPVHQPCYTVFHRHAQPQLHENVSSAPSLIGYIHYGHVKGDRSRIFEARPDPRGRGNRIGAEIGKNRLARVTPKQWTEDPYFICSRLLVTNMTDHECIYLYETEITAEFLRALDEPKAATDDIEWSVVRWRRLSFKPYDTFADRLAAELMAPNTGSSCCENKRLSIMIGRRELDDSVGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRM9</accession>
    <name>A0A2I2GRM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">COX15-CtaA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_346615</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710816.1">
        <property type="nucleotide sequence ID" value="XM_024843576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRM9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRM9"/>
    <dbReference type="GeneID" id="36551276"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346615"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="502" mass="55199" checksum="32CA7B80F260DA75" modified="2018-02-28" version="1">MASLGGSVPFFRSFAPRLSREFFTCRQCLTQSPNYAAKPAFRRQFAAFSFTPNTNNATSAAAFARAKKAFPSAWKRSASGSAAASAIENGAPKSRSRFPDVSHKSVAYWLLGSAASVFGIVVFGGLTRLTESGLSITEWKPVTGSLPPMNADDWESEFAKYRDSPEFQLLNPHMTLSEFKSIYYMEWIHRLWGRFVGLSFVIPAVYFVARKKVSKPMALRLAGIAGLIGFQGFIGWWMVKSGLKDDLFAPGSHPRVSQYRLTAHLGAAFVCYVAMLWNGLAILRSHRLLADPEAGTKLLDSLRDPKLNVFRRSVAGLALLVFTTVISGALVAGLDAGLIYNEFPFMGNGLAPPKSELFDQRYSRLEDKSDLWWRNMLENPSLVQLDHRILAMTTFTSIMGLWAYSKSPAMKRLLPPVAKKGVHGVVAFAFMQVGLGISTLLYLVPTPLASAHQAGSLFLLTWVLVLGSRIWHPSRTAKLLQMAAKARGQALSNAAAHGPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRP8</accession>
    <name>A0A2I2GRP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_43396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710850.1">
        <property type="nucleotide sequence ID" value="XM_024848614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRP8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRP8"/>
    <dbReference type="GeneID" id="36556313"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_43396"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="606"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="681" mass="76036" checksum="793311AB2DB66432" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRT2</accession>
    <name>A0A2I2GRT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_452914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710891.1">
        <property type="nucleotide sequence ID" value="XM_024851314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRT2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRT2"/>
    <dbReference type="GeneID" id="36559013"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452914"/>
    <dbReference type="OrthoDB" id="5377172at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014144822" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55292" checksum="E09B9B7742E27AE9" modified="2018-02-28" version="1">MARRFLATCTTLLLSLGAVADNWPFVTLATAPFVPPELHVTKSGETDPGYIFIGPRGNQDQGTAALIYSDDGHLVYQGPTEVAANFKVQKLFNEDVITFWAGNMMKLGFGYGTVHILDNTYQEIYTVRLQDNFVSPEGDHQESYIDLHESHITTRNTLLVTAYNVTQHDLTSIGGKPDDYMLDGMFYEIDIATNEIVFSWNALNHLDEIPLEKSKQGLGGDFGTHEKPWDAYHINSVNLLDDGYIISLRHYWSGIHVRNDGSVAWQLSGEKGAGDFEIDDNAIFSWQHDIRIYNQTSEGMVLNLFNNANTPTDEVAPTTGLSLGVDLVNRKVSALRVLSDDGDVIHSVSQGSFQLMSEQTNHVFLGYGSIAKVKEYDANNNQVLSAQFGEDNAVASYRGYKCQWKATPFWKPALVAQRAPDDLTRVWMSWNGATEYDNWAIYSAPSLDSDDTKFLKTVERAGFETRVDFTGLKSSFLQVVARKGDIPLGTSEIITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRZ6</accession>
    <name>A0A2I2GRZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative tyrosine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_443390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710947.1">
        <property type="nucleotide sequence ID" value="XM_024850542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRZ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRZ6"/>
    <dbReference type="GeneID" id="36558241"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443390"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="505" mass="54842" checksum="1CC83F57112D4751" modified="2018-02-28" version="1">MEFKSTQEISLEQVQRELWEIAQSPWKTGVLPNPEILSRARDSLPRSLPSDGIGFDSAQKHILDDIVPAFNGSSISPNYYGFVTGGTTPAALFADNIVSAYDQNVQVHLTEHSIATDVESSALGLLVDLFRLDRSEWHNGTFTTGATAANLLGLACGREFAVRAAASRKGVSKDSVGEWGLFEVMLASGLSGLQVLTTLPHSSIGKSAGILGFGRANVVSVCQEGSTNPLEFDLEKLERELSRPDKASIVAVSSGEVNTGRFATAGRSKMQELRNLCDKYGAWLHVDGAFGLFARVLNDSPEFASVRAGSDGLELADSITGDGHKLLNVPYDCGFFLTRHRNEAANVFTNPNAAYLTGGAGASSIPSPLNIGIENSRRFRALPVYATLLSYGAAGYRTVLEKQIRLARRLSAWLSDHTAYNILPESSSKEAQLDQTFMIVLFSAKQDDLNKNLAARINATSKMFVSGTSWQRRPACRIAISNWRADEERDFELVTSVLDEVARQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS09</accession>
    <name>A0A2I2GS09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710960.1">
        <property type="nucleotide sequence ID" value="XM_024848418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS09"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS09"/>
    <dbReference type="GeneID" id="36556117"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433167"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="513" mass="57515" checksum="E3D1423073E29AA2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSN6</accession>
    <name>A0A2I2GSN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_52163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711190.1">
        <property type="nucleotide sequence ID" value="XM_024855250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSN6"/>
    <dbReference type="GeneID" id="36562956"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_52163"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="154" mass="17139" checksum="564C8BDA09BD5739" modified="2018-02-28" version="1">MFDSKGSDSGHSALHLIRGKNNRRSAPLILNPTPSAEGKGGLKTHRRRTFHLIQSLLSGKPYGFNVAPPRHKPYCQSAEWGLGTETNEVLFYLIQQSSLSASMQNTLRMRALYRLATPLRNIQSHSIWCNTLLETGLNNLPAQVSVLDQSLLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQG7</accession>
    <name>A0A2I2FQG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_514699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000022">
        <property type="protein sequence ID" value="PLB42857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQG7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FQG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514699"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="26177" checksum="0915A7413B2CFFF5" modified="2018-02-28" version="1" fragment="single">FAPGTGPPPCLLPRAPHPPDRFASRPRPLASRDHSHPASQGTLPRQLVRQWAFVPYLAPTRQAPSTSLYSPQAPSAPTGLAVGHPRSIRPGTRPPPDRPVPFRSGAHPPPDLLPQAPCPPGGAPPSPATPAPGPHEGAWAGEGSRGKNPGCRLPRRHPQVAPRWPTGPAPGQTAKPPVRPGEWVPLRPTGSGFRQRRRTPKTPRRGSRKPEEGTVVSATRLLDRVHDPLGHFSRLQRIHPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQP3</accession>
    <name>A0A2I2FQP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_395465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395465"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="50" mass="5849" checksum="C8A512B8E284E7D9" modified="2018-02-28" version="1" fragment="single">LDCSPTNRERELGLDRRETGYTRGTVDSDNWFLRLSDQAVPRRYHLPDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQP9</accession>
    <name>A0A2I2FQP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_487025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQP9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FQP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_487025"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="74" mass="8252" checksum="F0D1C22E72A3783D" modified="2018-02-28" version="1" fragment="single">QQGYLTAYTTRLVTSVVCRGFIPARGDITIRQPAPRGFSPGAVASLLRCMARRPIRIQLRRAGQHHRVPARILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSB3</accession>
    <name>A0A2I2FSB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_459190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698798.1">
        <property type="nucleotide sequence ID" value="XM_024851848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSB3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSB3"/>
    <dbReference type="GeneID" id="36559546"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459190"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35913" checksum="00E548B6E318C2A5" modified="2018-02-28" version="1">MVGLQRLMSQFSKNSIQYDRVESEEDKEITHESTPKGKTRHEKLKQILSRVSLLWINTTLLGITGIFFFGNGQPNGKPACEVDGFIAPAMDDADVSFSTEWIDGNFLNNDPLSIFRQEPSLEVDIAWSKLADTRPIPLTREDVLAIGKDPEKSVKLGPEFGLGPDLYAGRVDVFHQLHCLDALRQEAYFEHYYHNTYPGGYNQTTQKHRAHLSHCIHIILQNILCHANTDILTHIWTDAVDHPWPDFNIPHRCRDYRALMDWQHRHAVDEGLFVKMKRPVGQEPRRTSSHFKKIVNSEMYGHLEDIMDDGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSM9</accession>
    <name>A0A2I2FSM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_58627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698934.1">
        <property type="nucleotide sequence ID" value="XM_024855284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSM9"/>
    <dbReference type="GeneID" id="36562990"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_58627"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="77" mass="8296" checksum="58C90C605FA211F3" modified="2018-02-28" version="1">MADTDEADSLTPCCLLITPAFVFGSAFCPLFRSLRSTPLSHPRFCGPEKRVRHKDPEIGELLCVATIATFLSAPGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTD2</accession>
    <name>A0A2I2FTD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 19">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_418294</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 19"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699184.1">
        <property type="nucleotide sequence ID" value="XM_024847211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTD2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTD2"/>
    <dbReference type="GeneID" id="36554910"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418294"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 19 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB43882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="44715" checksum="46C9A0F5D3C1BA21" modified="2018-02-28" version="1">MSLSNKLAITDVDLKDKRVLIRVDFNVPLDANKNITNNQRIVGALPTIKYAAENGAKAVVLMSHLGRPDGKKNDKYSLKPVVAELEKLLGKSVIFTEDCVGKEVEETVNKATGGQIVLLENLRFHAEEEGSSKDAEGKKVKADKDQVAEFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELDYFAQALEKPQRPFLAILGGAKVSDKIQLIDNLLSKVNSLIITGGMAFTFKKTLEGVKIGNSLFDEAGSKIVGDIVEKAKKNNVKIVLPVDYITADKFAADAKTGKATDAEGIPDGYMGLDVGEESVKLYEQTIAESKTILWNGPPGVFEMEPFANATKKTLNAAVSAAQSGSIVIIGGGDTATVAAKFGAEEKLSHVSTGGGASLELLEGKELPGVSALSTTGPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTU8</accession>
    <name>A0A2I2FTU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_441511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699367.1">
        <property type="nucleotide sequence ID" value="XM_024850328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTU8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTU8"/>
    <dbReference type="GeneID" id="36558027"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441511"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="311" mass="32760" checksum="640C858343F2C785" modified="2018-02-28" version="1">MSKQYLSCGSADDAHPIDIFSLAVTDTQVLSASGASALKVHSTADPEFPLVQSIDGAHKAGCHHVVTNGNGSRAVSVGFGGEIKVWDCHNGAWSQDKAVSVGSTGSAEAWAVSLSQDGQYLAGVSQDGHIKVWDLSSNGEQIRDYETKGSFGTCLDMSADGRFIASGHENGSIYIFSTETGRMPFSLSGLVKPVRAVAFSPGGKFLAAAGDSKIIVLYDTSSGEQVANFSGHSAWVLSLSWSLTGEYLLSGSFDGKVKVWSIDTRTCVATHSETEKAIWSVKWVPKIGRSEGFATSGANRSIAFYREATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUA4</accession>
    <name>A0A2I2FUA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_367566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699527.1">
        <property type="nucleotide sequence ID" value="XM_024844812.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FUA4"/>
    <dbReference type="GeneID" id="36552512"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367566"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000577">
        <property type="entry name" value="WD domain G-beta repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="8">
        <location>
            <begin position="587"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="926"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1243"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1280"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1395"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="926"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="971"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1203"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1323"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1424"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1603" mass="175530" checksum="F6E655D1E1B5DF50" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV82</accession>
    <name>A0A2I2FV82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_288245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699852.1">
        <property type="nucleotide sequence ID" value="XM_024843222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV82"/>
    <dbReference type="GeneID" id="36550921"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_288245"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="129" mass="13910" checksum="D3DFED297152FE02" modified="2018-02-28" version="1">MSKDASINSVKLPSPRYVCPIESSTRSPANTSPIQGWDPSFARYSLRLESTSIDPCPTATFTFTVTELMTNFGGVLHGGCAATIIDMLTTVPLGAISRPGFYTSLGVSRSLNVTYFRALRKGEDARRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVG2</accession>
    <name>A0A2I2FVG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_288271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699858.1">
        <property type="nucleotide sequence ID" value="XM_024843223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVG2"/>
    <dbReference type="GeneID" id="36550922"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_288271"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="192" mass="21062" checksum="7694C44967B5E539" modified="2018-02-28" version="1">MAALGISVLTSPSSESSKTTGYEGLSGYHLNAPNPPPALVSKAQPTESPLHPSADTSTDPTREISSPRPQLFPPGQSPIPVKRTISEDCTQSGPSDRTRKYHCLRKDAERQERPHRYLLEKPCLPARMLRGHPAPRQILSPQSRIPGFRLSNPSMGNGVAKRPSREKGPRRVAPPMYKLPEFTGPMRSKMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVZ1</accession>
    <name>A0A2I2FVZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_479333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700086.1">
        <property type="nucleotide sequence ID" value="XM_024853661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVZ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVZ1"/>
    <dbReference type="GeneID" id="36561359"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479333"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB44784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="332" mass="39123" checksum="5A264B06932B5D04" modified="2018-02-28" version="1">MARVYADVNEHMPRSYWDYDSVNISWGVLENYEVVRKIGRGKYSEVFEGINVVNYQKCVIKVLKPVKKKKIKREIKILQNLAGGPNVVALLDVVRDSQSKTPSLVFEYVNNTDFRTLYPRFSDYDVRFYVYELLKALDFCHSKGIMHRDVKPHNVMIDHEKRKLRLIDWGLAEFYHKGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGAMFASMIFRKEPFFHGNSNSDQLVKIAKVLGTEELFEYLDKYEIELDPQYDEILSRFPRKAWHSFVNADNQRFVSEEAIDFLDKLLRYDHAERLTAQEAMAHPYFAPIRSAETQARNNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWB7</accession>
    <name>A0A2I2FWB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_513047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700233.1">
        <property type="nucleotide sequence ID" value="XM_024855054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWB7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWB7"/>
    <dbReference type="GeneID" id="36562760"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513047"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="313" mass="33444" checksum="852DC4F5366EF17C" modified="2018-02-28" version="1">MASNARYYASPAEATKFATHLLAKSGLSEEDAKSMAECLVLADVRGVDTHGLARLPQYLERVSKGRVNATPRIQITEKTPVVAHLDGDNGFGFVVATKAMTEAIKRAEIYGIGMVTVNHSNHFGMAATYVLQALEANMISLVFTNSAKQMPPFGGKEALLDADGNPTTDVEVALNGSMAPIGGPKGSGIAILMDVMSGVLTGAAFGGEVGDQYKDTKPQNVGHCFVVLRPDVFMSTEDFKARMDVLVQRVHGVSPAPGFSEVLFPGEPEYRLSLQRQKEGIPYADAEKAMFANSAKKYGIDELLLSDTPLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWD6</accession>
    <name>A0A2I2FWD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_366681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700236.1">
        <property type="nucleotide sequence ID" value="XM_024844768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWD6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWD6"/>
    <dbReference type="GeneID" id="36552468"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366681"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="199"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="356" mass="40699" checksum="FE09C4BBA0205537" modified="2018-02-28" version="1">MTITAPNDTLYPPKPIPQGAWDTHHHIFEPDIFPFAAGRHFTPARASLSDLQSFERGLGVQNVCIAHGLSYGPDCSSLLYYLGQFNAPANANAPDQETSQGECQARGICVLDISTVTDEVLDAYHAAGVRSVRIDFFRENAMHDVDAQKRLIENTATRLNTWWQSRVRKRRGQDQDQDQDRGKWSIQIQQPHLEHWVVLRATIAACPVPVVVDHFALVAGSSHRAGDRTTCIQDSGYLRDEEREGLFALRDLLREGNLWIKLSAPYRCSNLAPGYEDLKWLVRLLVDANPERVLWGSDWPHTQRHEDRAGKSTSQEEAFLQVNDKRWVEGLSRWMSQREWQLMWVENPRVLYCNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWU2</accession>
    <name>A0A2I2FWU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">P170DRAFT_440229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWU2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440229"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000005">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="339"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="797"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="956"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1042" mass="118476" checksum="D62B1CBF09295852" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXA6</accession>
    <name>A0A2I2FXA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-dependent Clp-type protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_513291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700566.1">
        <property type="nucleotide sequence ID" value="XM_024855092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXA6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXA6"/>
    <dbReference type="GeneID" id="36562798"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513291"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000138">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="183"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="461"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="615" mass="67451" checksum="6FA5B12EE8797FD3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXD8</accession>
    <name>A0A2I2FXD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_278881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700602.1">
        <property type="nucleotide sequence ID" value="XM_024843180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXD8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXD8"/>
    <dbReference type="GeneID" id="36550879"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_278881"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="445" mass="50315" checksum="2A14FAEFF1019476" modified="2018-02-28" version="1">MAIPMTQDPGRGHVDLYGNVFEVPTFTMKQIHDAIPAHCFRPSIARSMGYVVRDYVLLGSLAWGVYVCTPLLPSLYLRGVVYGLYTVAAGMVMTGIWILAHECGHGAFSRSKTLNNAVGFLLHSSLLVPYYSWKISHSRHHKATGNLQRDTVYVPHSREYWTRTAMGSDVDPHSIGAAELTEDVPLVTLWHCLLFQLFGWPLYMLDNLSGQKGASGFPQHSHYWFGADSALYTESQLHSIFLSDIGVLMMSVVLFYAVRLFDLWTVCVFYGIPYLWLNQWIVTITYLQHTDGTLPHFAHSQWSFARGAAATIDRSFTLGGFDVDKHLFHGIVGTHVLHHLVSTVPFYHAYEATDAVKRVMGKHYRADQTTPLMTALFRNLRDCQFVEESSGMDGSGVYMFRNLHGRGMRPRNLVAGESMSSWEGHLPPPSKEASRDWRHLVAWIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXS6</accession>
    <name>A0A2I2FXS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P170DRAFT_449093</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YME2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700688.1">
        <property type="nucleotide sequence ID" value="XM_024851016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FXS6"/>
    <dbReference type="GeneID" id="36558715"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449093"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000959">
        <property type="entry name" value="Mitochondrial escape protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="22">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="1318"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB45386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1375" mass="154000" checksum="01A5A62D93266AB3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXT5</accession>
    <name>A0A2I2FXT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_244236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700751.1">
        <property type="nucleotide sequence ID" value="XM_024842970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXT5"/>
    <dbReference type="GeneID" id="36550669"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_244236"/>
    <dbReference type="OrthoDB" id="9981319at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="143" mass="15944" checksum="6FA68F2BC7B5A5FB" modified="2018-02-28" version="1">MPLYTIEHAIPLDKSQRDALAQTLTHIHTRKFTTPSLFVNVQFVDSTRQCNYIAGKERRINRILAHVRAGGTRTTADFQDLAQKIEDAWNGIVNGGQRGSKETELNRVFVLGAITAGLENGILLPTVCLPLFCPYLSLCFTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXY6</accession>
    <name>A0A2I2FXY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_413754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700796.1">
        <property type="nucleotide sequence ID" value="XM_024846989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXY6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXY6"/>
    <dbReference type="GeneID" id="36554688"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413754"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000009">
        <property type="entry name" value="Hydrophobic dipeptide epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF3">
        <property type="entry name" value="ENOLASE SUPERFAMILY MEMBER DDB_G0284701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00180">
        <property type="entry name" value="muconate_cycloisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="369" mass="39446" checksum="D6DB2D1A67A6A668" modified="2018-02-28" version="1">MHISDITVFSYDANYRYGTYSMSHGRSTKGQKSIVVRILSDDGIEGWAETAPLGSDYLPSSFTGELAALKELGPQVLGLDPRSPAAIDEVMDRTMMGAMAAKAVIDMACWDILGKSMGLPTAILFGGFLTERPRAFSVIGIRDAEAAVSQVQGERNKGVTAMQLKVGDDPLADAQRVKSIHDALTDNVHIWADANGGWTLGQALTFARAVGQDITVGLEQPCRTLSDCAEIGRRTGLPIILDESVVTMTDLFAAHAAGITGINIKPSRVGGLTKARMLRDAAAALDMVINCDDTWGSALTTAQNVLLATTTPSHRLCAVDLFAEWTEPLIADIPRMDSNGRVTANTHPGNGYCAIQVEHLAEPLFQITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYU1</accession>
    <name>A0A2I2FYU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_414366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701113.1">
        <property type="nucleotide sequence ID" value="XM_024847014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYU1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYU1"/>
    <dbReference type="GeneID" id="36554713"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414366"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000637">
        <property type="entry name" value="Uncharacterized oxidoreductase C736.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38110" checksum="207511975CE97C71" modified="2018-02-28" version="1">MVNFKTVQAHNASLKLLGPGLVGVFVGGTSGISLSTALAFARYTLSPKIYLIGRNQSAADHAIASIRTLNPSAQATFLQSDISLLKNVDRVCEQITASERKVNLLFMTPGYITLQGRNETTEGLDRKFALHYYARMRFVNRLMPLLTAAADSPVETATANARISRVVSVLDPHVAVRLCGSGALDYSDLSLKHSFTLSRCGAHASLMGDFFLEGMAKRYVGTSFVHAYPSGVDTGLMREIPAGEVLATVLRPFLSPFLVPIEESGERHLFAATSGRYPPKARGEIVEPGGDMASGSDGLRGSGCYWVSWDGEVFPQNSKLDRMREQGAVEKVVQHTEEVFKRVCEEGGTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYX0</accession>
    <name>A0A2I2FYX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_414407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701134.1">
        <property type="nucleotide sequence ID" value="XM_024847016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYX0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYX0"/>
    <dbReference type="GeneID" id="36554715"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414407"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="247" mass="27105" checksum="35AA1EE92E6A098C" modified="2018-02-28" version="1">MTCEACRTIPPVISQGYEPKGEYKSIGGLNTYTTGPHTSTTAIIDIYDIFGISSQTIQGADLLAARLNTLVLVPDFFKGKGAQHDWIPMDTPEKEKALMGFFMEYAQFEPNVGVLKAAVEEFKAAFPTVGKWGVFGLCWGGKVTALSSGEGTPFVASGQVHPGRMDKADAEKITIPHIVLASKDEPADVVQQYKDIIANGPGSHVETYESMWHGWMGARADLDGEESVKEYRRGYEQLASFFEQHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYX5</accession>
    <name>A0A2I2FYX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative small nucleolar ribonucleo protein complex subunit Utp15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_439544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701143.1">
        <property type="nucleotide sequence ID" value="XM_024849865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYX5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYX5"/>
    <dbReference type="GeneID" id="36557564"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439544"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000633">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000867">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="392"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="540" mass="59772" checksum="BA5886B4EF88B98E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ25</accession>
    <name>A0A2I2FZ25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_254680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701192.1">
        <property type="nucleotide sequence ID" value="XM_024843044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ25"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ25"/>
    <dbReference type="GeneID" id="36550743"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_254680"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="103"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="265" mass="29501" checksum="924790AAA4F0C6CC" modified="2018-02-28" version="1">MPHSSRKKTPHHQHKRLQVTDDSGWTHVSTSGKTARQVLRTTAAHQQDDPAQPGSFVPAEAPSKLTAEDLGRQFESYRRRWETSDACQVVREALRAHTTPAAVAAQDAIVCIGLGSPSGFLRGGWVDRRSVSMYQLAGLVSVVDWMKQTNPNVSVYAQDPVFNELDKSLLSSLGVVVLEHPHAFEKVTPATFLYCPGAEQAHLSQLLALNPGFLFGGPLEDNDSEVVRQFVGARGSVRLPRFQEHEHAFWNMRIYYPEDTEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ27</accession>
    <name>A0A2I2FZ27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_254212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701177.1">
        <property type="nucleotide sequence ID" value="XM_024843039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ27"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ27"/>
    <dbReference type="GeneID" id="36550738"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_254212"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="237" mass="26626" checksum="65E344228DCADBF8" modified="2018-02-28" version="1">MSSPNIDLYTAGTANGFKVSILLEELGLPYKTHALDLGANQQKEEWFLKINPNGRIPAITDGETRVFESAAILLYLADKYDTERKFSYAPGTAEYAEQLSWLMWQMGGLGPMQGQANHFAAFATVRSDYGIQRYTDETKRLYSVLELRLQESPYLAGDKLTIADLASYPWVMAGPLVLDLDLAEWPALKKWSDSIAEREAVQKGLKIPPPRVPLDQMAEFLAGKKREILARENTDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZE7</accession>
    <name>A0A2I2FZE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_439693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701307.1">
        <property type="nucleotide sequence ID" value="XM_024849898.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FZE7"/>
    <dbReference type="GeneID" id="36557597"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439693"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1742"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1142"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1296"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1142"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1175"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1300"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1316"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1925" mass="213577" checksum="917ADA2FC8F234C5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Q8</accession>
    <name>A0A2I2G0Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_438222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701728.1">
        <property type="nucleotide sequence ID" value="XM_024849544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Q8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0Q8"/>
    <dbReference type="GeneID" id="36557243"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438222"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="143" mass="16305" checksum="D9A881653FDF8927" modified="2018-02-28" version="1">MSVAATAKRPEIIEIARGLNHVPMSEEFEKMISGMMYNPIVPQLLEARHRARGVTQDYNNLDAKTVSYDKIFDVRMELLKKVVGKVGSGTFVEPPFLPDYGCNISIGKDCFINFKFHRPGHQSDSHRRPRAVRSQRQHLHGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G107</accession>
    <name>A0A2I2G107_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_438301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701853.1">
        <property type="nucleotide sequence ID" value="XM_024849569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G107"/>
    <dbReference type="STRING" id="1392250.A0A2I2G107"/>
    <dbReference type="GeneID" id="36557268"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438301"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB46551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="414" mass="46262" checksum="EBD27052988A592D" modified="2018-02-28" version="1">MTTRYRVEYALKSHRRDQLIEWIKGLLAVPFVLHSQPTVIYQEDSENLVAVAADTHQRYAEIFRDVESLIRDHIDHEAKDLPGKSKLKLLVPTVGSFFTPLHLEDAFKYQDRIRAISRRRFVAPSFNDIRLILNSAQLLGLVRSSHVDLVTFDGDVTLYDDGACLTSDNPSIPRLLRLLRQDRKVGIVTAAGYTEAEKYYARLKGLLDAVHESSDLTPAQRDGLVVMGGESNFLFRYDAASPSRLSYVPRDQWLLPEMTTWQESDITALLDLAESSLRACVRNLGLPVTVLRKDRAVGVSPVNGTRVNREQLEETVLVVQNTIERSAVGGILPFCAFNGGNDVFVDIGDKSWGVRACQQYFGGIERTRTLHVGDQFLSAGANDFKARLASTTAWIAGPAETVQLLDELSSVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1Q3</accession>
    <name>A0A2I2G1Q3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_466207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702109.1">
        <property type="nucleotide sequence ID" value="XM_024852397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1Q3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1Q3"/>
    <dbReference type="GeneID" id="36560095"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466207"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27407" checksum="C60A028A3C670544" modified="2018-02-28" version="1">MVSTRHHPRDFPPPSTARASSPPSSPSASANGNGKKWVHTPSAAVTLWLLVSVPLVIWDAGYVLLRPHSMPGNKLHSPIWTPYALYGTIDYIYGWPAFNARNGFTAAQSVLNVLETIGYIYYLVTVYRHGSSATASGRASQRKTKKGLLWLFKDEKVLPGRTGANALLVAYSASVMTLGKTLLYWLNEFFSGFENIGHNDAVTLIFLWIIPNGLWIVFPAYNLHVLGEEIVSSLDGLAPRQRPGRPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1W2</accession>
    <name>A0A2I2G1W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">P170DRAFT_438563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1W2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438563"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="158"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="449" mass="50705" checksum="0A494DAD7428F66C" modified="2018-02-28" version="1">MGIQRRGVYNEDDKPVGGKMMGRGWIVPTLGVRGLVFHVWRFRRRPSADHLLGTFHLLRRIPPEQPAHRREILPLYSVCTDSAMVRHKKDNFSRGGKKFANPRPRPVPRGDGEAADRPAFKAACWDLGHCDPKRCSGKRLMQFGLMRELSIGQKFPGVIVSPNAKKILSPADRELLEQFGAAVVECSWVRVKEVPWSRIGGRCERLLPYLIAANTVNYGKPWRLNCVEALAACFCICGHEDWAREVLKHFPYGEAFLEINSKLFKRYAACQTEEDIKRTEEEWLAKIEKEYEDSRAEGGADDMWTVGNTNRKAGVDSDSEEDDDEKSDKDDEEEEEADKDPFAISDDSEEEEQMAEIRRKILSSKSFQNPSVSDKPQPEKIAQPDPEPVEDSDAESGSAEGSDDEAFDNIINATPVTDRTGIIAASQKKKKETYSASFSRTTINAPKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1Z6</accession>
    <name>A0A2I2G1Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_511560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702196.1">
        <property type="nucleotide sequence ID" value="XM_024854901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1Z6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1Z6"/>
    <dbReference type="GeneID" id="36562607"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511560"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016477885" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="332" mass="38694" checksum="4AAF76AC6E0FCB2C" modified="2018-02-28" version="1">MILGSIRGKSGYSLLFLLVAIFVGRTAASLGDHLPDFKECVKICQTENCEEGNSALPLHLRLMLWTCPAECDYTCQHVVTDRRVARDPPMLNPVVQFHGKWPFRRILGMQEPFSVLFSFLNFVAHWHGMARIREVIPSWHSLRSYYLAFGYCGLLCWTFSTLFHTRDFPLTEKLDYFGAGGNVMYGFYLAIIRIFRLDQAEPRHKPTLRRLLTAVCLFLYTLHVCYLSFWSWDYTYNMIANIVVGMTQNVLWTAWSIYRYRKTDKIWTVWPALIVVWIILAMSLELLDFAPWESLIDAHSLWHLGTVIPTAWWYLFLIKDVQDDVAGDRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G294</accession>
    <name>A0A2I2G294_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RhoGAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_388072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702293.1">
        <property type="nucleotide sequence ID" value="XM_024845828.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G294"/>
    <dbReference type="GeneID" id="36553527"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_388072"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000452">
        <property type="entry name" value="Rho GTPase activator (Bem3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000066">
        <property type="entry name" value="Rho GTPase activator (Bem3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="675"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1286" mass="139678" checksum="91A8CD3D4D80F7A8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G348</accession>
    <name>A0A2I2G348_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_511928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702603.1">
        <property type="nucleotide sequence ID" value="XM_024854938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G348"/>
    <dbReference type="STRING" id="1392250.A0A2I2G348"/>
    <dbReference type="GeneID" id="36562644"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511928"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="204" mass="22395" checksum="D20B4087B07FB39E" modified="2018-02-28" version="1">MEKRFVLETIQRDSSSFLNCLNAIAASLAALQTLVDRDNREPTDHSDYEAELSIILSKTGRDIPESEAMSYVLGYTCSHDVSARTQQFKNSQWCFSKGLDGSCPLDPVLVSPSAIGDPHSLRIRAIHNGHVVQASNTREMIFGIAKTISFLSQGTTLKRGTVIMTGTGPGIGAMLTPKVVLQDDDDMRVEVENIGTLVNRVYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3A7</accession>
    <name>A0A2I2G3A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_388869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702666.1">
        <property type="nucleotide sequence ID" value="XM_024845853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3A7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3A7"/>
    <dbReference type="GeneID" id="36553552"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_388869"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000113">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF85">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="516" mass="59125" checksum="4D63A9ACFDA7E3FA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3L0</accession>
    <name>A0A2I2G3L0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative fumarylacetoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_437319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702763.1">
        <property type="nucleotide sequence ID" value="XM_024849339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3L0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3L0"/>
    <dbReference type="GeneID" id="36557038"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437319"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="4">
        <location>
            <begin position="80"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="343"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="589" mass="63735" checksum="4E2EB25FFE8BC72B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3Q4</accession>
    <name>A0A2I2G3Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_193637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702802.1">
        <property type="nucleotide sequence ID" value="XM_024842718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3Q4"/>
    <dbReference type="GeneID" id="36550416"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_193637"/>
    <dbReference type="OrthoDB" id="4416590at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014129634" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16253" checksum="8C38658D7971F655" modified="2018-02-28" version="1">MKFSALALLLAAGSAIAAPTTAAKRASALKITDFWANASRASGTTNMHMVLTDPNYPDDTPTDCNVIWGFGKSPDENARCIGGNYYIRFPDGGADISQWSIELERVDGPIPVKARFALNDEVEGSKWKCGPTENPGVTERCNYEGVLEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3Z1</accession>
    <name>A0A2I2G3Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_437405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702881.1">
        <property type="nucleotide sequence ID" value="XM_024849357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3Z1"/>
    <dbReference type="GeneID" id="36557056"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437405"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="308" mass="33175" checksum="3AA2AD0321AA322B" modified="2018-02-28" version="1">MAAPTKVTFPSFMLQVCGELYAPVPGSPDRKGAAVVVSHPMTGVKEQTSADHARLLSKAGFYALTFDAAYQGESTGQPRGLEDPHQRVEDNKAAVSFLTTLQGKVDPSRIGVLGICASGGYTSYAAQSDSRIKALATVSAACVGRMTRNGGLHKENNKEVPEAIAGALQAAGQWRTQEARGPHSEAPAMFSSDIKEIPDNADSFFKDAAAYYGSKRGNHPRSDQKVPPSSYDLMISYDSFNFQHLISPRPLLMIAGSEAQTLHYSETTVAAAREPKELFIVDGKNHFELYDNLTVSGPKLVEFFGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G400</accession>
    <name>A0A2I2G400_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_476292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702912.1">
        <property type="nucleotide sequence ID" value="XM_024853334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G400"/>
    <dbReference type="STRING" id="1392250.A0A2I2G400"/>
    <dbReference type="GeneID" id="36561032"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476292"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="268" mass="30826" checksum="781C2ADB1517191B" modified="2018-02-28" version="1">MPETMDHSRLRESLLTLQRCIESTRWRFPIPYAETRELGQFQIHISYLSLDGGNSLKPRFFAPLPSACPLLQALTPEFIACEYDTDFPNLPEPIRTEAMCDHVKAALDAIIPQALSHGQYPWTTLEATDERFSQLPHQQGRFGPYWITYHQHSSRPHIKCIMSNNQRVQNDRVSSNEVLMAINLMLMQMHDPRFNNHMIVPVLLIVMEDSHARVIEAYFDGKTLTVRKTIEQLYREGSPTFIRTMARVFLAEPLGNTSQAAFDRLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G493</accession>
    <name>A0A2I2G493_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_437450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702993.1">
        <property type="nucleotide sequence ID" value="XM_024849368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G493"/>
    <dbReference type="STRING" id="1392250.A0A2I2G493"/>
    <dbReference type="GeneID" id="36557067"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437450"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB47691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="492" mass="55666" checksum="F7D2C30B59D20978" modified="2018-02-28" version="1">MSHSIMWKQPKYRSRKRFLPLVLVVILLLNIYFLWFSPIAHTPLPIRQGKLWRNLHALLEKHAPQCSSPDLRGASAGTPRFDANDESSRRNYIVNSDDIQQPLQIAHDGFVHDMQELKSDRAYNPRTKGIVSAAGGTYLPTFLVTLRVLRRTESKLPVELFVKDYAEYEPYICEIVLPQLNAKCIVLSDVLSTLDGSRSEYPIEHFQIKSFAILFSSFEKLIWMDADILPLHDPAKLLNSEPFSSAGLVTWPDFWSNTASPLYFNVSRQPDLPLNARQATEAGVFLVSKKTHYMTLLLSAYYNYHGPSYYYPLLDQGAPGEGDKDTFIQAATALGEKFYTVSEPVVDLGHPDRWNQGIIGAAMLQADPMEDYALTRRGKWRVKDPEVAKAARGFFIHSYSPEFNAGGDLLGEKSRSKDGNPTRLWTDSKEALERFGYDAEKVVWEEAKTVSCTLEHAFDAWKSKSGLCEGVQKHWDAVFEDASAELPKFTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G534</accession>
    <name>A0A2I2G534_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_497028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703294.1">
        <property type="nucleotide sequence ID" value="XM_024854103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G534"/>
    <dbReference type="STRING" id="1392250.A0A2I2G534"/>
    <dbReference type="GeneID" id="36561808"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_497028"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="277" mass="30015" checksum="AE27A109005049DC" modified="2018-02-28" version="1">MSPNHTPKLPLNEHISIVTGCSSGLGKALTSSIHAAGHRIVATARNADSLSYLPDGPNILKLSLDVTSREAITQSLSAAVDKFGRIDVVINNAGYALIGDTEAIPESDARLQMETLFWGPVFLTQEAVGIMRDRNPRGHGGTIVQISSIGGMLTFPGSAFYHASKHALNGFTDSFAKEMNPDWNIKFLVVAPGGIRTNFDSSMQLAARHPAYDTPEGSLNQLVAYIGNKEFRKSWSDPELCARVLFEVVVGQKERSPPRRLLMGEGAIELLVGRDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5D9</accession>
    <name>A0A2I2G5D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_361226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703392.1">
        <property type="nucleotide sequence ID" value="XM_024844458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5D9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5D9"/>
    <dbReference type="GeneID" id="36552158"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361226"/>
    <dbReference type="OrthoDB" id="5431097at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="453" mass="50514" checksum="B5A87B00A6189B29" modified="2018-02-28" version="1">MTVAAPPVAPVHENGLNGVPHGHHVNMGLPRFHPIAMNPSQIAHHEHMMQNHHHFRPFQPPPMQEPGPPVPPPPHHPANIDHIESRLRQLEHEEAARMAARSHLLAVRKREDEDYRRMTENAEAEEEDLRRQRKRLKRESMGLGFNAGMDSPPLRPTPPRRLSETNAATTLAFFKQQSPPEPRPIPPPPVQAPPPHPPPQHIPHDPTGATSIRRKQKYTIKNVEAWGERHGRPAAHDPSGRALWKRPSDGSLVYLTCPVSGCGKSDFVTLHGFMCHLTKKHKDRSLGSQSRALEVCGIVYDPNAPLPPMSTVNRASTEESRLESAPTDPEGYQQEVEYSSASDDEETGEKPCPVKTESSDRALPTPAASLPAEEDRPKASNPGTSTKQSISSIIDRDPEDDPRERLNSIPRPHETVSRASPEPRRPALDEAEMPRPRDLEIERSVLKETAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5S7</accession>
    <name>A0A2I2G5S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Velvet complex subunit laeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_497374</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703495.1">
        <property type="nucleotide sequence ID" value="XM_024854108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5S7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5S7"/>
    <dbReference type="GeneID" id="36561813"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_497374"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="312" mass="36437" checksum="8FDB9F0FC93C1622" modified="2018-02-28" version="1">MSIETITCRESTTKSACRDDRPTHRERFFLLSCDEREQDRLNFLHKVFSIARRSDDLIHVPHLVKGRVLDLGCGTGIWAIDVAERYPEMFVVGVDLSPTQPDRHPPNCEFYAPFDFERQWEMGEDSWDVMHLRMGWGSVSNWPSLYRRIFAHLRPGGWFEQVEIDFEPRILTSSSEHLPLGQWYQAFEYATAQTMRPLTHNPPETFGFLQTAGFAEICHQTIQLPLNQWPPDPHQREIGRWYGRAFLQLIEAIDLGSLNRTHGLITQAKLEASDRSIHTFHVLHVYRAQKPPSARSCSSYKCRRHEQTYVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6P2</accession>
    <name>A0A2I2G6P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_438119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703842.1">
        <property type="nucleotide sequence ID" value="XM_024849514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6P2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6P2"/>
    <dbReference type="GeneID" id="36557213"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438119"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013988861" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="42"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="563" mass="61426" checksum="DFB12F756E2EAA5E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6P9</accession>
    <name>A0A2I2G6P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_465858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703850.1">
        <property type="nucleotide sequence ID" value="XM_024852362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6P9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6P9"/>
    <dbReference type="GeneID" id="36560060"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465858"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000228">
        <property type="entry name" value="FAD-containing monooxygenase EthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="486" mass="55084" checksum="93B991EA43C7DCDD" modified="2018-02-28" version="1">MEDFDVIIVGAGISGINAAYRLQSQHPNLRYAILEARNNLGGTWDLFRYPGIRSDSDLFTFGFEWHPWDQGCPIADGRLLKQYLHNAAEKHGIDKKIRFQHQLLGADWSSADQNWSLSVDHDGHTQSLTTRFLVLGTGYYDYHRPLEADIPNLDSFQGQTIHPQFWPEDLDYTDKKVVIIGSGATAITLLPNMAKKAAHVTMLQRSPTYILSLPNRKHPLLSYFLPTNFFRRLQRINWMITSRLFFLFCQALPSVARWILRRNVTRQLPAHVPFDPHFRPRYNPWDQRLCVSPDGDFFQSLHTGRADVKTDTIRQVTPTGIELNSGETLDADIIVTATGLRLQIAGGASLTVDGVPQHIPEKYLWRGMMLQDVPNTVCIIGYTNASWTLGADATAHFVTRLLRELDERGAKAAVPRLDAAQRASMQPRRLLNLKSTYVTTAEESLPKTADRGPWVPRDNYLDDISFAQKGRIDEGMEFTGETKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G711</accession>
    <name>A0A2I2G711_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_455598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703966.1">
        <property type="nucleotide sequence ID" value="XM_024851546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G711"/>
    <dbReference type="STRING" id="1392250.A0A2I2G711"/>
    <dbReference type="GeneID" id="36559245"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455598"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="268" mass="30774" checksum="80268C332F3FB6B6" modified="2018-02-28" version="1">MDTSIRSTIHTEAVAPIITEWILPTKTKTDLGKLFGELGRGVVRISRTRLIKGPCRESELAALKYVAEHTSIPVPKVYKTHYYQDALYIEMEYIRGSTLQSAWFRGHPKESEPPREEIVASAALKGGLDLRIGPRPFGPFDTHQDFHAYVRGNLAIEHCTQTFGEEVTKCHTHKYRSCFTHADLCLRNIMVDNGKVTAIVDWGFGGWYPEYWEYTKAHYGQIDLPEWYEGLESALDRYDDELLAEQVLWEQCDEPGFIWEKADMQNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G729</accession>
    <name>A0A2I2G729_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="12">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_356702</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703986.1">
        <property type="nucleotide sequence ID" value="XM_024844169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G729"/>
    <dbReference type="STRING" id="1392250.A0A2I2G729"/>
    <dbReference type="GeneID" id="36551869"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356702"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014131048" description="Alpha-L-arabinofuranosidase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB48684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="328" mass="35971" checksum="11A82CC67EA90F4D" modified="2018-02-28" version="1">MRPQYTSPSFAPVGILLLTSLPSILAQCELPSTYSWTSTDVLAEPKSGWASLKDFTSVVFNDKNLVYATFHDTGSTWGSMNFSPFSDWSDMSSATQNAMTEGTVAPTLFYFEPKDTWILAYQWGPTAFSYRTSSDPTDANGWSSAQPLFSGTITDSSTGPIDQTLIGDDTNMYLFFAGDNGKIYRASMTIADFPGDFGTDSEIIMSDTTDNLFEAVQVYTVQGQKQYLMIVEAIGANGRYFRSFTADSLDGSWTPQAATESQPFAGKANSGATWTNDISHGDLVRSNPDQTMTVDPCNLQLLYQGRDPNSNADYNLLPYRPGVLTLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G789</accession>
    <name>A0A2I2G789_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_316769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704042.1">
        <property type="nucleotide sequence ID" value="XM_024843287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G789"/>
    <dbReference type="STRING" id="1392250.A0A2I2G789"/>
    <dbReference type="GeneID" id="36550987"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_316769"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="87" mass="9549" checksum="F8F79E86E25F4912" modified="2018-02-28" version="1" fragment="single">NTPLHIACIQGNSDVFDELTTKSSVDIELINEKGEKPIHLAAQNGNVHIVMQLLGMGASKNVRNDEQFDPLHLAVRGGHLDLVRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8D8</accession>
    <name>A0A2I2G8D8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xenobiotic compound monooxygenase, DszA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_455882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704452.1">
        <property type="nucleotide sequence ID" value="XM_024851576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8D8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8D8"/>
    <dbReference type="GeneID" id="36559275"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455882"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="37"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="536" mass="59206" checksum="583B2B838BAB5C25" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G924</accession>
    <name>A0A2I2G924_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_436962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704684.1">
        <property type="nucleotide sequence ID" value="XM_024849261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G924"/>
    <dbReference type="STRING" id="1392250.A0A2I2G924"/>
    <dbReference type="GeneID" id="36556960"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436962"/>
    <dbReference type="OrthoDB" id="4167490at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="439" mass="49109" checksum="1F7370CEA6AA91C1" modified="2018-02-28" version="1">MSIEQKLTSSQSQSNKRARLLIVKPSKPRPKRSRLEALPVELIEKIFLYSLNANLPRASPSLAAAVSSERIYRALVLLAFWNDTSSSPPNTSGTTIAKILRPLDYVPLDYDERKALQISIMRCKWCTVDRLLSQLPNLMNLTIQRHWVNAGMRMTADQEAGLARFLSRQEDLRTFEGTGTDNAHYTLSITPLVSIRITCHETDQQQTHQILGILDFPQKLLSGGGQSSHDDEPALFTRDHVACLEILRVTSGFARPDLIHTGIRVSREATQAGIHAALVENNERALATLLKIDEYVFRSENTSVVQAGPDNDTPPYTLPAEHYRTAVRVARHDPSFFQLLLRASTESIPADDSEITEWAMGMNDSFGHWLLDLMLHLPQRVEAARANPAEGAVFYLGRANGQVDLARRYLRDVLGVEELGSWMEESEVDVEGLWTDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9A6</accession>
    <name>A0A2I2G9A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_184391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704750.1">
        <property type="nucleotide sequence ID" value="XM_024842683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9A6"/>
    <dbReference type="GeneID" id="36550381"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_184391"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="81" mass="9312" checksum="E8E9929F8A09DD10" modified="2018-02-28" version="1">MFRPTGLGLMRILLSVFFIACCLWEDFCPPGFQVLFSFVILPLSSALVLPVLLLLRIFLFCLYQWARAEVPWHSISSFAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9L0</accession>
    <name>A0A2I2G9L0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_384621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704863.1">
        <property type="nucleotide sequence ID" value="XM_024845684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9L0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9L0"/>
    <dbReference type="GeneID" id="36553383"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384621"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34303" checksum="625BF744E0686E07" modified="2018-02-28" version="1">MASRNQDGFREPPPSYHASNPSDDTNPPPYHNWQEAVPDTTTFPPPPITGYYCSGTGNASSNDAKRAHEFCDGTPLYTPVKPSNAVYNSVQVHDVRPVQPQEFSGSIRLLSPGRWKVATEDGNRDCSIWTNLPLFFSKADSPWLTNRSKTIYFEAKLVGLRRGPVADSSGFSIGFLAQPYPSWRSPGWERGSLGVFSDDGCRFVNDSWGGKDFTAGFRAGETVGLGMTFQLPGKSERIAQGEKKSLMTEVFFTRGGRRVGGWDLHEEQDEEAGGVKGLEGDFDLYGAVGFFGGVDVEVNFNRSHWLWNPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Z0</accession>
    <name>A0A2I2G9Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_384903</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704999.1">
        <property type="nucleotide sequence ID" value="XM_024845697.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G9Z0"/>
    <dbReference type="GeneID" id="36553396"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384903"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001601">
        <property type="entry name" value="ABC multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1115"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1148"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1192"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1230"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1263"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1384"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="85"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="779"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB49697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1420" mass="157906" checksum="E66F474BAFFA0DE8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAW3</accession>
    <name>A0A2I2GAW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_380337</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705325.1">
        <property type="nucleotide sequence ID" value="XM_024845522.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GAW3"/>
    <dbReference type="GeneID" id="36553221"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_380337"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="955"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2452"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="955"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="2532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2532" mass="275217" checksum="2CEEBB7B3BAEBDAB" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBB8</accession>
    <name>A0A2I2GBB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_405001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705480.1">
        <property type="nucleotide sequence ID" value="XM_024846563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBB8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBB8"/>
    <dbReference type="GeneID" id="36554262"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405001"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="142"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="464"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB50178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="724" mass="79964" checksum="830D0E99FF5498AE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBC4</accession>
    <name>A0A2I2GBC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_435363</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705476.1">
        <property type="nucleotide sequence ID" value="XM_024848920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBC4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBC4"/>
    <dbReference type="GeneID" id="36556619"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435363"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="72"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="589"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB50174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="785" mass="85183" checksum="76136EE0D8D66D76" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC15</accession>
    <name>A0A2I2GC15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="11">DOHH</shortName>
            <ecNumber evidence="11">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LIA1</name>
        <name evidence="14" type="ORF">P170DRAFT_381076</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC15"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC15"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381076"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="12">
        <location>
            <begin position="254"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB50416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="338" mass="36939" checksum="E531FB3DE8B2E15F" modified="2018-02-28" version="1">MAPVVPNPEAGVDATILNLRKVITDESEPLARRFRALFSLKHLACLEPATENTLPAIQAIAAAFTSQSALLKHELAYCLGQTRNPDSVEYLQHVVKDTQEDAMCRHEAAEALGALGYDNSLEMLKALRDDENELDIIRETCDIAVDRIIWENSEERQAEKLKPSDFTSIDPAPPLPLASSQPSISEMEQTLLDTKLPLFQRYRAMFALRDLASPPDLPTAVDAIQALAKGLKDPSALFRHEIAFVFGQLCHPASVPSLTDCLSDQQEAGMVRHEAAEALGSLGDVEGVEETLKKFVNDPEQVVRDSIIVALDMAEYEKNGEIEYALVPDSAPAAVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCS2</accession>
    <name>A0A2I2GCS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bis-tetraphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_435856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705986.1">
        <property type="nucleotide sequence ID" value="XM_024849036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCS2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCS2"/>
    <dbReference type="GeneID" id="36556735"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435856"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="205"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="345" mass="37574" checksum="6F6CA7AEC94E9F14" modified="2018-02-28" version="1">MQLGLSENLSALVARRFVAAKDGGHLLFSQTQLTTVSASGVPFQLRYCPALAKKPTATPKSDQGPKAPKPDPFQDPSSELLIAQIPRENPSHFLVLNKFPVIPNHFILATKPWKAQTDLLEKDDLEAAFSCIKEWGSQPDGTESRRLFAFFNSGDESGASQPHRHLQFLPVEAMAQGESGGWQPLIDVVSSQPPPSGSEYRCLSHFPFAHFALPLPSNPSADTLHAIYLSLYRTALATAKERPSAYDAKASSGPAAISYNLAMTDSVMMICPRRNESSRIPVDPAVSQEIAEAGVVSLNGTLLAGTLMVKAEAEWDQLRRNPETLVKVLTEIGYSQPDLRELSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD98</accession>
    <name>A0A2I2GD98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oligoxyloglucan-reducing end-specific xyloglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_463938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706167.1">
        <property type="nucleotide sequence ID" value="XM_024852205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD98"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD98"/>
    <dbReference type="GeneID" id="36559903"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463938"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="815" mass="87710" checksum="AD9049A728D4AEC5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDV6</accession>
    <name>A0A2I2GDV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF92 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_436147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706377.1">
        <property type="nucleotide sequence ID" value="XM_024849096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDV6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDV6"/>
    <dbReference type="GeneID" id="36556795"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436147"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="36371" checksum="540B92895E49F496" modified="2018-02-28" version="1">MKPFIAIPGIFALLYRAWSRKSLTPLGLVAAGLTASAHALHPWSAPFALLGVFYLSGMRVTKVKHDVKESLTLSASGSHGGEGQRTHIQVLANSIVASVLILFHTRALAVSGLDAGCFSNGGHASDLLMVGIVSNYVAVAADTFSSELGILSKSKPRLITSPTLRVVPPGTNGGVTGTGLLAGALGAVIVAATSAWLIPFCSSGNDTLNLIPRAQWILGFTAWGTLGSLLDSFLGGILQASVVDKRTGKVVEGTGGKKVLITPSGVAGTSTSTAVPASTETQNTRQRKSEAEAAETTDVNDAGSRHESRRVESGWDILDNNAVNVLMTAIMSVGGMGVASWIWGLSIGDITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDX9</accession>
    <name>A0A2I2GDX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_436145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706372.1">
        <property type="nucleotide sequence ID" value="XM_024849095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDX9"/>
    <dbReference type="GeneID" id="36556794"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436145"/>
    <dbReference type="OrthoDB" id="10447103at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="83" mass="9516" checksum="5F4F88BB77F54AAC" modified="2018-02-28" version="1">MFISTLYSDILLLSILFLWKFGPHLGLFLKNLSPFPQSPLLKKNSSSGPFPKHLLILKAGLLLLFPITKYYPRLLIKHKPKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE12</accession>
    <name>A0A2I2GE12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CrcB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_436213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706441.1">
        <property type="nucleotide sequence ID" value="XM_024849113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE12"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE12"/>
    <dbReference type="GeneID" id="36556812"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436213"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB51139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="404" mass="42972" checksum="602EEE0E667006A6" modified="2018-02-28" version="1">MSNANAVLDTGAPPPIQDAAQRQVDSLPPTNDKPSGAQPPAKHATQLYTLSYLVFFAIFGTLARLGLQALTVYPGAPVVTGVLWANVGGSLLMGFFLEDKNLFREEWGTDDISANHPGDATEQAKRHKSVKKTIPLYIGLTTGFCGSFTSFSSFIRDIFLALSNDLADPSAPSIASRNGGYSFMALVAVILVTVALSLGALVCGAHLALALDPVVPAFPFRLTRRLLDPLFVCLGWGCWLGAVFMAIWPPDRHAASPETWRGQAIFAVVFAPLGCLVRYYVSLLLNTRIPTFPLGTFAVNIGGTIILAMCFNLQRVDGLGTALSSSAASSSILTSCQVLQGVMDGFCGSATTISTWVAELNGLSRRRHAYVYGISSIGVALGFFVIIVGSLRWTLGFVEPVCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE57</accession>
    <name>A0A2I2GE57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_406888</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706488.1">
        <property type="nucleotide sequence ID" value="XM_024846651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE57"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE57"/>
    <dbReference type="GeneID" id="36554350"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406888"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014195017" description="chitinase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="477"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB51186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1220" mass="132563" checksum="75A98292521E7A26" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEV0</accession>
    <name>A0A2I2GEV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706715.1">
        <property type="nucleotide sequence ID" value="XM_024848489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEV0"/>
    <dbReference type="GeneID" id="36556188"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433420"/>
    <dbReference type="OrthoDB" id="4490775at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="91" mass="10355" checksum="91446A17D5C38EC6" modified="2018-02-28" version="1">MGLTKILLKAIIIPVVVVLLMGVLVWFLIKRHRDRKREEKAIEGQQFQQFQPPPITQWATGPHPASPVSAMHKPEPVFYPVQQPVDPRGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEY9</accession>
    <name>A0A2I2GEY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_400256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706699.1">
        <property type="nucleotide sequence ID" value="XM_024846315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEY9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEY9"/>
    <dbReference type="GeneID" id="36554014"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400256"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="732" mass="82841" checksum="6459B0BDB3540E3D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF05</accession>
    <name>A0A2I2GF05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative FAD-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_400309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706733.1">
        <property type="nucleotide sequence ID" value="XM_024846317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF05"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF05"/>
    <dbReference type="GeneID" id="36554016"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400309"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="476" mass="52577" checksum="8D57D8165457F732" modified="2018-02-28" version="1">MGSAERPFRVIVVGGGVGGLTAAHTLHRAGIDYVVLEKGLVAPPMGASIGIYPHGSRILEQIGCLADVEAECVSLGKSQNLLPDGRTIFSSDFFHYSRTYHGYPIPVLERRRFLEILYENTPDKTKIRSETAVVDVIDHDKGVKVVLADGSVEEGDLVLGCDGVHSNIRNIMWRNANAAVPGLITTAEKKSLICDWTALAGFSPTVPGMSNCNMTCTHYPGKSFLVIGQKKYTFWFVFFKNEETRYWPSSPRWTAQDAEKRAAECADCPISDTQVFGELWRSRVRGDLVNVEEGLFKHMYFGRIVLAGDAVHKMTPNIGLGGNASMESVVVLSNLLHRAVQAHSSGKPDKKMLGAILEEYQTLRYDRMQKVIHFSGEATRLQAWDSLYYKAMSRVIPYLPDTTSAKKTGELIKAAAKLDYVPTSPARKGTVAWEDEGQRVLGAHQAVVSSFRRLIQIPVVLLSFGLSFFYLSGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFB8</accession>
    <name>A0A2I2GFB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS peptide transporter Ptr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_471511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706880.1">
        <property type="nucleotide sequence ID" value="XM_024852848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFB8"/>
    <dbReference type="GeneID" id="36560546"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471511"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17350">
        <property type="entry name" value="MFS_PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="573" mass="63205" checksum="17E698DB5234176A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFK1</accession>
    <name>A0A2I2GFK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706962.1">
        <property type="nucleotide sequence ID" value="XM_024848517.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GFK1"/>
    <dbReference type="GeneID" id="36556216"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433537"/>
    <dbReference type="OrthoDB" id="2549237at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1593" mass="180068" checksum="CAE5DEBB241321B9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG60</accession>
    <name>A0A2I2GG60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin assembly factor 1 subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_422817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707175.1">
        <property type="nucleotide sequence ID" value="XM_024847466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG60"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG60"/>
    <dbReference type="GeneID" id="36555165"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422817"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="323"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="7">
        <location>
            <begin position="520"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="64590" checksum="8FDA31360D076B80" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGP8</accession>
    <name>A0A2I2GGP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_377519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707356.1">
        <property type="nucleotide sequence ID" value="XM_024845405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGP8"/>
    <dbReference type="GeneID" id="36553105"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_377519"/>
    <dbReference type="OrthoDB" id="4497058at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="305" mass="34839" checksum="226BE3945C4358B6" modified="2018-02-28" version="1">MSVTINSKVVELDDLIPKVVDRECEDEDVERLIPWVFQHSDIVDGDCLESGPKEGCEFQPLFYHLQSYRCELQANDSDDTGISNIFVPSETITLPRKSWRMPGREQFTHFINDQCTITKLLLQSIYLSLDHDVKAPDPKVEFTTAARDLKYTIGGSRYATRLEGAVLAGPRAQYMPMIAFTGWFIGQTWNAFLMETFSAMLGQLTRNLSLLQTGFEDQEVFIVGFYGPYLHIARGFFTKDRISRVHAEGNFDQGPVSLQFTRGYDLFLKEDWLEATRALTRLLRYLHSGKSRVGAVQKERRSPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHB2</accession>
    <name>A0A2I2GHB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intracellular protein transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_402280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707571.1">
        <property type="nucleotide sequence ID" value="XM_024846416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHB2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHB2"/>
    <dbReference type="GeneID" id="36554115"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402280"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="341"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="906"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1100"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="915"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1128" mass="126414" checksum="D8BF5A1D950EB6A5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHB8</accession>
    <name>A0A2I2GHB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_99520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707574.1">
        <property type="nucleotide sequence ID" value="XM_024855465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHB8"/>
    <dbReference type="GeneID" id="36563172"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_99520"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="163" mass="18214" checksum="564C09DD67685E78" modified="2018-02-28" version="1">MTVILQLHRWHALFVVRSRQVRPVALSVRQMASGDTPAWLVPDMSPPCRCGAACRCRCRRSGEDQGSFRDGVNDDASTNAVVLVLGELELGLILHWSPCILCREPNTSMHRHHTLAHSAIIRTCRTSSQSPADSGQLPLATGDKYFQIERNHRDRCPLERGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHK9</accession>
    <name>A0A2I2GHK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_348482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707667.1">
        <property type="nucleotide sequence ID" value="XM_024843681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHK9"/>
    <dbReference type="GeneID" id="36551381"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348482"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="8">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="254" mass="28616" checksum="88E15FA045F2930C" modified="2018-02-28" version="1" fragment="single">IVAVHGLGGNWLRTWESEKDNWNWVESSIGPGLLEEAGIVARILSFGYNSNIFATQSVNDIQQVAEILIEGIYNAVRKMDNQSPTIVFIAHSLGGLVVKKALNIAWNNSDRYGRLLDQIKGCLFLGVPHRGADLASWAKLPVRTFQLLSGGSLGNNNFLDSLQRNSTVWMDISRDFVHRAKHLQIRTFHETEKFMNQIIVDRDSAAMNLPNELVLPLDSSDHRTICKFSQDEEERYMPVWDALMELVSFGQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHS0</accession>
    <name>A0A2I2GHS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_402612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707733.1">
        <property type="nucleotide sequence ID" value="XM_024846432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHS0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHS0"/>
    <dbReference type="GeneID" id="36554131"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402612"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF4">
        <property type="entry name" value="FUNGAL N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47994" checksum="3D95D50CE78210BE" modified="2018-02-28" version="1">MSGIEILGVIAGTLQLAEIGAKLSVKLCLFYREIKDANQSMQSLSSHMSLTSNILHELGITLQQDEHVKNCSEQMILSAQDVLDECKTVFKHIEETIEKQKPGDEKGFLQRGIRKITVALLERDLDVLKSALERLKSTMLLMLQVLMYAAQLRRRTEFHVLENQQLLIQTLLEEKKGSEARSNRSGELARPAELFDYNDALQLHASATKPEGSLVSHPLVSNELNKYYTFIKQVLRQIDAYRLDFSDDRFFRVRNGILNVHFTEVELLQSHYGNKAIEVFKDSIFELQNDHSTNPYDSKQARHNPSDPFASSAIGFTPITEADRVNNPEPGGKLPCPIEDVPTRCSSPIVKVESYSRGNSSTWECSFPSTSGVSDQYHGEDIGDYEQPDKIADQLVNDSWENLVLYWTTLTIHEIHPPVQSNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHT6</accession>
    <name>A0A2I2GHT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_453823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707742.1">
        <property type="nucleotide sequence ID" value="XM_024851391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHT6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHT6"/>
    <dbReference type="GeneID" id="36559090"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453823"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="413" mass="48146" checksum="B4195F8F531BAF63" modified="2018-02-28" version="1">MPPTSGSAIGDVDSDDYVAQVLAGEARDSSLKYSAQGLGAYMPKRPTGAAPKPNTRFLRHIIKETDTHNAALKRKEEREARERMRQLRTQATASSHDSRETRRRQSTTDDRDSRRERKYDREDRHRSHRRRPRSRSASADRERSSKYRHRHETEEDRHRSSRRSRRHRSYSRSRSRSPKEDRDSYSRRHRRHHRRRSGSPSRSRSRSPRARESRRDKYSERSSRHRSREREASRKHTTTTRKESPTAPAQQNGYDSDPLEDLVGPLPAKENAPIRSRGRGAYRPNASNIDAHFAADYDPALDVQLEDDDASTKKSTRRPVPGLMTGDDDWELALEAVRDRARWRQRGEDRLREAGFNDSFVERWKSNTTSTGAADDSEGRLEDVKWSKKGESREWDRGKFVDDEGHIDVKALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI46</accession>
    <name>A0A2I2GI46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_106165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707852.1">
        <property type="nucleotide sequence ID" value="XM_024842294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI46"/>
    <dbReference type="GeneID" id="36549989"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_106165"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014192160" evidence="2">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="118" mass="12881" checksum="B4290C30632ED092" modified="2018-02-28" version="1">MNPQFLSLLLGTLTLAIPIPVPSHGVFVTNNNIDNPINNIHPTPTPEPPVDPPPTVAFISNINTHSYYQPQRQHLLSVPPSPKPDKTPPHRPHPPKGKNPRGNGMCPIQSHHSNQSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI47</accession>
    <name>A0A2I2GI47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_339443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707857.1">
        <property type="nucleotide sequence ID" value="XM_024843387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI47"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI47"/>
    <dbReference type="GeneID" id="36551087"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_339443"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF11">
        <property type="entry name" value="SHIKIMATE O-HYDROXYCINNAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56900" checksum="23BAF1FC39A31227" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI60</accession>
    <name>A0A2I2GI60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_402827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707856.1">
        <property type="nucleotide sequence ID" value="XM_024846448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI60"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI60"/>
    <dbReference type="GeneID" id="36554147"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402827"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="297" mass="32591" checksum="9075E48EEEECBD55" modified="2018-02-28" version="1">MLQIARTHGITGIDTARLYGLGISETFLGQQNAASEFEITTKAPSGFLPDSATKSAIIQNGTLSLEALKTSKVPIYLLHGPDDSVPLSETLDGVQELYLRGAFEKFGLSNFSLPQIREVYEYNKSKGYVLPTVYQSIYNLVARNNETELFPALRDLGFSIQVYSPIASGFLVKKPADIEQQKGKWDPSTGLGKLLQGLYGKPELLNFLREYIQLAEESGNSQAGLAYRWVRYNSALKGELGDSVLLGANGPEQLRGTLADLGQGPLEDWVVQRLDALWEGIREVAPVDNLTTFKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIJ9</accession>
    <name>A0A2I2GIJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_378769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708014.1">
        <property type="nucleotide sequence ID" value="XM_024845462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIJ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIJ9"/>
    <dbReference type="GeneID" id="36553161"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378769"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="257" mass="29018" checksum="2BD3E37919A13789" modified="2018-02-28" version="1">MVPSNGSHQADGRTWRNYFPDGDLWVFGYGSLIWKPPPHYDQRVPGYINGYVRRFWQVSTDHRGTPEVPGRVVTVIEREFWETLDDPLAHLENSDSSTSRVWGAAYHIPASHAEEVHDYLDEREIDGYTAHFTPFHAFGSTDVPESKPITCMVYIGQPTNPQFLRDPARREPQDVAEVISRGRGQSGNNTEYLYLLEKALESVGLGSADGHVTDLVRRVKAIEGAEEAARAEDAAERDLRKSLSRSEEEAHRNIGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ05</accession>
    <name>A0A2I2GJ05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_423674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708162.1">
        <property type="nucleotide sequence ID" value="XM_024847519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ05"/>
    <dbReference type="GeneID" id="36555218"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423674"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="281"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="512" mass="55323" checksum="01AB98D228DC592D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJP9</accession>
    <name>A0A2I2GJP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_123304</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708404.1">
        <property type="nucleotide sequence ID" value="XM_024842368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJP9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJP9"/>
    <dbReference type="GeneID" id="36550063"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_123304"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="164"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB53102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="434" mass="48068" checksum="EECF24472AC5BCE8" modified="2018-02-28" version="1">MSNTDFLGRAIDTVKKAIEHDNEGEYEKAYQLYYSSLELFMLALKWEKNPKSKEMIRAKTGEYMDRAEKLKNHLAQSDGRKKPSAVGANGSVAQGSGKGGKEEEDGEDADSKKLRSALAGAILSDKPNVQWEDVAGLESAKEALKEAVILPIKFPHLFTGKRQPWKGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFNMARENKPAIIFIDEVDALCGPRGEGESEASRRIKTELLVQMDGVGKDSKGVLILGATNIPWQLDAAIRRRFQRRVHISLPDINARMKMFMLAVGQTPCEMSQGDYRTLAEMSEGYSGSDISIAVQDALMQPIRKIQTATHYKKVLFEGAEKLTPCSPGDRGAVEMSWMNVEAEQLLEPPLVLKDFIKAVRNSRPTVSHEDLSRNEEWTKEFGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKA6</accession>
    <name>A0A2I2GKA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_379907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708589.1">
        <property type="nucleotide sequence ID" value="XM_024845508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKA6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKA6"/>
    <dbReference type="GeneID" id="36553207"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379907"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="55"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="313" mass="33962" checksum="1122A040C2736D31" modified="2018-02-28" version="1">MSENIKSVNIPNITWKTAADIHLPPNFDEKKKYPAVVSAHPIGSCKEQTSGNIYGKAIAEAGFVVVAFDASFQGASGGEPRFIEDPEFRVSDFRFVVDYIQTLPYVDAERIGVLGICGGGGYAINAAMTDYRLKCCVGITPVNFGRLSREAFGNFDPAGSLEKMAKQRTIEAQGGQRLVINLLPPSVEEAKKSTADIDVIEATEYYKTPRGQAPNGCTSGLYSFNSAALAWDAFNHAEVLMTKPLMAVVGDKPGGFGAYRDAQEIYGRAGSQEKRIVVLPGISHYMLYDKPEAVKPALDQVLPFLKDHLGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKC1</accession>
    <name>A0A2I2GKC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_348851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708635.1">
        <property type="nucleotide sequence ID" value="XM_024843703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKC1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKC1"/>
    <dbReference type="GeneID" id="36551403"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348851"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="172" mass="19359" checksum="B2963D64A6BEC4A9" modified="2018-02-28" version="1" fragment="single">IDIARRRNANDPRVEFHVADCGQPLDVGQFDVVLSCWLLNYASNDAEMLDMWRNIFNSLKPGGRVVGISPDLGAIEEGRALPVGNYHGQGVEVIERLDNGGVKVQTTMYTSEPFSFQSYFLPREMYNRGAKLAGMKDVQWVTHPNFEVAGIEEQEILQRPLFNNYTAIRPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKI8</accession>
    <name>A0A2I2GKI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein efr3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_129410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708704.1">
        <property type="nucleotide sequence ID" value="XM_024842403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKI8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKI8"/>
    <dbReference type="GeneID" id="36550098"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_129410"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="950"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1140" mass="124754" checksum="BAE7289CA38283F2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKN8</accession>
    <name>A0A2I2GKN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lovastatin nonaketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_454498</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708754.1">
        <property type="nucleotide sequence ID" value="XM_024851439.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GKN8"/>
    <dbReference type="GeneID" id="36559138"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454498"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="6"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="942"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2383"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3515"/>
            <end position="3595"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="942"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1092"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2468"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2468"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2497"/>
            <end position="2516"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB53452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="3951" mass="435653" checksum="318499C3BA269984" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL08</accession>
    <name>A0A2I2GL08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_435168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708874.1">
        <property type="nucleotide sequence ID" value="XM_024848878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL08"/>
    <dbReference type="GeneID" id="36556577"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435168"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF73">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="528" mass="58461" checksum="9EAE45E556186C7B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL58</accession>
    <name>A0A2I2GL58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_460009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708912.1">
        <property type="nucleotide sequence ID" value="XM_024851902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL58"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL58"/>
    <dbReference type="GeneID" id="36559600"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460009"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014165649" evidence="1">
        <location>
            <begin position="17"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="42"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="220"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="671" mass="72864" checksum="319E1002C71C5D89" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL59</accession>
    <name>A0A2I2GL59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_469075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708889.1">
        <property type="nucleotide sequence ID" value="XM_024852591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL59"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL59"/>
    <dbReference type="GeneID" id="36560289"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469075"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="80"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="270" mass="29876" checksum="448A6B6EAD348C38" modified="2018-02-28" version="1">MTAAADLSAEAELYFIPGTVHLLDLQGHMNVRHAADHTDVVLVPAPSNHPDDPLNWSPRRKHLSAFCMALYVGCSSSSPFTDSAWRYVLVVGICASMLYSTLATLSKKSGLSVNNLNAGTGYMFLTYGWGCVLFQALALQYGKRPAYLISLLGTIAIMVWQPFITKNGEWIAAKLLQGLFGAPMESLAEISVSDVFFTHERGLYMAIYAMALAYSNNLAPLMMGFINDGQSLEWTFYWCAIFCGFALLFCFFFMEETNFPRSNITGQEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLY3</accession>
    <name>A0A2I2GLY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Elongation factor 1-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_504781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709203.1">
        <property type="nucleotide sequence ID" value="XM_024854228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLY3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLY3"/>
    <dbReference type="GeneID" id="36561934"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504781"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="225" mass="24790" checksum="505EA827E4057276" modified="2018-02-28" version="1">MSFGKLYYYPKAPRATMCLYIAELNNLDVELAEAWPIKVDASKGGVGAEYLSKFPTGKVPALERPDGYTLYECIPVSIYLAKQNPNTSLLGSTLEQEATIIQWSSFASTELLPPIMAWINPVIGKAPSSPDILANAEKVSEPMLAVVERAIGGGRKYLVGDVLTLADLFIVTALARGYQFVFDKAWTEKHPALHEYYWAIKSDAIWTKVDGKPYVLDKVGGKPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GME2</accession>
    <name>A0A2I2GME2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_7759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709363.1">
        <property type="nucleotide sequence ID" value="XM_024855381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GME2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GME2"/>
    <dbReference type="GeneID" id="36563088"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_7759"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="387"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="663"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="987" mass="111289" checksum="E0A0B86BF4CBCD13" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMR9</accession>
    <name>A0A2I2GMR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709484.1">
        <property type="nucleotide sequence ID" value="XM_024848125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMR9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMR9"/>
    <dbReference type="GeneID" id="36555824"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431813"/>
    <dbReference type="OrthoDB" id="3556996at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014126862" evidence="1">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="210" mass="22947" checksum="70798E9B830F4DA7" modified="2018-02-28" version="1">MNLLLTTLLALSTGTLSQSITPPEGCPLPRWTVTNFQWHNGSKSLDCIHNEADRNAKGCLCSGGWCEPNPDTCNGTMVPLCYTGMPNYEPWGYGPPQTLDIDFADGLSCHDEYIGYRIHDIGNGASNCGYADRGLGRVVSFYGTSNKEVSVGHVDYVLGRGHALECQDGRKITYSGRTDFELNCVHDSFFNATCSAGSFQVPVLAFEWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMT6</accession>
    <name>A0A2I2GMT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_431815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709488.1">
        <property type="nucleotide sequence ID" value="XM_024848126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMT6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMT6"/>
    <dbReference type="GeneID" id="36555825"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431815"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000107">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="926"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123979" checksum="8893B16C435C32CA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMW1</accession>
    <name>A0A2I2GMW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_431843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709508.1">
        <property type="nucleotide sequence ID" value="XM_024848132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMW1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMW1"/>
    <dbReference type="GeneID" id="36555831"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431843"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="67"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="194" mass="21843" checksum="110EFC42DB4C51B9" modified="2018-02-28" version="1">MANRQITRRILIGAVITAILLCFFLVRPQDSPNPAIRSSSQVAIPEPAALTNNDVTKGEVVMPKLGNETAKAELGRATWKYFHTMLARYPEEPTTEQQEILRSFIYLFARLYPCGECASHFQGHLTKYPPQVSSRNIASGWGCFIHNEVNAMLKKPEFDCNKIGDFYDCGCAEDEKSDDKKQELQSQNQDPSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GND8</accession>
    <name>A0A2I2GND8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_432031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709696.1">
        <property type="nucleotide sequence ID" value="XM_024848174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GND8"/>
    <dbReference type="GeneID" id="36555873"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432031"/>
    <dbReference type="OrthoDB" id="5304367at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="83" mass="9034" checksum="747D8D91792273A9" modified="2018-02-28" version="1">MSKKTLGRTSGSLNAPIAAFTMAILLTTYCVTSINSARREAQVSAANPTPTSRPRAPTDRNDQPAWVRQALEESRESEQRKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNX1</accession>
    <name>A0A2I2GNX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_432204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709873.1">
        <property type="nucleotide sequence ID" value="XM_024848210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNX1"/>
    <dbReference type="GeneID" id="36555909"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432204"/>
    <dbReference type="OrthoDB" id="10518613at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014148989" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="88" mass="9328" checksum="7BC40EFEE454DF9F" modified="2018-02-28" version="1">MRLQALLPALVAAATAVVAQDSGKVALVMADNACWAEFTDLLGCNGRSSEPIGDWDGMHCTGMLRELTPRLPPYPALSSHPLHAKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPI0</accession>
    <name>A0A2I2GPI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_460807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710065.1">
        <property type="nucleotide sequence ID" value="XM_024851971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPI0"/>
    <dbReference type="GeneID" id="36559669"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460807"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="274" mass="31549" checksum="6905ED20208E9534" modified="2018-02-28" version="1">MTSIYTNWFTSVKDEGLSFSPFHLTTLQSYLDGSIPVTDAASQLLDPSQPQRWDYSCYPWEVLLFLAKDHEEAHEDIISLLHAIFDLPPPFNTDEANWTLEKETIFPQVWRDLRDSLEAQYHEVKILSDPMYAKWVNYHAFTGRLISSSLMEPYYWALHLTVEALETKVDDSKPTAKQDGNIAAAGQYFIHAAKDLLHNPFRGAEGTHATSWGKDSQMWQEEQGFSTERLGFWRRRFGQLRVLETLSEGTREAARRAEVGMEKAERQGKKKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQH1</accession>
    <name>A0A2I2GQH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_33011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710430.1">
        <property type="nucleotide sequence ID" value="XM_024843361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQH1"/>
    <dbReference type="GeneID" id="36551061"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_33011"/>
    <dbReference type="OrthoDB" id="3938867at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="820" mass="93578" checksum="F1B6B5CB8185FC96" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQJ4</accession>
    <name>A0A2I2GQJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_432666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710426.1">
        <property type="nucleotide sequence ID" value="XM_024848314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQJ4"/>
    <dbReference type="GeneID" id="36556013"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432666"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="350" mass="38297" checksum="528B18726C59B785" modified="2018-02-28" version="1">MPPRVRLSTGRLPQPLRQTRFRQYELPSVTRCASTATTPAPSVEQMTKSPAPIARYPPSQAPSHRNPEYRRSQLLRQYTSLIRTTPLMVFLQHDNLQSVEWTAIRRELTSALRKVDEQIVAEGRNTPSLAPHIKVQIVQTSIFEAALRIVEYFRPSQAALASEQPPSAVNPVTQTSAELPPTGSKDDPSLTHDLSRAAHDAVLHMKGKHELSTLLAGPIAVLSIPDVSPEHLKAALTVLAPKACGFPSPTRKANPGWHELPVQNGLNKLALLAARVDGKVFDVDQTKWVGGIQGGMDGLRSQLVQSLQSMGSGLTNALEGAGKSLYFTLESRKNVLEEEQKGPEEQKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQP3</accession>
    <name>A0A2I2GQP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_470605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710491.1">
        <property type="nucleotide sequence ID" value="XM_024852777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQP3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQP3"/>
    <dbReference type="GeneID" id="36560475"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470605"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014133802" evidence="2">
        <location>
            <begin position="29"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="65"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="297" mass="32673" checksum="F1E91FDB0F9C749C" modified="2018-02-28" version="1">MSLLYYIYLRILVICVRLWARMTGGTSASPNVVYSIPSRNPKRSIPVHVYQPTQRQPPGQVGPVLINFHRGGFVIPAHGSDDSFCRKVSERTGYTVIDVGYRLAPEHPFPAAHEDAEDAITWVRSQRETFDTSKVALSGFGAGGSIVLSLASVVYPPSAFHCAIAFYPTVDWTIDPGAKMAPNPHGPPISAWMMRLFKNAVFQGQVNLADPYVSPLCAAPERFPPRVMIVTADGDRLAPEGNELGRRLELKGGGRVIPLQVKRCSHAFDKTAQEGSPQKTEKRNAYFLAVDMLRSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR25</accession>
    <name>A0A2I2GR25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_461231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710637.1">
        <property type="nucleotide sequence ID" value="XM_024852012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR25"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR25"/>
    <dbReference type="GeneID" id="36559710"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461231"/>
    <dbReference type="OrthoDB" id="4220319at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="17950" checksum="DCC43E45EF97F5D0" modified="2018-02-28" version="1">MWKATTRVSQLGQSAIRNSSRVQTRTATPPLPAITHVRRFQAFPSLQTTREQKGEEDRTHDRTVLDPQRSEVSKSGTDNEVAAHPAAYDPHRTSPESEIEATEEESQREGKVSNPLDMSPANKETSKARPPQEGGPDRNAEKEKLSSRGSARKHGKVKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR26</accession>
    <name>A0A2I2GR26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_374992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710625.1">
        <property type="nucleotide sequence ID" value="XM_024845304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR26"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR26"/>
    <dbReference type="GeneID" id="36553004"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374992"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013984456" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="526" mass="57661" checksum="A45BA7D0C1428295" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS38</accession>
    <name>A0A2I2GS38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_375627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710991.1">
        <property type="nucleotide sequence ID" value="XM_024845326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS38"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS38"/>
    <dbReference type="GeneID" id="36553026"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_375627"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="180"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="296" mass="32607" checksum="2D9B6A12EF51280F" modified="2018-02-28" version="1">MHESLILSTFDRLVECGLVLYDDKQRIIEHTDGNLKFQFVLTSALIKKPTLATAPAQEQSDARGPEKRAGSDIDTAGFEIGTIGDTHFVIANKFCFARPHLMILSLDGFRRQYEPLDEPDLAGAWQLLNAADTDSVAFYNCGRDGGCSRLHKHLQVMPLPANSFAAFLDADSPEEENETKVPFEWFYRRFEQDGVTPAALVGVYNELLLQATKVGAGRWEYTASAPSGAACPHNMILTKRWMIVLPRRRGAINKEAGVNSLGMLGVIAVATTKEIDNWVRLGLTESLGELGVPKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRD5</accession>
    <name>A0A2I2FRD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698495.1">
        <property type="nucleotide sequence ID" value="XM_024850367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRD5"/>
    <dbReference type="GeneID" id="36558066"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441653"/>
    <dbReference type="OrthoDB" id="4510611at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="94" mass="10458" checksum="24F581898ECC08EF" modified="2018-02-28" version="1">MMSCISGPAHFVQSALRNPHCHLPLVQIGKLRADFPSKAGWPNGKALDYESRDCRFDPCVGQYFLLFVFCLLVGLGDIFICFFAGGWGRCGMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRM1</accession>
    <name>A0A2I2FRM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_514540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698582.1">
        <property type="nucleotide sequence ID" value="XM_024855217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRM1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRM1"/>
    <dbReference type="GeneID" id="36562923"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514540"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="227" mass="24908" checksum="F7031914FFC68AD2" modified="2018-02-28" version="1">MAAMIHAPRKYHHLVAEQPEPATPASPAKTNLLGSWYITRSSSPFWIDKRNPTITLAADSKTDDGTRAPETLPLSALYQTAGPAPVLANQTSYQTLASSKVKTTAGMDRPVDGSSSFWGESGGSGGGEGPIQMEWRGSGWLRMVSARWEILGWGGEGEAEADEWLLVFADKSMFTPAGISLYTRRRTGVEDMEWAGIEEGLRRLVERYPEEGELRELALGMRVVRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRP3</accession>
    <name>A0A2I2FRP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_419194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698604.1">
        <property type="nucleotide sequence ID" value="XM_024847269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRP3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRP3"/>
    <dbReference type="GeneID" id="36554968"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419194"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="502" mass="57462" checksum="D067AE7608EA5E08" modified="2018-02-28" version="1">MHRMCFDDASWEKSEEVSDSFAIQFLSPDVLRPVGGFLVRHHSPDDPEQFSILQKGAFNISLQMEYENGSSAVMRFPLPGAAMFPEEKVKNEVAVMRYIQDRTSIPVPFVLHWGAKTESPLELGPFVLMEYIEHDTNMYDALNIPGCPRAERGILDPDISEEKLETLYGEVANILLQFSTLSLPRIASLDQIDDFTWEVTRRPLSMSMNELIRLGSLPQSKLPCTTFDTASSYFEALAELHISHLANQRNDAIDSADDCRRKFIARRLFLKLAREGRLTGKQSRFENGPFKLWCDDFRPANILLNQDLKIAGVVGWEYTYAAPVEFSHAPPWWLLIEKPEYWPSGLEGWCTEYERRLGTFLRAMIVQEDKAIKQGQLAEEQRLSGPMRDSWESGDFWIVYAARNNFAFDAIFWEKIDGRFFGSSSCSVEDVWRERLYLLTGGEKEEMEELVALKVGEMGSRVLAWDPDEYTLSYIEKAKTDTLKEEDRVDDCTGQGGSENQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRS0</accession>
    <name>A0A2I2FRS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_486173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698613.1">
        <property type="nucleotide sequence ID" value="XM_024853928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRS0"/>
    <dbReference type="GeneID" id="36561626"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_486173"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="253" mass="28625" checksum="4606D27DF7FAD3E4" modified="2018-02-28" version="1">MTDAPSFLAPRPPDGTKLEMDFLDSTFFKTPGQRLPTPAEVRALSTDLYTSPQPKPITFRNPDIFVKFGRYVTVAEAQCLWMLQRVFQGTVPVPEPFGWRVDDEGFVIHPFTHQNLPDYTSTTGSPPSLPQSRLPASLEYKDPCRDLLPDDGAVTFSHADLHRGNIMISSSAPFRVLAVVDWGQAAWYPDYWEYCKALYTCWYEDEWRRDWVNRFLSPRLLEPQVFSEYTMAIGAVWIGLILERGGGGGALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRU8</accession>
    <name>A0A2I2FRU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698641.1">
        <property type="nucleotide sequence ID" value="XM_024848020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRU8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRU8"/>
    <dbReference type="GeneID" id="36555719"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431288"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="136" mass="15518" checksum="2AE835E2E499E960" modified="2018-02-28" version="1">MLITQILRLHVSVGKARLAALPSADLMVSFEFNKYGSHKVVRLRGRAESHTHLFANKTHPYDDVERIIAHARKSPRKYRQFLKGIDSIRVSHWVKSQPHIRMGLAPETKQSGTTGCYTRNPRAMNEPERNSPGSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS17</accession>
    <name>A0A2I2FS17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_419357</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698732.1">
        <property type="nucleotide sequence ID" value="XM_024847278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS17"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS17"/>
    <dbReference type="GeneID" id="36554977"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419357"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="158"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="266"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="439" mass="47676" checksum="802D2A174EA2E071" modified="2018-02-28" version="1">MATVSPNPVPFSEPPYLRGLPSPYYSQGHRQFQSRCRAFIFENLLSRAMEFEQQAEVPAEIFHKFNEHNMLLPNLPAPLPIDWLKRLGVHDILGVKVEEWDYLHAGIYADELARSGLSTGSGINAGFAFGIPPIIKFASRELQERVLPDLLLGKKRACIAITEPDAGSDVANITTTAVKTEDGKHYIINGSKKWITNGIWSDVATMAVRTGGPGPGGLSVVLVPLKGHPGVTMRRLTVSGQKTGGTTYIELDDVKVPVDNLVGREGEGMRIIMTNFNHERLLIAVGVNRQARVALSAAFSYVLKRQAFGKPLMDQPVVRHRLAKAGAELETLSAFLEQLLYQLCHLSKAEADLQLGGITAMAKAKAGMVLNECAQCAVLLFGGSGLTASGQGELVEAILREVPGARIPGGSEDVLLDLGIRQLVKIYRAQEKKLGQSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS40</accession>
    <name>A0A2I2FS40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_77420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698743.1">
        <property type="nucleotide sequence ID" value="XM_024855379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS40"/>
    <dbReference type="GeneID" id="36563086"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_77420"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="94" mass="10561" checksum="0F38B7955F6BE26E" modified="2018-02-28" version="1">MMDVRGHRHPRHATNEAHHFHFETGARPSKTSGEDARRPRTSPRNPPHCPAVPRVSRSLPGQPSRQSVRGKSLGLEKIRIIASGPWQSTEPRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSL1</accession>
    <name>A0A2I2FSL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TMEM1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_57800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698914.1">
        <property type="nucleotide sequence ID" value="XM_024855280.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FSL1"/>
    <dbReference type="GeneID" id="36562986"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_57800"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24965">
        <property type="entry name" value="TRS130_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="8">
        <location>
            <begin position="627"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="916"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1241"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1434" mass="159902" checksum="D93BDF419BBC8F01" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTA3</accession>
    <name>A0A2I2FTA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative prefoldin subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_514152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699146.1">
        <property type="nucleotide sequence ID" value="XM_024855180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTA3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTA3"/>
    <dbReference type="GeneID" id="36562886"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514152"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="18642" checksum="630FCCEEA6AC2012" modified="2018-02-28" version="1">MPPPNTPASDPPPGAVNINSLSAQQLRALQSRLSSELEHLTSSHAKLRAAQSKFRDCVRSINEGVLGSEKKGTDGKDEILVPLTSSLYVKGKLADREKVLVDVGTGFYVEKTPQKAIEFYNEKIKTLDANLVELEKIVQTKSSQQRLFEDALRQKLLSEGAAGPSGQAAAAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTW3</accession>
    <name>A0A2I2FTW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_514325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699343.1">
        <property type="nucleotide sequence ID" value="XM_024855197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTW3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTW3"/>
    <dbReference type="GeneID" id="36562903"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514325"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="186"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB44041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="599" mass="68110" checksum="3AD184F4FABF9A2F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW75</accession>
    <name>A0A2I2FW75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_479432</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700194.1">
        <property type="nucleotide sequence ID" value="XM_024853675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW75"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW75"/>
    <dbReference type="GeneID" id="36561373"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479432"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB44892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="520" mass="56805" checksum="C6F4ABEA34D570E3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWR7</accession>
    <name>A0A2I2FWR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_416002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700385.1">
        <property type="nucleotide sequence ID" value="XM_024847096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWR7"/>
    <dbReference type="GeneID" id="36554795"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416002"/>
    <dbReference type="OrthoDB" id="5427526at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="419" mass="45960" checksum="E73FAE9C137170DC" modified="2018-02-28" version="1">MPSVPPLKLSHRHTQSQASSVDFDPISPGTYAPNHFSHGSPRSSAPNSPGLPRQHHAQSINGFQRMSGDFGGAADMGGGLGNLADELADAWEEEEGGYGYASGQEMEHVPGASQRPDRSDTEDEYHMANRTPSSGYSSERGSLHPPRPKTRNGANRHRRHESHYDGSDYGNESDLEEADISPSLESQMAEIESLARRGIENNGSENDHVIQRAVEALRDLGGQSGIENNAMRLITAHSSITSHLTHQTRTLQTLTHPLLFSPFPILSSDAIDALIPLIDDDLLPNLPYPFPDPSRSRPDTPSQTSTLDPLVSLQTLVSQTSDITLSLRGLSDTLYESRQLTSTASRRLRSARELVAELRREEEGREEGTRWIERGDWDRRLKDREAGRECGDVVSGFEAICGEWRERLFGAAGAEVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWY1</accession>
    <name>A0A2I2FWY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_467718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700445.1">
        <property type="nucleotide sequence ID" value="XM_024852491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWY1"/>
    <dbReference type="GeneID" id="36560189"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467718"/>
    <dbReference type="OrthoDB" id="3140657at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="465" mass="54781" checksum="54558FE2390EE639" modified="2018-02-28" version="1">MGFQSLPNELLDRIAYHADHESLLNLRLVCQSLSDICRKWLFQYTCVVPTDESCERFESILDHPELASCVTKVYLDTTKWDHEIEIEEYDSDDEDIESDSDGDEESDKHHVNEIWIPRWYSNLFNRLEELPRLRGVVLRFHHECQSPLWVEMMTDIIPQEPNFRRYVLKLFMESLALLPQPVRELGIHDLQNVNQSKEHIVENIRKVLGGLDTLRLNIANEHSKYYRPQDLQQDEPHRFFSELPSFWLKPTLANLEHLTLNSSNYFGFYPKFNPTGLHFPRIKTLAFGRLAFIHDSQLDWILSHADTLTELYLDNCPILYEVLIHDKERTYLDPASFASKEDLGDKHYATYDKRWYDYFNAINVGLPLLKHFRFGRCPYWRDGESTPFEQEQYIKISAPRDRYMVFCDGGESSPYMETTIYPEGVNLRTPRPDCYAEDQKALETLCAKLGQHAECDPIEDEFLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX24</accession>
    <name>A0A2I2FX24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_440308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700469.1">
        <property type="nucleotide sequence ID" value="XM_024850044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX24"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX24"/>
    <dbReference type="GeneID" id="36557743"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440308"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="11">
        <location>
            <begin position="426"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="682"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB45167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="873" mass="99106" checksum="67D026A4C5C643F4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXA3</accession>
    <name>A0A2I2FXA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_277512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700549.1">
        <property type="nucleotide sequence ID" value="XM_024843170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXA3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXA3"/>
    <dbReference type="GeneID" id="36550869"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_277512"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF152">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="520" mass="59524" checksum="7D47F232BEAD456C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYC8</accession>
    <name>A0A2I2FYC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative vacuolar ABC heavy metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_365051</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700946.1">
        <property type="nucleotide sequence ID" value="XM_024844682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYC8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYC8"/>
    <dbReference type="GeneID" id="36552382"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365051"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000050">
        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="311"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="631"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="884"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="887"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB45644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="931" mass="103643" checksum="6949A18E942C6CBC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYF2</accession>
    <name>A0A2I2FYF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-ER retention receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_449314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700967.1">
        <property type="nucleotide sequence ID" value="XM_024851035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYF2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYF2"/>
    <dbReference type="GeneID" id="36558734"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449314"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB45665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38871" checksum="6478F85FB4CE5D86" modified="2018-02-28" version="1">MNLNVFRLLADLAHISSKCILIWAIHRNKSAEGVSLLTQILYAMVFVFRYLDLIRPHNWKEPYLVFFKLFYIASSFYIIYIMMRVFPRTRERERAWKLALGSIAVALVLAPILNLIFYGEYPANHVFTEICWNFSIVLESVCVLPQLLLLRQTTVPTVINSFYLLTLGSYRAFYILNWLVRGLGPDHTWDRIADVFGIIQTAFYIDFAWVYYTRQRVKLRNGGVVDSEDFRNSWLLNKVLTFRQRRSTDEEQHLRDEEADDAMDADGERPGNNRWGARGISISADDTLEEHHQPRSQGTHKGNNSEVDGFLEEEEDPAGNHGENVWTQSPTRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYF7</accession>
    <name>A0A2I2FYF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_363782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700966.1">
        <property type="nucleotide sequence ID" value="XM_024844606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYF7"/>
    <dbReference type="GeneID" id="36552306"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363782"/>
    <dbReference type="OrthoDB" id="5421421at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39245" checksum="8F71D10A492F7AF7" modified="2018-02-28" version="1">MYPQTPCGYTGPMSYGHGVSTPGEGMDNFYDMQSQWSGVDTSPYGGVNHPYTSSAAFQSSAILTPISLPDSSFAHARPSPVLSHHSQEYQYGMSEPIPHHHGLGITAPFPSDFPRTVTAGFGHPVDDSEYGFSEGGLSPQPPSAKRARRSPKYMPQGRETPVTILPHPEGLQRLEQERRQGHVEPHPHQRPRAPGRGRRDPQAEEEDAFVERLREQNLAWKVIREMFREKFNKDASEARLQMRMLRRRKERLARWDENDIQLLIKAREYWEHEKYELIAEKMREFGSRKSYSAQQCEAQLRYLDTQNRDRGNVPLPRMTDPQHARRRAMLKASRGTAANVTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYJ4</accession>
    <name>A0A2I2FYJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_439431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700999.1">
        <property type="nucleotide sequence ID" value="XM_024849830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYJ4"/>
    <dbReference type="GeneID" id="36557529"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439431"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="795"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="892" mass="98990" checksum="0CA5428D13C90F71" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYN5</accession>
    <name>A0A2I2FYN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">37S ribosomal protein Rsm22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_439470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701046.1">
        <property type="nucleotide sequence ID" value="XM_024849841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYN5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYN5"/>
    <dbReference type="GeneID" id="36557540"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439470"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="842"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="859" mass="96489" checksum="3DDE42D4EFCC8AE0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYX6</accession>
    <name>A0A2I2FYX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MACPF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_363984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701136.1">
        <property type="nucleotide sequence ID" value="XM_024844619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYX6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYX6"/>
    <dbReference type="GeneID" id="36552319"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363984"/>
    <dbReference type="OrthoDB" id="2562973at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054586">
        <property type="entry name" value="MACPF_1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22693">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF-like" evidence="2">
        <location>
            <begin position="239"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="672" mass="74435" checksum="C4E6567114A38444" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZI7</accession>
    <name>A0A2I2FZI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_439730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701343.1">
        <property type="nucleotide sequence ID" value="XM_024849906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZI7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZI7"/>
    <dbReference type="GeneID" id="36557605"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439730"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="31520" checksum="44BEB066DAA98B3F" modified="2018-02-28" version="1">MAPPPAHLPLGERLKALAQTLQFAWFAGHVTLLISVFRYFLSYLTFNYYSSTAQAAYRLAFVAAAATYGIVVYKGHIARGRLQGSAPSIVLKLAGDENVQYLGMALVWLYSRQVSLALLPFSVYSIFHVATYSRAHLIPTLQPPQGGAAPASPASPSSPKPAPKQSPLAETIGRFVKQYYDTSMDIVASLEMTLLFRLVVSVLTFSKGAFVLLFIYSAFFRARYSQSSFVQQAVRHFTARVDASVSHQSTPPAVRQGWESFKGIVRQAYESTDLGRLVGKADAKKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G067</accession>
    <name>A0A2I2G067_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UMTA methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_458355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701572.1">
        <property type="nucleotide sequence ID" value="XM_024851792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G067"/>
    <dbReference type="STRING" id="1392250.A0A2I2G067"/>
    <dbReference type="GeneID" id="36559491"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458355"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="304" mass="33840" checksum="A6308B8EB3FE2925" modified="2018-02-28" version="1">MNEPIADPPCTSSSIFPSTDGLGYTLQNNHRAAARLNLQQYLWHETLGYHIHPGVQIPAFSPVIADVATGTGLWMIQVAREVPSAQVDGLDIDMTQAPHPAWLPGAIGLRYWDIFSPVPPDLREKYDLVHVRLLVLVLSGVDPVPAIRNLLALLKPGGYLQWDELDCVHMKLKKADESLVAPALEEIQSMLYATGRHNWALELPRTLTDCGFEDAWIDYYDEAPELVRAFNDQHLMTIEEFAGKLAQLGQVETAREVYDLVKTGYEESVQGVALSVPRVVVVARKPMISSDQGVRSNRRPLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0A9</accession>
    <name>A0A2I2G0A9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_458375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701612.1">
        <property type="nucleotide sequence ID" value="XM_024851794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0A9"/>
    <dbReference type="GeneID" id="36559493"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458375"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="260" mass="29895" checksum="9505B5A225C782BE" modified="2018-02-28" version="1">MPPIIHLVRHAEGLHNLGHAYWALIDPLLTENGRDQCLRLRREFPSHDNVELVVASPLSRAIFTAVEGFQPTFDRIPARQLVLLPDLQEISDFPCDVGTEVEELKARVRDLKVPIDWSFVHEGWTSKSGRYKPVTEIIEDRARDIRCWLSKRPEKEIAVVTHGAFLHFLTEDWEDSYTHEGTGWTNAEYRTFTTKPKESSGMDDASLIETVESRRRRGKTDPVPAAKEQAQLYVRALREWERQGYLLSAEDRYGVSSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Y1</accession>
    <name>A0A2I2G0Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_511285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701842.1">
        <property type="nucleotide sequence ID" value="XM_024854871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Y1"/>
    <dbReference type="GeneID" id="36562577"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511285"/>
    <dbReference type="OrthoDB" id="4427631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014155995" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="107" mass="10674" checksum="156261CB68574549" modified="2018-02-28" version="1">MQFSRVLLCVVALVGTAIALPTPEAPTDDVSTAGYTGAGGVAILNGVDLPAQKRDDATTQGYTGAGGVSILNGVELPAEKRDDATTQGYTGAGGVAILNGVELPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1A9</accession>
    <name>A0A2I2G1A9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_218781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701962.1">
        <property type="nucleotide sequence ID" value="XM_024842848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1A9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1A9"/>
    <dbReference type="GeneID" id="36550547"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_218781"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013986368" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="387"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="543" mass="58306" checksum="06FBC1F6FCAE43C9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1B6</accession>
    <name>A0A2I2G1B6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_511359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701966.1">
        <property type="nucleotide sequence ID" value="XM_024854881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1B6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1B6"/>
    <dbReference type="GeneID" id="36562587"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511359"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="132" mass="14862" checksum="18BAC56F6DBAAC48" modified="2018-02-28" version="1">MAICITFGSHEFTSMLEGYEHVRAYCYNCQHWNGHCVTRWPWFTICFIPAIPLAFHKYKVLPHLSPPLGSILTAQQEVTCYTCRFTQDLRDRPDITPETRPPPGVPAGPAPPPQAYYPPQGGAPPPQGYGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1K3</accession>
    <name>A0A2I2G1K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative importin 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_412015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702054.1">
        <property type="nucleotide sequence ID" value="XM_024846919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1K3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1K3"/>
    <dbReference type="GeneID" id="36554618"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_412015"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117711" checksum="4F2565D3124EFD07" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G213</accession>
    <name>A0A2I2G213_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_511576</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702211.1">
        <property type="nucleotide sequence ID" value="XM_024854902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G213"/>
    <dbReference type="STRING" id="1392250.A0A2I2G213"/>
    <dbReference type="GeneID" id="36562608"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511576"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="117" mass="13368" checksum="A3D64C064D7CD065" modified="2018-02-28" version="1">MPLTFCPNCSNALTISRGEATSRHPLGANRFECRTCPYQYVLEQSWYEKTPMKQKEVEDVFGGKEEFANADSMATQCPAENCNGERAYFFQLQIRSADEPMTTFLKCTSCGARWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G246</accession>
    <name>A0A2I2G246_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_228266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702250.1">
        <property type="nucleotide sequence ID" value="XM_024842888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G246"/>
    <dbReference type="GeneID" id="36550587"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_228266"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="263" mass="29278" checksum="931476DFADDD9D6B" modified="2018-02-28" version="1">MELGCYLISVLRTAYRVFHLALWRLGFDLSSLPLSAYSVLLFSETDLESGGNFLFLFLFSFFFSFPEHQKNGHGIFKEYSRPEASTTFFFSDRMEKPAHPCGEAANQMAIRAGRTWLNSTSQDALAQPRWLACVCISRPGAWPLRGLVDQGSKPIHSDRRDWVVRPSLSPLSLHPSTSHTHHPAHTHTRKNFSLWRLAPTTCCSFGIPSPSLLGYPSLRFFVLGPGSLLVALNSSPPMLMCVDGGGIPTSRMAPVQRPFHPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G254</accession>
    <name>A0A2I2G254_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_438658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702256.1">
        <property type="nucleotide sequence ID" value="XM_024849653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G254"/>
    <dbReference type="STRING" id="1392250.A0A2I2G254"/>
    <dbReference type="GeneID" id="36557352"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438658"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014157400" evidence="7">
        <location>
            <begin position="18"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="221"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="427" mass="45205" checksum="E70D6DB5EEBEB551" modified="2018-02-28" version="1">MLFPSSLLLATAALAAASPSPNFPQTPLQFFSSSPSTADSLDEVINDSPFLSFHRDLVQIESISGNENRIGYFVADFLGAHNFSVVKQPVTGGDGQVRFNIFAHRTSSHPQVLLTSHIDTVPPFIPYSLDRIDSDSSSTATVRISGRGTVDAKGSVAAQVFAALEVLDEDPEAPLGLLFVVDEEVGGKGMRVFSESSLNPSPSAFHTVIFGEPTDLALVAGHKGMLGFELVATGHAAHSGYPWLGQSAISAILPALSRVDRLGDIPAAKGGLPASPKYGRTTVNIGRVEAGVAANVVPASGRADVAVRLAAGTPDEAREIVRRAVRDATDGSEAVYADFSTRSEGYPPQDLDTDVAGFEVTTVNYGTDVPNLQIHDRADGSRVRRYLYGPGSIHVAHGDNEAITVAELEEAVRGYRKLIEAALDRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2G9</accession>
    <name>A0A2I2G2G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_499163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702349.1">
        <property type="nucleotide sequence ID" value="XM_024854141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2G9"/>
    <dbReference type="GeneID" id="36561846"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_499163"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="12434" checksum="5B9C110D37882040" modified="2018-02-28" version="1" fragment="single">MGTTALPERNTGTTERQHRAGVYPDPRKVHFTTGPLRSYYPPPVIFEELNLFMKWESRIHISEAQCNACMLFVDVCMAMCLFPRCMDGRPMATQEWSTTYLPTILDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3S6</accession>
    <name>A0A2I2G3S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_447484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702830.1">
        <property type="nucleotide sequence ID" value="XM_024850879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3S6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3S6"/>
    <dbReference type="GeneID" id="36558578"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447484"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="195" mass="21870" checksum="CFDD09CA6DEEB08C" modified="2018-02-28" version="1">MDHVPGITYIEAPLTTLRCASWQEQAVSDLARLAVLLRGLPSRFTNAITQILEDLPMIFLPTYPLVLSHADLCEMNIIVNPEAGGINGIIDWADAKVLPFGMSLWGLRNMLGIMDSKGWHYHENAPRLEGLFWETFYQSVGMVFGDGKRAIQVAERAGLLLRYGFTWEDGVVERPVSEQDSSMRYLDAFLPGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4A4</accession>
    <name>A0A2I2G4A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sexual differentiation process protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_496608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703009.1">
        <property type="nucleotide sequence ID" value="XM_024854101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4A4"/>
    <dbReference type="GeneID" id="36561806"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_496608"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB47707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="770" mass="86174" checksum="A2664B30EEB0CE4E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4C4</accession>
    <name>A0A2I2G4C4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_465311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703029.1">
        <property type="nucleotide sequence ID" value="XM_024852313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4C4"/>
    <dbReference type="GeneID" id="36560011"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465311"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="778" mass="88678" checksum="DB30F72282C5B4AD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4E6</accession>
    <name>A0A2I2G4E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_476415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703041.1">
        <property type="nucleotide sequence ID" value="XM_024853347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4E6"/>
    <dbReference type="GeneID" id="36561045"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476415"/>
    <dbReference type="OrthoDB" id="4368674at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="259" mass="29445" checksum="A0090D49C91B3675" modified="2018-02-28" version="1">MIWKAMFEEPFFLHIVPYDWEKADRLITTRATAGPRSYLETTCYSFHQAPAHSDDPSLDAIESAHPSPHGALSWLRTCRLIYTEAKPLPKDKDISLHVCDIFTFVAAVDGRTPSLPLSQVRSMSFCMKMDVEDVFYAQNLPALQALTIFAHFECLPFQGNDRLGDGPEDPAPRLRRVDCPWIISYVRPYSLLQALTRTVSMGDVKLDLAGVRHNPWNRCPNVGDRCWCRGRSIDESSVPVEQIKLHLMAGIWKVSIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4F9</accession>
    <name>A0A2I2G4F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase family M20/M25/M40 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_328815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703066.1">
        <property type="nucleotide sequence ID" value="XM_024843356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4F9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4F9"/>
    <dbReference type="GeneID" id="36551056"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_328815"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="599" mass="65449" checksum="6DC3B4AE92DB2B21" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4H9</accession>
    <name>A0A2I2G4H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_426979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703065.1">
        <property type="nucleotide sequence ID" value="XM_024847749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4H9"/>
    <dbReference type="GeneID" id="36555448"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426979"/>
    <dbReference type="OrthoDB" id="2883672at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="365" mass="40363" checksum="1F106410E19D9FE8" modified="2018-02-28" version="1">MAQNNQIYQDLMRNNSEGRFLFNPAPFRKLRPGSLGYFDHTGTFIEITNILEPGRPQRDGFSAFRSPLATEPPRARDWKAKHSASVQSQHARVTGGLSAAGAGAPIDASAEVKNKREASGQAALITPCELVEERIDGPFTTVVKEWVLGNGKTLMGSVHREKIKTQGLWIVGVTYVTAECAMKLTAGSSREIDVGLDLAVTGIGKAGFGTGWSEKLDSENWEVHRATEEDQGLVVAFAGAKYEVRMFSGLKSTPLKETDITQTIAFPEPRVIRDENGNVTDVQLVDAQDIPSEESEFECECDMAGLSEDQIAAEKAYAKQQEDRKNVLKWELIEIAKMENGEEKRAVLNRLLGYDDAQYWLTMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5P9</accession>
    <name>A0A2I2G5P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_325498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703510.1">
        <property type="nucleotide sequence ID" value="XM_024843340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5P9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5P9"/>
    <dbReference type="GeneID" id="36551040"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_325498"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="127" mass="13742" checksum="2666CE046B981634" modified="2018-02-28" version="1" fragment="single">DENGQTPLFFAARYGHTAVAKLLLHHGAEVDAKDRYYRTPLSWASTWGHATVAKLLLQCGAKVDAKDMFCRTPLLLAAKHGHAAVIELLLHRGAKIDMKDKSGETALSCAATEGHEGVILLLLQRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6L7</accession>
    <name>A0A2I2G6L7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_212694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703823.1">
        <property type="nucleotide sequence ID" value="XM_024842822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6L7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6L7"/>
    <dbReference type="GeneID" id="36550521"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_212694"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF4">
        <property type="entry name" value="FUNGAL N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="486" mass="53848" checksum="A4E4A1BEC03BEEDC" modified="2018-02-28" version="1">MAAGLDAIGVAASIIQLADFGAQLSMKLYTFYHQVKNADERLKSLSSNVSLTCTVLKQLASNLEQDEQAQLYSHEAFDTARQVSADCDAIFKKIDSALDRFKDGLARSSLQRAAAKVGFVFMENDINILRSDLERLKTTMLLLLNVIMYAGQIRSRAESKTLKEQSDFIQALVAEKAASEIQFLTLNRVVENPTNKLFDDTDFRAGSVSDELKSYCSLVERILCEIGVIQSNLEPDQYGRVRDGILRLHSEEIVHCEQAHGWDVGQLLREGFAKFCHSSGDVNVFTPRVIYNNGAPSPMAKAAGYTLKCSTRPTSPFPAQKPRDKLLGRYSDNTLAGSGCALSSASASSEVPPELIPPFLPPLQGDEEESSTPLPSLKKALESTIPQARHDELPSDGNGLAEGNSVLLRHLEPNRPDIADFERDHPLVEHSRFSRKMNILRRFDQRHPGGNREISPRLEKAKSALSLLLEVEPRNEENKPALPFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6S4</accession>
    <name>A0A2I2G6S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad17-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_322243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703878.1">
        <property type="nucleotide sequence ID" value="XM_024843320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6S4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6S4"/>
    <dbReference type="GeneID" id="36551020"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_322243"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="392"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="724" mass="80265" checksum="B11736BFDEC29F4A" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7E9</accession>
    <name>A0A2I2G7E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynamin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_446602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704083.1">
        <property type="nucleotide sequence ID" value="XM_024850814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7E9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7E9"/>
    <dbReference type="GeneID" id="36558513"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446602"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="481"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="548" mass="62203" checksum="066BC014659F281F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7I3</accession>
    <name>A0A2I2G7I3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_509510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704144.1">
        <property type="nucleotide sequence ID" value="XM_024854683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7I3"/>
    <dbReference type="GeneID" id="36562389"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509510"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="66" mass="7333" checksum="B18F5923C373F863" modified="2018-02-28" version="1">MGLGENTHIHLPSGISVLPTPFSLSPTFGLLVLLVLPLVFSAIHRGLLIWKRMPSVVYELTMWFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7L8</accession>
    <name>A0A2I2G7L8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_407608</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704178.1">
        <property type="nucleotide sequence ID" value="XM_024846691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7L8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7L8"/>
    <dbReference type="GeneID" id="36554390"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407608"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB48876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="363" mass="38448" checksum="C10F28CAC2E0EE56" modified="2018-02-28" version="1">MPAYNIVVFGGDHCGPEVTAEAIKVLRAVEKKRDVTFNLQDHLLGGASIDATGSPLTDEALNAAKNADAVLLGAIGGPKWGTGAVRPEQGILKLRKEMATFGNLRPCNFAAPSLVESSPLRADICRGVDFNIIRELTGGIYFGERKEDDGSGFALDTEPYSRPEIERIIRLAAHLALQHDPPLPVWSLDKANVLATSRLWRKVVTEVMANEFPQLKIEHQLIDSAAMIMVKNPRQLNGIIVTSNLFGDIISDEASVIPGSLGLLPSASVSGIPDGKSKVNGIYEPIHGSAPDIAGKGIVNPVAAILSVSLMFQYSFGLLAEARAIEAAVSNVIESGVRTGDIGGKATTSEVGDAVAAELEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7T4</accession>
    <name>A0A2I2G7T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_464524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704249.1">
        <property type="nucleotide sequence ID" value="XM_024852255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7T4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7T4"/>
    <dbReference type="GeneID" id="36559953"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464524"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000052">
        <property type="entry name" value="F-box protein (Pof7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="545" mass="61273" checksum="2FB6B897E0E42864" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7W8</accession>
    <name>A0A2I2G7W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Putative thiamine biosynthetic bifunctional enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_358119</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704278.1">
        <property type="nucleotide sequence ID" value="XM_024844259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7W8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7W8"/>
    <dbReference type="GeneID" id="36551959"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358119"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000042">
        <property type="entry name" value="Probable thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="7"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB48976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="518" mass="54521" checksum="10CC33A46A3852F7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7X6</accession>
    <name>A0A2I2G7X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_358126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704280.1">
        <property type="nucleotide sequence ID" value="XM_024844260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7X6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7X6"/>
    <dbReference type="GeneID" id="36551960"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358126"/>
    <dbReference type="OrthoDB" id="5369841at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="59665" checksum="2BB378A29B87C8C9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8E5</accession>
    <name>A0A2I2G8E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_327924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704462.1">
        <property type="nucleotide sequence ID" value="XM_024843350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8E5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8E5"/>
    <dbReference type="GeneID" id="36551050"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_327924"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014131050" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="10"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="224" mass="24243" checksum="4AFC459F8EDC2A67" modified="2018-02-28" version="1" fragment="single">APSWFTSTLMARRLLALSTTGVVSTIFPDPAPDKSHTPASLAGQSVSLREYISDCDEQLPSDSGHGGNGDPTLLGLHVSTTFRNIAAGSNLSVSIDWWDHVNDTKPVFPGFPLSEAGLPRVTLFGYVEEFPTPVPAETQEALKSCYLQAHPDARVWLPGRPGSPHSSFWARMVVTEVYWIGGFGGLQQIGWMNVTEWAGIRRKGSLAGVGDGRGWQDVRLPGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8P3</accession>
    <name>A0A2I2G8P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_408337</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704553.1">
        <property type="nucleotide sequence ID" value="XM_024846725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8P3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8P3"/>
    <dbReference type="GeneID" id="36554424"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408337"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="860"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="253"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="398"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="663"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB49251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1190" mass="128345" checksum="25C96E80863CEC3E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8S1</accession>
    <name>A0A2I2G8S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_384015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704577.1">
        <property type="nucleotide sequence ID" value="XM_024845666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8S1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8S1"/>
    <dbReference type="GeneID" id="36553365"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384015"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38261" checksum="1712ED470FA74BF3" modified="2018-02-28" version="1">MGGWDVYCAICASNFKKRIVADSDDESKNTYSADVIGESDTTWLGKVHGLGFNRDASGDRKSFLTGSGRYSDYGILSLEPGDDPNVPAHSDEEMIDFVAYDDPDGNQQPVFPVHATCYQDILPRCFNDTKQKINGDVLYTLFEEIVASNRMNRLDLDYGEPKPTKGQYWESKKGEEVLVTNPVQIPQLPEYLGKAQTIATKTKESKPENPPSTVDIFDKLPSELRLEILNLLPTASALALKTASWTMLKAPLSWRQKLASDMPWLWEFRDLEVDMCRSGKLNSELSQVVSELNEKSRYSKDQTGYIPGLVNRRRIWGVCENLRSMYMDKLEAKKDSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G914</accession>
    <name>A0A2I2G914_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_436956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704679.1">
        <property type="nucleotide sequence ID" value="XM_024849259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G914"/>
    <dbReference type="STRING" id="1392250.A0A2I2G914"/>
    <dbReference type="GeneID" id="36556958"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436956"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="4">
        <location>
            <begin position="79"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="5">
        <location>
            <begin position="352"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="557" mass="61672" checksum="3B8EA687F6BAECE6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G984</accession>
    <name>A0A2I2G984_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC multidrug transporter atrF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_359036</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>voriconazole(in) + ATP + H2O = voriconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61912"/>
            <dbReference type="ChEBI" id="CHEBI:10023"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:61913"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704742.1">
        <property type="nucleotide sequence ID" value="XM_024844329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G984"/>
    <dbReference type="GeneID" id="36552029"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359036"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001650">
        <property type="entry name" value="ABC drug exporter AtrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="791"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1212"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1245"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1282"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1322"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1353"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1392"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1478"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1509"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="184"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="880"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB49440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1537" mass="171902" checksum="BCDE11FC512B75B2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9C0</accession>
    <name>A0A2I2G9C0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_408739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704760.1">
        <property type="nucleotide sequence ID" value="XM_024846744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9C0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9C0"/>
    <dbReference type="GeneID" id="36554443"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408739"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="346"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="700" mass="77149" checksum="5B287B5A2C5BDF13" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9G3</accession>
    <name>A0A2I2G9G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_357729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704821.1">
        <property type="nucleotide sequence ID" value="XM_024844237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9G3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9G3"/>
    <dbReference type="GeneID" id="36551937"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357729"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nuclease activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="370" mass="42462" checksum="4FD939F8CAC06EBC" modified="2018-02-28" version="1">MDRKVFDIQPIGRFYGSSTSIRRPREIACFSYDDEHQFHLGEPSLRYYYPPRLPADLNRGFESFQKLDDSADEHLDALLGTILAVEKDTGKKCEADVITWRGMMTKILTAPFDTMNGWEMNATCFQVNAPLFIEENNAYKNHQKRLQHTQRMPPGMPSQEMMAYWGYKFETLSLLDQPWDATPRDKIESREELIVNNNAQYCSVVRTGIGSARLVIGGEVDAVWDSKPDRKEDPINWVELKTSAEIKNDRDMIKYERKLLKFWAQSFLLGVPKIIVGFRDQQGIVHRLEELDTASLPGKVKKMGKGTWDGNICINFAAAFLDWLKSTICEEGTWRIRKLEKSSVIEVFKTEESGTGDILSSSFSNWRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9I5</accession>
    <name>A0A2I2G9I5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcriptional repressor TupA/RocA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_437109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704830.1">
        <property type="nucleotide sequence ID" value="XM_024849288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9I5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9I5"/>
    <dbReference type="GeneID" id="36556987"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437109"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000030">
        <property type="entry name" value="Putative transcriptional repressor TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="405"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="546"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="585" mass="63752" checksum="A0451FF28F40608D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9R2</accession>
    <name>A0A2I2G9R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_356820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704916.1">
        <property type="nucleotide sequence ID" value="XM_024844178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9R2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9R2"/>
    <dbReference type="GeneID" id="36551878"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356820"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="406" mass="45662" checksum="0629AF9CC7D7358D" modified="2018-02-28" version="1">MALRRPHRKSRHGCSACKRRRVKCDETRPVCTNCSKRSTECEYDSTSSFLWANEPPKPAPRSNVSVSEGSQPPESTLLTANSFGVLGRLGGGGDRPRQTTDLNLSDLELMMQWCNSTYQSLTRARQTEYIWRCCVPEEALSHPFLMHGILALSALHLARTKSDHRGPVYLDTAVGHQNRALAFFRDRLSDINESNAKAMFAFASVVVMYALAFPHPPEADNDPWTCVDDLTQVFVLARGVHEVLRQATPSIVGSDWEIVLVLGEYDKSPPDDARAVLDRLHEANSQCGEQDSTHDTEVYRHTIENLGDMIAALSSGLITVTIACRWAIKCKPAYVDLIRDHTPLALVILAHYCAVLHSMREVWYVGEWSLRVPKAIWQILDDRWKPLARWPMETVYGESFPVDETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA21</accession>
    <name>A0A2I2GA21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_447332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705031.1">
        <property type="nucleotide sequence ID" value="XM_024850866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA21"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA21"/>
    <dbReference type="GeneID" id="36558565"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447332"/>
    <dbReference type="OrthoDB" id="5372703at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="156"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="341" mass="37332" checksum="A2DC8908836CF3CD" modified="2018-02-28" version="1">MASGLNTSLPPPSTSSLSRSRSSSPQKPSESTYRMRTLLRAGIYVDVDVPEEVKDQINIALQTPPTDAATLERLVSKLQHVSMELTAAQAGETEWTDLLYEIVKGLKPINLLVARNRDWRPDIKPRVHQPSVPQKRLCDTSGAVDSSVKTSAQAPMTPFYLKNPRPDISVGISDRALANILQSRQVRNAKYLLNDLQETRDLISDPGVNPLSLRFPFFLVEAKSGATGSNLYQAQNQAAVGGASAIEILKGLYKACDSPVLNTAPPSGVNTAHCWNETDGSYCMANIDMWRTTRESRASDFVSKISSILNWGSGTFQTTILEKLSFFSAQDSPSTFQPELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA39</accession>
    <name>A0A2I2GA39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_384940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705041.1">
        <property type="nucleotide sequence ID" value="XM_024845700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA39"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA39"/>
    <dbReference type="GeneID" id="36553399"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384940"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="343" mass="37937" checksum="8C0B27BDC3C0522B" modified="2018-02-28" version="1">MQYRFLGKTGLKVSALSFGSWVTVGGQVGYESARDCVLEAWNHGVNYFDTAEAYASGECERVFGQIIKDLNFKRSDLVISTKLFWGGPGPNDTGLSKKHLVEGMKASLDRLGLDYVDIVMAHRPDPLTPMEEIVRGFTHIVNSGQALYWGTSEWNAHDIERAHHMAAVHHLIPSSCDQPQYNAFWRERVEKELLAVIRNYGYGLTIWSPLDNGVLTGKYNEGIPSDSRFAAATVTGSTKQDMVNFGKALDTPEGQSKLKRVQELKKVADQLGCTTAQLALAWCLTNESVSTVITGASRPQQVVENMKAVAVYTQLKENAEVRANIEGILGNTPVQPRLFGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA47</accession>
    <name>A0A2I2GA47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">CFEM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_409332</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705054.1">
        <property type="nucleotide sequence ID" value="XM_024846772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA47"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA47"/>
    <dbReference type="GeneID" id="36554471"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409332"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014162915" evidence="17">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="96"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB49752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="181" mass="18126" checksum="5D3BCCCD0BA98177" modified="2018-02-28" version="1">MRLAATVVVLGACAITRAQLSNIPQCSLKCLTSALGADGCSELTDFACHCQKTGLVEQVVPCVKQDCDVTDQQAVSKVVVSLCSGAGQPISIPPVDSAPASTAAPTTSSSFNSTTASGIERGPQTRLAASMTSTTGSTASSTVNTASPSSIPLSNRSSGIQSGAARVAGVSILLASMMFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBB1</accession>
    <name>A0A2I2GBB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="7">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_445538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705474.1">
        <property type="nucleotide sequence ID" value="XM_024850720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBB1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBB1"/>
    <dbReference type="GeneID" id="36558419"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445538"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="516" mass="57892" checksum="E016F1D97BED03D3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBQ6</accession>
    <name>A0A2I2GBQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_473877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705616.1">
        <property type="nucleotide sequence ID" value="XM_024853085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBQ6"/>
    <dbReference type="GeneID" id="36560783"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473877"/>
    <dbReference type="OrthoDB" id="4393585at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="236" mass="26243" checksum="0E5C25FFBC61E228" modified="2018-02-28" version="1">MSGLLYASGGRGLLRYFFLHGSHERTSFPDQVEVEANVVSFARDGRVISGDNNEPVSQRYCFFNGTMTDTDGQAQALVPARELVETLLKNISVPALVLVEVPTSAISVLGRSDLRICVGEERRYLACMMRVFAPRFTQAMSQRRDEYLPGDAQNLSKEIARDMGASIADTAAATTSSSEREEEEEEDLLSFLQLYRQRYLGKSVTGNLDILEACLVHVLKMPFELASSVEQGLIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD31</accession>
    <name>A0A2I2GD31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">P170DRAFT_446020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD31"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD31"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446020"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="88"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="354"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB50772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="428" mass="49561" checksum="FD934EC07D952831" modified="2018-02-28" version="1">MLCSSFSISQLAIPSVCVLIAFLAYTSQYFFAYFEPSPLRESELWRINIFALCIWICYYRSCTVDPGRIPKDWKPVDSKQLEADRVSGRQRWCRRCETLKPPRAHHCKTCRRCIPKMDHHCPWTSNCVSHFTFPHFVRFLFYAVVGMGYLESLLFEKASIVWASRNLPSYLGPSASQIAHLFILLVLNSLTVFMLFVLLLRTMWSLAFNTTTIESWEIERHETLVRRARHFRGYLSGPGGTSIRIKKQEFPYDIGIWANIRAGMGGSRNVISWFWPLARTPARTTGLEYEVNGFEEPDVSWPPPDPDRIPIPSKQHLSSGISNAGNYERDEVEAFNRRKAEDLKRSRENLGIQRRRRFHNRLDKTKESPSKADESSDDIEDSEDGEEGWRNAEGERLGDFGVDEDAEFYDEEDIPLGVLLRQRAQKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD41</accession>
    <name>A0A2I2GD41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_355574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706116.1">
        <property type="nucleotide sequence ID" value="XM_024844096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD41"/>
    <dbReference type="GeneID" id="36551796"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355574"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="413" mass="45039" checksum="F510DE0A011CE0A6" modified="2018-02-28" version="1">MYDIVLLGATGYTGSLCATFIVENFPSTLKWCIAGRSATRLEKLVKDLTAQSPDRLQPAIETVEINTTSLEPLVKSAKVIINGIGPYHKLSTPVVDVCARVGTHYVDFTTETLWIRDMIEKYHKLAQDSGAIIIPGISPSGVSDILAWLLVKKIRETFGQNVSEIVCSGKLDIKAMTGGSLTTVLDVFSTYGTSWFLCPSPSILSPKPQVSPRTIPKEPLVTRLFGYRHSPELGHLTTSFNGSGNEAIVYRSASQNPNLYGASFQFKEYLPAPGVFGAILIHFLTKLLVVFLSISPIRALIKALIAGKMDLNPDITQLRSKESVEFHAVGKVQDSSDFRAWASFTRKGALYEFAALMSCVGAGVLLEKHSKSGKSEEKNDRLKGVVTPSALGMKFVERVRDAGIEVNVGLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDC0</accession>
    <name>A0A2I2GDC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_406336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706196.1">
        <property type="nucleotide sequence ID" value="XM_024846626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDC0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDC0"/>
    <dbReference type="GeneID" id="36554325"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406336"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013988862" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="19"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="616" mass="65385" checksum="F277A25EC3E453CE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GER8</accession>
    <name>A0A2I2GER8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_436389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706664.1">
        <property type="nucleotide sequence ID" value="XM_024849145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GER8"/>
    <dbReference type="GeneID" id="36556844"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436389"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB51362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="472" mass="51413" checksum="FC782723DCE8B2BC" modified="2018-02-28" version="1">MLFGYDTGIISAVLVYIDDALNNRTLTHSEKEMITSLCSGGAFFGAIAAGLMADKFGRKTCIYLGCALFTVGAVLQGAAYTIAQMAVGRFVVGLGVGSAAMMVPLYVAELAPAKARGRLIGLNNISITLGQVISYALGAAFASVPHGWRYMVGLGGVPSVLLACMLPWCPESPRHLIYHGRHEEARLVLYRIYRQASEAQIDFLAASIASACDDARRNNENESRWNKVKQLHTVPANLRALFSACGLMVISQMSGFNTLMYYSSTLFAMVGFNNPTAVGLVVAAPNLVMTFLNMILVDRLGRRRLLLCTVWGMSAGLIAVAVAFRFLPVDTESLEVPESSSASGPAIAVLVFVLWFVIFYGLSVGNTAWMSADFFPLEVRAVGTMWLTCSNWASNVIVSSTFLSMMHSMTPSGTFGFYAAICGLGYMWIYFFYPEVSGLPLEEIRQVFENGYGSKMRRRRGGNIAQEQRQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEX5</accession>
    <name>A0A2I2GEX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF924-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_474919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706679.1">
        <property type="nucleotide sequence ID" value="XM_024853198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEX5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEX5"/>
    <dbReference type="GeneID" id="36560896"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474919"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="173" mass="20040" checksum="7F1E48BCD641CF58" modified="2018-02-28" version="1">MPAKSYSDVLDFWFGPGSSPDYLKAKSFWYGSPADDAFVRSHLGDSYQAAKDGQLDAWTREGTGDGALALILLLDQVPRNVFRDTPQAYATDSKAVEVARYAVDQGWDRDRPAIQRRYMYSPFNHSEYLRDQEMSLRLFTDLGDSYHLHWARNFYEQIKRDGRFTHRDKILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFD7</accession>
    <name>A0A2I2GFD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_320658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706897.1">
        <property type="nucleotide sequence ID" value="XM_024843310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFD7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFD7"/>
    <dbReference type="GeneID" id="36551010"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_320658"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="482" mass="54409" checksum="B8A5BC262B32D8C3" modified="2018-02-28" version="1" fragment="single">MLLDSLYPLITYEIVESSDRIGGRAFTYWFPRDAISAWVWGEYYDVGAMRFPDVCLLYLVFRLFRHLDITEDNGLLIPYYLQGQNCPQRYNGISYVPRPDGPKDPFHFSVSNHGLVPDATVNEGTETILDDAFGYYKHQLRRNFEQGLHALMRVDQFTTRDYIRQVMNYDFYSVQYLETTSSATGRYEQAFTESVLDSFVFDFPDSRPTSWFCIKGGASIITDKLTDRIRHKPLLQTRVTAIEHNPHSASPMTLKLTTPDHPDHPDHPDLHTKSYDAVFATPTLPCLQRIDLSRAGLSRAQTDAIRAIHYDSSTKVAVEFASPWWISLCGISRGGYAATDLPLRTCIYPSYVTEDIRPATLLCSYTFARDAQRIAPLTQDPSQLKSLVLHDLALLHYQSAGLSFAEIKALLAREFMAMHAYDWARDPNASGAFALYGPGQFANYYPELVSPAAGGRLFLVGEACSAHHAWIAGSLDSAYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGD8</accession>
    <name>A0A2I2GGD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone acetyltransferase type B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_433836</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707238.1">
        <property type="nucleotide sequence ID" value="XM_024848587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGD8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGD8"/>
    <dbReference type="GeneID" id="36556286"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433836"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000313">
        <property type="entry name" value="Chromatin assembly factor 1 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="14">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="282"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="326"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="436" mass="48976" checksum="E048590B5D2F6C2F" modified="2018-02-28" version="1">MEPYEDGFIEEQEEQEEERTEEKIVNEEYKTWKKNAPFLYDMILSTALEWPTLTTQWLPDKQEVPDKPYSTHRLLIGTHTSSDAQNYLQVAHVQLPNPTTPNPDDYDEERGEIGGYGGSSKKAPMEIKFNIVQKIDHKGEVNKARYQPQNPNVIATMCTDGRVMIWDRSKHPSLPTGTVNPQMELLGHTKEGFGLSWSPHATGHLVTGSEDKTVRLWDLTTFTKGNKALKPSRTYTHHSSIVNDVQYHPLHSSLIGTVSDDITLQILDIREAETTRAAASAEGQHRDAINAVAFNPAAETVLATGSADKTIGLWDLRNLKTKLHALECHNDSVTSISWHPFEEAVLASASYDRKIMFWDLSRAGEEQTPDDAQDGPPELLFMHGGHTNRISDFSWNLNDPWALCSAAEDNLLQVWKVSDAIVGKDLEDVPTEEIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGM3</accession>
    <name>A0A2I2GGM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_401781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707289.1">
        <property type="nucleotide sequence ID" value="XM_024846388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGM3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGM3"/>
    <dbReference type="GeneID" id="36554087"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401781"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="396"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="561" mass="62416" checksum="5AB81ED65CB06572" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH29</accession>
    <name>A0A2I2GH29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_444228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707486.1">
        <property type="nucleotide sequence ID" value="XM_024850613.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GH29"/>
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        </source>
    </evidence>
    <sequence length="2077" mass="227804" checksum="E010CB03B6C0C5B3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH72</accession>
    <name>A0A2I2GH72_9EURO</name>
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        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:fungal-type vacuole"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="16"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PLB52231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="471" mass="52510" checksum="5436F81A1850B558" modified="2018-02-28" version="1">MRFFNLAWLVPAVLAIPHSDRANTVSTVKRDGITYNVFEHRATGSKLEFVKNSGICETTPGVNQYSGYLSVGENMNMWFWFFESRNDPKKAPLAAWFNGGPGCSSMIGLFQEHGPCHFVDGEKKPSLNEHSWNNYANMLYIDQPIGVGFSYGTNNVTSTVTAAPYVWKLLQAFYDQFPEYESRDFGLFTESYGGHYGPEFASYIQEQNKAIESGSVEGQKVDLVALGINNGWFDTSIQQQSYIDFAYNNSYRSLISEKQRDGYLQTLKEVCLPAVEKCTKTGTNDACREASSTCYSTVEGPIMGADDFDVYDVRRGSDDPEPPSTYSDYLADEEVKKAIGARSKYSECANAASAKFSTTGDNPRSFLSALSEVVQSGISVLVWAGDADWICNWIGNYDVANAVEFDGQDEFKGKSLKPYTVNGTEKGTFKTVDNFSFLRVYEAGHEVPYYQPEVSFQAFKQTLQKKPISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH88</accession>
    <name>A0A2I2GH88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_507091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707553.1">
        <property type="nucleotide sequence ID" value="XM_024854446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH88"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH88"/>
    <dbReference type="GeneID" id="36562152"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507091"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="55"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="129"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="344" mass="37388" checksum="737CAD805BF58500" modified="2018-02-28" version="1">MSPTRLLQKPRVVALGTPKYIPSSYLTEFAKSYNYSVLEAYTREATKTLLPLTIEQDGPIDALIIRMGTPPYEPFDADLLSSLAPDCKIITSASAGYNEFDVEWMASQGIWFCNTVDAVAEATADMALFLILAVLRNTTNAERSARLGSWRVPAGEGLVPGRDPSGLTLGIVGLGAIGKYLAKKAAVFNLRVIYHNRTQLSAKEEAAYGVRYCATLHELLAASDIVSVNCPLNASTTGLIGAAEFAAMKDGAFLVNTARGPIVDEQSLIEALESGKIARAGLDVFENEPRINPYFQSSDKVIIQPHLGGLTDMAFQRAEMECFENIRAFFEKGEPNSPVKMIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHH9</accession>
    <name>A0A2I2GHH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_472232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707631.1">
        <property type="nucleotide sequence ID" value="XM_024852926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHH9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHH9"/>
    <dbReference type="GeneID" id="36560624"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472232"/>
    <dbReference type="OrthoDB" id="3650366at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="39372" checksum="C4535B8B9539FFDE" modified="2018-02-28" version="1">MASDQPPARLYFFTYPRTGSNLLTHLLALDDQPNVQRQNPPEPYGMRFFLPLVLLKSKSRHLGTHVQALPQDQREEQERCVKECYGRLLDHIRNAEREGKMVCFKDHAHYIVEPVAEARLLYGDDSVTDQIPWTLRGPNELDQTDTDRSDLNDTLFSDDFLKTWKPAFLIRHPAAAFPSYYRALSKVSGPEFVQSDQGWKAYQKAMSLRWVYKLYNFYVQHFSKCRDDQASWPVVIEADDIINQPEILIKLCEITGLDSSRIRLTWEKSTSELPGVQVFHGTLLESTKIDTSKAVGDVDLEKESAKWQGEFGEHIGRRIEAYVREAMPDYLFLKSKRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHJ5</accession>
    <name>A0A2I2GHJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative zinc-binding oxidoreductase ToxD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_423228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707646.1">
        <property type="nucleotide sequence ID" value="XM_024847490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHJ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHJ5"/>
    <dbReference type="GeneID" id="36555189"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423228"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="14"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="348" mass="37536" checksum="9F07A9FA30531EF6" modified="2018-02-28" version="1">MATQKAVVITEPKKADLVPNHPVPTLRDDYILIKTVAVALNPTDWKHVAFLAPPGPIVGCDYAGTVEAVGKAVTKDLKKGDRVLGFVHGSNAVNHEDGTFAEYITAKGDIQVKIPDNLSFEEASTLGVGVTTVGQGLYQSLKLAWPTQPTTQKEPVLIYGGSSATGTLAIQFAKLSGYEVLTTCSPHNFDLVKSLGADAVFDYKDPNAAAEIRNYTNNGLKYVFDTISVQSSAKFCDEAISTEGGEYSALLVVKIERENVNDRWTLGYTSVGEAFMFGNIPFEAKPEDMEFAKKFWATARELLAQGKVKPHPIKVGGGGLRGVLEGMKAMQEDKVSGEKLVYRIADTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIM3</accession>
    <name>A0A2I2GIM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_434443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708022.1">
        <property type="nucleotide sequence ID" value="XM_024848717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIM3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIM3"/>
    <dbReference type="GeneID" id="36556416"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434443"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="144"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="271" mass="28922" checksum="57983A7F94C9C263" modified="2018-02-28" version="1">MASQPDFVRAMTNRSVRTVRLELEFLADASVITPQQLSSILSQLPTEDARQVSAPRQAPRQHQSPPVVAPSPIQAPAPIPAPAPIPAPAPIPAPVQTQPPPAPYSPPTNQFANTSLNEKATYQQPPTPQYNPTPPPPAYPQVPPVLSIASALYAYTPTDPGDLALQPNDRVQVLEHMNADWWRGRNERTNLEGIFPRSYVNVIQDKGVASPPPSGYGNMPLEVSQGGSAADPEGKNGKFEQHGKKFGKKLGNAAIFGAGATVGSNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ76</accession>
    <name>A0A2I2GJ76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_379209</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708232.1">
        <property type="nucleotide sequence ID" value="XM_024845477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ76"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ76"/>
    <dbReference type="GeneID" id="36553176"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379209"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="128"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="339"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB52930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="527" mass="57642" checksum="313173F15A84C8AA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJK2</accession>
    <name>A0A2I2GJK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_379450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708365.1">
        <property type="nucleotide sequence ID" value="XM_024845485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJK2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJK2"/>
    <dbReference type="GeneID" id="36553184"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379450"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="299"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="855"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1013" mass="109865" checksum="CCE40E9B538FD25E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJK3</accession>
    <name>A0A2I2GJK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_348437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708358.1">
        <property type="nucleotide sequence ID" value="XM_024843676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJK3"/>
    <dbReference type="GeneID" id="36551376"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348437"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21526" checksum="8D913ED65421BBCB" modified="2018-02-28" version="1">MPPRRRPPPAGARTELPPLKIVRKILLLQLAYYASATALILFTTLVYGTAFSLNLVLSWDALRGDTTLGWMLGLVWMLNSGIGAIFLLVLVARSKLIPDFALTLHFLHLIATTLYTHSLPGNWLWWGLQCASAALMTFVGMWACQWRELRPISFGGISGKATGNGASESAAAGSSSRGRQDGDEYEMAEMKGTGEQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJT9</accession>
    <name>A0A2I2GJT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_507846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708446.1">
        <property type="nucleotide sequence ID" value="XM_024854514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJT9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJT9"/>
    <dbReference type="GeneID" id="36562220"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507846"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="354" mass="38950" checksum="B2874D0046D087D6" modified="2018-02-28" version="1">MLSSSLRRAAWAPIVPISGISRSSSQGLNASSNGLIGATQQVRQRRYSSSSSKPSDGSRKVDASSQTPAKGVNSAEKREGKASKRRGKENNGRNGSKSNQHTAFSRLPSVPSTQHLQPHDVHIASFFSIHRPISVSTTVPPTSSSEAFDAIFTAKRSSKHEADDVMFTLSSTVDSMENAALHAEHEGPVSSFEMDGGHPDGMNMADVKISIEEHTKRLRPFHPPPPPVPFDESAKDIAVTESEGLMSSRETSSYSTVLTIHESTHADGRKTYEAHTGPFVRNSDEMDAPGATDNDAIIDVPANNSETTYIERVRSNRTMHALSTKRRRRLKMKKHKFKKLLRRTRTLRRKLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL82</accession>
    <name>A0A2I2GL82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polysaccharide export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_371759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708932.1">
        <property type="nucleotide sequence ID" value="XM_024845182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL82"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL82"/>
    <dbReference type="GeneID" id="36552882"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371759"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="47626" checksum="59F7D455828AEE52" modified="2018-02-28" version="1">MRLISRPGPDPLRRSRLYRRVLYTLLVLFLIWTAAEITAVQRRLDPLVSVDERILRKSHLRTERVFIVGIHWNNEWILRNYWNQAVTDLAQTLGPENVFLSIYESGSYDNTKGALVELDRMLDPLGVPRNITLSEVTHQDEIVQPSTDDGWLQTEQTGKELRRIPYLSRLRNLSLQPLVDLAKQGIHFDRVLFLNDVVFTTQDVLELLQTKDGRYAAACALDFSHPPAYYDTFALRDIQGHEPIMQTWPYFGSSASRQALKRMEPIPVASCWNGIVAMRASPFVARENPLRFRGIHDSLAREHLEGSECCLIHADNPLSSLSGVYLNPRVRVGYHGAAYDAVHPGEQWLTSWKIWAGLWSNRLRRWGSVNRSRRETQKRVVSWEREHGQEERGAFCLIDEMQVLRPWGWAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLP0</accession>
    <name>A0A2I2GLP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_460141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709089.1">
        <property type="nucleotide sequence ID" value="XM_024851916.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GLP0"/>
    <dbReference type="GeneID" id="36559614"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460141"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001577">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001751">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1067"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1091"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="279"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="636"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1265"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="842"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB53787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1481" mass="165184" checksum="5625FB8E6B74B047" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMY5</accession>
    <name>A0A2I2GMY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_460445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709553.1">
        <property type="nucleotide sequence ID" value="XM_024851941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMY5"/>
    <dbReference type="GeneID" id="36559639"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460445"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="419" mass="45885" checksum="5E56211F244F9EEC" modified="2018-02-28" version="1">MLALRDQENLVHAHQTVAASKPLNQGGKQLQPKTPGARAPKTPFKVPLNDENDPLAFGKKTVKGTGKQKENAKPSVKDAFVTPLADPRQRAPLGMKTTNAKAKGLQTPAPPAGTVKPERTTKRGSTQRAKKFTPLVEQSQSKVQDKPAQDDVPDIEYMPPKPKELPDIPDDITYDTTFPQFKPKNFALGLESVYGDNEIGNDGLTKRERKLQEDSVACDKMMDEMILEQIENIAFEEADRTKSHDESLPKETSRAHRVRAPTTRIKQTSNISTVRARDAAAALSGTDRSIPRTRQAVNPKVKPRVTSSLFSSRKPRAPTNPSSMRHTAAISSSRTTVGYTKGRDVSSRLHGKPSDAVAPPVAKGILSPETYVQPVEVPSDTELDAGFGEQETDVVPGDVENVLPTYEEDEESQNFQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN73</accession>
    <name>A0A2I2GN73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat protein nuc-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_14148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709626.1">
        <property type="nucleotide sequence ID" value="XM_024842471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN73"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN73"/>
    <dbReference type="GeneID" id="36550168"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_14148"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF23">
        <property type="entry name" value="DEPENDENT KINASE INHIBITOR PHO81, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="714"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115104" checksum="EDA2947C08FA5B5D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNA1</accession>
    <name>A0A2I2GNA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_505132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709664.1">
        <property type="nucleotide sequence ID" value="XM_024854261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNA1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNA1"/>
    <dbReference type="GeneID" id="36561967"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505132"/>
    <dbReference type="OrthoDB" id="5297881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="763" mass="83069" checksum="E52360E5AAAA2699" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNB1</accession>
    <name>A0A2I2GNB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DENN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_442472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709666.1">
        <property type="nucleotide sequence ID" value="XM_024850465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNB1"/>
    <dbReference type="GeneID" id="36558164"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442472"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="237"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="878"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="730"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1124" mass="124678" checksum="109F0BF72E9E91AB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP19</accession>
    <name>A0A2I2GP19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_470078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709923.1">
        <property type="nucleotide sequence ID" value="XM_024852706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP19"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP19"/>
    <dbReference type="GeneID" id="36560404"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470078"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07144">
        <property type="entry name" value="ALDH_ALD2-YMR170C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="502" mass="54089" checksum="E5168BD21421B8E4" modified="2018-02-28" version="1">MSDVALQLTAPNGHKYSQPIGLFINNEFVPSKSGEKFATINPSDESEITSVYAAGSEDVDLAVKAARKALKDPSWKSLPPTDRGNLMLKLADLIEQNRETLATIETWDNGKPYNVSLNDDLGEVLSTLRYYAGWADKIHGQTISTTPAKLAYTLRQPIGVVGQIIPWNFPLAMAAWKLGPALACGNTIVMKPAEQTPLSILYLATLIKEAGFPPGVINILNGFGRVAGSALVNHPDVDKVAFTGSTVTGREIMKMAASTMKNITLETGGKSPLVVFDDADLEQAAKWAHVGIMYNQGQVCTATSRILVHDSVYDKFVALFKEAVASTSKVGDPFADDTFQGPQVTKAQYDRVLSYIEAGKSEGATLVAGGEPFKNVGDGKGFFIAPTVFTNVKDNMRIYREEVFGPFVVIASFTTEDEAVTRANDTTYGLGAAVFTKDIERAHRVASDIEAGMVWINSSNDSDFRVPFGGVKQSGIGRELGEAGLEAYSQTKAVHVNMGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP87</accession>
    <name>A0A2I2GP87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_470140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709994.1">
        <property type="nucleotide sequence ID" value="XM_024852716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP87"/>
    <dbReference type="GeneID" id="36560414"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470140"/>
    <dbReference type="OrthoDB" id="4166960at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014168462" evidence="1">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="86" mass="9429" checksum="FA1CE577CB1E8712" modified="2018-02-28" version="1">MKTFLLALCLAPAALAAYLQVSVPVHIMDQCEQGNGYCGINLRDMGYDNLINYDDNALYYCDDVNSPDYIKKCGGSCQGPKAHCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPA2</accession>
    <name>A0A2I2GPA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline phytoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_505417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709995.1">
        <property type="nucleotide sequence ID" value="XM_024854283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPA2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPA2"/>
    <dbReference type="GeneID" id="36561989"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505417"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="270" mass="30610" checksum="E4AE12211B33D320" modified="2018-02-28" version="1">MVSSLVSPFWGPQTSYLNFCEEDYVVTRYVGEFINTLSSFVYVIYGIYGLLQLHRNGRTGSRSITYCGLIGVGICSGGYHMTLKYHTQMSDELSMHLLTTPLLYRILTFQTTPQYTSMVRVLLSLLFTIVMVVHMVMDEFLLHAVTFGLAVYLIATRTLKLIPQQIPDPVTRKNIQSIAIFGCFSFVFGYIVWLIDDWACQYLTSTRHFIGLPWAFLLELHGWWHVFTAIGGYIAVALIDMITSGEVDKNSTKRLAWPLPAVARFVGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPE8</accession>
    <name>A0A2I2GPE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_347254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710050.1">
        <property type="nucleotide sequence ID" value="XM_024843619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPE8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPE8"/>
    <dbReference type="GeneID" id="36551319"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347254"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="142" mass="15299" checksum="7176B578357947D8" modified="2018-02-28" version="1">MKILTYLCSRGAKVDAPNSLGDTPLHFAVIRGFPEAIRRLVELGAPRDCRNALGQTPLHAALAGDPAIIRLLVALGVDINAADFDGMTPLHEAMFEDSEAAALELIRLGADVHICNVDGVSPWDIAVYEDLEMIIAMCKSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPJ6</accession>
    <name>A0A2I2GPJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hspc200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_398564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710104.1">
        <property type="nucleotide sequence ID" value="XM_024846228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPJ6"/>
    <dbReference type="GeneID" id="36553927"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398564"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="32357" checksum="37765B4020183E55" modified="2018-02-28" version="1">MSTTSPKEEHQSGLPLVPCQTSPEIIQEMVAACAVGDFPRFKSTFDTWTCLNLDIHDLDSVMIQAVRQDQKDVVAELLQQGLQVHQDYALQAIRHRSKEVLNTLLQHGWNINNPTSALRPPALGCAVDDEEMTLWLLNHGADPNKQCSIDLTPLSYAVEEASLPTLRLLLDRGGDVHKGQLLHHAVERQTNIIEVLGMLLERGAPLNSKMYEKHYPSWRLYYFMGLRTPLHKAAELGKADVVRYLVDQGADVGIKDARDRSAMDWAALNNHQEIVELLHAVERRQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ22</accession>
    <name>A0A2I2GQ22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_432501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710276.1">
        <property type="nucleotide sequence ID" value="XM_024848276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ22"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ22"/>
    <dbReference type="GeneID" id="36555975"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432501"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="449" mass="49388" checksum="4CFF28D478EDBE67" modified="2018-02-28" version="1">MILFPRPFRPLAVPRLWLSSSIRSYHPQNYHTIMSSPQQQQQQQQQPRKQRPRPPKQESHRGPAKKEKRPQLTHFLCLPLVNSTSLPQLESSLAAFKAEIPRATTHQGQDQSAEPQPLIPDAAIRPVGTLHLTLGVMSLPSKERLDEAIGLLQSLDLVALVREAERIARVRAQGRGAREPALEAPGSDRSGDGSNEPGNRGDEGAPSPFTVSLESLHALPRARAATVLHAAPVDSTSRLYPFCELLRDKFLDAGFLQGEVQKDDAPQQTQQGGNSSANHPSELESRPLGDGVSSKQPAEEPSLLEEMPAEVTEGVAKNSDQPITPSPSKTASRKPKSRPLLLHATVVNTIYIKGRSRGAGGGKSQKNNRYSFDARDLLARYRDYHLDGQSEDGNTSTRGPFVWARDFPIESVCICEMGAKKLDPEGDESGLNARLREKYMAVAERKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ65</accession>
    <name>A0A2I2GQ65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_29426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710311.1">
        <property type="nucleotide sequence ID" value="XM_024843240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ65"/>
    <dbReference type="GeneID" id="36550940"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_29426"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="82" mass="9623" checksum="39684B8E5EC4AA1F" modified="2018-02-28" version="1">MHDLRVPGKRCGNRKKKRKEKKSYRARKEKNAAQDYVFFFLFFFFSFIFFLFQIALLVAPPDTACCISDAYGSWNLIGGRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQV1</accession>
    <name>A0A2I2GQV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_346767</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710561.1">
        <property type="nucleotide sequence ID" value="XM_024843584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQV1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQV1"/>
    <dbReference type="GeneID" id="36551284"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346767"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANTSNTHASEII"/>
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        <property type="entry name" value="GATASE"/>
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        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
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            <begin position="210"/>
            <end position="414"/>
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        <location>
            <begin position="238"/>
            <end position="244"/>
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        <ligand>
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            <dbReference type="ARBA" id="ARBA00004514"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022755"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022962"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00030464"/>
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            <dbReference type="ARBA" id="ARBA00031356"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB55259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="539" mass="59665" checksum="A8DD14D6D8063DA2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRK7</accession>
    <name>A0A2I2GRK7_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_470926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024852798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRK7"/>
    <dbReference type="GeneID" id="36560496"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470926"/>
    <dbReference type="OrthoDB" id="4755622at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="565" mass="62316" checksum="220791F235222596" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRS0</accession>
    <name>A0A2I2GRS0_9EURO</name>
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        <submittedName>
            <fullName evidence="8">DUF747-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_433096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710879.1">
        <property type="nucleotide sequence ID" value="XM_024848404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRS0"/>
    <dbReference type="GeneID" id="36556103"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433096"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="960"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121594" checksum="0B228203EC2BEA1B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS21</accession>
    <name>A0A2I2GS21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_47350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710972.1">
        <property type="nucleotide sequence ID" value="XM_024853048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS21"/>
    <dbReference type="GeneID" id="36560746"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_47350"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="191" mass="21448" checksum="5F18284715D43555" modified="2018-02-28" version="1">MPPRITIQMLSLSDHGLMFSCYYFLLPQEGRFCAVSRAMNMWQCVPLSSSPVSGDDRTRQVTKTKRYRRGVLRMTATKVLAAKSNAQFGFENKQWEIGCADSPSSEWPSHVVLQDEVKADTSVRHGGYRRGKREIISLPKPTGAISHDLKICLERAERPGKANIPKLSPLPSAKTGYVTCRRPNEETCSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS37</accession>
    <name>A0A2I2GS37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha-1,3-glucanase/mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_461503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710993.1">
        <property type="nucleotide sequence ID" value="XM_024852042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS37"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS37"/>
    <dbReference type="GeneID" id="36559740"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461503"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014175407" evidence="1">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="489" mass="52834" checksum="F4536A3B2D503460" modified="2018-02-28" version="1">MKINNLLLAAASLLSSTVWALPGDTSLKERDAPSRLVFAHFMVGVVSNRKSAADYDDDMKRAKAMGIDAFALNAGDDDYTNDQLNYAYESAANNDMKVFISFDCNYWGTDRASDIGKKVADYAGKPGQLIVDDKPFVSTFLGDGLDVAALRSAAGQEIYFAPNFLASADVSNVDALFNWMAWPNNGHNKAPSDGNQLAVTDGDNAYTSALGGKDYIAPASPWFFTHFGAEVDYSKNFAFPSDTLWYDRWNQILDLGPRFVEIITWNDYGESHYIGPLSSPHTDDGNSKWANDMPHNGWLDLAKPYIAAFKAGATSVNEYITDDELVYWYRPNPRDTDCDATDTCMADANNDSGNYFKGRPNGWESMEDSVFVVSLLKSPATVQVTSGGNSKSFDAPAGAASFKVDMGVGKQQFSVSRDGQEVLSGTSLKEIINGCVCGLYNFNAYVGTLPAGDADALQPEALTSLTEGLKVDTCQATPSLAASVPAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSE5</accession>
    <name>A0A2I2GSE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">P170DRAFT_346152</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cell tip</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711085.1">
        <property type="nucleotide sequence ID" value="XM_024843551.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GSE5"/>
    <dbReference type="GeneID" id="36551251"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346152"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 20" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 20" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="933"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1205"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1600"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1627"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1655"/>
            <end position="1678"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="957"/>
            <end position="1016"/>
        </location>
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        <location>
            <begin position="1796"/>
            <end position="1851"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PLB55783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1863" mass="206983" checksum="DF899BA178F8067F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSK1</accession>
    <name>A0A2I2GSK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_506361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_024854388.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="36562094"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506361"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
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    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
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        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="NPHP3_N"/>
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        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="381"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1424" mass="161165" checksum="7FBF4B029257461E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSK2</accession>
    <name>A0A2I2GSK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_50889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711150.1">
        <property type="nucleotide sequence ID" value="XM_024854615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSK2"/>
    <dbReference type="GeneID" id="36562321"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_50889"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="70" mass="8611" checksum="F02BAF58702EA63E" modified="2018-02-28" version="1">MGRLLFFFFLFRGSNLNFGISLVWFKFWGCLLISFSFIFFFSLFLFPSYFILFYFILFFGFHFIIILDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRH2</accession>
    <name>A0A2I2FRH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxyphosphonoenolpyruvate phosphonomutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_441666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698508.1">
        <property type="nucleotide sequence ID" value="XM_024850371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRH2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRH2"/>
    <dbReference type="GeneID" id="36558070"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441666"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF16">
        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="264" mass="27292" checksum="E3F069691025B307" modified="2018-02-28" version="1">MSTQNDRAIYFRSLHRPGNPIVLSNIYDGATASYIAAHASTKAIATASYAIAASQGVADESLTLSQNLASVRTIASVVAATSPQLPLTVDAQDGYEDVAQTVREIIALGAVGCNIEDFDNRAGTLRSLPDAVARIRTAVQAAKDAGVPDFVINARTDILGPAGTGVIADAIQRGQAFLEAGACTVFVWGGPGGRGVSGAEVRELVAALGGRVNVKLNLAEGSLTVAELKQIGVARISLGPELWRAAMGAFRETADRLLAGVSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRH8</accession>
    <name>A0A2I2FRH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_419046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698519.1">
        <property type="nucleotide sequence ID" value="XM_024847259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRH8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRH8"/>
    <dbReference type="GeneID" id="36554958"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419046"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF7">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="341" mass="37336" checksum="5D507F7333A61549" modified="2018-02-28" version="1">MAPQKVFVTGATGYIGGDVFFDFNQAHPDWEYSVLTRSKEKGAQVSSKYPNARIVIGDLDSSDVIAEETKNADIVLHCADCDHVASAEAIAKGAAQHTPERPLWLIHTSGTGILTVEDFRTNTWGLYRTKEHDDWDGVDELLNLPDDSLHRNVDKIIIDAGKKNPDSVKVAIVCPPTIYGPGRGPGNQKSVQAYWLTAAVLKRKKGLLVGKGENIWHQVHVQDLSDVYLLLGDAAAAGGGKATWNDKGYYLAENGPFVWGDIQREVARVAHEKKLIPSSEVEPLPDAEVTALNQFGLYAWGSSSRGHSLRARKLLGWSPSRPSLKELIPEIVDIEARDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRW8</accession>
    <name>A0A2I2FRW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_468996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698676.1">
        <property type="nucleotide sequence ID" value="XM_024852580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRW8"/>
    <dbReference type="GeneID" id="36560278"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468996"/>
    <dbReference type="OrthoDB" id="4486482at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="290" mass="32982" checksum="D096A49ADE9E471A" modified="2018-02-28" version="1">MSATIHCKTLDLDEIIPRPNCIEREDEDVKRLVPLVFHDACFATDRTDSWPDDQAEFRNFFAVFFSFYDELREPSETSPSIVFKEREMITLPRKNWTAPSRGHRSAGFRGVQVSLMTTLMQTICYNLDGIQEQLPGVWFTYSPVKMRYFIGGKRYASTSDGGAVVGPFANPRPIIPHVSWYRGQSWSEFLADVMDIMLGKLASNLTFNSEGQEAFIVGIRGPCIYVIRGRFTASLVSRVHSKGCAENESFELQFTRGFNLRLKEDWLQATRALARLLRYIPGGKAVEHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS90</accession>
    <name>A0A2I2FS90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DCG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698796.1">
        <property type="nucleotide sequence ID" value="XM_024850202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS90"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS90"/>
    <dbReference type="GeneID" id="36557901"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440960"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12500:FF:000003">
        <property type="entry name" value="Hydantoin racemase (Dcg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="294" mass="31037" checksum="A3F08A0ED28031CB" modified="2018-02-28" version="1">MAPTTNRRFAILVINPNTSQHMTDTLNPIVENLNFTDVQFNYFTAPSESVTLADGRIIEGVPSINSGEDSAKSALHCMPFVEPLIPKYDAFLVACYSAHPLVGMLKKAITNLEDSASIGDAPGPAATRKCVTGIFEASVVTSLSLISSFHLIGDQGYGKAQANDTFGIISTGSVWKEELGKAVAEMLVHSEGANNPTRRFAGVETTGLTAVELHTTPAEEVKRRISEATEKLIKSTSDPLTAICMGCAGMAGMEEAVREGCVKAYGPKQGKQVRIVDGVVAGAGLLVTACKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSJ9</accession>
    <name>A0A2I2FSJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Auxiliary Activity family 9 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_450827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698912.1">
        <property type="nucleotide sequence ID" value="XM_024851147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSJ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSJ9"/>
    <dbReference type="GeneID" id="36558846"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450827"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014158877" description="Auxiliary Activity family 9 catalytic domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="381" mass="38715" checksum="92CF10C135E0F796" modified="2018-02-28" version="1">MSIAKIAGVVLGSAALVAGHGYVSGAVVDGKYYGGYIVTSYAYTDSPPDTIGWSTEATDLGFVDGSDYSNADIICHKSAKPGAISAEIAAGGKVELQWTEWPESHHGPVITYLANCNGDCSKVDKTSLEFFKIDEKGLVDDSDVPGTWASDELISNNNSWTVTVPDSIAAGNYVLRHEIIGLHSAGNKDGAQNYPQCFNLKVTGGGSDKPEGTLGTKLYTDSDPGILISIYSSLDSYEIPGPALYSGASSGSGSGSSGSASSSAAPSATAAPSTTAAAGGAGGAQTSTATAYQTSTAVASVTVTGTPAQQTKVQDAPSQTTAAASTETGSSDSSAPAPSGTSSSSLTEYFNSLSADQFLNLLSETFSWLVTDKKHARDVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSX3</accession>
    <name>A0A2I2FSX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699026.1">
        <property type="nucleotide sequence ID" value="XM_024850257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSX3"/>
    <dbReference type="GeneID" id="36557956"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441180"/>
    <dbReference type="OrthoDB" id="4507898at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="116" mass="12974" checksum="CFAE0D5E564F755D" modified="2018-02-28" version="1">MADNTVSIDGIDKVELTYALWQNSEVAFFFAQNNVRPPTLTKDELREIGPRNQWSFDYLKGRLIKCDLSGTVVNPEGYDRDYGLGAFRAVVDSLRTAEKPAEKPDEKECSPSAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSZ8</accession>
    <name>A0A2I2FSZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_369504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699051.1">
        <property type="nucleotide sequence ID" value="XM_024844910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSZ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSZ8"/>
    <dbReference type="GeneID" id="36552610"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369504"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="418" mass="47634" checksum="54B4CA32A2401D84" modified="2018-02-28" version="1">MGSTNGSCDSSLRYIAQSYNHADSQASAMRLILTLNPHWGGPDNKIEFVRFTDGITNTLLKIINRKPGLSDEQIDHEAVLMRAYGNHTEIIIDRERETKSHALLASYGLAPSLLARFQNGLLYRFIRGRPATHEDLVKPSIWRGVARRLAQWHAVLPISEAASATNGSADDHMPIMHRVDVEQQSKKDDIIPITPRQPPPNTWSVLQKWIRALPTTTDEQRQRRLSLQKELQRVVKEFDDGKGLGENGLVFAHCDLLCANVIAAPSKEPSSDEATTVHFIDYEYATPSPAAFDIANHFAEWAGYDCDYNMMPTQSMRRQFLTEYVKSYSHHRGLPESSQPDIVDQLYRDVDRYRGIPGLYWGIWALIQAQISQIDFDYASYAELRLGEYYAWRREAEGTRADAGEEMPLRERRWAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT80</accession>
    <name>A0A2I2FT80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_451003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699155.1">
        <property type="nucleotide sequence ID" value="XM_024851163.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FT80"/>
    <dbReference type="GeneID" id="36558862"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451003"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="888"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="762"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1160"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1250"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="895"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1318" mass="146640" checksum="EB28DB515833A9FB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT83</accession>
    <name>A0A2I2FT83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_393810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699126.1">
        <property type="nucleotide sequence ID" value="XM_024846032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT83"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT83"/>
    <dbReference type="GeneID" id="36553731"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393810"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="388" mass="43839" checksum="39A47CE26DAF6EB3" modified="2018-02-28" version="1">MSKTAKYLLVSLPTSITPSHHRDDALDAVSATVAPENGSVAPFPIPEFKIGTLDALVQQADELAKLETACQAVVVKVGDALKNILEGDEAQIDKMKTVNDKPADQYLRTFSWNKVKYRADKSLGELIDLLQKEAASIDNDIRTKYSQYNQVKGNLATLQRKQTGNLSTKSLASVVDPRKIVQDSEYIETHLVAVPAQQIKEFLKTYETVSPMVVPRSATLVAEDDEFTLYAVTTFRKHSVEFVHKARENKWIPRDFKYVEGGKEEERKEFERVGGDERKLWGETLRLGRTAWSEAVMVWIHVLVLRVFVETVLRYGLPLDFVCTIIRTPSSKQADKAKHNLDEKYSYLAGNAFGRDKKGRVKRDDPGEMQGEGAGEYTAYVYYDFEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT90</accession>
    <name>A0A2I2FT90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CLF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor clf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_514171</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699165.1">
        <property type="nucleotide sequence ID" value="XM_024855183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT90"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT90"/>
    <dbReference type="GeneID" id="36562889"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514171"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="308"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB43863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="672" mass="81380" checksum="2B937C1960DF44C5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTN9</accession>
    <name>A0A2I2FTN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_451116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699307.1">
        <property type="nucleotide sequence ID" value="XM_024851169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTN9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTN9"/>
    <dbReference type="GeneID" id="36558868"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451116"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="28"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB44005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="385" mass="41347" checksum="005C8C3FC87ABFE3" modified="2018-02-28" version="1">MSSQAPHPTLLIPGPIEFDDAVLQSMSHYAESHVGPGFVKTFGETLSLVRKLFQSTSPAAQPFVISGSGTLGWDIVASSLIEKGENALVLHTGYFADSFASCLETYGANATQLKAPVGDRPSFEQIEQALQEKPYKVITITHVDTSTGVLSDIKRVAEIVRRVSPETLVVVDGVCSVGCEEIAFDAWDIDVVLTASQKAIGCPPGLSILMLSGRALDRFKTRQTPPSSYYASLGNWLPIMQNYENFKPSYFATPPTQLVHALHTTLSQITARPMAERFAVHAQASDRVKAAVAELGLTQLAANPENQAHAMTAIWLPEGLAPPDVLPGLLKRGVIFAAGLHKEVATKYIRFGHMGVSVTSGRQDVDNAIAALKEALTEAKQAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTW4</accession>
    <name>A0A2I2FTW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_450302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699390.1">
        <property type="nucleotide sequence ID" value="XM_024851111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTW4"/>
    <dbReference type="GeneID" id="36558810"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450302"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="350" mass="39915" checksum="E81F0AF95FC9C8B1" modified="2018-02-28" version="1">MIGPNAQTPAVHYGSLFIFFGYLSLAIFLVFICFRPIYLRYQARQHQNDWAPPYRHRHLALFVFLAGLSLGTTWYHMIRLFAHSYNSWAASPDGLPYWGGETSLITRLGLWLHKTYVFQEAWETVSENPSRFWWSGQIFGWTIGWSLFLGITGRRYHIPHVWVFMLVAQGVSVSFAANLFFAAIIVSSQPNEKDVSLVWHPQLLYELGPVALSILYTVAVPTFAYKQGFMPILLVPHLLVFIPCVLGPRGSSVPAKPDKAQFNYTTQRYVKFLQYVAAVSVALQGYLTILMLQHMGTDVPHNNVARYLLDTMYVHPACSSVSWDVIMCTLSAFVWMIVHKFDMSQMLGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUH4</accession>
    <name>A0A2I2FUH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_467966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699549.1">
        <property type="nucleotide sequence ID" value="XM_024852510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUH4"/>
    <dbReference type="GeneID" id="36560208"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467966"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="150" mass="16302" checksum="80A56BB33948A25F" modified="2018-02-28" version="1">MAQGDGRSGPGHAEVPFRDGESAISYAAISSMRSPPTSSSGITRSSSFSLHAMLYRAPSMNCIHPSAMPYSSTLCPSIFVRRCTDRPGKPSSSPLRWSLPAPWNSISPPWVTLSGSRRAEFPLRGVPPYSTSPDHPVRSMTEMYMTIQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUL0</accession>
    <name>A0A2I2FUL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_392516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699637.1">
        <property type="nucleotide sequence ID" value="XM_024845979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUL0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUL0"/>
    <dbReference type="GeneID" id="36553678"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392516"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB44335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="563" mass="58402" checksum="C909955911446688" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV11</accession>
    <name>A0A2I2FV11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_440763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699790.1">
        <property type="nucleotide sequence ID" value="XM_024850157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV11"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV11"/>
    <dbReference type="GeneID" id="36557856"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440763"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000630">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="227"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="359" mass="38785" checksum="5175974F6C59E36C" modified="2018-02-28" version="1">MSLTRAVALPLRRATVSKPYTAHPLRSASRAFSVSVRRDATWGFIGLGRMGYAMAKNLRAKIPATDTLIIRDVNEKATERFVQETREAARSSGAGDDTSKVLVAQNAREVAEQSTVMITSLPEPEHVKNVFYCVLRHGELPALEQERLFIDTSTIDPASSKELANAIHTTRQGRFVDAPMSGGVVGARAGALSFMFGASSQSGELVERVKSILLLMGKKAWHMGPPGTGVSAKLANNYILAINNIATAEAMNLGMRWGLEPKALAELVNTSTGRCWPMEVNNPVPGVVETAPASRDYEGGFGVSLMNKDLRLALAAAEESGSPLALGDQARSVYNAVEEQHRGKDFSVVYQWLKGQSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW79</accession>
    <name>A0A2I2FW79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromatin-remodeling complex subunit Ies6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_449969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700201.1">
        <property type="nucleotide sequence ID" value="XM_024851081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW79"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW79"/>
    <dbReference type="GeneID" id="36558780"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449969"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="188" mass="20651" checksum="7296D5C64DCD5FD5" modified="2018-02-28" version="1">MPPPTPAENEAHQRLLDSLDIAHVARPFRNPHWKPSQRRNKNVKQLISESTRKEASQMATQANSGATTPLPATSVSTDGTQTPADGTPRNPNIAQAAQNLSTLVLEKNARATFQPGPAVTYTNIESAPSLHPSQQTRYCDITGLPAPYTDPKTRLRYHDREVFGVVRTLTQGVPESYLELRAAHVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWM2</accession>
    <name>A0A2I2FWM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_429729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700317.1">
        <property type="nucleotide sequence ID" value="XM_024847910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWM2"/>
    <dbReference type="GeneID" id="36555609"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429729"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:linear primary-alkylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.30:FF:000001">
        <property type="entry name" value="Alkyl/aryl-sulfatase BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="entry name" value="Alkyl sulfatase, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.30">
        <property type="entry name" value="Metallo-beta-lactamase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052195">
        <property type="entry name" value="Bact_Alkyl/Aryl-Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223">
        <property type="entry name" value="ALKYL/ARYL-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223:SF1">
        <property type="entry name" value="ALKYL_ARYL-SULFATASE BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="89"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="607" mass="67157" checksum="93FB4D7B7AC5BBB5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWT4</accession>
    <name>A0A2I2FWT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_429806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700405.1">
        <property type="nucleotide sequence ID" value="XM_024847916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWT4"/>
    <dbReference type="GeneID" id="36555615"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429806"/>
    <dbReference type="OrthoDB" id="10335132at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="289" mass="33230" checksum="B879D47916B9BD00" modified="2018-02-28" version="1">MDSIGHIASCYLAVHIWIIFGLILAKAIDKYLPRPPPQQQQQQQPEDEIDPSELEPNNHLVSKALDFAMHTKVWPFWTELSGLELSPLLDAQNKILLEEGEKAISDEYGIPVEAVNEVRATRCLTDPDGPLVQDYLRRFDSFKWEVIARSLPAIAAMVSTPGQSQLKHMKPFPQERKRTEIWNKLCNRSTAPILRNIAKLQYTPTDNHHDYVRRCRGLVAELRKLKEVADWVEFKIFMAPLAKEAVLEPFIAHISRVYLKISLIEVYAKFVIYEDTRKGRVNYAIETNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWV3</accession>
    <name>A0A2I2FWV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">P170DRAFT_416050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWV3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416050"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="283"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="541"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="779"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1013"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1037"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="642"/>
            <end position="644"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="649"/>
            <end position="655"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB45108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1066" mass="118968" checksum="9E305474FED31970" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXE0</accession>
    <name>A0A2I2FXE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_416367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700584.1">
        <property type="nucleotide sequence ID" value="XM_024847115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXE0"/>
    <dbReference type="GeneID" id="36554814"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416367"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="10">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="440"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="515" mass="56444" checksum="6EBB31E3399AD50C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXL8</accession>
    <name>A0A2I2FXL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_241925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700669.1">
        <property type="nucleotide sequence ID" value="XM_024842961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXL8"/>
    <dbReference type="GeneID" id="36550660"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_241925"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="80" mass="9012" checksum="8C2DAC75E3021F5B" modified="2018-02-28" version="1">MLRNYLDQGYRVNKSSPGDLDHASLMNPPLPYQQMEVTGLTIPAGHDQNQVAGERAAPASKIMQRFEFADTEHSRETRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYN0</accession>
    <name>A0A2I2FYN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_439467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701043.1">
        <property type="nucleotide sequence ID" value="XM_024849839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYN0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYN0"/>
    <dbReference type="GeneID" id="36557538"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439467"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000023">
        <property type="entry name" value="Hsp70 chaperone (BiP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="564" mass="60551" checksum="4A9A9CC5C555D74C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYT7</accession>
    <name>A0A2I2FYT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_478720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701087.1">
        <property type="nucleotide sequence ID" value="XM_024853589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYT7"/>
    <dbReference type="GeneID" id="36561287"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478720"/>
    <dbReference type="OrthoDB" id="4468004at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="71" mass="7823" checksum="19A60F456C17773D" modified="2018-02-28" version="1">MPSSILTFLSKKDTSRNSSPSSDSGSEITLIERSKSHDGTRECTASQMRKSVNEREDFNAADLCFGSCCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ30</accession>
    <name>A0A2I2FZ30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_254420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701186.1">
        <property type="nucleotide sequence ID" value="XM_024843042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ30"/>
    <dbReference type="GeneID" id="36550741"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_254420"/>
    <dbReference type="OrthoDB" id="4177029at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16280" checksum="8A7C3EB3798AE698" modified="2018-02-28" version="1">MSSHWNCESCNFGPHSVELHKSCMRCGSPRTGNSSSEDMHSHHGLHMCNAMSPYPAPVHNHELSSSPLKGSSPVIKHGSSIPQPSLFGGDIHDRPTSNLASYSTEGARMHGSTFLYICCNCQDGPKTYNMQPRCVICNHVVCSNCQHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ48</accession>
    <name>A0A2I2FZ48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_429084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701213.1">
        <property type="nucleotide sequence ID" value="XM_024847875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ48"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ48"/>
    <dbReference type="GeneID" id="36555574"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429084"/>
    <dbReference type="OrthoDB" id="2129688at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46622" checksum="AE547B9FE879C836" modified="2018-02-28" version="1">MDDSNFPVFSDGDVRVWIGLKVYQLHSGVLEHHSRYFRYALREAPRFEGFAHFHVVPSQLTEVGALTLQESVSSPLAFESQFDDPAKVRAYWENILRALYKIKPNLHLPGRQLTAVASGLANLGDFIGSKAIVDEGIDLALQDLGQGLFLLIVSDPISWLYFGSRIRSKTIYREAVVHLVGRLPGLTPEDLERLVFLPQYTRDLLLDSYRTVCDAKKAAEALLWGYGSDLNDGPDSPMMKAVGLFRQWIAQHKALGNNIVSWDGGARLYRTIASGGQAYLPGDQFRYVYSPSVGELEAREILDRLAQVKDDVKQFVAPLLVNESRFDPQRFGQLPYLTCAKIDDDALPWNEWAIEDGNNSDTGLLGSEAGSDDSWISWADLESSDDAMADESSEKVERFHHLRQAKVVSNSVEPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ50</accession>
    <name>A0A2I2FZ50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_390183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701197.1">
        <property type="nucleotide sequence ID" value="XM_024845895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ50"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ50"/>
    <dbReference type="GeneID" id="36553594"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_390183"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="99"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="608" mass="66536" checksum="B16FA4AA7390F7D7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZC5</accession>
    <name>A0A2I2FZC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_467165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701291.1">
        <property type="nucleotide sequence ID" value="XM_024852458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZC5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZC5"/>
    <dbReference type="GeneID" id="36560156"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467165"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="545" mass="60895" checksum="39CB4DD935B0AFB2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0M5</accession>
    <name>A0A2I2G0M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_465953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701734.1">
        <property type="nucleotide sequence ID" value="XM_024852371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0M5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0M5"/>
    <dbReference type="GeneID" id="36560069"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465953"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="176"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="776" mass="87654" checksum="118AFC251B45EBA9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0N4</accession>
    <name>A0A2I2G0N4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GA4 desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_477303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701725.1">
        <property type="nucleotide sequence ID" value="XM_024853441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0N4"/>
    <dbReference type="GeneID" id="36561139"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477303"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="296" mass="33326" checksum="DAA323AC0F95D25B" modified="2018-02-28" version="1">MSLSQAVKTTLNYYPTCSVAGRQIVLGTIGTYRRPMDPRPATIQDVRGRESTFNLDVHGFQFLRHPSPHVSSFTESVVKKYMYPEAVDILKQATGATRAHVFSHITRNAPYEKVEELVASKESDTKPTSMMVPGRLIHVDQSESGALDILKDNMSAEEVARLSRSRWGIVNIWRPLKPVPRDPLAVADARSVRDEDLVEVYARLPGKGEKNYEATTQGAGFGMLYGMYGEGQKWYYLSGMRPDEVMLIKCFDSKDDGSVARRSPHTAFVDPRTQEVKEARESVELRCLVFFEDQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0T6</accession>
    <name>A0A2I2G0T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_387364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701796.1">
        <property type="nucleotide sequence ID" value="XM_024845800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0T6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0T6"/>
    <dbReference type="GeneID" id="36553499"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_387364"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000594">
        <property type="entry name" value="MFS alpha-glucoside transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF15">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="542" mass="59779" checksum="A57E60F0F8DFE9DA" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1C1</accession>
    <name>A0A2I2G1C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1 8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_438386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1 8"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701977.1">
        <property type="nucleotide sequence ID" value="XM_024849591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1C1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1C1"/>
    <dbReference type="GeneID" id="36557290"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438386"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000094">
        <property type="entry name" value="Lysine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="234"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="565" mass="63750" checksum="8A3556392C88C87B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1F3</accession>
    <name>A0A2I2G1F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIT finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_438414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702013.1">
        <property type="nucleotide sequence ID" value="XM_024849597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1F3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1F3"/>
    <dbReference type="GeneID" id="36557296"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438414"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="198" mass="22296" checksum="2EBB66A1747281AC" modified="2018-02-28" version="1">MSTSSQTGIKTADTCEVCSSERFKYRCPTCGLLSCSLSCTQSHKIYCTPREPSPKPPQEAVNDPSPQDEANGVIDGEGARETRNAFNPKSFASSPELKILFERYPSLRDELQDIYKATLEEEWVEVQTHGNRHRSFHRGKGGPRNRGPWTREKGFNRGLGKVRKFRERCDEGLETGRAAEGLMRFMNLVNGEHPEETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1I6</accession>
    <name>A0A2I2G1I6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_457242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702057.1">
        <property type="nucleotide sequence ID" value="XM_024851703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1I6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1I6"/>
    <dbReference type="GeneID" id="36559402"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457242"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000043">
        <property type="entry name" value="Acid phosphatase PHOa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014196353" description="Acid phosphatase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="447" mass="49683" checksum="FA19698851F1DF8D" modified="2018-02-28" version="1">MKSVVTALLAASVAYARTGTEKKPSQSEIEAAAASTEPHSPVSNVKGLAFDRFVQVWLENIDYEDAEEDENKQWLASQGITLTNFYATTHPSEPNYCAAAGGDTFGMDNDDYNQIPSNVSTIADLLDTKQIAWGEYQEHMPYPGFQGNDYKNQETKANDYVRKHNPLVLYDSVTENSTRLRQIKNFTHFDDDLENKKLPQWAFVTPNMTNDAHDTNITFAAKWERNWMTPLLKNSYFMDNTLVLLTFDEDNTYTKGNRIFSILLGGAIPDNLKGTKDDTFYTHYSVIATMSANWGLPSLGRWDCGANLLEIVANKTGYVNYNVDTTHLHLNETYPGPMSNGDYSEYSPEWPIPLTEGECSAGHGILDIVKETYKGTKPTFNYTSPFPYDTKSGYNEDVTATRKASLNGRSSAISASPESTANAGSSLTLPLIGSATGIFMEFVLGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1N0</accession>
    <name>A0A2I2G1N0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_477645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702078.1">
        <property type="nucleotide sequence ID" value="XM_024853492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1N0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1N0"/>
    <dbReference type="GeneID" id="36561190"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477645"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="152" mass="17404" checksum="1E3F05E933A763C3" modified="2018-02-28" version="1">MTLSRFSMERDVNWLNSPRVLESSIERLKTIKALDLDTALDFHDCLHKCMAKSLGELAKALEPHRPLFLEEPLFSEHPDNIKSLSGLVSCPIALSVRTARQPLRRETRRMSELRRIVVMVNTYDVALAPRFFLGMNLGIQYNQEAGEYDITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2C0</accession>
    <name>A0A2I2G2C0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_231633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702326.1">
        <property type="nucleotide sequence ID" value="XM_024842898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2C0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2C0"/>
    <dbReference type="GeneID" id="36550597"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_231633"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000020">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="10">
        <location>
            <begin position="303"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB47024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="410" mass="44543" checksum="CDF0B19D4020F6F4" modified="2018-02-28" version="1">MASPSRLTIVIKLGTSSIVDENTHEPILSILTLIVETVAKLHRDGHNVVLVSSGAVGVGLRRMDVDERPDNLPRIQALAAVGQCRLMSLWDGLFSHLRVPVAQILLTRNDIADRTQYMNAQNTFGQLFDMGVIPIVNENDTLAVSEIKFGDNDTLSAITAAMVKADYLFLMTDVDCLYTANPRHNPDAHPIEVVSDISSLEADVSSAGSSLGTGGMSTKIVAAKLGTSAGVTTVITRSSKPGNVHEIVKYLQRIQSDSHIHSAPGDKTGNEIPAPPLHTRFLPSEDPIQSRSFWLLHGLKPRGTIFIDQGAFTALQNKASLLPAGVLDVDGLFAQQEAVRIVVIQRISPDSLNGDFLHHGQEPKEVGRALVNYSSHEIARIKGHRSTQLQSLLGYADSEYVALRENISFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2M3</accession>
    <name>A0A2I2G2M3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear pore complex protein An-Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_412732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702423.1">
        <property type="nucleotide sequence ID" value="XM_024846941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2M3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2M3"/>
    <dbReference type="GeneID" id="36554640"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_412732"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="709"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="96728" checksum="F8576C659A885478" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3K2</accession>
    <name>A0A2I2G3K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_241075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702752.1">
        <property type="nucleotide sequence ID" value="XM_024842957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3K2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3K2"/>
    <dbReference type="GeneID" id="36550656"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_241075"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="262" mass="28633" checksum="01F8546002CFD566" modified="2018-02-28" version="1">MAHNPRHNPVLAVVGVGPGIGESVSRHFASKGFSVALIARTESKLRSIQESIRAQHGIHSAKFYVTDVRSESSVIATFSAIKSDLGAVKVLVYNAGSRRLRPRTLIETPTTEFEDFVKINMLGAYYASKAVLPDMLEGASGTIIFTGATASIRGSPGLGGFSPGKFGLRALAQIIAREFQAKGIHAVHVLVDGPVESDIIGSVVTKRWERDGEGEKVQEKDRYLMQPADLAALYWYLHEQPRSTWTQELDVRAQREGIFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4C7</accession>
    <name>A0A2I2G4C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_409963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703015.1">
        <property type="nucleotide sequence ID" value="XM_024846824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4C7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4C7"/>
    <dbReference type="GeneID" id="36554523"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409963"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="231" mass="26496" checksum="369557098B19BFC9" modified="2018-02-28" version="1">MAIITIDIISDIVCMWCFIGKRRLDKAIHLHKKTYPGGSADKVVITWHPYYLQHNPSPHSVEKRVLADKNLAHMTPEERTGLMNRMDQIGRAVGIRLNHHGKIGSTRDAHRLILLSQIEDKKRDQSHSGELQDAMAEKLFQAYHEQAKDISDREVLREIGRDVLGLQAAEVDAWLNDEDNGRRVDYEAQRNREQVSSGVPVFLIQGKEHRVDGAQDIEDFMELFVKIREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4K3</accession>
    <name>A0A2I2G4K3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_437523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703085.1">
        <property type="nucleotide sequence ID" value="XM_024849386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4K3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4K3"/>
    <dbReference type="GeneID" id="36557085"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437523"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB47783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="418" mass="44862" checksum="59AE5BDCE18C70A9" modified="2018-02-28" version="1">MAFIQDRAPYMVPTYVRPAPMMVKGQGCYLWDMENRRYLDLTAGIAVNSLGHCDPEISKIIAEQAETLVHASNLYHNAWTGALSKLLINTTRESGAMRDASQVFISNSGTEANEAAIKFARKVGRSLDPSGAKHEVVSFHNSFHGRTMGALSATPNPKYQTPFSPMLPGFKYGNYNDVEQLQSLITDKTCGVIVEPIQGEGGVNVATPEFLVALRKRCDEVGAVLVFDEIQCGLSRTGTFWAHAHPSLAPASGEAAHPDILTSAKALGNGIPIGATIVSGKTVAEHIKAGDHGTTFGGNPLVCRVAHHIVERLGSSELQNSVEVKSAQLVSGLEALQKKFPGVISQIRGRGLILGVQLSSDYTAKASELITAARERSMLIITAGDGCLRFVPPLTITEDQIKTSLKILEQAFDVVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4R7</accession>
    <name>A0A2I2G4R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM4</name>
        <name evidence="13" type="ORF">P170DRAFT_385857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4R7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4R7"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385857"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB47876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="119" mass="13219" checksum="294B43A9CEC4F5D5" modified="2018-02-28" version="1">MLPLGLLTAAQGHPMLVELKNGETLNGHLANCDNWMNLILKEVVQTSPEGDRFFRLPEVYIRGNNIKYLRIPEEIVEIVKEQQLNQPPNRGRGGHRGDRGDRGGRGGRGRGRGRGRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4U1</accession>
    <name>A0A2I2G4U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_199296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703189.1">
        <property type="nucleotide sequence ID" value="XM_024842752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4U1"/>
    <dbReference type="GeneID" id="36550450"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_199296"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="160" mass="18811" checksum="F347C737C62213F7" modified="2018-02-28" version="1">MLLKTYIQVCFWNATNMARVDSFGQSEKIDRRFQKRKKKKKKGKNKSRSNLEILIPIFTHNIISLEKRRAKVTFFLTWLPFCLVFYLPQSTPILFVEDRYFELFCFPYYLSFGLAIYSCSKSIICTVDYHYLRLRLGLHVGIAISLLSYGLKQPGPFTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5A8</accession>
    <name>A0A2I2G5A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_386271</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703369.1">
        <property type="nucleotide sequence ID" value="XM_024845759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5A8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5A8"/>
    <dbReference type="GeneID" id="36553458"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386271"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB48067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="312" mass="34456" checksum="9275F241DFC6CA7E" modified="2018-02-28" version="1">MAVSDTRFKLNTGAEIPALGLGTWQSGPGEVERAVSHAISVGYRHIDGAFCYQNEEEVGKGIKEALASGKVKREDLFVTTKIWSTYQTRVEEALDLSLKNLGLDYLDLYLVHWPLLMNPEGNHPLFPKHPDGSRDIIHSHSHIDTWKSMEKLLATGKVKAIGVSNYSKRYLEELLPHATVIPAVNQIENHPSLPQQEIVDLCKEKGIHITAYSPLGSTGSPLFSAEPIVEVAKKKGVTPATVLLSWHIARGSSVLAKSVTPSRIEDNRNLVKLDDSDMATIAKYTDELAAKKAFQRFVYPPFGVDFGFPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5I1</accession>
    <name>A0A2I2G5I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_410792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703438.1">
        <property type="nucleotide sequence ID" value="XM_024846858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5I1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5I1"/>
    <dbReference type="GeneID" id="36554557"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410792"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="371" mass="41232" checksum="4A9F3A36E99F8065" modified="2018-02-28" version="1">MTQPDYEVFQLGDWELQSGEKIVNAHLAYKTFGDPKSPAIVYPTWFSGLLSDNYWLVGEDKALNPQTYFIVIPALFGNGQSTSPSNYPGPRPFPTVSFYDNVRAQHALVTQHLRIGHLRAVIGWSMGAAQSYQWATQYPDMMDLVVPFCGSARTALHNQVFLEGEKSALLAAKHVQSAGSGKGGVLGSNQTLTAWSDNERQIGLKAFARGYAGWGFSQTFYRQKLYETVLGFQGLEDFLQNFWEDWALSKDPDNLLTMLQTWQNGDVSQQAPYDGDLEKALASIRAKCLVMPAKTDLYFPPEDSEYEVACMKPGIGTLRVIPSIWGHWAGGPGDSKADVKWIDEQLRDFLGANKQDASVEKIVQAGKDLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G601</accession>
    <name>A0A2I2G601_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_465710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703613.1">
        <property type="nucleotide sequence ID" value="XM_024852344.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G601"/>
    <dbReference type="GeneID" id="36560042"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465710"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="753"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1826"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2894"/>
            <end position="2970"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3968"/>
            <end position="4041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="4495" mass="497146" checksum="60C520A257738B9D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G625</accession>
    <name>A0A2I2G625_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_411092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703630.1">
        <property type="nucleotide sequence ID" value="XM_024846873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G625"/>
    <dbReference type="STRING" id="1392250.A0A2I2G625"/>
    <dbReference type="GeneID" id="36554572"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411092"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="42"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="437" mass="47922" checksum="F0FC5554671264EE" modified="2018-02-28" version="1">MGSQGQDVIDLFRGHPDPNLLPMGAMAKASAAVMAAPDVRAQAMLYGPDEGYRPLREHVAKWLTGFYQPRDPIPADRICITGGASQNLACILQVFTDPVYTRNVWMVAPTYFLACRMMDDAGFTGRMRGVPEDESGVDLAFLRRELEAAEEKAKAKGNTEPTHKPSRPWGKIYKHIIYGVPTFSNPSTLTMSLSDRVNLVRLAREFDALIITDDVYDFLQWSPDPSKSLANPDKAALPRIVDVDRYLDGGPKDEFGNAVSNGSFSKMIGPGTRTGWAEGTEKMAFGISQAGSSRSGGAPSHLAAAIIDQLFPTGIFPKFLEESLKPSYAKRYHRLMGAIRYHLLPLGVTLPSTPEIAGGYFIWVQLPAPLRASELAPVALQQQQVKVATGNLFQVQGDPSAGPDDFNRGVRLCFAWEHEDRLEEGVRRLACAVRNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6E9</accession>
    <name>A0A2I2G6E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_360079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703744.1">
        <property type="nucleotide sequence ID" value="XM_024844398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6E9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6E9"/>
    <dbReference type="GeneID" id="36552098"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360079"/>
    <dbReference type="OrthoDB" id="4478788at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="288" mass="32420" checksum="7558FE372818B9C1" modified="2018-02-28" version="1">MGSLTESYPLPLVSYADLLHDDKNTRDLAASDLIKSLNAYGACFFERPLQDKMAEYSNSNATSKSRFVPYASEKIRGMTHLDETLEFQHGVYDLPGTWDVPGSELVNASKDMHEECNRIHINLLDCLSSHLNLPQSLNTIHSKRNSFFAPYYYYFDDPNDTSTLRVPPHIDPTTMLFCFQDSHAGLNVADMSDFDGNISTGAVQDTARFVPANCKPGEFLLLAGHILRRLVDEVKHSVHFVERPLGSSGYHLNYWIIPDFDTACDFGGRQEDVAEYLARVFPAPLRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G736</accession>
    <name>A0A2I2G736_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_166824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703977.1">
        <property type="nucleotide sequence ID" value="XM_024842603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G736"/>
    <dbReference type="GeneID" id="36550301"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_166824"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="152" mass="16649" checksum="E74AFA3AC7EAC16C" modified="2018-02-28" version="1">MKQRGPLQIQGPAGLKPHPCQNPPGACSFTSLILMKNPPHSGLPIMITDQGVQGEKPKPSTSSFIQSHFPSHHLSLHVSSAWKAPTAACSHHAFRHSHCATQTVASPTDSSCWIQFCMAVEVRSRRLLRSGLLSFLFLFLLCFFCLSGMLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7P7</accession>
    <name>A0A2I2G7P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_407654</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704197.1">
        <property type="nucleotide sequence ID" value="XM_024846694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7P7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7P7"/>
    <dbReference type="GeneID" id="36554393"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407654"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB48895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="170" mass="18645" checksum="8B6A83DD1C214EB2" modified="2018-02-28" version="1">MASIARQSPLLRQTCLSAFRSPLATKNVSQAVAFHASAKKQILPPLPQVIHGSTNDPAPIPKPHPSEGSYHWSFERLVAAGLIPLTLAPFIGGTFNPVMDAVLCSFIVVHSHVGFQASIIDYFPARRVPKTFSFMNWLLRGFTLTTAVGLYEFETNDVGVTEAIKRVWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7W7</accession>
    <name>A0A2I2G7W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704245.1">
        <property type="nucleotide sequence ID" value="XM_024853243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7W7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7W7"/>
    <dbReference type="GeneID" id="36560941"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475277"/>
    <dbReference type="OrthoDB" id="3903267at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37647" checksum="E070451B9CD3498D" modified="2018-02-28" version="1">MGPSKRSLNRPKKRTLVRWDENLNELLLLTVQSVCNIQSVKIPWAEVAKTMGHNVTEGAIVQHLAKLRARRAAIGKDVPPPLRRGGIGAAIKPSPSKTSTAPKRKSRNSRSMDSDDESPFPIEYDDSSDEDYTESRRTKRNPKKAKRASSPIKQEFDSEKDNREEGSASSDELLVPGAAFLDYPNDVSEDSSAESNSSPARKSKIVILKYRRHNTFDQELAAQGEVVPAPVLTEADVPDPESIDNVKSEQALGYDFNANMLLANFEPNHSDPLVYQNFETMPEASYITHDSVMYGNPLENHSELPIGMMGHPEFIQSEDFQFLNYQDLLGAEANLDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G859</accession>
    <name>A0A2I2G859_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_357144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704371.1">
        <property type="nucleotide sequence ID" value="XM_024844199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G859"/>
    <dbReference type="STRING" id="1392250.A0A2I2G859"/>
    <dbReference type="GeneID" id="36551899"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357144"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="470" mass="51150" checksum="751D64E8A97984D2" modified="2018-02-28" version="1">MAHGIEAAVEQLRAAFAHQFVTPDLEAKFQQAVAVPWSQTCWTPAAGYVYLKDSLELTRAVDIIKSTGSKFAVRTTGHNPNAGFSSADRDAIVLDIRQFQSKELTSDGVARVGSGSTWGEVYAWLEGHKLSAIGGRDRQVGLGGFLLGGGMGALPNLYGLGADGVKNFEILLADGSLVNANANENADLHRALKGGGSNFAGIVTRFDLETHPLINVQYTINAYNLDDYVAINKATVAVQKAMEEDSKIGLFTNYNNGLVAVGMLYGGTPNEPPAAFQQFHELNSLLMTVLPVTNGTLLSLAEAMGHVQDSKKRAICTSTTQVSQELYDEVYKYWVDIRNTFPADHVLHYTIQPMGTAGVQEGKNRGGNIMGHQIIPQTWWVFTCEWPEDGDDVAAQGAVDKMLAKVQSLAEERQLLLDYRCMSFAQASQRVLGSYGAENIQRLQDVAAKYDPEGVFQKLQHGGFLLRNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8L7</accession>
    <name>A0A2I2G8L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Single-stranded DNA endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_408300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704527.1">
        <property type="nucleotide sequence ID" value="XM_024846723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8L7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8L7"/>
    <dbReference type="GeneID" id="36554422"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408300"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000063">
        <property type="entry name" value="DNA repair protein RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0255">Endonuclease</keyword>
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    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="707"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB49225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="975" mass="108955" checksum="B3358CAE5FEE1013" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8M0</accession>
    <name>A0A2I2G8M0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704528.1">
        <property type="nucleotide sequence ID" value="XM_024853269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8M0"/>
    <dbReference type="GeneID" id="36560967"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475534"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="64" mass="7069" checksum="C7CC24030E8B79E5" modified="2018-02-28" version="1">MPTIPSDPTNFPSLESQKEGQKGAEDKPKATAQDFQSKGPQIPDSMPPKASREEIEARMKELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9N8</accession>
    <name>A0A2I2G9N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_447237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024850861.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G9N8"/>
    <dbReference type="GeneID" id="36558560"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447237"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="186"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="7">
        <location>
            <begin position="464"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="969"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1172"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1297"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1343"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="738"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="934"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1358"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1369"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1429" mass="156634" checksum="0DED1CFE06EB0E19" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA54</accession>
    <name>A0A2I2GA54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_437264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705050.1">
        <property type="nucleotide sequence ID" value="XM_024849324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA54"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA54"/>
    <dbReference type="GeneID" id="36557023"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437264"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="288" mass="31441" checksum="4679730BA6AF5430" modified="2018-02-28" version="1">MSAQITHPPSANLAFPDPATSAFALPNVPLTPGFFSLPSLANTVDWPLSDTLPTPPPIPSWAIKPDPDGLNPPSQQQKSLCIDPSLQPSSKPSPSTTASTKPPRSASSSTPTSSSASSQTPPSQSKSQISKDRLKRENFLARNRMAASKCRQKKKKHNKALENEYERVAREKKLLQTEADYLRAQVLQLKDELLRHSQCEDASIKGHLNKMVTQVAMTRKSDTFIDINSLLTTSEEEGSVDADSPLLQEVMEPERRDLYRMGEGEVDAAGPGVGVRTGDNFDDFVDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAG5</accession>
    <name>A0A2I2GAG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_132919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705173.1">
        <property type="nucleotide sequence ID" value="XM_024842423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAG5"/>
    <dbReference type="GeneID" id="36550119"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_132919"/>
    <dbReference type="OrthoDB" id="10495151at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014176833" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20177" checksum="A5B7352656C85AE8" modified="2018-02-28" version="1">MLTKSLLAALPLSLWAVAHAETMMEPFDIFMSSDSTVQYARGDKVDNNAICQTMGDGEYTFSLLLEQQLDDDRDMCANSTVAIMDNDCVIQDILKYPDEVTNSQLVPQDYPYTIFEDFLQGAIVIDVGQFCELADDSDPHVQFGYMGSQYKASNSDYCNSIVDSDHELWACGKAFNVEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAI5</accession>
    <name>A0A2I2GAI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_424331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705186.1">
        <property type="nucleotide sequence ID" value="XM_024847559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAI5"/>
    <dbReference type="GeneID" id="36555258"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424331"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="271" mass="29201" checksum="0890CA142A713B9B" modified="2018-02-28" version="1">MPSYLVTGAGRGLGYGFLKQLVLNPENTVFGLTRDADAARDRLAADGLASRVHIVQAEITSHSSLQRTAKEVEVILGDKGLDVLINNAAYVSEVTAWKSLVDFEENQDLLINDLQKSVEVNIFGAMRVNYAFLPLIKKGSVKKVLSISSGMSDIDFINATKIPVATPYAISKAGLSTVTAKFNASYHDQGILFVALCPGNVDTAEGKQFSKEERHGMQAMGALVAPYAPDWKGPFTPEESAAVCLSRLGQLSLEKGHGGVFLSHNGTKKWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAK9</accession>
    <name>A0A2I2GAK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_355986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705221.1">
        <property type="nucleotide sequence ID" value="XM_024844118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAK9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAK9"/>
    <dbReference type="GeneID" id="36551818"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355986"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="511" mass="57982" checksum="799B89A729B2A22E" modified="2018-02-28" version="1">MDYSHDEAVATVASQVQSFHSRQQPFRIYHGSTNSTRDSPYGRDNIVNTAPLTHVLQVDPTAQTVLAEPNVPMDQLVQATLAHNLVPLVVMEFPGITAGGGFSGTSGESSSFRHGFFDATVNWIEIVLPNGEVRRASQKDDPELFWGAASAFGTLGIVTLVEIQCRPAKPLVELTYHSAASMDQAMQVFRTATADQTIEYLDGIVFAKNHVVVCAGRLVDSPPEGGPVQRFTRAQDPWFYIHAQRRSPAPSAGSNTPPSVTHYIPLEDYLFRYDRGAFWTGRFAYQYFLTPFNRITRYILDFFMHARVMYHALHQSGLSSYFIIQDVAVPCGGTTEFIDWLDHKDSFGSYPIWLCPLRHSEGVMSRSRDLSDANTETNSETDDGYIMNFGLWAPSPFHNDRQAFIAQNRRLEGKVRQLGGKKWLYAHAYYTEDEFWSIYNKKEYDSLRAKYHASYLPDLYQKVRVNLVPGNGSQSWESWMRGLFWSVWPVSGLYGVYKAWRGGEYLIRKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAN2</accession>
    <name>A0A2I2GAN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_473518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705243.1">
        <property type="nucleotide sequence ID" value="XM_024853052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAN2"/>
    <dbReference type="GeneID" id="36560750"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473518"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="391" mass="44710" checksum="395C1D6C0F3BD63A" modified="2018-02-28" version="1">MPVVDFGELELGIDSAMIEYMNTREEDTLDSLTTMLQQQFANNHYTPAYSFLHTDIYGRTEPISMVDYLALIWSCIVGPNWDIVTKSLVKLGSVSSNTMQFGALYQVLVRETFGEAGFLLISDLVQKGGPIELFCSSGTFKKNIRYIIAEMLKVLVLFPEIVNIILREFENELQHALKSKEFSIQSTFFGERSLLDVAFGWPRGVQVLPDWGLSPDCTLNIHTLSNLKDTSDGSSDLDGYYESARIMINAGWKWHLAGRRDLLNCKSTKKLRSLFINDLVDQRTDLWKQAQQLLPPDELPHLKKGPVLDFNASRVYEALVAQGYLEARERNGVQEILEEEKPLREVLERLIAQFEAKHAELGLPILEFLEKHWYTRMVHFLLSPDPYDEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBG7</accession>
    <name>A0A2I2GBG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_139511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705534.1">
        <property type="nucleotide sequence ID" value="XM_024842456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBG7"/>
    <dbReference type="GeneID" id="36550153"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_139511"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="153" mass="17744" checksum="813B1CFFAB807FAE" modified="2018-02-28" version="1">MDSSPLDFFTEYGVQSICIHRLKKEKKKREREKKRRVRLSAGFVHALSTHVEPTLNKYILPPLESQNAAKRCLWIRSILDSSVDRTTVQVDLQSWLPINLCPLSQLACGRFSQASRGQSEDTQAKTKPTVTLERWEWRRQTRQISVYVVSCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBM0</accession>
    <name>A0A2I2GBM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_424678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705580.1">
        <property type="nucleotide sequence ID" value="XM_024847585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBM0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBM0"/>
    <dbReference type="GeneID" id="36555284"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424678"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB50278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="538" mass="59933" checksum="4197CC6520489DC9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBQ5</accession>
    <name>A0A2I2GBQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="7">SDH assembly factor 2</shortName>
            <shortName evidence="7">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_454871</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705613.1">
        <property type="nucleotide sequence ID" value="XM_024851482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBQ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBQ5"/>
    <dbReference type="GeneID" id="36559181"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454871"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014131031" description="Succinate dehydrogenase assembly factor 2, mitochondrial" evidence="11">
        <location>
            <begin position="25"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="37"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="514"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="647"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="691"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="791"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB50311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="819" mass="91205" checksum="3B4243F42520F4CA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCB4</accession>
    <name>A0A2I2GCB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase MEC1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">DNA-damage checkpoint kinase MEC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Mitosis entry checkpoint protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">P170DRAFT_381301</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705822.1">
        <property type="nucleotide sequence ID" value="XM_024845562.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GCB4"/>
    <dbReference type="GeneID" id="36553261"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381301"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000017">
        <property type="entry name" value="Inositol kinase kinase (UvsB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000031">
        <property type="entry name" value="Phosphatidyl inositol 3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="24">
        <location>
            <begin position="1443"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="23">
        <location>
            <begin position="2131"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="25">
        <location>
            <begin position="2434"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PLB50520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2466" mass="277564" checksum="33E3D8DAC7F3542C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCI9</accession>
    <name>A0A2I2GCI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_148918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705877.1">
        <property type="nucleotide sequence ID" value="XM_024842510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCI9"/>
    <dbReference type="GeneID" id="36550207"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_148918"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15761" checksum="E0F4876B665DF8FD" modified="2018-02-28" version="1">MVGRWLEGQAGVKSILCNRHRAVLMLTFCTCDLVGCLNTPRFCFILFYFLLFLGGIIWFIIYFSDWLRLIDLLGFFLECWMLTRAPSTVTCSTTNEDREKNRLEKEKEKKKRPKKKRGQKHRRRQWFLVMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCL9</accession>
    <name>A0A2I2GCL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_381566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705938.1">
        <property type="nucleotide sequence ID" value="XM_024845577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCL9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCL9"/>
    <dbReference type="GeneID" id="36553276"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381566"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="13">
        <location>
            <begin position="97"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB50636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="522" mass="56830" checksum="A9B4AC74CDC7041D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCP1</accession>
    <name>A0A2I2GCP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_353748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705943.1">
        <property type="nucleotide sequence ID" value="XM_024843993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCP1"/>
    <dbReference type="GeneID" id="36551693"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_353748"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="495" mass="54672" checksum="2E81FDE42CEC7B80" modified="2018-02-28" version="1">MKGDVETIEHVKPGPLQQLPLPIELASLDPEQIKALEKDLVKRLDCCLLPAVIILFLMNILDRRNNIANAKIAGLPTTLGISNTQYNTCLMIFYVGYIITQLPSNVIITKVKPSLYIGLVTAAWGLVSLCQAFTRNFAGLFICRIVLGLVEGPFLPGVFFLMSCWYKRSELPPRIAFLYGANMLASAFGGLIAAGIVARMEGKLGRPAWEWLFIIEGSMTIAIALLVIPFIPDYPGSTNRWWLTPNHQVLADWRLRNENAGIVDDDPESLLWGVKQAFLDPKLYMFIVLQMSLLTAQSFNNFFPSIVGTLGYNETITLLLTAPPYFFAFLCSLCISFHGARVNERGLHIAVPLAFALLGNLLAMFIRSLGARYFSMFLMTAGSYSPYNLVVSWLSSTLPRPKTKRAAAFAVVNLMGAGVAHFYTSYMFPDSQKPRYYAGGGVMSGACLVCACTAMAIKWHLKRENRRIERVEVEEGVVGGGAIQGGAVVAFRFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD13</accession>
    <name>A0A2I2GD13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_474338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706086.1">
        <property type="nucleotide sequence ID" value="XM_024853125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD13"/>
    <dbReference type="GeneID" id="36560823"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474338"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="362" mass="39052" checksum="83287F9FB942313C" modified="2018-02-28" version="1">MAQPTPEQIEYYMKHADDDKRPNEIASLVCGLLAAILAVGARFAARRISRISLGPEDWTIMLAMVGELTYAIVFAVAIDNGQGRHIIFVKDAVSFSKGYVAAIVSYSFTVMVTKISVLLFYCRLFGSKWIYTSSWILGAIVFLYNLAVIMIAGLQCIPLSDLWTGGPSCIDTESSFTGLAVVNIVTDVLILALPVKPVMNLNMKSARKVQVLGIFLLGGVVCVFGIIRAVAMTELSLLDPTWTAVGAAMWSFVEISVGIVAACLPMLGPLIRNRSGASTNQFASNGYVRSGKFSATVSSKSGYIQQDDIPLTDDWRQGGRTVAPDDRSYQAQGGPPVSPSLSKQNPKRVSAQQDAQSTTTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDN7</accession>
    <name>A0A2I2GDN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,6-mannosyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_455295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706285.1">
        <property type="nucleotide sequence ID" value="XM_024851515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDN7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDN7"/>
    <dbReference type="GeneID" id="36559214"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455295"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB50983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="468" mass="54411" checksum="74ECBBB4A1B9CFB8" modified="2018-02-28" version="1">MSLSRSPSPHPGAGWSSPGLTPGSGNSTPRNGLLSPTSLGPGGISWAAAKAKSEEVRGYPSFSTRNNGFFSRSKRQLTATLPRFRGTSGSPDGYFEKKDAYYDRGRGLSSGAYWRSCGFGRTMMRRRRLRFLLALVLAALGYLCFWTYFLERYRRSPLGRGHKFVVILESNVEGGVMEWKGASEWAVERSSIENKKRYANHWGYELEIVNMLAKKRYSHEWRESWEKVDLIRETMRKYPDAEWFWWLDLNTWIMEYSYSLPNHIFKRLDEIAYRDINVYNPLNISHPPTGAYLDDVSRSPDGDQDPSSIHFLLSQDCGGFNLGSFFVKRSQWSDRLLDAWWDPVMYEQRHMEWEHKEQDALEYLYTTQPWIRSKFAFLPQRFMNSFPPGACGDGDDPDVHYLEGGRDFVVNMAGCDFGRDCWGEMSQYRDYSNWLNRSWRERTEDSMHGLYDWVTGWFQGPESQQQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE50</accession>
    <name>A0A2I2GE50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_464160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706481.1">
        <property type="nucleotide sequence ID" value="XM_024852223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE50"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE50"/>
    <dbReference type="GeneID" id="36559921"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464160"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000093">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcF), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="425" mass="45417" checksum="84ADDCFEEDE353A3" modified="2018-02-28" version="1">MPPSHKRLLKEASELSASPSPHFHAAPALDNLYDWHFTLAGPPSPSPYAGGIYHGRIVLPPTYPLRPPSFRFLTPTGRFEVNREICLSISGHHEESWQPAWGIRTALIAIRSFMDGDAKGQVGGLDVPEEVRREYARRSGGWCCEVCGRSNEVILEEWRGECREKGVVVDGDGDGEVEVVQRQDGEETETKVDKMEDGQDSKTEDSKANGSRENGLSEQVSERVPEDANVDSLPDAGSSAKSEPLQEQQSSSSLASASASASASTTTSAPTPASAQPATSSTTTTPPTPTRTTQPAVAPVSQSTHPDASQDGPWLDRAIVGVLIALVIFEALLNKASCSCGSATRPPRAYCTSKTPSTPTSPYLYVPCPDASLVGAETSARQLALVATFSLANMAIFFCQKLIHVAIRYLAGIPLLSIATPEFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE54</accession>
    <name>A0A2I2GE54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="13">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_446312</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706480.1">
        <property type="nucleotide sequence ID" value="XM_024850784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE54"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE54"/>
    <dbReference type="GeneID" id="36558483"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446312"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="16">
        <location>
            <begin position="246"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="630"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="810"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="933"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB51178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114337" checksum="19B962CE172D3D56" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF72</accession>
    <name>A0A2I2GF72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1392250.A0A2I2GF72"/>
    <dbReference type="GeneID" id="36560537"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471444"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
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    </dbReference>
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        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="96446" checksum="04C64D8CF37CD279" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF83</accession>
    <name>A0A2I2GF83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_443720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706823.1">
        <property type="nucleotide sequence ID" value="XM_024850577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF83"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF83"/>
    <dbReference type="GeneID" id="36558276"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443720"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="346" mass="39162" checksum="A3C42FAB03F72F69" modified="2018-02-28" version="1">MFKPRTTGEWLFCGVLIIQAVIVLSLETFTLVQWSSWVHPNIIQVTISYITPLNLGILMFACVYLTALGLDAIYHKNDVLLLAICASNTCGLVYSAMQYRNIRQTIHRLPLSFDGLNQPFVDLDRDIWPAVKPAQLAAPIIIGLCTLLLWPLAYQLHCQFAWELYRSIHGNTNMKQRFRAYEIYIVLLKVDFYFIVGFILQYNLIDVHFDEPEYSLTMALIPVTLIVMVSGIYFARSERMIPMLCVTACYLGMIAYLLSRIIILCGNGLRARTAGKDMMILFASVALALTTLTIVSVIRCMLNFDRGLKHVLKPKALSPRGSYVSQHLSEHPPSPVHSAHSRMSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFG3</accession>
    <name>A0A2I2GFG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_376568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706924.1">
        <property type="nucleotide sequence ID" value="XM_024845375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFG3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFG3"/>
    <dbReference type="GeneID" id="36553075"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376568"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="489" mass="54244" checksum="E1EF550119009C52" modified="2018-02-28" version="1">MVADTTYYDALGVPPTASELEIKKAYRKLAIVTHPDKNPGDETAHARFQAIGEAYQVLSNEDLRKRYDKFGKEDAVPASGFEDPSEFFGMIFGGNAFVDLIGEISLMKDLTATMDITMQEMEEEELAASAEEKLNIHDQETKAAGETEGTQPAAAADTPTADTTAAPAPAAAPAPTAAPEESTPAEKPAAASSSGRSAPRRPLGQQAIMDKSEEEARMEAAGLSAEEKELRKKEKKKGLSREQQERLAAYELERKKAREERVDTLATKLVDKISVWTETDKGTDVTRAFEEKIRLEVENLKMESFGLEILHAIGQTYVQKASSFLKSQKFLGISGFFSRLKDKGTLAKETWTTISTAIDAQMTMEEMAKLEERGGEDWTDEKKAEYEKKVTGKILAAAWRGSKFEIQSVLRDVCDQVLGDKRIKLDKRVERAHALIIAGNIYQKAERDPEEEGDYMAFEQLMAEAMTKKGKDEKKKKKKHEHEEEATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFY0</accession>
    <name>A0A2I2GFY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_433610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707039.1">
        <property type="nucleotide sequence ID" value="XM_024848535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFY0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFY0"/>
    <dbReference type="GeneID" id="36556234"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433610"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="9">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="149" mass="16802" checksum="B1B41D046DBE3BAF" modified="2018-02-28" version="1">MPTRFSKTRKARGHVSAGYGRIGKHRKHPGGRGMAGGQHHHRTNLDKYHPGYFGKVGMRYFHKTNQQFWKPTINLDKLWTLVPAEKREAYLSGQKTDTAPVIDLLPLGYSKVLGKGRIPEVPVVVRARYFSRDAEKKIKEAGGIVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG06</accession>
    <name>A0A2I2GG06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA processing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707117.1">
        <property type="nucleotide sequence ID" value="XM_024848552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG06"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG06"/>
    <dbReference type="GeneID" id="36556251"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433688"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="201"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="430" mass="48966" checksum="74528F8224761E71" modified="2018-02-28" version="1">MVSKKSLARPPPGAVSDEKPANKIRRQLLHVKRKRAKDSARRAERYAFKKEEAKNPKLKDERLKRNIPLTLERKRVWDEADSDAEDGLGLSVDVERIKRQKQEEEDELNRPLDPSEQQSEGSQDDSDDVDSMLASSDDEKDDGDDDEDDDDHPRGRSKSSIPSATARATSPTQSSKSTNLNLAPEALAAKFPSLFSTETPKTPKILITTSINSILHDEAEILTSLFPNSVYIRRTAHRYSHKFSIREIASFATNRQYTALVILQEDQKRPAGLDIIHLPKGPMFHFTISNWITGKKLPGHGNPTEHWPELILNNFRTPLGLLTAHLFRSLFPPQPDIEGRQVVTLHNQRDYIFVRRHRYVFRQKRETEKSVVGADGKEMKGAEGLRTGLQSLGPNFTLKLRRVDKGIQRASGQEWEWKGGMEKQRTKFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGK9</accession>
    <name>A0A2I2GGK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_471927</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 18">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707316.1">
        <property type="nucleotide sequence ID" value="XM_024852886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGK9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGK9"/>
    <dbReference type="GeneID" id="36560584"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471927"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24301">
        <property type="entry name" value="THROMBOXANE-A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24301:SF2">
        <property type="entry name" value="THROMBOXANE-A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 18 19" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 19" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB52014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="465" mass="52142" checksum="997ECCA8FC024215" modified="2018-02-28" version="1">MPTPIPRPKGLPIIGNLFDLDSNNPWGSFNKLATNYRPIFKITILGKDIVFVTGAALLEEICDERRFRKCVTGPIVEIRDAVHDSLFTAYHDEESWGIAHRIMAPLVSPEAVAGVFAGMQETSKDLVRKWTAGPRQRVSVTSDLDRVNHAANMLCFFDQRVHCMDGPEPAVIRAMDSSTKESMKRAARPSFLTWLFHQSKWDKDIKTMRDYCASIVATRQENPTDRKDMLYAMLHGKDPQTGKSLTESQVLDEIINIFIGSATAPNLVAFAMYYLMKNPDEISKAREEIDNVVGGPSDEIEHEHLARLPYCEAILRETFRMSGVAPGFNIEPIPDDSDSPVFLAGGEYEIPRKQPLIAILSSVNRDPAVFENPEAFKPERMFGEKYERLPTGVKKGFGNGKRRCFGAQYAWEWSFMALVTILKDVEFEAADASYTMANAGVNYNGAFSVRPQEFFAVTGPRPRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGT3</accession>
    <name>A0A2I2GGT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_350521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707384.1">
        <property type="nucleotide sequence ID" value="XM_024843808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGT3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGT3"/>
    <dbReference type="GeneID" id="36551508"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350521"/>
    <dbReference type="OrthoDB" id="4436899at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="170" mass="19450" checksum="06D65DA9E07F5066" modified="2018-02-28" version="1" fragment="single">SFPNPFLRARGLSGTTTPAGVGWNDDLILEVLGDDGQPKYPHVTMTMLHNYNGHENSMLYGELAPLISAMRSRANQPLVTDEEEMEKLYDEKRDVFPEKQRVFPMEKRFPVLMLSFLGPQHARIFYACLDGKNLIIRQSKLYSFESKADAPVELFARFLLSTPRDERVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGU9</accession>
    <name>A0A2I2GGU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative adam</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_350384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707408.1">
        <property type="nucleotide sequence ID" value="XM_024843798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGU9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGU9"/>
    <dbReference type="GeneID" id="36551498"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350384"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF31">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="308" mass="33304" checksum="535F6200168CCA00" modified="2018-02-28" version="1">MQGYTHNGPIDCDVDVDPRGLKGKTAIVTGGANGIGEAYTRALVAAGATVCIGDLDTDKGKKLESELPRTKFLPCNIANWADQLALFQAAVSLSPTGKISYVIANAGIHRPDEVFAVAVDDQAPPQKPDLSVIDVNITGTLYTTKLATHYFVKQNGQTPSQDQDDTCLVLIGSGAAFLDCPRTPQYCASKWAMRGIMHALRRTAFYYGSRANVISPWYVKTNILPEEAIARVEEVGVQFAEPEDAGQCLLRVLSDSSINGRSIFLSGRKWASRGYIDLDLEDYAGNALVQEIQEDQMKAAPPSMGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHP9</accession>
    <name>A0A2I2GHP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_103339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707713.1">
        <property type="nucleotide sequence ID" value="XM_024842280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHP9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHP9"/>
    <dbReference type="GeneID" id="36549975"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_103339"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB52411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="197" mass="21874" checksum="89D6C0BE91430340" modified="2018-02-28" version="1">MDLCGRQKVVRRKMVLLGDGACGKTSALNVFTRGYFPTVYEPTVFENYVHDIFVDNVHMELSLWDTAGQEEFDRLRALSYEDTHVIMLCFSVDSPDSFENVASKWVDEISENCPGVKLVLTALKCDLRKDEFENNNANAIAYEHGLAKAKEIGAVKYLECSAVQNRGIMETFYEAAKVALEVKAPGSTASKGGCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIB6</accession>
    <name>A0A2I2GIB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_351016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707916.1">
        <property type="nucleotide sequence ID" value="XM_024843832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIB6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIB6"/>
    <dbReference type="GeneID" id="36551532"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351016"/>
    <dbReference type="OrthoDB" id="4828554at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="138" mass="15540" checksum="FCFD2D51EB55B847" modified="2018-02-28" version="1">MAERRISYAPDVENGDHSRSTADVNEGAGLDEYGALNRYISTARDGRRGSTSSAGGFSNKKNKKPWYKFWGGKGDTVEEGFVCPDDWLETDIRSGLRSGDIEPRRKRTGWNELTTEKTNFFIQFIGYFRGPILYGESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ39</accession>
    <name>A0A2I2GJ39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_115880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708194.1">
        <property type="nucleotide sequence ID" value="XM_024842334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ39"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ39"/>
    <dbReference type="GeneID" id="36550029"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_115880"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001649">
        <property type="entry name" value="C2H2 transcription factor Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="529"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="607"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="780" mass="86596" checksum="3B2C75EB26E1B73D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJE9</accession>
    <name>A0A2I2GJE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_434719</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708300.1">
        <property type="nucleotide sequence ID" value="XM_024848778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJE9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJE9"/>
    <dbReference type="GeneID" id="36556477"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434719"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="147"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="204"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB52998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="252" mass="27830" checksum="AE226EA5C649DB39" modified="2018-02-28" version="1">MAFRSTAEEMESFQLSDSESDDLWNSPSQRTRREIFPKPANEASTTTPPPRPSHDEETLFGQEEAREAALRNELQSVRNINQIIEGLLGSLDSAKGNMDTVSRTVDSASTLLNTWTRILAQTEHNQRLILNPNWQGAVQDVADMENEEALRQQAAERRERELQQQREAATRRAEEERRRAQTTTTTRGTRGTTRGRVRTGGLGRTPSVSYSGTSSGTRTTSSTAKGSSSTSTRRPVSGIARGPGVARGRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJJ2</accession>
    <name>A0A2I2GJJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_462842</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708348.1">
        <property type="nucleotide sequence ID" value="XM_024852121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJJ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJJ2"/>
    <dbReference type="GeneID" id="36559819"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462842"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF24">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB53046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="205" mass="22678" checksum="CBCE3DFF698A5D96" modified="2018-02-28" version="1">MHISKLYLLAYNTLGAILWLRILLTLCFLALSHPSASTLPLPTTIYTTLEPQTRWAQTLAVADVLHAAAGITRAPVFTTFTQVFARSVQVWAINYGFPGVTGPSGAYACMLLAWSVADAVRYVYFVALLSGSGFETGVVRWLRYSLFIVLYPVGIASEWWLMYGAATTTQRGAVSGVFYFCLGLYVPGSVMMYSYMIKQRRKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJS7</accession>
    <name>A0A2I2GJS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_379605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708440.1">
        <property type="nucleotide sequence ID" value="XM_024845492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJS7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJS7"/>
    <dbReference type="GeneID" id="36553191"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379605"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="511" mass="55052" checksum="8C580FED9E384106" modified="2018-02-28" version="1" fragment="single">MLLTLKPSSQNGVKGPPHDYAIVRQSIPAAPRASSPPPATSEPQTQSMESSRRGLPPPSALTLPPPDVAFAAGNPMSQQPLPPRPPPQRPDSDASYYSWLEAKAEEDRRKQEEEKTRQETLRLEQRRIEQSMLRDSLHAGVPPHMIPLIFAGISQGGVPQSVLEVSQQYMAQSAVPPPPRGPPAPSSMPGLSHSSSQRRPPHARRDSRSIPSSSSHPYVTSTQQPVPGPGVLLSQPLHAPAPSSTPQSMGRSSDPRAAPTMSRLNTGESQGSQQQPAINLSNVHYAPGSSVPLSQPAGGKSDSQPRQSPPSLYFHHWVPPAQSQPNTPRNRQESPGASQAPRRPDYQNSPGRKRKAQGPHQQAPLPSSRPSDHRPGSSQNSRSGSPMISARPAEQSSHTRQRSDTSNPYDPRIPDHHGPEPSSRRASVTRPTIRTMTSAEETGSERGYSRTEDQDRSGYPSRSESHANYSHPASQGPYASSVGTAPPDSDADSSPGHSPRTGSPRRLRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJY9</accession>
    <name>A0A2I2GJY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_125238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708495.1">
        <property type="nucleotide sequence ID" value="XM_024842382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJY9"/>
    <dbReference type="GeneID" id="36550077"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_125238"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="205" mass="23518" checksum="B0857EC60C40635F" modified="2018-02-28" version="1">MEYRGRSEFLVRYLPILGPDSAVRKTEVQDMRVGSVHDWFPPLMTAARQRGRRITKDDEARRTPGRRRAASNMQGEQRRAVIGIGLRIRIIRSSSLSEGAVSSPEGFRMTVLLGGFDRWIARRGDETNAPLDFLLKTFAVASDGDQGYRVGWCFCWRSYIPGCTPEEAVRGWRMSYQLEDLTCEQRQRVSRDHGYGSFKSFRLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK88</accession>
    <name>A0A2I2GK88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_404258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708571.1">
        <property type="nucleotide sequence ID" value="XM_024846514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK88"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK88"/>
    <dbReference type="GeneID" id="36554213"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404258"/>
    <dbReference type="OrthoDB" id="4505602at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014175384" description="LysM domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="358"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="583"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="664"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="712" mass="75552" checksum="8A1A50187D7B552F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKJ7</accession>
    <name>A0A2I2GKJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_129596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708708.1">
        <property type="nucleotide sequence ID" value="XM_024842405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKJ7"/>
    <dbReference type="GeneID" id="36550100"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_129596"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="172" mass="18887" checksum="D048013A942A3D7C" modified="2018-02-28" version="1">MCLRVIHPLAATSGPADGYPLGFIGRETQTTPPPVAPPSPPCLAGSNHRARRQSRLQQNARPAHAWTLLGRPGPPRLISRRPLRKTLKGRPFPSGSRPSRSLQLISPSQSETEPILRHQDTQICLHPASISFHHPSTLPPSTPLVARFVTVKSAAPLDHYPVCYYLPSSTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKU8</accession>
    <name>A0A2I2GKU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_463176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708815.1">
        <property type="nucleotide sequence ID" value="XM_024852148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKU8"/>
    <dbReference type="GeneID" id="36559846"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463176"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="126"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="334" mass="36836" checksum="C1DF810E488823EE" modified="2018-02-28" version="1">MSRSLSPVFKLASLSRQQISSPSSLAALRRAPTSLRMSSTAATAAAPQAQSNYKIVEKVENFEKTQASRPDFNHSAPIEVTKSPDPKWQYGDGVNDQNASLNKTHRQIDPYAPDRATVHNYRLLISGVAPRPVGFLSTVSGDGKTKNLSPFSYFQVIDHDPPMFIVGFSSRPGRVKDTYRNLKETGECVINTVSEKMIEAVNASSIDAPYGVSEWDVSGLHEAPSSTVKASRVQESVFSVEGKVVDIKEFEDHVQPGMSIASLVLIKATRFWVQEDAVNEEGSHIDLEKLRPLGQLGGMSYGRVSSTFELPRKRWQDDQPNSELLTRLEASKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLT6</accession>
    <name>A0A2I2GLT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_420640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709137.1">
        <property type="nucleotide sequence ID" value="XM_024847306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLT6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLT6"/>
    <dbReference type="GeneID" id="36555005"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420640"/>
    <dbReference type="OrthoDB" id="4332097at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="116" mass="12988" checksum="63960AF10309B899" modified="2018-02-28" version="1">MLIYVGKLSYPPYASNELVTVIFRDNIQSGDLVSVIHQWSKDASGKEKANSHAHGTVNKVASGSEGKKEVEILYENRDKTYYWYKGTVSGDTLTLSMWNKGGEKVADSIRLHLAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMD4</accession>
    <name>A0A2I2GMD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_397036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709338.1">
        <property type="nucleotide sequence ID" value="XM_024846152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMD4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMD4"/>
    <dbReference type="GeneID" id="36553851"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397036"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF1">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="902" mass="103809" checksum="ED0899997CD1C8FA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GML8</accession>
    <name>A0A2I2GML8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_482554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709443.1">
        <property type="nucleotide sequence ID" value="XM_024853887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GML8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GML8"/>
    <dbReference type="GeneID" id="36561585"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_482554"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37384" checksum="22BBE5CFA36DBADC" modified="2018-02-28" version="1">MTSHIIDPTGEVTIILQDADAPFAVWDEETPATNESPSSGTIEPIEEIHNDKTDETKCEDKEVRYQVSAKHLTLASPVFKAALSDAWKEGSTLPQGSAEIEVHGWDSQALLVMLSILHWQIDALPGKVGIEFLTKIVILADYYGCLSVIKVFGWGWFKLMQSSIPNEYSRDLMMWLCASGLLGEREVYERLAVIAIKGSKDIIMTLGLPFPSSMIEHLNTNRERVIQGIVDSLHSAVDSLARFNSNNAAPSTPSDSCTACNAIKLGTLMMAMRSLSLWPKPQPPFCGLSFGGIRASIKSTREKEFKLQNHGRCRSLATMLTYLDTSSWSRMNQSIKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPF1</accession>
    <name>A0A2I2GPF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_505447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710051.1">
        <property type="nucleotide sequence ID" value="XM_024854289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPF1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPF1"/>
    <dbReference type="GeneID" id="36561995"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505447"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="264" mass="29500" checksum="99A85663EFBDBCEA" modified="2018-02-28" version="1">MNHVADSIPSDLLAIPPLSSQTPLPQPLYKPIKILVIHGHGSSSSRAFYKYRGLQPLIRHHIMHTLHRDVEFYFPNAPLLPAGFEPGMWTWGLGDYRVDRVPGLQESVSFLVRYMEEHGPFDGVMGSSAGATVAIVVASLLEGDLLRGGCEEVKMKTNHPPLKFMISYSGFKMGHARYRSIYRPKIQTPIMHFIGELDTYIPGTLTLKLAERCVNNQVVYFPGGHYIPRLKRTTVAAAGFICDCLDIGGCDDESEWEEVDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPI7</accession>
    <name>A0A2I2GPI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_24667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710075.1">
        <property type="nucleotide sequence ID" value="XM_024842993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPI7"/>
    <dbReference type="GeneID" id="36550692"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_24667"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="133" mass="14173" checksum="036178A26DC22AB4" modified="2018-02-28" version="1">MGKLTVPPAQKFQNRPASRLTPKVSGAKHEVLYDGHLPRGPGGTNSVRFHGHWTSRGDSPWLVAPKVLLPSLGGEEVLALRCISGMFGLVTMVSASWIGDDRDIALTSHGLPMHVVGDIPCMGDVTSLVGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPI8</accession>
    <name>A0A2I2GPI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_432376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710097.1">
        <property type="nucleotide sequence ID" value="XM_024848249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPI8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPI8"/>
    <dbReference type="GeneID" id="36555948"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432376"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="325" mass="35354" checksum="797A1B02A77EAB54" modified="2018-02-28" version="1">MSQSLPPPFTPDSEFAALETPRAPAGSLSITALARFEFEAGKANDGTKILMIEWEDDDLARCGSSPVIHTPSSSETEIETETVEETPASETEPEQPTTTSPSQDLIKKRAAGSWHVSWENKTAVLPASEQTNDHTRRVYFLLPPNVTIPPVVTLAYEPAPANHPTEYPAASETLQLNPLPAIFPPELGADGRSAGKKGVLHTIWAKKRLQVLEREIREECRSNVEGVALQMALQEKEWIEMNFGVGGAQAATEAVRNRVNAHDASYPMGPTTPVSPTTGGRLGEKLKGLKLQTGGRGKEFTSSPLTTEGMYFVHADESPKLMTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPJ4</accession>
    <name>A0A2I2GPJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_24986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710099.1">
        <property type="nucleotide sequence ID" value="XM_024843016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPJ4"/>
    <dbReference type="GeneID" id="36550715"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_24986"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="103" mass="11437" checksum="3C4E4A3D0DE50ED6" modified="2018-02-28" version="1">MQGISKANPPDPKEPSGRLGRYLGKCRRARTIGAEGARGRFQVWLKNAGRVDCRDDRECLDRAVGWYWGWAATARLLLLSRLFLASYGGLVSVVGRREGGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ69</accession>
    <name>A0A2I2GQ69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_452557</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710329.1">
        <property type="nucleotide sequence ID" value="XM_024851284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ69"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ69"/>
    <dbReference type="GeneID" id="36558983"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452557"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="261"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="481"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="675"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1136"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB55027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1242" mass="139604" checksum="EAFE8885F991206B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRN6</accession>
    <name>A0A2I2GRN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710825.1">
        <property type="nucleotide sequence ID" value="XM_024848396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRN6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRN6"/>
    <dbReference type="GeneID" id="36556095"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433051"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06197">
        <property type="entry name" value="FNR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="155"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="391" mass="43067" checksum="27C1707693E9A702" modified="2018-02-28" version="1" fragment="single">MPEAIRFLDRADTFFMSSRNGTVDMDTNIRGGPPGFVRVVSNEPSGVVFVYPEYSGNRLYQSLGNLQVTPLGGFVFPDFETGNALFATGKVEILVGKNAAAVLPRSNLAVRVTVTAARYVEKSLAFRGIAGSLSPYNPSVRYLATEKATPAMMDGPAITATLVRKEIITPRIGRFRFRISDPKQIGSWTPGQYATFSFQEELDMGYRHMQDDDPSSLNDDYVRTFTISSHPDKDLPPDEFEITARKNGNVTSHLFRTNERAGLEVPLKGFGGDFVINSHGGQDLIPFIAGGIGITPVLAQLPGLDISRLHLSWSMHVDDIGLVVDTFHRFPELPQSTRLFLTGPDPQDDKVVQHLKAIMATAARVERRRIDAADLDLSLADVWYFCGSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRR3</accession>
    <name>A0A2I2GRR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_461394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710856.1">
        <property type="nucleotide sequence ID" value="XM_024852033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRR3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRR3"/>
    <dbReference type="GeneID" id="36559731"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461394"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="548" mass="59692" checksum="4F074E31008D5E1F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRZ5</accession>
    <name>A0A2I2GRZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_461461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710942.1">
        <property type="nucleotide sequence ID" value="XM_024852037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRZ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRZ5"/>
    <dbReference type="GeneID" id="36559735"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461461"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25469" checksum="CE0B2103E886F147" modified="2018-02-28" version="1">MVHPVTELIYFQLKSTVKPEDLANEEGQALLDLFNNTKQQSGYQSSAWGRTKEDENIVVWVIDWADAHDGIQQTLLTPYIEPSTQATIIFTTLTPPPPSSTTPKTHRLTTNPVTELCALAFPNTMAPEEHEALSSDLINFRRALTESLPEGSRPTAWAMGYVERPGTMAHEKSGDGQAFVHLLAVGWESKEKHMEIKGTEEFTGSIQPIREKMLSPVPGLGMKHVSFVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS84</accession>
    <name>A0A2I2GS84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_443458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711035.1">
        <property type="nucleotide sequence ID" value="XM_024850547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS84"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS84"/>
    <dbReference type="GeneID" id="36558246"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443458"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF6">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33791" checksum="ED55BF0CBA133F6D" modified="2018-02-28" version="1">MALPIHVAILDLDVPVPAIYNTRGLYSSIFRRLLESAASRLNATRTRPIAIHTSAWDLIGGNYPPLSSFLTSPPTHSSSEDTQSTNPLALPISAILLTGSAPAAYETATYPWIAPLADFLSLVYNDYPHVKIFGSCFGHQILAQTLLSPPLRNELCPDGREMGLVPISLTGEFRDSFPALRDRLPGDGEKMRLQMIHGDWVVPASGARDAVVLPAPWMNVGSSEACPIQGLYCPKRVLSYQGHFEFDAVVNAETCREFGRRAAWKPELMVEWLRLIELGKGKSEGEDEDDAKVAAEVVVLFFAGEDSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSM0</accession>
    <name>A0A2I2GSM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_506385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711181.1">
        <property type="nucleotide sequence ID" value="XM_024854389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSM0"/>
    <dbReference type="GeneID" id="36562095"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506385"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="81" mass="9098" checksum="176D12A19A9831E2" modified="2018-02-28" version="1">MSSSLRITRWSSTEEVVDAVRGFKDALNDPNVSDETKQKARQTLDRLERGTQCDPDDKGKETDQETGGPRSWRANDSLDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRD7</accession>
    <name>A0A2I2FRD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_441664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698506.1">
        <property type="nucleotide sequence ID" value="XM_024850370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRD7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRD7"/>
    <dbReference type="GeneID" id="36558069"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441664"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="623" mass="68870" checksum="87E1110B1881CD93" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSE1</accession>
    <name>A0A2I2FSE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_55757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698844.1">
        <property type="nucleotide sequence ID" value="XM_024855271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSE1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSE1"/>
    <dbReference type="GeneID" id="36562977"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_55757"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="466" mass="53835" checksum="BBFA8725F9913898" modified="2018-02-28" version="1">MDSLMNLNSAMDSLRFSDDQLRAFRLVLHFLSSAARLRESRWEVGTCIPEALFNSVLSNQKRIQRIALITDGECGATNSSQNYVDLVQVRELRSLDWRGLCRYTDFESVRQCVRAHGHQIQSLTLDLLTWDRAEDIWAYGYRQQSPQRTPIPDNFFSQRVLNIQLRDKTVIFSSLESLHLSGVSFYHTGMEMAYAFNVGQLKSLKLRNCPGSFEWVGMILEKPMKLKSFELALDLDSIRRAAYLHITETICNFLQYVSDLESLYLALPVPIDWTTLTDRLSSHCHLRRFVIHNLMDRGGQNLIDGDIPWSLPLKHMLQKKQLTCFGSSMAPRKLTRYLQMMQPKPSCKMIHIRTSGVVLDRLFGSRQPNWFSQSFYAYKYGEDFPYKTEDIYNFAQWAFGADGLSNLQVLAWGDFSYRGRYSKFNLLLCRSDGGYRTLTPSDTIPWSLVQDNLDMLAACAFEDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSH8</accession>
    <name>A0A2I2FSH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">3-ketoacyl-CoA ketothiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_480558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698897.1">
        <property type="nucleotide sequence ID" value="XM_024853791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSH8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSH8"/>
    <dbReference type="GeneID" id="36561489"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480558"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="295"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB43595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="418" mass="44170" checksum="B42CAB9D5C1C49BE" modified="2018-02-28" version="1">MATDRLSSILSHLKPSGGNGLSTITQKNPDDVVITLALRTPLAKAVKGGFKDTELDFLVYSLLKEVLSKSKVDPALIEDVCLGNVNDGKAAYLVRAASLAAGIPHTAGGSSVNRFCSSGLKAVQDIANQISLGAIDVGVAVGAELMSAPGERITKPFNEEVLRNQEAADCMQPMGQTSENVGADFNIPRAVQDKYAAESYRRAEEAQKAGWFDDEIVPITTKVKDPKTGEVKEIVVSKDEGIRYGTTAESLGKIRPAFPQFGDKSTGGNSSQVTDGAAAVLLMRRSKAIELNQPILAKFCGATVAGVPPRIMGIGPTAAIPKLLTKFNLTKEDIDIFEINEAFASMAVYCLDNLGLEHAKVNPRGGAIALGHPLGATGARQICTVLSEARRTKKKILVTSMCIGTGQGMAGLFVNEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSR3</accession>
    <name>A0A2I2FSR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_368643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698956.1">
        <property type="nucleotide sequence ID" value="XM_024844872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSR3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSR3"/>
    <dbReference type="GeneID" id="36552572"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368643"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="572"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="679"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113809" checksum="D15D7F79199A9D72" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSU9</accession>
    <name>A0A2I2FSU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_369629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699015.1">
        <property type="nucleotide sequence ID" value="XM_024844916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSU9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSU9"/>
    <dbReference type="GeneID" id="36552616"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369629"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="267"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="588" mass="65877" checksum="CA495677894487AF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSX9</accession>
    <name>A0A2I2FSX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_514074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699050.1">
        <property type="nucleotide sequence ID" value="XM_024855168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSX9"/>
    <dbReference type="GeneID" id="36562874"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514074"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="100" mass="11232" checksum="465AC853C35BFD7C" modified="2018-02-28" version="1">MPSLQEITTLINKASPFMFISFLLFSNAFHYYVGTTDSEFILSQNLSVLVALAGVYIRDSFPGNAKLKLLSSVTTTVAFIFMPKPYLVLIPGFKEWWGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT50</accession>
    <name>A0A2I2FT50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_393821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699130.1">
        <property type="nucleotide sequence ID" value="XM_024846034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT50"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT50"/>
    <dbReference type="GeneID" id="36553733"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393821"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052926">
        <property type="entry name" value="Metallo-beta-lactamase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754:SF13">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="339" mass="36628" checksum="66056448C55E8A91" modified="2018-02-28" version="1">MLAEIDTLEIHVLVNDELDPISPSPNPAVQVASRFMGIPLSPLDPASERGGAQMEMRMDNICCAAHGISLLLIATKGDKKHVLLFDAGPEGDVWERNSARLRAEVGRIEHVALSHYHRDHSGGLTRAIELINASKLATGGTGTAVVVDVHPDRPAYRGVQADRPISLEADPSFEELEAAGATLVKSDRAHTVLDDFFLVSGEIPRDTTYEDGIYGGIRFNEGTGQWEEDTLIMEERYVMCNIKGKGLVVFTGCGHAGVVNTCRDAVKLGNGSSLYCVVGGYHLADADDAKLNATMGDLKKLDPKVLLTGHCTGWRFKCVIARDIPNCLVPCFSGSKYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUW4</accession>
    <name>A0A2I2FUW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_286362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699732.1">
        <property type="nucleotide sequence ID" value="XM_024843206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUW4"/>
    <dbReference type="GeneID" id="36550905"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_286362"/>
    <dbReference type="OrthoDB" id="10666919at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="325" mass="34186" checksum="B39D9D056C938E84" modified="2018-02-28" version="1">MSAQFFPYSPVENGGNKGGRPLSYQPPAPRFYAPPAPPKISTPPQSDSLQPTPPTSYRHSHSFSTTYAGGPGYGHPPVNMRERSSSHSLAPTPYYPGRTSAPSSPRLSPSSGAHLGAPNGQTPQTRSRSGSFSPLPMALQPGSGPSSRPHSPPFSSAYPGAPNGQAPQTRERSSSYSPHPMQLQPGSRPSSRPHSPSLSFTGGDELHFGDISHSSSRQPSPPSSSQGSLPPALQATQQLSLHPQGVDHGPPASRERSPSSSFRGYAPYVAPQPQPQQFPPQPQQTPPQTAAPALMYPQDAPAPLFNGGYPTGPLPSINQPPAIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUZ8</accession>
    <name>A0A2I2FUZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_468143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699771.1">
        <property type="nucleotide sequence ID" value="XM_024852535.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FUZ8"/>
    <dbReference type="GeneID" id="36560233"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468143"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014125578" description="chitinase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="291"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="355"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="498"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1105"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1184"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1032"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1111"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1201"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1402" mass="149633" checksum="CA95241B51E68BC2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV75</accession>
    <name>A0A2I2FV75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_417244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699845.1">
        <property type="nucleotide sequence ID" value="XM_024847167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV75"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV75"/>
    <dbReference type="GeneID" id="36554866"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_417244"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60792" checksum="D3A3FF68F86F8CC0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVH0</accession>
    <name>A0A2I2FVH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_368381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699945.1">
        <property type="nucleotide sequence ID" value="XM_024844857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVH0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVH0"/>
    <dbReference type="GeneID" id="36552557"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368381"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000558">
        <property type="entry name" value="MFS quinate transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF43">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="538" mass="59662" checksum="361F94DCA1323BEA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW05</accession>
    <name>A0A2I2FW05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_440047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700122.1">
        <property type="nucleotide sequence ID" value="XM_024849978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW05"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW05"/>
    <dbReference type="GeneID" id="36557677"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440047"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="608" mass="67320" checksum="28741AEB4AA13B55" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWC4</accession>
    <name>A0A2I2FWC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_512994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700168.1">
        <property type="nucleotide sequence ID" value="XM_024855050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWC4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWC4"/>
    <dbReference type="GeneID" id="36562756"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512994"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF37">
        <property type="entry name" value="AMIDASE C869.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014112849" evidence="1">
        <location>
            <begin position="18"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="586" mass="63292" checksum="141C8F59DAF13C5B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWK6</accession>
    <name>A0A2I2FWK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_458611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700323.1">
        <property type="nucleotide sequence ID" value="XM_024851808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWK6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWK6"/>
    <dbReference type="GeneID" id="36559506"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458611"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="407" mass="44211" checksum="F7560EFF8F37339C" modified="2018-02-28" version="1">MTSPHTEKSTTTQEEHHLLHRSLTEKLYMVERAHGVNLHLSNDQTVLDACAGAAVAIIGHGNEEVSYVHMQSYTTAAAEQLANSILEGSPYGLEKAFFFGSGSEAVESALKLARQYLLKRASRKECILLPDGQSYHGNTLAAMSLSGNMARKVPYEGFAYPHVSHVSPAYAYRYKKGTESEDDPEKVIAFVAEPVVGATSGCVTAPRGYFARVRELCDKYGILLIFDEIMCGVGRTGSYFAFEQEDAVPDIVTLAKGLGGGYAAISGVMVHEKVIDVLRQGSNAYNHGHTYQAHPISCAAALAVQKIVRREGLVSRCAAMGRVLEELLHIRGLGLFWAVEFVRDKASKETFDPAVRFGLRVQQAAFEKGVAVYPGAGSADGIRGDHVLLAPPFTITEDELETVCRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXQ2</accession>
    <name>A0A2I2FXQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_389205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700713.1">
        <property type="nucleotide sequence ID" value="XM_024845859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXQ2"/>
    <dbReference type="GeneID" id="36553558"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_389205"/>
    <dbReference type="OrthoDB" id="2408539at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014179601" evidence="1">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="154" mass="16889" checksum="6D5342BE17F932B4" modified="2018-02-28" version="1">MKLSVAVASFLAASVSASFDKYQPWGKRDYSCVNIYQGIPDNSTVAPGAEIDLRFNRAPTTHCADPLSKYEAGTYSVWLYNNPVRNLDTISFDQSLKLKTGIRESDGAVTVTIPNNVTAVKDSSVWYLRVDTYLPNAPQMPTLFDAAGPFTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY09</accession>
    <name>A0A2I2FY09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700819.1">
        <property type="nucleotide sequence ID" value="XM_024849803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY09"/>
    <dbReference type="GeneID" id="36557502"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439267"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="58" mass="6880" checksum="A22A712F1C87F69A" modified="2018-02-28" version="1">MSSWRSELVNIHRGTETPAPDWPEEKEKGTGPRNSWTPDKRRLHPSYQWILCWIYGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYH1</accession>
    <name>A0A2I2FYH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_449316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700970.1">
        <property type="nucleotide sequence ID" value="XM_024851037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYH1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYH1"/>
    <dbReference type="GeneID" id="36558736"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449316"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="525" mass="57352" checksum="6BF7DB6C2BE1536E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYH6</accession>
    <name>A0A2I2FYH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_365281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700987.1">
        <property type="nucleotide sequence ID" value="XM_024844695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYH6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYH6"/>
    <dbReference type="GeneID" id="36552395"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365281"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="110" mass="12756" checksum="760B8FC37D61EC1D" modified="2018-02-28" version="1">MGLAYNVYLTSNKIFGCKQCKTHLADYDDIISRNFRGQHGKAYLFNNVVNITQSEAVERSMTTGRHIVRDIACRQCRETVGWKYDKAYETSEKYKEGKFILEEELLCVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYM2</accession>
    <name>A0A2I2FYM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_466966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701035.1">
        <property type="nucleotide sequence ID" value="XM_024852449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYM2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYM2"/>
    <dbReference type="GeneID" id="36560147"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466966"/>
    <dbReference type="OrthoDB" id="5416589at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="237" mass="26450" checksum="D260E41C6A3C53CE" modified="2018-02-28" version="1">MTPTEPPKKNPQSRTTDSLTFEKKNQDMIKLPKYARVQKRPIPHAPIASPYAGPTVPKTVYVSTKSPFMSAVKRVQKLLRQAEKRATASVDLSDRKARDRQRLGDIARSGEQLCREEVFVKATGRAMEKALSVGRWFEERADEYSVRVKTGSVLVVDDVVEDEEARKEVEEGAVVKEQEQGEEKGAGDEEGTAKSRSKTAAKKRKRAANAAAKLGEEELPETRTRWVNMVEVAVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYY9</accession>
    <name>A0A2I2FYY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_364977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701140.1">
        <property type="nucleotide sequence ID" value="XM_024844678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYY9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYY9"/>
    <dbReference type="GeneID" id="36552378"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364977"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPAF-like PDZ" evidence="2">
        <location>
            <begin position="92"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="1">
        <location>
            <begin position="272"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="616" mass="67186" checksum="FD067D2EBE5B5F31" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ78</accession>
    <name>A0A2I2FZ78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bax inhibitor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_439644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701246.1">
        <property type="nucleotide sequence ID" value="XM_024849885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ78"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ78"/>
    <dbReference type="GeneID" id="36557584"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439644"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="269" mass="30642" checksum="88B7F0102C6D81CF" modified="2018-02-28" version="1">MAANTRYEPAPQRDSFEERAYPQPPPSYQATADYAQPRSEDDNVPDDFKFGGMVAEGTLPIRMQFIRKVYAILTAQLLLTTIMSSISFFSDGYRTWIQSHPWLMFVSVFGAIGFMLATFWKRKSYPANLLFLTGFTVLEAYSVSVVTSFYDARIVVQALILTLGIFVALTLFACQTKYDFTSWIPYLFGGLLFLFMFGLMAMLMHSKTTELIYSGLAALLFSAYILVDTQMVMRHYHVEEEIAASISLYLDILNLFLAILRILNNQQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZI0</accession>
    <name>A0A2I2FZI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_467155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701278.1">
        <property type="nucleotide sequence ID" value="XM_024852457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZI0"/>
    <dbReference type="GeneID" id="36560155"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467155"/>
    <dbReference type="OrthoDB" id="4506787at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="420" mass="45176" checksum="62A971D0D9B084DC" modified="2018-02-28" version="1">MTRPKLQLKLKHEMGALSTLLFPCLQRKQRQRQTPSTEKPDENDNEHDRPPVPAKDAAVTLNEKSDSTSSSSNGASGATAPTYTYTYTYRQSEKQHHHPSSPSPPEPNNANASKLTKRSSIRIVNSTESDSESTLVSSSAASTTTAGETLSGSGSGSRSVSRSGSEEKDLELGGDRSASSIIEAGLEDLERQIRSDAERTGLTRSRSLPEIKSRVIEDIPEEEELGLGTGSARILPLGEKQLPCLPREADPVDAEKGTGEEEKEKEEEEELTSKTKSLRDSFRRSGRKSLIEMVNFLQPPTNRFSTLKLPIPPKSPLRKCASASSMPSSPSSSDMAPTATPSEQSPSPSSEGDPKAEEEESKSPTPRTKKHRRMGAVGMGIGMGMGMGLPLRVRRSIDGLSISNTDGSKSQLGKVSAGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZJ3</accession>
    <name>A0A2I2FZJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P170DRAFT_478973</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701351.1">
        <property type="nucleotide sequence ID" value="XM_024853609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZJ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZJ3"/>
    <dbReference type="GeneID" id="36561307"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478973"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2900:FF:000002">
        <property type="entry name" value="Mitochondrial intermembrane space import and assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="21">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="208"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PLB46049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="291" mass="31077" checksum="4B5C568590E455ED" modified="2018-02-28" version="1">MFRPASRVLLRAPATARGPASRRLISTAPAEASKSRSWKNTAVRLGLAAGAVYYYNTASVFAEPPSFSLREQITTSEPATSLTLDSVKPKIRAQKESESQSKPAPSPSADAPQQQQPSGSDAAVNPQELEEEASQEAAFNPETGEINWDCPCLGGMAHGPCGEDFKAAFSCFVFSTEEPKGIDCIEKFKAMQDCFRQHPDVYGAEIDDDEEAPAAPPVSAEDAPAAVAPQSTASAAEIEASSHPDEKRARAKETVAETKTVAAGQPELAESDELLPKAWHDTEAKNEQSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZN7</accession>
    <name>A0A2I2FZN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_500969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701404.1">
        <property type="nucleotide sequence ID" value="XM_024854157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZN7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZN7"/>
    <dbReference type="GeneID" id="36561863"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_500969"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="499" mass="56478" checksum="CF2EF4F4963B14D2" modified="2018-02-28" version="1">MTIYSQPPTTAIIIGAGFSGLTMACQLKRVFNLEDFYIYDRAEGIGGTWWSNTYPGCAVDIPAICYSLSFAPNPNFTKLFPSQPEILDYVHDVASQYGVHSHFVGATEWRGARWQESTKTWTVTFENLRTGHIFTQRCKILISGVGGLVNPNRFDVPGAQNFKGDIVHTARWNPNLDLTGKHVLVVGNGCSAAQLVPAIADQTKTVTQFMRTPHHIMPSQNYEISPTWRIIFRCVPGLLFLIRLLMFLYMETGFLQFGKGKAESASRRSSAQLSAGHVRNTAPEKYWGLLTPDFEFGCKRRVFDHGYLNCLNRDNIRLTDDRIIHVKEHSVLTKSGDEIFAHAIILANGFALTQWDVDIRGRNGITRKQHWEKYGSKSAFQSIAMSDFPNFFTLIGPNSGRAHTSTLLSIESYTNLILSAIEPVLNGSARSVEVKASSERRFNSDVHLALEQMVQNASCASYFIDKDTGKNWFVYPWNSLQLWWSTWRRCDDDWVYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G037</accession>
    <name>A0A2I2G037_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_458340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701549.1">
        <property type="nucleotide sequence ID" value="XM_024851788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G037"/>
    <dbReference type="STRING" id="1392250.A0A2I2G037"/>
    <dbReference type="GeneID" id="36559487"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458340"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="632" mass="71480" checksum="12561D3F38293C49" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0E1</accession>
    <name>A0A2I2G0E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CoA-dependent acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_438160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701642.1">
        <property type="nucleotide sequence ID" value="XM_024849525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0E1"/>
    <dbReference type="GeneID" id="36557224"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438160"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="51092" checksum="A7E3543B579E942B" modified="2018-02-28" version="1">MPWTAAEPSPNTVSRPLGPNEVFIKLVSDPGHPLGREHWAVNYTATVHPRGAFAALTGPRDLLPRLIRHSWLHLRFQHPSLAAHPDASNSQLVYTVPGSAEALSEWASETFLVVAEAKCADEVIPTIAPAPDARLYYIPRSGELLLHSAHWRMDGVGGLLLLGQLVDLMVSHADSLLSRNLPDPFDSFPWGSEVARLSPPVEEAGNMPLAASDEQKAVAHGAVGTFARAAGALGVPYTGDASTVPAGTLAVELTFSPATTSAAVSAAKARGVGITAALHASLAAANFRRAITEHRGRHYTSTIKQSLRPYLPEPYSTPAAAAGLFTSGWLARVDPSGTWQENARMYHAEYQKGISPEYLQAHREYASTLVDVIRKLPTPAEPPSDVDISSMGVLEKYLQREYGTPERGFGIAHAGVGVEMLSRQGVVFVWTFRDQLTLRLVYNEAFHTPQQMREFLLDVQADLLKELEVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Q9</accession>
    <name>A0A2I2G0Q9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701769.1">
        <property type="nucleotide sequence ID" value="XM_024849552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Q9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0Q9"/>
    <dbReference type="GeneID" id="36557251"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438250"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="1">
        <location>
            <begin position="330"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="627" mass="69194" checksum="2131C31E8F9A9868" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0S9</accession>
    <name>A0A2I2G0S9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_438263</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701789.1">
        <property type="nucleotide sequence ID" value="XM_024849556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0S9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0S9"/>
    <dbReference type="GeneID" id="36557255"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438263"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="574"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1115"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1247" mass="137858" checksum="FD07B65F72905849" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0X2</accession>
    <name>A0A2I2G0X2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_511278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701832.1">
        <property type="nucleotide sequence ID" value="XM_024854870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0X2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0X2"/>
    <dbReference type="GeneID" id="36562576"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511278"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38808" checksum="8A3D7BF4CF6E2A3A" modified="2018-02-28" version="1">MQEQPQTKVLITPELLEIILLHLDTRTLLVSAQRVCRTWTALIQTSPAIQQALFFQQTARNPNLERDKWNTESIWHSLLPSRLQENGKIDQGSINGYESPHPPRIYNPLLVQAFPPFFPPIHDNEEKATETETQTEHEGREKENEISFSFKPLDMLSSPQKKTAYMRKEASWRKMLLCQPPVDGGVAVFKVIHSRIGDSYSCYKVPQKTPRPHQEERVDHGDILKMDHFFTTLTQNPDVYFRRLSETHVYWSAYVPPCDPDISHWHGGIYPPRGGSFNPRVKKAFAEAIEKFEVVIYSMAMLECDSGEERVLTDEECLREEIVEAETEESKEREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G182</accession>
    <name>A0A2I2G182_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_427931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701931.1">
        <property type="nucleotide sequence ID" value="XM_024847812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G182"/>
    <dbReference type="STRING" id="1392250.A0A2I2G182"/>
    <dbReference type="GeneID" id="36555511"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427931"/>
    <dbReference type="OrthoDB" id="4444247at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="813"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1256" mass="136309" checksum="9ECBE8CD8B75136B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1L7</accession>
    <name>A0A2I2G1L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Peroxin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_387650</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702058.1">
        <property type="nucleotide sequence ID" value="XM_024845816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1L7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1L7"/>
    <dbReference type="GeneID" id="36553515"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_387650"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="84"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="407"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB46756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="484" mass="54202" checksum="3DAEF116DCA9EE71" modified="2018-02-28" version="1">MSTTNFAAAQERVLERRRLREAEARARLAEQQRASPVNHPALQRLPYPLSRLPQSGLSLWNAIKGREGMRPAFRVGQVDAELLDEELLGLLKGQVGEALKYFGPQMREDWSHEIQFALRAILFKLSIWDHDASYGAALQNLKYVDSRSKGPVHSTPTRWQKTLYGLLTVGGRYAWDKWESWLINQEGGYDEPSQEVRVLSRMTDLVSTTHSIAAFTSFCVFLVNGRYRTLVDRILRIRLTPPSAQASREVSFEYLNRQLVWHAFTEFLLFLLPLVGISRWRRWLSRAWRKTVSTLKSSGDDDDEQVRKQGELAFLPERTCAICYKDNNPTSTTENEVMAASTSAGIIGSAQTDITNPYETIPCGCVYCFVCLVQKLEGEEGQGWVCLRCGEIVKKCKPWNGDVLEEARPQSSSGKVVGFAVNDGDDGVGANAGEPEKGGEHPMGRSSPLQDLSSDEALGESNHWSTIDKDLAEDGPEGQTDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1R2</accession>
    <name>A0A2I2G1R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_438512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702108.1">
        <property type="nucleotide sequence ID" value="XM_024849614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1R2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1R2"/>
    <dbReference type="GeneID" id="36557313"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438512"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="911"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1021" mass="112348" checksum="091688BA5BD4F98B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2B7</accession>
    <name>A0A2I2G2B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_363528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702307.1">
        <property type="nucleotide sequence ID" value="XM_024844580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2B7"/>
    <dbReference type="GeneID" id="36552280"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363528"/>
    <dbReference type="OrthoDB" id="3432594at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="49" mass="5818" checksum="003807A454C19539" modified="2018-02-28" version="1" fragment="single">KKIGSVLYPVVISRPDIVKNYEILAEYMAKPYLNYMNIVNHLILFIYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Q4</accession>
    <name>A0A2I2G2Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_438873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702462.1">
        <property type="nucleotide sequence ID" value="XM_024849704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Q4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2Q4"/>
    <dbReference type="GeneID" id="36557403"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438873"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="261" mass="29768" checksum="37DBCDAB1F7E9918" modified="2018-02-28" version="1">MPQNEYVERWQKLHGKRFDADEKARKKQAREGHKASKDAQNLRGLRAKLHQQQRHKEKIQMRKRIKAQEEKNVKSNTEAADLSSAVPHYLLDRSEATNAKALSSAIKDKRNEKAAKFAVPIPKVRGISEEEMFKVVNTGKKTHKKAWKRMITKPTFVGQDFTRQNVKYERFIRPMGLRYKKANVTHPKLGVTIQVPILNVQKNPNNPLYTRLGVLSRGTIIEVNVSDLGMVTTSGKVVWGKWAQVTNNPENDGCVNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2S2</accession>
    <name>A0A2I2G2S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_438884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702485.1">
        <property type="nucleotide sequence ID" value="XM_024849709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2S2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2S2"/>
    <dbReference type="GeneID" id="36557408"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438884"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="209"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="785"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="813" mass="91821" checksum="7C3A9FD378F0A6DB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Y3</accession>
    <name>A0A2I2G2Y3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_448879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702529.1">
        <property type="nucleotide sequence ID" value="XM_024851001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Y3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2Y3"/>
    <dbReference type="GeneID" id="36558700"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448879"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000014">
        <property type="entry name" value="Translation initiation factor eIF-2B alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000002">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="332" mass="35687" checksum="ED03160D9391A538" modified="2018-02-28" version="1">MAAADSSSTPANKPFDIVATYNDLLRSDPDLTMPIAAIEALVLLLTHSPSSTISETLDLLEKSTAHLKKSIPNPIGLSAGTDLFQRYLITTLQRPGQLGPAGDFNAIRAHLLSNGRLFIRRAKESRDKIAGFGRGFVRDGSTVLTNGGSRVVASLLQQAADEKGGPSAVRFRVIYVLSDSAEPEGMETVRALREKGVPVSTIPESAVAYALGKTDTVIVGAEGVVENGGIVSRMGTYQIGLLAKAMGKPFYVVAESHKFVRLYPLGQYDLPIEQHVIDFKTEEDITDGDKQQLAHSSEVVDYTPPHLISALITDSGVLTPSAVSEELIKIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G368</accession>
    <name>A0A2I2G368_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tse2 ADP-ribosyltransferase toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702628.1">
        <property type="nucleotide sequence ID" value="XM_024849742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G368"/>
    <dbReference type="GeneID" id="36557441"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439017"/>
    <dbReference type="OrthoDB" id="10266325at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041018">
        <property type="entry name" value="ADPRTs_Tse2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18648">
        <property type="entry name" value="ADPRTs_Tse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tse2 ADP-ribosyltransferase toxin" evidence="1">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="196" mass="22781" checksum="522BBDF71720BA17" modified="2018-02-28" version="1">MFKRIIHRPAVRGNNILKNRCNFSLVSVHSTFPATLYRLQFKRESQLYDKKQQQGDSEVDDAVNVSQDGLIYPEVSESISNGALFMPNTFFMQELTRMSFDYYLDNLADSQPSADPHLLCIPKDTPIPRTLILLRERNIRSRFSLQPSFPMSLNDLNSALTDFYAKYGTPTPAEKWLVEHEYHKSSDDSKEDWMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3S0</accession>
    <name>A0A2I2G3S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear pore complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_385264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702822.1">
        <property type="nucleotide sequence ID" value="XM_024845715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3S0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3S0"/>
    <dbReference type="GeneID" id="36553414"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385264"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000725">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="354" mass="38361" checksum="3AE5BD015137DBC3" modified="2018-02-28" version="1">MASNQFTVASPPSDAISALKFSPDPNSTRFVVSSWDKNVYLYELRDENGNVGEGKLLQTFEHRAPVLDVCFGANEDEIYTAGLDWDVKKIDIGSSTQTVLSSHDAGVRSVVYSKEHSLVISASWDSTLHVHRTDGTNTIPAIIPLPSKPFSMSLTATKLVVAMASRALNIYDLKALALLTAQAEGTVPNKVEVEPWQRRESSLKFMTRSVACMPDDAGYASSSIEGRVAVEWFDPSAESQARKYAFKCHRQTADDVDVVFPVNSLSFHPVHGTFASGGGDGVVALWDGIAKRRIRQYQKYPSSVAAVDFSSNGKYLAVAISPGFEDGKDDVAEGAVAIYVRELGETEAKGKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4M4</accession>
    <name>A0A2I2G4M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_385797</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703124.1">
        <property type="nucleotide sequence ID" value="XM_024845745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4M4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4M4"/>
    <dbReference type="GeneID" id="36553444"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385797"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="334"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="969"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="980"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116580" checksum="37B1EBD2C6BE1B09" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G510</accession>
    <name>A0A2I2G510_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_201600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703259.1">
        <property type="nucleotide sequence ID" value="XM_024842763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G510"/>
    <dbReference type="GeneID" id="36550461"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_201600"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="152" mass="16661" checksum="FB362A7DCE9BD25A" modified="2018-02-28" version="1">MYGSIASHCIICSEFSCNGSVGRLSSLVRISLQSFASSRHFVLFIERGAFRIASRKEPGCNGNCDLYLSMPTLRSNDDKAGPRPDAGSCPYQGASNGVIHSKSGTPFVDTFHRVHRSIPIISLFRYPFLATRAVDGRKKRPFLGTSFSNKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G537</accession>
    <name>A0A2I2G537_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_456668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703293.1">
        <property type="nucleotide sequence ID" value="XM_024851642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G537"/>
    <dbReference type="STRING" id="1392250.A0A2I2G537"/>
    <dbReference type="GeneID" id="36559341"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456668"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="350" mass="36947" checksum="F39E87C363B239AC" modified="2018-02-28" version="1">MAIPSTQTAAVLPPAGATAKASLQIKHDHPVPSPAEGEILVKLEFSGLCHSDVHSVRGETPMLTDVAGHEGVGKVVKVGSGVNEQDWLGTRVGIRWLYSSCLKCEICAINNTACPYQKNAGANVPGTFQQYLISPAVHVTRIPSQLEPDVAAPLLCAGIAMYSSIMKTKTRPGDWLVLPGAGGGLGHMGVQIAAKKGLRVIAVDSGEKKKQLCLSLGAASFLDYKVDDIETEVKKLTSGLGAHAVICTANSEPAYTQSMRLLRSLGVLVCVGIPSVPFRLPATPFDMIVKGLTIVGNSAGTAKEMDALMEMAVAGDVTAHIECFEFDKIDEVLQRLGRSEIEGRAVVKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5M0</accession>
    <name>A0A2I2G5M0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_359669</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703480.1">
        <property type="nucleotide sequence ID" value="XM_024844369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5M0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5M0"/>
    <dbReference type="GeneID" id="36552069"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359669"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB48178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="324" mass="36060" checksum="1801A4F1DCC9907E" modified="2018-02-28" version="1">MALGRTFKLNTGYEIPAVGLGTWQSKPNEVKQAVAAALKGGYRHIDAASVYGNEREVGDGIKASGVPRRDIFLTSKLWNTDHNPENVEAAVDRSLSDLQTDYLDLYLIHWPVAFRHSTTTIQPVDEKTGLIDVIDVPIKDTWTALEALVAKGKVRSIGVSNFTKEKIEELLKTAKIQPAVNQIEAHPFLQQRDLLEWSKQKGIVVTGYSPLGNNIYNIPRAVDDPLVIETAKSLGKTPAQILVSWAVQRGTVVLPKSVTPERIQSNFEDFVLPEDAFQAIQSLERHQRMNFPARLGVDIFGEVGEESARKSALDWAEQQKKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5N4</accession>
    <name>A0A2I2G5N4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_476830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703489.1">
        <property type="nucleotide sequence ID" value="XM_024853385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5N4"/>
    <dbReference type="GeneID" id="36561083"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476830"/>
    <dbReference type="OrthoDB" id="4486134at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="165" mass="17529" checksum="8228906B0255A8BC" modified="2018-02-28" version="1">MSQPIVHRPKTPTLQPNTLQALHPSVLPEYADAPSDSSASTSECPCCAPSPLPDLEALGEAIPECTLDTLGLASTPEGQFQASVSFQPTTEFSTQAVATVPHNKQAKGHCDFLTAVSRKTIRDGLTWLEATVTRGGIPVATATALYDKIHSDTMDDAQVQEASQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5T9</accession>
    <name>A0A2I2G5T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_456819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703515.1">
        <property type="nucleotide sequence ID" value="XM_024851652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5T9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5T9"/>
    <dbReference type="GeneID" id="36559351"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456819"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="145"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="439" mass="50159" checksum="750D9F855DFBAA74" modified="2018-02-28" version="1">METTASIIAVIQLTGIIVKLCGGYIREVKDARDEVLNLQRAGKFLPVSSRLASDITDCLADLQALETKLDPGKGKSLIRKVGLRALKWPLRKIEVEVDQTIAENNDLRKLEASTNAGFKLFSDRDEIECLQGTRTELLQEIMEWGMAGTGKSIISRTVSSFFFKRGEGDRGNTKKFFPTLASHLVLWNHELRPEITSKSLREQFEKLLLQPLLSLDQLSRQPQTTVIVVDALDECEHDRDTRNIVRLLPLLQNMKSVRLRVFLTSRPELPIHFGFSDIGSNEYLDLALHEIPEKVTERDIQLFLQHRFAQIKRDKRVIQDWPSDEAIQELVRISLPLFISAATVCRYIEISKLEPKLRLAELLKDQRKYLLQEFQDIVGVIILLEAPLYINTLLIFLGMEADRISNRLESFQSVLSIPDDLDQPLFTQGHLQAHRAWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6W6</accession>
    <name>A0A2I2G6W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_464315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703907.1">
        <property type="nucleotide sequence ID" value="XM_024852234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6W6"/>
    <dbReference type="GeneID" id="36559932"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464315"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF201">
        <property type="entry name" value="MFS AFLATOXIN EFFLUX PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014178216" evidence="8">
        <location>
            <begin position="22"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="515" mass="54750" checksum="6CF0A5996FCA8BB4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6Z5</accession>
    <name>A0A2I2G6Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_446510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703948.1">
        <property type="nucleotide sequence ID" value="XM_024850803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6Z5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6Z5"/>
    <dbReference type="GeneID" id="36558502"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446510"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014153193" evidence="4">
        <location>
            <begin position="21"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="52"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="399"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="445" mass="49405" checksum="8521F7C82995BF48" modified="2018-02-28" version="1">MHFQLLSSAVLLGALSTASAESKFNPLEHLTGIAPYYYPKHPPLDGAAPQGCNVTRAAYLVRHAAIYANDFDYESYLEPFIDKLRNTSQDWSSVGGLQFLSNWSAPVDEEHLEKITRVGYQEATSLGSTLRKRYSGLKAPEKVWSSSADRTVRSANGFIAGYTNNKNGSVHLQQVEESEDTGADSLTPYKSCPAYSGSYGSDQSQEWVDRYTKPIIERLNSQASTFNFTVSDVVAMFELCGYETVIRGSSGFCSQNLFSQDDWLAFEYGEDVRYFHNAGYGRDVTPRIGYPWVKASADLLDDSASKQDLYVSFTHREMPPMVITALGLYNNSAFSGANNINGTMPTDRINYNRAWVSSRILPFLTNIAIERMQCDSFGYDEGDYYRVLVNAGPQPLVECRDGPGDSCSDGKFKDFVKELGGLYGGDFDSFCGTSSNISQRLSIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Q6</accession>
    <name>A0A2I2G7Q6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Urea carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_383300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704207.1">
        <property type="nucleotide sequence ID" value="XM_024845637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Q6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7Q6"/>
    <dbReference type="GeneID" id="36553336"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383300"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014084">
        <property type="entry name" value="Urea_COase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02712">
        <property type="entry name" value="urea_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="3"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="121"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="1154"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB48905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1236" mass="135397" checksum="B2F60F6FD1FE7F98" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8D5</accession>
    <name>A0A2I2G8D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_383754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704436.1">
        <property type="nucleotide sequence ID" value="XM_024845657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8D5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8D5"/>
    <dbReference type="GeneID" id="36553356"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383754"/>
    <dbReference type="OrthoDB" id="4829at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="306" mass="33436" checksum="EF48D79ED3CF283B" modified="2018-02-28" version="1">MDAYTPPEVAELVSRAGATKGNMRLDKVFFSAFSAGCLLAFACGTVLSTNTASWFQDNAPGLIRTIGALVFPYGLCIIVLTGADLCTGSFMYTTVAALQRRLSWPKMLLHWFVTFWGNLAGSLFIVAIIFGYGETFSADPYKSQVISFATKKQLTPDFHMIFLRGIGCNWLVCLGCFLGLQGRELSSKIIGIWLPIFAFVSLGFDHVVANMTFIPMAIWLKAPGLNIGLYIWKGIIPTLLGNIVGGGLFVGTYYWYMYLVKEETITLTGLRKGQDKSEASSFAPRGKEDVEASAGAMDSGFKINSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G906</accession>
    <name>A0A2I2G906_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_358715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704667.1">
        <property type="nucleotide sequence ID" value="XM_024844311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G906"/>
    <dbReference type="STRING" id="1392250.A0A2I2G906"/>
    <dbReference type="GeneID" id="36552011"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358715"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="74"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="447" mass="49396" checksum="6C60D96E1D5F0089" modified="2018-02-28" version="1">MSTHKPKFPNADPTTEDDKPDTLHREFTIDEENNKKLARDEAGVLSRAGGDYSGAQKKTDPVEISLVRKLDIWIMPTLWVMYWLNYLDRNAIALARLNDLEEDLGLSSSQYQTCVSILFVGYLLGQVPSNMILTRVRPSLYMAGFMALWAVVSALTALAKDFKGLLLVRFFLGVSEAPYYPGALYMLSIFYTRKEIATRISILYTGNILATAFAGLIAAGIFHGMDDLAGITGWQWLFILQGAVTFVVAVFSIFTLPDDPLKTRWLTPEERELAHARILADTVGARVQSSTFAGLKEAARDPRLWLFAFMQHMHLAANGFKNFFPTAVETLGFNTTITLVLTCPPYLIAGLISVGWSWSSGKYNERTWHITVAKAIAIFGFVLGCATLNTGARYFAMVVFAIGTYAVNSIVLGWVSSTCGQTKEKKASALAIVNTTANVSFIWTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G941</accession>
    <name>A0A2I2G941_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_456043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704704.1">
        <property type="nucleotide sequence ID" value="XM_024851592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G941"/>
    <dbReference type="STRING" id="1392250.A0A2I2G941"/>
    <dbReference type="GeneID" id="36559291"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456043"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="73"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="552" mass="60853" checksum="AA449BD15C1E0F9F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G987</accession>
    <name>A0A2I2G987_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_184338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704746.1">
        <property type="nucleotide sequence ID" value="XM_024842681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G987"/>
    <dbReference type="GeneID" id="36550379"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_184338"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="73" mass="8048" checksum="FDD4B98BC3D1987D" modified="2018-02-28" version="1">MVSFLLGYEGLPVIGGQDTRQDSRRDTRRRRGHRKSQFAVSWLFPSLSFSLSLSPSPMILGPAVDGGQGSKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Q0</accession>
    <name>A0A2I2G9Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_510138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704911.1">
        <property type="nucleotide sequence ID" value="XM_024854747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Q0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Q0"/>
    <dbReference type="GeneID" id="36562453"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510138"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="559" mass="63071" checksum="D62854B65C1716F1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAD6</accession>
    <name>A0A2I2GAD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_358567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705138.1">
        <property type="nucleotide sequence ID" value="XM_024844304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAD6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAD6"/>
    <dbReference type="GeneID" id="36552004"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358567"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="297" mass="31373" checksum="0E4AEF89CBDE4B1C" modified="2018-02-28" version="1">MSLNITSLFDVQGRVAVVTGGSSGLGFMICRGLVTNGAKVYLVALPSDPIDAKVVELNALGQKSGGKAEGISCDISSKDAIDNLVAQVSKHETHLDMLISNAGIRRDPPISCNVLTASLTQLQQSMQSSRPTDWEDTFRTNTTAHYFLSVAFLPLLAAASEKTMPDGKSGKDHGRGVVLLTSSCASMHNVTNVDLTSYATSKAATDHLVRLLAAKFSRFYVRVVGINPGFVPSQMNPVGQAGNIFRGLFDQVPARRAGEDGDIAGTVLYLVSRAGAYVDGISLCVDGGRILLANGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAL4</accession>
    <name>A0A2I2GAL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_473491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705212.1">
        <property type="nucleotide sequence ID" value="XM_024853047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAL4"/>
    <dbReference type="GeneID" id="36560745"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473491"/>
    <dbReference type="OrthoDB" id="1161823at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="155" mass="16990" checksum="1221AA5A283704F1" modified="2018-02-28" version="1">MSTDPPRNEMVYLPGVLSPNRSFGVFRKVLHTGLYSQFVAMEVPVNGEIGDEKHTVDQVLLFTSGIGKAIVAGKEQEVKQGDTVIVPAGTQHQFLNVGSAPLEVVTIYSPAEHHPQTVHQTKAEGDEKEESGQDEPAEWSQRSKEENEKLGLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBU7</accession>
    <name>A0A2I2GBU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_380893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705619.1">
        <property type="nucleotide sequence ID" value="XM_024845545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBU7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBU7"/>
    <dbReference type="GeneID" id="36553244"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_380893"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="550" mass="59423" checksum="271B16E9BE20323E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBX0</accession>
    <name>A0A2I2GBX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_405370</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705667.1">
        <property type="nucleotide sequence ID" value="XM_024846582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBX0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBX0"/>
    <dbReference type="GeneID" id="36554281"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405370"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF141">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014181174" evidence="16">
        <location>
            <begin position="23"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="18">
        <location>
            <begin position="115"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB50365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="438" mass="48304" checksum="8907493B7A29885C" modified="2018-02-28" version="1">MRLQRNLLLYGFLLITLVVCSAAKDPDLYSFPQCALSCGEQVNCAPDDTRCACSDRLFEGSLGTCVAANCTIKEQFVTKRLRAKECGFSEHEGRPAVEAATLVPLILTSILFICRIFAKAIHLGGGWGWDDTTITVAYALAVEIFIVNIYMIHHGFGMNMWDIIPFSNITMVYKLFYVLVLSYKIQISLAKISVCLFLLRIFQSALFRHITYTVIALNTAIGITWVLCDSLQCIPVHLAWKGWAGEEQGKCIDFITVTLTNALVNIFVDFAMVAAPVYEITKLQLTKKKKVGVGLMFAMGLLLTVVAIIRVVVFWNNRWSDNQTAQLQPIVHWSVIEVQIAVLCACLPATRALIGHFMPELISVYGKKSYATNGAPLSSHAYPPGSNAKGEIAKTMTYSVNYTSRAQRDDSGSSVELVEVDQESLEGGKVNGRGGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC19</accession>
    <name>A0A2I2GC19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA exonuclease 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribosome biogenesis protein NOP53</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_454950</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705724.1">
        <property type="nucleotide sequence ID" value="XM_024851490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC19"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC19"/>
    <dbReference type="GeneID" id="36559189"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454950"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Exonuclease" evidence="14">
        <location>
            <begin position="531"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="183"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="431"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB50422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="729" mass="82854" checksum="0B88948E0062C1B1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCG4</accession>
    <name>A0A2I2GCG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_148265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705864.1">
        <property type="nucleotide sequence ID" value="XM_024842505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCG4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCG4"/>
    <dbReference type="GeneID" id="36550202"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_148265"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="186" mass="20118" checksum="F67E14EB65846030" modified="2018-02-28" version="1">MPALRFVRSVWESFRATSGLEPRLLNNLRVTAARPGVVNFELDIQKEHTNRLSILHGGTIASMVDLGGSLAVASRGLFATGVSTDLNVTYLNSGGKVGDKILAEVNCDKCSFPPFALSIIAVDAPELILNTIDPYVAVGKTLAYTSIKFLNSKGEVVARGSHTKYVARAWKDPQNIVEELSESDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCI1</accession>
    <name>A0A2I2GCI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_381450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705882.1">
        <property type="nucleotide sequence ID" value="XM_024845571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCI1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCI1"/>
    <dbReference type="GeneID" id="36553270"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381450"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="821"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="949"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="286"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB50580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119642" checksum="C3FC6892F1C1F1BA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE70</accession>
    <name>A0A2I2GE70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_493417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706487.1">
        <property type="nucleotide sequence ID" value="XM_024854045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE70"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE70"/>
    <dbReference type="GeneID" id="36561750"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_493417"/>
    <dbReference type="OrthoDB" id="4295718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014115668" evidence="1">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="245" mass="27939" checksum="4531988B22BAB7BF" modified="2018-02-28" version="1">MRLVLLAVFAYAVTLVSSYGVAGTYERVLFWHAFEIDIEIHGGRPRTIGTGCASAMRVARCNFNQFITCIDENRSPPITRDVKGMQVDEMSDLLYRNGNSGTYIMKNVVDGIPEAPGQFPKLIDQVSKFIRDNRAQIESTSPQRLKYARSAMRRAHFVRAASYSDSSKVLLQKNLGVTAEMKKKIMGGRQQTEYWFVDWEATARKYPDKEVDQFRRDIEKHYDIKHWRNVAALTEALSRVGGCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GET2</accession>
    <name>A0A2I2GET2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_436410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706696.1">
        <property type="nucleotide sequence ID" value="XM_024849151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GET2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GET2"/>
    <dbReference type="GeneID" id="36556850"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436410"/>
    <dbReference type="OrthoDB" id="5175656at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014117085" description="Dipeptidase domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57854" checksum="014E68C5C39CADDD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHP4</accession>
    <name>A0A2I2GHP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uroporphyrin III methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_378161</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707704.1">
        <property type="nucleotide sequence ID" value="XM_024845435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHP4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHP4"/>
    <dbReference type="GeneID" id="36553135"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378161"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 12 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="15">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="14">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="284"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB52402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="558" mass="60981" checksum="F064D95DF0B74B8A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI06</accession>
    <name>A0A2I2GI06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taurine catabolism dioxygenase TauD, TfdA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_453862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707818.1">
        <property type="nucleotide sequence ID" value="XM_024851395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI06"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI06"/>
    <dbReference type="GeneID" id="36559094"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453862"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="407" mass="45822" checksum="D16DAF5B7E60DD36" modified="2018-02-28" version="1">MTAPIQIPTPNFTLESFDLPSTNQRILGPPHPPNTAIPLALRPASTIPTLDTIIHDIQTLQHNQLFTKYLSRHGTLLFRGLPIHNASDFSRFAHAFGYRPHEIIGIVVDRPVLAPNVAPANESPKEILIYNHNESPQVPHAPEYIFFYGHRSPADGGETPISSSLELFQRAQRELPTFIAELADKGILSKVTYTVTPQYKGGATLRQAFGKHILDSDDEDTQRRKVEAQIKRYNRGEYTTWEWTDEGTLVLTHRLPAIRTQVGTNLPALFTGLAAYYRNVKVNGRGNAAQQVYGDGTAIPEEYLERLARITDEIRVLHRWEEGDVLVYDNVVAQHGREPWRGEQADRVVMASLFDGEVPGVHELLENHKNSIIGLVVEFVVAIDEARVRFTDDAFFLLLFLPLYNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIJ0</accession>
    <name>A0A2I2GIJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_403139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708008.1">
        <property type="nucleotide sequence ID" value="XM_024846461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIJ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIJ0"/>
    <dbReference type="GeneID" id="36554160"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403139"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="536" mass="58426" checksum="82634F1373E30505" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIY1</accession>
    <name>A0A2I2GIY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_434569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708146.1">
        <property type="nucleotide sequence ID" value="XM_024848742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIY1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIY1"/>
    <dbReference type="GeneID" id="36556441"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434569"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="372" mass="41301" checksum="766AB616B360C604" modified="2018-02-28" version="1">MSDSLYGAPRPKSTSKSDAPSASNLAFTTTLSSLISQDTKGSSRGGRPRPARTGKSDIFAQHNKGAQKRAAADLRDDEHGVFQQHQRTADIGGVDAAALHRSKRRMQEKARVYEELKSGAYLAADSDDDDDVYKGGGEAGGADAYLARLRRKEREGLVDFDRKWADAERAKGSGSDEEEDGDEEDDENASVVSYEDELGRTRRGTRAEAARAARVKAEESGERSNMQERWRPSRPENLIYGETVQAEAFNPSAAAASQMSYLATRRDRSATPPGESHYDADAEVRNRGTGFYAFSKDENVRRQQMEELVSARDETQREREARQKRRAEREQIKDERRKKIGELRSKRRAEMFLAGLGNVGDWSGSTPVEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ96</accession>
    <name>A0A2I2GJ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_507673</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708250.1">
        <property type="nucleotide sequence ID" value="XM_024854504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ96"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ96"/>
    <dbReference type="GeneID" id="36562210"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507673"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="451"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="506"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB52948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="629" mass="67784" checksum="59DA739AEA3793ED" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJI2</accession>
    <name>A0A2I2GJI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_379412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708341.1">
        <property type="nucleotide sequence ID" value="XM_024845483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJI2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJI2"/>
    <dbReference type="GeneID" id="36553182"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379412"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="624" mass="69959" checksum="7CB88282B56DE6DF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJU2</accession>
    <name>A0A2I2GJU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_124144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708442.1">
        <property type="nucleotide sequence ID" value="XM_024842377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJU2"/>
    <dbReference type="GeneID" id="36550072"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_124144"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="66" mass="7658" checksum="32ADF1FAE3FE7587" modified="2018-02-28" version="1">MKSCLPIKWPRYHRRKTPDANAKNTQMPMQILIYTNKSHHNHDVIILSTMSITSDINRSGYHPGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJZ1</accession>
    <name>A0A2I2GJZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_462950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708481.1">
        <property type="nucleotide sequence ID" value="XM_024852128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJZ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJZ1"/>
    <dbReference type="GeneID" id="36559826"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462950"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="471" mass="52103" checksum="C471A6D582AABDFB" modified="2018-02-28" version="1">MASYALSPAHRDQMEKTLVETDPEIAQIMEKEIQRQRESVVLIASENFTSHAVFNALGSPMSNKYSEGYPGARYYGGNQHIDAIELTCQARALKAFNLDSEKWGVNVQCLSGSPANLQVYQALMRPHDRLMGLDLPHGGHLSHGYQTPSRKISAVSTYFETFPYRVNLETGIIDYDQLEANAEMYRPKCLVAGTSAYCRLIDYQRMRKIADKVGAYLIVDMAHISGLIAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGVRSTNPKTGEDIMYDLEGPINFSVFPGHQGGPHNHTITALAVALKQVDTPEFKQYQEQVIKNAKALEVEFKQLGHKLVSDGTDSHMVLVDLRNKSLDGARVEAVLEQINIACNKNSIPGDKSALTPCGIRIGAPAMTTRGMGEEDFKRIARYIDQTIVICKAVQGELPKEANKLKDFKAKVASETVPEILALRKEVAEWASTFPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK00</accession>
    <name>A0A2I2GK00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_423971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708505.1">
        <property type="nucleotide sequence ID" value="XM_024847539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK00"/>
    <dbReference type="GeneID" id="36555238"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423971"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="161" mass="17508" checksum="C2295CB397F74556" modified="2018-02-28" version="1">MSTRKRKQEAEEPEELQALPSDESGSEEEEYEESDLGSDVGEEDEEAASEEDELEDEGEEEEAPPEKAPAPKKRKTAPAPEEEEGEDKEVKENGKDTSKNGAADDAEADEEEEEPEPEEEEEEEPAETSKTSGPAAAAAKAKGDTVPKEPEVDIGDEDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK48</accession>
    <name>A0A2I2GK48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_454385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708552.1">
        <property type="nucleotide sequence ID" value="XM_024851429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK48"/>
    <dbReference type="GeneID" id="36559128"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454385"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="426" mass="49459" checksum="EF11607C3FF9D0A8" modified="2018-02-28" version="1">MSSFSQLITNVKKARAAFNRGRSRSDAKRNNHTFRHSVFPSSLSSTSVVEPINLLPTSSPWDLLPVELQIKIFAHCGVADFLPLKLVCRSFFQLLTSQEHWITRQYLRQRRHGTLPSPIDSERTYSRHPEDDVVLLSDLFPPISSAKGGHLYTFRYIHSLRRRQKLCSKLCYYLADRVVDRFMRCEPGFVKSRFPSRNERSDFMKRAIGTIWFYLTPLMYYTLYFLETYTLARREQTNTLLRDFEAGRLPVRLPPDARKSIYRDLQVQILQSPPFTDTATLVSTHHCMQLLVSYLQYTVPPDEPGPADDSWISSLLTVSPFMRVLEYFSAEIGDGGSQRMQRKEFMHNFHNDITSNEKDDMNSRVFECAPHIHVHGSTQDVWFDVATQELTSRRAMQHKPELVLVWDGLPIVFGCQYCRDSAGWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKH5</accession>
    <name>A0A2I2GKH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_129002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708682.1">
        <property type="nucleotide sequence ID" value="XM_024842396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKH5"/>
    <dbReference type="GeneID" id="36550091"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_129002"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="76" mass="8814" checksum="77FBE3BEB1F597F9" modified="2018-02-28" version="1">MFYPWYSIDLGLASLSWAALSGLGICFVSVFEWFARVQGSALFRMRIRPPCSVMHGWDRRCLLAAAALLYWDWPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKV9</accession>
    <name>A0A2I2GKV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_473339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708781.1">
        <property type="nucleotide sequence ID" value="XM_024853027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKV9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKV9"/>
    <dbReference type="GeneID" id="36560725"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473339"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="293" mass="32661" checksum="A3D36B39BE47A917" modified="2018-02-28" version="1">MNFPEPHIQPPQGSHTHTAILLHGRGSDGSEFAEDFFSSTTSNSQNLADCLPTWRWVFPTSRERWDSRFQEDMCAWFEAYSLTDIQELQELQIEGLRESVSYILTLLESEIELLDGKISHLYLGGISQGMATALWTLICADGRLPGQLGGFLGFCGWLPFAHQLEDLLLPSNEAKSLIPHPKGARIQSLVSHLFADTIGKPEVPQGDESGDTTLLSIPVFLSHGTDDAWVPVQLGRQAGRILRQISVDVEWHEFEGAEGDGHWIKEPEGFDQIVGFVERATQRIGKDPAKVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLE0</accession>
    <name>A0A2I2GLE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_396283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708996.1">
        <property type="nucleotide sequence ID" value="XM_024846108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLE0"/>
    <dbReference type="GeneID" id="36553807"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396283"/>
    <dbReference type="OrthoDB" id="2017946at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023213152" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023213153" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="234"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="466" mass="49088" checksum="3AF06C53FE00546B" modified="2018-02-28" version="1">MTFTVQPTATMATFTRMMKGQVRNYSAPLDMAIPAAKQKYIPSSGSYPKGFNVSGTHVGVKASNTKFPDLALISSETPCSAAAVFTTNKFQAAPVQVSRDILKNRQGQGIQSVVINSGCANAVTGKGGLEDAVSMGKTVDECNGLNEPSTLVMSTGVIGQRLPISKILDKIPAGHANLSSTHDAWLSTARAICTTDTFPKLLSRTFTLPSSPGRTYSLAGMTKGAGMIHPNMATLLGVLCTDAPIEPSALQSLLKHSIGRSFNSISIDGDTSTNDTIAILANGAAGGAPISSSSSDDYAAMQDVLTSFSQSLSQLVVRDGEGATKFVTVRVQNSPDYESARLIASTIARSPLVKTALYGKDANWGRILCAIGYTQGVAPGTVVPEQTSVSFKPVDGSPILKLLVNGEPEQVDEDRASVILQEEDLEIVVDLGGGEKGQQGLGGEEAVYWFCDFSHEYVTINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLG1</accession>
    <name>A0A2I2GLG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_396322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709014.1">
        <property type="nucleotide sequence ID" value="XM_024846112.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GLG1"/>
    <dbReference type="GeneID" id="36553811"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396322"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1258"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1285"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1411"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="114"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="801"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB53712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1444" mass="162274" checksum="37FF968B5309D1D1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLH7</accession>
    <name>A0A2I2GLH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_346333</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709034.1">
        <property type="nucleotide sequence ID" value="XM_024843561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLH7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLH7"/>
    <dbReference type="GeneID" id="36551261"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346333"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="80"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="422"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB53732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="807" mass="91561" checksum="E5F477B955D2D2F4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLL2</accession>
    <name>A0A2I2GLL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_346545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709068.1">
        <property type="nucleotide sequence ID" value="XM_024843570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLL2"/>
    <dbReference type="GeneID" id="36551270"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346545"/>
    <dbReference type="OrthoDB" id="4524870at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014150369" evidence="1">
        <location>
            <begin position="30"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="270" mass="29334" checksum="76F03AC360FEF904" modified="2018-02-28" version="1">MAMQSGRGSKLRPYLTLLIFATIFQSGLAQLCSFWDGGCVDPLAQTAVSFGFPPLFLDDINLYYGFDANSRGKGHEPMTKASFWLGYAARRIDNSVIDRNRTSEIAMRIGNLTGTPAGDNNGCDGVWGPQCSNNLKSAFKGAIYDLSKKGDYYSYPLDTVISQMLINPPSLANCPPPFFDVQTFPVQPFGQETDTDLSATLKTSGTSESPWKTWFIDNMTSSQQAEQVAVAIISRGPSYNSAPPRSKDDVQIELVCVQAPSTGSSSTQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLM3</accession>
    <name>A0A2I2GLM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_460130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709076.1">
        <property type="nucleotide sequence ID" value="XM_024851912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLM3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLM3"/>
    <dbReference type="GeneID" id="36559610"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460130"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="186"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="395" mass="44565" checksum="9548B5C9F52CA4A3" modified="2018-02-28" version="1">MNGYSGHGLDEDAFGEKPSSKGGLQTFDAFPKTKPSYTTPSRRGGQWTVLILLVCSIFSFSEFRTWLKGTENHHFSVEKGVSHDLQLNLDIVVQMPCQALHVNIQDAAGDRILAGELLKKDDTSWKLWMDKHNYGSGAYQTLSHEDAYRLSQQEEDAHVHHVLGEVRRNPRKKFPKGPKLRRGDSVDSCRIYGSLEGNKVQGDFHITARGHGYRDFAPHLDHDTFNFTHMITELSFGPHYPTLLNPLDKTIASTESHYYKFQYFLSVVPTIYSKGSRALDIFSGAPPSQQTHSNSKNLVFTNQYAATTQADELPESPFFVPGIFFKYNIEPVLLMISEERTSFLSLLIRLVNTVSGVIVTGGWLYQISSWASELLGRRRARKSEGVLTGRHHAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLQ8</accession>
    <name>A0A2I2GLQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bicupin, oxalate decarboxylase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_345271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709122.1">
        <property type="nucleotide sequence ID" value="XM_024843505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLQ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLQ8"/>
    <dbReference type="GeneID" id="36551205"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_345271"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014150367" evidence="5">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="255"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="407" mass="45044" checksum="6E494BAAA0E15EF3" modified="2018-02-28" version="1">MKPTILFHLIAAVPCILGATTGKRSEFEDGQPIDDTGKGASILGGTNPPLDLQNPDNLGRPTTDNGFVPNLKWSFSDSKTKIFPGGWTREQVIQDLPASHDIASAQQHLSKGAIRELHWHRVAEWGFLYAGSLLLSGVDEDGGFTTQKLEQGDIWYFPKGVAHTVQGLDDENEYILVFDDGDFEKVGTTFMISDWITHTPRDILAKNFVVDPSVFDAVPAKFPYILNGSVSSEAKHTPQGTLTGNSSYVYRTYQHPAEPVPGSGGVLRKIDSRNFPVSKTIAASVVELEPRGLRELHWHPNAEEWLYFHRGQARATVFIGDSKARTFDFRAGDTGVFPEDSGHYIENTSDTEKLVWIEIYKSDRVADISLAQWLALTPADVVAQTLKVDVEVVKHIKKEKQVFVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLS3</accession>
    <name>A0A2I2GLS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_469311</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709124.1">
        <property type="nucleotide sequence ID" value="XM_024852618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLS3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLS3"/>
    <dbReference type="GeneID" id="36560316"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469311"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000145">
        <property type="entry name" value="Class III chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014111489" description="chitinase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="30"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB53822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="38736" checksum="C67280F8B10EC4C0" modified="2018-02-28" version="1">MSPINAIKLLSIVFPLLQGVQAGIDLNAGNNVAVYWGQNSYGQSTGEYVQQRLSYYCQNSNIDVFQISFLTRINGAGGVPEVNFANAGDNCTTFPGTSLLNCPQIAEDIQTCQKAGKTILLSIGGATYTEGGFTSESAAIAGAQLLWEMFGPVSNSSRSRPFGNAVIDGFDLDFEATVNNMPAFANQLRTLYAADSSKSYYLTAAPQCPYPDLANNPMLDGAVSFDAIWIQFYNNYCGLQSYVPGSSTQNNFNFATWDNWAKTSSRNKNVKVFLGIPGNTRAAGSGYQPLDRVKEIIGYVKGFSSFGGVMIWDASQVFANGGFLSGVKGAVGASVVEGTVSHGASENEGFLTLAKAEKPLGTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM21</accession>
    <name>A0A2I2GM21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_346082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709229.1">
        <property type="nucleotide sequence ID" value="XM_024843545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM21"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM21"/>
    <dbReference type="GeneID" id="36551245"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346082"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="455" mass="49296" checksum="70663D54E71A5B68" modified="2018-02-28" version="1" fragment="single">GFDVQVNGAVISVPAFRRDYGYVLDGVAILPASWQSAFNTCSSVGQFFGGFLCSWLADRIGRKRSLFCGIVVCTGGIMGEIFSDTRGAFLGSKLVLGVGLGFYLTLGPLMCSEITPVVLRGLSTAGVNLGISLGQLLSNAAIKGFGEREDRWAYAGPFSIQLLFTIVLLLGVSFSPESPWYLVKRDKPEEAKKALRKLWGPDFNVAAKLSTIQLAVEEALQHTETKYLDCFRGTNLLRTGISLGGFVCQHLVGIVFVLGYSTYFFELAGLEQSHSFNLGVGVTACGVLGNFLSWFILNSFGRRRTFIIGMATMTTLLVLIGIMDVIPSNGANWVQASCTVIYAFVYFLTVGAISFVLLGEVSTPLLRAKTTALATAVQAVFGIIMNVIMPYMVNPDEANMKGKVGFVFGGCALVATIGSWVYVPELKGRTFPEIDQMFYSHVPPRKMGQYASVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM24</accession>
    <name>A0A2I2GM24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_344796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709226.1">
        <property type="nucleotide sequence ID" value="XM_024843483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM24"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM24"/>
    <dbReference type="GeneID" id="36551183"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344796"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="351" mass="38538" checksum="EA572F558B57D63D" modified="2018-02-28" version="1">MDLYTTTEDVLKLGIIDPELEEVLKHNPAPAMNFSHPVQTLRSIVSAMEKTSYDTCPKFNTQETTLDIPMRDGHQSNLHIAKPSSSSSNPLVVLIFGGGFIMGSNIQSILWARAIASLYGATVVQPSYRLAPEHKFPTAPNDIWDAVRWITANASTLDVDLTKGFVIGGGSAGGNLSIVTAHRSIKERLSPPITGVLASIPVCVSDEMVPQKYKHLWVSREQNANAPGNPGLDSKSIDGYEAMYAQDFSSEDFSPFNSTVGFSALPRAYVQVAGLDILRDDGVVYAKALEDSGVEVRFDAYPGMPHGHFNLWPGLKQSIRSQEDTIWHVGWLLRREVSREKVAELLSLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMQ2</accession>
    <name>A0A2I2GMQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_397268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709473.1">
        <property type="nucleotide sequence ID" value="XM_024846164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMQ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMQ2"/>
    <dbReference type="GeneID" id="36553863"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397268"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF5">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="145"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="433" mass="47922" checksum="33F5339EAE052239" modified="2018-02-28" version="1">MPSPSNMGSTTPQKKDFTVSIVGGGIGGLSLAVGLLRRNVRVQIYEAAPAFAEIGLGLSIGPAAHRAMPLIDPQIRAIYDSLVTTHADSPGYEAFRQTWFEIVWASGDQEGETLMDLKALPSGQTTLRRADFLEALVGLVPKEIVHFGKRLERLVEGRDGVELRFDDGTEVCADVVVGCDGIKSKVKEAIVPDEAQRPRFSGMYAYRAVLDMEDMVKAVGDQRARVSTMYVGKGAYGISYPIMRAKKVNVGFYILTDTWDHESWVRPAKKEDMRRDASGMGRYMQSLVEYMPDPSQWAIFEHPHISTYCKSRVAILGDAAHASTPHQGAGAGQAIEDAHVLAELLSDPRVSSVGDVEAAFKAYDEIRRPRSQRVVTSSKENAYLLCLCLEGVDDDETKLKETFQKRLRWLWDLDVQGQADQAREKMGEYLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMW4</accession>
    <name>A0A2I2GMW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_344431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709492.1">
        <property type="nucleotide sequence ID" value="XM_024843460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMW4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMW4"/>
    <dbReference type="GeneID" id="36551160"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344431"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051794">
        <property type="entry name" value="PG_Endopeptidase_C40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359:SF3">
        <property type="entry name" value="NLP_P60 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359">
        <property type="entry name" value="PEPTIDOGLYCAN DL-ENDOPEPTIDASE CWLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="36"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="189" mass="20700" checksum="8F05A983A2768EE1" modified="2018-02-28" version="1">MKFTAIIVGSLASSAFARHTFFQAPRNSSKPAVEKPDVGKQILDKAMTAASIPYAWGGGSCDGPSQDQPPYQYGDIGYDCSGLVCWAVCQITGRDLFTEGLRVTSDMYCASEKTLKYKKYPYEDRKAGDAIFFGGECDCADSSSIYHVGLMMDSGDRMWNAPNDRVNKVQENSIASFGDTPCPYVVRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN70</accession>
    <name>A0A2I2GN70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_442440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709627.1">
        <property type="nucleotide sequence ID" value="XM_024850463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN70"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN70"/>
    <dbReference type="GeneID" id="36558162"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442440"/>
    <dbReference type="OrthoDB" id="5411678at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="39473" checksum="119F564B457DCD88" modified="2018-02-28" version="1">MYRYLIRDQTREPPDVLTTSSTSTSSSSSSSSTSSSSSSSTTTQPQPTTTSDAPTTSSAPETSTSTTEDSTTSPVVTSIITQSPTDGTTGPRTLTITSTATSLPTLSTGDSAGSASATGASSATASATSTAAGAAGGSGLSAGGTIAVAVVVPVVSVALIILAALYFWRKWKAKKAAEEERRKEVEEYGFNPNNDPTLPPVMGGSAYEPKDDTSGYRGWGTTSAGRKASTNLSSSAGVGLAMSEAGSAPGYHHAATPSDGTIQYSEGQAAAETEPIGVLGAAPVAAANTRNADIHRGPSNASSAYSAANRSEASEESHMSAARHNSAFYDDNPYYNDMQPQYGAYGDGPYSGNQPVIRDVQARRNTRIENPAVFPRQGNAGIAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNA4</accession>
    <name>A0A2I2GNA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_15117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709659.1">
        <property type="nucleotide sequence ID" value="XM_024842519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNA4"/>
    <dbReference type="GeneID" id="36550216"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_15117"/>
    <dbReference type="OrthoDB" id="4506349at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014178278" evidence="2">
        <location>
            <begin position="22"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="216" mass="22801" checksum="3AB343D3C53EDC0B" modified="2018-02-28" version="1">MTRLNISILAACLSLSALTSALPTKRFDPMSDDDLNPGSAASIAEMSLRSTVDFFDDMEKMWKEDQEEKKQKTNPAAAGARTESSDAVTSAVPLVPMPPTPSQESSPSQESHSSNHPLEINKTSKGETSESYNDGQHEQSVPSPAPSRALSEPKAEEKPKAEEKPQAQEKPSPTTSQPSSSASAAATPSGSVHEVKDNIFSKIPIVGKILSGGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ91</accession>
    <name>A0A2I2GQ91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_374517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710349.1">
        <property type="nucleotide sequence ID" value="XM_024845288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ91"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ91"/>
    <dbReference type="GeneID" id="36552988"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374517"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="853" mass="97546" checksum="F5ADD0FCD743308E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQJ0</accession>
    <name>A0A2I2GQJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_33609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710450.1">
        <property type="nucleotide sequence ID" value="XM_024843380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQJ0"/>
    <dbReference type="GeneID" id="36551080"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_33609"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="163" mass="17958" checksum="7940CC06F7612BB6" modified="2018-02-28" version="1">MSVTSWMDFMYGQAHREPMVPLFGVSPVNLIPSGEDWRGEIPHSDSRTTEGRAEPAHQKVWPRSDISSPRMNHASKTRESCGGSCPRLLEPLGDVIGRPERNVPARQVSKTSLVALNGSRFVRLLAVAHGPYLEVDSQVGCTPGRKYRDWLPSLPKTGVSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQK6</accession>
    <name>A0A2I2GQK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_33911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710452.1">
        <property type="nucleotide sequence ID" value="XM_024843386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQK6"/>
    <dbReference type="GeneID" id="36551086"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_33911"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="141" mass="15696" checksum="5EDA06371F8810B2" modified="2018-02-28" version="1">MIATWDEVILSLLSGMMFNLRVAHSLFLTWSVEPLGPNCPKKGTRPASLITAYQGNLVPLTAREGNKEENVGKAPRNAAIGLQRDQIRRGTALCRPSQREGWRFHRKVVSYQVLQSWHQCAPEQEFSVASETSAGVSRSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQM9</accession>
    <name>A0A2I2GQM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_346828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710488.1">
        <property type="nucleotide sequence ID" value="XM_024843589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQM9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQM9"/>
    <dbReference type="GeneID" id="36551289"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_346828"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="530" mass="60226" checksum="69472AC2C7380432" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQN0</accession>
    <name>A0A2I2GQN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_374748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710487.1">
        <property type="nucleotide sequence ID" value="XM_024845297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQN0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQN0"/>
    <dbReference type="GeneID" id="36552997"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374748"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000002">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="612" mass="66800" checksum="AFBE98D5D15CAD1A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR29</accession>
    <name>A0A2I2GR29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_470735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710623.1">
        <property type="nucleotide sequence ID" value="XM_024852785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR29"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR29"/>
    <dbReference type="GeneID" id="36560483"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470735"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000009">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="78"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="252" mass="27585" checksum="81805FFC7483E7FA" modified="2018-02-28" version="1">MSRSLAQSCFRQLSRSPLKQGSLPVFLAPAFSSQRTQCFSTTSPTQSRVGGAALSIPPEVTLKFIDLPQTQVRGMAKEKPKVAIEVKGPLGEMTLDLPPFLEVAHDEATRKASLTVQDPEIAHQRAMWGTIRAHLQNYILGVSEGHICILSLVGVGYRATVESSATTVEPEYPGQQFVSLKVGYSHPIELGVPQGVKASTPQPTRILLEGVNKNVVTKFAAEIKEWRRPEPYKGKGIFINGETIKLKAKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRB8</accession>
    <name>A0A2I2GRB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retrograde regulation protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_344774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710696.1">
        <property type="nucleotide sequence ID" value="XM_024843481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRB8"/>
    <dbReference type="GeneID" id="36551181"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344774"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000007">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="3">
        <location>
            <begin position="341"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="558" mass="61180" checksum="2D8773060913C490" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRG3</accession>
    <name>A0A2I2GRG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_422019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710778.1">
        <property type="nucleotide sequence ID" value="XM_024847405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRG3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRG3"/>
    <dbReference type="GeneID" id="36555104"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422019"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="30156" checksum="A9832BFF73AAEAD8" modified="2018-02-28" version="1">MYGGFIVSPNDSGALFGVLFWHKDGFSTACGHGTIALGYWAVAHRMLPVPDNEEVDVIIDVPSGRVKSRITMQGGDPIHAEFINVLSYQIAKDLSAALPSRGAVVTADLVFAGAVYATIDADQLGVEVDPCNYAQFIQLGREVKHSLGQRAHYGTHDLYCVIFYREEDVGKDEAGIVRQRNVTIFADGQIDRSPCGSGTCARLAVLLSRGRVGAGKNKLVHQSIIGTSFEADVVSEEPSPVEGFKACIPRVRGRANIVGQMRFWIDPSEAMFPGFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRH0</accession>
    <name>A0A2I2GRH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_375238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710770.1">
        <property type="nucleotide sequence ID" value="XM_024845311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRH0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRH0"/>
    <dbReference type="GeneID" id="36553011"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_375238"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="67"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="199" mass="21965" checksum="6BD5F8BC5659C28C" modified="2018-02-28" version="1">MRFQTLYSSLRLFAIPLRSRVIPRAATAPPPRPRATILKAAPTIPFLSSFFSSSPRDNMSYPDQRSDDAWRAVLSPEQFRILREKGTERAGTGEYDTHYPTEGVYGCAGCNAPLYKASHKFKSGCGWPAYFDSLPGAVTRHTDSSFGMERTEIVCSNCGGHLGHVFKGEGFPTPTDERHCVNSVSLRFQEDGGEPKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRK5</accession>
    <name>A0A2I2GRK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS drug efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_470899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710786.1">
        <property type="nucleotide sequence ID" value="XM_024852795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRK5"/>
    <dbReference type="GeneID" id="36560493"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470899"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="29"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="551" mass="58840" checksum="410C2600C51B7202" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRN4</accession>
    <name>A0A2I2GRN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tryptophan synthase</fullName>
            <ecNumber evidence="5">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_443295</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710837.1">
        <property type="nucleotide sequence ID" value="XM_024850531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRN4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRN4"/>
    <dbReference type="GeneID" id="36558230"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443295"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="346"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="471"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB55535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="639" mass="68198" checksum="D53BDEA72A11E6F8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRP3</accession>
    <name>A0A2I2GRP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_443293</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710835.1">
        <property type="nucleotide sequence ID" value="XM_024850530.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GRP3"/>
    <dbReference type="GeneID" id="36558229"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443293"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1110"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1139"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1181"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1219"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1254"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1372"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="78"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="773"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB55533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1401" mass="155477" checksum="39896E4359F67E0B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRU4</accession>
    <name>A0A2I2GRU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_422135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710903.1">
        <property type="nucleotide sequence ID" value="XM_024847419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRU4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRU4"/>
    <dbReference type="GeneID" id="36555118"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422135"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="489" mass="53572" checksum="9AA13A20FD1874D6" modified="2018-02-28" version="1">MGRKLGLFRAIYLVSASCMGSFAFAFDTGVISGVLTLESFQNDFGYGSKQQTSVNSNAVSILQAGAFFGCFFTMPVASRLGRRSGLILSSLIFTVGTILQVINAHTLGTFYAGRVIAGVGIGAATVLIPMYAAEMSPKEIRGRLGACFQLFFALGVMIAYWVTYAVSKNQPSATKQWQIALGLQLLPSTLLLAGMCTVKESARWLAAKGKTEKAWESLKWVRGGEETEELRQEFDEIIAGIEEEARVRENLTLRELFLPVNRYRLFIAVTIQLCAQLTGNTSLAYYANQIFSAVGAGSSAKLVTGFFGVVKVVGVSIFQLFVMDRIGRRVPFMAGAFAMGSFMLIIACVLATHPTSASGEQSGATKAGIAMIIMTYAEAFSFNMSWGPLPWLYVGEIFSSRTREIGVAVGAASQWLFNFMMSQVTPHAIDNIGWRMFLMFAIFNYAVIVYSWFFLKETSRHSLEEMQEVFGGEPQPDKLPDESGVLDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRY0</accession>
    <name>A0A2I2GRY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710949.1">
        <property type="nucleotide sequence ID" value="XM_024848414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRY0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRY0"/>
    <dbReference type="GeneID" id="36556113"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433152"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="246" mass="26949" checksum="D253B16504B5C2A6" modified="2018-02-28" version="1">MAVSQTLPPTGFGLLGMTWRPKVTPDEQAFAAMKAAIAGGATIWSSSSMYGMDPEPPTAGLWLLRRYFEKYPEDAPKIQLFIRACFDPVSFKPQTTRAGVRASYEECQTILGEFKKINVFGPARIDKEVPVEETVGALKELVEEDKIDAVGLSEVGAKSLHRAAAVCQISFVEVEFSLWSTEMLTNGVAEACKQHGMTILTYAPLGYGFLTGQVTKLEDIPKGDVRHMFGRFQPEVCRSSIALSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR12</accession>
    <name>A0A2I2FR12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_514668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698375.1">
        <property type="nucleotide sequence ID" value="XM_024855237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR12"/>
    <dbReference type="GeneID" id="36562943"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514668"/>
    <dbReference type="OrthoDB" id="4320931at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="233" mass="24848" checksum="BE748B7EA297B35A" modified="2018-02-28" version="1" fragment="single">MSPLGSPQRSAEVSTQTSWPPRPVGQTSWPGGPKRLSTLSARVGGKFGWPTLYGKSDRRTGHPILKPSPPATFGHLNVCAHDVCPSEAGGTTWKGGQLDSRKHPSRGTFRGVPDGLPSTSSLLDRLPLHGSQRLGPSGLARVVGAVYRWRPLHCGQRRPKPGCPAPGADGVSAVRRRVRGAGPLTRGPYAAAWQRPQGRPAGVLRADRLLEGYTVWAIGWSHVCRRYAGGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRV0</accession>
    <name>A0A2I2FRV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arginase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_394903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698662.1">
        <property type="nucleotide sequence ID" value="XM_024846078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRV0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRV0"/>
    <dbReference type="GeneID" id="36553777"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394903"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000001">
        <property type="entry name" value="Agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014181144" evidence="9">
        <location>
            <begin position="16"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="373" mass="39829" checksum="EC6315EB6640C8E4" modified="2018-02-28" version="1">MFKSALLALSTLSSAREIVFPPVAAVHPAGQFPLGHHDPVDITSGSQFSGLTTFAHLPYVNCFVDEEANTQRYDIAFLGAPFDTGVTGRPGARYGPGGIRLGSRRLGGWNIYTGENVFESWAKLVDCGDAPLTWLDNTVALKQLDQAHKVVSSRPANSTEKGRVPRIITLGGDHTTTLSALRSTHEKWGPVSVIHFDSHIDTWDPEVLGGGVSHYAGVNHGTFLHLAHEEGLIRNTSIHVGIRAPVNRGKADLRNDVRCGFDMIKARDLDRLGIDGVVEQIKSRVGDSRVYISVDIDVLDPAYAPATGTAEPGGFTTRELLSILDALRGLPVIGGDVVEVAPIYDTVAETTTLGAAEVANSLLALMVATPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS42</accession>
    <name>A0A2I2FS42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_451436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698728.1">
        <property type="nucleotide sequence ID" value="XM_024851186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS42"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS42"/>
    <dbReference type="GeneID" id="36558885"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451436"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="42"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="41284" checksum="87582B7639A7EF2B" modified="2018-02-28" version="1">MAPSLTDTAPVVPIVEEKLSSKTLQREPIKFKSALDAFKSFDVTPIIGREFPTANLKEILRAPNSDDLLRDLAITVSRRGVVFFRKQDELDNDLQKELVQRLGELSGKPSTSGLHVHPVINSGREHGVKDDEISVISSAERQKLYRDRNETKRQSARREWHSDITFEPIPSDYTILRLTQLPETGGDTLWASGYEIYDRISPPYQKFLESLTATYAQPGFNRIAKENDFEIFTGPRGAPENVGHVLQAIHPVIRTNPVTGWKSVFAVGTHVEKINDLAEEESRHLLDWFVTLIVENHDLQARLKWQNPNDLAIWDNRSVYHAATFDYVNLGPRTGHRVVGLGERPYFDPLSTGRREGLEREAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSP9</accession>
    <name>A0A2I2FSP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_417884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698949.1">
        <property type="nucleotide sequence ID" value="XM_024847183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSP9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSP9"/>
    <dbReference type="GeneID" id="36554882"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_417884"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="151"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="469" mass="52635" checksum="58BB019657CBAB93" modified="2018-02-28" version="1">MLASLELLDRHCQTSSISPLAEICPTKAFYPLPPKEDVMALLHDYLQTVNVLCPLFQPSVLMSIFDCHDLDAMFQFPSRWACINVVLAMGHILRIKDRSVAQPEHQKSWQFIKNALGALTEICLGPPDLWAIQALIGMVFFLLGTPNAQPCSFLISTAINLAHQIGLERTDEEQSISDPEEREQRRRIFWIAYCIDREISLRFGCVPAQRDEDMVVNLPTDSPTDGVGVVPTRDGQDIFNIFRSCCELAMIKGHVYKRLYSAAATDRPLAQTVAAVASLDEELQRWKKTIPSEYQPDSPFPILLPQSPECGLLLISHYSYFNCVISMHRLIVTRELFKEMDLSQNIGPSTSPTLPSNESVFMSASLCARAARDSIHLIKYMPEDNISIIGILLHYAMVASKTLSFGILRNPNEASRVYDMKLISRVETFLSSLILSTPNEGVDRLVQYCAQYRSVAEAAIKQAAKDPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSS0</accession>
    <name>A0A2I2FSS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_450879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698985.1">
        <property type="nucleotide sequence ID" value="XM_024851151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSS0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSS0"/>
    <dbReference type="GeneID" id="36558850"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450879"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="387" mass="42917" checksum="C740E374E132AADB" modified="2018-02-28" version="1">MCRFLVYKGSHEIRLSKLVTEPSHSILTQSYDSRLRLDNRRPVNGDGFGVGFYTDPKLGPEPCIFTSTLPAWNCENLERLASKTCSDLIFAHVRATTEGALSDNNCHPFQHQTLMWMHNGGIGGWHYIKRMLADSLADRWYLGVKGGTDSEWAFALFLDLLEKEGVDPSCDPGPEGFGQALLRKVMVKTIAKINEFIRDIPKRHNVSGVETRSLLNFAVTDGHTVVCTRYISSKTDEPASLYFSSGTKWKEGKDQGHFKMERHDKGADIVLVASEPITFERHNWVSVPANSIVTIHKQTVLLHPILDEFYSEDLNHDRSSCYAVSKGLVSTAPGTTVHPKNVDGSTRAAEPELPAPAASAQNWGPDDLSAQMAQHRIACANQCAVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT87</accession>
    <name>A0A2I2FT87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_322044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699123.1">
        <property type="nucleotide sequence ID" value="XM_024843318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT87"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT87"/>
    <dbReference type="GeneID" id="36551018"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_322044"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="32576" checksum="D165A1F8F7A942A7" modified="2018-02-28" version="1" fragment="single">PTPQSTMPPEDRLGLRLANQIELKSVLGNDSLANSIYTGIDIQTKSVYAVKAFSKISSDRNGQRELRLHHIASEHRNVLQLVRIIDAPDCMYSVMEFSPEGDLFDNITAKSMYSGDDSLIKKAFIQILNAVRFCHAHKIYHFNIQPESILVANQGKTLKLSSFEFATTDYFSTAFNYKRNFYVSPESLRTDQGPDACYFSAPHDVWSLGVVLINLICGRNPWKLASVEDATYKAYLEGPGFLRTILPLSNDIMRFLNRVFESDASKRIGILELRDWVYRCPCFTVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTA5</accession>
    <name>A0A2I2FTA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_418227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699154.1">
        <property type="nucleotide sequence ID" value="XM_024847206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTA5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTA5"/>
    <dbReference type="GeneID" id="36554905"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418227"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="357"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="477" mass="53295" checksum="3694406124F56F1E" modified="2018-02-28" version="1">MSSMPLEPPAYLSSLQNNIRARPIPWEGAVRAGNITDDHLKKIKAVDKVRKEQRRQTVEGDLPGYVGLLAGSSDGKSVLDLASRRTDIVQYILVLAADLINDVPSLSSALVAHPSPYKPFLPLLRHSTNTEDPIPLLTSTFLTNLVSISLVSTSKSTPRDEEALPQLFTYLSSLTQNQDSGLQDIGVQKLSALLRTSRSRELFWKQRKETVDPLVEILRAAAGAKDTGSSTLAGSSRIEPGLAGGVGLQLLYRVLLVLWQLSFEGSLIGDDLQADHEIIQLYSHLLRLSPKEKTTRLLLATLKNLLSSNRTTLLPVAVFVRLSALLSNLSGRHLTDPDLLEDLKYLSDMLEEYTKTQTTFDQYAAELQSGHLRWSPPHRNPTFWKDNARRILDDTNAALPKKLAEIISKSWDNDKQVLAIACNDVGHLVKELPERRNQLERLGLKARVMELMADKDETVRWESLRAVGEWLRYTFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTA8</accession>
    <name>A0A2I2FTA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_418241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699158.1">
        <property type="nucleotide sequence ID" value="XM_024847207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTA8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTA8"/>
    <dbReference type="GeneID" id="36554906"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418241"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="367" mass="38596" checksum="D2D1C0FC0B81B701" modified="2018-02-28" version="1">MPPIRLSKSLPSLYPWVTSPFIVSAPMRIMSGPALAVSVSRAGGLGFIGPGAKTQDALTNLQEASSLLKAPSTTLSSLPSTPLPIGIGFQLWSDDLATAAAAIQQYQPCAAWLFAPHHTADIQTWTLRIREVAPNTQIWVQVGTIAEVHEILTSAAQPDVLVIQGAEAGGHGRATDGMGLMTLLPEVADIVAMASSPGRGKIPVFAAGGIADGRGASAALCLGAEGVVMGTRFLAATEARISAGYQNEIVRAGDGAASTTRTLLYNHLRGTFGWPAAYSPRGITNLSFHEHQAGKPFEELKRLHDEALGMGDAGWGPQGRLATYAGAGIGLIREVKEAGRIVEEVRREVWGKVNVKVEEEGGREARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTR9</accession>
    <name>A0A2I2FTR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_441446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699306.1">
        <property type="nucleotide sequence ID" value="XM_024850312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTR9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTR9"/>
    <dbReference type="GeneID" id="36558011"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441446"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="200" mass="21907" checksum="1DF0924ADC31D163" modified="2018-02-28" version="1">MTSRLVLVIGDLFIPDRAPDLPAKFRKLLTPGKIGQILCLGNLTDRHTFEFLRQVAPDLQLVKGDFDVDSPNLPLSKVVTHGSLRIGFTHGHTIIPPGDADALLIAARQMDVDILLWGGTHRFEAFEMEGRFFVNPGSATGALSTGYWPEGEDPTPSFCLMDIQGDVLVLYVYQLKTDANGAETVAVEKVSFRKNNVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTS1</accession>
    <name>A0A2I2FTS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_418597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699337.1">
        <property type="nucleotide sequence ID" value="XM_024847229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTS1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTS1"/>
    <dbReference type="GeneID" id="36554928"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418597"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="50631" checksum="CBFABA93B86101F7" modified="2018-02-28" version="1">MSSSDEDVVRRPGRSSGAGQPASPSGSERSNPAARLESPAGSDAGNMNGDDDADLFGSDGSDGGFGNDDDQPKRTLDDEELDSGDDEDRRDRTGERMDYEDGDQGEYQETVNIMDLSLGRAPEPVTSNGEIYTMPIPNFLSVETEEFNPETYVAPPYSTAATSLCWRHDPDNDALLQSNARIIRWEDGSMTLQLASAPKEQYRISTKPLAPVNKSGDYDTKLDSHVYLGAAAETSSVFRLTSHLTHGLTVYPTTMEADDAVQRLQESLAAATRGSKQTADGSAPVIEVTEDPELAKRQAELAEREKLKAARRRQQLADRELDRGRRVGVSRTGGAGLTVGGLEDDDGLLTTRPRAKKPRKPNRRGEIYTDDEEDYDRKGRTREDEYDEDDGFLVGSDEEPEVADDDEDEDLLEDEDMDAEGEEEEPSAAKPKQRRASPEEAAGTPPARKKNRFIVDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTV9</accession>
    <name>A0A2I2FTV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_394189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699319.1">
        <property type="nucleotide sequence ID" value="XM_024846051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTV9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTV9"/>
    <dbReference type="GeneID" id="36553750"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394189"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000067">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="264" mass="29348" checksum="9FFADB9A16786928" modified="2018-02-28" version="1">MTPPHRLPVGRSAVQRPLQKNPSPASPRLPSSGHVSSQLAPPWPFNPQDTALIRAGYRPAFNPTTTATPEQSHTVENDNQDPPNQGKKKKKNPPKMAEPRARAARHKGQMNFSSELRLLLLAYGDPSPHPSFPSEPLPETVRVLDEIVTDFILEMCHGAAQYASYSRRQKIKVDDFRFALRRDPNKLGRVQELLRMERELKEARKAFDQNDDQVGNLKDAGKKGLEELGEGADGKKSKGKGKRGARRDSDATEDTAPKKRKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU46</accession>
    <name>A0A2I2FU46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_392240</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699470.1">
        <property type="nucleotide sequence ID" value="XM_024845966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU46"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU46"/>
    <dbReference type="GeneID" id="36553665"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392240"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014176752" description="chitinase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="176"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="111"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB44168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="732" mass="79760" checksum="73BEBC5162B42688" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUJ3</accession>
    <name>A0A2I2FUJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_440579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699569.1">
        <property type="nucleotide sequence ID" value="XM_024850111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUJ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUJ3"/>
    <dbReference type="GeneID" id="36557810"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440579"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="8">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="248" mass="27974" checksum="E2F7383B52380C29" modified="2018-02-28" version="1">MPRSKRAKIVHESKTTKKSHKEQTRRLYANIREAVEKYEHLFVFDVNNMRNTYLKDVRTEFADSRLFFGKTKVMAVALGQNPESEAATNLYKLAPYLTGAVGLLFTSRDPQSVIEYFENFRPLDFARAGTVSTRSFSLPNGLVYSRGGDLPADQDEPISHTIEPELRKLGIPTRLVKGKVMLELTEGQDSFPICREGEVLDSRQTTLLKMFGVVSSEFHVALKAHWTRDSGEVEILEKGQGGMEVDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVT6</accession>
    <name>A0A2I2FVT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PhoG like DNA-binding family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_429460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transcription factor that acts as a positive regulator of nonrepressible acid phosphatase activity. Is a major regulator of responses to nitrogen and carbon starvation and is essential for the expression of genes involved in vegetative incompatibility (like pin-c, het-6, and tol). Vegetative incompatibility is a non-self-recognition system ubiquitous in filamentous fungi which results in programmed cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699998.1">
        <property type="nucleotide sequence ID" value="XM_024847892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVT6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVT6"/>
    <dbReference type="GeneID" id="36555591"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429460"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000002">
        <property type="entry name" value="PhoG like DNA-binding family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NDT80" evidence="11">
        <location>
            <begin position="80"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="9">
        <location>
            <begin position="80"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB44696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="584" mass="63107" checksum="9F74C48C45F5D4C7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVX4</accession>
    <name>A0A2I2FVX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_479304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700059.1">
        <property type="nucleotide sequence ID" value="XM_024853658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVX4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVX4"/>
    <dbReference type="GeneID" id="36561356"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479304"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026093">
        <property type="entry name" value="MGARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22910">
        <property type="entry name" value="PROTEIN MGARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22910:SF6">
        <property type="entry name" value="PROTEIN MGARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="621" mass="67797" checksum="F4796BDD6B072D39" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW59</accession>
    <name>A0A2I2FW59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_415670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700174.1">
        <property type="nucleotide sequence ID" value="XM_024847072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW59"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW59"/>
    <dbReference type="GeneID" id="36554771"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415670"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014181169" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="135" mass="14381" checksum="7FB5972D82E4D1B7" modified="2018-02-28" version="1">MMYTKILTLTTLLLTGALAAPQPVPQPLPRACDYTCGSNCYSSSAVNSAKNAGYDLYSDGETVGSNNYPHRYNNYEGFDFPVSGTYQEWPILSSGSIYSGGSPGADRVVFNTQNQLAGVITHTGASGNNFVECDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWJ8</accession>
    <name>A0A2I2FWJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminoadipic semialdehyde synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_440178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700313.1">
        <property type="nucleotide sequence ID" value="XM_024850017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWJ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWJ8"/>
    <dbReference type="GeneID" id="36557716"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440178"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014196351" evidence="4">
        <location>
            <begin position="23"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="125"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="464" mass="50255" checksum="C6803E12AE3EEDA4" modified="2018-02-28" version="1">MASGKKALLLGAGFVCPPAVQALSDAGVHVTVASRTLSAAEAITSGRSNTSAISLDIANSEALDPAVADADIVISLLPYTLHAAVVKSAITHTKPVVTTSYISPALWDLNEEAKAVGITVLNEIGLDPGIDHLYAVKTIDEVHRAGGKITSFTSYCGALPAPDNADNPLGYKFSWSPRGGLLALLNPGQWYENGKIAEVKGEDLMASAKPNDDFPQFELVGYPNRDAVGFREFYNIPEADTVFRGTLRYKGFPEIIRTLVTIGYFSQEQLAPLGADEKEPLTWSQLTARLLGLSPETSEAELETAVLEKAHFLSKEESERVVSGLRWIGLFSDEEVELHGSPLDTLCAVLEKKMAYGPGERDMIALQHKFDVLRPDGVRETRTSTLIEYGEPIAPGSRSAMAKLVGLPCAVGVLAVLRGDIKEKGMVAPWTSAEIATLLRDELKQKHKIQLKERFTIELEEQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWN2</accession>
    <name>A0A2I2FWN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_513115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700340.1">
        <property type="nucleotide sequence ID" value="XM_024855063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWN2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWN2"/>
    <dbReference type="GeneID" id="36562769"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513115"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="267" mass="30826" checksum="13758D94E131F87C" modified="2018-02-28" version="1">MSVPDEDPERKEMRKSLRSLERHVTGLKPDHQIAPSEIDRIQLMPLSLDEGSKDRPVFFTPLDESFLETPDDEYDQKYGMEYDTYDSIPEDCRDPKTCAQAINIYWSTYLSRYSLGKQPVGGEIVWSPVRIGYTVYKDLYRYGFPEFGFTDAEQVKTGPYAHMKATIYNNLNGDDDHLLQGEMLPILRLMIGHLRRARFIDHMVAPLMVFSFLGPQHARVIEAYVEDHTVVVRRTKLYDLRSKDAAAFKLFARWFFGKPGAPTGQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXF9</accession>
    <name>A0A2I2FXF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_440406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 8"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700568.1">
        <property type="nucleotide sequence ID" value="XM_024850071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXF9"/>
    <dbReference type="GeneID" id="36557770"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440406"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000294">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="267"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB45266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="419" mass="46047" checksum="18D44264AD54A178" modified="2018-02-28" version="1">MTTMNNLAPFQRKHKVTVVGSGNWGTAIAKIVAENAASNPSIFEKDVQMWVFEEKVEISKDSRHYNPSSPLCQGPQNLTEVINTTHENIKYLPGIALPTNLHANPSLVDAVQDSTILVFNLPHQFIIKTCEQIKGKILPYARGISCIKGVDVQEEGISLFSETIGKILGIYCGALSGANIASEVAQEKWSESSIAYDPPHLDSKAPTPDRSPSSSTTDVVHFEHRDVSGQFSRVKLRALPTEFVPIDHDVLKSLFHRPYFHIRVVSDVAGVSLGGALKNVVALAAGWVEGMGWGDNAKAAVMRVGLLEMVRFGEKFFGATFEPRTFTEESAGVADLITSCSGGRNFRCAKLSVERKQPIEKIEETVLNGQKLQGTLTAFEVNSFLKKQGQEEEFPLLTVVYRILQGTMSVEDIPSFIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXM0</accession>
    <name>A0A2I2FXM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_439146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700681.1">
        <property type="nucleotide sequence ID" value="XM_024849771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXM0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXM0"/>
    <dbReference type="GeneID" id="36557470"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439146"/>
    <dbReference type="OrthoDB" id="4174291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="125" mass="13706" checksum="BE267CEB4A6A974D" modified="2018-02-28" version="1">MGDNNQATTFGNDPAANASDAAAFGKGKGKATEDPTAMEMSMDEEEESESEGEDMINDDDDDDDQDTLEPISSDNIISGGRRTRGKNIDFQEAAEKLKNDDIDDDDDDEDFAPNEDNDDDDKMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXV2</accession>
    <name>A0A2I2FXV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fms interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_439217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700759.1">
        <property type="nucleotide sequence ID" value="XM_024849792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXV2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXV2"/>
    <dbReference type="GeneID" id="36557491"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439217"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="209" mass="24070" checksum="9427C4674B126F82" modified="2018-02-28" version="1">MAVRDLVAEPSLLPVLSTNAETRDQCQRLLAALDPTADSDPQEAALAASKEQKRLFALLARLRGQNREAILRVRETKQSTAEGRQEIDRLHLQLQNLYYEQRHLTGEIAACESYDHKYLALPLIPVEEFLALFPEHNDSDAHELMVARINHEHAEREKLEQARQELLKRKQALIAENNKRKDDLASLDQDLERFIDAAKPIQKLFEKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY16</accession>
    <name>A0A2I2FY16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_512197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700823.1">
        <property type="nucleotide sequence ID" value="XM_024854967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY16"/>
    <dbReference type="STRING" id="1392250.A0A2I2FY16"/>
    <dbReference type="GeneID" id="36562673"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512197"/>
    <dbReference type="OrthoDB" id="5377952at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="2">
        <location>
            <begin position="772"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109600" checksum="9D4CEBCB9F3BD17E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY53</accession>
    <name>A0A2I2FY53_9EURO</name>
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        <recommendedName>
            <fullName evidence="16">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="16">HMG-CoA reductase</shortName>
            <ecNumber evidence="16">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_364578</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). In this module, the cytosolic acetyl-CoA acetyltransferase catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="16"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700866.1">
        <property type="nucleotide sequence ID" value="XM_024844648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY53"/>
    <dbReference type="STRING" id="1392250.A0A2I2FY53"/>
    <dbReference type="GeneID" id="36552348"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364578"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
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    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
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    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0521">NADP</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="241"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB45564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1130" mass="121243" checksum="FFCC40BD94F5527F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ94</accession>
    <name>A0A2I2FZ94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_414683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701254.1">
        <property type="nucleotide sequence ID" value="XM_024847025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ94"/>
    <dbReference type="GeneID" id="36554724"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414683"/>
    <dbReference type="OrthoDB" id="3546893at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="857" mass="93195" checksum="8BDD95C4D9FE0262" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZE8</accession>
    <name>A0A2I2FZE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_414640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701238.1">
        <property type="nucleotide sequence ID" value="XM_024847023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZE8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZE8"/>
    <dbReference type="GeneID" id="36554722"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414640"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="324" mass="35529" checksum="32D063272AA1499A" modified="2018-02-28" version="1">MSSSLEQLKAAGTVVVCDSGDFATIGKYKPQDATTNPSLILAASKKPEYAALIDEAVAYGKKQTGSLDAQVDATLDRLLVEFGKKILEIVPGKVSTEVDARFSFDTQASIDKALRIIQLYKEIGIPKERILIKIASTWEGIKAAEVLQRDHGINTNLTLMFSSVQAIAAAEAGAFLISPFVGRILDWYKAAHKRDFAPQEDPGVKSVESIFNYYKKHGYKTIVMGASFRNVGEITELAGCDYLTISPNLLEDLHNSTEAVPKKLDSANAVNQDIPKRSYINDEALFRFEFNEEAMATEKLREGISKFAADAVTLKDILKAKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZM0</accession>
    <name>A0A2I2FZM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_390553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701384.1">
        <property type="nucleotide sequence ID" value="XM_024845908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZM0"/>
    <dbReference type="GeneID" id="36553607"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_390553"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="32917" checksum="F204D42B0EF15BE9" modified="2018-02-28" version="1" fragment="single">MAKRSPFVSLGQMEQSLGYELTSSPEFRHDVQRFYSDLTPVLESIYDQTRKELEEHLSAKRRPDSAAHEITPVAGAAFLKLPRELRDRIYTYAIPRQEWKVVNADYLGGVNLAGGLGDPTGFYFPLRIGLSLINLNRQIRTEALPLVHRRTMFRLGDMDDFIKLAITVGEVGRENIESLEFAWQSRSDIEATVENEPDIEDPYGKPPTLHAVRCVQLLRQLKRLRFLRLIFPDDLVSNKTDDEIKLNPGIQGLFSIRGIQTVEVRNEHSVSLEKVDVLRDLRQRMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZS6</accession>
    <name>A0A2I2FZS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_512709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701435.1">
        <property type="nucleotide sequence ID" value="XM_024855012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZS6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZS6"/>
    <dbReference type="GeneID" id="36562718"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512709"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="235" mass="25531" checksum="B8DF984F841CF5F1" modified="2018-02-28" version="1">MASKYPPVQGGGSLILAWQVKQKNILVIGGGEVAAGRILHALNADAKVTVVCPASGLNDEVAFRVSEGQVSHIDRNFEPTDLDEADMVLCAIDDPEASTQVWKLCKEKRIPANIADVPPECDFYFGSVHRDGPLQVMVSTNGNGPKLASIVRKKIAETLPDNMGAAIDNVGKLRKKLREVAPLAEEGPKRMKWMSGVCESWSLDDLVQMNDQDMDGLLAHYKSGKIPPLEEIRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZW5</accession>
    <name>A0A2I2FZW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_260828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701418.1">
        <property type="nucleotide sequence ID" value="XM_024843073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZW5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZW5"/>
    <dbReference type="GeneID" id="36550772"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_260828"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="26"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="341" mass="38061" checksum="B7186E9A6D7FEF9F" modified="2018-02-28" version="1">MASAQDPLDGISGVLENGKDGIKATLFLFIAIACYNVVELVVLVLSTFRRWGGLYFWSLLLSGCLGVVPYSLGFLLKFFTGATSILSVTMLSVGWWTMVTGQSFVLYSRLHLVIRDERILRRVLYMIIANIFLLHIPTTILTYGSNVKDPSRRFVQGYNIMEKLQMTGFTIQEVIISALYVWETVRMLRLGSERSKQKIMHQLVGINVLMFVMDLVLLGLEYANYYAIQITLKGAIYSIKLKLEFAVLGKLVDVVHSHQRPPSLDNAVQLNSLDAGNAAMPAVGSSRLSRNMTFCTVADALTCGPSRQENKASPRRMANGKIVTMTEVSTWVERRRGNSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0A6</accession>
    <name>A0A2I2G0A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_427657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701624.1">
        <property type="nucleotide sequence ID" value="XM_024847787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0A6"/>
    <dbReference type="GeneID" id="36555486"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427657"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="128" mass="14309" checksum="D31751C97780B29C" modified="2018-02-28" version="1">MQWQTIEVNGGLEHITQQSFARLKRNVSQATNTADEEILDVPDMPDMPDVPELAGRSEISRAPKLPDFPKDVEDKPLIPYHLAPAQQSSNYSTEPPSNREPALVLSAVTGQDLPAWQEQTSLEEKLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0H4</accession>
    <name>A0A2I2G0H4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_427707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701687.1">
        <property type="nucleotide sequence ID" value="XM_024847791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0H4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0H4"/>
    <dbReference type="GeneID" id="36555490"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427707"/>
    <dbReference type="OrthoDB" id="4524525at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="394" mass="46437" checksum="67A673DC0872B2CC" modified="2018-02-28" version="1">MPMSRIMSKRFYAPLPQPFDPCLYCVACGAEFPMHDPRDIYDEREDWTRLRKKRKNRVAYVSDQELEQTDFKRHPELWSFFYRTILDDPQSGSLRLSGISDHRSWGWYPLPAPLDIHKARIGGIPNPDGRHNVDFHMVNMLNADWNREKGQLIGYPIHVPCWLLLDRVIGHEIIRDNLRPFIQAVEGFWKDNSKLWEVLLTHSQEEDECYEKGQHWLKDPPKIKKKPNQRQRSFPIKQVTPKPWHEPGSPYRIPAIQDLIDKACQVKDGHRHPIIHNHMVSMMPIEIAVMIIDMIYRGQKHSQARINDTWNALYAFQWTLPDTYWQSRCNPELVFEIDDLAQSGKAVDWPYLCLGLEELLLDEDWYCNSGLNNRGRTMSIMSGIRKRFLVLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0L3</accession>
    <name>A0A2I2G0L3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_498239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701721.1">
        <property type="nucleotide sequence ID" value="XM_024854128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0L3"/>
    <dbReference type="GeneID" id="36561833"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_498239"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="446" mass="47730" checksum="02CD025ABA5070D8" modified="2018-02-28" version="1">MSSPRTSKENHDLQPWANNESGSSVTVSGSPNEQPVVDEKEIPPPPDGGVEAWLVVVGAWCTSFCSFGWVNSIGIFQSYYESNMLKNYSSSTISWIPSLQVFFMFAMGPIVGKLYDAFGARYLIIAGTFFHVFGLMMASISTEYYQILLSQGVCSAIGASAIFQPALNSVSVWFNKKRGIAFATLSTGSSVGGVIFPIMLERLVQQVGFPWSMRISAFMILFLLAIAIVTVKARLPRSKSSAAGKTTLLHPFKEPAFVLTLFGYMLLTYGVFIPINYVIVEAELNGMSARLAAYLLPMLNAASLFGRLGAGFVSDRLGRYNIFIAMCLVAGVLVLALWIPAASNAPTIVFAIIFGFASGAYVSLSPALVAQISPLTEIGYRTGLLFLFASVGGLTTSPIAGAILANAGGKDFTNVKVFSGVFLLGGTVFVIAARIMKTGVKLGAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G124</accession>
    <name>A0A2I2G124_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2-heptaprenyl-1,4-naphthoquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_477462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701884.1">
        <property type="nucleotide sequence ID" value="XM_024853466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G124"/>
    <dbReference type="STRING" id="1392250.A0A2I2G124"/>
    <dbReference type="GeneID" id="36561164"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477462"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="263"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="483" mass="53504" checksum="F7F65080986AB45B" modified="2018-02-28" version="1">MGSNIETLFDPAGILNNERTSQLVRALVEGVPPESKVLSVGCTTSLPILSLLSSASHHIYGIDGSQKTLDFAQTQVSGQFEQAPAVEYLPQSSFDVILGIFSLHEMNRAQVRSLVFKMGDWLKPGGFILLATSPIDYLDTESRHNIVDDCIRDYPLNLFGNSVHSTLFSRNEWISMFEKAGVSLDNEAYLTVSATADRPSQHHSFMSFRKSVKHSILGPYPLPEEYRGPIPLSEAAWKPFVDRLVRDEFDFVLQVLESNQQVLDVGSGYGKLPIEVAARTGKAYSIEPNADRNSIQTANARDRGVEIAQGSAENIPYPDAHFDAVVAMWVMHYVQDLEKSLREIVRVTDRSAPNSRIVIVQGAPDNEIIDLMNTVCAPLSASNPLPNHQGYLLHKAAEVFAACEFGNITFHRVDAYCEFTEQDLSDRCEQAAGVIAGLWCLDDSNFNGMKQALIPRLRFHFLDRPHAIGDQVAVLVARPSEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1J4</accession>
    <name>A0A2I2G1J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline phytoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_387618</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702040.1">
        <property type="nucleotide sequence ID" value="XM_024845811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1J4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1J4"/>
    <dbReference type="GeneID" id="36553510"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_387618"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="327" mass="38385" checksum="FB2061C74772693A" modified="2018-02-28" version="1">MPDWFAPPFIPYPPAKAGYWSPVTSTLNWCEEDYYATIYSAEIINTLTNLLFMWLGVKGFLSCRRHGHDSIFKVAYAGYLLVGTGSFLFHSTLKYPMQLVDELSMIYTTCLMCYASFSYSRPNPIRVILAISLAALAVFITLYYHYLQDPVFHQNAYALLTTVVVLRSMYTMEVTLRPKWRHTTEEDRLARQRQGLPVPSKEHQHYENVRDTKILKTMWFMVVYGLSLFLGGFLIWNLDNHFCSEIRGWRRVVGLPWGVFLEGHGWWHVMTGIGAYLYIIWGIWLRHCLNERQEEFYLWWPRFWNFPEIIRAGPRAKTENGAVKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1S0</accession>
    <name>A0A2I2G1S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_223798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702122.1">
        <property type="nucleotide sequence ID" value="XM_024842875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1S0"/>
    <dbReference type="GeneID" id="36550574"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_223798"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="179" mass="20255" checksum="1B29B979B3C5337F" modified="2018-02-28" version="1">MCGVNNHPRKIDLYRTPLPPRDRTIEGVGPRIPQTSWMTRNPSIHSHDDLSSFWSLSQSSKRPTDHRRDTFATQCKQDKKLSAKLVPRDRSRPPTTMTKPPISTRGPRARRPHPVEWTAYEGNNTPHRLDQSPLQRTAGSTGLAGLSCFSLPFFVPETISRVISRAIQRPPALPPFSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2G2</accession>
    <name>A0A2I2G2G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IDI-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702363.1">
        <property type="nucleotide sequence ID" value="XM_024849681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2G2"/>
    <dbReference type="GeneID" id="36557380"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438773"/>
    <dbReference type="OrthoDB" id="3660930at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190777" description="IDI-2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="17988" checksum="621B7B14DDA8495A" modified="2018-02-28" version="1">MKLPITILSMLALSSALTLTPKGDPVVECGDLGVMTVDPADLPAGVAPSDVRKCLDHPLGRNRHVKGASLAPLDAVDASFYNGTGDTDTSPVEARVDGLDGALEKRACYKDAPYGCSGGYCWKACGDMNKGEWCWTAAKDGLGAWMKCSTWQHCGTTSYACGKGGCQACGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2H6</accession>
    <name>A0A2I2G2H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_457465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702384.1">
        <property type="nucleotide sequence ID" value="XM_024851720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2H6"/>
    <dbReference type="GeneID" id="36559419"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457465"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1002"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1058"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB47082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1133" mass="125110" checksum="963B597C4C337C49" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G315</accession>
    <name>A0A2I2G315_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_438965</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702576.1">
        <property type="nucleotide sequence ID" value="XM_024849733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G315"/>
    <dbReference type="STRING" id="1392250.A0A2I2G315"/>
    <dbReference type="GeneID" id="36557432"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438965"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="14">
        <location>
            <begin position="239"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="335" mass="36563" checksum="5D98791B05455809" modified="2018-02-28" version="1">MASAPPAPRKTFTIGTRKSKLALSQTDLVQNALQAIWPDHTFNIHSQETAGDQNTTIALRDFTTKNLWTQELEELLIAGKVDFIVHSLKDVPTLLPPTCTLGPTLKREDSRDVLVMKKGLPNMSLADMPAGSVVGTSSIRRTAQLARRYPHLKIMDVRGNIGTRLAKLDAEDGPFTCIILAAAGLLRLDLHDRISQYLDSKNGGMLYAVGQGALGIEIRKDDQVMHDMLKQICDMDATYACWAERSLLRTLEGGCSAPLGVETEWIQLPDGSKKLRMRSIVVSVDGKEDAEVEIDGTVDSAESAEEFGVLVAKELVAKGAGKILDDIQRNKQTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3J3</accession>
    <name>A0A2I2G3J3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_413391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702750.1">
        <property type="nucleotide sequence ID" value="XM_024846976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3J3"/>
    <dbReference type="GeneID" id="36554675"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413391"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07739">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF14">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="293" mass="32745" checksum="4611C6625F324F65" modified="2018-02-28" version="1">MTLRSAVYIAPPTPFRNPAKPNDNKPAGLWSPISCTLVYSATHAVLIDTPITIKQTRSLISWIERIAPGRQISYVYITHGHGDHFFGLPLLKAKYPDARVLATPGTIKHMEQQIEDRNYQSQWESRFPGEIAQPFISADPIPSGNEFKLQGQWCFQAIEVGHSDTYDSTVLWVPDLRLAVCGDVVYGQVHQMLGEASTAAKREEWIRAVEKIEALDPLYVVPGHCQEGEIMGRWHLGNTKEYIEDFARVVESKPKSAREIVAAMTKLYPDRFNTGALVIGAMGAMQAAKQSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3K1</accession>
    <name>A0A2I2G3K1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_512028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702729.1">
        <property type="nucleotide sequence ID" value="XM_024854952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3K1"/>
    <dbReference type="GeneID" id="36562658"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512028"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="311" mass="34831" checksum="84351C6B4F193EE2" modified="2018-02-28" version="1">MAIAVAGGTGGVGKTIVSKLSGKVIILTRSKPEPPSDTNSPEDRKKVQVEYNDISSLSKTLEDHDVHTVISAISIYDGETSQSQLNLIQAADKSNVTTRFIPSEYSFIQTHDLLPIDPSIQHFIDAVQLLQKTNLQYTRVIPGFFMDYWGMNPEKVIQTNLQPSAFGTDIANCEAAIPGDGNDRICMTYSEDMATFVARLLDVKDWPEFSVVVGDEYTYNEIIQLGQELQGKHFKVVYDSHERVKEGKVTVPKMPPGCPYSEDEVYEMTVLVSRLTIAGVFDLPKIGRLNDRFPDISTKKLRDFMRDAWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3R6</accession>
    <name>A0A2I2G3R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">CFEM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_360908</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702826.1">
        <property type="nucleotide sequence ID" value="XM_024844441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3R6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3R6"/>
    <dbReference type="GeneID" id="36552141"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360908"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014122692" evidence="17">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="93"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB47524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="199" mass="19246" checksum="B98492E5151AC998" modified="2018-02-28" version="1">MKFSAVFLALLTAGIASAQFDNIPQCSVQCLVDALTKDGCSQLTDFACHCQKPGLVQTVTPCVQKACTGPEQATVSSVVVEQCAKAGHPISVPPAGGAGSGSATATATAAPTSGSAQTTSGVMTLPTVSSSGHAGSSSRPGSSSPGWGSSSRASSGAGSPTSHAPSATTSTLLATGAASQNRDNMVGVAVAAAAAVCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3Y8</accession>
    <name>A0A2I2G3Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_476276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702896.1">
        <property type="nucleotide sequence ID" value="XM_024853332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3Y8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3Y8"/>
    <dbReference type="GeneID" id="36561030"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476276"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="540" mass="61529" checksum="9746523628A9CA16" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G422</accession>
    <name>A0A2I2G422_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="1">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FDC1</name>
        <name evidence="5" type="ORF">P170DRAFT_447560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G422"/>
    <dbReference type="STRING" id="1392250.A0A2I2G422"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447560"/>
    <dbReference type="OrthoDB" id="4878259at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="99"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="264"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="439" mass="48840" checksum="42DED68B0FA47F72" modified="2018-02-28" version="1">MGDNKTPVNDLPHMNFRSYIGSLRNDNDLVEIDTEVDPYLEVGAIIRKVCETDGKAPLFKNPKGKRGHLFQILGAPNSLRSDSTQRYGRLARHLGLLPTCDASWTNWSIARGMNTGPDQLGVLIAKPQHIWQIQQQWKAEGKDMPWALAMGVPPAATMAAGMPLPDGCSEGEYVGAMTGHAIDVVKCETNELLVPANSEIVFEGTISSDAEDCVLEGPFGEMHGYVYPGERHKSPSVRIDTITFRDNAILPVSCPGRLTDETQTMVGPLAAAEIRQRCQDHGYPVVEAMTPFESQVTWVALQIDTVRLRQMKTTAAKLCKSFGELIFHHKCGLTIHRVVLVGDDIDVYNFQDVMWAFCTRCCPIKDEYLFDDCQAFLLIPYMAHGNWNPLKGGKVISNALLASEYMDGPDWETGDFEHGYPDNVKDRVIARWDEMGLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G435</accession>
    <name>A0A2I2G435_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Synaptic vesicle transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_447575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702946.1">
        <property type="nucleotide sequence ID" value="XM_024850890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G435"/>
    <dbReference type="STRING" id="1392250.A0A2I2G435"/>
    <dbReference type="GeneID" id="36558589"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447575"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB47644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="481" mass="52669" checksum="E8E8B0F22DB87112" modified="2018-02-28" version="1">MGAGKPMPPVVPDLVAYVVELEGSNDPMHPHNWAMRARVLYTALLTFCALTTSYTSAVFATTTQSVMKEFDFGHEVASLGTSLFVLGFAAGPIIWAPASELTGRRWPLTIGTLGFSIFTIADATCKDTQTLMLGRFFAGLFAASPITLVPACLSDLFNATHRGAAIALYTLAMFTGPYTAPFIGGYTVTSYLGWRWALYTPAIVGFFNTLMLVCFARESYAPMVLVEKARLLRRQTGNWAIHATHERLEITIHDLITKTIARPFHLLFTEPLAFLVTIYMSFIYGLAYGLLQAYPIVFQQIHGMQGGNSGLPFIGLIIGQMIATGVIMLLQRSYVAKLKANNYVPVPEWRLPPCIAGGIAFSAGLFWFGWTGYTSSIHWMAPTAASVFIGFGIISIFMQCFNYLLDCYLQFAAAAFAANTIMRSLVGAAFPLFSTQLFNSLGVQWAGTLLGCIAALLVPIPFAFLYWGPTLRQRSRMAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4D2</accession>
    <name>A0A2I2G4D2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pre-rRNA processing protein Tsr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_385631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703042.1">
        <property type="nucleotide sequence ID" value="XM_024845736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4D2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4D2"/>
    <dbReference type="GeneID" id="36553435"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385631"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="85"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB47740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="798" mass="90052" checksum="81ABA5C499AEA9D7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4R9</accession>
    <name>A0A2I2G4R9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_437591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703177.1">
        <property type="nucleotide sequence ID" value="XM_024849404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4R9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4R9"/>
    <dbReference type="GeneID" id="36557103"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437591"/>
    <dbReference type="OrthoDB" id="4225201at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014164275" evidence="4">
        <location>
            <begin position="20"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="547" mass="60002" checksum="635F13A834E8D9CA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4V8</accession>
    <name>A0A2I2G4V8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703218.1">
        <property type="nucleotide sequence ID" value="XM_024853359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4V8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4V8"/>
    <dbReference type="GeneID" id="36561057"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476569"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="40385" checksum="4A8B3919B192F627" modified="2018-02-28" version="1">MPLFVESPIPPQLDLTGPPSQIFAPTTSSASSALYRSISIPSRKRCRYYESGARAWTDSSTDLISATPLSSPDGYHPSLSHLGSDDLTSEADCYRPNRYKDYPRPFDGSVESLAEVSEVRRKRSRRDPHTSPPVAPAANEKIAFAGDYGEQDDYNTGFLSQPAPVRWTRAVLGVVGKVWGFCWSGAFRGFYAGGGQGYAMTVEQGPTEKQDAMLPSAPVQSERDATPIPGEYPDDELRQNWVMVSSRDQPADYVDDAASSSRKRRAQPHRRAGSGLMRRRQSGNRTLMSAPSSSGLPTAHFSSPAKPRETPVSVETQRYMAQRRRIEREEDASLRRLNRQLQAMIKEGKQALGTRVEVDDYMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4W7</accession>
    <name>A0A2I2G4W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Synaptic vesicle transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_410307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703220.1">
        <property type="nucleotide sequence ID" value="XM_024846841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4W7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4W7"/>
    <dbReference type="GeneID" id="36554540"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410307"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="77"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="515" mass="56956" checksum="EAF379B3060BDFF6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5Y4</accession>
    <name>A0A2I2G5Y4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Velvet complex subunit laeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_359846</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703593.1">
        <property type="nucleotide sequence ID" value="XM_024844382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5Y4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5Y4"/>
    <dbReference type="GeneID" id="36552082"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359846"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB48291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="370" mass="42746" checksum="BFE0CE0D714E4495" modified="2018-02-28" version="1">MFGNGQVEQRPLTMAAPSQNHFYSQPADASRSRNNSDAMDIYVITDRDTAREEPSGYSSWNRNGSPSMNSTYSKSSERQSFHEENGRTYHAYRRGVYQLPCDEEEQDRLDIFHKLFTVARVSDGLIYAPHPRDGRFLDLGCGTGIWSIDVANKYPDAFVVGVDLAPIQPPNKPPNCEFYAPFDFESRWALGEESWDLIHLQMGCGSVLGWPNLYRRIFSHLRAGAWFEQVEIDFEPRCDDRPLEGLALRQWYQLLKQATQDTMRPIAHNSRDTIRDLQEAGFTEIDHQMVGLPLNPWHQDEHERKVARWYNLAISESIESLSLAPFSRVFGWDLDKIQRISRDVKSEAFNKEIHAYNILHIYQARKPANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6A2</accession>
    <name>A0A2I2G6A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_448111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703709.1">
        <property type="nucleotide sequence ID" value="XM_024850944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6A2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6A2"/>
    <dbReference type="GeneID" id="36558643"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448111"/>
    <dbReference type="OrthoDB" id="5209368at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="614" mass="70657" checksum="A8A0EB751C988086" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6G4</accession>
    <name>A0A2I2G6G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_360554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703764.1">
        <property type="nucleotide sequence ID" value="XM_024844420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6G4"/>
    <dbReference type="GeneID" id="36552120"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360554"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29981" checksum="93C19A745F9FE61F" modified="2018-02-28" version="1">MPSEPKNEATRQIRRLVIDATSAAIAAGLVTPAVSIMDRHRRIVVENSCAPVALKTGLRKHFISAIRSPRRFATSRPCLLVFALYMGTFGVANASQTLLEARSPDVDPAIAQGTTVLSTLSVNVPLGIYKDTVFSKLFGCAVVARGGSSVLSAIPRTPWLTYASFLLRDGVTIYTSFSLPHTVAAAMPDVPASYQHAASIASQMVVPAIGQILNTPIHLIGLEIYNRQGNTSPASTLALLRRDLASATITRMCRIIPAFGLGILTNNEMRSWLNKPVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G706</accession>
    <name>A0A2I2G706_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703969.1">
        <property type="nucleotide sequence ID" value="XM_024847661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G706"/>
    <dbReference type="GeneID" id="36555360"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425703"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="178" mass="20191" checksum="1F6C0128765B8D58" modified="2018-02-28" version="1">MCLSEENPTVSLACLNRLYSVARAPIRPPRGTECLGRNAAVKVRYRLQLSYRVRRRVRGMCMSSASGRVEATRISRVGYRSLSWMLRTVDVLILLTLAVSGLGLRPTLSASTPTRTGKRTVRLRRQGFPSLAWKYQPEWTDHPRTQTRLVQKVEKNSTPPASFDVFPEWTGDRNEAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G762</accession>
    <name>A0A2I2G762_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_407372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704000.1">
        <property type="nucleotide sequence ID" value="XM_024846678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G762"/>
    <dbReference type="STRING" id="1392250.A0A2I2G762"/>
    <dbReference type="GeneID" id="36554377"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407372"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="645" mass="72487" checksum="5C6EC3F6359E21C8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7T9</accession>
    <name>A0A2I2G7T9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_407771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704246.1">
        <property type="nucleotide sequence ID" value="XM_024846698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7T9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7T9"/>
    <dbReference type="GeneID" id="36554397"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407771"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="588" mass="61958" checksum="68BDF07431FAD14D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G869</accession>
    <name>A0A2I2G869_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_174660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704381.1">
        <property type="nucleotide sequence ID" value="XM_024842627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G869"/>
    <dbReference type="STRING" id="1392250.A0A2I2G869"/>
    <dbReference type="GeneID" id="36550325"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_174660"/>
    <dbReference type="OrthoDB" id="4396256at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="211" mass="24966" checksum="D5DDAAECC38A58AA" modified="2018-02-28" version="1">MMNSIRRHARFELLPTELLYEIITRLSSRDVKRLSSVSERLRKVCLPYLFRNVSFEFSRSGFISLQRLLLSNLRWYVVSLTYVVPELLQSEIMDFRFFRNNILPPKNYLDELKQSSDKDCPAKPPPPYMVIYDTFRGICKEQHDILKRREDIEVLSAALGQQLPKLTGFCVYFRRTNAKEHWVGSYLDTTMTMQEKTLEHHFHAIIKGLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8S2</accession>
    <name>A0A2I2G8S2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1687-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_408385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704573.1">
        <property type="nucleotide sequence ID" value="XM_024846729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8S2"/>
    <dbReference type="GeneID" id="36554428"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408385"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15727" checksum="FE3B9B29481B6179" modified="2018-02-28" version="1">MVFRFAKTIDPITLFHKPSLPSSARTLNILKQASAAAESGSLPSSTRGEFQLEITTAPPTTDQLRNILDYVTANPAGAGANKKQYAIEEVVRGARDAEEAVKRFKEDPEGSFVRPVTVDWTNGQAVVGDNESEILRMVHQLDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9N6</accession>
    <name>A0A2I2G9N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane associated DnaJ chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_475895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704901.1">
        <property type="nucleotide sequence ID" value="XM_024853299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9N6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9N6"/>
    <dbReference type="GeneID" id="36560997"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475895"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="76"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="360" mass="40528" checksum="27B49582F34F7EA1" modified="2018-02-28" version="1">MSSILSFVGWAVLPNYVTSLVQSVYYGLTIRAGDPRPQPPSPRYARHRRRIFILVVTGYLLYTLYESFHRVQVAGDFYKALGVSPLADDRTIKSRFRRLAAQHHPDKITQGEGLPADNYFVYLKLAQDTLLDPAKRFAYDRFGPDVLGWGDRHKTMQDFLMTGLQRSLLPYVGGFVTIIFLNFTWWASWGRYWRFFTFGALLTLELTLITHPGALFIPSNYIPPALRDLLGISAANPSFYLLPFQILTLAQRASVTLHIFISQVTPPEISQKPSGTGDRLSPQTMQKLAQLLQLSRTTDGEATRLLQLGFAPFRGDREGVATLRKGMKEGLVLSSVRASPGVQTAVGEVVERKMREKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9V1</accession>
    <name>A0A2I2G9V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_510169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704947.1">
        <property type="nucleotide sequence ID" value="XM_024854749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9V1"/>
    <dbReference type="GeneID" id="36562455"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510169"/>
    <dbReference type="OrthoDB" id="4451047at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014154591" evidence="1">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="110" mass="12096" checksum="10578D729DBF54EA" modified="2018-02-28" version="1">MYFNALALLFASAALAQPKPRQNEPADIQVSFALAGQNPTFGAVENECTFFPYGNEPISDILITPLTLQDPTCVFYTGYSCEGQEWTLKQGPHHFSRPFLVGSFVCKGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA88</accession>
    <name>A0A2I2GA88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705091.1">
        <property type="nucleotide sequence ID" value="XM_024853316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA88"/>
    <dbReference type="GeneID" id="36561014"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476073"/>
    <dbReference type="OrthoDB" id="4435608at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="214" mass="24751" checksum="31741770905AFD8F" modified="2018-02-28" version="1">MPRKWVSVYTGPEPFRYLFDEYCEALKRLLNGHRVLITNHDTSGLHLHLCFSVFITSHQNLDAVDTAVAMIEYLINPRTRNPLDTGSGLPHLLFNDSRYPMRQLTPIEWTDRHVDADRAQNRDRFGEGADDFAFRQARRRATRDLVTYHRDEYGCTSAVLNDNEGEITITNHDPRDGFEYSGSSWRSKGPGPSSVEDHKDRFPLLGWDLPTEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAB3</accession>
    <name>A0A2I2GAB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-polyprenyl-6-methoxyphenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_357558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705110.1">
        <property type="nucleotide sequence ID" value="XM_024844225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAB3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAB3"/>
    <dbReference type="GeneID" id="36551925"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357558"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF13">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="417"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="629" mass="69837" checksum="935B6BE11854582E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAU5</accession>
    <name>A0A2I2GAU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal-dependent decarboxylase conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_491566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705292.1">
        <property type="nucleotide sequence ID" value="XM_024854022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAU5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAU5"/>
    <dbReference type="GeneID" id="36561726"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_491566"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="990" mass="110712" checksum="849AF39F5B7B27E7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB23</accession>
    <name>A0A2I2GB23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_445473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705384.1">
        <property type="nucleotide sequence ID" value="XM_024850712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB23"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB23"/>
    <dbReference type="GeneID" id="36558411"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445473"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="200" mass="23110" checksum="5CBC41719A06F163" modified="2018-02-28" version="1">MSLPVYHYLDIGRLGRGEVLNLFLKDAGIEVKQVRYPMDATWPQQSETLKAQGISRTGKVPSLEYKGQILTQHIPTLRYLARDIGGYDGETNWERYVVDAVADIYIDWRSQWVANLGQKNPDYKDYVPGYYSLVAQYYSDYEGPYLLGDRVTYVDFAIYQSIDNDARTGTLPAELPDVLVRFKETFEQRPRIAEYIKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB68</accession>
    <name>A0A2I2GB68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_445486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705407.1">
        <property type="nucleotide sequence ID" value="XM_024850715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB68"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB68"/>
    <dbReference type="GeneID" id="36558414"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445486"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="290" mass="32548" checksum="19EDBF790185B66D" modified="2018-02-28" version="1">MASPIPQLVRAAIPAYACPAGTKMHILNLGTLSVDEGWLLMGANGGSASNPNPTNKRRDLMLIAALIDHPEMGLLLFECGSAQDVHAQWGDEAVDVFPRTTYEERHHLPVAIRSAGYDIKDVRAVIMGHLHLDHAGGLEHFRNTGVPIYVHEEEFKHACWAAATKSEGGLYLADYLSLDNTLNWQTFNDTQLDLCTGITLYHCPGHTPGLCIMQVNLLHDGTFIWTTDQYHVRENFESNWAHGWLARDYRSWVDSGKLIRRLQRVFGARLVFGHDFEVAEGLIREKGFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBY1</accession>
    <name>A0A2I2GBY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_381007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705677.1">
        <property type="nucleotide sequence ID" value="XM_024845550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBY1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBY1"/>
    <dbReference type="GeneID" id="36553249"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381007"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="543" mass="61352" checksum="409A22F5087A5C93" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCH7</accession>
    <name>A0A2I2GCH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_381458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705888.1">
        <property type="nucleotide sequence ID" value="XM_024845572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCH7"/>
    <dbReference type="GeneID" id="36553271"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381458"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="528" mass="59604" checksum="C94989911941F7BF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCK6</accession>
    <name>A0A2I2GCK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_405904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705920.1">
        <property type="nucleotide sequence ID" value="XM_024846601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCK6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCK6"/>
    <dbReference type="GeneID" id="36554300"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405904"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="585" mass="63139" checksum="FF85687E81A4F540" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDJ8</accession>
    <name>A0A2I2GDJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_326013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706276.1">
        <property type="nucleotide sequence ID" value="XM_024843343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDJ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDJ8"/>
    <dbReference type="GeneID" id="36551043"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_326013"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="259" mass="28016" checksum="E9D02A1AEC4374FF" modified="2018-02-28" version="1" fragment="single">MQPSDDQPPTDRPGTPPRPPYSPVTPVLSHLAPVPNNNNGNGFPASSIVPPRSPSPTSRVAPFGLPPPPPPPSFVPEPAPVPISESENPDAIALRSALSILQMQKQQSLRDMRTLERLKKAAAADPEGFARELAAGNLSAKEAGFVNFTHEDGDEDEGEDGDGDGEGRQREGSRAGLGTIPTPQNVVRMPPVNWAKYQIVGEPLDRMHEDQQRRPFAGEPRREDPMQRAPEHVLASPYRPLVDRLETPGKVKGTGKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDN4</accession>
    <name>A0A2I2GDN4_9EURO</name>
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        <submittedName>
            <fullName evidence="7">Bromodomain associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_355309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024844083.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1392250.A0A2I2GDN4"/>
    <dbReference type="GeneID" id="36551783"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355309"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTP"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="215" mass="23335" checksum="994EBBD1D4C3ADAD" modified="2018-02-28" version="1">MSGANLHNALLRPPIIQILRAAGFHATRPSVVDTIADLTARYMMILASSATAHAANAHPSDPMPVLEDIYQALQDAGALRPQLREWEEDWQNEEDIRGLEGFLAWFTGPANREIRRIAGFVPSEGDVVDADSLEKEDYLTALKKKHSKTGEESRYAGTVLGKSAEEHPVVIEGGVPSIQEWGTQVRSRAPYLAESDSSAVSSAPSNLSDAEGMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDP3</accession>
    <name>A0A2I2GDP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_474484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="36560847"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474484"/>
    <dbReference type="OrthoDB" id="4506637at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="514" mass="57504" checksum="44D241E37CBB12F0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEH5</accession>
    <name>A0A2I2GEH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_425517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706572.1">
        <property type="nucleotide sequence ID" value="XM_024847640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEH5"/>
    <dbReference type="GeneID" id="36555339"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425517"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014131037" evidence="2">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="247" mass="25843" checksum="C78FB7F3BFC001FF" modified="2018-02-28" version="1">MKASILASIVLGCSVGLAAPLPNNNDIFTAGSISERNQVPRTNIKDLTGGAAGGAKKNASPDRRTIQVVKREQGAADAANARLDKEFFSGKKREQGAADAANARLDKEFFSGKKREQGAADAANARLDKEFFSGKKREQGVADAASAASIPDKRSASATKREGEAVDVADARKNEDSGSAMKSEEGVVASRENDAARSATKRQGPLEFHDISNPAAAAGQKRAHKVPAKQANGQLQSLDIVGFGSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEK7</accession>
    <name>A0A2I2GEK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF821 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_407076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706594.1">
        <property type="nucleotide sequence ID" value="XM_024846665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEK7"/>
    <dbReference type="GeneID" id="36554364"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407076"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="147"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="422" mass="48265" checksum="4EC803BC6F72ABB6" modified="2018-02-28" version="1">MFNRLHFRGLYVLYLLACALVGLIVWGLWFGVNSDRDNVPTLLNQLIPAGHCACETSLEFKCDTCLHCSADAPTSSPEENRKYNPLYDAHNLSLSDAQCQGFFPGLFEDINRAQGLWESRGGITTEDLDDIEFVDSMARAAIVDGQLYFVFSVEDRLDDVAGPDYPIWILARKPDEESVWLMPDFGFWSWNNGHTDRPIGPYNAVVDRVVRREKDEFPWDEKEAKLVWRGKLSFAAKMRRGLLEAARGKPWGDVKELDWGRKDNFMTMEDHCRYRYIAHVEGRSYSASLKYRQACMSVVIAHKLQFIQHHHYLLVSSGPDQNFVEVERDFTDLSDKMQHLLDDPALSERIANNSVATFRDRYLTPAAETCYWRKLLDGWTSASPKISQDVQSSTIADDGLRFESFLLLDSKAMMDFSGSYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GER2</accession>
    <name>A0A2I2GER2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_164375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706643.1">
        <property type="nucleotide sequence ID" value="XM_024842586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GER2"/>
    <dbReference type="GeneID" id="36550283"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_164375"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="112" mass="12872" checksum="D375D997B051A4A8" modified="2018-02-28" version="1">MNWRSSTLNKSHLSGHMASCMHPPCRILPHLHLSNHSDTQPRTQIKVQHSLVQGSFSWNMIAVEIHASLHAPVTDTHPHKMKTEPRTWDLSPTRRSRVQVSELTLHYKLSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF20</accession>
    <name>A0A2I2GF20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_422482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706774.1">
        <property type="nucleotide sequence ID" value="XM_024847434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF20"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF20"/>
    <dbReference type="GeneID" id="36555133"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422482"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="6">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="253" mass="27722" checksum="6D984DC2397E7E3F" modified="2018-02-28" version="1">MKYSAAVAITAALAQSASAHYIFSKLVLNGVASEDWQYIRQTTRTENYMPTKFSNTFDNLTPKDNDFRCNLGSFSNAAKTEVADVAAGDKIAMKLFYDGSIAHPGPGQVYMSKAPSGNVKEYEGDGDWFKIWEKTLCNESGDLTTDAWCTYGSSELEFQIPEDTPAGEYLVRAEHVGLHGAHENEAEFFYSCAQVKVSGSGNGSPSETYEIPGLYNDNMKLFNGANLWMNSADELKAYIQDTPIGDAVWGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFC7</accession>
    <name>A0A2I2GFC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phospholipase/carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_453224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706839.1">
        <property type="nucleotide sequence ID" value="XM_024851348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFC7"/>
    <dbReference type="GeneID" id="36559047"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453224"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF1">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="225" mass="24802" checksum="A4A65760FF46358C" modified="2018-02-28" version="1">MSRPRIACFHGGGSNSTIFSIQSAQLSELLSEFEFVFFDGPFERGPGPGVLPAFRNDGPFRSWFTTDPSGLEVSDGSGFGDGEEDGIERIYRLMDAKGPGGTWVGVMGFSQGTRPAGGVLLDVQRGERKTVPGRDIRFGVLCMGGGMPMESDGKSSTSALVTLPTLHVHGLKDMFLPLGQHQFTTYYDPSKAQLYEIDYHHAMPWVRAEVEHFGDLIRKMYRQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFQ5</accession>
    <name>A0A2I2GFQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_83921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707017.1">
        <property type="nucleotide sequence ID" value="XM_024855413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFQ5"/>
    <dbReference type="GeneID" id="36563120"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_83921"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="100" mass="11666" checksum="C994939EEC58472E" modified="2018-02-28" version="1">MDMSRSLVFPPTFPFVFTTLVLFLFMATLSCRSIHLLFLSFYLFSFYLFSPLVRQFCLFPRSISGRDRYQATGTSPRLSGRNVVRLGFHAFTSDCFLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH65</accession>
    <name>A0A2I2GH65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_444256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707518.1">
        <property type="nucleotide sequence ID" value="XM_024850620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH65"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH65"/>
    <dbReference type="GeneID" id="36558319"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444256"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="470" mass="52285" checksum="31914A52A24D5416" modified="2018-02-28" version="1">MGKTLGLVRAVYMVSICCDSFRYGEAQKSTINSNSNSLLQAGAFFSCFFVWPFTARYGRRWSIALASLIFCVGAIIQVIPTHSIAAFYVARVISGIGVGMATVMVPMFSAEMAPKEIRGQLGSMFQFFFTLGVMTSYWIDYAVEKHVPPSDRQWQIPVGLQLVPGGILGIGMLFLKESVRWLAKKGRHEEAMQSLVWIRGGEETEEVRAEMAEILGGIRAEEQATEGVSWKELRQPANRYRMLITVTIQIGVQLTGNTSLAYYAPQIFKAVGAGQDSLLISGFFGVVKVVACFIFVVFLVERIGRKWSLIMGAFVMGALMLIVAILSKTFPPDPNATSIASPGVASIAMVYLEAMTYNMSWGPVPWLYMSEIFPSRIREMGIAVGTATQWLFNFVFSQATPHAVDNMGWRTFLMFCIFNWALVVYAWLFIKETTGKSLEEMEEVFQSKAVLFRKDAGPHEETIESVQGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHA2</accession>
    <name>A0A2I2GHA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Manganese lipoxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_350708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707548.1">
        <property type="nucleotide sequence ID" value="XM_024843818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHA2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHA2"/>
    <dbReference type="GeneID" id="36551518"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350708"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014186587" description="Manganese lipoxygenase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="607" mass="68782" checksum="9FACBEFDB56A3553" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI26</accession>
    <name>A0A2I2GI26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cenp-O kinetochore centromere component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_402791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707840.1">
        <property type="nucleotide sequence ID" value="XM_024846445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI26"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI26"/>
    <dbReference type="GeneID" id="36554144"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402791"/>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37319" checksum="52CE832D67DFC962" modified="2018-02-28" version="1">MDPTEDPQNMEEELDSDITSIRAEIRTLQRRKRLLASSILSSSEFQKRVKSLSAPSLTSLAKKLSPLLTDAENHADVNHHRIAFSATSFPFKDPDPNARDQNLLGLRIDLCQRDGRFVKPYYVLLKRVESGKENGEKRLKVHRHTIPAFIPMESLERVYLPGASSGSATEGGERGDDVAAMKARQKATKPRKQDLQGLVRELRRQLVAWQLRVDAIGLLRETLGVVRRGVDDYQDDDGVWERNFLNHKEETRLEANDLGIVSLGPTALEAVYVRVEWASGQVGRFKISNSGIVERAVVIGDNGRDKALEVALTGGNARVETVLDRLKKHAEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIB4</accession>
    <name>A0A2I2GIB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_107816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707923.1">
        <property type="nucleotide sequence ID" value="XM_024842304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIB4"/>
    <dbReference type="GeneID" id="36549999"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_107816"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014118454" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="23684" checksum="9463DD52AD9A0522" modified="2018-02-28" version="1">MFVKRTFSVFLALAGASSSLSESEPDSDSESLESFLAAALGASFLSESESDSESEDSESEDSAFLAGFFCSFLGAGFSSSDSESEESEDSEEDSSFFSAFLPFLGSSAFFCCFLGAGFSSSLSLLEEASSMSSSLSDDSDSEEDSAFLAGFFCSFFTSFLAGFFFSSSLSLSLSLELELDFISSSLSDSDSELLLGVGSFFLLLDFFSLVARSRAICLLLALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIN6</accession>
    <name>A0A2I2GIN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_110761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708009.1">
        <property type="nucleotide sequence ID" value="XM_024842312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIN6"/>
    <dbReference type="GeneID" id="36550007"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_110761"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="130" mass="14958" checksum="8F545034FCED7A98" modified="2018-02-28" version="1">MDLTVLRISDLIGHQVTQTGVFFFFFFFFEISPLSRFIPCPFVVPFSFLLSRINPIMLTRARLPPLRANDFRSKRIGLRFLHQSEQTSRDIGRLSFNCFQGPSTESGSQMCPCVSIYSHTSSTFWPPNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIX4</accession>
    <name>A0A2I2GIX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_349454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708120.1">
        <property type="nucleotide sequence ID" value="XM_024843736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIX4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIX4"/>
    <dbReference type="GeneID" id="36551436"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349454"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="454" mass="49151" checksum="2EA23D1E997EA168" modified="2018-02-28" version="1">MRSQLSTIIAAPVSPPILIGFHSNNALYRTLIVSIWELGEIVAPLIWGPLSELYGRRWVLSIANALFIAFHAGTALSTNIQMLIAFRFLSGAATASLPIGPGIVRDLFAEERRGRAMSVMSLTSTLGAVAGPIVGSYLAEREGWRWAFWLPTVVAGALALLLLAVYRETYQVTILKRKAQQRRRETGNLDLRSKYETGETDANSTTGAVTKLFHAFIRPLRLLVRSPMLILITVYISVVYGYTYLMMTTIAPVFQEIYGFSTGASGLCFLGLCLGLALGAFICSFVLDRYIRMAKAKASAQAQAQTGSEGPSSAPSPITPEHRLPPVLVSCVFMSTGFFLFGWTVHAHVHFIVPIIGTAVIGLGLVATTITLQTYIVDVFGIYAVSATSAMLVPRNASAAFLPLAGPPLFQRLGYHWGGTLLGLVVLAFAVMPVGFMRWGARLRGKDRTDGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ07</accession>
    <name>A0A2I2GJ07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_114404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708163.1">
        <property type="nucleotide sequence ID" value="XM_024842327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ07"/>
    <dbReference type="GeneID" id="36550022"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_114404"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="130" mass="14143" checksum="2CF593E4D26A40B5" modified="2018-02-28" version="1">MVFSFSPSSPSLFPSRSVDGLQAIRPEPRPSNHPTGGIGPSSGDRLVICSPWRRLRSPATNETRLFSPDPACSCRIIGTWFQIAVSIGALSQLVSPCLGLNAWFDSPFLFFFFPGPIEISIFIPCSRTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ70</accession>
    <name>A0A2I2GJ70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_434646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708228.1">
        <property type="nucleotide sequence ID" value="XM_024848757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ70"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ70"/>
    <dbReference type="GeneID" id="36556456"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434646"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="294" mass="32088" checksum="E09C5E624A9904F7" modified="2018-02-28" version="1">MLTDVSFSQNLYELLGNDPELDPNREPAPPTRALDKPVPRVGKRDAPKEAPAQARTTESAPRRGGRPTGNEAAFRDRNAGRNNNREKPVDDGSQPQRREGRGGRGGRSDRQSRTGQTDSRKQVNQGWGGQSGDKEWADEKAAEAIAHNDETEPQTPGEEAKEADKSKSYNDYLAEKAAQGDLSAKPVRAANEGSKADKKWNEAKELKRGEEEENYFKGKEDKNKREKQRKEKNFLDVDLRYVEAPRGGGAPRGRGGRGGRGGRGGRGNGPRAADRAPGAAPVPVDEKNFPSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJT8</accession>
    <name>A0A2I2GJT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_349457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708448.1">
        <property type="nucleotide sequence ID" value="XM_024843737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJT8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJT8"/>
    <dbReference type="GeneID" id="36551437"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349457"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59274" checksum="8B8DC5D9F6C02B78" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJW9</accession>
    <name>A0A2I2GJW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_490164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708476.1">
        <property type="nucleotide sequence ID" value="XM_024853990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJW9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJW9"/>
    <dbReference type="GeneID" id="36561691"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_490164"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="200"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="344" mass="37478" checksum="831119DD287D6385" modified="2018-02-28" version="1">MSKANVLLVGCGGIGTIAALNLQIGQKATVTAVLRSNYDHVKNHGFHIRSVDHGIVEGFRPDTIIKSIPDVAKEGIQPYKYIICTTKNVPDNPPTLLDLIKPAVTPGYSVIVLIQNGLNIEKPIVAAFPTNVVLSGVSFCGSHQVQLGKIVHEDNDDVAIGPFDNPALDPALQEQAAREFVEIYGAGGKCQPEYNPNVGWARWRKLLYNACLNSICAVTDLDTGRIQLADAVVDGLVRPAMEEIRAGGKACGHDLPADLVDKMITMDPITMYNPPSMQVDLRKGRYCEYENIVGEPMREGIKHGVPMPTLTVLYNVLRAIQWRTKERNGLISIPDPVDHTATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKE1</accession>
    <name>A0A2I2GKE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_473214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708647.1">
        <property type="nucleotide sequence ID" value="XM_024853021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKE1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKE1"/>
    <dbReference type="GeneID" id="36560719"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473214"/>
    <dbReference type="OrthoDB" id="187836at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="ASPARTATE-GLUTAMATE RACEMASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198">
        <property type="entry name" value="GLUTAMATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="Aspartate/glutamate racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="229" mass="25321" checksum="6001E478A7B31BFA" modified="2018-02-28" version="1">MKTIGIIGGLAWPSTVAYYEGINRLVADKLGTLHSAKLILIQTDFDQLLQWLLADKWDKIGDALCSLARRLEGAGADFILVACNTMHRVMARIQEQIRVPICHIVDAVSEKIKPMGIRKVGLLGSVVTMRDGYFSDRLAEDRIESLIPGPEDQEFILQALKTELSVDIYTPETRAVFRDIIARLVTRGAEVIILGCTEFGKLIKPEDSPVVIIDTVPVHIELAAKMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKS4</accession>
    <name>A0A2I2GKS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_508091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708783.1">
        <property type="nucleotide sequence ID" value="XM_024854533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKS4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKS4"/>
    <dbReference type="GeneID" id="36562239"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508091"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="598"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1062" mass="121901" checksum="D6F63A56A9236F07" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKZ8</accession>
    <name>A0A2I2GKZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_435129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708821.1">
        <property type="nucleotide sequence ID" value="XM_024848865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKZ8"/>
    <dbReference type="GeneID" id="36556564"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435129"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="271" mass="30721" checksum="913C9C9487B7C55A" modified="2018-02-28" version="1">MSTESTGFQIISDLHLEINQQYSSFEIPACAKFLILAGDVGRLADYDAYRDFIQQLTARFELVFLVLGNHEFYNGTFAEGLRKAEALERDPSLNGRLVVLHRRQFDIPGTRVSVLGCTLWSDVPDQSKDIVRAKVKDFQRIEGWTVDDHNANHKSDHSWLVKEIESIKRANEGRSQNETRFVLVVTHHAPLTRGTSKPQYEGSPWSCAFGTDVLPHLSAGVDTWMFGHTHYSTGFQEEGVRVVSNQRGYVLPWHNSTDASSGFDVRRVLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLB7</accession>
    <name>A0A2I2GLB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_396239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708975.1">
        <property type="nucleotide sequence ID" value="XM_024846107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLB7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLB7"/>
    <dbReference type="GeneID" id="36553806"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396239"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF14">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="429" mass="48076" checksum="151388FED16124BB" modified="2018-02-28" version="1">MEPDRPTAPVSPKSPVRRRPQACQRCRKRKQKCDRLLPACTACVEAAIPCSARSVPLEPSTEEGSGLSHAAIPNYVESLKRKSDELDGQIRRLRSRLGGDTSVETTHSPTQHIDPTRPTDVSDQTPMSDHTERSVQVAMGEIGFLSRNAMAEPRDETRAFPQEVAMKSMVHAALAVPGTASPFYSRATHHRLSFKSIVDRADMLTQDTATPYVDIFLEHLGAVFLHIDLKETKEQFFAFFEKPAEGSSDDASATSVSTYRYFHAYMIVAIGMMLSPDHGIHLLASSFHDMAREKLPLIMETCDNLTTLHCMLLLVHYSMLSPIGGSTWHLLGLAMNKSILLRLHKEPSPDSGMSAKEISRRRNLFWSIYTIDRILGCVMDRPFSIQDDDISLKVSYSCEIVSISAEKGQVSEHQRQSRSCIWRLRSYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLC8</accession>
    <name>A0A2I2GLC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_431488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708961.1">
        <property type="nucleotide sequence ID" value="XM_024848048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLC8"/>
    <dbReference type="GeneID" id="36555747"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431488"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="60" mass="6616" checksum="63C3E6700371B179" modified="2018-02-28" version="1">MDLDRCGYVNLFPFFVFPSPALAVPLFGPRKWINSFGLDPWAGALGFPEAIGVRVDPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLM6</accession>
    <name>A0A2I2GLM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709075.1">
        <property type="nucleotide sequence ID" value="XM_024848071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLM6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLM6"/>
    <dbReference type="GeneID" id="36555770"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431586"/>
    <dbReference type="OrthoDB" id="5413982at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="73420" checksum="3FB8EAE8D14D7065" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLY8</accession>
    <name>A0A2I2GLY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_420683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709188.1">
        <property type="nucleotide sequence ID" value="XM_024847313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLY8"/>
    <dbReference type="GeneID" id="36555012"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420683"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="300" mass="34573" checksum="7F282A5C669B7426" modified="2018-02-28" version="1">MTELSFPAYPGPKLEAYVSRLLDEAGVPSFLWGESVLAILRVPTADFFSGWVVPDDCIEKASRALDEAKFPPCTLGERCSLFWHHRTHPIPDHHYHTDLEYSETPPHMSCGVFLYKKSRLFWSFPDPPIGRPSPNDPYYVLTSDTRLREGGLTTRGRSQPGDYPVKMPIPARYLEAMILLELRDLVGKVTSAHWKVEINYLADFVLRKENNPALSFEDIAEPFREFVRQRYIDVIYVPGELPDTDFGDKYLHQLYVTLKSNGQLPPLEPTPYDNYIPLELRLQKYDIPFDPKLIDRSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM72</accession>
    <name>A0A2I2GM72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase L</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase L</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase L</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_504835</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709276.1">
        <property type="nucleotide sequence ID" value="XM_024854241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM72"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM72"/>
    <dbReference type="GeneID" id="36561947"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504835"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF28">
        <property type="entry name" value="BETA-GLUCOSIDASE L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014114265" description="Probable beta-glucosidase L" evidence="19">
        <location>
            <begin position="21"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="654"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB53974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="736" mass="78057" checksum="FB65E5F91183F54C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMP8</accession>
    <name>A0A2I2GMP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_372848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709447.1">
        <property type="nucleotide sequence ID" value="XM_024845220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMP8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMP8"/>
    <dbReference type="GeneID" id="36552920"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_372848"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="527" mass="58016" checksum="EBB08DD774F311D4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP76</accession>
    <name>A0A2I2GP76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_23683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709978.1">
        <property type="nucleotide sequence ID" value="XM_024842925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP76"/>
    <dbReference type="GeneID" id="36550624"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_23683"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="163" mass="17846" checksum="24CF665949A3CD26" modified="2018-02-28" version="1">MAIRLKIWDSEPPKPIVSAMDLPPLEQTKNTGSLVVAHICDSTCSTADGSISFSLQLLSHFSAYCRYQCGETVYVPTRRNNILSPLLGSDSFGRSVTQDAHNIATGVRIGFSGKFDFRLFPPLSPTFSREANVQVLFCLPGNPPVHIQNSFGVDLSRPHVVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPN6</accession>
    <name>A0A2I2GPN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_344240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710142.1">
        <property type="nucleotide sequence ID" value="XM_024843448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPN6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPN6"/>
    <dbReference type="GeneID" id="36551148"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344240"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060205">
        <property type="term" value="C:cytoplasmic vesicle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB54840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="597" mass="68618" checksum="E4C16CD93C025172" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPT1</accession>
    <name>A0A2I2GPT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_452481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710186.1">
        <property type="nucleotide sequence ID" value="XM_024851277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPT1"/>
    <dbReference type="GeneID" id="36558976"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452481"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="2"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="476" mass="51662" checksum="F56A13B7397F73E6" modified="2018-02-28" version="1">MVIFCISCITFISCYLGGLVTVSVPQIARDLQLDAGMELWPVSMYALSTGCTLLIFGAVSDAVGSRLVFLLGCFFQSIFCMACGLADDGTQLIVFRVMSGLATAMCLPSAMSIISQNFSAGKLRNLAFSFMGGGQPIGFGLGILIGGVCADTVGWRWGFHSAAIANTVAFLLSWWQLPQHKESRIKWDFLFFGIDWLGAIVISAALALLSLGLSIITGDVNNARKPSTIAYFTVSGVLLICFVLWQEFQERRRKPTLIRNSLWKNAAFTSICINVFIIWGAFNGFEQIINFFFQNVQELSVIQTAIRFIPTPVTGLLSALVTGMVLHRVRADAIMNITTVISAISPLIMALVNPSWTYWRCAFVAICLNSIAADSLFTVSNILIADLFPPETQGLAGGVFNTISQVGKSFGLTFVELIANVVSDNKAAAEERYEPNGLMVGYRVSFWFLFAANIVSLGVGAVGLRKVGNIGKKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQI1</accession>
    <name>A0A2I2GQI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_461076</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710440.1">
        <property type="nucleotide sequence ID" value="XM_024851996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQI1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQI1"/>
    <dbReference type="GeneID" id="36559694"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461076"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000260">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 13" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="15">
        <location>
            <begin position="159"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB55138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="956" mass="107043" checksum="1CF9C2D15DF01FAE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRD1</accession>
    <name>A0A2I2GRD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_443219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710725.1">
        <property type="nucleotide sequence ID" value="XM_024850518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRD1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRD1"/>
    <dbReference type="GeneID" id="36558217"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443219"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="141"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="545"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="603" mass="66198" checksum="0CA20134D887BDFA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRT1</accession>
    <name>A0A2I2GRT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_506141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710875.1">
        <property type="nucleotide sequence ID" value="XM_024854366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRT1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRT1"/>
    <dbReference type="GeneID" id="36562072"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506141"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="307" mass="35173" checksum="C6F59C7DC9787113" modified="2018-02-28" version="1">MSTSSDSEHDSCDELDQRDPDELWQEAMEIDEKYRTRSIAFKELEASLHKLWRGVKKIDASPKEREEAILPNGQRLWTDLPYFVDDIHNFWENVMFDKSVPETKHLNRWLATMSCAGIYTVELLQCSLRLFSGALEEKKVLELMEDSFIKPDGHEYPDVLSVEQMLPLCAIWMKYTGSKLAILSANPPGLDENACISHPPGPFAREAGITDSGLSIGRWQFWRKEFQKFSQKKKWETFSSPAKDCVLWWDRASRRAGILLDEAEESMGSDGTDTEQLRRNMEDMSIGTNFRESAGSSPDIDMGVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS28</accession>
    <name>A0A2I2GS28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_399966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710965.1">
        <property type="nucleotide sequence ID" value="XM_024846304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS28"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS28"/>
    <dbReference type="GeneID" id="36554003"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399966"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="121" mass="13302" checksum="60039ADC14053689" modified="2018-02-28" version="1">MKLVRFLMKCANETVTVELKNGTILHGTITSVSPQMNTSLRTVKMTPKGRDPISLDTINIRGSTIRYYILPDSLPLDTLLVDDQPKPKNKARKEADRGGRGGRGGPRGRGRGRGRGRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRD8</accession>
    <name>A0A2I2FRD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_74018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698494.1">
        <property type="nucleotide sequence ID" value="XM_024855359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRD8"/>
    <dbReference type="GeneID" id="36563065"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_74018"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="12170" checksum="97BE8AE97143BB40" modified="2018-02-28" version="1">MDAGQDGYGFSIFDGHRGAAALDVCFYWVCSPLFRSFVFFFSYVGIPFEGLAIERVSLLAGDLWFLGNWFVPRIPLISRAVPNWAAEMDRSNDCESRDSQASRSALRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRF9</accession>
    <name>A0A2I2FRF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="11">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TAH18</name>
        <name evidence="15" type="ORF">P170DRAFT_419008</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="11">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419008"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000015">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="228"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="67"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="412"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="451"/>
            <end position="454"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="561"/>
            <end position="562"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="567"/>
            <end position="571"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB43197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="646" mass="72758" checksum="C10189A25DE9837C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRJ3</accession>
    <name>A0A2I2FRJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Neutral protease 2</fullName>
            <ecNumber evidence="17">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_441707</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="17"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698554.1">
        <property type="nucleotide sequence ID" value="XM_024850383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRJ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRJ3"/>
    <dbReference type="GeneID" id="36558082"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441707"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 17" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="10 15 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013988265" description="Neutral protease 2" evidence="17">
        <location>
            <begin position="18"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="19">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="367"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="388"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="190"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB43252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="515" mass="54244" checksum="4FA708B46F45E978" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRY4</accession>
    <name>A0A2I2FRY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_481314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698668.1">
        <property type="nucleotide sequence ID" value="XM_024853857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRY4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRY4"/>
    <dbReference type="GeneID" id="36561555"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_481314"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="213"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB43366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="308" mass="33438" checksum="1A5AAB3E4358AC71" modified="2018-02-28" version="1">MAEVKHRIPSPLLPTIPGTTRIDYPKWFGGSASCMAVVVSHPLDLVKVRMQMDGGARQGTAKTAIRIVQSEGISGLYSGLSAGLMRQLTYGSVRIGLYESIKEKCRENGISLNAPALAMVAATTGFVGAMFGTPSDIANIRMQNDRSLPPASRRNYAHVLDAWVQMKRTEGWRAFTQGLWPNCVRCAGMTASQLASYDVFKGLLMSFTGTKNEHPVLHVFASLLASLVATTVCSPMDVIKTQLMGSSGQGSTLKVIKELTATEGLKWIFRGWTPSFVRLGPQTMATLVLLEQHKRMYRAIKGVDGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS01</accession>
    <name>A0A2I2FS01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_514626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698703.1">
        <property type="nucleotide sequence ID" value="XM_024855230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS01"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS01"/>
    <dbReference type="GeneID" id="36562936"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514626"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="170"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="413" mass="45939" checksum="8C86C5EAEB302241" modified="2018-02-28" version="1">MVFSANGICCSLRLDQSRVFLPSTQQTETKPSISGTLCLSLSGDTPIRGISVQVKGQTKLPFQEGIISSTSHEEVTFVRSQTLASSKKMASFILPAGKYEFPFDVPLDPNMHETIAGPNHEYHSYKVYGIIERRFYRNHVVSEPIRIYRPAVEDSSVILLSDPRVAEDLSEATIPYSISIPHKKIPFGSTFPVNFWMAPLNKGLKMKSINLAVVEKHSIKIEAPAAYATRYGVRHLTSAKDHILFTEHHEEHEDDYLAPASEWYDIEWSTTKAVSLPKSLNECTQRVKSNHIQIHHELVFTVELLHAEGRRTLIRGSLPFSIVMLPELNTPDGAVCGFTLEQFLHDYDSPPPLYGAHTSDPMLTGNLAGVESSSEGQNESLTAPADLPWAPCYDLIFGCSPDYETLSLPQGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS26</accession>
    <name>A0A2I2FS26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_514649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698737.1">
        <property type="nucleotide sequence ID" value="XM_024855236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS26"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS26"/>
    <dbReference type="GeneID" id="36562942"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514649"/>
    <dbReference type="OrthoDB" id="2563500at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="637" mass="71428" checksum="D1EC0096C022702B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FST8</accession>
    <name>A0A2I2FST8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_393580</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698986.1">
        <property type="nucleotide sequence ID" value="XM_024846026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FST8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FST8"/>
    <dbReference type="GeneID" id="36553725"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393580"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="236"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="803"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="896"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="920" mass="101701" checksum="18130DA731595B35" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSX8</accession>
    <name>A0A2I2FSX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_480692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699037.1">
        <property type="nucleotide sequence ID" value="XM_024853806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSX8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSX8"/>
    <dbReference type="GeneID" id="36561504"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480692"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014131040" description="superoxide dismutase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="215" mass="23577" checksum="7274D71A0A46F0D3" modified="2018-02-28" version="1">MRCLSLVSSALLGFSLAATVSAGPVPKNAPVIEDNDPEFMYQAKLLDKDNSTVTGQFTAWATDVGVGIKFHVEVEGLPDGSLHYPYHIHEKPVPKDGNCYATGAHLDPYKRGDQPPCDIKAPQTCQVGDLSGKHGPIIAPDDETYEVFYTDYYLSNQKDDPAYFGNLSIVVHAPDNTRLNCANFVPLNTLKSEDSEQSEQSEDSEDPKDPEELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT00</accession>
    <name>A0A2I2FT00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Suppressor/enhancer of lin-12 protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_441214</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699067.1">
        <property type="nucleotide sequence ID" value="XM_024850266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT00"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT00"/>
    <dbReference type="GeneID" id="36557965"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441214"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014182539" evidence="9">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB43765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="203" mass="23536" checksum="C4D774810580F3C2" modified="2018-02-28" version="1">MRFSAATLLITALGWITAATAHNIQLKAHSRECFHESLHKDDRMTVTFQVGDREFGGSGNLEIDFWVEDPSSNRQYYRQAVSSEDYSFNAHADGKYVYCFSNEGWTSNSKEVSFNVHGIVYVPETEMEQDPLETEVRRLSEALAQVKDEQSYIVVRERVHRNTAESTNARVKWWSIFQLAVLIGEGVFQVWWLKRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT25</accession>
    <name>A0A2I2FT25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699063.1">
        <property type="nucleotide sequence ID" value="XM_024850264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT25"/>
    <dbReference type="GeneID" id="36557963"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441207"/>
    <dbReference type="OrthoDB" id="4447358at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190665" evidence="1">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="135" mass="14403" checksum="F71F8F994F2FF190" modified="2018-02-28" version="1">MPSIINPTTLLVALLSATSTVAQKGYTGTITTEGIGNCPLTQHAENHIAYTWEPTNGSVCVELGRPYADGYHAGLFGEVETPESVKPPHFGGCRDSKCTDCTLVDIEYGDEPGLIKVDCLELKDAPYLFVGVGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT62</accession>
    <name>A0A2I2FT62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_62655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699106.1">
        <property type="nucleotide sequence ID" value="XM_024855307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT62"/>
    <dbReference type="GeneID" id="36563013"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_62655"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="363" mass="40215" checksum="4654BD60A854DDEF" modified="2018-02-28" version="1">MADTQSIENWVLQVAPAGSPRKPQDGIERDDGMLPASTPSSRVSVTGSERTESSATDKQANSCHETPLCVLEEYGVYRVGVPTKTTNALSPTDAMKDLKDRILAADQTAMDRPQATLSQYYASAARIGYWMDQTVGKGSTKPQVDALTAVLSGCPDTCGVDIFNVEGLPISPQYRLVSPSREPLHLCPDAVISVPTGDRANRVNKFFTATKHRYSLCPLPRLEYMSALLLHAIQFRMFSEDPIGPIRQCLGYIGASLRMFAELAEKAGIDLTQDPIPACVAMEYRFCMWHFTVVALHEDKSHGKVILFEEIPRVDLNPRRPDDLCSLTEVFKAIAIHANEVWWSWVERLMDNLDQGRPTEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTB8</accession>
    <name>A0A2I2FTB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_418226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699153.1">
        <property type="nucleotide sequence ID" value="XM_024847205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTB8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTB8"/>
    <dbReference type="GeneID" id="36554904"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418226"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="729"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="741"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="844" mass="93747" checksum="EC15BAE60508F93B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTJ4</accession>
    <name>A0A2I2FTJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_430903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699199.1">
        <property type="nucleotide sequence ID" value="XM_024847994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTJ4"/>
    <dbReference type="GeneID" id="36555693"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430903"/>
    <dbReference type="OrthoDB" id="4431916at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="397" mass="43594" checksum="84EEF5DF2E111F12" modified="2018-02-28" version="1">MTANASKLLLIFAKKNNQILPLNCPGLPITDSCPIIATGKKNFVTDPLLLLHISSSIKSKPAKYGGYFFHLSFQDEDKQFYYVILQKGDSDVAETKSASDPITNESGWADDDHLAGGWDVLHHPDIQAIDQTEWCSTHPDPAVDSHDGDSVRHDTHEDAAVTCTCGHMGGWDCHCHSFDGPVKHDAHEDTAAKLAGDHGNSWGCGCDENSWGCSCIEYDWMCQCHDATQRRDSSRVAHTHEMKDHDEGDDRLPHAHPASYVRSKRAHRRRKHNVNKDVTSWYTEPSTQVAESGCSPSTKRFLRSRFGSTKKVASTRGDGRENGNWTAVGDSSVGGWSVDYDYSDTKSPPSSAGPRAPSPATVVSSRATEADRNLSEYDDTASGDNLNRAANNFTSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTK0</accession>
    <name>A0A2I2FTK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_368714</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699254.1">
        <property type="nucleotide sequence ID" value="XM_024844876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTK0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTK0"/>
    <dbReference type="GeneID" id="36552576"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368714"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="349"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB43952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="509" mass="57327" checksum="34A66B1EAB68454C" modified="2018-02-28" version="1">MSATARAATLRSQVPNLKASYGNAVALQRSVIQSASYTTSPAARSSLLNNSERPVSQILSPYAALPLTRSFHAATARWQEQQQKQEQQKENKSEDTNQEKNEESKDQEKEDGKKEEAPPPPPHGDKTPWQVFRETLQTEFKASKEWNESTKALASSAHEFSENENIKRARAAYEAASGAASTRTSSAFKTTGQAIGKSAAWTWNTPVVQGIRKGVNATGSGLEKATRPVRETEAYKSVKDAIDDGSSSRYGGWIEKEERRKQRQRREELEAKAGRRVEPMVEDPNAGTHVTLHKDSAWKESWRDFKDSNPMMQKLFTMKETYNESENPLISTARSISDRVAGFFAENETAQVIKKFREMDPNFQMEAFLREMREYILPEVLDAYVKGEAETLKLWLSDAQFHVYAALAQQYNTAGLKSDGRILDIRGVDVSHARMLDPGDIPVFVVTCRTQEVHVYRNVKTNELAAGMEDKVQLVTYAIGLTRIPEDVNNPETRGWRLIELQKAARDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTZ8</accession>
    <name>A0A2I2FTZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_70825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699388.1">
        <property type="nucleotide sequence ID" value="XM_024855342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTZ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTZ8"/>
    <dbReference type="GeneID" id="36563048"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_70825"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="136" mass="14951" checksum="ABD6FED466C0430E" modified="2018-02-28" version="1">MTRSHKANDRDHSLINNAPATPHEQLSRFFTKSGPVDADPRKTKKNGGGKRNWGRSGDEVQDYDYTLTNARRYSNSSARGIGEFRTKFETTELEPVFKSNLHEPLNATSAAGGDVASKHSSIMNSSKDNGVHNSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU70</accession>
    <name>A0A2I2FU70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_368434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699495.1">
        <property type="nucleotide sequence ID" value="XM_024844860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU70"/>
    <dbReference type="GeneID" id="36552560"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368434"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="112" mass="12442" checksum="E760DC86709862BA" modified="2018-02-28" version="1">MVLEVGYSEGLGRLRVDCRWWLSRSEGQVKIALLLSIDSDRPYILIEKWENTPPIHGHSCRVPRQLAPQRIAAVTVALENSQYVVTGAPLHLSIDDIVIPPVPSTIPPIQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVJ6</accession>
    <name>A0A2I2FVJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_318344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699947.1">
        <property type="nucleotide sequence ID" value="XM_024843295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVJ6"/>
    <dbReference type="GeneID" id="36550995"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_318344"/>
    <dbReference type="OrthoDB" id="5381783at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="407" mass="45964" checksum="C3D4543CE464E5E3" modified="2018-02-28" version="1" fragment="single">MSSFKTTLRAVCAAALSTMVEARSELPLSSTDPKASLKEDTEVTFDPLGVAAVLHNPRANNSAAMLYTQSDHGIFTWPHTMMIGGTLPAMKMLVDHLTEEMKSTHPAITMCAQITTMLPVRSDVSGSVFRELPLDSSNAWLNHVVSFKASPKPGNDFAVVCVDGIREDVHVRKQRVKDTIGSLRWWIATLTLDLISLLNGLMMVTGLVMGVLVADIWAAVLFFLYWCHWLGTMLISFQSMVQKDKPHINKDERPRYAIYQRKEGGTVIFKGRQDQLEDWARSTWEYRPRLDKNCLHWMWITTGTLSAFCSVACMVNMRSYMQLGFLGVLVYASLAEILAIRISRSLQKKAKGDDIHEAYVLESETRSKAIIRATLEIKRTCRLEGLNWIELNLLPPMFVFEEMQKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVR0</accession>
    <name>A0A2I2FVR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_265659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700031.1">
        <property type="nucleotide sequence ID" value="XM_024843115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVR0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVR0"/>
    <dbReference type="GeneID" id="36550814"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_265659"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="378" mass="41030" checksum="01A6874086BF585D" modified="2018-02-28" version="1">MASAFSFGFSGDDIDIDDSELNGIEDGNVSLPQDNKNELPSLVEARKHDMKEWVSTLPSQISYNRLELNGLPNRAQGKPLSLARREVFDIRTQLMAEDTADHENEQLIAGLEKGDIKPQFYEGGFKTWECALDLAKLVVSEDHLSGSAGESLEGRHIIELGAGTAVPSLALFAQLFSESTPSGSQRKSHFTFADYNSAVLRLVTLPNLLLTWNHIVTAQNSPLAEATSPEGQTEEEEELDITPELIESFEKDLASRGITIEFVSGAWSPTFVDLVLSSPEKAKSRTLILASETIYSPASLGAFSETLLALLRATEANTQSRALIAAKRVYFGVGGGVDEFLEVFKGVGGGELEVTEQLNIKSEGVGRVVLEIATRSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWC5</accession>
    <name>A0A2I2FWC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_450012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700251.1">
        <property type="nucleotide sequence ID" value="XM_024851086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWC5"/>
    <dbReference type="GeneID" id="36558785"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450012"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="370"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="720" mass="80089" checksum="7FAE80DDFD5D464B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWL2</accession>
    <name>A0A2I2FWL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent rRNA helicase RRP3</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P170DRAFT_440174</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the SSU processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700307.1">
        <property type="nucleotide sequence ID" value="XM_024850015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWL2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWL2"/>
    <dbReference type="GeneID" id="36557714"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440174"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="79"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="274"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PLB45005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="468" mass="51954" checksum="865EBC2090FB7537" modified="2018-02-28" version="1">MAPVSKQRKLNREPATKKAPPTSPSPSPEPEESKENEEPEVAEEEAPKTFKELGVIEQLCDACTELGYKAPTRIQAQSIPIALQGRDLIGLAETGSGKTAAFVLPILQNLMESPQSLHSLILAPTRELAQQTSQVVEALGSLISVRCTLLIGGVDMVSQSISLGKKPHVIVATPGRLLDHMENTKGFSLRQLKFLVLDEADRLLDMDFGPLLDKILKILPKQGRHTYLFSATMSSKVESLQRASLVNPVRLSISSKYQTVSTLIQRYVFLPHKYKDIYLVYLLNEWAGQTGVIFTRTIHETQRVTLMLRNLGYGSIPIHGQLSQSARMASITKFRAKARNLLIATDVAARGLDIPSVDFVLNYDLPQDSQSYIHRVGRTARAGRSGIAISFVTQYDIETWMRTEKALGKKLDEHKIAKDEAMVFAERVGEAQRSAAIEMRDMDEKGRGSKFRQKGGKRSRDGMDEDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWW3</accession>
    <name>A0A2I2FWW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_366733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700420.1">
        <property type="nucleotide sequence ID" value="XM_024844770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWW3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWW3"/>
    <dbReference type="GeneID" id="36552470"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366733"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="372" mass="42413" checksum="02C9B9CB50D79FC5" modified="2018-02-28" version="1">MADDKKPSVLIVGGLGFIGRHLALYIHENNLASEVRLVDKVLPQLAWLAPEFEQACSKDKFVQADAGREQHFPRIFDRSNGEQFDYVINCGGETRHSQPDDVYELRSYNLTVALAREVARRGIRSYVECSTAHVYKGGSGPRKEDDKIQPWNKLAKWKLKASEEIQKIPGFTYCVLRLPHVYGEYDPGYFATGICLARVHQDIEKDMEMLYTKDLKINTVYVKDAADALWKAAEWRANTPPREDQPIAFNVVDHGDTRQEHIAEALLDVLGIKCSFLGSLASQLAKMNLDDVLDDMNEDCLQIWAELIEQAKIERPGPISPFLERDVVKDQDMSIDGTLFEKTTGWKPTREKFDADGVRDMVESYKRMGWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY93</accession>
    <name>A0A2I2FY93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_457902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700890.1">
        <property type="nucleotide sequence ID" value="XM_024851750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY93"/>
    <dbReference type="GeneID" id="36559449"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457902"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="250" mass="28435" checksum="0F598F6C1C6C4023" modified="2018-02-28" version="1">MAPIRRYLRISKYTILECRIYLDNPSDTRWLLDSRDPVLPRIFAAIRPLVLPKLREENERLFARKKGHPVKDVIAEDEFEVALFLRESRTRHSLLTRHKEFEDQGHGTGVGRNKGKNPEAGTQADTGILVESESEDESGLRNIPQAGTDEDEDGGETSGKRRRATAGSSGDDVRVSKRQKDQDWGDDDGEDKKMRFRTNYEGFNIYGWTLCLLVTRKGGRARPAATPSEPSRQALMEEWMSTQQGDVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYB9</accession>
    <name>A0A2I2FYB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_314713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700929.1">
        <property type="nucleotide sequence ID" value="XM_024843276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYB9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYB9"/>
    <dbReference type="GeneID" id="36550976"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_314713"/>
    <dbReference type="OrthoDB" id="4469984at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="188" mass="21653" checksum="741574524591A144" modified="2018-02-28" version="1" fragment="single">LFLHGTRPEQKRALHQPGAELDVVFDLVGHVLILRETIKNPEIVETAWTLSVHIKCSKMHFINLRGLEDGSLQLSLQMKRSACLAKGNKMVVKQKSQGFAAPHLESRLFADFYSCNWSKQRIELFLPEERIKGWKTAALILRTFKEITSAHWCHMVNIVKPPPVSVLDWRGLVEYLWAVEKKEKETVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ28</accession>
    <name>A0A2I2FZ28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_449476</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701191.1">
        <property type="nucleotide sequence ID" value="XM_024851046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ28"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ28"/>
    <dbReference type="GeneID" id="36558745"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449476"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB45889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="680" mass="72723" checksum="FC3154FCD6E8B95B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZB0</accession>
    <name>A0A2I2FZB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_390336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701267.1">
        <property type="nucleotide sequence ID" value="XM_024845900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZB0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZB0"/>
    <dbReference type="GeneID" id="36553599"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_390336"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="99833" checksum="B197F8ECE166E818" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZQ5</accession>
    <name>A0A2I2FZQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Metallopeptidase MepB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_390586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701409.1">
        <property type="nucleotide sequence ID" value="XM_024845909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZQ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZQ5"/>
    <dbReference type="GeneID" id="36553608"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_390586"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="221"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="716" mass="81610" checksum="57F046FF0C2DC29A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZS4</accession>
    <name>A0A2I2FZS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_500936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701378.1">
        <property type="nucleotide sequence ID" value="XM_024854155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZS4"/>
    <dbReference type="GeneID" id="36561861"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_500936"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="14323" checksum="AB831F7A5851D1C0" modified="2018-02-28" version="1">MSGHFASIRPSPDVFYNLIATSDLTALMDGGDAECENCHRRKSQLKLHAKHHHFSTQCRKVLCDLCFEYFIRNGKMRNPKLNGILSVRRQLQQDRKAGQRIACTKGDCMAVEHKSDLKKFVVSSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0B8</accession>
    <name>A0A2I2G0B8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_365047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701578.1">
        <property type="nucleotide sequence ID" value="XM_024844681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0B8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0B8"/>
    <dbReference type="GeneID" id="36552381"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365047"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000439">
        <property type="entry name" value="Non-ribosomal peptide synthetase OfaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="588"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="954" mass="106400" checksum="BFE65A759C52EAA4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0F1</accession>
    <name>A0A2I2G0F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_477232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701652.1">
        <property type="nucleotide sequence ID" value="XM_024853430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0F1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0F1"/>
    <dbReference type="GeneID" id="36561128"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477232"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="202" mass="21230" checksum="C2B94E12B9296739" modified="2018-02-28" version="1">MSSPGQSQVQLQPPKGPGAVEKDPQGLATSDDGPDPGEHLEGARMYSVTAALLTAIFLGTLDASILATAIPQITARFHSTLDIGWYASIYMMATCAILPMAGMFYSYFSAKYTFMGFLFVFELGSLLSAAAVSSKMLIVGRAIAGLGSAGIYNGGLTIMGERDEAIDPGLANWTRDLGGDHGIGVWPSDRRCFDIAGLVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0M9</accession>
    <name>A0A2I2G0M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_438238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701746.1">
        <property type="nucleotide sequence ID" value="XM_024849550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0M9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0M9"/>
    <dbReference type="GeneID" id="36557249"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438238"/>
    <dbReference type="OrthoDB" id="4239773at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="283" mass="31139" checksum="D1381E01522A06BF" modified="2018-02-28" version="1">MSSFILTLSCPDRPGIVHAVTAYLVENNLNIVDSSQFGDPSSQRFFMRVHFAAESADKTVDELRTAFSATAASLSMDFQLVPASQKARVLIMVSKIGHCLNDLLFRQSTGQLAIEIPLIVSNHPEFAALAATYNIPFVHLPVTADTKPQQEAQILDLIRQHNIDLVVLARYMQVLSPTLCEAMSGRIINIHHSFLPSFKGAKPYHQAFDRGVKIIGATAHFVTSDLDEGPIIEQNVVRVNHAMSPKELTHAGSNVESNVLATAVKYVTERRVVLNGHKTVVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0P2</accession>
    <name>A0A2I2G0P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_411693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701754.1">
        <property type="nucleotide sequence ID" value="XM_024846907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0P2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0P2"/>
    <dbReference type="GeneID" id="36554606"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411693"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="388" mass="43233" checksum="F4C7BC0C0838406A" modified="2018-02-28" version="1">MVDSKVPQPGPAKLKRNAGPDEWLEAAKDCKYLSEPHMKQLCEMVKEFMMEESNIQPVSTPVTICGDIHGQFYDLLELFRVSGGMPDQSDVEAPKTSPSVITSDDLEPPSSISDPKLRKKLRKSGGSEDAGDDSSNASRERSSSAGSSDISVNRNFVFLGDYVDRGYFSLETLTLLLCLKAKFPDRVTLVRGNHESRQITQVYGFYEECFQKYGNASVWKACCQVFDFMTLGAIIDGRVLCVHGGLSPEIRTLDQVRVVARAQEIPHEGAFCDLVWSDPDDVETWAVSPRGAGWLFGDKVADEFCHVNDLTLIARAHQLVNEGYKYHFANQNVVTVWSAPNYCYRCGNLASVCEVGEDLRPTFKLFSAVSDDQRHVPTARPGRSEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Y2</accession>
    <name>A0A2I2G0Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_477414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701835.1">
        <property type="nucleotide sequence ID" value="XM_024853458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Y2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0Y2"/>
    <dbReference type="GeneID" id="36561156"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477414"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF42">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="527" mass="58213" checksum="A55EF66C6724687D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G138</accession>
    <name>A0A2I2G138_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_362147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701880.1">
        <property type="nucleotide sequence ID" value="XM_024844513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G138"/>
    <dbReference type="STRING" id="1392250.A0A2I2G138"/>
    <dbReference type="GeneID" id="36552213"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362147"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="448" mass="50196" checksum="126D9B7ACC3D9386" modified="2018-02-28" version="1">MRTIWKTTDSGDGYDRARLDNVFNMERPAHFPRAVVTATCTEDVIGAVRMALDQPRKCRVAVRSGGHSFFVWSLHDDSMLVDLGSWKEIVVDADTGIAEVTPGVTGAELNEYLRAHHGCFFPTGHCPDVALGGFLLHGGQGWNCRGWGYACDKVVGVEVVTAQAELLQCNEDENTDLFWAARGAGPLFPGIVTKFYLQLLPDLTGHIRSSAYIYPASIYHEAFEWVQSIVPDADRDTEIVIVAFHSDVLGETCLKIHFVAMKSNPLESEYALTEIHRSRPAGTITESVSQKDTMKHLYEDQIHANPKDHYCYTDDYFISNSANVTEVLEETCLTIPAGKSFAFWYPLYPRSRHTVSDMALNVPSDHYFVVYAIGSDRDEAARSKAWAQESMAKVKEHAVGSYLGECDLKMAYDWYWGRSAQRLATVRHSRDPDSLFCTVHEGSDRDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G166</accession>
    <name>A0A2I2G166_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_466052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701888.1">
        <property type="nucleotide sequence ID" value="XM_024852381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G166"/>
    <dbReference type="STRING" id="1392250.A0A2I2G166"/>
    <dbReference type="GeneID" id="36560079"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466052"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="554" mass="61548" checksum="6A34E88E29C8FCF6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1L6</accession>
    <name>A0A2I2G1L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcription factor SipA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_363347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702069.1">
        <property type="nucleotide sequence ID" value="XM_024844572.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G1L6"/>
    <dbReference type="GeneID" id="36552272"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363347"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000079">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000349">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="305"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="919"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1386" mass="156412" checksum="74A2BA60E9DBD8E5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1Q5</accession>
    <name>A0A2I2G1Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="10" type="ORF">P170DRAFT_457278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1Q5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1Q5"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457278"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB46812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="299" mass="32693" checksum="3758228BFF0DEDE2" modified="2018-02-28" version="1">MSSSDKPPTTTARLNQPPTLALLVYPVTLIVGSLFSVLSPTAQGSRDHAIDHTGPLAPTIAADLNLSQPPVNYFARKDNIFNVYFVKLGWLWTTLAFSLLLVSLPSYTTPSSQRPRRIGQAIARYALATLVWYLTTQWFFGPAIIDRSFVFTGGKCERVVPLAEGEDSPSFHTLFTAAACKSAGGSWRGGHDVSGHVFMLVLATSMLVFETVGALASENGAKKPENGDEKSAGLKTLTVRFAWAVSGLGWWMLLMTAIWFHTWFEKLTGLLISLGTVYTIYILPRRSIPWRDAVGLPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1T5</accession>
    <name>A0A2I2G1T5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_319685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702135.1">
        <property type="nucleotide sequence ID" value="XM_024843303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1T5"/>
    <dbReference type="GeneID" id="36551003"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_319685"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="360" mass="39417" checksum="D4CE8513A34A2042" modified="2018-02-28" version="1" fragment="single">MSQRTRFVCVSDTHAYTPSEAGFKLPAGDVLIHAGDLTNQGSKSELRKTMNWIAAADFEVKIVICGNHDITLDAAFYAEHGSKFHGQHLEDPQECMDVVIKASPSIVFLRHQSAIVRLTRPDGPNTVFKVFGSPFSQSPGTWAYGYESTHAAALWDQIPLDADLVVTHTPPHSHCDSRAVGAVGVGCKALRQALSRVRPLLAVCGHVHESRGFERVRWSQSSASSSPSSNARFKESDEDQVVKGELPVPGSKKQSLVDLTGRKAQRLDNHGCATIESGMSSSQDTLAFPCPMDQPLPRSRAHEQETKSPPSCPQPARQKPRPQRRETCIVNAAILATSWPHRGGKRFHAPIVVDLELPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1Z8</accession>
    <name>A0A2I2G1Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702214.1">
        <property type="nucleotide sequence ID" value="XM_024849639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1Z8"/>
    <dbReference type="GeneID" id="36557338"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438614"/>
    <dbReference type="OrthoDB" id="4221933at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="274" mass="32023" checksum="F927812D40BE9FDE" modified="2018-02-28" version="1">MDAWQRNMRMIHQISEFVDFDSAESDLVADFISLIQAMREGLTQIDDDFNIPDSQINTLFLTKLKARSEWDEWATTMLRDNRINAPNPEHRMTFQELSELAIDHERVLRGGKGRYETRKVLPDEPLSIGPPPSNIPTVPEDVTQDDINAFVVQQMSQEDGYPRRRHTVRGHNKNPSQEEINDYVIHQMRRNNEPQKPRNRSQSQPEPRSQNHLKKSAGPRCTFCGDPHHQTNHCWRRWRVAVEAPPGDFVPKRIEYRTEIPGQPPMYRTGFTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2R5</accession>
    <name>A0A2I2G2R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_511816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702476.1">
        <property type="nucleotide sequence ID" value="XM_024854928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2R5"/>
    <dbReference type="GeneID" id="36562634"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511816"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="124" mass="13396" checksum="CBC76B24CFBF24BB" modified="2018-02-28" version="1">MVVDHHSAVELLAAQHYALPTVGSSEAFLLPELAVWNDGGEPDVRGRTSPCVSQIAQYFSIEPLFTTVSSSSGYVIDSVLVQIRVGRNGLIGRFLRLGSAHMGHFDLGPDMAAHLDESQCRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G322</accession>
    <name>A0A2I2G322_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TOR signaling pathway regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_511901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702577.1">
        <property type="nucleotide sequence ID" value="XM_024854934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G322"/>
    <dbReference type="STRING" id="1392250.A0A2I2G322"/>
    <dbReference type="GeneID" id="36562640"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511901"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="358" mass="41425" checksum="F29F17FE5C909D98" modified="2018-02-28" version="1">MSAMEQPQNLRSLFNEAKAEKTALEVRPDTNTDQYRNDVSATIAKFEECHRLVSLLSLFSSNEPLEDITTGDLQYLTVDYHLADLVQRSYSSDREASLRRALQQYERYLTRLDDYELLNDSNKKLYERYTENPSTFSLTPVNDAATRREVKITRFKEEKELKQRLEYISNNQGQLQSDEDDVRQLYLAEIHLYIHQTFQSLDLISQELTMLSSVRNMAPNPDQTQRDDPRSRNTAGRSTYSDRLDPPISQLLQGGRFGPILSKEGKPMQPFTLLDRRTQLQQGVFRPSHNLPTMTIDEYLDEEKRRGNFVQGGESSGIQPEVDEDDFDRADEETMKARAWDEYKEANPRGSGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3B8</accession>
    <name>A0A2I2G3B8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_511980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702670.1">
        <property type="nucleotide sequence ID" value="XM_024854947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3B8"/>
    <dbReference type="GeneID" id="36562653"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511980"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="2">
        <location>
            <begin position="30"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="232" mass="26035" checksum="7B06B084DA480F6C" modified="2018-02-28" version="1">MEFPLSSITPQFPIPFTAFANPTTEPPNLQHLIHHLNLSPHIEGGYFRETDRARDQIVCPAHEHEPTHPHPPDPRARPGEDHRALSTTCLYLLTPKSPIEAFHRTRGRVVHTLHRGRGVCMILKNGARIGKESSRIEIESFIVGQDVAKGERLQWVVEGGCYKASLLVPDGDGDEGEKSGGLLVSETVMPGFEYRDHEFLTRRELEGMLDPGEAKQLGWLLRENFTHGSDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3E3</accession>
    <name>A0A2I2G3E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_439071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702700.1">
        <property type="nucleotide sequence ID" value="XM_024849754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3E3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3E3"/>
    <dbReference type="GeneID" id="36557453"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439071"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="556"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116138" checksum="8C7E3DF200FA8BA2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3X0</accession>
    <name>A0A2I2G3X0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_409748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702870.1">
        <property type="nucleotide sequence ID" value="XM_024846805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3X0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3X0"/>
    <dbReference type="GeneID" id="36554504"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409748"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="327" mass="36183" checksum="9D779DAC8CB4BCEE" modified="2018-02-28" version="1">MVNTLPFRDIQVASPGFGAMGLSFGLGTNLSLEEAEPVLLKAIELGCTFWDTAVVYQAGVNEKLLGDFIRKHNVRDKVFIASKCGFDVFGEGGVTNSASHIKEYIEGTIERLGFTPDLYYLHRIDPNTPLEESIPALDEIRKAGKTKYIGLSECSAATLRKANSIAPIDAVQAEYSAFETLHETDGLIDTAKELGIAYVAYSPLGHGWLVDDFQYKSPEDFAPDDFRRKIPKFQGENFYKNRAIVDEIKKLAVRKGCSITQIALAWVAAQGMIAIPGTTKAARLEQNWASRNVEFTEEEKKEMRRIIDAAKPQGNRYAPAQQAMVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4D1</accession>
    <name>A0A2I2G4D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_359994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703039.1">
        <property type="nucleotide sequence ID" value="XM_024844391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4D1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4D1"/>
    <dbReference type="GeneID" id="36552091"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359994"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="82" mass="9566" checksum="5FB0F25D30636BCD" modified="2018-02-28" version="1" fragment="single">YTDAQAAEVWRFGITSWDCICNGEKSQKARKAFLDHHSYVRKVVPPERLLELHPQDGWKPLCRFSNPSELRSSYPVTNDTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4Y3</accession>
    <name>A0A2I2G4Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">V-type proton ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_476593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703242.1">
        <property type="nucleotide sequence ID" value="XM_024853366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4Y3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4Y3"/>
    <dbReference type="GeneID" id="36561064"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476593"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="75" mass="8543" checksum="B2D54D6A3B2CA17B" modified="2018-02-28" version="1">MANGWSLVIGLIIIVVASVLAWVFSPKGENQTLFRSTLILSFVSCYLMWAIVFMAQWHPLITPKRSNIRPERVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5D0</accession>
    <name>A0A2I2G5D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_386308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703383.1">
        <property type="nucleotide sequence ID" value="XM_024845761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5D0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5D0"/>
    <dbReference type="GeneID" id="36553460"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386308"/>
    <dbReference type="OrthoDB" id="5377172at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53123" checksum="5A9A0D223ADF2855" modified="2018-02-28" version="1">MLSLGALAADNWPYQTFTTAPWRVPQLNINETGDVGQGYIFLALQGEQASSVGPTIYDGNGDLVYQGSHANARGFRVQNVAGQDMITFWSGQYVDPGYGYGTVHVLDNAYNELYTITLKDNYITPDGQTKLSYLDAHEHHVTARDTILVPVINVTEHDLSAVGGQPGHYVAGCLFYEIEVKSNDILYSWNALDHIPIELSEVDLTGTGTRELPFDPYQLNAIAPTAHGFLVSLRGFSSVFYLNRDGSVRWQLSGINGGDFELDEVSFSWQHNTRVYDETDESLTLSLLSNANNDHESNGESIAMILHVDLINRKVSTIREVSDPNDPIHSKNGGSLQLLDPATSQSRLFVGYGDVPELKEYGSDGKVVFSVQFGHPGHIGSSSASKSRWRATPFWKPTGVAKKISDFASDVYMSWNGATEYDNWAIYSVPSQDSDETTFLTSQRRDGFETRISIRVTDFSYIRVAARQGQVSLGISDAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G608</accession>
    <name>A0A2I2G608_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_456874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703610.1">
        <property type="nucleotide sequence ID" value="XM_024851656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G608"/>
    <dbReference type="GeneID" id="36559355"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456874"/>
    <dbReference type="OrthoDB" id="5412502at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="351" mass="38886" checksum="3F149C434B7D73E3" modified="2018-02-28" version="1">MGLDFPTTHGDWKFDLVGLLAIIGESIIDEVVQPLTASRTVLLPRLLPAPHALIRPSRRAALPSTPVTVVGIHTGIQLQSVPYFPSIIHQLDLIQPFEFQEMSIKMAYTEEPASHGTHDKLATVRALAPLKVITILIVAIPLVSFASSFHSAASFWQSDAKPRVSGTNPPGDLALRTREGAFIVVHCSQEVARLLYTGEGRCRYVAGAAYRVLIYVGTLFLMVGIVVMSNCSWTMQVTLGISYLALNVVYMFCALTPEVSRLWHWELRMIDAVMNTTIQSSNYTEVLWHGIRATKSIEWIKKGGFAPATKAWDKWLDEAVRNCENPGWDAVDDTNWKQSTASTTIPHAHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6J1</accession>
    <name>A0A2I2G6J1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_477112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703799.1">
        <property type="nucleotide sequence ID" value="XM_024853417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6J1"/>
    <dbReference type="GeneID" id="36561115"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477112"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="150" mass="16570" checksum="DF6C5800E4C545C5" modified="2018-02-28" version="1">MSLGVIRRFDVANMLSPDQALSLAEIAARMGLREGRINHVLRYARLSRAQQGVCGSHYALDLVAIVRWGRFSRSLQGDLVVFKGFALADNVDRTLYDVLHDTICANRSANKTATFDRGPRFSAPQIVNGYDWAALGNLAGEWWISVDSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6W8</accession>
    <name>A0A2I2G6W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_446495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703923.1">
        <property type="nucleotide sequence ID" value="XM_024850801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6W8"/>
    <dbReference type="GeneID" id="36558500"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446495"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="738"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB48621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="793" mass="89106" checksum="4C1F34C493FDFB2D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G708</accession>
    <name>A0A2I2G708_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_356740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703965.1">
        <property type="nucleotide sequence ID" value="XM_024844172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G708"/>
    <dbReference type="STRING" id="1392250.A0A2I2G708"/>
    <dbReference type="GeneID" id="36551872"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356740"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="244" mass="27173" checksum="F32052B7DDF65BDA" modified="2018-02-28" version="1">MGANARGQTYIDVSSVLVALSTAIVAVRIAARWIKSTLGWDDYVICISIVLAYSMLAEAVFWARDGGLGKHMTDLSDEEKVTFQKCFFANEISYTLLVPSIKISILLLYRRIFPVRKFQIASWIVTGLVCSWCLAVFLTVLVQCRPISLNWDKSQEGTCLDAKQFFFGNAISNLLIDVVILTMPIPMVLQLQLRTSQKLTILGIFLLGGFVCVASIMRVVTLKIFQNEDTSCTPLSVPSPRLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G714</accession>
    <name>A0A2I2G714_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_425682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703947.1">
        <property type="nucleotide sequence ID" value="XM_024847659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G714"/>
    <dbReference type="GeneID" id="36555358"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425682"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014119884" evidence="2">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="149" mass="17323" checksum="986418306613A619" modified="2018-02-28" version="1">MKFMHILFVALFSMALAAENAEPTTLGRCGDYCRRDRDCEGRGRCDYCHRKMNKGKEMRGQAKAKRKEEGKASRQEKKQTNQSTYMHKSFHPFLTNPRLLPHALPHGIIRVVKIIRHFFIRDLTGSPHFRQHDIIRVIFKTTDPISSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7G3</accession>
    <name>A0A2I2G7G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_475148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704117.1">
        <property type="nucleotide sequence ID" value="XM_024853228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7G3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7G3"/>
    <dbReference type="GeneID" id="36560926"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475148"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="457" mass="52896" checksum="3572AB9112341A8D" modified="2018-02-28" version="1">MKLQPNGYKTWHQQYGPVICLKLAGYTVLILGTHDVVKDLLVKKARIYSARPSIGSAHYFTKGMVAGWLSYGPEWQKIHGIESVFFKRGLVQSYRLLQDLESKQLVYELLSGRDFVPLFQRFAKSTPFTILFGKRLATTDSPEVQELEDLVQSLVGEIKWVHLLGAIPLADRLPKPLKVWEKMGDRLHDRIFRIFEKYTTAAVKRAGWNWATELEHRMREQGLSFRQTCFLVYELQVAAFASTWIVLNRVIKAALLNPEKTRKVRQELDLVVGVDRLPRFEDVDRLPYTNAFLSEALRWRSFLPLGIPHSLAEDDEYKGCYIPKDTVVFPNQWALDHDEKVFHHPDEFLPERWIENPELPLTTFGFGKRICPGQHMARNTLFIAVVRCLWGYDLITTESPDDPYNSSRKAIDFSAPKGLSFVVRSEKHKETIEREWNMADKDMTPILSKIQEQAQCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7H7</accession>
    <name>A0A2I2G7H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704134.1">
        <property type="nucleotide sequence ID" value="XM_024847678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7H7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7H7"/>
    <dbReference type="GeneID" id="36555377"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425840"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="485" mass="52404" checksum="A7245DEB75206CE9" modified="2018-02-28" version="1">MSTNSSILGDSWVVEAAASPSPKKHPHPTNSQPSRATTDHTKKVPSPRETRASDHDSASVATASASGSFSGPELIMPSIYETPVDGSWVAPNVRSRQKHGQQGQRRRHQHQPPGTSPKDQKSPSHRDGARNQASEADQPRDPHHDKDPTKSAPSLLTRLEPSLRTLLNALLLASITHLLILPELITQHQSFFCTIPVLSSLYPTSCTAPSPFTVPSPQHLTTSPARTHEQKLALHATSLERLFTSTLTTLSPLPPLLKQSDARLRALHSDLSSAFPGSRNELALEFSGLWESWRSGSRKFDSLRADLRSAVDNLIATSISSSASSADGDGGHASNEKARGGNQEKAQARAAQISSAQLSRRAAYLDQLTSRMQGKAEALSTDLATVEDHLESIERIIMREHHPSSSSSSSHSTSDTIEKTEGEREGGGGWLSQVLGLGGARQERRTLGRSEREALVVAATGHRAVAEAVRNLSQRLEAVQRRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7K5</accession>
    <name>A0A2I2G7K5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_356507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704157.1">
        <property type="nucleotide sequence ID" value="XM_024844154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7K5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7K5"/>
    <dbReference type="GeneID" id="36551854"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356507"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="572" mass="63858" checksum="1A1ACE11B39A2859" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8T6</accession>
    <name>A0A2I2G8T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative phenol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_179692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704602.1">
        <property type="nucleotide sequence ID" value="XM_024842660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8T6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8T6"/>
    <dbReference type="GeneID" id="36550358"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_179692"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="336"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="546"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="679" mass="75074" checksum="93C565BE74BC9A28" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9I2</accession>
    <name>A0A2I2G9I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_426431</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704837.1">
        <property type="nucleotide sequence ID" value="XM_024847708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9I2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9I2"/>
    <dbReference type="GeneID" id="36555407"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426431"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="148"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB49535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="330" mass="34419" checksum="9111079F174F2389" modified="2018-02-28" version="1">MVKAAVLGASGGIGQPLSLLLKTCPLVDELALYDVVNTPGVAADLSHISSVAKISGFLPKDDGLKHALTGTDVVVIPAGIPRKPGMTRDDLFKVNAGIVRDLVKGIAEFAPKAFILIISNPVNSTVPIAAEVLKAAGVFDPQRLFGVTTLDVVRAETFTQEFSGQKNPSAVQIPVVGGHSGETIVPLFSKTAPSFQIPADKYDALVKRVQFGGDEVVKAKDGAGSATLSMAFAGFRFAESVIKAFKGEKGIVEPTFVYLPGVPGGEAIAKAAGVDFFSTHVELGSKGAEKAINVLEGVTEQEKKLLGACTEGLKGNIEKGINFIQNPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9W4</accession>
    <name>A0A2I2G9W4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_356343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704960.1">
        <property type="nucleotide sequence ID" value="XM_024844143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9W4"/>
    <dbReference type="GeneID" id="36551843"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356343"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000364">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="406" mass="45093" checksum="E5B4537111CD9350" modified="2018-02-28" version="1" fragment="single">VPSNMLLKNFKRPSVYLGILIVSWGIMMTLTGVVKNFAGLMVTRVLLGVFEAGFFPGAVYLCTFWYMPKDLSTRLACFYCASALSGAFSGLLAAGIAKMNGVGGYEGWRWIFILEGLATVVLGISSFFLLIDSPRLSGKWLDPEEIRFLELQAFIKEGGRFRDETQPAQKRVKWKDMKAVFLNWRMYILAYIMLCQSACTYGNKFTLPTITKSMGFSNTEAQLLTVPPYVAGAISAIGFSRLSDKFYWRMPFVVIPLSLLIIGYSILMSLDGQLGEHLGLSFFSVIIALMGLYPIHPATSSWTSNNLTPSNRRAIGLALNICIGNTGGIIGSYMFMDSEAPKYYTGFGLSLALGGSALLLALLLEASLWWENKKKSKISEEEVRAKYTEEQLLDMGDKSPLFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAK2</accession>
    <name>A0A2I2GAK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_435202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705194.1">
        <property type="nucleotide sequence ID" value="XM_024848886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAK2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAK2"/>
    <dbReference type="GeneID" id="36556585"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435202"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="54543" checksum="32D02C31F249EE47" modified="2018-02-28" version="1">MQPRRVVRFRHPVRYVVATLLLLAWLFYCLPRTERPQPIPAIPQTETHYGGCDIDLELLKSYEFGSSIEYARWEIAVVPSKNFKGFSDTLDVPLPTWQTVKLDDTEDARKLLPREQCAPTVMIEVPATQPRVDASHLVVGVATSLERLNDSLDAFAIWAGGTNCRIFALVDNVSSGAKNRVLQKASDLDIKLTIIASSEELLDRYFSLTRVLLRNRDEKTQWGVIIDDDTFFPSMANLVKRLATYDSSQPYYIGAPTENFAQMGIFNYMAYGGGGVFLSIPLLEEMDKVFDDCYEFKDMGDKRVARCIYHHTNTKLTWDHGLFQLDMRDDVSGFFEAGRPLPLSLHHWKSWFDVDVVAMHKVASICGDDCQLQRWRLTDDSFFVNGFSVIKYSQPMHDMLSMEQTFDDSDWARDEGFAFSLGPLRPKDYDKISFRMRSAIVDGDRVRQLYIDQPPPELNLKPRVLEVVWSKARGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBG1</accession>
    <name>A0A2I2GBG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_139042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705518.1">
        <property type="nucleotide sequence ID" value="XM_024842454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBG1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBG1"/>
    <dbReference type="GeneID" id="36550151"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_139042"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="295" mass="33238" checksum="E80EDFC0AB47DB1A" modified="2018-02-28" version="1">MPPVHLQIEDDDPPSFYLTVHSIVDPAIQPASSTSARDTALALDSLYLEYTRAHVDRDAEGFLWAFWDLMNVFARQVPHDSKQQDALIAIIHELVRLPPKPLKLDNGGEYQQWADLAFWGTAFPETWKSELGPYSDAQKKQRFLNLQAYAARIMTFAPIHMESNAIWTLEDAVEGAIIPVRGSPDLVSEDPLAIEDLPYKVALAAVWIIHAGHVLYGRDEEIYGTQGGPLYRLPKKEARVLRKKSIGTQGLCMERWLLWKKQFGVIRDCEDVDDETRGIAGKAVVAMERAENEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBI8</accession>
    <name>A0A2I2GBI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_473818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705552.1">
        <property type="nucleotide sequence ID" value="XM_024853082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBI8"/>
    <dbReference type="GeneID" id="36560780"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473818"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="136" mass="15282" checksum="40358D7BC65B89BF" modified="2018-02-28" version="1">MVKPPNLGPQSIQARISHLLNHWPSDPVRPASVSVQTYLRSRLPPQSSAQQQPPQSQSQSQPQSAPGGEISEASLNALSSLLENRYARRYPLPPKLRRPASNPDHYDNVIKEFAEAPSRDWLGRLGKRMRGLFRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBQ7</accession>
    <name>A0A2I2GBQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalase</fullName>
            <ecNumber evidence="6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_463522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705579.1">
        <property type="nucleotide sequence ID" value="XM_024852174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBQ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBQ7"/>
    <dbReference type="GeneID" id="36559872"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463522"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="8">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="731" mass="83855" checksum="5A7DC4D26C4F4AB2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC06</accession>
    <name>A0A2I2GC06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_354798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705697.1">
        <property type="nucleotide sequence ID" value="XM_024844058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC06"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC06"/>
    <dbReference type="GeneID" id="36551758"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354798"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="332" mass="36994" checksum="E4B7DEB16476F291" modified="2018-02-28" version="1">MTNNNNLKVVFGAMTFGKPDTLGARVHNTQDAAKILDIFQSHGHNEVDTARIYGAGSSEEILAAAEWQKRKLVMATKLYPSNAAVAESYTHQPADLRRGLLKSLSALSADKIDLFYLHGPDRNTPFVDTLREVNRLYQEGYFTRFGLSNFMAWEVAQICELCVANGWIKPTVYQGVYHVLQRSIEPELTSCLRKYGISLYAFQPLAGGFLTGRYARDQTEFEAGSRFDPKILQGAVHQRRYWNEAYFDGLEVISAAARKYGLTVGEVALRWLKHHSLLRGELGDAIIVGASSVLHLESNLNDLEKGSLPDEVAQAVGDAWACVKGVVPPYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCQ4</accession>
    <name>A0A2I2GCQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_355174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705952.1">
        <property type="nucleotide sequence ID" value="XM_024844078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCQ4"/>
    <dbReference type="GeneID" id="36551778"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355174"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="252"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB50650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="473" mass="51203" checksum="683853CD34E5F2F2" modified="2018-02-28" version="1">MNGIDLERTSSRQGNDPFQTPTSEQDETNAATNQADAFEDIPPNGGYGWVCTFCAFMITVHTWGINSAWGVILAYFLSNSTFPGAGHLDYAFIGGLSISQCLLIGPIVTKTYKAVGTTVTLLFGTALVFVSLFSASYSTKIWHLFLSQGVCFGFGMGFLYLTTMAILPPWFSTKRSLSIGLAASGSGIGGLVYNLASGHTIETMGWQMTYKILAFCALGSNLICSLLLRDRKQSRTAIAQRTFNHRDLSSFQVLLMIVWGVSTELGFIALIYSLPHYASSIGLNAQQGSVAGAILNLGLAIGRPLTGWVSDVFGRITVSMLMTAFCAVVCFAIWIPAQSYAPLLVFAILSGMVSGTFWGTITPVTAEVVGLSRLPSTFAMICLTLVIPTTVAEPVALSLVASSGYLNTQVYIACMFILGALSLWVLRSWKFYEIEKKAAKEQEGVYGSENALASFPSYFGWLQPRKLFLYGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCS6</accession>
    <name>A0A2I2GCS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_463790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705939.1">
        <property type="nucleotide sequence ID" value="XM_024852189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCS6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCS6"/>
    <dbReference type="GeneID" id="36559887"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463790"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="81"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="560"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="884"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1063" mass="115593" checksum="7BA13E4FCF9C663E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDX5</accession>
    <name>A0A2I2GDX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_159906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706390.1">
        <property type="nucleotide sequence ID" value="XM_024842561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDX5"/>
    <dbReference type="GeneID" id="36550258"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_159906"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="105"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="580" mass="64010" checksum="3DA0B0BCA422D611" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDY1</accession>
    <name>A0A2I2GDY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_160547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706418.1">
        <property type="nucleotide sequence ID" value="XM_024842567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDY1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDY1"/>
    <dbReference type="GeneID" id="36550264"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_160547"/>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="11906" checksum="0CF5C1515BA01A15" modified="2018-02-28" version="1">MAPASKSNESLMFLFICVSNLKDNAIDFNAVAAATNLKITAARMRYYRLKKQLEGELVDGKLDLTKAAADNSESTEAAAAPAMDSASTPAPAKKQRGAKRKKTVVKEENAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE14</accession>
    <name>A0A2I2GE14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_509178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706448.1">
        <property type="nucleotide sequence ID" value="XM_024854647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE14"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE14"/>
    <dbReference type="GeneID" id="36562353"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509178"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="310" mass="33378" checksum="38545C4DD4660E29" modified="2018-02-28" version="1">MTTAIKNVAIIGASGLLGSRISTALMSTGHHVAAIQRPSSEKQVPAGVQVIKADLNDEAALKQAFTGIDAVISAVGLPSFETEKVWIDAAFSAGVKRIIPSEFTTNMESPITIQLPVATEKVKVRQYLQSRITSPSAPTTWTSLNNGPFFDLTIKFGALGPNPLTQQAVFHNGGNNPIGPSTLSDIATAVARILDPAHLAETANQPVHIYSVAITERKLTALVSKITGVDFGSVEDGRIPDLNVSKLLEESNAQLAKGDFSVMMNYYYAMMYEEGYGGKDFEKLSWNERLGIRVMNDEELEEAVRGLIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEC3</accession>
    <name>A0A2I2GEC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative succinate:fumarate antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_436292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706525.1">
        <property type="nucleotide sequence ID" value="XM_024849127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEC3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEC3"/>
    <dbReference type="GeneID" id="36556826"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436292"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="322" mass="34720" checksum="B11C816BFCD054C9" modified="2018-02-28" version="1">MSAKGGNGKKTTSPAVNLIAGGGAGMMEALVCHPLDTIKVRMQLSRRARAPGMKPRGFVTTGVDIVKKETALGLYKGLGAVLGGIIPKMAIRFTSYEQYKQMLSDKETGAVTSKATFLAGLAAGVTEAVAVVNPMEVVKIRLQAQHHSLADPLDTPKYRSAPHALFTVIKEEGFSTLYRGVSLTALRQGTNQAANFTAYTELKAALQRYQPEYNNSQLPSYQTTLIGLISGAVGPFSNAPIDTIKTRLQKTRAEPGQSAVTRILVIGKDMFKQEGARAFYKGITPRVMRVAPGQAVTFTVYEYLKGKLEASKWSLVGGKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEN9</accession>
    <name>A0A2I2GEN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_330938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706613.1">
        <property type="nucleotide sequence ID" value="XM_024843365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEN9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEN9"/>
    <dbReference type="GeneID" id="36551065"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_330938"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="249" mass="28151" checksum="6CC76DE0A6BCDE20" modified="2018-02-28" version="1" fragment="single">DQVQKYVISVFAAIAWCNALELIVLCFSTFKRYRGCYFWSLLIASASLIPHCLGYIFYIFPLGISPYVSVTLILLSWCVMVTGHSLVLWSRLTLVLQSQKVLRGILTLIIVDAIILHIPTVVLMYGSITLEPFATGYNIMERIQLVWFCVQEVIISGTYVWETAKTLRIRPESRHHKILAQLLMTNVVILILDVAVVGIEYAGYYALQVMFKPVAYSIKFKLEYAILGRLIQIAKGGCSNDSPLSYTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GET6</accession>
    <name>A0A2I2GET6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_455556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706695.1">
        <property type="nucleotide sequence ID" value="XM_024851542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GET6"/>
    <dbReference type="GeneID" id="36559241"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455556"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="478" mass="53513" checksum="E8A8476A25485EAB" modified="2018-02-28" version="1">MVEERKRHCWECLRRSLVCDFTRPQCTRCSTAGVACPGYGATEPRRLKWLPPGKVTSRRQKKPVEHEVKGTGCSRGLARELPTDLHVFVQATEYYNACIYPDLRHIATLGRNTAIYPITPEIVQMAMARHPDHIRMVIVCMTLSHRMNRLRNEPGSQALVRDFFRYRGQLIRSLSDDIQAPERRTSDLVVAGMLTLLLVDAQQGASPHWRCHLDGVRKIIDLRGGICVMARSPGLRPLLLFVVFAAIMGDTSSPSSQLSLATSDMRALVVMITKHADHPFAFGTYPAALFREILNINYLRVKALEGASGDLIQSAFEILARIHSFCVAQWAQSISTNSDWELLGAIHQDAIAIYCIFSLQSLGVLPWNTQLGDLRTSHAHSLQQGLTAAVSSPCLKRFVGWDLVVLGVAAVKDTRLQAFLRHQLPCLSYSMGTHVPLLAKGLLEKFWALKSTHKTWDQCFDQPYTFAMHMSVDVSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEV3</accession>
    <name>A0A2I2GEV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_471336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706704.1">
        <property type="nucleotide sequence ID" value="XM_024852829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEV3"/>
    <dbReference type="GeneID" id="36560527"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471336"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="546" mass="57550" checksum="042DA7393FB29653" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF70</accession>
    <name>A0A2I2GF70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase with different specificitie</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_487573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706835.1">
        <property type="nucleotide sequence ID" value="XM_024853957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF70"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF70"/>
    <dbReference type="GeneID" id="36561658"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_487573"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="279" mass="29335" checksum="E878660F8E908922" modified="2018-02-28" version="1">MTTNPRTILITGCSAHGIGAALALNLARRGHFIFATARSPTKVPESLTSLENVQVLPLDVTDPITIADAVRAVTDHGRGLDILVNNAGAGYTMPILESDLDQAMNLYDTHVLGLLRLVQACSDLLVTSKGRIINVSSAAAAVNTPWLGVYSSSKAAVTQLSETLRLEMVPFGVSVVCIMAGNVTSAFHANEPGVVLSPTSRYAAARQAISNRATGRDGLEKCSADEFAASIVDEVLGTAGGVVWRGPYSATVRFLARWCPTVLLDCMVSNGQGLDLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG87</accession>
    <name>A0A2I2GG87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_349115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707200.1">
        <property type="nucleotide sequence ID" value="XM_024843719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG87"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG87"/>
    <dbReference type="GeneID" id="36551419"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349115"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB51898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="226" mass="24966" checksum="0FAAB441D67428C6" modified="2018-02-28" version="1">MAELASHGQPQRGALLVVEGLDRAGKSSQCEALRNSLQASGHPVKYVRFPDRTTPIGKMIDGYLRGQSQLDDHSIHLLFSANRWEAAKAIEEDIASGTTVIVDRYSYSGAVYSAAKGNPNLSLEWAWLPEIGLPRPDICLFLQISPEEAAKRGGFGVERYENEPMQKRVRELFGTIFGLQPSGDIRVIDAGRQFEEVSQDIQKAVAERIARLGDIGSLRKLERFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGW0</accession>
    <name>A0A2I2GGW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_433963</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707420.1">
        <property type="nucleotide sequence ID" value="XM_024848616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGW0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGW0"/>
    <dbReference type="GeneID" id="36556315"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433963"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="38"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB52118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="371" mass="39751" checksum="B33FF9DBA4FEA023" modified="2018-02-28" version="1">MFRQSVRRFGTTALRAAEGSTAYGVRVSQAQGVVHGLTEAIGNTPLIRLKRISEQTGCNVLGKAEFQNPGGSVKDRAALFVVKDAEEKGLLKPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPQNYNHQARRHAESLDNAVWTNQFDNTANRQAHIETTGPELWAQTGGQLDAFTCATGTGGTLAGITRYLKTVSDGRVKSFLADPPGSVLHSYIQSGGKLTDRSGGSITEGIGQGRVTDNLQPDIDLLDGSLNISDEKSIEMVYRCLDEEGLYLGASSALNVVAAKEVAEKLGKGNTVVTILCDGAYRYADRLFSNTWLQGKGLRTAIPKHLEKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGW4</accession>
    <name>A0A2I2GGW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zn-finger in Ran binding protein and others domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_96559</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707422.1">
        <property type="nucleotide sequence ID" value="XM_024855458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGW4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGW4"/>
    <dbReference type="GeneID" id="36563165"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_96559"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="253"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB52120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="610" mass="65369" checksum="1E64A7D661B2D770" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH50</accession>
    <name>A0A2I2GH50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707504.1">
        <property type="nucleotide sequence ID" value="XM_024852911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH50"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH50"/>
    <dbReference type="GeneID" id="36560609"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472107"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="40"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="438" mass="47026" checksum="836C5DE6D9F81973" modified="2018-02-28" version="1">MGSTAFQTPAVVKSAATPFFTPANNVGAAVHPDDPKTPTLFRPLQIRDVTVKNRIFVSPMCMYSADNDPSSPAVGAMTDFHIAHLGHFALKGAGLIFVEATAVTANGRISPYDVGLWQGVDSPQFHGLKRVVQLSHSQGAKIGVQLAHAGRKASTSPPWIAAEAGKVALKADEGVRGWPEDIVGPSGGAEQLWNPDGYWTPRALTTEEIKDVVRAFADSAKTAVEAGVDVLEIHAAHGYLIHSFLSPVSNKRSDEYGGSFENRTRLLREVATAIREVIPAGMPLFVRISATEWLEEQPVAAQTGSWDLESSVRLAALLPELGIDLVDVSSAGNHIDQKIHIHTNYQIDLAAHLRKAIRAAGASTLVGAVGFVTEAEQARDIVQEEAQGTQDIVSGPEPRADVVLLARQFLRTPDWVLKTAKALGVEVKVPVQYGRAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH89</accession>
    <name>A0A2I2GH89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HlyIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_453698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707551.1">
        <property type="nucleotide sequence ID" value="XM_024851382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH89"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH89"/>
    <dbReference type="GeneID" id="36559081"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453698"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF130">
        <property type="entry name" value="HAEMOLYSIN-III FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="326" mass="36812" checksum="F8315AEBA6673753" modified="2018-02-28" version="1">MATESLRLGLSLLLNPSFPKKQKQEPQQEQQQKLSKPVPPSKQLVFHISHLPKWMQLDPYIVHWYRPQLDSFEECFWSLFYLHNESINTWSHLLPGAYFVALLLMVEYWVSHLPFNVTLADVLAIQTYIAGTAGCLIFSAVFHATNAHSKEVATVFLKLDYLGIIMTISTTCTSMTYFGLYDSPFLQTTYISLTVFCAALVFWVTLDPRMDGVYAGHWRAAVFILLAASGLAPLCHVSLLEGVAGLEKFPLETLCVTCISYAVGTMVYVSRFPEKFWPQRFDLLGASHQVFHILVAFGQIVHLYGLRDSLIRCYLDNMLGNSVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI50</accession>
    <name>A0A2I2GI50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_423399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707846.1">
        <property type="nucleotide sequence ID" value="XM_024847505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI50"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI50"/>
    <dbReference type="GeneID" id="36555204"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423399"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="161"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB52544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="427" mass="48877" checksum="22AA92FEB6CA0EF6" modified="2018-02-28" version="1">MIPTRPFRRRTTFLAALLGLFLLYHFLTIRQELEPPHERRRVDCPPLPGMDDVLVVLKTGVTEATDKIPIHFQTTLRCVPHYVVFSDFEEEIGGIRIYDALQNMDPEVKRTVPDFDIYNRLQSQGRAGLASDDFADEANSAIGKPNNPGWKLDKWKFLPMVQESLKYKPDAKWYVFMEADTYFSWGTLMAWLSHFDASKPYYIGTETQIADVIFAHGGSGFVVSRPAMELVNDDYNTRSVLLNEYTDGHWAGDCVLGKVLADNGVSLHYSWPILQNSNVGELDEFTTGFYREPWCFPAAAFHHVGASDIQDLAQFEMHRWRLSQKTTLLHKDVFQELIYPELSNVRDNWDNLSEDEQLVVSSFHECKSICTNDPDCVQFVYRADKCFTGKTPRLGVRNPDARAGWIVRRVESMVDKAPSCSKPNWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIL2</accession>
    <name>A0A2I2GIL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_454011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708027.1">
        <property type="nucleotide sequence ID" value="XM_024851402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIL2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIL2"/>
    <dbReference type="GeneID" id="36559101"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454011"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="360" mass="39925" checksum="EED2AD1BBB78903E" modified="2018-02-28" version="1">MYVLDIAITFMVLTAVVVALRLFTRLYFIRTPGWDDLLIVLSLIADICFFAFLIEEVRYGLGKEAATLDPGRIQSQTKALYVTIPLYNLSLNLTKISMILLYRRLFPTRGYQIILLIALICVVLSGLWMILSAIFFCIPVHAFWDPAAPQNCLPKTAVWCLNAAIQIVSDLIIVILPMPVLTHLRLPKRQKLVLIVVFALGLFVCATSVVRLGAVIQLLNSNDASKANAPAALWSFIETNVAIISACLPPLRPLLAYFFPRLLPSRVRSSYAHREKTTCQTLDLSNPFNFTNTSYSASVTGNFSTHNAADGQESMHCPPECEGIHVVSELHLETASVDAVEDFHSYHLSPLSVTNSVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIR9</accession>
    <name>A0A2I2GIR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sucraseferredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_434489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708076.1">
        <property type="nucleotide sequence ID" value="XM_024848728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIR9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIR9"/>
    <dbReference type="GeneID" id="36556427"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434489"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF8">
        <property type="entry name" value="SUCRASE_FERREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="214" mass="24007" checksum="B4711D0B9FAB595A" modified="2018-02-28" version="1">MGYALVLALPPHPANENVQRIMVSASNLQEPEHDADSDTQTPQGSTVLLLPSFTFVDSVQSDDVKELVDCFIDVPQSSADGKPANSRLSYRPCQYDYVVLLCSHKRRDARCGITAPLIKRELERHLRPLGLYRDADDERPGGVGIFFVSHVGGHKFSANVLIYRKKEEQLIWLARIKPEHCEGVVKYTLLQGKVVHPESQLRGGFDKQRGLTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ49</accession>
    <name>A0A2I2GJ49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_444786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708205.1">
        <property type="nucleotide sequence ID" value="XM_024850657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GJ49"/>
    <dbReference type="GeneID" id="36558356"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444786"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000027">
        <property type="entry name" value="Protein FMP25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="repeat" description="RCC1" evidence="11">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="11">
        <location>
            <begin position="197"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="441"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="688"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="924"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1483"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1674"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB52903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1695" mass="187472" checksum="FCBD09571F83531B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJQ3</accession>
    <name>A0A2I2GJQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UDP-galf transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_123365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708413.1">
        <property type="nucleotide sequence ID" value="XM_024842369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJQ3"/>
    <dbReference type="GeneID" id="36550064"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_123365"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="41"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB53111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="404" mass="43793" checksum="D9E01369EF79D4A5" modified="2018-02-28" version="1">MSSEGEKARTSGEVSRPEPALPTVNPAAEKSEPPKATFHPAVYVSVWITLSSSVILFNKKILDNPEAQFRFPIFLTTWHLAFATLMTQILARTTNLLDGRKTVKMTGRVYLRAIVPIGLFFSLSLICGNVTYLYLSVAFIQMLKATTPVAVLLATWGMGMAPVNLKVLSNVAAIVVGVVIASFGEVRFVLIGFLFQLGGIVFEATRLVMVQRLLSSAEYKMDPLVSLYYFAPVCAVMNGLTALFIEVPNMTMNHIYTVGISTLLLNAIIAFLLNVSVVFLIGKTSSLVMTLCGVLKDILLVAASMAIWHTPVTFTQFFGYSIALLGLVYYKLGGDKIKDYTGQANRAWAEYGANHPAQRKSIIIGAIVLIFFLFIGSMGPSYAPESMDRMKGMLGGGAAPAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJV4</accession>
    <name>A0A2I2GJV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_473037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708463.1">
        <property type="nucleotide sequence ID" value="XM_024853004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJV4"/>
    <dbReference type="GeneID" id="36560702"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473037"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052567">
        <property type="entry name" value="OP_Dioxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202:SF1">
        <property type="entry name" value="HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="210" mass="23096" checksum="395A3D71A3BC7C69" modified="2018-02-28" version="1">MTTQSPQTKATHLIQSLEAHGQDDYIGESISQLEHCLQAAHQAQKSGARNDLILAALLHDIGQIIPLDARHETRMNIQNSNSNSSSKGENVGRVGHESIGGEYLRSLGFSRGVCRLVESHVAAKRYLTAVDHSYYESLSAASKKSLEFQGGPFTGGELAAFDQDPLRDEMVALRLWDDAAKVPGIEDSTPRAREYSMLIVEHLERQEIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK36</accession>
    <name>A0A2I2GK36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_473120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708550.1">
        <property type="nucleotide sequence ID" value="XM_024853013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK36"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK36"/>
    <dbReference type="GeneID" id="36560711"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473120"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014172601" evidence="4">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="228" mass="23708" checksum="8DD66CF89FE2C8CB" modified="2018-02-28" version="1">MLSKLSAALLVGTALATPADVQTRQNNCPSIHVFGARETTASPGFGTAGQVVNLVLNAHPGATSEAIDYPATGDNQYNTSVQKGVKAVTNQVTSFVNRCPNTKVVLVGYSQGAQIIDDAMCGGGDPNMGITDTAAPISSSVGSHVKAMIWMGNPRHTPGASYNKGTSNSPGFDPRPSGQTCSEYANLIQSYCDQADPYCSNGNDGSVHQSYGKVYGQAALQFVNSKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKY7</accession>
    <name>A0A2I2GKY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_435152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708848.1">
        <property type="nucleotide sequence ID" value="XM_024848872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKY7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKY7"/>
    <dbReference type="GeneID" id="36556571"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435152"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001190">
        <property type="entry name" value="Short-chain dehydrogenase/reductase SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="289" mass="30309" checksum="294EF400C2988A2B" modified="2018-02-28" version="1">MTEQKVPDPSILRPQRSLAGRVAIVTGAGAAGDGIGNGRAAAILLAEDDCAVVCVDIQLSLAEYTVQMITDERNGTAIAVQADVTVAADCQRVVQTAIDHFGRVDILFNCVGVSGASGTAESVDMEAWTQGLHLNISSMVMMVKYVVPEMRRNEATPGYRGSIVNMGSVAGLKGGTPHLLYPTSKGAIVNMTRAMAAHHARDGIRVNCVCPGMVYTPMMYAKGMSDEARQARKNRSLLKTEGNGWDVGAAVRFLASDQARWMTGVILPVDGGTTAAVGTELPASASVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLQ2</accession>
    <name>A0A2I2GLQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_396493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709105.1">
        <property type="nucleotide sequence ID" value="XM_024846121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLQ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLQ2"/>
    <dbReference type="GeneID" id="36553820"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396493"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="658" mass="72507" checksum="56D5FC96282D4060" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMI9</accession>
    <name>A0A2I2GMI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_469561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709398.1">
        <property type="nucleotide sequence ID" value="XM_024852646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMI9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMI9"/>
    <dbReference type="GeneID" id="36560344"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469561"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049373">
        <property type="entry name" value="TyrDC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21391">
        <property type="entry name" value="tyr_de_CO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="L-tyrosine decarboxylase C-terminal" evidence="4">
        <location>
            <begin position="588"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="979" mass="108784" checksum="32A3880778E2E3BC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN37</accession>
    <name>A0A2I2GN37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_397544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709585.1">
        <property type="nucleotide sequence ID" value="XM_024846183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN37"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN37"/>
    <dbReference type="GeneID" id="36553882"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397544"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="880"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="962"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="117"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="821"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="984" mass="107448" checksum="E35C8DE9DFB75F78" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNH9</accession>
    <name>A0A2I2GNH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_397914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709744.1">
        <property type="nucleotide sequence ID" value="XM_024846196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNH9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNH9"/>
    <dbReference type="GeneID" id="36553895"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397914"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="811" mass="91873" checksum="7911749285D38EED" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNW5</accession>
    <name>A0A2I2GNW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_505303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709861.1">
        <property type="nucleotide sequence ID" value="XM_024854277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNW5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNW5"/>
    <dbReference type="GeneID" id="36561983"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505303"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="306" mass="33088" checksum="EFC70B19FDBF0619" modified="2018-02-28" version="1">MRNDNQEIVSLRLEATKANSGIYGGAMHPALQEAAFEDKLETCKRLLDAGADPNAQGGRMGSPLHAAVWRGSVDLIWLLLNSGADSSIRDRSGRSALHLSLACRQHVLVLLESGANTNVVDRTGTMPLQSAARSHPRIVPQLLAAGAMAGVRDGCGRSVLHAAMGADKLQFQNVLDHLPESRRKDDLEAALPAVLKQPAEPGSVMLEQCKQIFHLILGEDNIDLSVPDPNGWTALELAECYGLNEEAYVLEQRGAQKGNLQQALRPSCWSSADRNPEVFLSEDKMEAWVTAISPSREVSMQLSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNW6</accession>
    <name>A0A2I2GNW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_452306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709868.1">
        <property type="nucleotide sequence ID" value="XM_024851254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNW6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNW6"/>
    <dbReference type="GeneID" id="36558953"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452306"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="556" mass="61759" checksum="73A0B2CEB863B3D0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ17</accession>
    <name>A0A2I2GQ17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_460944</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710277.1">
        <property type="nucleotide sequence ID" value="XM_024851989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ17"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ17"/>
    <dbReference type="GeneID" id="36559687"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460944"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB54975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="207" mass="22918" checksum="8EC8510FFC9589B1" modified="2018-02-28" version="1">MLSRVPRALRPSAIRSLRVGRIAAPAAVHPQPQSTPLRRGFHASPSIRKGLYPDSADPPAPNPQSSNVAGAATHVTEPSPLTDGQYHEYAEHYLNMLQTEVENTQEEGSEMEAEYSAGVLNIGVPGVGTYVLNKQPPNKQIWLSSPISGPKRYDWVVEGDQMHEKQESRPFVNGQWVYLRDGSNLTDLLNSELTLKIPKDVYSEEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ95</accession>
    <name>A0A2I2GQ95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alkyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_31186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710355.1">
        <property type="nucleotide sequence ID" value="XM_024843253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ95"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ95"/>
    <dbReference type="GeneID" id="36550953"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_31186"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8620" checksum="13EEB8823C8CD944" modified="2018-02-28" version="1">MSTSMHLSRLRKWVLASPPIEFALSRLRDLLVGALRQGPVPQHIAFVMDGNRRFARTHGIETVEGHNLGFEALARVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQB3</accession>
    <name>A0A2I2GQB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrase/ferredoxin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_421680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710367.1">
        <property type="nucleotide sequence ID" value="XM_024847382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQB3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQB3"/>
    <dbReference type="GeneID" id="36555081"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421680"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40386" checksum="7F2676F80840E9D1" modified="2018-02-28" version="1">MQALFRKGTSLFSPTPTDSSPEPGQTPEQSTPVTSTEDFSKAPSHDALFPKTDPAVDGEDCRHDCASCTVRYPAKFDVDQEDEVYGNVGGWATHLLVATGKTDWVRDVADESGSVMEAIEKGGIEPNNGKLKLSASNIPVPDEYHYHEPGTQPTTVLLLPSFTIVDHVTPALAPDLITHFVNPAPTTTTPLAGVEDVSSPTEKNQAAESEPAVPAPQTPLRSRASPHAAVILLCSQRTRDARCGQSAPLLKREFERHLRPLGLYRDLDDERPGGVGIYFISHVGGHKYAANVIVYRRRDFEWYKKQAKETGETAPQPDEGAAQGIWLARVRPEDCENVIRYTVLQGKVVKPKEQLRGGFDRERGLISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQC1</accession>
    <name>A0A2I2GQC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_432608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710372.1">
        <property type="nucleotide sequence ID" value="XM_024848298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQC1"/>
    <dbReference type="GeneID" id="36555997"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432608"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40052" checksum="F7797147CCE2EAC0" modified="2018-02-28" version="1">MPRKVIFLMGAPSVQSLRWDEHELLHAPIHPFHGASIGTEGAGSFDEAYPVKWRLLQEPLALPEASPDQDEPDPTRGARFFTIDELATPGDISTTTSDDSTLSKFYNHSFAIHETSEISAPGTSRDDSMRESGLWMDSTSTSIALSWDEETTKPSLPMQGNITDLQDVPSAAYLNGIVPQTMTVNLIVGIIAIRPPRRIVTRQWKRELDLVEVVVGDNTRSGFGVTFWLPRTGRDGGDENELRGRLATLRPRDIVLLGTVGLGAFRERVYGQSLRNGITRVELLHRQRVDATDAGGLYSARKLREAKPDDLPLAKVREVREWIRQFVGPEAAGGGTRGPKQRGPMEDPAKNPHPTILPPDTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQU4</accession>
    <name>A0A2I2GQU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_36447</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710559.1">
        <property type="nucleotide sequence ID" value="XM_024844640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQU4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQU4"/>
    <dbReference type="GeneID" id="36552340"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_36447"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="69"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="311"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB55257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="408" mass="47088" checksum="F43011C3FEECF871" modified="2018-02-28" version="1">MVAMASDSTKRKASEEALSPDSQQQSKKARTDSPEREPKTEDEPLGKPPLRIVPFPEKPAVLEERRGEIEFRVVNNDGSRDSFVVLTGLKCIFQKQLPKMPKDYIARLVYDRSHLSMAIVKHPLEVVGGITYRPFNSRRFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSPIMHFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTIMQCTMLPTIRYLEIGRMLLKQKEAVHAKIRAFSQSYKVHNPPKEWKNGPCKIDPLSIPAIRASGWSPDMDELARQPRHGPNYNQLLHLLNDMQNHSAAWPFTQPVNRDEVPDYYEVIKEPMDLSTMEEKHEKDMYPTPQEFIKDASLIFDNCRKYNNENTPYAKSANKLEKFMWQQIRNIPEWSHLADGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQV6</accession>
    <name>A0A2I2GQV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_399284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710567.1">
        <property type="nucleotide sequence ID" value="XM_024846275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQV6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQV6"/>
    <dbReference type="GeneID" id="36553974"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399284"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="442" mass="48704" checksum="0F8FCC8B86EFD08D" modified="2018-02-28" version="1">MARLLQSLRRVFGLTPARPPSKFARSIDIDFSRFCEGDCVVVHPTKNAQAKNVKLTKPLRKNQKTELPRGHLLHESVIGRKVRDRIQAHKGPDVRVTHPTLEEYVSMTPRLVTPIYGHDADLIVSLLDIHVTPPAEGDQLPPLEILESGTGHGSLTLHLSRAIQAANTAPPSIPPKSQIKHLEGRPLRSDEQNDQKGQKGQDGGKSDVVEPENSSPDPLQEQWDVWRSQRRAIIHTVDVSPTFSARAEKIVRGFRRGIYAGNVDFYVGHAENWIAEQIQQRTPKSLLSLTTPSVEPFLTHAILDMPSAHQRIPHVAPILRTDGILAVFMPSITQIGDCVDLIRKQNLPFTMDKVVELGAGISGGRQWDVRHAVKKSRADPSSWTKGADEAEGTKEASGEDADDSVSIPVEDAPRDDGVLVCRPKVGNRIVGGGFVGIWRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRV6</accession>
    <name>A0A2I2GRV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_506162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710906.1">
        <property type="nucleotide sequence ID" value="XM_024854368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRV6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRV6"/>
    <dbReference type="GeneID" id="36562074"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506162"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF6">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="24"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="38702" checksum="6E62394F7E57D06C" modified="2018-02-28" version="1">MVQYSKPAEPIPETQTVALVNELGGDIEFREDYPVPLPGQNEVLAKVLYTGVCHSDLHTKSGTAATADDKPRKHKLPHVGGHEGVGRIVALGPGCGSDLQVGTLVGIRFSSRICRRCDFCLAGMEQHCVKGTNHLTHEDGSFQEYIALDADYLTILPDDIDPKVMGPVLCAGVTAYKAVLNANIRAGNWLVVVGAGGGLGHLAVQYAKAQGALVIGVDAGDKREFVLFLGANEFIDFTSTDPTQRVHEITGLGAHAVVVTAGSAKAFAHACEMLRVGGTLSCVGIPPGRPALETPIATIVIKGLKITGSLVGSLKECMEAVDLVRHGLVNPVIKVRPFRDLPQVYEEMERGDIAGRIVLQVSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS23</accession>
    <name>A0A2I2GS23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_484703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710980.1">
        <property type="nucleotide sequence ID" value="XM_024853916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS23"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS23"/>
    <dbReference type="GeneID" id="36561614"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_484703"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="48"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="401"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="483" mass="52462" checksum="5E576DE33FD506DF" modified="2018-02-28" version="1" fragment="single">LEWTPCFQNYTCSRLEVPLDYGNYSNGKTNIAIIRIEAKNVTKDTQSLLINPGGPGASGVDTILEYGPSLGGIVNFQHHIVGFDPRGVGQSGPLVDCWPGHPERRAQFEKLYYTETSNATSSSLGNQYAAAEFYGKACSATVGGSQGNASYISTPAVARDMLTYAEAEAVASGKPKRDAKLMFYGLSYGTVLGATFAHMFPDRIERMILDGVVNAGDYYSMKWQANLYDTDDALQDFFDFCFKAGKKKCSFWDSSPRNIRKRLDNILADLKYNPTPIPSSEFCEIPILATYSNLKTLVMQAMYDPLNTFPALANVLAGLEQGNTTAYVGAVTSLLPFNPCNNGTAGSTQDSPVLIECVDGYSGHKFQNITEFGDWVEALNTESEFFGETLTTNSGSILDPKNTSFPIMFVTQQSDPATPKRNAYKMSSVFPGSVVLKQDAVGHTAFISASSCLLENVQAYLTGGHLPAANTTCKADQVPFQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSE3</accession>
    <name>A0A2I2GSE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_443498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711088.1">
        <property type="nucleotide sequence ID" value="XM_024850553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSE3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSE3"/>
    <dbReference type="GeneID" id="36558252"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443498"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014197805" evidence="5">
        <location>
            <begin position="18"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="523" mass="56755" checksum="C49982F20C3DED4C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQP0</accession>
    <name>A0A2I2FQP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_370581</name>
        <name evidence="8" type="ORF">P170DRAFT_370724</name>
        <name evidence="7" type="ORF">P170DRAFT_370833</name>
        <name evidence="6" type="ORF">P170DRAFT_370917</name>
        <name evidence="5" type="ORF">P170DRAFT_371076</name>
        <name evidence="4" type="ORF">P170DRAFT_371173</name>
        <name evidence="3" type="ORF">P170DRAFT_371288</name>
        <name evidence="2" type="ORF">P170DRAFT_371605</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000032">
        <property type="protein sequence ID" value="PLB42759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000022">
        <property type="protein sequence ID" value="PLB42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000020">
        <property type="protein sequence ID" value="PLB42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000018">
        <property type="protein sequence ID" value="PLB42931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB42997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370581"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370724"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370833"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370917"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371076"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371173"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371288"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371605"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB42931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB42977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB42997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="100" mass="11187" checksum="25250517E31163F4" modified="2018-02-28" version="1" fragment="single">STPHMSFHNVKLESSSTGSSFPADSAKPVPFAVVSLDNDEAFGYLKRVIVTPAVYPRLVEFLHFDIQSTGQKSHCVNTTFWPSQCYVLIRQSDSPCPYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR65</accession>
    <name>A0A2I2FR65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_394385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698398.1">
        <property type="nucleotide sequence ID" value="XM_024846058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR65"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR65"/>
    <dbReference type="GeneID" id="36553757"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394385"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="130"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB43096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="551" mass="60992" checksum="FB08B2DD7CEDCB58" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRJ0</accession>
    <name>A0A2I2FRJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_459729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698556.1">
        <property type="nucleotide sequence ID" value="XM_024851885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRJ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRJ0"/>
    <dbReference type="GeneID" id="36559583"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459729"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014187936" description="beta-N-acetylhexosaminidase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="10">
        <location>
            <begin position="69"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB43254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="705" mass="79107" checksum="8B27ECC81B9E004B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRK9</accession>
    <name>A0A2I2FRK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_514532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698572.1">
        <property type="nucleotide sequence ID" value="XM_024855214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRK9"/>
    <dbReference type="GeneID" id="36562920"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514532"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="684" mass="74854" checksum="ED9544F2DEE8AC23" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS44</accession>
    <name>A0A2I2FS44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_370289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698754.1">
        <property type="nucleotide sequence ID" value="XM_024844947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS44"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS44"/>
    <dbReference type="GeneID" id="36552647"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370289"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF152">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03410)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="272" mass="29626" checksum="3FC7347B771E70E7" modified="2018-02-28" version="1">MAPSKIDHPSVQGCLISFPAPHVLLLTLNRPKQRNCISLATSAEIQRLWEWFDTNPHLRVAIITGAGESFCSGADLKEWNELNERGITNEMTAPGLAGLPRRRGGKPIIAAVNGYCLGGGFEMVVNCDLVVASEQASFGLPEVQRGIAAVAGSLPRLVRVIGKQHATEMALSGLTFSASQLERWGLVSRVVASAQLLETAVEMATSIASNSPDSIRVTMEGLHYGWEIPSVEEASTKLVDRWYPKLIAGENFHEGVKAFVEKRKPQWRPCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS63</accession>
    <name>A0A2I2FS63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L30e-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_468321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698777.1">
        <property type="nucleotide sequence ID" value="XM_024852551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS63"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS63"/>
    <dbReference type="GeneID" id="36560249"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468321"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000027">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="98"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="232" mass="25001" checksum="9036E31110305366" modified="2018-02-28" version="1">MGKDKSEKKDKREKKEKRSEKDGVHKNGKKDRKSKDKTALADAVEQELTTKVLDGIDQAVEDAPVSGIVKAEMEVDVRPVGAVVPFASPLVEDKSAKKVLKSVKKAAVNKCLKRGVKEVVKALRKSPVPAPNAPISIPNGIVVLAADISPMDVISHIPVLCEDHGIPYVFVTSRAELGNSAATKRPTSVVMVVPKSASKGKKKDEDDDGEDFSSVYEELAKLAQKEAKRVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTQ7</accession>
    <name>A0A2I2FTQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transmembrane glyco protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_514312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699327.1">
        <property type="nucleotide sequence ID" value="XM_024855196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTQ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTQ7"/>
    <dbReference type="GeneID" id="36562902"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514312"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014164274" evidence="3">
        <location>
            <begin position="18"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB44025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="942" mass="102784" checksum="9A42AE55BB66EC2D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU80</accession>
    <name>A0A2I2FU80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_416668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699505.1">
        <property type="nucleotide sequence ID" value="XM_024847135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU80"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU80"/>
    <dbReference type="GeneID" id="36554834"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416668"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF8">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="9"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="402" mass="45610" checksum="154F6FF8718D2132" modified="2018-02-28" version="1">MTNSQNNVALVFGASGISGWAATKNLLTYPTPTTFSRVVGLTNRPKTVEESGLPQDPRLELYSGIDLRSSFENVVAQMQKIPNLDQITHIYYLAYSNATAYSQNVMDIRDINVHMTYNAVHASDQLCKSLKFLVLQTGTNNYGVAVFRYQDKIEINPPLKEDNPRIPSPWGDEIFYYRQVDLIKEASKGKQWKWCEVRPDQIVGHVPSPTSMTYVEPLALYLALYRYVNGPGSRVQFPGSHKSYTYTFTDSSQDIISKSEIYLSVVKPEQAHGEGFNIADTETPGPWSVKWPLLADHFGLEAAGPSDEGWVEIDKWWQEHAEDYKRMCAEYGLQYRVIGEAAWIFCKVGFTMLHRNRELSLQKIRGLGFTEEIPVGQSYIDTFEHMARERILPPSEALRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVF9</accession>
    <name>A0A2I2FVF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroorotase</fullName>
            <ecNumber evidence="4">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_430485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699914.1">
        <property type="nucleotide sequence ID" value="XM_024847961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVF9"/>
    <dbReference type="GeneID" id="36555660"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430485"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000041">
        <property type="entry name" value="Dihydroorotase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="356" mass="39299" checksum="FF6130C591993707" modified="2018-02-28" version="1">MPLSQLQGIKLPASADFHVHLRDGEMMELVTPTIRQGGVNTVFVMPNLVPPVTTVDRALDYKKRLQAIEPNVNYLMSLYLHDTVTPETIIEAKKRGVTGVKSYPAGVTTNSSSGVVDYTQFYPVFEEMERQDMVLNLHGEVPSTGDVTVLSAEERFLPTLLQLHERFPKLRIILEHCTTAAAVEAVKKCGPSVAATLTAHHLAIIVDHWAGDPFCFCKPVAKTPADRDALLRAAASGNPKFFFGSDSAPHPAASKRGGDKVAAGVFTQPYTTQLVIDAFEQAVQNGVLKEEDITPEIVEGFMSKFGRNFYGLGEEQKEFLILEKKEEKIADILQSGKVDVVPFRRNQQTWSVTWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWS5</accession>
    <name>A0A2I2FWS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_513151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700395.1">
        <property type="nucleotide sequence ID" value="XM_024855073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWS5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWS5"/>
    <dbReference type="GeneID" id="36562779"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513151"/>
    <dbReference type="OrthoDB" id="4510062at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="343" mass="38303" checksum="634D8AB602871806" modified="2018-02-28" version="1">MNLICPAGPYLLLILLILLILLILLILLILLILLILLTLPPDKRIMPSLTSPVESDVPTQADPPTATQLYNDNRKLPQDLPHLTDVPDRLLGLSNYDTWSFLIETALESADIPQLIQPSIAHPPPSDPSYPLWRRTSLLVKNWLVRQLEPRFLSRVIRFTIIHTNTTNPQPQPQTPTSTTTSAPLFADTMYTIIRRVALDQTPGLQALRCEITYLNCIFLDREQFASARDFIAAFRDAVHLTNRLHCTVTAYCAALLLLRALRPDLQGLVDVQIEEFDREDAPRGYSFGRFDSLCDFLSLRLLVEGGEGIPVDTVGVDDLDDLEGEGDGGGDTERDEDGDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWV0</accession>
    <name>A0A2I2FWV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_367053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700338.1">
        <property type="nucleotide sequence ID" value="XM_024844785.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FWV0"/>
    <dbReference type="GeneID" id="36552485"/>
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    <dbReference type="OrthoDB" id="329835at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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    <dbReference type="GO" id="GO:0031177">
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    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
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    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
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    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
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    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
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    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
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    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
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    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
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    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
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    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
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    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="63"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="945"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2426"/>
            <end position="2503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="945"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="977"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB45036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2510" mass="275533" checksum="58DDB7C7E4E26C7E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXF6</accession>
    <name>A0A2I2FXF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative high affinity zinc ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_367280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700616.1">
        <property type="nucleotide sequence ID" value="XM_024844802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXF6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXF6"/>
    <dbReference type="GeneID" id="36552502"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367280"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000006">
        <property type="term" value="F:high-affinity zinc transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="346" mass="37819" checksum="A95E458D66E973BD" modified="2018-02-28" version="1">MSSFNASHVDLNTASKEDVICYLSLSENDYNGHLGARISSIFVIFVTSTILTLFPVIAKRVPRWKIPYHVYLFARYFGTGVILATAFIHLLDPAYKRIGPKTCVGVSGRWGDYSWCAAIVLASVVTIFLLDLAAEVYVERKYGVEREDGTTNFFVTTNCHSNAGTRASKPDESQSEATSVASEQAFRQQFAAFLILEFGIIFHSVIIGLNLGVTGDEFATLYPVLVFHQAFEGLGIGARMSALHFGTRRWLPWALCLAYGLTTPVSIAIGLGVRNSYNPGSKTALIVQGVLNAVSAGILIYSSLVELLARDFLFDPERPKRRSHLGMMVGCTLLGAGIMALIGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYW0</accession>
    <name>A0A2I2FYW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_458066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701133.1">
        <property type="nucleotide sequence ID" value="XM_024851764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYW0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYW0"/>
    <dbReference type="GeneID" id="36559463"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458066"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="30"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="493" mass="53582" checksum="E8F8B8922705410F" modified="2018-02-28" version="1">MTPPNEAKAPETDNYEPPYCVLSERAKISTMLAASFAGMISPMSASIYYPALPTLANDMHVSNTLINLTVTTYMIFQGIAPSFTGSLSDVYGRRPAYIISFTTYVGANIGLALQNNYAALMVLRCLQACGSSGTIAIGSAIVADLSTRAERGKYIGYATIGMTLGPALGPVVGGLLSQFLGWRWIFWFLTILGGVLLVGFVVFVPETCRAVVGNGSVGAQRWNRTVWGILRRKGEGNERGIDYETVQKGGRRPNPLTSVRIATEKETGLILLYGALLYCGFMIVISTLSAQMESRFGFNAIQIGLCYLPFGVGTLTSRWTVGRALDWNFKREADRQGLSVAKNKQQDIREFDIEAARLKVTIPIVYAACLSIIAYGWVMDYQTSLAGPLVMLFFTGHLTTGAFTTLSTLVVDVHRQSPATAVAANNLVRCLLGAGAAAVGTPLIDRIGIGWTATFVAGVWAVFSPILWVVYRWGHAWREEMRVKGERDEGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYX1</accession>
    <name>A0A2I2FYX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_439543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701142.1">
        <property type="nucleotide sequence ID" value="XM_024849864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYX1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYX1"/>
    <dbReference type="GeneID" id="36557563"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439543"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="316" mass="34449" checksum="7001BEC021AB41F4" modified="2018-02-28" version="1">MTGLTPSQLASFQENGYLVIPSYLSPEEITSLLTETNHLLDTFDLTTHPLTQFTTGDDAKDNKPHVGDDYFLTSGDKVRFFFEPDAISPTPDPATGRPALLKPKQQAVNKIGHSLHSLSPPFEAVSLSAKNAAVARDLGFQDPRVLQSMVICKQPGIGGAVPPHRDSEFLYTSPPSAVGWWFALQDAGPGNATLGMFPGSQRGRAGGAVKRRFVRRADGLGTEFVSNEGASLPKGQEEAEVEGQAPKEEDVQVLDIKAGSLVLIHGNVLHQSERNTSQRSRFAYTFHVIEGAEGWEYDERNWLQPAEGGFSKLYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZA9</accession>
    <name>A0A2I2FZA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_414707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701266.1">
        <property type="nucleotide sequence ID" value="XM_024847026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZA9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZA9"/>
    <dbReference type="GeneID" id="36554725"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414707"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190669" description="Altered inheritance of mitochondria protein 6" evidence="2">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34465" checksum="6027392F3CE8BC15" modified="2018-02-28" version="1">MFPSRSLLVASLLNLVAAIPPELQNVLKNTHGGSEYGYPTDFTRGIMPIPVHSHNDYWRDIPFYTGLSRGCVSTEADVWLYNGTLYVGHDESSLTEERTFESLYVNPMVEVLERQNPKTPFVTSPTYNGVFDTDTSQTMYFFVDLKTSGPKTLEAVVAALQPLREKGYLTSLKGNKTIAHGPITVIGTGNTPLNLVGPVADRDIFFDAPLDALDRPEFAGVTSLISPIASTSFKRAVGKLNSSDDNAILSEKQLNSLRSQIQTAKKRGIGVRYWETPHYPIWTRNAVWRTLLQEGVALLNADDLDAVSNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZJ1</accession>
    <name>A0A2I2FZJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nonsense-mediated mRNA decay factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_259231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701352.1">
        <property type="nucleotide sequence ID" value="XM_024843067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZJ1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZJ1"/>
    <dbReference type="GeneID" id="36550766"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_259231"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000052">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="488"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="696"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="922"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1157" mass="131136" checksum="04C93C80A5080653" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G031</accession>
    <name>A0A2I2G031_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_512769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701526.1">
        <property type="nucleotide sequence ID" value="XM_024855021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G031"/>
    <dbReference type="GeneID" id="36562727"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512769"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="328" mass="38017" checksum="7052B2D0D4B02E38" modified="2018-02-28" version="1">MSSEGINKLPVELVMACAKCMDIFTLIRLSATCKGMYHILREEKRKLIKEYAYLPPKNPEAVYGSRTNSLRAFLAAGADPNGFNENTRLLSIAARYGNIDTVVLLMEFGAEFYLYDNRIPGYEWQYTPLLHALWAKVDRRVPCGNHGSTRETCSCENRLFALMRAGLKVTTYREFRLILSFDDHLKVLKYAVEHGSNFAILKPRLSYYSTALHIMVEAFMRYASSFYREENIKTIKWFALQYPNMLFVRDERNRTLLDVCLRRRRMPNLIRFLVKHDVQTGWAMYEEVGAACILCPEVVPLINKTTYLASRQAEGIDRLLPHDLIPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G075</accession>
    <name>A0A2I2G075_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_439891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701571.1">
        <property type="nucleotide sequence ID" value="XM_024849939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G075"/>
    <dbReference type="STRING" id="1392250.A0A2I2G075"/>
    <dbReference type="GeneID" id="36557638"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439891"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="314" mass="34036" checksum="74B1E737D314A23C" modified="2018-02-28" version="1">MLSFNPLTDIPDLSGKVCLVTGANSGLGEATVAALATHRPAKIYLAARSRSKAEGALERIRSTSSEASKTDISILDLDLASFESVKAAAARVNREVDRLDILQLNGGIAMLPHDVTKDGFELQFGTNYLGHALLTQLLMPILLTTARLPDADVRTVWMSSVGHKTFSSKEGIHFDQLKTPMESHSGPGLYAQAMLAKILFGRELARRYPQITSSSLHPGTVRSNVWGGAKNTNFLVKLLFAVVVPLTGVSNEEGAKTQLWCSFSKDVENGAYYEPIGKTGQDSPLSRDSELARKLWDWTEKTLEAHGAPGWPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0D6</accession>
    <name>A0A2I2G0D6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_427661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701635.1">
        <property type="nucleotide sequence ID" value="XM_024847788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0D6"/>
    <dbReference type="GeneID" id="36555487"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427661"/>
    <dbReference type="OrthoDB" id="10498306at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="332" mass="37903" checksum="E7F2BC39413A1366" modified="2018-02-28" version="1">MSGNIGHIIKAIPGLSDKIVDFLDRRLSRRPSKPIDRHSFQILIRQLSKTYLENTDPSMFLVGIGIRLAISRHLIASTRNFEDIYRVMEVLHHTIRGAEVSEFLVTGVLVKLAQYTVEQENYASKESMEFTKIHLAELCIAESAPVCTATEYICNYGERRLSRTSHEVACGLVLPRRVHATFFLHDLFFLLKEIRRAYLVFLEGEQSGLQTILLGFIQSFIEVFRTLIKEWSCPKLDPIQFGQEFELYSLLGVVTMLLDHLRNGNTDLLRCMDFAIQGGDNALCEIRKELRNSMRRGNLSREKLPYAAVAFGPSLDLLQEQLLRLQKKAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0I1</accession>
    <name>A0A2I2G0I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_361860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701675.1">
        <property type="nucleotide sequence ID" value="XM_024844482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0I1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0I1"/>
    <dbReference type="GeneID" id="36552182"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361860"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="217" mass="24744" checksum="3C661DAE59F68C31" modified="2018-02-28" version="1">MAVIKIDIISDAICPWCFIGYRNLQRAIQLYQKTYPGGSKDVFDITWKPYFIDQVPRGSELVQDRMLRRMSPEMVHGAQMRLKRVGTSAGIDFKFGGWIGSTRRAHQLLYLARKESSELQCQLSEKLFQYQFEKEADISRPEVLVEAAVQAGIPEERVKGWLASDEGMKETEEETKQIKESGIVGVPHFIIGETQHLQGAEDMEELFQAFIAAREGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Z0</accession>
    <name>A0A2I2G0Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_448398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701852.1">
        <property type="nucleotide sequence ID" value="XM_024850961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Z0"/>
    <dbReference type="GeneID" id="36558660"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448398"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF36">
        <property type="entry name" value="CHAIN OXIDOREDUCTASE (CSGA), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="262" mass="28510" checksum="4CBD569301FDB67D" modified="2018-02-28" version="1">MSTYLVTGSSRGLGFNIVNHLASRPASQVGTIFATSRQNNSAQLQELVEREKGRVVFVQLDAARKESVSQAVREVEMFLESEQQTQGKGKGLDVVINNAGIMPSTRGGIANMDDLNETFNTNVTSAHMVTSAFLPLLRKGERRVIANISTTVGSIAQAPKYKMSPTPAYKITKAALNMLTVQYAQELEKEGFTVLAISPGWLKTEMAGGDFADLPVSTGAEATMHIIDSATREMNGKFLNIKVPGWEENPGVNRYDGKEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G274</accession>
    <name>A0A2I2G274_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_477825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702273.1">
        <property type="nucleotide sequence ID" value="XM_024853505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G274"/>
    <dbReference type="STRING" id="1392250.A0A2I2G274"/>
    <dbReference type="GeneID" id="36561203"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477825"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="19092" checksum="58671AF69F333491" modified="2018-02-28" version="1">MSSIKIPIDAITSRFGDRFNSVRSQSIGTRFANLRPVSEFLDLKRLSKPANFGEVQSRVNYNLSYFSSNYAVVFVMLSIYSLLTNPVLLFVIIFVTGGLYGIGKLEGRDLELGIARFNTSQLYTGLLIVAVPLGIWASPISTVLWLIGATGVSVFGHAAFMDKPIENAFSEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G279</accession>
    <name>A0A2I2G279_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eisosome protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702269.1">
        <property type="nucleotide sequence ID" value="XM_024849658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G279"/>
    <dbReference type="STRING" id="1392250.A0A2I2G279"/>
    <dbReference type="GeneID" id="36557357"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438678"/>
    <dbReference type="OrthoDB" id="4070583at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024527">
        <property type="entry name" value="Eisosome1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298:SF1">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12757">
        <property type="entry name" value="Eisosome1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="83788" checksum="355B027440D3DE66" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3G3</accession>
    <name>A0A2I2G3G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_240652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702715.1">
        <property type="nucleotide sequence ID" value="XM_024842951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3G3"/>
    <dbReference type="GeneID" id="36550650"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_240652"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="153" mass="17526" checksum="0389194BCDA5B901" modified="2018-02-28" version="1">MNRTFIPVWVIVHVEHKWTSRLNMYVHILRALADDNFSIVTHHYSLGPELVNGGYVIPVQAQGHIPVYDQRPLIRRMAETWVHELYQHAREEEQRDSNSLPVEQSRSSETAQTGQGAQVAQPSQTYRPYRPPQPAQPSHAPPGGYRPYRPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4D3</accession>
    <name>A0A2I2G4D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_447645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703031.1">
        <property type="nucleotide sequence ID" value="XM_024850899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4D3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4D3"/>
    <dbReference type="GeneID" id="36558598"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447645"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="441" mass="48212" checksum="D1B6E4D9E71AD66E" modified="2018-02-28" version="1">MSPPKKPFQVAVVGGGIAGLTLAITLHHRGIPVTIYEQASAFGEVGAGVSFGPNAVEAMKVCHGGIHAAFEKVCTRNLWPSKQKVWFDYLDGHSKGESLRAHNASRQDIAFTISNCIGQTGVHRAHFLDELIKLIPGDIARFNKRLEQIGERGDGKLVMKFADGSEDETDLVIGCDGIKSRVRQILVGEDHPSANPSYTHKYAYRGLVPMDKAIEAIGEELASNACMHMGPGGHMLTFPVNQGKTLNIVAFHTSPEPWAEYPRLTRDGSREEVLRDFAGYGPNVINLLKLTDPKLSVWAIFDLGENPVSTFYKGRVCISGDAAHATSPHHGAGAGFCIEDTAVLAAMLEDDRVSSVQDLEAVLATFDSSRRERTQWLVQSSRFIGDCYEWRAEGVGSDFKKIEEAINYRNGIIANVDVNQLCAEAVKDLRDRLDRPVKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5B9</accession>
    <name>A0A2I2G5B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein 60S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_386292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703378.1">
        <property type="nucleotide sequence ID" value="XM_024845760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5B9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5B9"/>
    <dbReference type="GeneID" id="36553459"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_386292"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014132361" evidence="7">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="10855" checksum="8AC5B3CC77A1A593" modified="2018-02-28" version="1">MKHVAAFLLLTLAGNESPSAADVKGVLSSVGIDADEERLTKLISELEGKNLQELISEGTTKLASVPSGGAGAAAAAPAAAAGGDAPAEAPKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5P2</accession>
    <name>A0A2I2G5P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_465635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703501.1">
        <property type="nucleotide sequence ID" value="XM_024852334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5P2"/>
    <dbReference type="GeneID" id="36560032"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465635"/>
    <dbReference type="OrthoDB" id="4509088at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="548" mass="61950" checksum="5745C2FB25CAEFB3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5R6</accession>
    <name>A0A2I2G5R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_314344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703516.1">
        <property type="nucleotide sequence ID" value="XM_024843272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5R6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5R6"/>
    <dbReference type="GeneID" id="36550972"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_314344"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="99" mass="11144" checksum="B2208717B9B3B351" modified="2018-02-28" version="1" fragment="single">IMLLLRDGRVDINITDFQGQTALFYLVFNYNISFLTKLLQRQNININITDSGGQTVLFHAVKTGNKKTTDLLLKQPDIKANVLDKNYLTLLGHAASRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5R8</accession>
    <name>A0A2I2G5R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_323595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703485.1">
        <property type="nucleotide sequence ID" value="XM_024843330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5R8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5R8"/>
    <dbReference type="GeneID" id="36551030"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_323595"/>
    <dbReference type="OrthoDB" id="4509270at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="164" mass="18283" checksum="8FEFE7F37B255322" modified="2018-02-28" version="1" fragment="single">SALADCATTVRTVFSPTQQRLESTLELSRSLATVIEGDNSLARHFGVPLASDSMDRKIDSLFDKLQLMKDDEGKCTICWLDIVLAPSYNPARREDGCYYLQLDGRSGLIRVSESDHNFIESGLPQKLIDPRSYPRDVKSEEETMKLVGGLLLNLNKVASQSKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G776</accession>
    <name>A0A2I2G776_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metallophosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_446571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704032.1">
        <property type="nucleotide sequence ID" value="XM_024850809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G776"/>
    <dbReference type="GeneID" id="36558508"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446571"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="313" mass="34860" checksum="283149A43786B01F" modified="2018-02-28" version="1">MSTLSEPTIKTRFLVVSDTHGRENLPHEPADVAIHCGDLTNGSKLDEFKAAITLLKQLQAPLKLVIAGNHDFTLDIPIFQDKINEAWRLQSVDPLEIQQEYGYHGQVEDLFTEAQKFGIHFLREGIHRFTLENGASLTVYASPYTPSLEDSFWGFQYSPRQGHDFAIEQGVDIAITHGPPRGIFDYTHTGQRAGSTELFEAVARARPRMHCFGHIHGGWGAKLVGWRSKLSEKPSHLTDIDNGKSVVIQKLSNVKQAGKFQSCHQTSHCTGDATPLQPGAHTLFVNAAIEGSEDFPMQPAWIVDLDLLQSDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G788</accession>
    <name>A0A2I2G788_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_167564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704048.1">
        <property type="nucleotide sequence ID" value="XM_024842607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G788"/>
    <dbReference type="GeneID" id="36550305"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_167564"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="87" mass="9963" checksum="8D80D35B9400DBFE" modified="2018-02-28" version="1">MPHRKPTPGTLRPLTPRLHTKRLTSLISTQYIFLKPTFLKLFGWASLMRTLKLFQDGLVYSAGLYLLMHISLSPTSVSHPELRAIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7H6</accession>
    <name>A0A2I2G7H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704123.1">
        <property type="nucleotide sequence ID" value="XM_024847675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7H6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7H6"/>
    <dbReference type="GeneID" id="36555374"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425829"/>
    <dbReference type="OrthoDB" id="3527137at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="168" mass="19202" checksum="7274CBACD6A7EA0A" modified="2018-02-28" version="1">MAPKLPPQTVQTDASPVVHVRLVVHTLGPASPNTSDNHWSIYLIHPNGVSSTRINMRAEFDDPHEILEWTKHDYIHTTSAIACWDIPVSAGITVASIARLVYGLGRDRYTMSGGGSGCRWWVYTIVHDLARERYVNQDAPSQIWPHLLYLYHTQKERRQLHMIQGEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7N4</accession>
    <name>A0A2I2G7N4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_464471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704191.1">
        <property type="nucleotide sequence ID" value="XM_024852250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7N4"/>
    <dbReference type="GeneID" id="36559948"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464471"/>
    <dbReference type="OrthoDB" id="4479550at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1053" mass="114133" checksum="44DFCF015FD02587" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8G0</accession>
    <name>A0A2I2G8G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">P170DRAFT_475480</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704469.1">
        <property type="nucleotide sequence ID" value="XM_024853264.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G8G0"/>
    <dbReference type="GeneID" id="36560962"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475480"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1127"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1210"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1251"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1276"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1316"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1096"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1374"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1460"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1406"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="939"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="941"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1044"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1050"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1070"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1073"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1074"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1074"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PLB49167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1508" mass="168663" checksum="690E3BA4EA77DD5E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8J6</accession>
    <name>A0A2I2G8J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_436788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704465.1">
        <property type="nucleotide sequence ID" value="XM_024849223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8J6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8J6"/>
    <dbReference type="GeneID" id="36556922"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436788"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="395" mass="44375" checksum="A5D3D0DDE5DD2359" modified="2018-02-28" version="1">MALPFSQVPSGAKIPPSPFQVHVPDEQIEELQLLIKLSKIAPPTFESQQQDRKYGITTEWLTTAREAWKTFDWRAVEDHLNGFPQFKYSIDGLDIHLVALFSENPDAIPILLLHGWPGNFTEFLPLLSLVKEKYTPATLPYHFIVPSLPGYTFSSGPPVDRDFGTEDIAKVMNQVMANLGFESYVVQAGDIGSKVARILGVDYDACRAVHLNACFVEKPASVADSALSESEARNLQRAQWFALWGSGYFVEQGTRTSTIGNAIATNPVALLAWIGEKFLDWVDDRDPLPLESILKSATLYWLTGTLPRSIYTYREAFPPPPIKHAMDPRWYIQKPFGYSYFPRELIPAPKAWVATTGNLVFCNYHEKGGHFAALERPRDLLDDVLAFVEQVRGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8W7</accession>
    <name>A0A2I2G8W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative flavin-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_384050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704600.1">
        <property type="nucleotide sequence ID" value="XM_024845667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8W7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8W7"/>
    <dbReference type="GeneID" id="36553366"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384050"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="533" mass="60660" checksum="B2BFB2DA0FE1B279" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAU6</accession>
    <name>A0A2I2GAU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_355209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705304.1">
        <property type="nucleotide sequence ID" value="XM_024844080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAU6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAU6"/>
    <dbReference type="GeneID" id="36551780"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355209"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047580">
        <property type="term" value="F:4-hydroxyproline epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF5">
        <property type="entry name" value="BIFUNCTIONAL TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE_2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="188" mass="20098" checksum="037A972E52C1B65D" modified="2018-02-28" version="1" fragment="single">HGGTFYAIVDMGQTDLTLDPDEGQRIVEYGERIKRAVQATVHPVHPEKFGLHGVTNLIFTVPLTEGVNGTTAQNAVVVSPGRLDRSPCGTGACARMAQLHARNQLAVGEPFLHTSIIGTGYVGSITGTTRVGEYEAVRPRVKGSAWITGFQQVVVDPTDPFPEGFRVGDSWHVSKVPGPAGSRIDVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBH6</accession>
    <name>A0A2I2GBH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative beta-alanine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_473770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705499.1">
        <property type="nucleotide sequence ID" value="XM_024853078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBH6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBH6"/>
    <dbReference type="GeneID" id="36560776"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473770"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="455" mass="49448" checksum="73D46855F347CEF7" modified="2018-02-28" version="1">MLSTELSEAQVSALRANKDRLAKDLHHSCQWGPGVRWGEGPTDTGMQRLALSDEDKNVRDWFIETTKALKCNVTVDEMGNIFAVRPGRRKDVPPVFIGSHLDTQPTGGRYDGILGVLSGIETLKVIDEMGLETEGGVGVVNWTNEEGARFPISMVSSGVWAECIPLERAHGLKEVPTVASLPTASSAPESMKTALEKINYLGSVPCSYKETPMAAHFELHIEQGPHLVSADQRVGVVTAVQAYRWYRVNIIGRDTHTGTTAFQHRADALYAFARMMVRAREVASSHGCLASVGIVEAKPGSVNTVPGLVSFTLDIRGPETDLVEVVEAQLRKDFDAIAGDEGKGIGKPCRVDWTLDFDSPAVKFHPDCIDCVQQSAEAVVADAPEPKSLVRTIMSGAGHDSVFTSKRVPTSMIFVPCKDGLSHHPEEYCSADDCATGTSVILQAVIRYDRKRFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBS0</accession>
    <name>A0A2I2GBS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF159-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_405296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705632.1">
        <property type="nucleotide sequence ID" value="XM_024846577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBS0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBS0"/>
    <dbReference type="GeneID" id="36554276"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405296"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="404" mass="45925" checksum="C10294BC9F9E899A" modified="2018-02-28" version="1">MCGRYALNVRMRFIRNRMQEQGLQVDDAPPDDSIRETYNFAPGYNGAVYRAESPHDEHQPENEQEAPVHKPSYKLQSMKWGLVPSWTKRSPDYGSLMRTINCRDDSLIEDRGMWTSMKRKKRCIVICQGFYEWLKKGPGGKEKIPHYVKRKDGELMFFAGLWDCVSFEGSEEPLFTYTIITTSSNPYLKFLHERMPVILEPGSEAMKTWLDPSRTTWSKDLQSVLKPYEGELECYAVPKEVGKVGNNSPNFIVPVASKENKNNIANFFANAKEKKTEPAVVEKQAPTQEPKVEEDEDEKRSTKDNEWSEDNAPKPEPGVKREHDESGLGEGADTDEHQKKPKLEAHTPSPQKARGQLSPSPSQGQTMHSGRKTRSATHNQKTPKKADGKKASDGSQRITKFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBU1</accession>
    <name>A0A2I2GBU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_435548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705654.1">
        <property type="nucleotide sequence ID" value="XM_024848963.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GBU1"/>
    <dbReference type="GeneID" id="36556662"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435548"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="815"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1501" mass="165958" checksum="61F87BC50EB6C459" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC85</accession>
    <name>A0A2I2GC85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Yippee putative zinc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_322545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705800.1">
        <property type="nucleotide sequence ID" value="XM_024843324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC85"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC85"/>
    <dbReference type="GeneID" id="36551024"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_322545"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB50498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="169" mass="18262" checksum="A74B40B7881BF9DC" modified="2018-02-28" version="1" fragment="single">NGRADAKYLKGHVSYIRCSRCATDLCLTSQIISKGFTGRHGRAYLVSAEPEACAVSVNATSSPTVSLPNTIIQKPVPRQLVTGSHTVSDITCAFCGSVLGWKYVAAEEESQRYKVGKFILETRRIMTASSWESATYVDSPALPKSPGAADIEPKASEVPVEFDSQDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCL0</accession>
    <name>A0A2I2GCL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_435805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705921.1">
        <property type="nucleotide sequence ID" value="XM_024849026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCL0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCL0"/>
    <dbReference type="GeneID" id="36556725"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435805"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="287"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="731" mass="81751" checksum="A26EF7007A432D45" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCV6</accession>
    <name>A0A2I2GCV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_463845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706021.1">
        <property type="nucleotide sequence ID" value="XM_024852193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCV6"/>
    <dbReference type="GeneID" id="36559891"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463845"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="195" mass="21852" checksum="1C745AC71DBE5555" modified="2018-02-28" version="1">MASAPAVKVPVYSGNDLKSTTDDSLAPYLTTLPQPYTFTQDHSKTNVRFALGYTAVSIAAFTFYADRKLGWEATTSPWILAAVSSYFILNTILTYWVWGVESGEIFRGKRQSGETISIRSSNKKFSPLYKLHIQYTSPSNKVLQEKEIETPFTTWFAADGTFHPKPLQQWISSEIEVLKLAAKELEKKRAARAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDA7</accession>
    <name>A0A2I2GDA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secretory lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_474427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706180.1">
        <property type="nucleotide sequence ID" value="XM_024853139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDA7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDA7"/>
    <dbReference type="GeneID" id="36560837"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474427"/>
    <dbReference type="OrthoDB" id="5382058at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014140692" evidence="1">
        <location>
            <begin position="21"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="492" mass="54056" checksum="99440121187DFE1E" modified="2018-02-28" version="1">MATYFQYFVILLVGAQLATSQLITAAATQSTGWNSSFELSSDQIKSAELTSDMADIINTIINFDRSQLANGGAHEDDFYNVQGVPKNQWPTAPGKTIKLQEFTDPSPFSIPPKTAMSRIVYSTTDLNDTLIPASAYILWPYHARALRGRNHTSGSSAPVVLWTHGTSGWYANGAPSTHRGLFYADIVPFALAEAGYAVIAPDYAGLGVDTSWDETRIPHQYFVREAGAHDALNALRAVRESFPKRLSTDYVVMGHSQGGAVAWGLTEILGRNDSKFKDIAKGYLGAVFAAPPANALGPAFSGFLAWIAKDLDQIYPSFKLTEWFTPLGVKRIELLNQVAGSQMVTFAMFGPEEALLQPNWHETPYAHDFEKLANPGNLYFKGPVLLVHGTGDTTVPFNTTKSVALETCKQYAADLEFLAVPEGSHFSAMSAARQTWLRWVEDRFEHRPVAKRGCVESQLDSLLPVENYQGLGNSFLQWAGEPKWAYELPTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDB1</accession>
    <name>A0A2I2GDB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_155208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706152.1">
        <property type="nucleotide sequence ID" value="XM_024842541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDB1"/>
    <dbReference type="GeneID" id="36550238"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_155208"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="89" mass="10009" checksum="4F9DC75CA25BB8A2" modified="2018-02-28" version="1">MIRVFFDIMGGLGVLDDRFFGNILFLSILLDFSSIFVFCKVYILLKAVSKSTSPNTAVIEHTAFHTGRVLSREVIAMCQHSLNASFPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDC3</accession>
    <name>A0A2I2GDC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_508945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706143.1">
        <property type="nucleotide sequence ID" value="XM_024854627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDC3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDC3"/>
    <dbReference type="GeneID" id="36562333"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508945"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="66"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="233" mass="26960" checksum="3CA096E834004449" modified="2018-02-28" version="1">MEICACTCRSPHCERREQNSDYQVLGGRSETSVSPCQHKCWGSAMKPFVWYRGVSPGYCVGSRGCEWYTGAIPLLQTCRLIYTEAVSILYCDNIFRFNHVDTVISLSHTTLPSRFNLIRVLHLAHSFPFSMYGRKSRKVVAPYDAKTWEEVCQVLAKMSGLEELYMHLGEFDTTEIHEVLAPLHQIRQTKIFELFIGLRSDPEKLCTVKDRPFRLVGQQEWGMADQWEEWMCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDV2</accession>
    <name>A0A2I2GDV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_159566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706381.1">
        <property type="nucleotide sequence ID" value="XM_024842560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDV2"/>
    <dbReference type="GeneID" id="36550257"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_159566"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="102" mass="11542" checksum="201E18D779732157" modified="2018-02-28" version="1">MTLASPEIILLSLLHLSPASQCHRTSASLSFILFAFWLLLSRLSTVSRLGILLSFLSFFSLFPIDLLLPQKRSLSVILTDLPLIFNLCDSIRTPWILFLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDZ2</accession>
    <name>A0A2I2GDZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_436156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706384.1">
        <property type="nucleotide sequence ID" value="XM_024849098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDZ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDZ2"/>
    <dbReference type="GeneID" id="36556797"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436156"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="12652" checksum="EDD21A9BC15B9259" modified="2018-02-28" version="1">MSAQAYYELYRGSSLGLSLTDTLDDLINEGRIEPQLAMKILSTFDRIITEVLADKVRARLTFKGHLDTYRFCDEVWTFLIKDVNFKLDNQTTVSANKVKIVSCNSKRPGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE42</accession>
    <name>A0A2I2GE42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative translocon-associated protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_509163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706432.1">
        <property type="nucleotide sequence ID" value="XM_024854646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE42"/>
    <dbReference type="GeneID" id="36562352"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509163"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014135135" evidence="11">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="261" mass="28097" checksum="A87F89BCF0B73518" modified="2018-02-28" version="1">MARFGLLSLALFSVQALIGGGLAADPAEKVEENAESPKLAVSAQASFPASEIFGVKLVNGLPTQALITFTNDEPAPVTVNFVGGTLSTLDEDESQVVRNLTATAYGVEIAAGEKESLSYSFSTEMHPQDLRLSLASILSDSEGRYFTVYAHNGTVSVVEPETSIFDPQIIFLYFFLLACFVGVVYFFYTVWVAPYFPQKRKSGKGPEKASASKKAEATVEAPSSPAVSSATTYNADWIPAHHINRPEARKVKGSTRSKNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEI4</accession>
    <name>A0A2I2GEI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_436341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706582.1">
        <property type="nucleotide sequence ID" value="XM_024849137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEI4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEI4"/>
    <dbReference type="GeneID" id="36556836"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436341"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014154587" evidence="1">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="262" mass="28218" checksum="CB9C7DE73884A3AA" modified="2018-02-28" version="1">MHLGSLITFSSLVLPSFSSPLPAPASPLSKPPFFLLAGDSTTATQATNGGGWGDGFLNTTLHRGANGRNYGHNGATTVSFRAGGDWDAVLQEVRERRVTYAPYVTIQFGHNDQKPAKNISIAEYTANLEGFVEEVRGVGGVPILVTPLSRRSFNETTGEVVRNLENERKATIQAARRSRASVVDLNLRSTEYLDAIGEEKAHSYNLSPDDNTHLNVPGSQVFGGLVASLIDGVRPELKGFVAVDGALETALDEGEYYWPDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF32</accession>
    <name>A0A2I2GF32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_453206</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706801.1">
        <property type="nucleotide sequence ID" value="XM_024851346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF32"/>
    <dbReference type="GeneID" id="36559045"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453206"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000006">
        <property type="entry name" value="2-oxoglutarate-Fe(II) type oxidoreductase hxnY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="381"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="859" mass="94709" checksum="7D6AE3470D4139FE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF63</accession>
    <name>A0A2I2GF63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_376039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706821.1">
        <property type="nucleotide sequence ID" value="XM_024845343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF63"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF63"/>
    <dbReference type="GeneID" id="36553043"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376039"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190675" description="AAA+ ATPase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="137"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="689"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="962" mass="107736" checksum="16FA333A3B855874" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFA0</accession>
    <name>A0A2I2GFA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucanase</fullName>
            <ecNumber evidence="10">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_348549</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706865.1">
        <property type="nucleotide sequence ID" value="XM_024843685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFA0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFA0"/>
    <dbReference type="GeneID" id="36551385"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348549"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014150374" description="Glucanase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="427" mass="45913" checksum="51B2BE0E55BD952A" modified="2018-02-28" version="1">MARTFALLALLPLITAQQIGTIPEVHPQLTTYHCTRHNGCVQQNTSLVLDAATHPIHKAGTNTSCTNASGLDPSICPDKETCSQNCVVEGITDYSNYGVQTSGSRMTLRQYLRDATTNQTRSVSPRVYLLAEDGESYHTPSLLNQEFAFEVDVSTLVCGMNGALYFSDMLPSGGRSALNPAGATYGTGYCDAQCYSTPWINGEANTADRGSCCNEMDIWEANARATGFTPHSCNTTRLYECTGAECGDSGVCDKPGCGFNPYALGAKSFYGYGPDTTVDTTRPFTVVTQFLTAANTSTSPLSEIRRLYIQSGRVIQNAVVHVNDREIDSLTQPFCSETASSFTRLGGMKQMGEALARGMTLAFSIWNDSGSFMQWLDGGDAGPCNATEGDPKLIEKLYPDTRVTFANVRWGDIGATFGGRTGLGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFB0</accession>
    <name>A0A2I2GFB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_349603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706867.1">
        <property type="nucleotide sequence ID" value="XM_024843749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFB0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFB0"/>
    <dbReference type="GeneID" id="36551449"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349603"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="477" mass="51798" checksum="C4CA79C061C2F22A" modified="2018-02-28" version="1" fragment="single">GAFLASADESLMLSTFSSVASGFNLLSEGSWLLVAYNLGYCMALPVYGRLSSVYSRKNILLFSYGLFMLASLACGASPSFYWLVLARAVAGLSGAGMVLLVSIVISDVMPPEDVAVYRSYENLTCMVGRSFGAPIGGFLLDTVGWRWSFYGQIPLALICTLFVALTLPRSMGKAASSQKIPASDDGIWQIDFAGLFSLACTILSLLFLLQTAGAQTVDHPEWVHIAMLVFVVSLVAFIAIECLWAREPLIPMDLMGKAFGVYCLGQVLLVMGRSGVLSNLAPYFIRVENTSDLEAASLTVFWLLGLSVGGIVSGHIIKRTQRYKNMTLIALGFCIMVNLAISVQWRDGCTIWEALILFPLGATLGIFYSTQFIGMSASLPKNRQAACFGAFFLCQQLGFITGPAAGLALVQAIFDHSLENNLLDSPRKELVIGKILDDSRFSKRLPEPMQEVVRASYLYAFQFAPCKLSTLGSWMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFD2</accession>
    <name>A0A2I2GFD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_376156</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706891.1">
        <property type="nucleotide sequence ID" value="XM_024845353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFD2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFD2"/>
    <dbReference type="GeneID" id="36553053"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376156"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="89" mass="10390" checksum="A33DCD47FF2F97AD" modified="2018-02-28" version="1">MKVTIKEWNAVATWRWDMPDDEVCGICRVQFDGTCPTCKFPGDDCSLLLGKCGHSFHMHCLMTWIQQESSKGLCPMCRQKFEWKQNEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG13</accession>
    <name>A0A2I2GG13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_348341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707125.1">
        <property type="nucleotide sequence ID" value="XM_024843671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG13"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG13"/>
    <dbReference type="GeneID" id="36551371"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348341"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37499" checksum="D574FA7ABD733195" modified="2018-02-28" version="1">MSNPPERPWTEEEKYTLLTEILKKAGFPSSHLVKMIRDFNISPNWADIPLPPGRSMNSCQMAFVNMVQHVQASVNPGMGPFPLPRHEASLPPAPSFEGGNVRKRPLFPADKPMRAPRAIQPRPAGASTASLSSESGASALVSPGAESVAARGEPPRKRGRPSKAESERRKAAAEARGETYPPPRRSGSSKIKIPSAPTSPAGVEPFAATFTPQATASRPPHIPQPNLRYAPPIARTMGFIGPGDDDRLRDPANRDIDPALRELPRPTEMRQTLPSPQALQLGHRETMARVNPVERPFERPHPDRVPFADRRALLHPPSRHHDEPSVSSPEMSMRPSSEKRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG93</accession>
    <name>A0A2I2GG93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_433809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707210.1">
        <property type="nucleotide sequence ID" value="XM_024848579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG93"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG93"/>
    <dbReference type="GeneID" id="36556278"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433809"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.20:FF:000005">
        <property type="entry name" value="NADH pyrophosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="250"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB51908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="415" mass="45549" checksum="6B9DFE1B7EF16EC0" modified="2018-02-28" version="1">MSDHSQLPTPAHTQAESMLSRRFGKETVNYFSSSPLNRLSFLRGDHPFLSAALKHPSTRFIVLKELAPLTKSPAELYHAKHEEVQKLVPASIYDKSEEDIIKEHDSRKTSPHLIFLGLDESSKQGGFAWKIYTGTPYFALDATPRGSEEQQSNAKDILGALEAKGLSFLQARVAMSFSADEAAIYAQARALMDWNTRNTFCGTCGNPTISVNSGTKRACPPTDLARVAEGKPADRPACSTRTTISNLSFPRTDPTIIVAVVSTDGKRILLGRSKRFPPNWYSTLAGFIEPAESVEDAVRREVWEEAGVTLSRVVIHSTQPWPYPANLMIGAIAQVSDPAHETINLEHDPELEDAKWFDVQEVEEALRIGTSPLGEKAGSEYKEGGLRLPPPTAIANQLIRAAIGIDLLGDKNSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGF2</accession>
    <name>A0A2I2GGF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707219.1">
        <property type="nucleotide sequence ID" value="XM_024852876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGF2"/>
    <dbReference type="GeneID" id="36560574"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471843"/>
    <dbReference type="OrthoDB" id="4498167at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="127" mass="13608" checksum="183846C81C55E4BD" modified="2018-02-28" version="1">MSEFMDQSTKGTQPMFPTGSEDYRPSAEPHINTSRALDPHTSIEDYSRVMLQYTQNRMSGFARLDDDKGSSGSRSGSDTGNESGDSASGVLARQADGRNSTARSSSASLSNPPLSNGEKLNSIKDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGI8</accession>
    <name>A0A2I2GGI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_444054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707249.1">
        <property type="nucleotide sequence ID" value="XM_024850603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGI8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGI8"/>
    <dbReference type="GeneID" id="36558302"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444054"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="969" mass="108352" checksum="1C7AFB04429A505D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGR2</accession>
    <name>A0A2I2GGR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707377.1">
        <property type="nucleotide sequence ID" value="XM_024848610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGR2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGR2"/>
    <dbReference type="GeneID" id="36556309"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433943"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="60"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="334" mass="37607" checksum="5F059B2E2B38E6D1" modified="2018-02-28" version="1">MAPLTATEVVNHPAYKAVGYNLTPTVSGTHPVAHNRRGGPFNLYYEIHGTGPIKTVWIMGLNASHQDWRRQTRYFGHEHADKYSCLVFDNRGVGQSDKNVTFYSTSEMARDAVDLVASLGWIDLSAAPARAIHVIGASMGGMIAQELAMLIPDRLASLSLCCTAPRLVRTAPFMENLYQRASMFIPRHIDVELDQLAHSIFADAFLTQPDEEHEDARLNFPTKRDRFAASALKKREDTEGFTKKGFMLQIVACFFHQKTAKQLAELAERVGRERISLQHGTEDRMLTLKHGEILKEELGEGVVWKAYEGTGHMLGWERETELNGFLDEFIQTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGW8</accession>
    <name>A0A2I2GGW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_422989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707379.1">
        <property type="nucleotide sequence ID" value="XM_024847478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGW8"/>
    <dbReference type="GeneID" id="36555177"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422989"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="198" mass="22458" checksum="FF74CB61C6A9D0F8" modified="2018-02-28" version="1">MEWKHQKGTGYSHEQREKRQRTRNKDTLERLHNSSSEFNLILKPLSLCSIRLQVDTDGRAPIIPAEAVRVASGFWKPDMSRNRGERTDGTPRPSGQYKLPMNLFGCLTGRSILHVDCRHLVQVRGLVNGLTWRNKLSGILSTRVLGHADDPCLQDWEIYTPMEFPKPPNQLAPVGFLHTYSIASPRIISKDATALFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGX8</accession>
    <name>A0A2I2GGX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_422996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707389.1">
        <property type="nucleotide sequence ID" value="XM_024847479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGX8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGX8"/>
    <dbReference type="GeneID" id="36555178"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422996"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="208" mass="23584" checksum="8664B327C8B67F98" modified="2018-02-28" version="1">MRTNCLKHAIILARDQKAISHPHCLYLFQSLGHGMPTESTFPISQFARRFWAYADLSFSVPSPFLLGGSIGCGATCVQVTLEAAWENGHPSHPHVTMMIYRRFNGPEGSMLHSELVPIISAMRSRAYQPKVKEHEMDDLFEGKPFADKPRVFPKEKRFPVLLLSFVGPQHARIFYAYVEDGNKLIIRQRLADAPVELFARFPVGRPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHQ9</accession>
    <name>A0A2I2GHQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">P170DRAFT_349531</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707723.1">
        <property type="nucleotide sequence ID" value="XM_024843743.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GHQ9"/>
    <dbReference type="GeneID" id="36551443"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349531"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
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    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
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        <location>
            <begin position="677"/>
            <end position="881"/>
        </location>
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            <begin position="947"/>
            <end position="1394"/>
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            <begin position="1442"/>
            <end position="1514"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PLB52421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1545" mass="176776" checksum="44DEBC7DF51C2FE7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHY1</accession>
    <name>A0A2I2GHY1_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_472376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="PLB52486.1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF81">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="588" mass="65166" checksum="F8E7AE2C9DA3E97C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIK0</accession>
    <name>A0A2I2GIK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708017.1">
        <property type="nucleotide sequence ID" value="XM_024852966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIK0"/>
    <dbReference type="GeneID" id="36560664"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472605"/>
    <dbReference type="OrthoDB" id="2537141at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="395" mass="45289" checksum="B8F5BDCA7B3866F2" modified="2018-02-28" version="1">MAEVPEKPVTNHTSHNLSTESRFGEPVYFSSANNRIGNEQSEESPEVSLETYTKRLLYFDFSSWEMSEVVSEVGPTRKYWTLEDLKDLLEERIKSWHLNSQEQPNCKHSRSIKSNTITLQQASKVETQSRNDRIEVIQTVEPSYEDMAFTAPEIFHKIDKDGSEKLEQECPCWSPRGDEECHDFMDFDQELTASANFAELINHEHPAIYAGDSCQNYDTEMDWKYDEPLVLNTTENDLIVDKDEDLDLHALDAAYDMIVDSDKGSIDEAPDDGRIGLTEDALMRENEAVDLIQQGHQPWGISDKGCSLFPTFFSGAAQYKSAQPNFGRQESNEETCARGNGQQPCTRNPQEMEYYTRQFPAWRQGRSGQQTADVLGPEEEFLHGLKGFWRQNKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJB2</accession>
    <name>A0A2I2GJB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708273.1">
        <property type="nucleotide sequence ID" value="XM_024848770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJB2"/>
    <dbReference type="GeneID" id="36556469"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434694"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="74" mass="8870" checksum="C2F5B6AB7387AE9C" modified="2018-02-28" version="1">MFFEQTDRERMRSEGLECREETKNATRESERERERAREKETREKRGRERKREKGKGTCRCANPPPAPLFAGIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJG1</accession>
    <name>A0A2I2GJG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_120976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708318.1">
        <property type="nucleotide sequence ID" value="XM_024842359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJG1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJG1"/>
    <dbReference type="GeneID" id="36550054"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_120976"/>
    <dbReference type="OrthoDB" id="2364732at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="592" mass="66652" checksum="613BD65C061CFD61" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJL2</accession>
    <name>A0A2I2GJL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_379453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708368.1">
        <property type="nucleotide sequence ID" value="XM_024845486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJL2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJL2"/>
    <dbReference type="GeneID" id="36553185"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379453"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF10">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="517" mass="55539" checksum="F613E665E8FF5EB3" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK55</accession>
    <name>A0A2I2GK55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_463023</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708570.1">
        <property type="nucleotide sequence ID" value="XM_024852130.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GK55"/>
    <dbReference type="GeneID" id="36559828"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463023"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF397">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="179"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1311"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1441"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1325"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="159"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB53268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1711" mass="188069" checksum="38B8C77CEE16EFC5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKA8</accession>
    <name>A0A2I2GKA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_404297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708591.1">
        <property type="nucleotide sequence ID" value="XM_024846518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKA8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKA8"/>
    <dbReference type="GeneID" id="36554217"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404297"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="492" mass="55991" checksum="0FE8A9D7004B50F6" modified="2018-02-28" version="1">METVSYLTTKELSMEMRYFPALLFQVIALSLQFVPTGWDVWSRLPAAGILASEQYSDLGDELLSLLGRPGLALVAVQADFLRSSWLKNCGRGIESWHTVGSAIRQAQELRLHQQKEIHQTHHLNVGKTLSLFWYEENKKRLWINLFVWDSFMAMILGRPRMINLDDCDTKPPMNCNIPRDPSTAIPMTVRPEDSHSPVMISAPLFRYSLACKVHKMKATRADSPRLTNYTIVQTLHEEIMLLMDELPPFLRLKNADTTWDLEHQYLPQLRQELQVMLNLFVMALHRPHIISNEESRRAALQAALQTLDCQRCFFAQAEKDQYHLFGMAFYTVDASFLVSIIAILFPPSSHKAKQRVDQSLQHAIEDLSRMQSSNPIARSGLGILRHCYQKVKITFEPPNSASESRTVSHGTPGDELNTLINDVGLQSFDSCPNLESDTSQVNTASWHGSPDLPSLSIPDVFNQGYWLNQLNMIYPSISDEDTGLLWESLYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKJ3</accession>
    <name>A0A2I2GKJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pal1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_129374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708698.1">
        <property type="nucleotide sequence ID" value="XM_024842401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKJ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKJ3"/>
    <dbReference type="GeneID" id="36550096"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_129374"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="414" mass="46348" checksum="348FC29B8D7F70A7" modified="2018-02-28" version="1">MTFPTERQDVTGNTRDLFENLSLGSAPQPTGYRPAPPPPTKPQVNGASSRPPPSSRERPERRQKDPLDIFADPPRPSKPSGSSGPRPRDRERRPRRNSESSIMDRAPKLIDVDDEKRRRERRRREKERSERSDSKKDPKSRSKKQNYQLDIIDKLDVTSIYGTGMFHHDGPFDACNPNRNRKGLRTAPMQAFPKDSTNMALGGAGPLNQNIDLNLFHGRTEEGYNDFAASGADRRTEGVSFDPKSRIEPVHGAQTMGLGTSTFLDGAPASRSAMQRRASENENQGGMGGGGGLQRKKSLAQRLRGMNRAPEPSYTAPAANSGTIRANEKNPFFQDYDDAWDKKGARIDESREIGRTRSSSSPKQSPGLERWHTNERTNSGFDERQNQNQNNGGGFLNRMKSLRKPRPERRVSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL20</accession>
    <name>A0A2I2GL20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_508168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708885.1">
        <property type="nucleotide sequence ID" value="XM_024854538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL20"/>
    <dbReference type="GeneID" id="36562244"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508168"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="217"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="386" mass="43715" checksum="B06773DA475095FF" modified="2018-02-28" version="1">MESIVRQIKELYAESDPEGRERIHRDIRRLQGSLYSEMEFMIDLAANGPVKYSMTKIGVDLHIFEALHEGDEPLTGSKLAERTAAAPELIRRILRTQAALGLIDQVGADSFQSNRLTGFLANSALTSLLLFQQPVFGPAYQALPDFLRARNYQQVVSEDDTAFQVGHRTNLTFPEFLKQHPEHLHNLHKSMQLSYGNQWIDRFPVEKELSQFVTDSNERPVLVDIGGAHGQQARVFRQRFPSVPGRIIVQDRAEVIENVADIDGVEFMVHDFLQPQPIRGAKFYYLRFVLHDWPDEMCVKILQSIIPAMAPESRIILDELIPSDLGMSHWAAVMDTAMLATSGGSERSRGDWVVLLDRAGLQMLDLLEYDPQNLSVIVAVPKEQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLI2</accession>
    <name>A0A2I2GLI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_460099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709031.1">
        <property type="nucleotide sequence ID" value="XM_024851909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLI2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLI2"/>
    <dbReference type="GeneID" id="36559607"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460099"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="70"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="445" mass="50248" checksum="797DE83E6771F071" modified="2018-02-28" version="1">MLRRYRRALRDVAPLLALAFFVYSVYYFIIWAGRTLEARCMENGHCERVNLRCPEKASRAICSSDKNFFLAVGTYEGSATRRRCRDFWPEKIPLDAFNHVNFASAIISPDTYEVLPAHDRDIDLYARLIRHLGYQNDTKVLITLRDQQKLNSTGLMSSIFSELAASPQTKQRKFLSSLISFMTTHGFNGINLDLDLDFDTQDEKQQPDYTNLSRFVANLNIALSKMAGPDELSISFPASEAYLRRFDLKALHRYVSYINLKPYDGGAARGSRPVANAGVNTAEITSILEHLNCQDVNPNRIVWGMPFRGHSYTMADGCRSTDCAILSPGLAGHCSQEAGVLLNSEIVGIMQANVVKPQRVGNGAAKYLSWDNQLVTYYDNETINLQVEFARRQYLAGLMVSTVSDDVHDASFTKQFADACRRPAWIQRSAMIADMLKDDRLLRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLK1</accession>
    <name>A0A2I2GLK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PFU-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_431567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709053.1">
        <property type="nucleotide sequence ID" value="XM_024848067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLK1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLK1"/>
    <dbReference type="GeneID" id="36555766"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431567"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.870:FF:000003">
        <property type="entry name" value="Polyubiquitin binding (Doa1 Ufd3) protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000377">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="371"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="501"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="785" mass="83941" checksum="9838328BB55EFDD7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM02</accession>
    <name>A0A2I2GM02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_6136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709210.1">
        <property type="nucleotide sequence ID" value="XM_024855302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM02"/>
    <dbReference type="GeneID" id="36563008"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_6136"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="106" mass="11611" checksum="C53DB4BF92E1BAE4" modified="2018-02-28" version="1">MSVKAATGAMLIIVSTFNTFCSQSGSAPSLNRRFHSVRTLCRTISRIPQIQALEVSARRRIRPSSRQIRRLSGLRVQAVSMLLRGDQRPGQASLIDSSADCPRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM03</accession>
    <name>A0A2I2GM03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_504782</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709206.1">
        <property type="nucleotide sequence ID" value="XM_024854229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM03"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM03"/>
    <dbReference type="GeneID" id="36561935"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504782"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB53904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="734" mass="82032" checksum="F1AA164EA952E849" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM71</accession>
    <name>A0A2I2GM71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_451885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709284.1">
        <property type="nucleotide sequence ID" value="XM_024851232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM71"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM71"/>
    <dbReference type="GeneID" id="36558931"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451885"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="803"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="892"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="928"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="40"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="366"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="692"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB53982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1240" mass="135463" checksum="FAD79B59C15D3016" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMK9</accession>
    <name>A0A2I2GMK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_442283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709433.1">
        <property type="nucleotide sequence ID" value="XM_024850454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMK9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMK9"/>
    <dbReference type="GeneID" id="36558153"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442283"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="187"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="359" mass="39599" checksum="01737EFDE4055AB8" modified="2018-02-28" version="1">MPTSKCFEQCPPFPSDLPVLDLKRVSLAALEQKCPVEGERLLAACKEWGFFLLDMDGSDQGTALLRDAEEMFGLTADLSTLDEETLNKYHHKAPDFTRYKAIGTTKTAPGTFDHIHVYSLSQDDILETTPSSAQLPHPDTITHKKAQTYAFLTHSHAVLSHVLTSLNTALGIAPGTLSALTPLTEPSSTIMRLIWSPPSPHQPDYTRISFGGHTDMGIMTLLFNVLGGLQVLPPGAANIHQNWQFVRPQPGCAIVNVADTLEQWTGGLLRSCLHRVVTPPGDQAMLERRSVAYLLRPRQDASLARFVGGIVPPLQPGEVDETRTVDEWIEWRSRQIVKGQLKNESRVGGEDRNLCKDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNJ5</accession>
    <name>A0A2I2GNJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_432091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709749.1">
        <property type="nucleotide sequence ID" value="XM_024848186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNJ5"/>
    <dbReference type="GeneID" id="36555885"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432091"/>
    <dbReference type="OrthoDB" id="4510881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014135226" evidence="2">
        <location>
            <begin position="22"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="417" mass="40510" checksum="E745ECDE17CC4773" modified="2018-02-28" version="1">MHFTAKISIALLAALAAGSEANSHVRRNLHHRDLKQSGSVSAVTVFPTPAPAPTESAAPEQPPVAETPSAPAVETPPAAETPVSQSTSAAAETSVAPAETSSSAIPPPPPAVPTSSAVAIPGTSTAVIPSSSATSASSSAIVVPYPSSSKIPSGAAGQGSSSITAAPVPLSTGSTGSDASDIFSGTEDVTLTYTLGTGVSKSVVTTTIHKTATNWNTVYATASNAGSSGSGSGSDNDSGNGSGSGSGSGSGSGSEPVTTLSSTSTSVVTVIAVPSSTGSIGQQHNSENGQNGQSGQGNGECKPETVTVTAKETVTVTAAPAATNKPGENLIIDEPTSSEKPSQTGKPGQGAGEGEGEATATGIPAPSGPPYGNGTFPIHTPSSSAIPTPSSSAVPTPSGFLTSSKAAFPTAFRRRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNM2</accession>
    <name>A0A2I2GNM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_19458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709780.1">
        <property type="nucleotide sequence ID" value="XM_024842725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNM2"/>
    <dbReference type="GeneID" id="36550423"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_19458"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="116" mass="13684" checksum="13D60F7CE29899D4" modified="2018-02-28" version="1">MEKGFFITVMKGSVGLPMNRERRMSKIHLIHLLEASIHPRGPNAKLPKGARTPRVSSRWERWTWRMSLHGWSRGLLLLTCVMTQFCEKKFISFVYLFFFLSVHSSIRPAWTYVEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNU2</accession>
    <name>A0A2I2GNU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_432180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709841.1">
        <property type="nucleotide sequence ID" value="XM_024848205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNU2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNU2"/>
    <dbReference type="GeneID" id="36555904"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432180"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="3">
        <location>
            <begin position="118"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="705" mass="79646" checksum="4D64762D13244492" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP48</accession>
    <name>A0A2I2GP48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_470104</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709954.1">
        <property type="nucleotide sequence ID" value="XM_024852713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP48"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP48"/>
    <dbReference type="GeneID" id="36560411"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470104"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB54652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="239" mass="25844" checksum="0983A009DFC98085" modified="2018-02-28" version="1">MGGQSEKSSSAAPLGYLAPLCVAVFFVFVWAAVGTRHRYFRHTQHAGAAFDPENPSPHVRSSPIARSDVDKQFPLTEYSAWWEERNRKLATTHITQPGALNSSAEDGRGNGRTVDADGDHPLPSSGNKSDDVSHDPGEDGDDGPINVPLCTGDVHSLCAICMEGFDAADLIRPLTCGHIFHSVCVDPWLTKRQACCPLCKMNFSGYRMHPEEETPASSLAIPVLPGIAMVRSSIIPHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP58</accession>
    <name>A0A2I2GP58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_432286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709964.1">
        <property type="nucleotide sequence ID" value="XM_024848231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP58"/>
    <dbReference type="GeneID" id="36555930"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432286"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039553">
        <property type="entry name" value="Prefoldin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13758">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="3">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3835" evidence="3">
        <location>
            <begin position="527"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="603" mass="66700" checksum="CBC50F3FDAF67D2E" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP94</accession>
    <name>A0A2I2GP94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_432323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709996.1">
        <property type="nucleotide sequence ID" value="XM_024848237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP94"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP94"/>
    <dbReference type="GeneID" id="36555936"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432323"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="626" mass="69236" checksum="FCAF284FBDBFA6CF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP97</accession>
    <name>A0A2I2GP97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_24179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710004.1">
        <property type="nucleotide sequence ID" value="XM_024842959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP97"/>
    <dbReference type="GeneID" id="36550658"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_24179"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="20411" checksum="32AACE60640CABB0" modified="2018-02-28" version="1">MIGEVLWVVSIPDGFRDVPNREESVRSEGFFFFFFFVWFSFPSRFAASFPREDTSTKLFFPSSRKETNIHQLHRGDAQTELRFWLGSPGAVEPHTRFGPVGLSPRRNPEISMRLDCVDWFPAQRHVGPYHFIGPSWEPWDPPENSLFLSDCVELTSHTWENCFPPFLLVHCWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPA3</accession>
    <name>A0A2I2GPA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_460775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710008.1">
        <property type="nucleotide sequence ID" value="XM_024851965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPA3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPA3"/>
    <dbReference type="GeneID" id="36559663"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460775"/>
    <dbReference type="OrthoDB" id="3437771at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="153" mass="16734" checksum="A6944E898E5A4170" modified="2018-02-28" version="1">MSCANCPPPATKEATNSAPNEKSLSTRALQVCSIALPESFALLSCSCCWLPTILDLVFAGSVTAASLQNLRYVFLAISILSLAWGLRREGLSRSMICRIVISGGMLAWAQYKERTEETREAITEHRMSGRAILSPVKHSTFVSIRKFNPALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQC3</accession>
    <name>A0A2I2GQC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-ketosteroid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_421682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710370.1">
        <property type="nucleotide sequence ID" value="XM_024847383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQC3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQC3"/>
    <dbReference type="GeneID" id="36555082"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421682"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="434" mass="47707" checksum="E4DF57C4570047EF" modified="2018-02-28" version="1">MQDQTYVLVTGANSGLGFSICCRVVDEFLESTRQRTIDQSLTVIFTTRSTRKGNDTLRLLQDYLRTSANASAAARVTFIPENVDLSNLVSVRALSRRLTQTFPKLDAILLNAGIGGWTGIDWPRAVWDICTDPAHAVTWPAYKLASAGVVTDPQTARVDQEPRLGAVFCANVFGHYMLAHNVMSLLRRPGQSGRIIWVSSIEATVNLFDPDDLQGLRTTTPYESSKALTDILALTSDLPSVAPWVRSFHSIDDRTAADTTPQSSDPPLPPPNTYLSHPGICGTAIIPLALPLFYLMLAAFWFARVLGSPWHTLSTYLGARAPVWLALAPQSALDEAESAYRRHGGGRAKWGSSCGLWGPATSASTEVDGWGYGGVVGPAVVEEDRTRRRKRGATELTAEEKERFEELGRTCWQRMEELRVQWDGILDEVEKTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQL8</accession>
    <name>A0A2I2GQL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_347633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710463.1">
        <property type="nucleotide sequence ID" value="XM_024843643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQL8"/>
    <dbReference type="GeneID" id="36551343"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347633"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="12"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="529" mass="57501" checksum="F7E68126BEEE102D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQT3</accession>
    <name>A0A2I2GQT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_443094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710549.1">
        <property type="nucleotide sequence ID" value="XM_024850509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQT3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQT3"/>
    <dbReference type="GeneID" id="36558208"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443094"/>
    <dbReference type="OrthoDB" id="5416384at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000023">
        <property type="entry name" value="Fungal specific transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="692"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB55247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="836" mass="93445" checksum="5A07780204D48C04" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQZ7</accession>
    <name>A0A2I2GQZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_461209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710608.1">
        <property type="nucleotide sequence ID" value="XM_024852011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQZ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQZ7"/>
    <dbReference type="GeneID" id="36559709"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461209"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="265" mass="29207" checksum="18CBA296FA9A6FC7" modified="2018-02-28" version="1">MGRTLTYPKKSANTVNRYKHRATYDLGAIHSIVNSTQVLHVSFNPGPEDPFPAIIPMIGQMGSFDYPSADINEPLDCYLHGYVSSRIMNLARDSQKGLPICVAASKVDGLVLSLTPNSHSYNYRSAILHGYASVVTDEAEKLWAMELITNSVVPDRWNHSRVPPDRAEMSSTVILRVKVVDGSGKIRDGGVSDEKKDYADDEVTNRVWTGVVPVWETFGTPIPSSGNKVAEVPDHITGFVTSRNDQNRSYAHEAVGVTLPKEEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR45</accession>
    <name>A0A2I2GR45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase A</fullName>
            <ecNumber evidence="6">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_399418</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710651.1">
        <property type="nucleotide sequence ID" value="XM_024846280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR45"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR45"/>
    <dbReference type="GeneID" id="36553979"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399418"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001511">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000084">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="19">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="16">
        <location>
            <begin position="259"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="18">
        <location>
            <begin position="728"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="17">
        <location>
            <begin position="832"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB55349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="916" mass="103179" checksum="2F9BFC8FD49FA4E9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRM3</accession>
    <name>A0A2I2GRM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_422065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710828.1">
        <property type="nucleotide sequence ID" value="XM_024847411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRM3"/>
    <dbReference type="GeneID" id="36555110"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422065"/>
    <dbReference type="OrthoDB" id="4509852at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="158" mass="18051" checksum="30D26089B5B4B18C" modified="2018-02-28" version="1">MCPVQWSEEETVVAIVLSMWGVRPDTIATLLTRKSASIRGFLSDSSGPTNYRRTSGAVWNRLQRYRDNHKDLWNPDLGEWNSTAVCQFFLRSDLDKDLIIQFLSWTDGDVEFMVKCAEIDHLRPIESYHELRETLQALGIDHLSDTLSVALGLETSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRX2</accession>
    <name>A0A2I2GRX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_375496</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710931.1">
        <property type="nucleotide sequence ID" value="XM_024845320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRX2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRX2"/>
    <dbReference type="GeneID" id="36553020"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_375496"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="273"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="97"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB55629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="714" mass="77046" checksum="BE6D6A7116C50AC1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRY4</accession>
    <name>A0A2I2GRY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_506190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710936.1">
        <property type="nucleotide sequence ID" value="XM_024854370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRY4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRY4"/>
    <dbReference type="GeneID" id="36562076"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506190"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="78"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="402" mass="45079" checksum="EFC64F874C299B5E" modified="2018-02-28" version="1">MLSRSLRRAGALPWVRSSIPRPGRRCMASVANMDDIPTEDDRLFKVPISEQSYSTYNFDPPPYYVETTKNELKQIFRDMSMIRRMELTADGLYKEKKIRGFCHLSTGQEAVAVGIEHAITRSDKLITAYRSHGNTLMRGGTVESILGELLGRRGGISYGKGGSMHMFSEGFYGGNGIVGAHVPLGAGIALAQQYNDTKNVTIDLYGDGAANQGQVHETFNMAKLWNLPVIFGCENNKYGMGTSADRASAMTEYYKRGQYIPGLQVDGMDVLAVLSAVKHGKKFALDGNGPLVYEFVTYRYAGHSMSDPGTAYRSRDELQTQRSNDPLTNFRDRLIDWGVFTQEEAKSIDKEVREKMNSAKAEAENMPEPEQRMDILYEDIYVRGSEPRQRRGRTIDETFYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS07</accession>
    <name>A0A2I2GS07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="8">SDH assembly factor 3</shortName>
            <shortName evidence="8">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_506216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710963.1">
        <property type="nucleotide sequence ID" value="XM_024854372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS07"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS07"/>
    <dbReference type="GeneID" id="36562078"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506216"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB55661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="128" mass="14648" checksum="3E653B52C09CC3EC" modified="2018-02-28" version="1">MRPALRLLATPASMGSKSSLSESLALLPPLQLYRRILRVHRKKLEPEMRLLGDGYVKSEFRAHKSVDNPLHIIGFLTEWQLYAQKLEGDSWAGEKLDKAKLDKMSDQQLGQLYELMQAIRNRDGEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS47</accession>
    <name>A0A2I2GS47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_400000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710985.1">
        <property type="nucleotide sequence ID" value="XM_024846306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS47"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS47"/>
    <dbReference type="GeneID" id="36554005"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400000"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="375"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="492" mass="54354" checksum="748D142A032D249F" modified="2018-02-28" version="1">MSVTNPLNVFKGADSIKQFFNPDEQPPVPLVELPPKLNPFHADGVRIYAKLLTCLPAQNVKALPALNMLLNDPSSANKSVVEVSSGSTVTSLAIAARVLYDNDNSTAYVSNKAALDRVRELQFYGLKVDLYGGPTYTETTDPRGPVEWARGLGKRSDKVVNLGQYDNEHNWKSHERWTGPQIWRQLPEINVFCMGMGSTGCVTGTGKYLKAQKESVKVIGVCNAEADIIPGPREKPMHKTSPFPWKDVVDFLEVASSEDSYRLSLRLSREGIIAGPSSGMALQGLFEFAQREKDNGTLGNYADPETGEVSCVFVCCDLPQKHIETYFKKLGPEEFKPIGNQELFKVDQNVYSFRWEIDPQEILDSMPEITNGVTGSPAVRFLDLRSQADFESGHVKGAFNAHLPGLSADTITPFNFDEINTLVEQSKRLEELLQEQAISDWISNDGPPIVVVDYNGDTSRILVAALRAKGVEAYTFIDGVPGLQKYLDSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSC2</accession>
    <name>A0A2I2GSC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_484905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711086.1">
        <property type="nucleotide sequence ID" value="XM_024853918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSC2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSC2"/>
    <dbReference type="GeneID" id="36561616"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_484905"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="316" mass="35910" checksum="67C12A8962C9C29E" modified="2018-02-28" version="1">MVLSVIRTWLCDIIWPPTTQESDKSKNVAELPLDDPHPFRTNETGPGSSLNAQPSPFPQDPYIGIPVIGNGMTGIILKLGEDRAVKKAKQYKLGYLPDREDVEYMNEINQQTLANEIQVFERLGSYTGIIPYFQISQYGIELALAQGDLESHLETYPECENSLKISWMLSLIKTFAYIHSHKVLVDDIALRNILIPDGQLKLADFGQSILLPLDIDMASANENDLNVQIEILHLSWVLYSIPSWHVHKYYFFSPENPDLCWPEPDSFPNVDDILWGRIIKKCWHGEYGSMENVKDEAHQLLTSQHERCDPGDDSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSD0</accession>
    <name>A0A2I2GSD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_343520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711079.1">
        <property type="nucleotide sequence ID" value="XM_024843407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSD0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSD0"/>
    <dbReference type="GeneID" id="36551107"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343520"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="678" mass="75460" checksum="0F220204D7B16EF3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSF1</accession>
    <name>A0A2I2GSF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_443539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711113.1">
        <property type="nucleotide sequence ID" value="XM_024850558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSF1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSF1"/>
    <dbReference type="GeneID" id="36558257"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443539"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="831" mass="92263" checksum="902759530FE918C0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSJ4</accession>
    <name>A0A2I2GSJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dockerin type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711156.1">
        <property type="nucleotide sequence ID" value="XM_024848460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSJ4"/>
    <dbReference type="GeneID" id="36556159"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433322"/>
    <dbReference type="OrthoDB" id="5319191at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045690">
        <property type="entry name" value="DUF6055"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19527">
        <property type="entry name" value="DUF6055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014181039" description="Dockerin type 1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="46022" checksum="BE99F30096DD4B82" modified="2018-02-28" version="1">MSPSKQALAALLLSVTGTSAAPAPQASSSASDSFKANPDVGPGGSSYKDSDHFRLYGSATGGSDKVFGMMEAAYSCFVDDMEFTTSGLSILDDADQNSTLWKENIYATDGLSGGAAGVLQSDPTLGLSWLEVLPDFAADPSVLVHEYGHGLTYHSRTWVDQTATGAWWETIAQWFADTYITSSLCQKARSSHNQEAGNSIIELNKVISDSYQVIVDGTAESGNYYQAWPFFTYLTTNPDNYTGLGQDTVRQLFKQYKEGSNETPLHTLARVSTDASVAEIVGSYWAHMAYVDIDNSAAQEAFFSQRKDLNYENVESTGDGSYAVKSARQPQYMGANILPLTTSGVGTVEVTVTSSGTFTATLAVYNSESGAVRYVSLKNGKGSADLTANEEASIVVANTPESVIQYDGFKLSDDVKKGLDYTVKITGATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR54</accession>
    <name>A0A2I2FR54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_72241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698420.1">
        <property type="nucleotide sequence ID" value="XM_024855350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR54"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR54"/>
    <dbReference type="GeneID" id="36563056"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_72241"/>
    <dbReference type="OrthoDB" id="4150765at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="264"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="733" mass="80099" checksum="4D7A7572BB0EE667" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRA8</accession>
    <name>A0A2I2FRA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YggU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_481124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698476.1">
        <property type="nucleotide sequence ID" value="XM_024853837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRA8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRA8"/>
    <dbReference type="GeneID" id="36561535"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_481124"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="132" mass="14120" checksum="91B8E1EED7143583" modified="2018-02-28" version="1">MSGPSAPLLRLIQNVITKSRNSSPRAPARYSLQISCHVKPNASSNREGITAIDAAKVDVCVAAVPRNGEANTAVSRVLAQVFKVPKSSVEVIRGLKSRDKTVSISDLDIGAEGENKFLQKARGKLEEAILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSW5</accession>
    <name>A0A2I2FSW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_60940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699016.1">
        <property type="nucleotide sequence ID" value="XM_024855299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSW5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSW5"/>
    <dbReference type="GeneID" id="36563005"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_60940"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="390" mass="43280" checksum="FC404612F815F7CC" modified="2018-02-28" version="1">MNSPDRSHPLKLPPIILGGAGFSYQIHPDPKSIPIPQIIRRAFDVGMKAIDTSPYYEPSEQLLGEALASTEVTSKYSRSDYVLMTKAGRISADQFDYSAKWIQKSVQRSLDRLGTSYLDVVFCHDVEFVSMEEAIEAVGALFELSEKGQVRFVGISGYSIDRLVRIAHTVKKQYNRPLDIVQNWAQMTLQNTRLERYGIPALRDAGVSTICSSSPLASGLLRAGDVPSGKLGDWHPAPDGLRSAVKESSDWVEKQGSTLAGLALRFSLARANRASKNGVSVHTILGICSLSDIESNVHAAQTIFQTKHESDELDISALEDINEEIERVDLGLSHKVRGILGEWVEFDFETGKKESKVPLWRRREFIAAAILLLPVLVWSSGFNPIAWWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT71</accession>
    <name>A0A2I2FT71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_459410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699131.1">
        <property type="nucleotide sequence ID" value="XM_024851864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT71"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT71"/>
    <dbReference type="GeneID" id="36559562"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459410"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="314" mass="34634" checksum="97A5040C45500B95" modified="2018-02-28" version="1">MSTIIQGSMNGGAVANSLFEHPDIYHVRALTRNAEKPAARALAERGAELYCADLSSGRDALATAFSGADVIFALTDFWQTQSTDIEIAQGKAIADAAAQTPTLKHLLWSALPDPVALSGGKFLNYAELWAKTTTILFPNYFENCLTTPDRYLPTKDASGIYTLSFPHSLDTVMPNVAIADTGKLVLSILAAGSHYFEKTIAFYSQALSEADKLATIRKSTLLHHPSCSRLIHKIGYNVPTQYRKLTSSEFQEMLQARDGMSEEIALDFAEQLMIFEECGNVYANEEFVQAYEIPGLKLQTWAEFLDKHELPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTG2</accession>
    <name>A0A2I2FTG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_459437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699169.1">
        <property type="nucleotide sequence ID" value="XM_024851868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTG2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTG2"/>
    <dbReference type="GeneID" id="36559566"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459437"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="578" mass="64733" checksum="39703C3FE5CFC6D5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTL2</accession>
    <name>A0A2I2FTL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699290.1">
        <property type="nucleotide sequence ID" value="XM_024850308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTL2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTL2"/>
    <dbReference type="GeneID" id="36558007"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441425"/>
    <dbReference type="OrthoDB" id="5408998at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="724" mass="80827" checksum="45BCC8B1CE3E1451" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTS8</accession>
    <name>A0A2I2FTS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complexed with Cdc5 protein Cwf18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699316.1">
        <property type="nucleotide sequence ID" value="XM_024847998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTS8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTS8"/>
    <dbReference type="GeneID" id="36555697"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431003"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="200" mass="22635" checksum="D51F442AEE25E81A" modified="2018-02-28" version="1">MASHHASLDAAATERKARLAKLASLKRKQPEPEAPTEDENHTREEAMEDDEHDVSTRYLSGRNYDAETRGPKLGFDQNPLDGQANLEAQAAEIATATAEQAKKDEEADQPIDLFKLQPKKPNWDLKRDLDEKMNVLDVRTQNAIARLVRQRIENAQRAAKAKSKDINSDKQGEEVGIEGEVLVEGIHMREREEDERDRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU71</accession>
    <name>A0A2I2FU71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_440490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699418.1">
        <property type="nucleotide sequence ID" value="XM_024850090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU71"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU71"/>
    <dbReference type="GeneID" id="36557789"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440490"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="256" mass="27764" checksum="CE060B45DBE91DF6" modified="2018-02-28" version="1">MSFATTDDGQEIYYELHGTSGPLLVCISGYFGVSDLWKPLISLLGSNYRCLTLDSRGYGRSSKPDTPELYSVPRHGEDVATVLKTAGLSAEPKILLTHSMGGNIASSYFLSHPTSVSGIIYTGTYYDGPNMARFLSREDLWAGAESPSKCVDFYANMKLSKDIAQEAAKWPAHIRKHNGIALASFAMAGRYAEITVPTAIIQGAEDFAGPIGITIDPMVAELPSCKLTTLPGVYHFPPTEAPFEVKQAIEDFIRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUT2</accession>
    <name>A0A2I2FUT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_430227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699628.1">
        <property type="nucleotide sequence ID" value="XM_024847940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUT2"/>
    <dbReference type="GeneID" id="36555639"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430227"/>
    <dbReference type="OrthoDB" id="4471885at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014133788" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42940" checksum="EC4B5DCB7E087F2F" modified="2018-02-28" version="1">MKLHTHAIEWMTSLQALLWAILPSHTSASPFISSPDLVHYDVPSKNSNIIDEPPPKSKRKTNYPAVTFSSTCSPVQRQYIIDELSEIETMLNEAQTQITTMLQIIRERQQPKDWGPRFDENTRLLNTWQAYVEKIQLNRRATLGPGQAPRSPWKVAEGNMKTMYEKYYNMDQVLKAQALNVMFHCDDTFLKYQEKESNKSFRLYKDERNEATDGPRNANIPLPASLRLCHESTSISGYRYTNSVSGQEEIYICPITFEKAKTSNKLTQFANEMSTLKGKTIDEIFFNSTANTIFHELTHCEHILGNERTADQVYVKNGKSLKAYQASGIMELSYFRPDLSLKNADTLTYFALGSRGSTEEAPKMPRFCQLSGIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUW3</accession>
    <name>A0A2I2FUW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_450491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699658.1">
        <property type="nucleotide sequence ID" value="XM_024851128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUW3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUW3"/>
    <dbReference type="GeneID" id="36558827"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450491"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="165"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="497" mass="56823" checksum="FB3C8ABB6E3662D8" modified="2018-02-28" version="1">MPPPLPSHHRGMTANPVRPGRYRPGKAVAEEPSSEEEEDDDEAEAEAEKARIEERRRQERLRREQAKAPPPKASSFPAGAVTKGVKNVKIQEEDDEEGFVTEEEEEEEEEEGGKVAPRVAGDNVGDASAPSAAAAPVDKVPARKEESSEEGSEEEEEESSEEESSSEDEAPRRVLLRPTFIKKDNRKPAAPAQDGQGPAPTSEAPVDSGADSEARKAQRQEKADMLIRDQLEKDAVARSTANRAWDDDDELEFAEEGAIDDKDGVDPEAEYAAWKLRELKRIKREREAIEASEKEREEIERRRNLTAEEREREDNEFIARQKEDKEANRGQTGFMQRYFHKGAFFRDDLEREGLDQRNVMGARFVDDVSRETLPQYMQIRDMTKLGKKGRTRYRDLKSEDTGRFGEGFNNRRRFEGAPEGITDERFMPDRRDDRPKGPTGANAGPVRERRRSRSRSPRRDRRDRSGDRYRPDDSQRRKRSPSPYDDRDKRRRVGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV83</accession>
    <name>A0A2I2FV83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_288062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699836.1">
        <property type="nucleotide sequence ID" value="XM_024843219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV83"/>
    <dbReference type="GeneID" id="36550918"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_288062"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="128" mass="14230" checksum="A39C01CFE4A22051" modified="2018-02-28" version="1">MKHPECSIPRGEGEQFRVQTPLESSILRTRKVIHRVHHPNKQRSTATAQPTPTSHGAELLMKRSTSVEPSAEQPTPSSKRKPNPSSQTNKNNPPQTISHDKNNNDRSSFSPPAQPLTVPRRADRTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVP2</accession>
    <name>A0A2I2FVP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein CFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cleavage factor two protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein cft1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_415338</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699997.1">
        <property type="nucleotide sequence ID" value="XM_024847059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FVP2"/>
    <dbReference type="GeneID" id="36554758"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415338"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000625">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000788">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="13"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="555"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB44695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1389" mass="151215" checksum="FFD02C0B0494C270" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVR1</accession>
    <name>A0A2I2FVR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_265617</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700024.1">
        <property type="nucleotide sequence ID" value="XM_024843114.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FVR1"/>
    <dbReference type="GeneID" id="36550813"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_265617"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1204"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="493"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1092"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1288"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1304"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1343"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1366"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1401"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1421"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1511"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1540"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB44722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1666" mass="184722" checksum="CF25BFB21510895D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW17</accession>
    <name>A0A2I2FW17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dimethylallyl tryptophan synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_415603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700141.1">
        <property type="nucleotide sequence ID" value="XM_024847069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW17"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW17"/>
    <dbReference type="GeneID" id="36554768"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415603"/>
    <dbReference type="OrthoDB" id="5392033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="438" mass="49788" checksum="F5BC9837A93C750C" modified="2018-02-28" version="1">MADSQKPATLLSKPFYVLSGSFNFSNRDHARWWYSTAPMFAAMMARANYDVHAQYKFLCIHREVFIPALGPYPERGQPMRWKSHLTRFGLPFELSFNYSKSLLRFAFEPLGPRTGTVEDLFNTQAAGPVLQVLKTMVPRLDLEWFDHFTKALVVSDEETRSLYEANIPIPVFKSQIILGADLAPSGDMVLKAYVYPRIKSIATSMPKETLMFDAVKAVDSERRLAPALSILEEFMAERAPTLIGHFLSCDLVQPSDSRIKVYCIERQLNLASIENIWTLNGRRMDTETMEGLQMLRELWQLLPITEGLCPLPDCFYEPGTSPHEQLPFIINFTLSPNNPLPEPQIYFPAFGQNDKIIAEGLATFFDRRGWGGLAQSYPTDLAAYHTDVYLGTANHLQAWVSFSYRERKPYMSVYLHGVDTCGVYQEAISVTKDRATDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWF4</accession>
    <name>A0A2I2FWF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_415726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700198.1">
        <property type="nucleotide sequence ID" value="XM_024847077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWF4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWF4"/>
    <dbReference type="GeneID" id="36554776"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415726"/>
    <dbReference type="OrthoDB" id="5404004at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="584" mass="63858" checksum="F9343F34C12866C2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWH2</accession>
    <name>A0A2I2FWH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_450016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700259.1">
        <property type="nucleotide sequence ID" value="XM_024851087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWH2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWH2"/>
    <dbReference type="GeneID" id="36558786"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450016"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29766" checksum="C8C8CF15222700D5" modified="2018-02-28" version="1">MPHFKEDYLPVRHDSDSIGEVPSCDTEALLLQSKERYRRWKYTLQILTGICVALYIILLFGIFFLFKNPQVVITDQRCARQLSITGPGLDSVEYETIMFKGAQEGDNPYKGHPGPDLDAAWSQLTEVRHVSVSPEIMVSINKSNNNAVQLADGTYFGATEVFHQLHCLNLIRQHSYKEYYDVDGRRPPGLTDSSATLRKHLDHCIDILRQNIMCNGDTSVITHNWVQGYEFPYPNFNTKHKCRRFEKIVEWEKDHQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWH4</accession>
    <name>A0A2I2FWH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700276.1">
        <property type="nucleotide sequence ID" value="XM_024850009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWH4"/>
    <dbReference type="GeneID" id="36557708"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440155"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="89" mass="10329" checksum="CE6C51F67F2D0E2F" modified="2018-02-28" version="1">MFHCSQSTHLQSSLQQPDRSPEACVEGTDQQTHLQSSPQQPDRSPEGCHERQRKERKKRESLCQTKPTRQQQQGLNQLSQLHGRRKNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWV2</accession>
    <name>A0A2I2FWV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_479631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700406.1">
        <property type="nucleotide sequence ID" value="XM_024853700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWV2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWV2"/>
    <dbReference type="GeneID" id="36561398"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479631"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="412" mass="46663" checksum="04B12B4662113FAA" modified="2018-02-28" version="1">MSHFKVIEHQARCQNIRERPGAVEPRHEHQLRLAVKQYIPKDNLNPKEGDVTLIGAHGNGFPKELYEPLWDGIYEKLRAANRRIRSIWIADMVHQGQSGVLNESILGDDPSWLDHGRDLFSLVNQYQDEMPHPIIGIGHSMGGMQLAHLSLMHPSLFQALVLVDPVIQTGNPSKTLALPTTYRRDWWPSRQEALQKFQSSSFYQAWDPRVLEKWVEYGLRDTPTELYPQASENGQQPVTLTTTKAQELFTFLRSAYVDKRSGLPRGTPQGEVHPSEIDDFPFYRPEPAHIFRHIPELNPSILYVFGENSPFSTPAARQEKIQATGTGLGGNGGVSQGRVKEAVLPCGHLVPMENVSGCAAASASFIEDELTNWEARMRKLRGAWKGVPRQERISIDDQWRAHIGELPRRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWZ8</accession>
    <name>A0A2I2FWZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700439.1">
        <property type="nucleotide sequence ID" value="XM_024850040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWZ8"/>
    <dbReference type="GeneID" id="36557739"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440275"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="155" mass="16912" checksum="7B06BD9F66B5E7DF" modified="2018-02-28" version="1">MNVIRFYQRRSPSFYGALSSRMLGIPRHGHQFHASHKRGPFTQNIPPTSPGRPRFTRFTKVAFLLGLIGAGSIAYTKSQKPPPGGSSGAVPPPANKTNVPSSPPPVQLVDPRAKERISIHRSLRQARSAKEKAPLVPPNDSIKPGNTEPKEKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX20</accession>
    <name>A0A2I2FX20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_429880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700492.1">
        <property type="nucleotide sequence ID" value="XM_024847920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX20"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX20"/>
    <dbReference type="GeneID" id="36555619"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429880"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51786" checksum="705B03692CE4A188" modified="2018-02-28" version="1">MSVPWSLDPPPAYEELDPSRLTPPSHGIGQSRFFRSTTSLTLDPSAGGDEKRRLLLIYVHGFMGSEESFQNFPKHVHDLLTISLGESHVIYTKVYPRYKTRGPIHVARDQFSQWLSPHEAPDLDIILLGHSLGGIISSEVALVSRNHRLKHRVLGLVNFDVPFLGLHPRVVATGIGSLFHRSPDDPSDPESTPSPGGFNVPDQNQTFDPAFSNDLHLARWKGWGGARHFISKYSENLSRSLVRYFFSYYDHAGCMNNYPELIKRHRKLLELEAIDDWNTPADSGVNRIRFVNYFTTSTGPAKKPKKGSAQDEHSRRESDTSSVSQTDTKSLESEQKPTTDYDKHDGVGTEHTQDHASNKNKGDGDREGDGDGDEENSPPKSLRKFCYLPKDSIKGRDDLWVPVLMEGVDEVVAHQSMFLPRNIYYDRLVGDTASRIESWIHDDLTKRAVLDGEIGKSAGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXM9</accession>
    <name>A0A2I2FXM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700691.1">
        <property type="nucleotide sequence ID" value="XM_024849777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXM9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXM9"/>
    <dbReference type="GeneID" id="36557476"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439158"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="335" mass="36951" checksum="5A0FA2DA6EE5D60D" modified="2018-02-28" version="1">MPKLVPSAVSTRPIRNHFHPPRPANFRKHFSSPFRPLAQPRQDLFLHDPWQSPTSSPTLFAQTGFNQSVSDGLRKDLNGGDHQSPDERVLKLGKTLRILSPLLPTLLVNPLPSSILSPSVTLHLFPSTHPHLPTVKGRTLYRAALWTVPVAWSSLPLVGNVKLQILSERMVRSGTVLDPERCGHGDCGDERLVVRWRTEPRRDDHPQIPSSLGTKRGAQDEPSHVSASKNGINKGLSMLLGGDAPIFKLAKEEQFTGLFIFSFDEEGRVLSHTIEHADNASGWERTAKFVSLTDWLIGKARGSLDPAAEPGLAIQGCQSFEPCSSRGASRFSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXU3</accession>
    <name>A0A2I2FXU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_364014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700708.1">
        <property type="nucleotide sequence ID" value="XM_024844622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXU3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXU3"/>
    <dbReference type="GeneID" id="36552322"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364014"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20311" checksum="03FE60AAE3B2EC82" modified="2018-02-28" version="1">MVPLDDPLKNFTVALHFACLQNDADQVTQLMRMGARRDALSESGASALEVADQLNRVEVVKRLMADVDVEKMGLLELLYAIRRGQSTVVHALMEMGVKEQLQDIVVFRGVFLMACAFSNTLVVNALIRHGRPLNVAAFEEILVYIARLANNHAIAELIREISGEQRRRFFRTTMVSHSPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXV5</accession>
    <name>A0A2I2FXV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cornichon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_478432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700771.1">
        <property type="nucleotide sequence ID" value="XM_024853560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXV5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXV5"/>
    <dbReference type="GeneID" id="36561258"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478432"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="138" mass="16146" checksum="FBFD772C1A6B9030" modified="2018-02-28" version="1">MSGEAWLYLLAVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNAYIIPEAAVHGFLTFLFVINGYWLAIVLNLPLLAFNAKKIYDNQHLLDATEIFRKLNVHKKESFIKLGFHLLMFFFYLYSMIVALIRDESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZK2</accession>
    <name>A0A2I2FZK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_439755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701364.1">
        <property type="nucleotide sequence ID" value="XM_024849911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZK2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZK2"/>
    <dbReference type="GeneID" id="36557610"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439755"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="92"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="220" mass="25061" checksum="CDF97C59B3248568" modified="2018-02-28" version="1">MSPKPIVLYIHPSGPNPWKVVAVLEELSIPYETRFLHGAAIKQEPFISVNPNGRLPAIEDPNTNITLWESGAILEYLVETYDKERTVSFEPGTPEYFHAKQWLHFQMSGQGPYFGQFVWFSVHHAEKIPSAQERYLNEVKRVSGVLDKFLEGREWLVGGKFSYVDAAFLPWFGIMGRFTGDAIDLEKDFPNLDAWLKRLNARPAIAKTQKDRAAAAESHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZU3</accession>
    <name>A0A2I2FZU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_415045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701449.1">
        <property type="nucleotide sequence ID" value="XM_024847044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZU3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZU3"/>
    <dbReference type="GeneID" id="36554743"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415045"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014173983" description="Protein ROT1" evidence="12">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB46147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="235" mass="26251" checksum="964B1D8D5F385491" modified="2018-02-28" version="1">MIVGYLYLGLLATTASAAKVADLVGTWSTKSGSVVTGPGFYDAVKDKLIEPDLPGISYSFTADGHYEEAYYRALANPTNPSCPKGIMQWQHGTFTMDSDGSLELSPIERDGRQLESDPCSSSLGTYTRYNQTERFNSFKVSVDPYHNVQRLDLFSFDDSPMHPMYITYRPPQMLPTSPLESVTKDAKRKRDVGSQTESPFRMANLIKREDLVNPDRWLWLGIFMTALGGITVFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G083</accession>
    <name>A0A2I2G083_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_479211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701600.1">
        <property type="nucleotide sequence ID" value="XM_024853649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G083"/>
    <dbReference type="GeneID" id="36561347"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479211"/>
    <dbReference type="OrthoDB" id="10632429at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="142" mass="15876" checksum="D8B28C7F0613D1D3" modified="2018-02-28" version="1">MSTLTKFTPSTPKGRRSRSPYLSAKTATILILAISIFLFLISKFTLPSFTTSQSPDHSINQDLYPDIQVAEQNFNPNADCDLDLDPDIESEEHDCPYSVPHTQRGSEKKQKNSWNSSSSGEFWISDLGPIERIHVKLNSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0G5</accession>
    <name>A0A2I2G0G5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_215217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701674.1">
        <property type="nucleotide sequence ID" value="XM_024842828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0G5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0G5"/>
    <dbReference type="GeneID" id="36550527"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_215217"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="73"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="292"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="491" mass="55849" checksum="573C5711E0D8E217" modified="2018-02-28" version="1">MSSNAPVAVDPWTEAFNILDPEDQKRLNQPDTSLLDVLESIKIDTDSRKEICREKGWKVGENKNGEKVTLRHVLEKVSVWVKETIKVVDVVVSMDKSGQAALPWAAVKFLISIGTNDIALFTNIAEAVETIARLIARYTVFEKLYLHEDCESMLKLRESLRELYAAILRYLSKAKDYFTGNCLKRFGRGLLDMLRKEYDELWAKINETEVERWAKLVDAELNRKTAKQAGEQHEQLKTILHNMEQPIMHVSHQLAAIQDKLDSDERMEVFHWISRIEYKKHHEELSKGVLPGSGAWLLRSPEYIQWGQSSVSSILWLHGIPGSGKTKLVSAVINNIQQHSTSPVAYFYCNRSNAEGERSIPREIIRAILRQLASSDPDVPIKEPVVREYESRKEQAQKDGSSLRELTIEDCTKLIREITRSNPATIIIDALDECDQFTCHELLDALHDIVAGSEEVVKIFVSSRDDVDVIVSPTVSSEDYCHNLTCPRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G186</accession>
    <name>A0A2I2G186_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine rich repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_361682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701942.1">
        <property type="nucleotide sequence ID" value="XM_024844479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G186"/>
    <dbReference type="STRING" id="1392250.A0A2I2G186"/>
    <dbReference type="GeneID" id="36552179"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361682"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="814" mass="88776" checksum="AEE20F59C5C024EA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1M3</accession>
    <name>A0A2I2G1M3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sin3 binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_221617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702065.1">
        <property type="nucleotide sequence ID" value="XM_024842864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1M3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1M3"/>
    <dbReference type="GeneID" id="36550563"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_221617"/>
    <dbReference type="OrthoDB" id="5391991at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="40344" checksum="6E8318EE9B378AA3" modified="2018-02-28" version="1">MAAPITTSSIAMALAGKTASVDIPKPRSAFTADGDASCHPALLPTPPNSISPTLPPQAFKRRDNLPGSPSFATSQFDSDIDLGDAAQHAVSRAQHLSPGDVDSAGAITPEMLSHYHLPDIMLQHGPLAIRHIMGYLTTSVPGFSRIAPAKSRRLVVAALENRGICDKGSGAESEIVFEKVGWGRWDARRRGEPLRDARQPNLSPPSSLSNSFPQKAMQIPIKRDSLQPYGSSITGDSAVFSYTERDYVGHEDVSMLEHEADKMSLDGDEREYCSSSEAPDDEIPDGDWGEEDVTDEEDWAQIGAAALRARSLNGGGGFVHGKHPPPQLRGGGPASSSLAKSAPQKIPIQQLGFSLPDGVVNDREERAAVEALLRLGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1V8</accession>
    <name>A0A2I2G1V8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_511537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702167.1">
        <property type="nucleotide sequence ID" value="XM_024854899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1V8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1V8"/>
    <dbReference type="GeneID" id="36562605"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511537"/>
    <dbReference type="OrthoDB" id="4227542at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF1">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine zipper 2TM" evidence="2">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="202" mass="20951" checksum="A2E3393F7DFF5DF2" modified="2018-02-28" version="1">MSGPYDQYNQQGYGGGYGHNQGYQQQGGYPPQGGYQQGYGQSQHQGYGQDYNRGGSSGDYYGGSSGGSSNDYYGGQQSHGQHQYGQQSHGQYGGQDSYNQYGGDQQQAPGGAQEGERGLGGALAGGVAGGFAGHKADHGILGTIGGAIMGSIAEDAIKKHKNKSEQQQGPPDYASGYGSHQGGPPSNQGGMMDQLGNFFNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G270</accession>
    <name>A0A2I2G270_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_428217</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702267.1">
        <property type="nucleotide sequence ID" value="XM_024847832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G270"/>
    <dbReference type="STRING" id="1392250.A0A2I2G270"/>
    <dbReference type="GeneID" id="36555531"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428217"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014158711" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB46965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="196" mass="18816" checksum="09B0D658A1033553" modified="2018-02-28" version="1">MKFHYLSLALAACLSTAAAQGLDSLPSCAKGCATDAIPDHCGMIDVGCICSDKSFISSISCCVSSKCSDDDQKSRLVPAVIQFANQICSGAGVKDLPKSASCASGASSATESSSEASTGSASSTATGQSSDASTTGASKASATSGSSSSSETASSTGTSTGTAESAATSTAGAALVQGKDTSLLAAAGAALFAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2I9</accession>
    <name>A0A2I2G2I9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_448773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702393.1">
        <property type="nucleotide sequence ID" value="XM_024850992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2I9"/>
    <dbReference type="GeneID" id="36558691"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448773"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="399" mass="43461" checksum="BFDE1B16CA73B4BC" modified="2018-02-28" version="1">MAAASTCSVRHPVHGAYCDNGPPHGAHINSSHNRPLHIVPQPALASSPPTTNPGDVSTLSAVEVDLASQSISSLNIMEVKETMLHVTELPLESPGLAVVEQPSSPKMESIQESTSTGLDVPAATSSPASAKRRTPKRKRTASPPSPASTTPSQHLRSTSRSTRRSAPPGSRHSSLHSHRRAVTTSSLTPSSQPSPSDPETRRQHLLALHRESCRLFQNNGLVKETEPNTPSPSSTGALHSTPPRTVRTYSDLSTPPLSPTLHSMSSRTAQRPHFPPPRRTCSAFTARDSEPISPIHPSTTVIDWTSPSTRRREYKKIDRASSGVRGFWRRVAPRWARFGGDRTPFFEQDKDGKGNYEGSVRRFRMDLPDETPAVPERAGTMRGLNLKRKLVGRTRSDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2K1</accession>
    <name>A0A2I2G2K1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_466437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702403.1">
        <property type="nucleotide sequence ID" value="XM_024852415.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G2K1"/>
    <dbReference type="GeneID" id="36560113"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466437"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1610"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2501"/>
            <end position="2524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2524" mass="285508" checksum="A9BC51F314F5F5A5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2N7</accession>
    <name>A0A2I2G2N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_466469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702446.1">
        <property type="nucleotide sequence ID" value="XM_024852418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2N7"/>
    <dbReference type="GeneID" id="36560116"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466469"/>
    <dbReference type="OrthoDB" id="4510929at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="474" mass="48476" checksum="E846C740BE05187A" modified="2018-02-28" version="1">MTDKPRKFEPAGRQSRRVLLSLGLGSSREALASLLISLSPSLFVGAFYLVCLFICVTIPDIESLSTRVSIPISASAPAAVSGPLLSLSAPSSSPAITPAGLHGGDAALTVSAASAASGSLPFPSLSTSAETDGGTASSSVVATDTTAAAAASVSASGPGPGLPRSPTLVRIPTTIPPPATAPATAPTSLKPSTTSSHTEPGTPIYRRPRSLSFYDASTSSDAILPQNRHLIQNEGGIGTSQHAAATRDAATRSPRKTGLIITPSGAPNPGFKGSASPSISAFRRVVSASASARNRTSSLSPALAPQYQPQASASASARRTSYPFRAEDLNAAYWRAAEGSGFRESIDTRGYAPGGESPVRGILKRRHAVMARDFTAPEKKVTFAESGQGEGEGEVKGELDEDWLSELIQSVLRVTLDEGEGEASSGSHVQGSVGQGSGGVVSARGDVSGGRVSGHVVDSDEEDVFPAEEFCHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G423</accession>
    <name>A0A2I2G423_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_476313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702932.1">
        <property type="nucleotide sequence ID" value="XM_024853336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G423"/>
    <dbReference type="STRING" id="1392250.A0A2I2G423"/>
    <dbReference type="GeneID" id="36561034"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476313"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="423" mass="48246" checksum="096CF6382B699AAB" modified="2018-02-28" version="1">MQATFNTLGSYAAPYIRDTLLRMLQSNIQNGAIDIHLKGACSQQRSGALKVGNIECTDSGVLKASLVVHDDPTLWLKLCQNLDIGVAEAYMLQQIECSDLVSLFRIYIRNWTSMATVNSLVQLPLRLWNQVTRKINNTANAFQNASFHYDTSKALFKAFLSEDMCYSCPIWESPDEPLEAAQRRKAQTIIDKANIRSTDHVLDIGGGWAFIAMEAKILGEELIKGRSYEDNIDYVLCDYQNIRKPERGFDRIISVEMIEAVGKEYIDEFFGTLHNLLNPIEGRIVIQSITFIEKLHSQPKSLDNFLDKYIFPGGYLPCNTELINSMSRGSEQCMELDSLDEIGENYVKALRLWREKFVSNWETIKSSILREHGERSDAEMEAFKRIWIYYFSYCQAGFHEGILGDVILAASRRPRVMSHSPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4U9</accession>
    <name>A0A2I2G4U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_200244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703208.1">
        <property type="nucleotide sequence ID" value="XM_024842757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4U9"/>
    <dbReference type="GeneID" id="36550455"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_200244"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="224" mass="25448" checksum="850BBCD3B3B8CB78" modified="2018-02-28" version="1">MRIPSLHTSNIQHTYSALVPPDLEYGRRHPLPLIRPAERANPLRSLPSVRKIDNGRLRDDGGVVEGEKVVGVSSRCSIVHHPIPSIHQSRPGQANSCSPLRFLILNFPFFRFVERSGGCLLLLVFVLLSPPLSQTDGPHSILPSQSHILGNKAHALNPKLEMKKRTRTQCSKPFEMYKLIQTKHSNIINKKQEKNSDHACRKSNEKVRERKKKKKKKKRKTPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G582</accession>
    <name>A0A2I2G582_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-arginine deiminase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_456703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703339.1">
        <property type="nucleotide sequence ID" value="XM_024851645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G582"/>
    <dbReference type="STRING" id="1392250.A0A2I2G582"/>
    <dbReference type="GeneID" id="36559344"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456703"/>
    <dbReference type="OrthoDB" id="544103at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377:SF0">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54262" checksum="FE7B20453597F9BB" modified="2018-02-28" version="1">MGIRFLNPSRVGRLSKATLSKSKYPFHASCLHHHQQRQQQQQQQQQQQQEPKYYLPHESTPHAATILGFPSRQSVSKALHAGTCREIVDLAATIAGFEPVRLYTRPEDIVSARELVKQRIHHHPASKIKNPSLRQDSQYQNANATTTTYDLASQIHILPCPTNHCWVRDTGPVFVRPAASTSPSTTSSHRRFAIDFSFCEWGNKHTDNVPDPNPNPTKDDADADPNAWPIPSPTTLAENTGFAARVIASFPASSTGPISRIPSRIRLEGGGIEVDGQGTFLATESSILCAERNPGVTKEAAERELSRLLGIRKFIWFPGRKGLDVTDAHVDALVRVVRPGVVVVSRPYGYSHHLTTSTSSPPAAATDAATARTRSEWMAVYEEIQSILARETDAHGRRFEVHEIEEPDPQYVKRDVDEGHPAASYVNFYFVNGAVVVPVFGDPGADERAVLTMRRLLPEREVRTVRVNCLPRMGGVLHCVTQQVPVLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5X7</accession>
    <name>A0A2I2G5X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_361363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703555.1">
        <property type="nucleotide sequence ID" value="XM_024844466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5X7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5X7"/>
    <dbReference type="GeneID" id="36552166"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361363"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000074">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="5">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="6">
        <location>
            <begin position="156"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="368" mass="40823" checksum="C0B084961D752AFA" modified="2018-02-28" version="1">MDKRVTLLEPPALDASKAPIENVLELTPVVDIGPDVFTNTRPLWHPPGARGIYGGAAIAQSLSAAMRTVPSDFAVHSMHCYFVLAGDSEIPILYHVERVRDGRSFITRTVQARQRGRPIFTTTLSFSKANSGGKKKLEHATPMPTVPLPDLAPPGSKKQFDEGGGGPFESQKAGVVNRKWDANPADKRLRRFVRARGRISDGGGHHAHLSALAYITDSYFVGTVSRVHDIPRFTSPGELKQFLNALKNPSDLDDEDISRALKELKEEETAELRRRLEGALSKATDEKNKAEHKEVGMMVSLDHSIYFHNPWAFRADEWMLTEMESPWAGEGRGLVLQKMWSKDGTLIATCTQEGVVRLKQDEPPRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G777</accession>
    <name>A0A2I2G777_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_358870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704035.1">
        <property type="nucleotide sequence ID" value="XM_024844321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G777"/>
    <dbReference type="STRING" id="1392250.A0A2I2G777"/>
    <dbReference type="GeneID" id="36552021"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358870"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="39"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="424" mass="46928" checksum="E1C40E1E9CC370F2" modified="2018-02-28" version="1">MEAISARGRDFAAQNPTFLSVLSDSWDSQSNPNGIVNLGLAENTLMHGEMQEFMNSKVQIDAHALTYGDGFSGSHRLKEACCQFLNRHFSPWTVLSPSNLVVTSGVSNALECCAWALADRGDYILVGRPYFNAFKTTFGTRPGVELLEVAFATTDPFSLAAVKEYERAYVEAISQGLCVKALLLCSPHNPLGRCYPEEVLKEYMKFCARNGLHLISDEIYALSTWENPRLPEAPGFKSILSLNVRGLMDPSMLHVVWGLSKDFGATGLRVGCLISPSNRLTLDAAEGVSLYNFPSSVADQIAASLLLDHEFTEQYITTSRRRLSTSYDLVTTFLRTHDIPYIECNAAFFVWINLGAKTEGRGITDTEITAQLRQEKVYIAAGKAYAAEEAGWFRLVFAHPQHVLQEGLERMLRAIDSMANPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7M4</accession>
    <name>A0A2I2G7M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_407617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704181.1">
        <property type="nucleotide sequence ID" value="XM_024846692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7M4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7M4"/>
    <dbReference type="GeneID" id="36554391"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407617"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="67812" checksum="1FDB5B8A3118B6CC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8C8</accession>
    <name>A0A2I2G8C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_475444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704430.1">
        <property type="nucleotide sequence ID" value="XM_024853261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8C8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8C8"/>
    <dbReference type="GeneID" id="36560959"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475444"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="227" mass="24597" checksum="851C66E8EF830BE5" modified="2018-02-28" version="1">MELSNGVNHKKPVPSIDRIAVLEQDAPLLSLMTRIRDESTSHRDFCAAVDRIAQRLITLALNHVPVDSHTITTPTGATYPGVQYTKGVCGVSVLRAGASMEHALRNTWMGPLTFGHILIQRDERTSKAQLYYSKLPPHIKDDVVLLLEPMLATGGSVVKAVESLTGFGVPEESIVLVNVVASKKGLDVVSTRFPELKIVSAAVDSELTAENYISPGVGDFGDRYYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8H7</accession>
    <name>A0A2I2G8H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_177262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704491.1">
        <property type="nucleotide sequence ID" value="XM_024842643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8H7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8H7"/>
    <dbReference type="GeneID" id="36550341"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_177262"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="599" mass="66135" checksum="B3EC1A51D838E226" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8W5</accession>
    <name>A0A2I2G8W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Alpha-galactosidase</fullName>
            <ecNumber evidence="6 12">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_384078</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="6 12"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704613.1">
        <property type="nucleotide sequence ID" value="XM_024845668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8W5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8W5"/>
    <dbReference type="GeneID" id="36553367"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384078"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014172562" description="Alpha-galactosidase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="17">
        <location>
            <begin position="56"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="16">
        <location>
            <begin position="666"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="381"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="501"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB49311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="744" mass="82272" checksum="937DECB16C9545F1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9B6</accession>
    <name>A0A2I2G9B6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_358179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704773.1">
        <property type="nucleotide sequence ID" value="XM_024844267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9B6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9B6"/>
    <dbReference type="GeneID" id="36551967"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358179"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="296"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB49471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="343" mass="38807" checksum="D2A64BB0E27EAFD2" modified="2018-02-28" version="1">MAISDLLNRRVRARPEDDEDDYSDEAPSETGVQNEGSEASDSENGSEDDSEGVDDLSDSANEDEADEDESEDDDDGNEDVRASLNNISFGALAKAQASMGSNSKRHSKPSKSTEEPSASSPLDDIRARILEAREQKRQALKDAEKKASRSSKHAPMVQSSKHAVSRKRTIVEPPSIPKSRDPRFDPTVMSSSSRSNSEAAEKAYGFLDEYRANELKALKEQLAKTKNVNEKEELKRTIRSTSDRLRAMENKKREKEVMADHKKREKQLISEGKKSNPYYMKKSDLKKQVLLKKYEDMNSKDRAKALERRRKKMASKERKEMPMERRGMGDGDDGEGRKRRRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9P3</accession>
    <name>A0A2I2G9P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_384693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704894.1">
        <property type="nucleotide sequence ID" value="XM_024845686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9P3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9P3"/>
    <dbReference type="GeneID" id="36553385"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384693"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="509" mass="56392" checksum="9BC3CC79C17D7B65" modified="2018-02-28" version="1">MAAAIKETVSNIVDKLSGHAEDAPRQPSTEEFQQLQQKYTDAGQGHLFAFVNELQPAEKTQLFHQLNNFNPTRINELADKALNPAKSQEGPVSLEPLPDVATASILDSDPKDIQKWYDEGLQFVAENKVAVVLMAGGQGTRLGSSAPKGCFNIELPSQKSLFQIQAERIAKLQQLAQKVSGKEAVIPWYVMTSGPTRKPTEEFFQKNQYFGLSSSNVVIFEQGVLPCISNEGKIMMESKSKVAVAPDGNGGIYQALLTSGVREDMRKRGIQHIHTYCVDNCLVKVADPVFIGFAASKDVDIATKVVRKRNATESVGLILQKNGKPDVVEYSEIDQETAEAKDPKQPDVLKFRAANIVNHYYSFRFFDSIETWAHKLPHHVARKKIPCILAETGEAFKPEKPNGVKLEQFVFDVFPLTPLEKFASIEVRREDEFSPLKNAKGTGEDDQDTSKRDIMKQGQRWIEKAGGVVVTEDESVGVEVSPLISYGGEGLEFLQGREIKAPAVIEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAM1</accession>
    <name>A0A2I2GAM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_454627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705226.1">
        <property type="nucleotide sequence ID" value="XM_024851457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAM1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAM1"/>
    <dbReference type="GeneID" id="36559156"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454627"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000710">
        <property type="entry name" value="Serine 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="266" mass="28776" checksum="6FF6A97A1E22636A" modified="2018-02-28" version="1">MSLKGSNVLITGASMGIGAAIAHAFAQEGANLILFARSEDKLQTLASTVQKQHPKSKVIYKAVDIQSYEVVESAVKSAVQELGEIDILINNAGLALGAPATFSDLKISDILAMNNTNINGLMFTTYAVLNASMMSRKFGTILNITSVTGLEVPPFPGESVYHCNKAAQEGFTNALRNELCGTNIRVLALRPGCVATNFHSLRVGHDKEKYEKFFEGYEPLVSEDIAGAAVYMVKQPENVSVKAMDIVPSAQRSLTVFDREWSERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBX4</accession>
    <name>A0A2I2GBX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_445706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705683.1">
        <property type="nucleotide sequence ID" value="XM_024850730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBX4"/>
    <dbReference type="GeneID" id="36558429"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445706"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="316" mass="35489" checksum="5C7F6D949AE23001" modified="2018-02-28" version="1">MEVPDTLKSANGGNPSEPRQFPLDGCDIYQVSNEALTALFNTAPVIHDYQGTRIVRLSKTLVLKGGNCTRPCEANILNLIAEARVRENPIIPVPQVHRVLNIEPEEIYGCKCLILMDYIEGRTVEKCWDSLSQAERVDIASQVASTISTLRSIPLSEQQQQQPGPVGCKSCVALGKWFVDIGAGPFDSKKDLEDWFNLRLIITKKFYQAPDTTPPFHFDRLVLTHSDIAPRNLILGTDGKVHLIDWGDAGIYPDGFEVASLKARRFEAPQYTDMLVEMLSRTIPMHEELYQQLRSIVFALTTGQWLGKEVLDYERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC39</accession>
    <name>A0A2I2GC39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_435648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705760.1">
        <property type="nucleotide sequence ID" value="XM_024848986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC39"/>
    <dbReference type="GeneID" id="36556685"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435648"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="96" mass="10169" checksum="6DFC1A335C986B7A" modified="2018-02-28" version="1">MSHFWASSSGRPGMLTHADLRNPPRASASVCLGSSAIAAPSPGFIPPASRRHASLIRGSPPWFVLRARNLVLGEASSDPAKQRVSPPAGRQLCTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC57</accession>
    <name>A0A2I2GC57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_405558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705766.1">
        <property type="nucleotide sequence ID" value="XM_024846590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC57"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC57"/>
    <dbReference type="GeneID" id="36554289"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405558"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="195"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="654"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="821" mass="90531" checksum="2FE6CBC7A3F5DE10" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCB9</accession>
    <name>A0A2I2GCB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_455027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705830.1">
        <property type="nucleotide sequence ID" value="XM_024851494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCB9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCB9"/>
    <dbReference type="GeneID" id="36559193"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455027"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000051">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="110"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="364"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="989" mass="110540" checksum="D239246346A89906" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCG8</accession>
    <name>A0A2I2GCG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptide hydrolase</fullName>
            <ecNumber evidence="18">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_445856</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="18"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705880.1">
        <property type="nucleotide sequence ID" value="XM_024850745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCG8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCG8"/>
    <dbReference type="GeneID" id="36558444"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445856"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000021">
        <property type="entry name" value="Myo-inositol-1(Or 4)-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 18" id="KW-0732">Signal</keyword>
    <keyword evidence="12 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013986221" description="Peptide hydrolase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="19">
        <location>
            <begin position="170"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB50578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="724" mass="78907" checksum="A18A753702D1C953" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCT7</accession>
    <name>A0A2I2GCT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_455119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705949.1">
        <property type="nucleotide sequence ID" value="XM_024851505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCT7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCT7"/>
    <dbReference type="GeneID" id="36559204"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455119"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="466" mass="50724" checksum="B94E56DC57CD5FA8" modified="2018-02-28" version="1">MSNAIRTLSPSTNKLIYEHPGTSLEEARQLAISAQDAHKSWKQVPLSERKSIILKALELIKANKETLAEELTSQMGRPIAFATKEIDTMRKRADYLLDIVDDSLKNLPGQPEDGFRRFLKKEPIGVVFIATAWNFPYLITISTILPALLAGNAVLLRPSPQTPLIGERFLSFFTEAGLPPHLFQLIHCGSLDVLDQIVALPQINLVSFTGSTAGGMRIREATARRVVPVNLELGGNDPAYVRPDADLAYVAAQLVDGAVFNSGQSCCSVERVYVHADVHDAFVHEVQKELATYKLGDPADQSTTTGPVISQQAVKTINAHIADALAKGAVDATPDNATFSAPPPDGNYVAPKVLVNVSHDMRTMREETFGPVMPIMKVASDDEAVALMNDTDFGLTASVWTKDVSAAEGLMDRLEAGTVFVNRCDYPSPDLAWIGWKNSGLGCTLGPHGFDAFYKLKSFHIKEQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCY0</accession>
    <name>A0A2I2GCY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_354009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705999.1">
        <property type="nucleotide sequence ID" value="XM_024844005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCY0"/>
    <dbReference type="GeneID" id="36551705"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354009"/>
    <dbReference type="OrthoDB" id="5389892at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29740" checksum="E202BE38E1C24F9A" modified="2018-02-28" version="1">MTSALSPLPHYSSSPRLDMTRHSQNPYYRFLSPSPSRHTLRRQRSSSVPSVYYNGMLEHFPMEQPRRRDYPTYHHHNHHNHHSHHHEPRRHSTMRSGRRQSRYPRDSLLVNPDIIDRLDDAGIYQYHHEGPYDAVYPERNHDTKASPVEALQTSNAEALKATPSDKIRDCLDGHRPLDGVAYFPPGHTDREGQTYEYEEGTNMMNDYGNFMRCPGLKFTDEDFKNDPFYNKPLPKPFASLRKVLNFRRRRGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD69</accession>
    <name>A0A2I2GD69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_446061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706148.1">
        <property type="nucleotide sequence ID" value="XM_024850759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD69"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD69"/>
    <dbReference type="GeneID" id="36558458"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446061"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="691" mass="73955" checksum="6CC57DC33EB97107" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE63</accession>
    <name>A0A2I2GE63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_425447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706490.1">
        <property type="nucleotide sequence ID" value="XM_024847633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE63"/>
    <dbReference type="GeneID" id="36555332"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425447"/>
    <dbReference type="OrthoDB" id="4524949at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="254" mass="28958" checksum="6F9E866E6EBB060D" modified="2018-02-28" version="1">MASRVLNTSQDGFNLLQAEIVPEEASRFPIRASEIFHSTSHRCVRPQYDPFDGLRVLVCFPSKKPLKNAPMLHWLQDLLRETLGSSKKITYDQFCYNVTDTGVGEQPFHSYRRHGGKVGAVQRIKKGLPEIQDMISDYHAVFFMSVESDIDTRDSPFFDKANIILFEYHSRYTAGVMSRGPSVQPELLELASAEKTYGKVLAEKFGIPPDDWHAIVCKDQKRLNSRTAFISDALNLLISRNQMENVFAFCLYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEJ5</accession>
    <name>A0A2I2GEJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_436353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706605.1">
        <property type="nucleotide sequence ID" value="XM_024849138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEJ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEJ5"/>
    <dbReference type="GeneID" id="36556837"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436353"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="91"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="227" mass="25987" checksum="833854CB05172E99" modified="2018-02-28" version="1">MSLKPIKLYWRNQVPNPSKVLVILEELGLPYETEFVELDALKQKPYTDVNPNGKVPAIYDPNQNLTLWESGAIVQYLITTYDTDHKISYAAAPESHHLLQWSFFQASGQGPYFGQSAWFNIFHEKFYGESPESAKVRYGNEVKRIAGVLDGVLAGRDWLVGDKCTYADLAFVMWNLQLPFFMSSRTGEHAWNPAEFPNFSRWQDAMMARESVKRVVAVLQDKEVKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEJ8</accession>
    <name>A0A2I2GEJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Exo-1,3-beta-glucanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_446391</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706584.1">
        <property type="nucleotide sequence ID" value="XM_024850786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEJ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEJ8"/>
    <dbReference type="GeneID" id="36558485"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446391"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014157403" description="glucan 1,3-beta-glucosidase" evidence="17">
        <location>
            <begin position="16"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="77"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB51282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="380" mass="41768" checksum="5C5E52AF0034AC38" modified="2018-02-28" version="1">MHILPLLSLLAPAAAEYLDWRTHTVHGVNLGGWLCQESTIDSTWWAANSLGAPDEWGLCANQGPACSSILERRYASFITTRDIDTLHAAGINTLRIPTTYAAWAKVPGSQLYSGNQLSFLRSLSSYAIARHGMHVIIDVHSLPGGVNGMPFGEAEGHYGWFHNDTALAYSLEVIDAVIDFVQTSEHPDGYSIAPINEPVDNTDMTAFGTPAALSDDGAAWTLQYLRAVIDKVEKVNRQIPVVVQGSFRPVSFWSGHFANTTNLVFDVHNYYFAGRRATGENITEYICEDAVASAGDGRFPTFVGEWSIEAEKGNTLAGRRRTLNTGLYAFGEHTRGSAYWTARFSGNATVDGEGRQRDYWNYMAYVQGDMIHPEEGRGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEN1</accession>
    <name>A0A2I2GEN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_407090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706599.1">
        <property type="nucleotide sequence ID" value="XM_024846667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEN1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEN1"/>
    <dbReference type="GeneID" id="36554366"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407090"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="584" mass="65684" checksum="0FE7A9B83938D883" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEN2</accession>
    <name>A0A2I2GEN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_464272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706657.1">
        <property type="nucleotide sequence ID" value="XM_024852232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEN2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEN2"/>
    <dbReference type="GeneID" id="36559930"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464272"/>
    <dbReference type="OrthoDB" id="4336792at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="368" mass="42041" checksum="E8C4DA89EEE519BE" modified="2018-02-28" version="1">MFENFISALVQDKLRDAISVLGAIESATKKRILVSWMPQGLRLDPCCVPSEDAPMTQNKVQTVEQNLALSRRVRSTRFKVGQMSRSVAPSLPSETFLGPSTTDDDEVSAHPTAALKAVGMRLSNPELIPTDQNHDSVYTMLLQLLALPLKTKEEVYQQSGDRMNAQRMRKKQHLLLDLSARRRYELRRFLDLEYWLRVVVQQEAVYLMQQQKIEKECGLGIEGEKADLRRKSIAKGLNWASKEYRLTRQSLHYFYCSTIDKPVTRAIRCLREDPKWHLSDFLRWDCADRGGCCSRACGCCERPRSTLNSLDLGHCTPACGCCAQYHGYRLKDFDTADTGRPRIDVMARRDDSFSGRMMDAHVWGLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF54</accession>
    <name>A0A2I2GF54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_349090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706808.1">
        <property type="nucleotide sequence ID" value="XM_024843718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF54"/>
    <dbReference type="GeneID" id="36551418"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349090"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000555">
        <property type="entry name" value="MFS transporter, putative (AFU_orthologue AFUA_8G05090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF15">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="441" mass="48029" checksum="C420AD855225DEDF" modified="2018-02-28" version="1">MEGKSEQNVSIQDPETQETEEQPPSNLPPTEKITHEVIGKILSTNFAYFMGGLNDAAVGVLIPYIQPAYHVNLLQVSLIYLVNFVGWITASFINIHVSSRLGTGGTLVVGAIVQCIGYALMCWFAPFPLFVIAFFFTGCGVGLQDAQANIFTVSLPNPHRWLGILHAIYGVGTVIAPLVANAMASTTSYWYRYYLVALGVGVINILFLAWAFRRGLFRPNVRNAKDTAGSELQATLSNGTVWLFNLFFFLYVGAEVTAGGWLVQFLVSVRNGDPEKVGYIATAYWAGLTLGRLTLADVTHRFGERRMVFIYIALAIALQIMFWLIPHIIANAVVICLLGYFIGPFYPVGLYVLTETVPANVQNGAIGFAASVGQAGSAAFPFLTGAIASKAGVFVLQPVMIALLVGICLLWGLINKETMLPAGRRLLALFSKDERERQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFK4</accession>
    <name>A0A2I2GFK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_471597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706970.1">
        <property type="nucleotide sequence ID" value="XM_024852858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFK4"/>
    <dbReference type="GeneID" id="36560556"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471597"/>
    <dbReference type="OrthoDB" id="4491784at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="46524" checksum="FDEA976F70D14668" modified="2018-02-28" version="1">MFATLRDLDSQSMVATEASTVPPPYNRPPHIVCQWCRSKKLKCSGFSTKGCARCRASNAECVPVSRSSRNAAVKRNQRIRPTGQDLTSPPDNLVRESSHCSPPFDIHSPSSEKHPSDGIASCPPIAQLESLPDSDPDCLEHLPYELHHSMTQEFLPPLPINWNLDGNKSSPESITLASSRDVNDQPGTQNLEASWKSFTDSIGEECGPRSDTSPCQCIHHALEMLDDFCGQEYTPGPACLGDNGFMLQRLATLRSGVRKLESLTACFRCRGAQRPMTLFVLLSERLVNHLLLTLETPIPDPVSAGLFASSVLIRRESNGVWPCVTPSTAFENSTDYPVDDRDNIMTLSCGTNSLDVTAETSSLLTLLRLTTLQQLRIVLSKLWDRAQMEQWGGHLKTLRHQQNQLRAMDVAMKAQLTVEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFU3</accession>
    <name>A0A2I2GFU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_433616</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707045.1">
        <property type="nucleotide sequence ID" value="XM_024848536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFU3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFU3"/>
    <dbReference type="GeneID" id="36556235"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433616"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="134"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB51743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="337" mass="36408" checksum="EE675BA5BC03669F" modified="2018-02-28" version="1">MGMKLRIRGPEGQSTVLLDDSATVGDLRNQVVNATGLTTYEVKYGYPDLKPLALDGLELGSSLQEHAINLHGEQLIVTRKGDDTLQDSGSSGGPPISVPSQSLAPTGPPSPAHKPQNTSDDAPEIASSEHAGTFILRIMPDDNSCLFRAVGTALMGGMDAMNELRSVVAQTIQERPDLYSEAVLDKRPDDYCRWIQNEDSWGGGIELSILSKHFDIEICSIDVQTLRVDRFNEGPPTRCILVYSGIHYDTIALSPSAPPFAHTDAPPEFDTKVFDSADGLVLEKALALCKILQGRHYYTDTAGFRIRCNTCGGIFTGEKGATQHAAQTGHYDFGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG49</accession>
    <name>A0A2I2GG49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_88817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707122.1">
        <property type="nucleotide sequence ID" value="XM_024855427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG49"/>
    <dbReference type="GeneID" id="36563134"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_88817"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="237" mass="26081" checksum="E632BAD2CFA860C1" modified="2018-02-28" version="1">MAGILTSRGLLLHPEKLRNAPVHYIRHSILFVFELDRDSIMGIPLRQLRLEAIFFGTMHIARFGSRIPVGSPGVRTQDSGLQESEEAGKVLCRFHHTLLGQSKTARPGGQHHLYVPGRKMAKVRPKVALAAQRSLLLFVQLEPRGGLSVASGGLVYVCSISRMFPFMTWVLLQAYGAGSLEQVQWLPPYNGHTEECHRGYQVLSEHSGPRPSSCVGLALGALTDPDAGASLRRESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG86</accession>
    <name>A0A2I2GG86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707197.1">
        <property type="nucleotide sequence ID" value="XM_024848576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG86"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG86"/>
    <dbReference type="GeneID" id="36556275"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433792"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="200" mass="22835" checksum="E6B2CB0EA1AF7472" modified="2018-02-28" version="1">MPSLRPSLRPLRFSPWKSPSRFYSSPKEPPRSRFRRLNDRLPSFLRSYTTPLLGAPGTHITSFLILHELTAIVPLFGLVAAFHYGNWFPDLTSSAAFEEGTRRFGRWLRKKGWVEDDAEMDMELLAKERKEGSVDYKDLTPPKDGERKGMRLVWEFATAYAVTKALLPLRLAASVWATPWFARAILGPVGGRLRALFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH06</accession>
    <name>A0A2I2GH06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidyl-prolyl isomerase CWC27</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peptidyl-prolyl isomerase cwc27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Rotamase CWC27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_433999</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707462.1">
        <property type="nucleotide sequence ID" value="XM_024848624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH06"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH06"/>
    <dbReference type="GeneID" id="36556323"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433999"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000034">
        <property type="entry name" value="Peptidyl-prolyl isomerase CWC27 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="20">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="201"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="513"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="530"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB52160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="569" mass="62344" checksum="A1F6223BD6057F4A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHE0</accession>
    <name>A0A2I2GHE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_462283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707598.1">
        <property type="nucleotide sequence ID" value="XM_024852091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHE0"/>
    <dbReference type="GeneID" id="36559789"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462283"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="285" mass="32314" checksum="359BD4A87D84F1C6" modified="2018-02-28" version="1">MSMMLSDNLAPQPMTDIFTGDTCIDRRQCHRTVPMKVLALGVGRTGTASLRIALERLGYLRCYHMMAASVENPPDCLMWHDALNAKYNGVGEFGRKEWDQLLGECQAVCDWPACAFAKELIEAYPNAKVILTTRDVDSWHASVMKTVFWRVSDPEHSFVSNFSWAAGMYYPMLNKFFQTFFRGDFPNKGKQVYEDHVAEIRSLVPPERLLEYQIGDGWGPLCEFLGEEVPDTPFPRGNDMADFFKRCRTRNRHQMLNAALQAVTMGGAILATGLAATMAFKRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHF6</accession>
    <name>A0A2I2GHF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_402382</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707613.1">
        <property type="nucleotide sequence ID" value="XM_024846421.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GHF6"/>
    <dbReference type="GeneID" id="36554120"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402382"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="10"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="947"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2472"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="947"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="979"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2557" mass="280464" checksum="0339B4120609B060" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHG0</accession>
    <name>A0A2I2GHG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_351579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707618.1">
        <property type="nucleotide sequence ID" value="XM_024843876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHG0"/>
    <dbReference type="GeneID" id="36551576"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351579"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="5"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="420" mass="46172" checksum="3540745535723810" modified="2018-02-28" version="1" fragment="single">ADFRVLPLLVLCFAIYQLERTNIASALTGGFADTISVNQNTINLGNQLMFLGVVVLEIPSNLILQRVGPRRWISVQVFIFGAVAALQVFVRDKTGFLLTRAILGLAESGFIPGAMYTLSTWYTREQLTKRIAIFFFGMFGGNAVSPLLGAGLLRLDGRGKLAGWQWIFLVEGILSMVVSIAIFFFLAERPNSTPETLSTDTGKDDGSEVNAHTQAISPKDVWNTLSNVRKWPHFLATACVFSTWSPLTTYTPSIIMSLGFSRIESNAIAAIGNFATLPVILFFAWLSDRTKSHGLIVMVAIAAYLIALVLLRTIQPHVGQWGRIGLWTTVNGLAVGYHPIHNAWIQINCKTPAERSIIVMTATSGLMAGTQIFRDDESSTLYPRGILIMIALAVAGLVLTAMQQFIYFLTNRQHKAEQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHJ1</accession>
    <name>A0A2I2GHJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707647.1">
        <property type="nucleotide sequence ID" value="XM_024852927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHJ1"/>
    <dbReference type="GeneID" id="36560625"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472245"/>
    <dbReference type="OrthoDB" id="4435532at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014122703" evidence="1">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="132" mass="15449" checksum="E42F07F86626D517" modified="2018-02-28" version="1">MKFIILCLFALLHLAAAAKSKWYNAGWPVGDKSWKPTDYTFARETGIDRYRLYDAGGRIYTYQLDIHVADGESGWLRTYVFEDSTADEYTINAFRDGEHSVSFNSEDAYILRVKDTETWYVDPLFVYAFYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHR4</accession>
    <name>A0A2I2GHR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_472313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707720.1">
        <property type="nucleotide sequence ID" value="XM_024852936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHR4"/>
    <dbReference type="GeneID" id="36560634"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472313"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="37892" checksum="D202A319D77BB58A" modified="2018-02-28" version="1">MPTQPPLPHLLAPYVSSPPQSSLTVLSSVLGATGNWLVLRYLYAALSTSSNSEAAFGLQGGDGGRKRKVVLVSFLRGWEFWRSEAKRLGLDLARLTDKRQFAFVDGLSELFNTPVTTPSQSTPSPFPGAAPSRTVLPVRSQPGPIPARGPQPVSRLPAQAPVPNGNATPTSKEIGPVKRLHLSGNGPTALGSLEREIAAVVRQLQAEASGDGEESEVLLIVDQPDLLLAATGPNRGIGATEMADWMMGLQQSAHATLMTVSADSPLIHNASAGSYELATPLETEHSAFVIGSAHRAQMVMQLRNLETGVARDVSGVLRVSKGGAWGRDDGAQGHWEEKEVLYFVQRDGGVNVFGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHX6</accession>
    <name>A0A2I2GHX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_104738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707749.1">
        <property type="nucleotide sequence ID" value="XM_024842285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHX6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHX6"/>
    <dbReference type="GeneID" id="36549980"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_104738"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014111486" description="WSC domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="229" mass="23581" checksum="0BB4B196E7CD74E6" modified="2018-02-28" version="1">MSRKILSIGLLSFLAFSPSIVSALQHDCYSNIGDLKQVMTSTYQSTGMCETFCNRSDYSVYGLKGDRCWCGDKLPPLSAKVSTKECNTACPGYPSDKCGGDGVWTIISDSSTHPEHSEAQSSSSEPKSSTKNYPMGTLSVNPTVVQTGAASQTSIPSNILTAPTMDPKNEMAEASALAATQASSSSSSSASSSADPESSSNVAVVPASPASVGSLVGAILLPLVLGSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHX8</accession>
    <name>A0A2I2GHX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_105610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707784.1">
        <property type="nucleotide sequence ID" value="XM_024842289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHX8"/>
    <dbReference type="GeneID" id="36549984"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_105610"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="129" mass="14805" checksum="98622FF0A80E6FEB" modified="2018-02-28" version="1">MWRSPDPPRSPLRKFVRSKESSYRSGSNGRWRRGRISPERRFVFLLLDVVAWPAYPSSLDTFASVCFSRFFFARQTSVLAGGCPIFTEAIRVPIRLQLVWRHKHQNDLIVSSAESHLEGKSTCMLCAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ97</accession>
    <name>A0A2I2GJ97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_434668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708252.1">
        <property type="nucleotide sequence ID" value="XM_024848764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ97"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ97"/>
    <dbReference type="GeneID" id="36556463"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434668"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="193" mass="20480" checksum="7AE14E05AAC26558" modified="2018-02-28" version="1">MSQINYRTINVDVLDPESSINFPMDTLLPPTLPAPTTSSDAAGVASQVRQLLRSGDPEGALHQVLETAPLGGDDRAKEVHLAAVIDVLQGIRQGEMMRVLEGVCTGDGGVERADCLMKYLYKGMSASGPSSGAQSPRKSVSPQSTGFSQIQGRNLGEGGGSQQMSVLLSWHEKLVELTGTGSIVRVMTDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJC4</accession>
    <name>A0A2I2GJC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_403690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708284.1">
        <property type="nucleotide sequence ID" value="XM_024846487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJC4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJC4"/>
    <dbReference type="GeneID" id="36554186"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403690"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB52982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="245" mass="27527" checksum="308BA8D7D3F5F42B" modified="2018-02-28" version="1">MGPVKNKYSVILPTYNERKNLPIICWLIERTFRENNLDWEVVIVDDGSPDGTLEVAKQLQKLWGPEHVNLKPRAGKLGLGTAYVHGLQYATGNYVIIMDADFSHHPKFIPTMIAIQKETDADIVTGTRYASRGDIKGGVYGWDLFRKFTSRTANLIADVMLMPGVSDLTGSFRLYKKSVLEKVISSTQSKGYSFQMEMMVRAKAMGFKVAECPITFVDRLYGESKLGGSEIVEYLKGVMSLWLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJE2</accession>
    <name>A0A2I2GJE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_352796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708269.1">
        <property type="nucleotide sequence ID" value="XM_024843939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJE2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJE2"/>
    <dbReference type="GeneID" id="36551639"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352796"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="42"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="425" mass="46787" checksum="5E10629DAB1DA42F" modified="2018-02-28" version="1">MLPPTPPVGIYPHMLPTPPPSPPITRCYAPEDRLGLLLANRLELTSILGVGAYGVVYTAVDIHTNVLYAVKALNKTGLDPRQLKYQQREIKLHHLASQHPNVVSLVRIMDSIDCTYVVIEFCPEGDLFSSITEKGNFIGNDPLVKRVFLQILDAVHFCHSVGIYHRDLKPENILVTDQGLTVKLADFGLATADPYTSDFGCGSTFYMSPECQQPNPRPMSWYESAPNDVWSLGVILVNLTCGRNPWKRASIEDSTFRAYLKDPLFLKTILPLSDEMICILSRIFECDPRKRITIPELRNLILDCPRFTTNPVTPWASVDGSLPGDCVNHPQVPEQIPVDVYNNPSSASSSDSSSQYSDSLESAVSGASSFTEGYPDLDSVSSMSSVGLDPEVDCKDDFPQADSVACSDLPEPLVVPQTFIPIPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJK6</accession>
    <name>A0A2I2GJK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_351585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708339.1">
        <property type="nucleotide sequence ID" value="XM_024843877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJK6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJK6"/>
    <dbReference type="GeneID" id="36551577"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351585"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="6">
        <location>
            <begin position="212"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="438" mass="49562" checksum="679BBE929E628F98" modified="2018-02-28" version="1">MNTTLPSWKDRTQNQFGKLQIQVPWRSIQLLVPHRMRRKIRSKLRSRISPTSSISSLQTSFSPVDTLRSLQSHRWTLYDFQYLLLLIVGIFSLSVIEAPGPLAKTAVFTLVLFSLLLPITRQFFLPFLPIAGWLVFFYACQFIPSDWRPAIWVRVLPALENILYGANISNILSAHQNVVLDVLAWLPYGICHYGAPFVCSLIMFVFGPPGTTPLFARTFGYISMLAVTIQLAFPCSPPWYENLYGLAPADYSMQGNPAGLARIDKLFGIDLYTSGFKQSPVVFGAFPSLHAADSTLAALFMSHVFPRLKPLFVTYTLWMWWATMYLSHHYAVDLVCGGLIATIAFYFAKTRFLPRVQSDKMFRWDYDYVEYGDSTREYGYDLAYDGEYNLDSDEWTVGSSSSISSGSLSPIDDHYTWEGETLASPASDIESGRHVISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJP6</accession>
    <name>A0A2I2GJP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Six-hairpin glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708379.1">
        <property type="nucleotide sequence ID" value="XM_024852997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJP6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJP6"/>
    <dbReference type="GeneID" id="36560695"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472954"/>
    <dbReference type="OrthoDB" id="3534988at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014182561" description="Six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="79794" checksum="5BB2A74909991270" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJS6</accession>
    <name>A0A2I2GJS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_434851</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708433.1">
        <property type="nucleotide sequence ID" value="XM_024848815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJS6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJS6"/>
    <dbReference type="GeneID" id="36556514"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434851"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000009">
        <property type="entry name" value="Vesicular-fusion protein sec18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="16">
        <location>
            <begin position="59"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="15">
        <location>
            <begin position="167"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="309"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="589"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB53131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="800" mass="87968" checksum="F7981D97A9B3C0ED" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJX7</accession>
    <name>A0A2I2GJX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_124532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708459.1">
        <property type="nucleotide sequence ID" value="XM_024842378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJX7"/>
    <dbReference type="GeneID" id="36550073"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_124532"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="91" mass="10420" checksum="8B0C98CA3C539BE2" modified="2018-02-28" version="1">MSWYLSAIGFLCACIRYKRERCQPHSGDSCGKKLGEFDNQKGTSRSSSPFTFFIYYLLCVVCWLIDVDRPRAKKKSKKESPTRGSNPQPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKD0</accession>
    <name>A0A2I2GKD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_445109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708636.1">
        <property type="nucleotide sequence ID" value="XM_024850679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKD0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKD0"/>
    <dbReference type="GeneID" id="36558378"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445109"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="61814" checksum="65DE272C0071CBBD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL22</accession>
    <name>A0A2I2GL22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine pyrophosphokinase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_376526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708867.1">
        <property type="nucleotide sequence ID" value="XM_024845373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL22"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL22"/>
    <dbReference type="GeneID" id="36553073"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376526"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF13">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="35748" checksum="5471B3E5CB4D10A2" modified="2018-02-28" version="1">MSPSYLDLVRQCDNFPYYEDSPQLYHDTKKHFYEFRVSDCDRLLGHIPTSVIDKVQWPECWIIDHSKKTATLGSGSPDTAAVRTRLLATTMHQMAQMNDFPILRGWRNETFPVYGPGGDVLLEIERSGSALFGIVTYGVQLTCYVEDEHGLRVWIGRRSRSKQTYPGMLDNTAAGGLGTGRLPGRAVIQEAVEEASLPTSVLTEGLQSAGCLSYYYIQGSHSGAADGLLQPEVEYVYELKLDPNTTPQPGDSEVEQFNLWSVDDVGNALRKGEFKPNSAIVLIDFFMRHGILTPENEPDFLEIVSRLHRRLEFPISTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLB9</accession>
    <name>A0A2I2GLB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative vitamin H transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_343796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708980.1">
        <property type="nucleotide sequence ID" value="XM_024843425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLB9"/>
    <dbReference type="GeneID" id="36551125"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343796"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="496" mass="55093" checksum="EC11ECADF230F74E" modified="2018-02-28" version="1">MAPTRSSVSKDDAESKIVLENLEHVSQEEQLLSLFPVLQDKTPEELERLNKAVVRKLDWRFLPCVTMMLLMSYLDRINVSNARLAGMQDDLHMTDTVWSAGISLFYVGYIISQVPANVLIAKGKPSIIFPSIMLAWSAVTICMPALSSGWGFCLCRFLVGLAEGPFIPAVSLLTSSWYTREESPLRMGIWHAGNTISNAFSGLLAAGILTNMDGIAGLRAWQWFILLEGIVSVIVGVLAFGFIPNFPDNTGRRWFTEEETAMAQYRQVLSAGGVREDDDGNHWGGVLLAIKDPFTWFFSAIHFSLIIAQSFKDFFPSIVGTLNFSEVVTYLVQAPPYFIAYLATLAISWSSGRMLEHCWHIVAPVVVALVGAVLMIATLNPGARYFGLVLLCTGPYVGLNIQIAWETTDVPRPRTKRAALIAIANCVSSVSHWFMPYFFLRSQEPRYETGGGIIIAGCGLAIISAVMTRWWCMRKNKQLDETEAESGNMTQWRFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLV1</accession>
    <name>A0A2I2GLV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_5515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709160.1">
        <property type="nucleotide sequence ID" value="XM_024855270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLV1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLV1"/>
    <dbReference type="GeneID" id="36562976"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_5515"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000611">
        <property type="entry name" value="Siderochrome-iron transporter MirC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF200">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB53858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="594" mass="64675" checksum="297A756ED690C26F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLW7</accession>
    <name>A0A2I2GLW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_345986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709183.1">
        <property type="nucleotide sequence ID" value="XM_024843534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLW7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLW7"/>
    <dbReference type="GeneID" id="36551234"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_345986"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014179713" evidence="3">
        <location>
            <begin position="19"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="184"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="665" mass="72407" checksum="D84DD682BB7C6612" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMN6</accession>
    <name>A0A2I2GMN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_451949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709411.1">
        <property type="nucleotide sequence ID" value="XM_024851238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMN6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMN6"/>
    <dbReference type="GeneID" id="36558937"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451949"/>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="46"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="146" mass="16323" checksum="61DAF0E0CBEF59C5" modified="2018-02-28" version="1">MSAYRQKGQAPLTPLEEGLDVRRQVLGTEYVNPAWNKASPFTRPGQQLITEYAWGNVWQRDGLDRKQRSLLTIGIIIAQKAWLELALHTRGAINNGVTELEIREAVIHSMVYCGTPAGVEAMMVTEKTILEMIKNGEYTRPEGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN25</accession>
    <name>A0A2I2GN25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709590.1">
        <property type="nucleotide sequence ID" value="XM_024848149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN25"/>
    <dbReference type="GeneID" id="36555848"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431917"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="1">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="167" mass="18716" checksum="6C426D7E1A960E5A" modified="2018-02-28" version="1">MRSSLLHVTPHPFSILPSHSSLDDTSSPRPPLREFLCSVLADATQFLGSIPDTFQSNREQCPSPPASAPVQVSSRIIRDSRPDSIPEKEFWYCRNSIHTDASVDGSASWKEFQEGLKTNHAENEMAYTPSVTAVDRVLEWPSEREIEGGWRDVDMQGMSPCLLSIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN45</accession>
    <name>A0A2I2GN45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_343599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709613.1">
        <property type="nucleotide sequence ID" value="XM_024843413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN45"/>
    <dbReference type="GeneID" id="36551113"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343599"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="49" mass="5835" checksum="406FD15CCEEEF1CE" modified="2018-02-28" version="1" fragment="single">NIFIDFIIYLFKSQNYNIILIIINRLTKIKYLISYNLTINIPAVAIIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN67</accession>
    <name>A0A2I2GN67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_469787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709615.1">
        <property type="nucleotide sequence ID" value="XM_024852676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN67"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN67"/>
    <dbReference type="GeneID" id="36560374"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469787"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16628">
        <property type="entry name" value="Mac_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="691" mass="76684" checksum="2BFF2A45C8277B03" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GND9</accession>
    <name>A0A2I2GND9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YCII-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_432040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709704.1">
        <property type="nucleotide sequence ID" value="XM_024848175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GND9"/>
    <dbReference type="GeneID" id="36555874"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432040"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="11717" checksum="CC0645BC211179B2" modified="2018-02-28" version="1">MAPLNEFLCIIPDKPGTLQKRLEVRPQHLEGIKPLVEAGQAVLGGAMLDSHPTEGQTPSFKGTAIMYLAESKEAAIELMKKDIYTVSGVWDVDNAQVIPFKSAVRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNE6</accession>
    <name>A0A2I2GNE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methionine aminopeptidase 2</fullName>
            <shortName evidence="13">MAP 2</shortName>
            <shortName evidence="13">MetAP 2</shortName>
            <ecNumber evidence="13">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_442514</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709713.1">
        <property type="nucleotide sequence ID" value="XM_024850467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNE6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNE6"/>
    <dbReference type="GeneID" id="36558166"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442514"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="16">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="825"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB54411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="861" mass="94412" checksum="744EC7416B3C8F52" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNI6</accession>
    <name>A0A2I2GNI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mg-dependent DNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_347454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709721.1">
        <property type="nucleotide sequence ID" value="XM_024843633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNI6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNI6"/>
    <dbReference type="GeneID" id="36551333"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347454"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000072">
        <property type="entry name" value="Hydrolase, TatD family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="315" mass="34880" checksum="20D3E61B83AF3FE3" modified="2018-02-28" version="1">MGDSSKPLRYVDIGINLSDPVFRGEYHGRQVHDNDLDDIIQRARDGGCEKFMVTGSDLEESRRAVELAQAYPGFCYATVGVHPCQAKLFDEYPEGASKMLEEVKTIALESKQAGHAVAFGEIGLDYDRLFLSPKEPQLKYFAAQLDLAVEIQLPLFLHSRAASEDFEQLLAPRLAKLPKRGLVHSFTGTLEEMNRMVAIGLDIGVNGCSLKTEENLEVVKAIPLDRIQIETDGPWCEIRPSHASAKYLEGATALPKAVKKERWQKGCMVKGRNEPVAISHVAHVIAKVKDITVEEVCEAAWNNSIRMFGLGEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNS1</accession>
    <name>A0A2I2GNS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_469993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709833.1">
        <property type="nucleotide sequence ID" value="XM_024852693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNS1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNS1"/>
    <dbReference type="GeneID" id="36560391"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469993"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="27"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="417" mass="47137" checksum="86BD0BD763863CE5" modified="2018-02-28" version="1">MFEKIPLAPSDPLLELKRVADSDSSPHKVNLGIGVYQNEQGQIYEPYCITMAKEKLALEDPDHDYTAATGIEEYLTHTAELVFGSNSEPLKSQRVASVQTIAGTGAIHLGALFLSKVATSPGQKVYVGTPTWGNHEPLFQLVKMQLDKYNHYDKALRKVDIESCLAALRRAPENSVFIFQVCCHNPTGADFSTPQWQLIADEMQRRNHVPMFDFAYQGLGEGENEDAYPIRLFAARGFEMLVCQSFSKNFGLYGERVGALHVVTKSREKAGCIFSQLRRLIRSEFSSSPAYGARLVNIILRDQTLRQAWAAELDQMRTRLKRNRLRLYESFLALETPGDWSHILHEKGLFSYLRLTPQQCHELTAHFNIYLVSDGRINVAGLNDSCIRRVARHIDLVVRDSLNAIPEEAIEHIESRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP09</accession>
    <name>A0A2I2GP09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_347641</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709912.1">
        <property type="nucleotide sequence ID" value="XM_024843644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP09"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP09"/>
    <dbReference type="GeneID" id="36551344"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347641"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000054">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="11">
        <location>
            <begin position="217"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="650"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="13">
        <location>
            <begin position="841"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="798"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="917"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB54610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1043" mass="112358" checksum="6A176F8D5E261AC3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPD7</accession>
    <name>A0A2I2GPD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_460790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710046.1">
        <property type="nucleotide sequence ID" value="XM_024851967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPD7"/>
    <dbReference type="GeneID" id="36559665"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460790"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014186597" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="35772" checksum="6474C6788C54FEC8" modified="2018-02-28" version="1">MLLSLTRIVCFVWAASALNIALAQTVIQSYPLSLISRFSSPQTFENIAVKSNGHLLLTSTTSPTVFEVSPFFENRNLPLVEIPQAQGLLGIVELEEDVFYVASSNITASRGTPGSNAVWRIDLRNATARSTGGEVSLVANITDAGTLNGMCRLGQSDRMLLVADSAKGQIFSLDVANGDYKVVMNETILQRTTDGLPVAVDGIRVHDSDVFFTNFNQGLFGRIPISPSSGTPTGTPEVTVANLSGDDFLLSDDGSRAWIAMNGNSTVVEVDILNKSSKVIVQSPLLASAAAIARGRSILDRDSLYVASGGCLSLKSNGSNVSCEGIVARIDVPSPGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPM3</accession>
    <name>A0A2I2GPM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_374204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710115.1">
        <property type="nucleotide sequence ID" value="XM_024845277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPM3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPM3"/>
    <dbReference type="GeneID" id="36552977"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374204"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00877">
        <property type="entry name" value="IDO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="433" mass="48241" checksum="6517AB479CC2EB43" modified="2018-02-28" version="1">MHISPAVTLDQYAVSLQSGFLPTIPPLQLLQDPYYWPWEDIVLDLPNHIKSRTIRQAVDALPVLSTSRLRDEPEWRRAYSLLAFLTHAYIWGGEQPEEILPPAISCPFLEVSNHLELPPCATYAALNLWNFSLKDRAADITDPDNLYINSSFTGTKDEEWFFMISVALEAKGATLIPLILDAIHAVSTDESQRLCDLLAQFSKGLSELRDLLERMYEKCAPAFFFHQLRPLLAGSKNMASAGLPNGVFYDEGHGHGEWHQHSGGSNAQSSLIQTLDIFLGVEHTATGDMKSNGVTKPAPKTGFLQEMRNYMPGPHRRFLEHLSQISNVRSYALSHKADSPVRDAYNTAVMALGRFRDSHVQMVTRYIILAAKTKHPDMQPKSAQVNLATTTTIQMKDLNEKVAGGLHGTGGTDLIPFLRKTRDTTKAAASYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ06</accession>
    <name>A0A2I2GQ06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_470386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710259.1">
        <property type="nucleotide sequence ID" value="XM_024852751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ06"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ06"/>
    <dbReference type="GeneID" id="36560449"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470386"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="722" mass="78992" checksum="273515DB609F77C9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ66</accession>
    <name>A0A2I2GQ66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_421646</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710325.1">
        <property type="nucleotide sequence ID" value="XM_024847379.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GQ66"/>
    <dbReference type="GeneID" id="36555078"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421646"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.690:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="926"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="809"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1074"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1278"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1314"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1099"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1283"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1314"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2005" mass="210414" checksum="A0F01C8F2C81FD6E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQV3</accession>
    <name>A0A2I2GQV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA transcription factor LreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_432791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710562.1">
        <property type="nucleotide sequence ID" value="XM_024848340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQV3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQV3"/>
    <dbReference type="GeneID" id="36556039"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432791"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="96"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47969" checksum="DA2F4B27CE1074E7" modified="2018-02-28" version="1">MAHNNQLSLVQGHMKDPYTTAPTAATTSTAATATTAAIITSPTTTLPIMASTAVSASTAAAREPRYLPPSHTEKFGAQNVDSDPSSDATKSVWTQRVLGEMKDMLLLLGSDGRIAYASPACHWITGYEFPQIDRHDIARFIHTEDRAFFAAEMDECIANSRPFHCHFRFYKRDNASCVLEAYGHPHMATPKRGSGSSNGRPTQVCNGVFLVCRPYPTRSSQTLDSFLEHKLENIRLNQRIAQLREEEEEDDINAGQQSAPGNQTTTTTTTHTMHSTFITSVQSSVTQSNVAEAAGSGDDSNDSSDEPTIGDESDSRSLLEQVEDRLPQTEDMSHIEGIEVMTGLYYGDGERSQGLSTGLRQGRLIHCNRESSSPESQEQDLPDSDRRKRLKGEYMCTDCGTADSPEWRKGPEGPKTLCNACGLRWAKKEKKRQDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSQ4</accession>
    <name>A0A2I2GSQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_433376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711206.1">
        <property type="nucleotide sequence ID" value="XM_024848472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSQ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSQ4"/>
    <dbReference type="GeneID" id="36556171"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433376"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="204" mass="21272" checksum="1C6DBE5BD729FD73" modified="2018-02-28" version="1">MSIWDSFSGRKQPKGPEFDASSAPDASSFFSDVAIPDPTQLHPLSGLNQDTLDYITLEDSALDELPGSRSVLPSRGWSDDLCYGAGTTYLAALTVGGAWGLAEGLNKTPATAPPKIRLNGVLNSVTRRGPFLGNSAGVVAMVYNGFNSGIGYARGKHDSANSIMAGALSGMLFKSTRGLKPMMISGGIVATIAGGWAVVRKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSR2</accession>
    <name>A0A2I2GSR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_471295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711202.1">
        <property type="nucleotide sequence ID" value="XM_024852827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSR2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSR2"/>
    <dbReference type="GeneID" id="36560525"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471295"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="767"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="834" mass="91149" checksum="40147410B8C71BF1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR90</accession>
    <name>A0A2I2FR90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_370046</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698433.1">
        <property type="nucleotide sequence ID" value="XM_024844939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR90"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR90"/>
    <dbReference type="GeneID" id="36552639"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370046"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB43131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="166" mass="18626" checksum="E6EB747BDAC3469B" modified="2018-02-28" version="1">MSSVAQKRLFHEYKNLSTNPPDGITAGPVTEDDMFYWEALIQGPEGTPFEGGVFAAELKFPKDYPLSPPTMKFVGGGVWHPNVYPNGTVCISILHPPGDDPNHYEHASERWSPIQSVEKILISVMSMLAEPNDESPANVEAAKMWRERRAEYERKVRDEVRKGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS96</accession>
    <name>A0A2I2FS96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_480476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698803.1">
        <property type="nucleotide sequence ID" value="XM_024853784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS96"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS96"/>
    <dbReference type="GeneID" id="36561482"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480476"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="202" mass="23202" checksum="D7789461D6B3B1EA" modified="2018-02-28" version="1">MHPYHEGNRYDDEGSRFLPIDGKKKLTPEERRTKRESFCPLSWVLTVIFGSLLILQNVYYLVQEPDCHLGSVYDTDFEPMKGAIETVQVRFTSPLYIDDNGTFHRQEDPGAIRYVGGPEEDLDANWASLLGGRYFRLNDNEVNTLNEDTELPHLSAWNQNGEELYFAGIDMLHSLHCLNALRKHLDPDFQDHTTAWSNSGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSR4</accession>
    <name>A0A2I2FSR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_459297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698953.1">
        <property type="nucleotide sequence ID" value="XM_024851859.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FSR4"/>
    <dbReference type="GeneID" id="36559557"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459297"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="917"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="917"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="966"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB43651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2478" mass="272511" checksum="B6CF49A36B5DFD17" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FST9</accession>
    <name>A0A2I2FST9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_514036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699005.1">
        <property type="nucleotide sequence ID" value="XM_024855166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FST9"/>
    <dbReference type="GeneID" id="36562872"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514036"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF52">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="498" mass="55482" checksum="BE8A8E38F3551E5B" modified="2018-02-28" version="1">MPTNPNPNTTSDPEKDPPRSETIEDIAVKPSQPESPIDPRAEKRLLWKCDLHVVPILTLLFMFAFLDRINIGNARLMGLEKDLGMSGHQYNVALFVFFIPYILFEVPSNMLLKRMRPSWWLSGIICGWGIVTICQGVTGSFAGLVVCRVIIGLLEAGFMPGCVYLINMYYRRHELQWRLNVFFSASICAGAVSGLLAYAINNMDGLAGYSGWRWIFIIEGLATVVLAVIAKFIIVDWPESATFLTEDERALLIRRLAEDQGEARMNRLDRKSLKRTFSDPKVYLGPIMYFGIVNTGYAVSFFAPTILHQMGWTAVRAQVMSIPIYAIAMVTTLTAAWVSDRLRHRYAFTLAGCLVATTGYVILLCQGSVPVGARYFALVAITGGGYLTQPILMGWLSNNMAGHYKQSVASAMQIGFGNCGGLVASNIFYQEEAPAYTTGYGVSLGMTWICGAACAVFLIYLVRENRVRENGGRDYRLRLPREELENLGDGYPAFRFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSW3</accession>
    <name>A0A2I2FSW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_441182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699027.1">
        <property type="nucleotide sequence ID" value="XM_024850258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSW3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSW3"/>
    <dbReference type="GeneID" id="36557957"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441182"/>
    <dbReference type="OrthoDB" id="5430812at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="590" mass="66754" checksum="67E1EE498674ADF6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU16</accession>
    <name>A0A2I2FU16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_430050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699437.1">
        <property type="nucleotide sequence ID" value="XM_024847924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU16"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU16"/>
    <dbReference type="GeneID" id="36555623"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430050"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="496" mass="54394" checksum="B8AA551BAE77A007" modified="2018-02-28" version="1">MGEVGPTALDGIPVRSIPQPASPASDLQSEVEDQWLSLICILQGLQCATTPGLDEPIIQKSTDQDISDLRLLSTPDIPRSISKVIQEAYAIFDHRARTNHPRFFSFTPANATPLTWLGDVIVSAFNAHCGGSLAAAGPCAVESELINWFASRIHFPSTAGGLFVSGASMANMMAMTAARDAKLEWHNHSKGVIYIARHAHNSLYKAARTLGFHAKQIRPVDLDASNRLSTSHLQQLIQSDRQKGLIPFLVIATFGYTETGLVDPLTIISEIARAESLWLHIDGAYGASLSLSISRSGLARHLSTADSVSWDAHKLLFQTYGCGMLLVRDKTHLVSSFHAQSSFLDHTARVQDEPEFWDMGVELTRPARAMSLWFTLRVLGTERIGQLIDHGMGLAEVIQIRLEAMEGWEIITPASLGIITFRYHPKQRQEERLDKLNEAISKVLLDTNTAAIMTVRVGGVLALRICCSNVRLTEDDVEELVGSVDELAILVNASME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV22</accession>
    <name>A0A2I2FV22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroneopterin aldolase</fullName>
            <ecNumber evidence="4">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_430315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699718.1">
        <property type="nucleotide sequence ID" value="XM_024847944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV22"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV22"/>
    <dbReference type="GeneID" id="36555643"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430315"/>
    <dbReference type="OrthoDB" id="5425486at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="8">
        <location>
            <begin position="191"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="302" mass="33596" checksum="E75F38DEA5A44EB2" modified="2018-02-28" version="1">MGECKSTFQIPLAPPLVDHICLRNVQLPLPCAPEAWHRPCLPQPCTMSLRLSCCSIMASAADDDVSQSLDYGKLYRRIEELVRHWPIVHAGYPSPILQWCRALPSVDPGQDIASLAGRIASLALGYLKETAREIHANRPGAIQQEFGQCEVDLHLPKALLRAEQGLWYRCHASLGRSPEGAEAAVVTGEEFRIRNIRCHCLIGINPHERLEKQVVVVSLKFQSPGAHFLDMYQEMTRVVAEEVDQTAFQSVEALVTFVARIVTVRFGNDVVTVRVEKPNALAFAEGTGVEVTRSRSFFTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVI3</accession>
    <name>A0A2I2FVI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_440873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699923.1">
        <property type="nucleotide sequence ID" value="XM_024850177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVI3"/>
    <dbReference type="GeneID" id="36557876"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440873"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000018">
        <property type="entry name" value="Heme/steroid binding domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="89"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="260" mass="29607" checksum="CBEB5EF5E4F3FC7E" modified="2018-02-28" version="1">MSDLRQRNTKSAKPKAQNDSPAPRRRNEAATKSGGIGVLDLLRLVITLAVASCGLSYYMTSSESLLWGYRPWFTRLPVLTRYLQGPLYLTPAQLAPHDGSDPSLPIYLAVNGSIFDVSANPMIYGPGGHYNFFAGRDATRAFVTGCFQEDQTPDMTGVEEMFIPIENDEEDAKTLSSGEKKTRREQELRQARSQVQKQVQHWENFFRNHKKYFEVGKVVGLEDLPKEKRELCEAARQQRPKRKNLNKKKQEQQKKQKQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVW5</accession>
    <name>A0A2I2FVW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_429522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700073.1">
        <property type="nucleotide sequence ID" value="XM_024847895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVW5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVW5"/>
    <dbReference type="GeneID" id="36555594"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429522"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="490"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="728" mass="79669" checksum="E66547894718A7AA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWR2</accession>
    <name>A0A2I2FWR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_366521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700383.1">
        <property type="nucleotide sequence ID" value="XM_024844762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWR2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWR2"/>
    <dbReference type="GeneID" id="36552462"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366521"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="312" mass="33212" checksum="E2EB9F09F750768E" modified="2018-02-28" version="1">MGGKSATKAAYFEKLKSLLDQYSTVFIVGVDNVSSQQMHEIRLSLRGEAVVLMGKNTMVRRAIKGFVTDNPEYERLLPHVKGNVGFIFTNGDLKATKEKILANRVAAPARAGAFAPGDVWIPAGNTGMEPGKTSFFQALGVPTKIARGTIEIVSDLKLIEAGTKVGPSEASLLNLLNISPFTYGMTIQQVYQEGQTFSAAVLDIEESQLLDAFSNAIQTITAISLATNFPTLPAVMHSVVNSYKKVLAIAIETEISWPEIEELKDRIANPDAYAAAAPAAAAAPAAGGDAAPAAKEEEEEESDGDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWX5</accession>
    <name>A0A2I2FWX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_429827</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700430.1">
        <property type="nucleotide sequence ID" value="XM_024847918.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FWX5"/>
    <dbReference type="GeneID" id="36555617"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429827"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000180">
        <property type="entry name" value="Related to UDP-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000110">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="963"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1454"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1679" mass="185893" checksum="F4905443BBE1FF77" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX37</accession>
    <name>A0A2I2FX37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_440312</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700474.1">
        <property type="nucleotide sequence ID" value="XM_024850046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX37"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX37"/>
    <dbReference type="GeneID" id="36557745"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440312"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="323"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="666"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="97"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="837"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="907" mass="101580" checksum="CF7B6A38340076F2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXG5</accession>
    <name>A0A2I2FXG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_367152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700609.1">
        <property type="nucleotide sequence ID" value="XM_024844793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXG5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXG5"/>
    <dbReference type="GeneID" id="36552493"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367152"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="371" mass="40367" checksum="76B05204286A5EA6" modified="2018-02-28" version="1">MASVDFPPAPTNTIDWSNVGFKVRDVNGHVECHFSRSNGNEWTAPKFVRSPHLPIHGMAPGLNYGQQAYEGLKAFRHANGSISIFRPDRNARRMRHSAEFVSMPAVPEDLFVRCVALAVAANAEFVPPHETGAAMYIRPLLFGSSAQLGLSPPDEYTFVVFVMPTGVYHGVHAVDALILEDFDRAAPEGTGSAKVGGNYAPVLRHSGRAAAEGFGITLHLDSRTRSEIDEFSTSAFIGVRKDPISGSVTLVQPDSKNVIDSVTAESVCEIGRRVFGFAVERRRIAYEEIKDFSEVVAAGTAAALVPIRSITMRSRKDKFTFDCGADGQSGGDICVKLLQTLKGVQAGKVEDQFGWNLTVQELPQDWLEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXU7</accession>
    <name>A0A2I2FXU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700750.1">
        <property type="nucleotide sequence ID" value="XM_024849789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXU7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXU7"/>
    <dbReference type="GeneID" id="36557488"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439211"/>
    <dbReference type="OrthoDB" id="3903581at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="854" mass="96541" checksum="3BAE523513F5CD71" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYD7</accession>
    <name>A0A2I2FYD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_248571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700957.1">
        <property type="nucleotide sequence ID" value="XM_024843009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYD7"/>
    <dbReference type="GeneID" id="36550708"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_248571"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="110" mass="12000" checksum="5CAC1C1C610C3C94" modified="2018-02-28" version="1">MPLGLSPKGRDRVSVSALSKQERPLAPGTVPLEKFHRIPRGLSYPPPLRPLAWLPKWSCCDDKVPLTGDSVSLLCLSLVLSLSIPVGTENGLLRIGSFFWLCFSADGRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZE0</accession>
    <name>A0A2I2FZE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_478920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701296.1">
        <property type="nucleotide sequence ID" value="XM_024853605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZE0"/>
    <dbReference type="GeneID" id="36561303"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478920"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="102"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="344"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB45994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114594" checksum="8F97C95800F48A5E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZH3</accession>
    <name>A0A2I2FZH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear pore complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701268.1">
        <property type="nucleotide sequence ID" value="XM_024849887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZH3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZH3"/>
    <dbReference type="GeneID" id="36557586"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439665"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="268" mass="28413" checksum="53D11ECD8EFDA1FE" modified="2018-02-28" version="1">MASSPLPSTPRAVSAPTPTADQSRTPGKWRHPQLDEIVRRQNARTFGDQNIRSIVWNTIALVAVRAYGDTVQSYSSSLLSTLEPSAFFNFLRVAVQLLFLSNIALALSPLVRSKDDLSDIPLTPTQRSLLGLDPSTTSPLTPGSTYITPPKYRLSASRTASSASKAASPLSASTSPSGRRLSSGASFSPSPSPLFHKAVSNGGRDNGRRPSFGSSTSFGRSSLFGESTMSSIAPATPSPVGGKRVSLGLSNKWLYERSRRLSASNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZJ2</accession>
    <name>A0A2I2FZJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable electron transfer flavoprotein subunit alpha, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_458230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701359.1">
        <property type="nucleotide sequence ID" value="XM_024851777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZJ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZJ2"/>
    <dbReference type="GeneID" id="36559476"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458230"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="12">
        <location>
            <begin position="420"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB46057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="733" mass="78460" checksum="1537D65229CD8251" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G081</accession>
    <name>A0A2I2G081_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_512780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701538.1">
        <property type="nucleotide sequence ID" value="XM_024855023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G081"/>
    <dbReference type="STRING" id="1392250.A0A2I2G081"/>
    <dbReference type="GeneID" id="36562729"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512780"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="614"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="707" mass="79991" checksum="7CBC4C705EA9E125" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0D2</accession>
    <name>A0A2I2G0D2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_477216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701639.1">
        <property type="nucleotide sequence ID" value="XM_024853425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0D2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0D2"/>
    <dbReference type="GeneID" id="36561123"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477216"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="363" mass="38841" checksum="C6329C8CB38AA5A0" modified="2018-02-28" version="1">MAPTKLLLTGATGYIGGTVLTQLLDSASPEIKKLAISVLIRKKDQAAIYASKGVTPLIFNGLEATEDLRDIASGHDIIIHAADSTSPAAVEALILGLASSQEVSKPKYLLHVSGTSSLGDRPITKQIQEPTVFSDKEDIYSYLKEREAIDPYPQRATDIKTVEVGERAGINTLVVKAPLIYGRGTGLFNRKSFHIPALIQGAVAAGNAEHIGEGTGVWDYVHVVDLAGLFELLVVHILRGGGLSTGRTGIYFAETQRHSWKDLADAIAKAGYSLGRLTSPVSKSISLQEAADKYTGGDESLAEVGLASKYEPPIKLFVTRADAFFLSSLTSAQLGRELGWKPEVGIELQQAVLDDFTLLFGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0H6</accession>
    <name>A0A2I2G0H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_363647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701671.1">
        <property type="nucleotide sequence ID" value="XM_024844592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0H6"/>
    <dbReference type="GeneID" id="36552292"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363647"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="365" mass="40512" checksum="D8E68E081C42ED66" modified="2018-02-28" version="1">MGRFSPDSWTPAVNVLTWYLLVTAVLSLLTRLGTKWWIFRKLTTDDYWSVVSLISCAGQSIAVSMATANGYGEPYDTVSDSSMQNIMKAQYAANILFIISMCFSKLALIRFVRDLTPATSDRRFAVYLQVLTSLWALVGIITAAFQCKPPRTWDYMEGQCFRIDAWWDYLGVSNILTDMGIIVQAILVVARIQTNVKKKMTLGSVFALRIFVIVAILCQIIYARQTANSTNITSDTWPVAISTQLAQCFSIVTACSPQFKPFMDSLRSTGMRIDGMTRYGTSQKGYGSQSASRAATLHSRSRRRSEVHELVPLPAKDSHHQATVTTAGGAGDWDAESQTSQSRIIREVRTWTVTDAPRSSGGDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G176</accession>
    <name>A0A2I2G176_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_457172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701934.1">
        <property type="nucleotide sequence ID" value="XM_024851697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G176"/>
    <dbReference type="STRING" id="1392250.A0A2I2G176"/>
    <dbReference type="GeneID" id="36559396"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457172"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27943" checksum="DC5C4EF20D426338" modified="2018-02-28" version="1">MRWTIVNAIFFTLGLFFWFSPLSKQLALRRLNDQDKWKATSVYLPLLDRLDIPKTTFTSNSTFYDHEPLPILRVPTGPEADAEWDRIGGSTKARPIVVSSAEIHRIGKDPSKAVKIPEKFGYGSDAYIAWTEVFHLLHCVDILRQHVYSDHYGSGHGGESHLDHHSHASHCLEVLAESIKCSGSVDPILFVWVEGAGMPSPEFANKHLCRDFETVLEYVNKNGIPKEVFNEMKEPPPGYVPIPEFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1H6</accession>
    <name>A0A2I2G1H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_466129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702008.1">
        <property type="nucleotide sequence ID" value="XM_024852389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1H6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1H6"/>
    <dbReference type="GeneID" id="36560087"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466129"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="203" mass="24140" checksum="3C582A87E01A15C2" modified="2018-02-28" version="1">MGALKYVEEIQKKKQSDVIRFLLRVRCWELRQLNAIHRASRPSRPDKARRLGYKAKQGYVVYRIRVRRGGRKRPVPKGATYGKPTNMGVNQLKYQRALRATAEERVGRRCANLRVLNSYWINQDSTYKYFEVILVDPQHKAIRRDARINWIAKPVHKHREARGLTATGKKSRGINKGHRYNNTKAGRRHTWKRQNTQSYWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G273</accession>
    <name>A0A2I2G273_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_229062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702268.1">
        <property type="nucleotide sequence ID" value="XM_024842890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G273"/>
    <dbReference type="STRING" id="1392250.A0A2I2G273"/>
    <dbReference type="GeneID" id="36550589"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_229062"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="576" mass="63510" checksum="FE0F16CC79EC48C9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2B0</accession>
    <name>A0A2I2G2B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_457421</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702324.1">
        <property type="nucleotide sequence ID" value="XM_024851718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2B0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2B0"/>
    <dbReference type="GeneID" id="36559417"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457421"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="116"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB47022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="392" mass="44291" checksum="26064421DD61F342" modified="2018-02-28" version="1">MSTKTLEARLEHLSVKDENESGNNVGGYTKHKSSFSTAASLAGLGTSAPLNNASNRSNLLKLALQNTNDNKVNAMNVGSSPTKANLPQRNVDENGDQRHAALYEQPSPKKLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPGSQDNFYSEKVDLWSLGVLTYEFLVGEAPFEDTPVMTQRRIARADMSVPSFVSSEAKDLIKRLLVLEPEKRISLDEIQRHPWILKHCIKEEKTMKRGSGLSKDGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2R0</accession>
    <name>A0A2I2G2R0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cwf15/Cwc15 cell cycle control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_438869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702458.1">
        <property type="nucleotide sequence ID" value="XM_024849703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2R0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2R0"/>
    <dbReference type="GeneID" id="36557402"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438869"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="234" mass="26876" checksum="04E1072CAB3A1C6C" modified="2018-02-28" version="1">MTTAHRPTFDPAQGKEALRGPAYHQRLLPAHTHLKTRQLGQGSENESQQRDLRAELLQAEAAHFAKKNGVPVDAPALENAAPKRQLEGAPASGEEGTKEEDPEAKRRRILEETRDIDADSDGSEEDSSEDDSDDDEDEATELMRELEKIKKERQQQKEKEEQERAAEEEEQREVDIARGNPLLNSQDFNLKRRWDDDVVFKNQARGTENRGDKEFVNDLLRSDFHKRFMSKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2U1</accession>
    <name>A0A2I2G2U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_457550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702493.1">
        <property type="nucleotide sequence ID" value="XM_024851726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2U1"/>
    <dbReference type="GeneID" id="36559425"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457550"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB47191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="476" mass="52315" checksum="293B6A249E78B595" modified="2018-02-28" version="1">MTGQQPSVSVSSTTTQSEKKVWYHSTLFNAFIIGGVGFMAPGLWNAMNSLGAGGAQSPYLINAANALVFGLMGFLCLFGGPIANRIGLNWTLLLGAVGYPIYSAALYTNNRYGNVWFVLVGSVACGLSAGLFWASEGAVALGYPEPSKRGRYMNIWLWFRTGGPLVGGAILLALNHSADAKSKGKVGSQSYLIFVALQCLATPLAIFLSPPEKVQRSDGSKVKIVVQESWRAELRELWKLSCRKEVAMMLPMFWAAYFNQYSSNFQAYYFGVRARALIGFVSNFSNLLSSGIISRFLDYKGLSVKKRITYGFYYVVVIHIIAWVYAWVVQEKYTANPPSYDWTDKGFVEGFFVLILWGFTQQALQNLLYYLLSTMTDNISELSRLSGILRGQESFAQAISFGINTRNWHGGRVPLAVNTILLGIAVFPTWLVVKNHTPIEHDKVAPSAVQDEEQGVQDGTVEASGKGGYVVGETTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G300</accession>
    <name>A0A2I2G300_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_237231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702551.1">
        <property type="nucleotide sequence ID" value="XM_024842931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G300"/>
    <dbReference type="GeneID" id="36550630"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_237231"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="135" mass="15754" checksum="4397AED4DE65FBB0" modified="2018-02-28" version="1">MRRRSHCDPARKDRRKERGGGGIRRPGQIPHARHEESEGRETKHRMDPREKRKQEEEEEREGEKEEGASDGEAKVETWRNSRLSQAFRPWRGTAWYRVRQWPVQRLTMQGRVTSLPSAFFDGCSAPFAGPPDMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G386</accession>
    <name>A0A2I2G386_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_362996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702619.1">
        <property type="nucleotide sequence ID" value="XM_024844547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G386"/>
    <dbReference type="STRING" id="1392250.A0A2I2G386"/>
    <dbReference type="GeneID" id="36552247"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362996"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="833" mass="92479" checksum="60EB712505B3DB3A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3F6</accession>
    <name>A0A2I2G3F6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702713.1">
        <property type="nucleotide sequence ID" value="XM_024849756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3F6"/>
    <dbReference type="GeneID" id="36557455"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439077"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="48870" checksum="21B91F0E374F7CE8" modified="2018-02-28" version="1">MGWLQVAENRWERPSNGMEGYFVLSGGLSASLCQGREHYIISSRLKVDLKLSDAEASLRQAWTQLRHEQPQIATRVEGMNKVYEVPDETALQAWLAETFIVSSAADADELYRGVGPIRSATLYYVPRSSELVLRAHHHTLDGVGMLLLCHSYLSALASPRTVSFGDEPARLPPPLEEALGDPELPRQAIAEKGRALATEFIDGLPGLGPVSQVGKVPAGAAQFAERVFPARTSAAVVQACKQKGLSVTAALHAAYVRAIAKYADPEGSSRYVTVSQFNFRPFLREPYGTSQYAAAMYYSILPVLLEKPTEFEELAQTLDSFYKSGYKETDDREASGSLTRTLQEIVQTPEFLTKPVSRDALVSSLGVAERHLQQSYGEVATVQDLRVGVDIILGMSMILFYTFRDQLRLVYSFNDAYEDRSQIERYLDEMQRILLEELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G447</accession>
    <name>A0A2I2G447_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-acyl dihydroxyacetone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_409859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702943.1">
        <property type="nucleotide sequence ID" value="XM_024846816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G447"/>
    <dbReference type="STRING" id="1392250.A0A2I2G447"/>
    <dbReference type="GeneID" id="36554515"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409859"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="289" mass="31790" checksum="D33FCBA5E1844666" modified="2018-02-28" version="1">MAKTIPFALITGCSSGIGKELAIAFAARGITVLATARRVESLNDLTSKYSNIEALSLELGNPNGDAESIAKLKEAVSKRTGGRLDFLVNNAGTHYASTTLDVEIKEVETLFQVNVFAVMQLCQTFMPLLRRSPRGRIVQIGSVTRDVPVVWQGAYNASKAALSQYSKTLRLELRPFGIEVVEIVTGFVRSNLLHHGFYAPETSLYLPVKKTIEDIKYQGNADGMPPAAYARAVVEQVTKPGTISSEIWEGGMARLIRFLVLVLPLTILNLIYYRKFKLNLLEGRGNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4A9</accession>
    <name>A0A2I2G4A9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactosyl transferase GMA12/MNN10 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_437452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702995.1">
        <property type="nucleotide sequence ID" value="XM_024849369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4A9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4A9"/>
    <dbReference type="GeneID" id="36557068"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437452"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35250" checksum="6FE52D609079BD4E" modified="2018-02-28" version="1">MKQARYPVRNRRRRLKAAAPLILALLGIFSLLRLFSIYPNHHAQEIEPPQPVVGKVSMIYGNHSIYERGLETHREHSRRHGYPLIVLRRPILDGVWNKYAILLSALLEELQKPPHKRLQWLFWADGDTVLMNPNIPLEIFLPPPHIKDVHMLLTKDWNGMNNGVFPIRVHPWSVELLSSAIAYPRLHPEVDLYWPDQSALQNVLDGSPYFSSSVVYCPLRWFNAYMGKPDGSGLNPDSPKYLQIHPGDLLVHFPGTPPDHLNTTIGPYLDIAESHRAHWELPLESTGYVEETRRFWEDFRPSPLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4I0</accession>
    <name>A0A2I2G4I0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_197654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703083.1">
        <property type="nucleotide sequence ID" value="XM_024842742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4I0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4I0"/>
    <dbReference type="GeneID" id="36550440"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_197654"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="222"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="449"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="772" mass="86948" checksum="9A72AB6E0816E23A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4W2</accession>
    <name>A0A2I2G4W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_510621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703214.1">
        <property type="nucleotide sequence ID" value="XM_024854796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4W2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4W2"/>
    <dbReference type="GeneID" id="36562502"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510621"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="56"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB47912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="227" mass="25539" checksum="819D28FEE4653C43" modified="2018-02-28" version="1">MGSENPSNPLWTTQSVLSTLPHPPEENSASPIPFFHLLERLKTTKREGWRRFGINSGESISDHMYRMSIMTMMAPPALATQLNLPHCMKMALIHDMAESLVGDITPVDKVDKSEKARREADVMNYISKNLLGGVPGGMLTGQDVLSVFQEYEDNVTLEAKYVHDIDKMELLLQMVEYERTHGLDLSEFCHVAGRVQLPEIKEWAATVLQEREALWKSKAEKDGQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5W7</accession>
    <name>A0A2I2G5W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">P170DRAFT_437948</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5W7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437948"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="429" mass="47315" checksum="D3C62D1DFAFAE757" modified="2018-02-28" version="1">MSIDVNWGTATSGPDGEALAERIRSFIHDRFQQVALPRFIRSVQVHSFDFGTIPPDLEIKDFCEPFADFYEEDEDDETSEVSEEYVSDHGNQWHGHSDLNDSSFRDELTMNHTLRDPFDDDYQPSVLRSPMPLSDHLNPHFLPRAGTPGIPGGTSTLGYHLMSIGGLSGTQTPLAAVAGGTPFASGWGDPGMRPGNIHHPSTPTRVRPDADIDSSNPASRPSTSSTHPSHPSGSQRNSGDSTMGKGNGSHRDDQHDGAQGDPLRLPPRMRERKPEDFQVMCHAKYAGDIRLSLTAEILLDYPMPSFVGLPLKLNVTGLTFDGVAVIAYIRKRVHFCFLSAEDADALIGSDQQETGDQSDHSRSGADPSTSPKRQGGLLREIRVESEIGRKEDGKQVLKNVGKVERFVLAQVRRIFEEELVFPSFWTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G612</accession>
    <name>A0A2I2G612_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_456877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703617.1">
        <property type="nucleotide sequence ID" value="XM_024851658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G612"/>
    <dbReference type="STRING" id="1392250.A0A2I2G612"/>
    <dbReference type="GeneID" id="36559357"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456877"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="580" mass="63041" checksum="5E787CF9E59D2069" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6D2</accession>
    <name>A0A2I2G6D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_456945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703739.1">
        <property type="nucleotide sequence ID" value="XM_024851667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6D2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6D2"/>
    <dbReference type="GeneID" id="36559366"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456945"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="11">
        <location>
            <begin position="284"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="440" mass="50505" checksum="8744625156788F01" modified="2018-02-28" version="1">MTMAVYNTVLRRWPSLIFLDPQEDSPEELAPLDLPSEYSETPDETTFCAERFSPKYLEDLRDSSTEYCTTNSTSQMTCFHSTTTPDRVDTFCLGRDVLYDASSKKFHLESYGEFHDYWYRTGPSTVIYNWVDVQNTTLNSTKPINETDFTILVKREGSHNLWHSMMELFSMTMTMDVLQMSRAENETQPFWTPSDAKNTQVVLLDDNDDGPYIDLWSLFAEKPTVRLTDLPESSTLENIIVPLAGGSNPLWQGDWEIHPCEDSRLLRTFSRRVLDSYGIGDSAPRQGPEITLTFINRTDTRQLVHDTSYLEEVEAKYPHVKVQSIDFAAIPFKDQLRIIQETDILVGVHGAGLTHGMFLPVRSTMVEILPSALNHKGFRNVAGLLDHSYFSIHASTKQSARKRNDWHGDDVFLEKDRFMKIIDVAIKGMYNRGERNYDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6L3</accession>
    <name>A0A2I2G6L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1365-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_360714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703812.1">
        <property type="nucleotide sequence ID" value="XM_024844429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6L3"/>
    <dbReference type="GeneID" id="36552129"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360714"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="72301" checksum="0049B125A39437AE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6L5</accession>
    <name>A0A2I2G6L5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_511072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703817.1">
        <property type="nucleotide sequence ID" value="XM_024854851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6L5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6L5"/>
    <dbReference type="GeneID" id="36562557"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511072"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="766" mass="85027" checksum="99BDA0D9116C336A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6M8</accession>
    <name>A0A2I2G6M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_438110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703828.1">
        <property type="nucleotide sequence ID" value="XM_024849512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6M8"/>
    <dbReference type="GeneID" id="36557211"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438110"/>
    <dbReference type="OrthoDB" id="4476294at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25635" checksum="30D68DC34EFC07F4" modified="2018-02-28" version="1">MADISENTPLLRDSSDSGAAEHERHDIPTQNPADNSLRFVTALTWSSLVLAVLVVAFDLTVNILEETNYGSGYYMPWVMRIAITAMCVVGLATVLISFLNLVRLYHSQRALWLWLNLIFDFIIALYSIVYCGQGIVLNWAETCDPSSENCRFTRRIEAFAYITLGFGLALGITHLVLFFLRCALAFRMRFWRGFQHWRLPAGQLTVEFTIKFLRQEPQSGEAQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6S7</accession>
    <name>A0A2I2G6S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative UPD-GlcNAc transporter (Mnn2-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_411524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703879.1">
        <property type="nucleotide sequence ID" value="XM_024846896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6S7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6S7"/>
    <dbReference type="GeneID" id="36554595"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411524"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="450" mass="49216" checksum="D2C70E60FAA951A4" modified="2018-02-28" version="1">MLEGDHITRRRRVDNSKRRTDNIDAFSAKGLAAEESFSDIEDSINQHEERREIGSSLGGIMSAVTLVNFTDWTNIVLMVSLIFGGCCANVFALEAIIKDQPTSGSLITFAQFILTALFTLPSFMSLSAGPRSLFIGPRAIPLRSWLIYTAFFVTVNLLNNWAFAYKISVPLHIILRSGGPVASMIVGYLFNSKRYSPGQVLAVVMLTLGVVTAALADAHVKGQPIDLGSEGTEVRFTQTLIGFTILALAMVLSAFQGIYADRLYEAYGRNHWKEALFYSHTLSLPLFIPTYSHLLTQWHALFLSPPLLSKVAAFTTEGGPSNTTFPKVGGLAATTTFPFGTSAGPLWGSFRDSHLAPFLAMVPMRMVYLLMNALTQYLCIRGVHYLSAKSSSLTVTIVLNIRKLLSLVLSIYLFGNDLALGVLVGGFLVFSGGALYGFEGARLRRNIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6X3</accession>
    <name>A0A2I2G6X3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_446494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703922.1">
        <property type="nucleotide sequence ID" value="XM_024850800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6X3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6X3"/>
    <dbReference type="GeneID" id="36558499"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446494"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000051">
        <property type="entry name" value="Glutathione-independent glyoxalase HSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="239" mass="25548" checksum="90CEBAFDB6198595" modified="2018-02-28" version="1">MSPPRRALIAITSAHAPLYPDGKETGLFITEALHPFNVFRKAGLEVDLVSETGSYQPDWLSQQKEWLSDEDRAVWEDHSSEFRSKLDHLLRPSEVDASNYGLFFASAGHASLIDYPDAKGLQDIASEMYGAGAIIAAVCHGGAIFPGIIDPSTGKSIIANRKVTGFTTRGEEEEGVLGTIQSWDRPTIEASAASSGATYISPAGPWDAFTITDGRIVTGANPASAHVTAEASVKAFQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7B7</accession>
    <name>A0A2I2G7B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_464400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704078.1">
        <property type="nucleotide sequence ID" value="XM_024852243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7B7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7B7"/>
    <dbReference type="GeneID" id="36559941"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464400"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="168" mass="18688" checksum="55C2EB110D6FBD8C" modified="2018-02-28" version="1">MYLVVQDWCIYLATAEKALNYIQLNELAVVSVGGCPGHNIVVWGAFHSLGDLYFDQGKLQEAEEMYQRALAGKEKALGSDHMSTLQTVNNIGNLYTDQGKLQEAEEMYQRALAGKEKALGSDHTSTLDTVNNLVILYSDQGKQQEAEEMFQRALAGCEKTLDPDHNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7G4</accession>
    <name>A0A2I2G7G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704100.1">
        <property type="nucleotide sequence ID" value="XM_024847673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7G4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7G4"/>
    <dbReference type="GeneID" id="36555372"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425808"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="107" mass="12012" checksum="9D99C4C3958253AF" modified="2018-02-28" version="1">MSFKAIHNIVILVPQDDKIGDLIEAFSKLSQYVQEHEPETLLYYAVQPKDRNQLVIVEKYANESALKSHAQSEAFKEFGKAISGILQTPPDIKTSTFSGGFEARSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7L7</accession>
    <name>A0A2I2G7L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_168751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704167.1">
        <property type="nucleotide sequence ID" value="XM_024842616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7L7"/>
    <dbReference type="GeneID" id="36550314"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_168751"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="18100" checksum="C8BB8B1E5B5BDF30" modified="2018-02-28" version="1">MLPGRIQHDTDFVRFSRLHICQVAYSLETIRRKFLVKYSVASKSNCPSSIRQSDAALVEDVFIIYTRKRTGLRLWTGPRLDFHDHRAPRDAPFDHVVCSVLGRSDVIDKRGCGRMIRCEGGLRVFLEHTWHRPASSVPGRIHGPGLDAVTGMSGTSATVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7R5</accession>
    <name>A0A2I2G7R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_326417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704195.1">
        <property type="nucleotide sequence ID" value="XM_024843344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7R5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7R5"/>
    <dbReference type="GeneID" id="36551044"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_326417"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="11"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="86" mass="10048" checksum="15A78DC33A1BD23A" modified="2018-02-28" version="1" fragment="single">DKDKPRLTEQEKKNNHIASEQKRRAAIREGFDRLTELVPGLEGQGRSESIVLKKTVDFIHLQLQERHELIAEIERRGGRIDDTFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8B7</accession>
    <name>A0A2I2G8B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_436751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704420.1">
        <property type="nucleotide sequence ID" value="XM_024849215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8B7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8B7"/>
    <dbReference type="GeneID" id="36556914"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436751"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="459" mass="51436" checksum="51E8388D5A0F3B88" modified="2018-02-28" version="1">MGPFIQALHPKFEAYLAQWASGPLSCVSVFHKFVVLASDRDIAHKVFKSPAYAEPCIVPIAKDLLGHKSWVFLQGKAHAEYRRGLTPLFTNKAISTYLPVQEKVLGDYFDKFVAASEKNQGRPMAFMTLFREINCALSCRTFFGDYISQSAVKKIADDFYLATAAMELVNVPLSMYIPFTKTWLGKRTADAVHAEFANCAAACKVNMAKGATPTCVVDHWVLHMMESERYRERTAAGETGLEKPTNMIREFTNDEISETLFTFLFASQDASSSATTWLFQILAQRPDVLARLREENLAARGGDKNKPFDLPMLESLTYTAAVIKELLRHRPPVIFVPYLATKNFPVTPDYTVPKGSMIIPSCYPALHDPEAYPDPNVFNPDRWITGDAESKTKNWLVFGAGPHDCLARRYVPLSMAGMIGKAALELDWEHHPTPLSEEIRVFATLFPMDGANLVFKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8L6</accession>
    <name>A0A2I2G8L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_436834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704517.1">
        <property type="nucleotide sequence ID" value="XM_024849235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8L6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8L6"/>
    <dbReference type="GeneID" id="36556934"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436834"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="283" mass="31406" checksum="8CE9CDD329292148" modified="2018-02-28" version="1">MQCLKETDQILCTDYMLVDMDLPEPRTAPKAPEPGLLPKMKDAAQQALSKKKSGDVKPSRKYNRSALHIKNLDDKTPEARKNLQELASSQRNLASARLTQKQIEYARSVTGTEVKFRDLNDPNAKQRKDDVRVWDTVNLRCISCRGECPVCAGACCLYANASKAIASESADTEKVEKAKRIVKVVEDLSPQVMDVGTYQLCSQPGGCGRYVCPNCCGVCPNEICRDVQCKVHSSAFPCFLFIRRLHVVSMGNVNRAFYIGVQGRPLGALRLARLRGNKGPRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G945</accession>
    <name>A0A2I2G945_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pheromone-dependent cell cycle arrest protein Far11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_509957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704707.1">
        <property type="nucleotide sequence ID" value="XM_024854727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G945"/>
    <dbReference type="STRING" id="1392250.A0A2I2G945"/>
    <dbReference type="GeneID" id="36562433"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509957"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="557"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1064" mass="120053" checksum="50D002CB4F1C51F9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G975</accession>
    <name>A0A2I2G975_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704710.1">
        <property type="nucleotide sequence ID" value="XM_024853286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G975"/>
    <dbReference type="STRING" id="1392250.A0A2I2G975"/>
    <dbReference type="GeneID" id="36560984"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475705"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="864" mass="96491" checksum="DE6AD80AA11127C4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9I1</accession>
    <name>A0A2I2G9I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BET3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_357702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704838.1">
        <property type="nucleotide sequence ID" value="XM_024844235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9I1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9I1"/>
    <dbReference type="GeneID" id="36551935"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357702"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000020">
        <property type="entry name" value="Trafficking protein particle complex subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="189" mass="21355" checksum="B8A601E53BC8744A" modified="2018-02-28" version="1">MSFDASSSAAIVGEPNARVLNTSCLDFLLIELVPMAERLTKELAVEEKLLDDDEVRETTFFRLESLGYRVGQGLAERFSRDRPRFTDNLDVIKFLCKDLWTILFRKQIDNLKTNHRGVYVLTDNSFRPFSRMSMSVRSEAVSMAQAYLWFPCGVIRGALSSLGIHTTVQAETAELPGATFQIKTLQPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9N7</accession>
    <name>A0A2I2G9N7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_358815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704902.1">
        <property type="nucleotide sequence ID" value="XM_024844316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9N7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9N7"/>
    <dbReference type="GeneID" id="36552016"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358815"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000004">
        <property type="entry name" value="RNA polymerase I subunit Rpa43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="9">
        <location>
            <begin position="187"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="438" mass="47167" checksum="942792B9491FEAD4" modified="2018-02-28" version="1">MAVDEMEIDSNPTSHPVQKPEKERKRKHKTKDSSSPSKKKRKHDANLIADKSTTHEKKSKKSSKGSKKSSSSKAVPAAAPSTPDSPYTLTTATLYLPLSPISISPTHALASLLAEHLSPLILTYYAPLQGVVLAYSNASISSTHPAESKSAFTPNDPNPQPLTLARSAGEYGVLYVYLTATFLVFRPQRGQVLEGWVNVQSEGFLGAVVLNLFSVGVERKRLPSDWKWVPPGAYGEEGEGEETANSDADAAKTKSQSQSDDDSSEPSAAFDPEKEHFKPVALASDANPLLDDPASTEVDESAAAEGYFRSVSGHRVRGTVRFRVVDVDVIPGSERDRGFMSIEGTMLTPDEEAQVVEDERNGVMAAFPGAPRRSSSLPIRTDSRTAMSGALPDSSSTAAEPEPEPESQPAAPEPEPEPEQASPTKKSSKSKKKEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9W6</accession>
    <name>A0A2I2G9W6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704972.1">
        <property type="nucleotide sequence ID" value="XM_024849315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9W6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9W6"/>
    <dbReference type="GeneID" id="36557014"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437233"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="187"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="517" mass="57931" checksum="3E02F8DD6DAF9D8B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAG7</accession>
    <name>A0A2I2GAG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_454604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705183.1">
        <property type="nucleotide sequence ID" value="XM_024851453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAG7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAG7"/>
    <dbReference type="GeneID" id="36559152"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454604"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="290" mass="32931" checksum="C8B6179D194B3800" modified="2018-02-28" version="1">MVVGEYRLYHYDPSFPAAVAATACFGVATGMHFVYFVARRTWYFTPFIIGGLCETIGYVGRLLNSQETPDWTTGPYIMQTLLLLVAPALFAASIYMILGRLIQLVDGDSRSVLRGRWITRTFVVGDVVSFLAQAGGGGVLAQADTKDKQDLGNWIIIAGLAVQIVFFGLFMIISVIFHIRMSNSPTKRSVDLRAPWRRFLVVLYVVSTLIMIRSVFRVIEYVQGTDGTLQSKEFWLYVFDGLLMFLVMVVLLLHHPSQLVTRSRQGKHHGRRKRRRHSGRSQYVEDSYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBM5</accession>
    <name>A0A2I2GBM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_435481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705583.1">
        <property type="nucleotide sequence ID" value="XM_024848944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBM5"/>
    <dbReference type="GeneID" id="36556643"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435481"/>
    <dbReference type="OrthoDB" id="6604875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="96" mass="10508" checksum="EBB9BF0A1BD6617D" modified="2018-02-28" version="1">MAGSSENNRNWEVQSEDAKRLLAEDKYDDCLSCRVTGSAAFIGLGVYSYYTGMSNLRKQETAGMLHATKYKMGSRQLGIATISATLVGMGIYRALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBV1</accession>
    <name>A0A2I2GBV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_424749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705666.1">
        <property type="nucleotide sequence ID" value="XM_024847587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBV1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBV1"/>
    <dbReference type="GeneID" id="36555286"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424749"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="701" mass="79110" checksum="323CDB590EB1878C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC61</accession>
    <name>A0A2I2GC61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_463668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705772.1">
        <property type="nucleotide sequence ID" value="XM_024852180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC61"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC61"/>
    <dbReference type="GeneID" id="36559878"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463668"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="13632" checksum="DC0BBDA4657209EA" modified="2018-02-28" version="1">MSGEPNAAWPLADESLTQNILDLVQQASHYRQLKKGANEATKTLNRGTAEIVILAADCNPLAILLHLPLLAEDKNTPYVFVPSKLALGRATGVSRPVIAASITTNEASDLMGQIRTIKDKVERLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCL2</accession>
    <name>A0A2I2GCL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_356064</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705928.1">
        <property type="nucleotide sequence ID" value="XM_024844127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCL2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCL2"/>
    <dbReference type="GeneID" id="36551827"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356064"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="345"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="833"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB50626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="896" mass="100162" checksum="30CD9FFDC1135D56" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCZ4</accession>
    <name>A0A2I2GCZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_406169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706043.1">
        <property type="nucleotide sequence ID" value="XM_024846615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCZ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCZ4"/>
    <dbReference type="GeneID" id="36554314"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406169"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="469" mass="51468" checksum="BA09FDB25D764BCF" modified="2018-02-28" version="1">MSEDQDLMAKISQLAGQINRHKTQNTPSPAPYGNESHSNPYVSRHTRGRPGWAPYRGRPYARGRGGAPHRHRTLILNNASSGTPASNTPSAGGASENDGESRSNTPNGWVAKHDRHMQLINSAIYDKEAQTRAKAMEESRKAKAQRKAQIEQAKVLRYAQGVGRQYPSPAIPKASATAEPMAEYQVYLNDVPFRVSRGGGKLIRVSGATPMCAPLAQRADLPSVDDPNTANNTPKRVTVAGVTFVRSKNGNLHRLGAVTSKRKPTMARKNELCSRFSTTGTCYKGPNCLYIHDPNKVAMCKDFLQTGNCNAGLSCDLSHEPSPHRSPTCMHFLRGRCVNPDCRYAHIRLTPGAPVCRAFAHLGYCEKGAECDQRHVHECPDYANTGVCNKKRCKLPHVDRAGQIRKNTANSRTESTIDEDESDASSEDEEYDQIDSDDVDSDELDDEPEELIGGAGGSELSQQQDYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD26</accession>
    <name>A0A2I2GD26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_446022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706077.1">
        <property type="nucleotide sequence ID" value="XM_024850756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD26"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD26"/>
    <dbReference type="GeneID" id="36558455"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446022"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="116"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="237" mass="26432" checksum="5897B195CB219758" modified="2018-02-28" version="1">MATRSDHPTESLPPRPECDPDQSENERQPSPDGRRDSDERNRDALELHEIETQDDEAGTSTASISSGEYRTTTLRTGSRTSQRTVQSRAPRKGLPGYVQRFWTRNVVLTVPQKSNRDHFALERTFLAYIRTSVILAMQGVLVAQLFRLQRQTDPNSELGYYEVGVPLSVACHCAAILVAFMGAHRFFKQQNAVALGTVYAGGWELYCIGGLIGLIILATFVLSIIITVEIESHIHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE25</accession>
    <name>A0A2I2GE25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_436229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706450.1">
        <property type="nucleotide sequence ID" value="XM_024849116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE25"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE25"/>
    <dbReference type="GeneID" id="36556815"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436229"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB51148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="341" mass="38078" checksum="ABF6532626907FE5" modified="2018-02-28" version="1">METAQRSWELENTISLIDPQRDALYQYDEETHKALSAERPWSKDPHYFKSIRISAVALLKMVMHARSGGSLEVMGLMQGYILPNTFVVTDAFRLPVEGTETRVNAQDEANEYMVSYLQACRDAGRMENAVGWYHSHPGYGCWLSGIDVTTQDMQQLGGPFVAVVIDPERTISAGKVDIGAFRTFPKDYTPPKEQQEEDEYQTVPLNKAEDFGAHASHYYALEVSHFKSSLDTEILSLLWNKYWVATLSQSPLFTTRDYGSKQMMDLSQKVRKAARGIESGGSRGGGPSTAKDQQLEKVVRDGQRIVSEEVKGLLAAEIKMKLFQGIGENGSRSETDTAGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEL1</accession>
    <name>A0A2I2GEL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell wall mannoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_509323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Constitutive protein of the cell wall. Antigen target of host humoral immune response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cell wall mannoprotein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706631.1">
        <property type="nucleotide sequence ID" value="XM_024854664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEL1"/>
    <dbReference type="GeneID" id="36562370"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509323"/>
    <dbReference type="OrthoDB" id="3485059at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.140:FF:000001">
        <property type="entry name" value="Cell wall serine-threonine-rich galactomannoprotein Mp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014118501" description="Cell wall mannoprotein 1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="179" mass="18575" checksum="DED285583A60F42A" modified="2018-02-28" version="1">MYISPRLPLLVLTLFTPFISSTPLLTTRDASAVQSDLAKIATDLRTLTTAVNGYTGGLTAALQIQTKESAVEDDINKAITDTNAASAFTASESSAITAALVGLEPDIDSSLTALVSKKSLFVSAGVVSIVQLDLNNLKTKTDSLSTALQNKATSTDKATIKSKTAELDAAFDSAIAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GES5</accession>
    <name>A0A2I2GES5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pectate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_164815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706672.1">
        <property type="nucleotide sequence ID" value="XM_024842588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GES5"/>
    <dbReference type="GeneID" id="36550285"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_164815"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052063">
        <property type="entry name" value="Polysaccharide_Lyase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42970">
        <property type="entry name" value="PECTATE LYASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42970:SF1">
        <property type="entry name" value="PECTATE LYASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014111480" evidence="8">
        <location>
            <begin position="21"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="813" mass="87408" checksum="0F747641585652F3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEW9</accession>
    <name>A0A2I2GEW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706724.1">
        <property type="nucleotide sequence ID" value="XM_024848492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEW9"/>
    <dbReference type="GeneID" id="36556191"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433429"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="81" mass="9180" checksum="D87DE26F17CFC5DD" modified="2018-02-28" version="1">MRRKFAIEHAMEQSINLSGTRGEHENGGKNNDNPSALAMPRQNGPGSSVVWPNILSLLLSSIISFIRRHFYLRCRPLPMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF36</accession>
    <name>A0A2I2GF36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_376010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706802.1">
        <property type="nucleotide sequence ID" value="XM_024845340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="36553040"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376010"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF9">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="522"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142029" checksum="EC65B1E5DD8CC083" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF69</accession>
    <name>A0A2I2GF69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_352162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706824.1">
        <property type="nucleotide sequence ID" value="XM_024843907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF69"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF69"/>
    <dbReference type="GeneID" id="36551607"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352162"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="210"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="334"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="468"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="630"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="749" mass="84684" checksum="1777D15ACD8BA8FE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFA4</accession>
    <name>A0A2I2GFA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_400492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706866.1">
        <property type="nucleotide sequence ID" value="XM_024846330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFA4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFA4"/>
    <dbReference type="GeneID" id="36554029"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_400492"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="512"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="608" mass="66587" checksum="345EEFC48E3D98C8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFI7</accession>
    <name>A0A2I2GFI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_422635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706947.1">
        <property type="nucleotide sequence ID" value="XM_024847455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFI7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFI7"/>
    <dbReference type="GeneID" id="36555154"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422635"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="224" mass="25478" checksum="90F6CC8938ED9A95" modified="2018-02-28" version="1">MTWIQGSQNPNTPTRCSNRGSHAGMSPPGLQPVLPPGDYSFNVFQSPPEPDQSNMPHYPAHNTLIDPTIPNNTPPTFWDDSPCAMPFDQSSQPTPFMGQTPVRDCTIALQTAMQPPFFTPQLQDNPNIFRPNNATHLPAHGFEQLAPELPTRSQNPWPRRCEWVGCDYSGTFNRKAELMRHLEEKHVAPGSHICPVRRCHRSFNRGYNLRNHVRVKHVRRNDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFQ6</accession>
    <name>A0A2I2GFQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_83882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707018.1">
        <property type="nucleotide sequence ID" value="XM_024855411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFQ6"/>
    <dbReference type="GeneID" id="36563118"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_83882"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="133" mass="14820" checksum="9CEAD763FC6CB793" modified="2018-02-28" version="1">MCTIKSNIHQPFFPPFLTGHTNIAEQLQLDRKQSSPFFFIFIFLSFSLFLISCLFLHGPKSNGSNRNVKTETHHLSCHTYLLPGPTTVAETAGMINAQLRRNPCSQQKRGTDDSPDLTSVGLQGAEGGIRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFY3</accession>
    <name>A0A2I2GFY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707098.1">
        <property type="nucleotide sequence ID" value="XM_024848549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFY3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFY3"/>
    <dbReference type="GeneID" id="36556248"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433666"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="306" mass="33787" checksum="E60AAAAEDFB3D057" modified="2018-02-28" version="1">MLCDKYPQTQNTIRDILGAFPKKKTGGEATSNDGHDVVSEDTELQGKRCGSVQKSRGPNVLFSVDARKLGLTSGGGKEVRLGFPRRERKRPAWLEAKEGPLPAEPKGGPWDIICFNFPHVGGLSTDVNRQVRANQELLVAFFKACVPLLSSPRRVDEVDKDDWEYSDDEDSGTDEEDLPSEDAPGLANSQGRTDPGQILVTMFEGEPYTLWNIRDLARHAGLRVVTSFKFPWGSYKEYSHARTLGEVEGKHGGRGGWRGEDRDARMYVFEIKQEERSVPMRNSTSAGRNGGAGAKRSRGASESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGA5</accession>
    <name>A0A2I2GGA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_352135</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707169.1">
        <property type="nucleotide sequence ID" value="XM_024843906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGA5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGA5"/>
    <dbReference type="GeneID" id="36551606"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352135"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000075">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="13">
        <location>
            <begin position="262"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="625"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB51867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="905" mass="99735" checksum="0684646EAE0C0A79" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGJ1</accession>
    <name>A0A2I2GGJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_95245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707301.1">
        <property type="nucleotide sequence ID" value="XM_024855450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGJ1"/>
    <dbReference type="GeneID" id="36563157"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_95245"/>
    <dbReference type="OrthoDB" id="2145250at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="125" mass="13805" checksum="C26C10C2F0D82139" modified="2018-02-28" version="1">MLKSTSSRCLLHPTSVIHLCLTAAYISTDRTTLLLMRCFGAQATTCGLLLGIANMTRQSFTVFGLSMVPYLAFNAWFGLGHGKGVFTQWLWLDFVGNVTFGLGSLYCARLLGQNEDEGCKTRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGW9</accession>
    <name>A0A2I2GGW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707430.1">
        <property type="nucleotide sequence ID" value="XM_024852900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGW9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGW9"/>
    <dbReference type="GeneID" id="36560598"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472037"/>
    <dbReference type="OrthoDB" id="5070419at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="143" mass="15451" checksum="6C20A1D0B4BDDD3D" modified="2018-02-28" version="1">MSTTTTFSPLPSYLLGALCLVLGLNSFLRPSNEYPRFGLPFESAPARKPSKPTNGANANANCISPLIHLKGIRETSYGLALIALQLQRQETAVTTMAAICAFAGLGDAVVVWRFGNEEFRKKAMGHGLAFLGFGGWALWRVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGY1</accession>
    <name>A0A2I2GGY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">A-pheromone processing metallopeptidase Ste23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_453631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707447.1">
        <property type="nucleotide sequence ID" value="XM_024851374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGY1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGY1"/>
    <dbReference type="GeneID" id="36559073"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453631"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="108"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="302"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="487"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="881"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB52145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1176" mass="133085" checksum="CCF6B2E7D908D42E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHI2</accession>
    <name>A0A2I2GHI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_348705</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707645.1">
        <property type="nucleotide sequence ID" value="XM_024843693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHI2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHI2"/>
    <dbReference type="GeneID" id="36551393"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348705"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB52343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="323" mass="35682" checksum="054E9320D9A8A66C" modified="2018-02-28" version="1">MTLTTHFTLNTGAKIPTVGFGTWQAKPLEVENAVEVALKQGYRHIDCAAIYRNETEVGNGIRKSGVPREEIFITGKLWNTKHAPEDVESALDKTLKDLGIDYVDLYLMHWPCAFKGGDKWFPLNSDGVFELADIDYISTYKAMEKLLSTGKVRAIGVSNFNVRRLEELLSQVTVVPAANQIEAHPYLQQPELLRFCQSKGIIVEAYSPLGNNQTGEPRTVDDPLVHSVAGELGLDPGPLLASWGVQRGTVVLSKSVTPSRIAANLQVRQLPEDAFAKLSSLEKHKRFNFPAIWGYDIFEEVGEDAVRKAAVAAGEVNKTKFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHT3</accession>
    <name>A0A2I2GHT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxypeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_402648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707748.1">
        <property type="nucleotide sequence ID" value="XM_024846433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHT3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHT3"/>
    <dbReference type="GeneID" id="36554132"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402648"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014147610" evidence="8">
        <location>
            <begin position="19"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="264"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="566" mass="62577" checksum="C5B560849283E088" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI88</accession>
    <name>A0A2I2GI88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707886.1">
        <property type="nucleotide sequence ID" value="XM_024848683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI88"/>
    <dbReference type="GeneID" id="36556382"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434301"/>
    <dbReference type="OrthoDB" id="4480082at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="142" mass="16611" checksum="38F6A9E1047A11D8" modified="2018-02-28" version="1">MREFWKSSPSWLKPKSWRRNDEWRRHDEDPQGEDHQNLLPPKKSRRQTWLMGEGLRRTNRSRPNTIATEARFSMFDFGFGDAGQTSVVGDAGTGDGRTKRSSYLEFLAGDSSHSATKVEFRDPSNVRYSSFFDHMVSWDRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIL6</accession>
    <name>A0A2I2GIL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_472600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708012.1">
        <property type="nucleotide sequence ID" value="XM_024852965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIL6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIL6"/>
    <dbReference type="GeneID" id="36560663"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472600"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="323" mass="35969" checksum="13C8E9114C15827E" modified="2018-02-28" version="1">MAYNKSYNPDALPAHAEPEQVAQMIGAMQVGPSQQQKPQRPSPNPSSSGVPPRVPVSGAPNAQFQSALASRPPVQAQHPYNNNKPLPAGPQQNHHQTHPLHPSPPPQNYGFGPPPSQPVRNRPQPTSRPPRSPNPPPLGVPDDDPQQLFPLFRAANSSHSGALTEMELGSALVNGDYTSFHPRTVKMMIRMFDRNSSGTISFDEFVSLWRYLAAWRELFDRFDVDRSGRISLQEFENALSAFGYRLSQPFVTVLFTTFEAKGRQMNGPPKGPPSTGMSFDLFVQACISLRRMTDAFKRYDDDRDGYITVSFEEFLTEILQLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJT6</accession>
    <name>A0A2I2GJT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras1 guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_423914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708443.1">
        <property type="nucleotide sequence ID" value="XM_024847536.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GJT6"/>
    <dbReference type="GeneID" id="36555235"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423914"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="371"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1415"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="750"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="894"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1130"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1178"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1379"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="963"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1387"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB53141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1661" mass="184371" checksum="188553EB1CBE487B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKM9</accession>
    <name>A0A2I2GKM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="22">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">P170DRAFT_463124</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="function">
        <text evidence="21">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 22">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Mitochondrion inner membrane</location>
            <topology evidence="21">Peripheral membrane protein</topology>
            <orientation evidence="21">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 22">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="22"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708738.1">
        <property type="nucleotide sequence ID" value="XM_024852140.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GKM9"/>
    <dbReference type="GeneID" id="36559838"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463124"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 22 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="16 21" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 21" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17 22" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tr-type G" evidence="23">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="141"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PLB53436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2101" mass="234180" checksum="6344C73FE62BE19D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKS7</accession>
    <name>A0A2I2GKS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_435110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708784.1">
        <property type="nucleotide sequence ID" value="XM_024848860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKS7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKS7"/>
    <dbReference type="GeneID" id="36556559"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435110"/>
    <dbReference type="OrthoDB" id="5419927at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="645" mass="73965" checksum="662BF33B4628392B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL96</accession>
    <name>A0A2I2GL96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_420484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708954.1">
        <property type="nucleotide sequence ID" value="XM_024847297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL96"/>
    <dbReference type="GeneID" id="36554996"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420484"/>
    <dbReference type="OrthoDB" id="4498308at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="739" mass="83714" checksum="DDAED6BAB956C523" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLE2</accession>
    <name>A0A2I2GLE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_2424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708998.1">
        <property type="nucleotide sequence ID" value="XM_024842962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLE2"/>
    <dbReference type="GeneID" id="36550661"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_2424"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="732" mass="81486" checksum="1126F2ADDAE778B1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLI3</accession>
    <name>A0A2I2GLI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_431552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709042.1">
        <property type="nucleotide sequence ID" value="XM_024848062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLI3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLI3"/>
    <dbReference type="GeneID" id="36555761"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431552"/>
    <dbReference type="OrthoDB" id="5126078at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="314" mass="35768" checksum="8BCD28C8AFA6B46C" modified="2018-02-28" version="1">MALRLITWANQISYDKAKIPHPLPPDFKEPKENVTVELMENILNKVVFAGDERYDTVFVNSQCPPYPESDSRADLAIKYITKDNKLQTLCIIEAKRPRASGHYNTDLVEEEALDYCEEFFKDPSHDCLFVYAATIIGVKIRLWKVNENGRKLEALSDNPYRGTSSHYLDLGENADAEKIIKIFRKMLTIAPEPWIFKGDDSFQPTSKSGAHHLNKIDTNAQKGLPCHLEPIPIPPLEFLGSSLQAQEDTPTMDSAPFPPRNYTKVATFHRTHSDWCEWVLYDDQNGSGPCSEWSLDNGYFVNVKQKLYTGHDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLX5</accession>
    <name>A0A2I2GLX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_504763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709175.1">
        <property type="nucleotide sequence ID" value="XM_024854226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLX5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLX5"/>
    <dbReference type="GeneID" id="36561932"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504763"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04433">
        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="454"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="582" mass="64919" checksum="A700E56C7EBE5BEC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMA9</accession>
    <name>A0A2I2GMA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_469485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709315.1">
        <property type="nucleotide sequence ID" value="XM_024852638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMA9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMA9"/>
    <dbReference type="GeneID" id="36560336"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469485"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38386" checksum="724832313FA156B9" modified="2018-02-28" version="1">MTPTPTTSSTAAASATCIDVAPGKNGYLPPEACDALLFYEPSFAAAILFAVLFGLTTALHTVQAFVYKKRYAWVVIMGATWELLAFVFRVMQTRQQNKDIWGTLYELFFLLAPIWINAFIYMTLGRMIYYFLPDQKLAGISARRYGALFVSLDILAFLVQVAGASMSTNDSMGHKFVMLGLHLYMGGIGLQELFILCFLGLAIKLQRKVSREGYVAGDEDGKFPARQGLFHPSRLFYGIYFALAMITVRIMFRLCQYAQGYDATNPVLTTESYEYVLDAAPMFLALLALNVFHPGHVLRGPRSDFPRLTRAEKKELKRQKKERKMEMKRVDRGLYLENDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMU5</accession>
    <name>A0A2I2GMU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_431858</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709523.1">
        <property type="nucleotide sequence ID" value="XM_024848135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMU5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMU5"/>
    <dbReference type="GeneID" id="36555834"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431858"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13592">
        <property type="entry name" value="PBP2_HisGL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="59"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB54221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="314" mass="33434" checksum="35A5790744A4CEDF" modified="2018-02-28" version="1">MDLVNHLEGRLLFAVPKKGRLQQATLDLLAGCDIQFRRETRLDIALVKNLPIALIFLPAADIPTFVGEGRVDLGITGRDQIAEHDAQLALGETSQVEEILDLGFGGCKLQVQVPEKGDVSEAKQLVGRNVVTSFTALTEAFFAGLESEGDASKLARADGGYDIRTKVKYVGGSVEAACALGVADGIVDLVESGETMKAAGLKAIDTVVESTSVLVKAKNTQNPLVDLITSRIRGVITAQKYVLCQYNIPRSELATASSITPGKRAPTVTALEEENWVAVSSMVEKKKIATVMDELTKVGASDILVLNIANSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN36</accession>
    <name>A0A2I2GN36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_469755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709599.1">
        <property type="nucleotide sequence ID" value="XM_024852674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN36"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN36"/>
    <dbReference type="GeneID" id="36560372"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469755"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB54297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="592" mass="65951" checksum="9F5765FF23CCAFCF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNF1</accession>
    <name>A0A2I2GNF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="9">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_432027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="9"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709692.1">
        <property type="nucleotide sequence ID" value="XM_024848172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNF1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNF1"/>
    <dbReference type="GeneID" id="36555871"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432027"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="422" mass="45812" checksum="FDAF0B655F6F5A93" modified="2018-02-28" version="1">MIELGLSRISRLVQQTSLNWQAIHIAGTNGKGSISAYLSHLLTSGGVRCGRFTSPHLVDRWDCITIGERVVQESLFRQVEAQVKLRDQALGIGASEFELLTATAFEIFHHERVEIGVVEVGMGGRLDATNILKDVLVSVIAKIGLDHQNLLGNTIEEITREKAGILKRGVPCVVDGTNSPAVITTLQDRVKELGIDATYTRPETPNEHAPSLGQLFSKLDLLPHQQANVCCAVSALKFALPKLRPDLGVDSLLPHLSNVEWPGRLQSISLAPLIAREEPILLDGAHNSQSAEVLGQYVERRLRPQEGSVTWVIAASRGKDIPELFGSIIKEGDRVATTAFGPVDGMPWVKAVEPEELATCVRSFSGIGKVQSFGTDIVAAIDWASKEANGSPMVIAGSLYLVSDVLRHLREAKKQPRAMVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNG1</accession>
    <name>A0A2I2GNG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HLH DNA binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_344067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709702.1">
        <property type="nucleotide sequence ID" value="XM_024843440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNG1"/>
    <dbReference type="GeneID" id="36551140"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344067"/>
    <dbReference type="OrthoDB" id="4526539at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42993" checksum="96BA7326A6B28F7E" modified="2018-02-28" version="1">MGPISEISQRCSLPGVRSLSSNTSAAADMTEDRRLPPLPRVDPLPRGPFNPFDSTALAHSPQSSQDSTFVVKSSPWPAGEHIVTPPSPANSADSTWPDSQSSQKAFEWPQELTASDLMSLIAPKEISRKPPLQQLCGRKRKGSMISGESDDQREKHRIAEGNRRKNLSHLHRELDSRIHSWFLERAGWNPAKSLPESKEHIVQGAIYLIDFMLLVIIHLIRQENEMPRQLAEKLQPQMRCMQLQQLVSNLQEQNQLTQQQMKAMKQENQMLEERNQALEVQLKSYEHMFRSPKTEHSTPQPLAPLPDHKPRHMLPGLRVFCDEIGAPGTEASRLEPFPTVTSQPFGHSMISHTPPMTGPSSPVFVPTYSVPHSRRQSVIPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPV4</accession>
    <name>A0A2I2GPV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">pectin lyase</fullName>
            <ecNumber evidence="12">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_452486</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710209.1">
        <property type="nucleotide sequence ID" value="XM_024851278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPV4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPV4"/>
    <dbReference type="GeneID" id="36558977"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452486"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014124106" description="pectin lyase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="16">
        <location>
            <begin position="90"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB54907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="375" mass="39654" checksum="F334ECDE81731D42" modified="2018-02-28" version="1">MKLLSTSLAALLGLAHLGAAQKVSGAAQGFASGVTGGGDAEGQEPSDIDQLKEWLTDDTPRVILLSKEYDFTESEGTDSGNVCASWGEGESCQKIIQDDCGSDPASTGTWYKAAKTPIDVASDKTLLGVGDSAAIKGKGLRFRGDVSNIIVQNIHVTDLNPEYVWGGDAITFDGADQIWIDHVTTARPGRQHYVFGFNPSKRITLSNNFIDGESPYSTGCGDKHHYWTFEMVGEDDQITLQNNYIFSTAGRSPALSGGTLLHAVNNVWEDNNGHALEGGDDGARGIFEGNAFISVNQVIGDYAGRIFTAPESALDQCQSALGRACEANVVSDSNDFTESTDTSFFSDFEGLEIAPATSASEAQSSVPNNAGAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPZ9</accession>
    <name>A0A2I2GPZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_28139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710255.1">
        <property type="nucleotide sequence ID" value="XM_024843192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPZ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPZ9"/>
    <dbReference type="GeneID" id="36550891"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_28139"/>
    <dbReference type="OrthoDB" id="4509805at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45544" checksum="677295BB4541F1B4" modified="2018-02-28" version="1">MKMGCEYDHKCGKERDGEKQRGRGGLPLIPMTWSLSCLSAYKHQSQPSQQQTTTTTTTPTSSSLVVGIDFGASKTVVSYRQSGERTIYPRPFCLHGSSMIPTAIAYTSKKPYAIGQLAQKDPNCVYWLKHILHESCIVDEPDDTMIQGLVKQARERLPTKQQETPYLVVVDFLGMLLQYFRAELEDFPHLKNLPRVYTFTIPATWSENTRMTMKKVAHLAGFGHQNAKVCFITEAEAVAVYAANEIGSDMGQFSLENEGAIVCDCGGSTIDLTAFHVEQTNPSFEYQRLTAYTSKAWGAVQLQCLAYHRVLQRQTNRSSRREGLRFIDVPFTQWAPGAFPYGPISLMDPGRVGIPLAVANEVYKELVTKIVGYIKQQIDCASVYVGGDLIKKVLLVGGLTQSPEFSDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ05</accession>
    <name>A0A2I2GQ05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_374367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710258.1">
        <property type="nucleotide sequence ID" value="XM_024845284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ05"/>
    <dbReference type="GeneID" id="36552984"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374367"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="387"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="672" mass="74387" checksum="AE257CB0339184F5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ50</accession>
    <name>A0A2I2GQ50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_432521</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710300.1">
        <property type="nucleotide sequence ID" value="XM_024848283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ50"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ50"/>
    <dbReference type="GeneID" id="36555982"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432521"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="160"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB54998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="312" mass="35380" checksum="3D6D750274C80E77" modified="2018-02-28" version="1">MSSATITLVVQPRGKPIKGLPSELEIPANVSTAGIYDSLAQTSGFSIHRLRITKGSDRSVVPNSRNTIVDHLGLKDKSVIHVKDLGPQISWRTVFIIEYLGPLLIPILFLYPLRSLIYYNFDQPLPERSSLQLFVCELLTVHFLKREFETVYVHRFSNATMPARNIVKNSAHYWILAGFNIAYWVFRPDAASMTSHPNPALFYPGLAMFVFGELANFNAHLILRDLRRPGSTERGIPVGFGFDLVTCPNYLFEVIAWLGVYLVSGLSWSVLFFVLVGGAQMVSWAKKKERRYRKEFGDKYKSKKFVMFPGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ85</accession>
    <name>A0A2I2GQ85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_442950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710333.1">
        <property type="nucleotide sequence ID" value="XM_024850500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ85"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ85"/>
    <dbReference type="GeneID" id="36558199"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442950"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0401">Integrin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014119891" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="275"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="512"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="730"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="799" mass="86332" checksum="C2CF39427448BC74" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRJ0</accession>
    <name>A0A2I2GRJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative proteasome regulatory particle subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_422039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710801.1">
        <property type="nucleotide sequence ID" value="XM_024847409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRJ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRJ0"/>
    <dbReference type="GeneID" id="36555108"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422039"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="228"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="491" mass="54303" checksum="302EB75C16D48749" modified="2018-02-28" version="1">MGSDPQYIKHPDLILAQHVFNLSNPACPQTVQQASLKKVQSVISDNKMAPFYRHLAHPVEGILNHTGEGVPQHQGGSAKSLITSNLLASRKSPQKIEFPWDEALYQSLVEDNRKELETFQKEEDEAEEAAGETEVLAARGKRAEFWARVGDKDKAIESHEALLEKTTFLGTKIDLVMAMIRIALFFGDSLFVKKSIERAETLVESGGDWDRRNRLKAYKGLHLLTIRSYSLAAPLLLDSLSTFTSYELCSYSALVIYSVLAGSLSLKRVDFKAKVVDAPEIRAILGSGEDRLAALTGEVSSGPSAGDEDMKDTSTASSTPGAATTAVNLTTFAAGSGIQAESEVPVDFTPLADLVNSLYNGNYRTFFVALAAVEDQFLTQDRYLHEHRAWFVREMRLRAYQQLLQSYRVVGLTSMANDFGVTVDFLDRDLAKFIASNRIACTIDRVNGIIETNRPDDKNKQYADVVKHGDALITKLQKYGQAVRLRGSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRU0</accession>
    <name>A0A2I2GRU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_45173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710892.1">
        <property type="nucleotide sequence ID" value="XM_024851215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRU0"/>
    <dbReference type="GeneID" id="36558914"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_45173"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="99" mass="11791" checksum="01C7931AC11AA679" modified="2018-02-28" version="1">MKCLYPLNMHSFYIQEMHFRTARQYETTHQEIPHVTQNNDRNNDQLKQLAAMKPHAFIQSVRIRSPMSNWGLYSKPGLDCNRLIVPERTNDHERATSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSD5</accession>
    <name>A0A2I2GSD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidine and deoxycytidylate deaminase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_461563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711078.1">
        <property type="nucleotide sequence ID" value="XM_024852046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSD5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSD5"/>
    <dbReference type="GeneID" id="36559744"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461563"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="216" mass="24398" checksum="EB5D79D8F91EABE7" modified="2018-02-28" version="1">MSSLHRNYMQQCIGLAEKSPPRPTNFRVGAVLISRKDGDLWAEDDRVLSTGYTMELDGNTHAEQCCLSNYAAAHSVPDDRVHEVLPSEPGRKLVMYVTMEPCAKRLSGNAPCVQRIIQTKEGGRNGIQKVYFGVKEPGTFVGQSEGCQRLTEAGIEWHVVQGFERRILEVAVAGHENRDEEVKSALDQVETRLDDVSDDERERQRQMPRNPKKRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSM4</accession>
    <name>A0A2I2GSM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_433342</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711168.1">
        <property type="nucleotide sequence ID" value="XM_024848465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSM4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSM4"/>
    <dbReference type="GeneID" id="36556164"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433342"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="54"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="270"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="491" mass="53795" checksum="AA0E6DEB9EB33DD4" modified="2018-02-28" version="1">MSEYKISYNPELVWLLSLRLVLSNDRDTYQLYHRYEETPPKHDWKTAALRGPALPALGNAVAGAVGAAVSNLATYPLSLIIARLQTQSQRKKDKGKAKSDGDDEDEGDDEEYTDFIDAARKIYAREGLGSFYTGLAQDTAKTVADSFLFFLAYGFFRQRRINARFGASRRNKHTVLPVLDELAVGVLAGAFAKLFTTPLANIVARKQTSKASVSARDIAAKIKAEKGLKGFWSGYSASLILTLNPSITFFLNEVLKYSFLRRDQRGGRSSSAIITFLLAAISKSAASSVTYPFSMAKTRAQVTGSNAPAAGKSADSGEKDDTDEGISLTPAIISNVIAIARTDGVSALYAGLPGEILKGFFSHGFTMLAKDAIYSAIVHSYYLLLVVLRRYPTPEELIERAREQAEEWADAAREGARDLADKARQDTGEILGSHSGNVAVEMTSSSGPGGVDFWSDSNETAEMVGDYVEDEAAEWRSLYHWFWEKEKFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSN5</accession>
    <name>A0A2I2GSN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_443584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711194.1">
        <property type="nucleotide sequence ID" value="XM_024850563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSN5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSN5"/>
    <dbReference type="GeneID" id="36558262"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443584"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="874" mass="98493" checksum="FE416408DA794CDB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQ45</accession>
    <name>A0A2I2FQ45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_370644</name>
        <name evidence="4" type="ORF">P170DRAFT_370824</name>
        <name evidence="2" type="ORF">P170DRAFT_396032</name>
        <name evidence="5" type="ORF">P170DRAFT_419517</name>
        <name evidence="3" type="ORF">P170DRAFT_420280</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000034">
        <property type="protein sequence ID" value="PLB42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000027">
        <property type="protein sequence ID" value="PLB42791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQ45"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370644"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370824"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396032"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419517"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420280"/>
    <dbReference type="OrthoDB" id="4231495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="140" mass="14801" checksum="2739041F545475FE" modified="2018-02-28" version="1">MWILHGNVTERGDVGGGPGKSYLFFLTAYHPEIGLSGARVPWLAEPCTFAGSGAPPTTLENPREGIVFTPGRTHNRSRSPRIGSKGRARWALGGTPRSRGALAGQPAGAPQHRAGDALGRLRPSGGRLTTNLELVRTRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRE8</accession>
    <name>A0A2I2FRE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_514483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698516.1">
        <property type="nucleotide sequence ID" value="XM_024855210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRE8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRE8"/>
    <dbReference type="GeneID" id="36562916"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514483"/>
    <dbReference type="OrthoDB" id="4489302at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="274" mass="31694" checksum="5FA911908A8CA12E" modified="2018-02-28" version="1">MSEEERIGVVLLVTAPIGSSFRNIVRAVGREPPSSPPVAWESRENRALPNIESRLKFMTHYALCVIPSEIWDHPSLTLLTKFAHAKFWDHPGDSTSSTASRSSRSGSIIERNADRTWEKPYIRAIESGQEIGRTNMFYRGLRRDWRYMPVYWNCHDLAIRLAYLIVPASNDVMGFLRELMRGLMEAYFRERALVWQSTKVALGIWTTGALRTLDATPSLTAVDTVLFMAELGVGYYVSEATMAKLRTKEMYMRKLEEQFPKLKPLHFHWRRWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRX8</accession>
    <name>A0A2I2FRX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_514608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698669.1">
        <property type="nucleotide sequence ID" value="XM_024855225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRX8"/>
    <dbReference type="GeneID" id="36562931"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514608"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="444" mass="51342" checksum="35119584E851D2BA" modified="2018-02-28" version="1">MRLVTRSIRTTPKRLFSSLRRKPLPTPSPGPLIRQDERVDEEKVPGHKSKYFYPARPGEVVGDRFQILVKVGWGVSSTVWFARDMRGAESDPEAAVALKITNSNQNAEDEREIEACIANTDPSHHGHPFLRTSSECFEIEGPEGKHLCFAYEPLREPLWLFRRRFVDEKIPFPIIKLYIRFLLAGIDYLHTKCKIVHTDLKLENIMVTFEDPSVLNDFMNSQLDQPMEYKIDSTGRPVFRRRNNFGPLKKFNNMPMLVDFGIAAKFDSDNAMGIYPIQPHHYRAPEVILGCGWKASADIWNMGTILWDMIEGEELFQQVYDNRGRYDAKAHLAEMIALLGYPPPELIARYQSKRGLKWPTRIRWQDGELSDNADQFFGGPFFDDNGNFLYRGLIPDRKLADSLPSLEEEEREDFLSFVKGMLCWRPGERKTAGELLEHPFLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSG7</accession>
    <name>A0A2I2FSG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dual specificity protein phosphatase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_55860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698853.1">
        <property type="nucleotide sequence ID" value="XM_024855272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSG7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSG7"/>
    <dbReference type="GeneID" id="36562978"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_55860"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="316" mass="35581" checksum="55CB636F177280E9" modified="2018-02-28" version="1">MALPSRCTEAPMSQQPSTHYVRTHEYVAGAGRVQRTNFYALAGIDSQIGVQLEPVSSDSHCFPEGEFVPPGFFERVHSDMFALPPRMNDWKYHMRREAQMILPFLYLGPWACLKDRVWLEREGFTLLLAVRDQRLAHARLISGEKAAMELGIETCAVDTVDNQDLITALPRAIRLINDHVSTPANAQSHNSSRRKILLFCETGNGHSAGVLVAYLMAMFNLKFHQALQIAHLQRFCIDIDEPLKNLLLSFESILAAKRDVESSRRMASANPGLATLTTTNRKRDLEDPNDMEDSMDMDGHDGLFPARRGTAPFQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSI1</accession>
    <name>A0A2I2FSI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_441051</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698895.1">
        <property type="nucleotide sequence ID" value="XM_024850223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSI1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSI1"/>
    <dbReference type="GeneID" id="36557922"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441051"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="82"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="245"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB43593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="47033" checksum="7D52BF5F35049A4F" modified="2018-02-28" version="1">MSRPSSIAQRPLTLTEELEKLEQSITLTLQEIDHNFSQAHRIVTSSILPLVEQYADHSKDVWQGAKFWKQFFEASANVSLSGYEEKPDESTMQEQTMTEEDVTKSELDESVSYETPSSERHRADDLELTDLNLSSHSTPRAQLDRHAQPENDTTVTSSIAHPSPYHEPEPHFEGEDSMLPSTPGKTPSRPQDHTYNSNHTFDDPMSSSPFIERGAYADDDPMSHQKDHDPVMHRLQDRTYRVQATPLGKGYGGGGSRPKFTVTPKPSTSKSKYGFDDSPLSSPEPEAPQLHAEIFSSPLKARTPGTGRKRRPSSNHMRITPQPGLSVLTPAKGGGRYQSGFDSDDDFGDDDDMDLGPSPPKTMQFHIPQSRLMRTPAKEASKRIVEDLLFTAGANDTTDDVPEEQSPSVIRRVERLEDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT18</accession>
    <name>A0A2I2FT18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_441231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699082.1">
        <property type="nucleotide sequence ID" value="XM_024850269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT18"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT18"/>
    <dbReference type="GeneID" id="36557968"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441231"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB43780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13556" checksum="9CCCCE8E034A4268" modified="2018-02-28" version="1">MGYISRLTTFFGLVLLAHAGYSAHEHTLLYSNARLSSTSSASALPHDIVIEALVSLLIVSVGLVLGAPALKPISWSEWAGQIEREGGARNPYRRLEQRYSFWDVRAKRKEFADWVKGDIPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTC3</accession>
    <name>A0A2I2FTC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_430904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699200.1">
        <property type="nucleotide sequence ID" value="XM_024847995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTC3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTC3"/>
    <dbReference type="GeneID" id="36555694"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430904"/>
    <dbReference type="OrthoDB" id="5417895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB43898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="82686" checksum="6DF04FA0D54FB034" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTD0</accession>
    <name>A0A2I2FTD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_368985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699163.1">
        <property type="nucleotide sequence ID" value="XM_024844886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTD0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTD0"/>
    <dbReference type="GeneID" id="36552586"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368985"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="261" mass="29157" checksum="0B57DDEB099A7E15" modified="2018-02-28" version="1">MAPEIGKPVFPSTPTSPELSPDTRDSPTPSKPSLYHHSLVTSDFDALRFHAAAALQLQYPSTSTSTTPIQQSLPSSTHLIASPYNSPPHLLDLTTLDTPNRLLALALSILKPVRDDYATAPYADALNWPAVFSFLRDLAAHEGFHWPKSHFYVVVFRSRLQDGIDHQRLHDLDAYSHQEATVSGGLLKYWFGAKNERRENLATCLWRTRQDARAGGTGPWHKKARGAARDMYEQITFTTLKLEVGEGVTSWGFGDWTEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUI2</accession>
    <name>A0A2I2FUI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF614 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_430202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699602.1">
        <property type="nucleotide sequence ID" value="XM_024847938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUI2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUI2"/>
    <dbReference type="GeneID" id="36555637"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430202"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="337" mass="36589" checksum="C46DD975940AEDEF" modified="2018-02-28" version="1">MARRLHLDTSNLGANQRYSFLETPLEMQTAGLQIPPQPPQPATVPEAQHEQATPEQVQQPLNEKTHPLPAGSDLSHHPHGPNIDHHPAIYAPFADEAPQQNQHPDAVVPDYSYVVPPGSPGPLPIKTNPAAPDQYPERLPVAVVPDANPLQTPQMPRFPPPVASGAPHTSAVDGLTVYHQPGQVAHPNQVVKGGTWSHSMCDCSNIWTCCLGLICPCILYGKTQHRLSLLSRKEDPTNMLGYETCNGSCTAMALLCGCQWLLATVQHTRTRKAYGIRGDIASDCVRATCCTCCTLIQDETEIRKREEERGKAAIATGTTLASPYLPPVQMSYGPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUS6</accession>
    <name>A0A2I2FUS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_440696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699695.1">
        <property type="nucleotide sequence ID" value="XM_024850138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUS6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUS6"/>
    <dbReference type="GeneID" id="36557837"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440696"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB44393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="404" mass="45623" checksum="6C5BD831135B635F" modified="2018-02-28" version="1">MSSQVTPSKQAASSLENLKMNDSPVKKLNFESVGKENAPSSTPVDVTATKPVAEKPAEASSIAAQIKEMEANEPLLQENPHRFVLFPIKYHEIWQMYKKAEASFWTAEEIDLSKDLHDWNERLNDDERYFISRVLAFFAASDGIVNENLLERFSGEVQVPEARCFYGFQIMIENIHSETYSLLIDTYIKEPKQRTYLFDAIDTIPCINKKAEWAIRWIQDKESTFGSRLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLFSHLNNRPSKQVVEDIIVEAVAIEKEFLTDALPCALLGMNSKLMCQYIEFVADRLLVALGNSKYFNATNPFDFMESISLAGKTNFFEKRVGDYQKAGVMASTKKDAAQEETKTGNGGLSFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV55</accession>
    <name>A0A2I2FV55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin patch protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_368358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699793.1">
        <property type="nucleotide sequence ID" value="XM_024844855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV55"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV55"/>
    <dbReference type="GeneID" id="36552555"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368358"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="323"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="815" mass="89805" checksum="28F53461ECFC6356" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV93</accession>
    <name>A0A2I2FV93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Estradiol 17-beta-dehydrogenase 12-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_288371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699870.1">
        <property type="nucleotide sequence ID" value="XM_024843225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV93"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV93"/>
    <dbReference type="GeneID" id="36550924"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_288371"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="341" mass="37586" checksum="17CA508F2440683F" modified="2018-02-28" version="1">MCSVCHQKAASTLHITMIQLPIYISGVLVHLYILTKLCLHAATYLFPSSIHEYLSTTEDHESWALITGSTAGIGFGFAQELCAHGFNVIIHGKDDQELQDAAAQLRSAFPLRSIRTFLFDASTPTASLATSLTPVLQDISLRVLVNNVGGQGGQTRSTYQRLRDFSSEEVTRVMNVNAHFTTQLTRILLPVLSRAPSLVLNISSLSATGLPYLSVYAASKAYIDSFTRALHAEMRAENMPVSVQGIICGNVQSDGHPLAEGWFVPTSRGMARAALQRLGPGSRHSPGFRLGYRPVLVAAYWPHVLQAWGYDILPEAAREWISIRVLRGLKDEWESVDRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVA8</accession>
    <name>A0A2I2FVA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_417179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699808.1">
        <property type="nucleotide sequence ID" value="XM_024847162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVA8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVA8"/>
    <dbReference type="GeneID" id="36554861"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_417179"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="12"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="39535" checksum="D65847BAD7D8A986" modified="2018-02-28" version="1">MAQDSNPSFVLRAVKDVALEDRPVPALKDPWDVRVRISETGICGSDVHYWQRGRIGDFVLESPIVLGHESSGVIEEVGSAVRNLKVGQRVAVEPGVPCRHCNYCRSGSYNLCPDTVFAATPPHDGTLSKYYITQSDYCYPIASHMDLEEGAMVEPVAVAVQITKVGRVRPNQSIVVFGCGPIGLLCQAVSKAYAARTVIGVDISQSRLDFARVFGADGVFLPPARPEGVDECEWSARVAGMIKEQFGLGEGPDVVIEATGAQACIQAGVHLTRKGGVYVQAGMGKENVVFPITTACIRDLTIRGSIRYTTGCYPTAVDLIASGKVDVKRLVTDRYDFENAEEAFELVRQGRENVIKVIIHGYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVC9</accession>
    <name>A0A2I2FVC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_288723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699884.1">
        <property type="nucleotide sequence ID" value="XM_024843228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVC9"/>
    <dbReference type="GeneID" id="36550927"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_288723"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="104" mass="11495" checksum="E2EE09374E4DF255" modified="2018-02-28" version="1">MVWTCTIPSSPLPCLTFSLPPISCTNPHWQQKTSSMMSGPKRPKKRRGSTAVIGSWRQSMDAWNGGKCSRRLSARADQGVLEWERRALCYGIGLDGPGREDSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVI7</accession>
    <name>A0A2I2FVI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Molybdenum cofactor biosynthesis pathway protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_367866</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699933.1">
        <property type="nucleotide sequence ID" value="XM_024844828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVI7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVI7"/>
    <dbReference type="GeneID" id="36552528"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367866"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="88"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB44631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="701" mass="77944" checksum="D4D8869C9AE87D92" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVV2</accession>
    <name>A0A2I2FVV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_512922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700071.1">
        <property type="nucleotide sequence ID" value="XM_024855036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVV2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVV2"/>
    <dbReference type="GeneID" id="36562742"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512922"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF5">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="340" mass="38207" checksum="2A1849B859693C77" modified="2018-02-28" version="1">MSIPPLINHIYTADPSAHVFNDRIYIYPSHDRESTIPFNDNGDQYDMADYHVFSLDVPGDPASVTDHGVVLSTPDVPWASKQLWAPDAASRNGKYYLYFPARDHEGVFRIGVAVGERPEGPFSAEREYIRGSYSIDPAVFVDEVEGGGDGRGYLYFGGIWGGQLQCWSRGGSSSGDGQGEWEFDASKTGPQEPAGAGEKALFPRVARLSEDMLSFDTDVKELQILDEAGAPIAADDHDRRFFEAAWMHKYNGTYYFSYSTGDTHYLAYATGKSPWGPFTYRGRILEPVLGWTTHHSIVEFRGRWYLFYHDCELSGGVSHLRNVKMREIGYDEKGEIYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW41</accession>
    <name>A0A2I2FW41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_391273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700165.1">
        <property type="nucleotide sequence ID" value="XM_024845935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW41"/>
    <dbReference type="GeneID" id="36553634"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_391273"/>
    <dbReference type="OrthoDB" id="3891782at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47162">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="474" mass="53671" checksum="AF28070662077ECC" modified="2018-02-28" version="1">MATSQNPSWVLKKAVLVYTPDFDVSCFARLRIAHDKTANQGSISLWITADLANLTGRSQVLTLNIPPERIEKCALARISNDSLCSPNLVSILRAPVANVSAVSTLSLRLNTTGIVLCPSELKSLCPANPGDSNFHAFAKICQSEFLRLHFSRRQFVNNELDQLEIFSRSLRERSLQTESFDHARHGVVQRDWRAFSLSLDPPPYCEEPVRQVKQVDPPLYNESVSGQVVGKRRRDPWSSPDDENRKRLLLPSPQPIDSPTEVNTPTTLSPSPSIRPTCFTRASSPGRTERHKLMRLEHELRGLSDDLICELLIRSGRQHLLVIPKIVDNELPSESEKVSFAEVGMIERRLKRYVDETIERRLKSHVVDEIVDGAVSEYRDQIFDECKTHECEFREQVDDCNSEVRITANECMSEMKEQAQKHMREIEEQAQQYMNDIEDQGNAVELSTKEKVAKLKQTSLGPSHEGTNARCSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW53</accession>
    <name>A0A2I2FW53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_501658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700098.1">
        <property type="nucleotide sequence ID" value="XM_024854166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW53"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW53"/>
    <dbReference type="GeneID" id="36561872"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_501658"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014169754" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="372"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="476" mass="50759" checksum="C3E1504FD5F80C5E" modified="2018-02-28" version="1">MRSLIAPLLLISAKWTNALTFEIPSSPPAGGNKIDPTPVGVSIEFFAFPDYIEKLPLTNACLATLEDVLGAKPPIRIGGTTQDRALYDASLQSAVDYTVDSPDDAPDSLTFGDRFMELAGSYEGEVTIGLNRRLDDVENTIAAAKVVQSKVGNLYAIELGNEPNFFKSSDPIAHGEAWTAAADAASQVSWQTSVSEGLDNKQSFVQAGVFFDTESFTAENLAAKEEETGSTGYVRSFCHHFYPQSSSNANLSRLIDHADIVDGVATFESQVAAAQQLNLDFIMGETNSATQGGGGISPTYGAGLWILDYIMQSTMKGIQQLFFHQGTIGNCQYCWWQDSVNAPFYGAYTAALALSGASQITQLDAGDSRYAGYAIYDGDGHPTRVLLYNSDYYASGTRSSINITLTGIPSSSTVSAKRLTADAATVVGQEGISIGGQAFGDGSCELEGEEDRETIAVENGRAEVGIRASEALLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWD2</accession>
    <name>A0A2I2FWD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_415778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700219.1">
        <property type="nucleotide sequence ID" value="XM_024847081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWD2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWD2"/>
    <dbReference type="GeneID" id="36554780"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415778"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF134">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="498"/>
            <end position="499"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB44917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="571" mass="62969" checksum="28C92D16179ED16A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWW5</accession>
    <name>A0A2I2FWW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_366755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700409.1">
        <property type="nucleotide sequence ID" value="XM_024844774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWW5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWW5"/>
    <dbReference type="GeneID" id="36552474"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366755"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="4">
        <location>
            <begin position="676"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="989" mass="111181" checksum="4C242ACC78DBB331" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX44</accession>
    <name>A0A2I2FX44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_366906</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700512.1">
        <property type="nucleotide sequence ID" value="XM_024844779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX44"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX44"/>
    <dbReference type="GeneID" id="36552479"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366906"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="283"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB45210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="948" mass="107393" checksum="DB41A6C9BAFEAC9E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXH7</accession>
    <name>A0A2I2FXH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_479857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700642.1">
        <property type="nucleotide sequence ID" value="XM_024853727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXH7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXH7"/>
    <dbReference type="GeneID" id="36561425"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479857"/>
    <dbReference type="OrthoDB" id="4482003at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37569" checksum="FB03239920AD2F1A" modified="2018-02-28" version="1">MSSPSGQIGAAVVPPRDQIDYGPQGTFKLDLSNPPTIEGLERKLKGRENYDMWCNRVRIVLKPLHYFQLLDSSIPRPSIDDAEDFKIWLKHSEWTVYWIKQQLSDDMLNQVEMSSGASEYADELWDELRRLCVGSGSRRSESLLLNAIHCDRNKFDSLAAYIKGFQQAVEVCSTIHCPITPWMATLILLDGIRNELPVFYDLTHHSLKDDMATTMEWSHFKKIADEAVLSANQIINTSSAAPAAKGRKGKNSPTNAPPVENTSSSFTYPPRKPENGMRDYTLAEKWRNLPEDKKMVDKVCAYCKIRGHKTTNCFYLAPHICPDDWLPVEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYF8</accession>
    <name>A0A2I2FYF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_457965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700973.1">
        <property type="nucleotide sequence ID" value="XM_024851755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYF8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYF8"/>
    <dbReference type="GeneID" id="36559454"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457965"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="59354" checksum="6BAEDEA151DD708C" modified="2018-02-28" version="1">MTTLPLLRGNSIALEDALTDDDNILHRLDYPRKQKEFWERLVSHKSEIEELVSFHLGAKHCRIGAEEDWMFGSYNVCIPVEVNPPSDERVLIRNPLPFKIGEPNFPGNADEKLRCEVVTYIWIRENAPSVPIPILHGFGFPGGQTFIKPSCVSLFSRLRWQLTQAARWWLGFPTCPYISLRRSSALPTGYIIISFVKNGRMLSETWRTHLLEDQTRRRTLFKDLANIMLSLNRTHLPQIGSLTIDDDGVIQLDRRPLTLRLQTFENEGIPTIPRDSTYQSVEPYILDLLQCHDNRLIHQPNAIHDVNDGQEQFAALTMMRGLLHQFISRQYRNGPFVLTLTDLHPSNIFVDEDWHVTSLIDLEWACFFPIELQTPPYWLSGRPIDDIEHGEHLQTFEKIITEFIEIFDEQEKRLEGSNAFQVGVMKECWERGSFWYFQAVHSPKGLLRVFNEHIQGRFCEEHCTQRVFDQTVSPYWSAYSESFIQRKDKEETEYKDRLRKRFADSMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYJ7</accession>
    <name>A0A2I2FYJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_478653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701012.1">
        <property type="nucleotide sequence ID" value="XM_024853580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYJ7"/>
    <dbReference type="GeneID" id="36561278"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478653"/>
    <dbReference type="OrthoDB" id="3796275at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="136" mass="14891" checksum="B4C661CD13EFB800" modified="2018-02-28" version="1">MVTSIAEHPEKLSDQEPLSNLLVGPGHTISDATHQKYFLGPLKPWTSFDADVRARSDTTHWSSHVLLFRHRYQTPAASLKIEHVRCGDETGVQGRFVANVGQVLSAACAASNTDLRFGDFKATALSLSRAITNIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ32</accession>
    <name>A0A2I2FZ32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_478820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701190.1">
        <property type="nucleotide sequence ID" value="XM_024853595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ32"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ32"/>
    <dbReference type="GeneID" id="36561293"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478820"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="260"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="742" mass="81299" checksum="1EDEA0C64C059E8A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZD5</accession>
    <name>A0A2I2FZD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_257967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701290.1">
        <property type="nucleotide sequence ID" value="XM_024843061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZD5"/>
    <dbReference type="GeneID" id="36550760"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_257967"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="151" mass="17186" checksum="64C98C169E4B36E8" modified="2018-02-28" version="1">MKERALDSLRRFRRLGWPWMEEERRSAPRSATILILASPSTLNTATRSENNFQFDRPQSHSLCSQASVPHSDPESTGWLVRPGDEGMLNVLEIFPPSSRGWTKHHRRGKVKAPPKKNFVIKTFFPSAFFLLGCLAAWLDIITFIGPEATHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0T0</accession>
    <name>A0A2I2G0T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_427808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701792.1">
        <property type="nucleotide sequence ID" value="XM_024847800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0T0"/>
    <dbReference type="GeneID" id="36555499"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427808"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="30937" checksum="4D250494A7D4400C" modified="2018-02-28" version="1">MLEFARGTRAIQQNKWPRGGLRAPATSSGTPSPYGDDWDMLWLGFCGIDSREGERRFYIIPDDPTVPPVPRREDFKHPLLADNSQMQQARIVFDAVGGVCTSGFAVTCDAARKILAQLSMSPLNEPVDVAYGAMCDYKGPEDNFCCLAPYPPLISSWRQTGSSERDSDIYYTGDEWHEAYSEGIVYSTMLNAQRLANGERTFLAQWEEAEPLEIDPSDFVSPRGFLYEREIPDSRPTISNSVIPVDSTVTLGYTDSSVVSAAPSPTSIRHRSLNEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0U1</accession>
    <name>A0A2I2G0U1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pectate lyase</fullName>
            <ecNumber evidence="11">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_427815</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701799.1">
        <property type="nucleotide sequence ID" value="XM_024847801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0U1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0U1"/>
    <dbReference type="GeneID" id="36555500"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427815"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB46497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="268" mass="27340" checksum="D4AB387F0587AE7D" modified="2018-02-28" version="1">MKFEIAAVIAASAIASAAPASSSAAPSSSPAPTSAAVSGSVTTKLPASSGTSTLSAVKTIAAGETFDGGMVAYDRGVSCTGQEEGDDSDAVFEIENGGTLSNVIIGPNQIEGVHCFGACTLTNVWWSSVCEDAFTIKEQADGETTKITGGGAFKAEDKVLQQNGGGTLEVSGFYVEDFGKLYRSCGNCDDMPTRHVVLDNVYAVEGKQIAGINANYDDTATLRGVTVSGVDDVCVTYEGNSDGSEPEESGSGPDGTNCKYSESDVTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1D9</accession>
    <name>A0A2I2G1D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_477570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701997.1">
        <property type="nucleotide sequence ID" value="XM_024853484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1D9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1D9"/>
    <dbReference type="GeneID" id="36561182"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477570"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="357" mass="38592" checksum="CC5215441039EE8D" modified="2018-02-28" version="1">MTAALPLTRGALIIQGPNTLRWLTSVAIPEITADEILVQTKAVALNPSDWKMVANATVTPGPISGGDFAGVVVKRGNDVGGIEVGDRVFAYVFGANPAHPSHGAFAEYVATCPDLCFRMPPFMSFETGASLGLGLMTVGLVFKSFGLRPFEPPSPNSRTKPYVLVYGGSTATGTLAIQLFKHHGFVPVSTCSPRNFELVQRLGAEAVFDYASPTCKEDIRAYTKGELEYAMDAIADSRATTICYGAIGESGGRYTALESYPERLRGRRKKVKPDWVLCPTIFGERIDLAGSYQRVAQPEDREFAIRWAAHCTALLETGKLQAHPIQVQPGGLQRVANGLDLLRKKQVSGKKLVYPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1I1</accession>
    <name>A0A2I2G1I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_428027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702036.1">
        <property type="nucleotide sequence ID" value="XM_024847820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1I1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1I1"/>
    <dbReference type="GeneID" id="36555519"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428027"/>
    <dbReference type="OrthoDB" id="5402033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="722" mass="83012" checksum="1A419D9AA369A6C9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1S8</accession>
    <name>A0A2I2G1S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702128.1">
        <property type="nucleotide sequence ID" value="XM_024849618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1S8"/>
    <dbReference type="GeneID" id="36557317"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438531"/>
    <dbReference type="OrthoDB" id="4480817at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014193662" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="10507" checksum="6DCF61CFA3DF1545" modified="2018-02-28" version="1">MQLKSLLVLAASFSLATADYYVGNCGQGPDSTKEAPTKSACSAVEGTLCTGTGITRCVVDTGRWSDFTSACKKEGFDKTYQRPGSVGDLSTAKSLAACPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1T6</accession>
    <name>A0A2I2G1T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_438543</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702140.1">
        <property type="nucleotide sequence ID" value="XM_024849620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1T6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1T6"/>
    <dbReference type="GeneID" id="36557319"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438543"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB46838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="531" mass="61286" checksum="937EDAA3191662DE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G271</accession>
    <name>A0A2I2G271_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_363301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702271.1">
        <property type="nucleotide sequence ID" value="XM_024844569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G271"/>
    <dbReference type="STRING" id="1392250.A0A2I2G271"/>
    <dbReference type="GeneID" id="36552269"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363301"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="273" mass="30349" checksum="1242819B3C48303E" modified="2018-02-28" version="1">MWVVSFWIFPVISACMWIAMLVAMLGHWAVVGSPIYSSMEPGQTIAYISDVGAQELKPLFIAGSVVTVVFLDLSFIAERWLRHAGQLVPNKGVFDKACAIGSIFFSIAGALGLILLSCFDTVRHPHKHVGFLVMFLVGYLISAILICAEYLRLGIFYRSHHRVLFASFVIKAFFVVVEIGLAIAFGVLGREGGRKRNAAAVLEWVIALIFTFYVLSFVVDLLPSVRTRRHVPQGEKRINMAEPSPELTHEEPLTMDSAGPNANNVNYYRGQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G296</accession>
    <name>A0A2I2G296_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_457399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702296.1">
        <property type="nucleotide sequence ID" value="XM_024851716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G296"/>
    <dbReference type="STRING" id="1392250.A0A2I2G296"/>
    <dbReference type="GeneID" id="36559415"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457399"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="209"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="279" mass="30456" checksum="0A751F6C4FE2431E" modified="2018-02-28" version="1">MSRPEDVLPPDLFYDDNESRKYTTSSRIRNIQADMTNRALELLDLKSPSLILDLGCGSGLSGEILSQVPTEHGGPHTWVGMDISPSMLDVALQRGVEGDLFLADIGQGVPFRPGSFDAAISISAIQWLCNAETSDVSPEGRLRRFFEGLYASLRRGGRAVCQFYPKNDAQRSMISGAAIRAGFGAGILEDDPGTKNSKLYLVLTVGGGGLQGDITGVVHDMDDVNVLDARKRAMENGRASTSKKGDRAWIMRKKEQMTKKGKIVKSNSKYTGRKRRPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2J3</accession>
    <name>A0A2I2G2J3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_438809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702388.1">
        <property type="nucleotide sequence ID" value="XM_024849689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2J3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2J3"/>
    <dbReference type="GeneID" id="36557388"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438809"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="235"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="733" mass="83504" checksum="021F759B9403483A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G335</accession>
    <name>A0A2I2G335_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_388728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702587.1">
        <property type="nucleotide sequence ID" value="XM_024845849.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G335"/>
    <dbReference type="GeneID" id="36553548"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_388728"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="609"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1584" mass="174024" checksum="F50CD785D014E26B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3C3</accession>
    <name>A0A2I2G3C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702678.1">
        <property type="nucleotide sequence ID" value="XM_024849751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3C3"/>
    <dbReference type="GeneID" id="36557450"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439054"/>
    <dbReference type="OrthoDB" id="4462505at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014128249" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="87" mass="9228" checksum="2732DCDAF3028435" modified="2018-02-28" version="1">MRLSITSIVLSLCVLPSIASPMPAPAENSALMSKRCCILCDNPYARCGSNDKREAFETEEGAISGLGKRCSINSMNPAFRCGSAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3X6</accession>
    <name>A0A2I2G3X6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_194832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702888.1">
        <property type="nucleotide sequence ID" value="XM_024842727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3X6"/>
    <dbReference type="GeneID" id="36550425"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_194832"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="276" mass="29245" checksum="352E351D76AD4413" modified="2018-02-28" version="1">MAFARRLAILPGGLGGLGSSIGKRLREQGARLAVLYAPFEASRRDQLLSEGYGATHNRDEIRAYECDITSPESVQSAFTTLETEMISPSSSSVSDRVFPSILVNTAGYVSLSDMELTPPDETTKHLTTNVLGPMLCSQAFAKLYFAASKAAESSTSPPAPGRIVNIASQAAHVALHRHGAYCASKAALLGLTRSMASEWGGRGITTNSVSPTVAWTALGKKAWGEDSVREAFLKNIPTGKFALPEEVADAAVFLCQDSSGMINGADIRVDGGYTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4Z7</accession>
    <name>A0A2I2G4Z7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_510658</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703257.1">
        <property type="nucleotide sequence ID" value="XM_024854798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4Z7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4Z7"/>
    <dbReference type="GeneID" id="36562504"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510658"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB47955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="124" mass="13776" checksum="3666AF62AB2EDDE6" modified="2018-02-28" version="1">MAASAVSFKERQFLAVIGDEDSVTGLLLAGIGHVTDGPDAERNFLVVDAKTETSAIEKAFQNFTQERKDIAVVLINQHVAERIRHSVDTFAEPFPAVLEIPSKDHPYDPEKDSVLKRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G524</accession>
    <name>A0A2I2G524_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose/galactose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_447807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703287.1">
        <property type="nucleotide sequence ID" value="XM_024850919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G524"/>
    <dbReference type="STRING" id="1392250.A0A2I2G524"/>
    <dbReference type="GeneID" id="36558618"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447807"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="17204" checksum="F29C9469252B8FEF" modified="2018-02-28" version="1">MSADPKPLRIVFACDEAGQPYKETLKAALEKNPLVDSIQDVGVNSTSDKTAYPHPAVAGAKLIKEGKADRGLFICGTGLGVAISANKVPGIRAVTAHDSFSVERSILSNDAQVLCFGQRVIGIELAKKLANEWVTYRFDPKSASAAKVQAISDYETQLAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5C5</accession>
    <name>A0A2I2G5C5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">P170DRAFT_510772</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703381.1">
        <property type="nucleotide sequence ID" value="XM_024854811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5C5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5C5"/>
    <dbReference type="GeneID" id="36562517"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510772"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="226"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="763"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1027"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PLB48079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1177" mass="129491" checksum="715DC5DC7DF711E3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6N7</accession>
    <name>A0A2I2G6N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_477150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703839.1">
        <property type="nucleotide sequence ID" value="XM_024853424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6N7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6N7"/>
    <dbReference type="GeneID" id="36561122"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477150"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014165633" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="156" mass="16778" checksum="EFEDCCBD4B3FC882" modified="2018-02-28" version="1">MKLPSLLTLALASTTTTLANPVPNPDANTNTNTLSKRGVETVYLSNCITSGSVYNRSGMFYYPDGDQSQNGERPASGNYASVNGGSLVFWEGKSVFGTFGTGVTFTSSINAGSHSAFSYSGSGTNGYRTFSCYRDNERFLFNSASWGNCYSIYYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7R7</accession>
    <name>A0A2I2G7R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_464502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704224.1">
        <property type="nucleotide sequence ID" value="XM_024852253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7R7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7R7"/>
    <dbReference type="GeneID" id="36559951"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464502"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="35"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB48922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="355" mass="39018" checksum="98EF42D89266926A" modified="2018-02-28" version="1">MLRFRTEGYNGCAVKYSPFFDNQLAVASAANFGLVGNGRLFILELTPNGIVPVKWFTTQDSLYDLAWSEIHESQVLAGSGDGSVKLFDSNLNDFPVQNWKEHNREVFSVNWNLVAKDRFCSSSWDGTVRVWSPERPHSLITLPTHSCTYSAAFSPHSPDILSCVTSDSYVRLFDLRTPASASNHLVMQIPIHAAPVPTVPGTPGVPPAASPPSECLTHDWNKYRPSILATAGVDRTIRTFDIRAPQQGPQAVMVGHDYAIRKLSWSPHLSNILLSGGYDMTCRAWSDQSPSGVVGDTDMMHAGPAPVMGAELGRMNQHSEFVTGVDWCLFGSEGWCASVGWDENLFVWDVRAVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G845</accession>
    <name>A0A2I2G845_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_323256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704361.1">
        <property type="nucleotide sequence ID" value="XM_024843329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G845"/>
    <dbReference type="STRING" id="1392250.A0A2I2G845"/>
    <dbReference type="GeneID" id="36551029"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_323256"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="244" mass="27269" checksum="6272718C68822591" modified="2018-02-28" version="1" fragment="single">LAITATMTFLASVFVLLRFLARRKTSVQLDDWICLASLTVAYGFLVATALMVTIGQAGHDQSSYDRHTRQVSIQSYLATDILATSCLSLTKLSILLSYRRIFVVKPAFRRATWVIGGLVFAYFVSANCVVIFPSKPVEDESHTRHSYNAVWVAFCSLNLALDITVLCLPQSIVWRLKMTRQRKIQLSLVFLLGAFVCVASIVRIYFVSELDMDNLTYSLLSVANWNAIEMTTGIICSCLPMMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8P1</accession>
    <name>A0A2I2G8P1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704547.1">
        <property type="nucleotide sequence ID" value="XM_024853271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8P1"/>
    <dbReference type="GeneID" id="36560969"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475548"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="105" mass="11722" checksum="9311717F2426F71E" modified="2018-02-28" version="1">MIHDGSAISALLILGSQGDHRSKTLEGLRFQNRTEPTGDEHRQKWQPIRALSDPYVLCACRRPTMAWLPPRQVPGTSGVRRQQPINTGKGTLTSHFEFLGIVDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G988</accession>
    <name>A0A2I2G988_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_437015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704744.1">
        <property type="nucleotide sequence ID" value="XM_024849270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G988"/>
    <dbReference type="STRING" id="1392250.A0A2I2G988"/>
    <dbReference type="GeneID" id="36556969"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437015"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="312" mass="34418" checksum="F8F4D314A6BF787C" modified="2018-02-28" version="1">MFSSLQSRSGGPYASTTASLGELPSITPDIPVSAVFIAIFIAFAATNMTILQVNLRRNHKFVLSGAMFGFSMARITTLVLRIVWASRQHNVRLAIAAGIFVNAGILVIYIVNFILSQRILRAKQPHVGWNPIYRVLCKVLYFGIFAALVMVIAAMVVSVYTLNPHTKTICRDIQLAALTYFLVFSCLPFLHVAVTFWLPRSQDEETFGEGSMGAKTIIVLLSTGLCVFNAGFKAGVNWSPLRPITSPGWFDSKASFYVFIFVFEVLILCLLTFSRIDKRFFVPNGCKGPGDYTQLREKSSKADGDDSGSQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9H5</accession>
    <name>A0A2I2G9H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_475821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704832.1">
        <property type="nucleotide sequence ID" value="XM_024853291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9H5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9H5"/>
    <dbReference type="GeneID" id="36560989"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475821"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000102">
        <property type="entry name" value="Folate carrier protein Flx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="222"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB49530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="311" mass="34056" checksum="1C0C06A3136B0138" modified="2018-02-28" version="1">MTGQDGLSSSLVETVAGFTAGIVSTLCLHPLDLVKTRLQVDRSSSSRLGGSLRVVRGIFHQEGGITAFYRGLTPNVIGNSTSWALYFLCYGNVKDLLRASRLSSGQELTSSDYFLASGTAGMLTSILTNPIWVIKTRMLSTGSRMPEAYASFTSGAAQIYRSEGIPGFYRGLLPALFGVSHGALQFMAYEQLKLRRARMYHVSMPGGDHPTASQRRELGNLDLFVISSLSKICAGCVTYPYQLLRSRLQTYDAHVVYRGVWDAVVQIGSKEGIAGFYKGLGPNLIRVLPSTWMTFLVYENTRAYLPGLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9I4</accession>
    <name>A0A2I2G9I4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_437115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704836.1">
        <property type="nucleotide sequence ID" value="XM_024849290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9I4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9I4"/>
    <dbReference type="GeneID" id="36556989"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437115"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="157" mass="17152" checksum="358F67E162EC4436" modified="2018-02-28" version="1">MAAERTNFSSDLVWQITRNQNSFLVKRNSGGGSQFSRDPLNLQNKHSFKYAGYANNKAIGVQPFETNGVSVITKKPGNPQQPAKNVVTVNYGAGASNRKIYKGVADKSAKNGYRGDIREDAVARVSAIRRAQKAKKETPARKPRGAQAKKAAEKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA02</accession>
    <name>A0A2I2GA02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_314577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705008.1">
        <property type="nucleotide sequence ID" value="XM_024843273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA02"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA02"/>
    <dbReference type="GeneID" id="36550973"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_314577"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="33199" checksum="D4B9298276EE6321" modified="2018-02-28" version="1" fragment="single">GFGGSHTAGPHTSNTANELDPRVDSDRSSYGHSSTKPLSNSTSGYGANNSYGSSYGNNTTAGPHTSNVANEMDPRVDSDRSSTGFNRSHQGSVPGNGLGHAGGTSGYTGASGYDRTTGPASSTAGPHTSNVANEADPRVDSDMSSGRNFSTHDRTTGPASSTAGPHSSNVANEADPRVDSDLDSTGARNSVSRTSRTTGPASSTAGPHSSNVANEADPRVDSDMSSARHSTTTGSTNANTKGAHINTSLPNALGHEGNIRGSITGQATEGMDPRVDSDRDNRARHEDMASSSYNTPGSGRASGTAGPHDSNVGNKMDPTVDSDMDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA77</accession>
    <name>A0A2I2GA77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_437284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705086.1">
        <property type="nucleotide sequence ID" value="XM_024849328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA77"/>
    <dbReference type="GeneID" id="36557027"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437284"/>
    <dbReference type="OrthoDB" id="4487527at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="51" mass="5876" checksum="02A85E62DEDF0B4C" modified="2018-02-28" version="1">MDKSSSQNKDSAQPDLAQYQAQWTKIHNDTIKQIKQIREKEQAKGSDKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA80</accession>
    <name>A0A2I2GA80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_510249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705087.1">
        <property type="nucleotide sequence ID" value="XM_024854759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA80"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA80"/>
    <dbReference type="GeneID" id="36562465"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510249"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="43"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="706" mass="77558" checksum="737AA6286603C1A0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAU8</accession>
    <name>A0A2I2GAU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_473569</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705300.1">
        <property type="nucleotide sequence ID" value="XM_024853058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAU8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAU8"/>
    <dbReference type="GeneID" id="36560756"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473569"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014193586" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="87"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="157"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB49998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="275" mass="25249" checksum="1F361F9266405B54" modified="2018-02-28" version="1">MKTFSLSMALLAAASMVSAEISVGQCARMCINNMNDKASELGCDKGDLACLCNADNYKFGIRDCTSQACPDDDSNKVVNIALNACPDSSSAGSSGTSTGTASDSTATGTKSGGAGAGATGTDATGTATGTATGTATGTATGTGATGTGATGTGASGSGTATGTATGTNSGSVTGTNTNSGASSTATGGSQTVSNTTGTGATGTTMSTATSTGGSGSGSGDDNGSGSGSDSDSTGSGSSSTETAPSSSETADSAAAHNVISGGALGALGLAALLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB11</accession>
    <name>A0A2I2GB11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_435288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705376.1">
        <property type="nucleotide sequence ID" value="XM_024848906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB11"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB11"/>
    <dbReference type="GeneID" id="36556605"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435288"/>
    <dbReference type="OrthoDB" id="4509259at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="89"/>
            <end position="102"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="128"/>
        </location>
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    </feature>
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        <location>
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            <end position="249"/>
        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="397"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="540" mass="54828" checksum="DFFA6A33582D622E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBA0</accession>
    <name>A0A2I2GBA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_137281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705458.1">
        <property type="nucleotide sequence ID" value="XM_024842445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBA0"/>
    <dbReference type="GeneID" id="36550142"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_137281"/>
    <dbReference type="OrthoDB" id="4315400at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="476" mass="52868" checksum="950891BF785555E0" modified="2018-02-28" version="1">MDLKDYVSHEPFHLQSMGAITTCSPSPISLPLLSPSQSQSQSPFPSSCHPDPALQSSSLNHVMNNFYPEPVALSLHNYRKYLAHGGSSTSVDGHDFKKLRRKNAALNLNQPSDPPHSVSPFSVSSASSPPPLSPSSSPSAVSELGAESLRGFLLSPSPVDWGSGERSGHRLDSYKILNTFRDRLEQYPDPDPTPSIRGHSKTYSDSALLNVPQDDSTVISHNGTSFEILNPHESLRFARIVSYIEDVDTYSVPSSSGHGHQRDSYLFDDTNSIPIYDTSFLDDDDHRSFPYPLEDTHEEDISPDVTAHHDLVGDSPHHPMPSISERLEENDVESTYSPDDPRRNSYSFPYPPSPTSPSHSRSYSYSHFHRPSRLWTPRSFDSSDLGEPGSPVCEDDYNPHTSWKPSPGYPRSLDAEVVITRSGKNEIHVQRRPTQRSSNRPAKGGPEASKTGPFRRLCVFAMAWRRKKFFGGEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBH5</accession>
    <name>A0A2I2GBH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Ran-interacting protein Mog1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_435427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705530.1">
        <property type="nucleotide sequence ID" value="XM_024848930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBH5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBH5"/>
    <dbReference type="GeneID" id="36556629"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435427"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="218" mass="23678" checksum="A6581919DBFFDA5F" modified="2018-02-28" version="1">MATYVTQGFYGSTIEGVIPQGWIDASTLREVPDHQEIYLSPKTLTSQIIEINQRVDTADALAFHTPSSSSTTPTADDIDRSAVLYHLHDLCDDTDTLNVTNPPQPVTLPNLPQARAYRGVVALTSPRKQRRGDVGQSVGGAVAGSSAEGSLTSTTSCYYLLVRLEEQETDVLVFVNVPREEFENVGDARGLAEEEKLAEGLVSGLVEKLRIVDWGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBV5</accession>
    <name>A0A2I2GBV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative citrate lyase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_435540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705647.1">
        <property type="nucleotide sequence ID" value="XM_024848961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBV5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBV5"/>
    <dbReference type="GeneID" id="36556660"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435540"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000023">
        <property type="entry name" value="CitE, Citrate lyase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="323" mass="34615" checksum="B95C05D972E57054" modified="2018-02-28" version="1">MASRNTLRRSLLYIPGSSQRFIDKSRSLAADCVAYDLEDSVTPHKKAEARSLVRRALEQPSPGGIRERAVRINSVDSGLALADLTEVLQSPNLSTIVIPKVNSASDLTFVSDVINHTLAQQAASNPSAGATRPPISLLALIESAKSLTNLTQITAATPYLQGLIFAAEDFALDLSLTRTPSLTEFLFARSSIATAARAVNLPSTIDLVCTAYKAQGGEAATVLEDECRSGKQLGFNGKQCIHPSQVETAERVFGPEQGEVTWAVRVVVADEKAARSGRGAWTLDGKMIDVPVAEKAKAIVRKAEECGMDVGALREEWKGQEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBY7</accession>
    <name>A0A2I2GBY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolases or acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_508553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705659.1">
        <property type="nucleotide sequence ID" value="XM_024854589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBY7"/>
    <dbReference type="GeneID" id="36562295"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508553"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF4">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="369" mass="39916" checksum="404EFF6E059E63E7" modified="2018-02-28" version="1">MQLKFPQHLPPGKAHPGILHQYTPHLVAFEYTHVDRPKPHTLVFIGGLSDGLNTVEYLADIVSALRDSPWSVFNVVLSSSYTGWGLGRLGQDIDEIAKCVDYVRSYKGGVYPAGSEAGSGNTGSGKVVIMGHSTGSQDVMSYLSQGNPRPRHEVLDGEGDGEYERVCRGAVDGAIMQAPVSDREAILSVLEDGTERDTPETMRRVYDDAVRDAMRNTYDYGNGDGAAPLGTDTLVPLQVTARIGYGASTAVSSRRFLSLASPRSPEDPTEDDLFSSDLSDEQLGRTFGTIGTRGLLTGRLLVLYSGRDQSVPGYVDKEALMGRWEKAAGEMWDSGSMVIPGASHALSDDDQAEPRRILVERVMGYLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCJ6</accession>
    <name>A0A2I2GCJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative hexose carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_355032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705887.1">
        <property type="nucleotide sequence ID" value="XM_024844069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCJ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCJ6"/>
    <dbReference type="GeneID" id="36551769"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355032"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="505" mass="54943" checksum="DC6822B16032126F" modified="2018-02-28" version="1">MVSRYVVLIALVVALGGFVYGVDSGIIATTLGHDSFKYYMFGPSGKNAALTGAIVSLYNVGQAVGTFGAGYSANRFSRRWTICASAVIAIIGTILQTAAVNPGMMIAGRFLAGVGCGILLAVVPIYIAEVSPPKQRGMIVGLQGFMISIGFFVANWIGYGGAYAKDDAQWRIPLAMQIPGPVALTIGCCFIPYRPRWLIQQERYEEARAVLEKLHVSENDEDVVLRELAQIREQIHTETEHVTSFSSAITSLLSPRYMHRTLMACFILSMGQFSGSTVIQNYQNNFYATVGFTGKTSLLISGIYGIMGVLGQVIYLCFAADKWPRTRTLWVGSIFLCVMIAICMALSAMYGDKSNGSLTGARAAIAMIFLYSCGYAVFFNATIWVVPSELFPFFLRSTGMGLAVFCKSVSAIILSQITPTALQNVSWRYYALFIATNFAAAFVYFFLLPETSGKTLEEIAELFGDGVAKSPSKQVDDSCDKDAPSEKQATLETNDPRSAHVERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD30</accession>
    <name>A0A2I2GD30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_455213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706085.1">
        <property type="nucleotide sequence ID" value="XM_024851509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD30"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD30"/>
    <dbReference type="GeneID" id="36559208"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455213"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="505" mass="57483" checksum="0F6202886A5A85A1" modified="2018-02-28" version="1">MVHLSRVRKAKHPHREPEESGDTSSAPYVYATHYAAEELPEHEIAEREMPAAVVKRMIQDELSLDGNPLLNLASFVTTYMEDEVESLMTDAMSKNFIDFEQYPQTAHIQNRCVNMIAGLLHAPTNNDDDSDQDSIGTSTVGSSEAIMLGMLAMKKRWQNRRKQEGKDWTRPNIIMNSAVQVCWEKAARYFDVEEKFVYCTDTRYVIDPQTAVDLVDENTIGICAIVGTTYTGEYEDVKKINDLLIQRDMDCPIHVDAASGGFVAPFVNPDMVWDFQLEKVVSINVSGHKYGLVYPGVGWVFWRAPEYLPKELIFNINYLGSDQASFTLNFSKGASHIIGQYYQLLRLGRHGYKSIMSNLTRTADYLASELEKLDFIIMSERSGRGLPLVAFRLPGDDSRLYDEFALAHVLRRRGWVVPAYTMAPHSNQLKMMRIVLREDFSLHRCNLLIEDFKMAIKTLDEMDESMIDRISQYIQTHGAKMPHNPLYANETHSLQGKTGKSHPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDV4</accession>
    <name>A0A2I2GDV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-polyprenyl-6-methoxyphenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_382200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706355.1">
        <property type="nucleotide sequence ID" value="XM_024845596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDV4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDV4"/>
    <dbReference type="GeneID" id="36553295"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_382200"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="417"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="635" mass="70773" checksum="F597D7C743D3564C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GES0</accession>
    <name>A0A2I2GES0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetoacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706681.1">
        <property type="nucleotide sequence ID" value="XM_024847649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GES0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GES0"/>
    <dbReference type="GeneID" id="36555348"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425611"/>
    <dbReference type="OrthoDB" id="10248817at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="245" mass="27307" checksum="C9A3977C3ABF9362" modified="2018-02-28" version="1">MPFGSLPVDGTPIPQYAPPYSTQGNEYSDMTMLIVTYRTKADNVRPLVPDVLELEDEPLVTAMLLSHGMSTFGTYQEYVHAVEVTYNGERFDYNLSLILENEAAIFCGREQLGYPKKFGPVSLMLETGSRVIQGQAEYPAGQKVVQFNYSPIRRLKEVTFPAKRSLNLRVIPSAIPDQPSSVKELIPFAVDFVSDEAWEGSASISFPEPSDFHPMHRVGVLRYESAILVRRGTCAIHAATEVFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF09</accession>
    <name>A0A2I2GF09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706758.1">
        <property type="nucleotide sequence ID" value="XM_024848496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF09"/>
    <dbReference type="GeneID" id="36556195"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433443"/>
    <dbReference type="OrthoDB" id="3538998at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014133792" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="34179" checksum="C012DA02A6E1F615" modified="2018-02-28" version="1">MRFSTSVLLGLLAANVSIAAKVGKFDADKCADPSGLKTCYDKAKSTYNDCVKKNCDKEENGKTVDDPDCLDKCACTRDRARIDCAASSCWNQVYSCEYQLTVSDLAETCDKPDLDNIPFYPAPDNAPGGCSCAVGKVNKAMLEATKIQGNQCDLKSSASDSEIEECMCCGYSAILSSLPDTCPNTKLSELSIDDLEAAIEQAGWKDCASTLEKVDCAKKFSYPKLDTYYKPGKLPNGTATLSNTGSSSITSPVSGATFTWTAGSSDHVVTAQSTDAAKATGSSASATSGDSASGTASASATATTGAAVRVGMDSYLFAGLAVAAVFVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF94</accession>
    <name>A0A2I2GF94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_471485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706852.1">
        <property type="nucleotide sequence ID" value="XM_024852843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF94"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF94"/>
    <dbReference type="GeneID" id="36560541"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471485"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF81">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="582" mass="64672" checksum="FBAE1B3669EE7336" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFK5</accession>
    <name>A0A2I2GFK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA damage response protein RcaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_487772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nibrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706919.1">
        <property type="nucleotide sequence ID" value="XM_024853962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFK5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFK5"/>
    <dbReference type="GeneID" id="36561663"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_487772"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000082">
        <property type="entry name" value="DNA damage response protein RcaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="698" mass="78294" checksum="E7417B17E9D80778" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFQ0</accession>
    <name>A0A2I2GFQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_83650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707008.1">
        <property type="nucleotide sequence ID" value="XM_024855410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFQ0"/>
    <dbReference type="GeneID" id="36563117"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_83650"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="109" mass="12893" checksum="2F4C86C5D292554A" modified="2018-02-28" version="1">MISASARRLHSPFWLICYFIFVLCVWSFLVCYAALCFLSMLVPITNCLWSTPVFCQLRCHLEAGTLASESHLFDYGFPLSIQSAESEYTNVFFFFFFFFFLSFFWFDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGD7</accession>
    <name>A0A2I2GGD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_401593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707199.1">
        <property type="nucleotide sequence ID" value="XM_024846378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGD7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGD7"/>
    <dbReference type="GeneID" id="36554077"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401593"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.105:FF:000007">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase accessory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="29"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="479" mass="53121" checksum="A827CEC27A0827D9" modified="2018-02-28" version="1">MDPEAPSQSRDEMLSFSLLNPTSASTLTPRLGNLAIAGRNPISTPHYIPLTSRGAVPHVAHDVMLKQTAIGSLYFGLEDFIEKQNQKNKSLPIYQVPTESHESALRKFTCFPEDLLLVLGPRRVPPIPTPPMNTDNSIAIMTAFGFRQLDANQYVEAVQNLRPDIVVGLADLVVGQRPGYKRRGKMVDRTHAFAMHATENLYGQAVSEENRSKTAYFAPVLPLDNAEQMIYLDELESDLRPHISGLALYEPESLSVLPETLGSLPRLLFGQPATPQDVLREVSLGADLLTVPFVGVTSDAGVALEFAFPPPCPTEGSASEARPLGFDLWSSVHTFDTSPLVEGCQCYTCRNHHRAYIHHLLTAKEMLAWTLLQIHNHHTMDVFFQRIRESIQRGTFEAEVQAFQRFYASELPKQTGQGPRLRGHQITPSKAHQPRRNPRGFGRLDDALEKFAESQSSVATPDTDAEGLEAHGFAKKQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI57</accession>
    <name>A0A2I2GI57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707867.1">
        <property type="nucleotide sequence ID" value="XM_024852950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI57"/>
    <dbReference type="GeneID" id="36560648"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472452"/>
    <dbReference type="OrthoDB" id="4526869at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="162" mass="17859" checksum="2A069543927E7335" modified="2018-02-28" version="1">MANVIYATVSVSSVNCVQENVRPTVIAVDEAGRVAEPKFWLMLVEFQPIACLPRPSLRDTRSTRHRQPNVGHTPTTSPRACTGQCKVAIVLNKPSDPRKETRITPDGPRTPPNTTIMPNWDDTASTGSAVDRAEETTEETKKKTTETKDKKRAPDHRPDEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIC8</accession>
    <name>A0A2I2GIC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_434312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707899.1">
        <property type="nucleotide sequence ID" value="XM_024848687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIC8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIC8"/>
    <dbReference type="GeneID" id="36556386"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434312"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="509" mass="55805" checksum="A2803A71832A3B47" modified="2018-02-28" version="1">MALWGIAYAAGPNYNKAWRYFDPADLRASIQRASDAIAHAATLPNHLTTPVERALVSAIAARFPSPDRIPDDLAPFDRAYADAMRPVYAQFGTDPDIAALFADALMCMTPRGLWDLDTGEPTGPHTVEARTVIERGLASATGRSHPALCHLHIHVMEMSPTPELALPAADRLRYLVPDGSHMLHMPTHIDAAVGDYRRAIDSNHEASVADDKYFATETGTISYMGYRVHYICAKLYAAMMCGRFADAMAAAEKLEEVITDEVLTITSPPVADAIESFLGSKAHVLIRFGRWEEILRLEVPGDRELKCATAAVVLYARGLAYSALGRIDEAEATRREFEDARSAVPESRLNSIPCKQVDVLGVSSAMLHGELEYRKGNYEVAFAALREAIRREDALPYSDPPPWMQPVRHALGGLLLEQGRVEEAEVLFREDLGFAKGFPRRRAKLNNVWGLHGLHECLTRLGKTDDLLFVESAHAIAVATADVPIVASCYCRLSAVESGCCSEKSGCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIM1</accession>
    <name>A0A2I2GIM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_403164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708023.1">
        <property type="nucleotide sequence ID" value="XM_024846463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIM1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIM1"/>
    <dbReference type="GeneID" id="36554162"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403164"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000030">
        <property type="entry name" value="Coactivator bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="154" mass="16760" checksum="83B7C3FFD34A56A1" modified="2018-02-28" version="1">MSDWDSVTRIGAKNRGGAAPRETVVKGKSALNAAQRQGLVIGTEKKYASGNTAGRSAAVEGQHLTKVDRSDDIVKPKTVGYQVADAIKKRRNEEGYKMTQKELATKCNTTPGVIQDFEKGTATPDQKVLSAMERVLNVKLRGSDIGKERFPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIX9</accession>
    <name>A0A2I2GIX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_472723</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024852974.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1392250.A0A2I2GIX9"/>
    <dbReference type="GeneID" id="36560672"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472723"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="98"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="467"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="746"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB52833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="914" mass="94942" checksum="4C05B3ED80952340" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ17</accession>
    <name>A0A2I2GJ17_9EURO</name>
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        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">P170DRAFT_444762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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    <dbReference type="GO" id="GO:0071540">
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003743">
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="eIF3e_N"/>
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        <property type="entry name" value="PCI_dom"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="256"/>
            <end position="425"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="451" mass="51485" checksum="1826FFA9759C1707" modified="2018-02-28" version="1">MAANAPPSAEALLSGAAAHPPKTAEEIANQYDLLPKLIPYLDRHLVFPLLEFSSGQDDDKEVVRAKYELLKHTNMTDYVANLWSEINNSDTIPDEFVKKREEVLAKLQHFQEESAKITDLLQDESVVGNLRSDKVANLKFLEEQHGVTTEMVNSLYDYGRFQYSCGSYGNAAELLYQFRVLSTDNDKVASATWGKLASEILTTSWDGAMEEVQKVKDSIETRLFNNPLGQLQNRSWLIHWSLFPYFNHDPARDVLTDLFFSPAYINTIQTSCPWILRYLAAGVITNRTRVHKNSSMYQKQLKDLIRVVRQEGYEYTDPITDFVKALYVDFDFEEAQKKLGEAEDVLRSDFFLVSAADAFVEAARHLISESYCKIHQRIDIKDLSTRLGLNQDEGEKWIVNLIRDTRVDAKIDYKEGTVIMNHPPQSVYQQVIEKTKGAFFRTQVLSAAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ25</accession>
    <name>A0A2I2GJ25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708139.1">
        <property type="nucleotide sequence ID" value="XM_024852975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ25"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ25"/>
    <dbReference type="GeneID" id="36560673"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472731"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="323" mass="35754" checksum="70124929BF63EC2E" modified="2018-02-28" version="1">MRELVNNLPTQTIVGLSPTTDEAYAAFMKSIDSPAHTVDLENGTRGHWIGDSFAEHVLFHCHGGGYAVYATSAHFEGLWNIVQELRHGGKSLAVLLLSYGTTFVFLTPSRYRLTGVGIDVSSTARYPRQLQQASSLLSYLVQTKAVASSNIILTGDSAGGHLLLSLLSHIIHPHPEVPPITLPPETVFLGAALLSPWVTFDTESSDSIKRNRAKDVLHIPSLELWSARFTGTAPRDNYIDPLRAPPEWWVGLPIRDILIVSGADEIFVDDIDVFARKLSAVHPTVSHFSASGEAHIQLFTEFMIRESKSKQRDVLQKWIRDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJL8</accession>
    <name>A0A2I2GJL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_423840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708366.1">
        <property type="nucleotide sequence ID" value="XM_024847531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJL8"/>
    <dbReference type="GeneID" id="36555230"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423840"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="326" mass="36892" checksum="56BC6E544C464645" modified="2018-02-28" version="1">MWEVPTEYILDGRRLKLGSGKAARAAQRVTNDLEDWSPGANAPDFDRFVWVEGEKVGHLTPFTITKPTKSQDLNKIDWARRVTAPMPLRVINKLMRQGILDPDGPLSPVLPKFKERMVWVGLEYFRSRPQGIELRDLTDDALRFFALVLSYAKASGSCSGRSPKFSTSIMPRTDFATMFRLANLDNILRDKSFYEIVKIASCYEIDKTGHIKRVISIDPRYSNGTLEEPLPNNKLDTAQFVIGEAKINVRDWLEGIQHGTDILSEFDADHGDTQIGALGMRTERVFGRQELAPIFVFRNLGSSKKEAFARDVQEAEECVIRLHMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJY7</accession>
    <name>A0A2I2GJY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 18">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="18">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_454341</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="18"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708500.1">
        <property type="nucleotide sequence ID" value="XM_024851425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJY7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJY7"/>
    <dbReference type="GeneID" id="36559124"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454341"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 18" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="157"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB53198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="308" mass="34251" checksum="34FD5715E9AB08FA" modified="2018-02-28" version="1">MLSSLGNPRQSLAQVLNFALVLSTAFMLWKGLSVFTASSSPIVVVLSGSMEPAFQRGDLLFLWNRSPRAELGEVVVYNVKGKDIPIVHRVVRTYPEVEGKAKKVKEVSESSPAPNNMLLTKGDNNLADDTELYAPGQDYLNRAEDIVGSVRGYIPGVGQKRIAKELSELIESPPDGISVELADESNIYEWKVYMDGPEGSPYHKGRFLMKLSLPTEYPFKPPAVSFGTKIYHPNVTNDEKGSMCLGMLKSDEWKPSSRIGAVLEFARQLLAEPMPDDAVEGRIAEQYKNDKSRYEEIAKDWTRKYATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK22</accession>
    <name>A0A2I2GK22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_348433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708538.1">
        <property type="nucleotide sequence ID" value="XM_024843675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK22"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK22"/>
    <dbReference type="GeneID" id="36551375"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348433"/>
    <dbReference type="OrthoDB" id="5431405at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="10">
        <location>
            <begin position="518"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="606"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="750" mass="75865" checksum="27D2F81F7F33BB4D" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK83</accession>
    <name>A0A2I2GK83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_445071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708584.1">
        <property type="nucleotide sequence ID" value="XM_024850677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK83"/>
    <dbReference type="GeneID" id="36558376"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445071"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23135" checksum="7BCC3B493A3CB6C6" modified="2018-02-28" version="1">MATPFLDLQGNPISQDQVLGNSALVLLQDGVAVKTPLRCLWSNPSDVEGNLQSLRREQDVYCRLQSSDDDRLNGSRPSHELQLSWCLEMACIFSYIHDLCVLVADIVSRNSLLDSNLFLKFCDFSEASLLPLGSHMEAVDDTGFTTQIDIGLLGAVMHEIVTGESAKIDLFRDTFFTDGRAYRPKREYLPETSDIWLGWIIEGCWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKF1</accession>
    <name>A0A2I2GKF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoepoxydon dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_349800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708653.1">
        <property type="nucleotide sequence ID" value="XM_024843762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKF1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKF1"/>
    <dbReference type="GeneID" id="36551462"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_349800"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="259" mass="28057" checksum="D7909B4AD6AB1524" modified="2018-02-28" version="1">MPLETGLKGAHVLITGGTRGMGQSMVHEFLKEGANVSYCARTVTNTEYDDFHQTLPADNSARAVGTALNVASKEAIVDWVKASADRVGRIDVVIANASPMHMEGETHHWQESFAIDVMGFVELVKAAEPYLEKSPQASVIVQSSFMGREFYRSPPAAYGPCKAAQLQHVQELSHYLGPKGIRVNAISPGPVLCEGGPWEKYSKLMPEWVEEQRQKIPLKRLGGPQEIANVAVFLASPLASFVTGTNILADGGIHVGTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL44</accession>
    <name>A0A2I2GL44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708902.1">
        <property type="nucleotide sequence ID" value="XM_024848034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL44"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL44"/>
    <dbReference type="GeneID" id="36555733"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431425"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="313" mass="34381" checksum="A240B09B82EBB427" modified="2018-02-28" version="1">MEPPESLVDIGSHRLFLSLQGTPRALGSPLVVFLAGAGDVCVSFGAVARVVGQFAPTMLYDRSGLGRSQDGPDPPRATTAARELRRLQERAGLEPPFLLVAHSYGGIVAREYLERYPDAVAGLVLVDAATEQQVELIDDEHRQAINAVMGDVNFARVIGLRDGARLSRDEWRTRAAGIARGLSTWQEEAAAVHEICETLGRKDQYRRHILGMKPLAVVRARSSLDYERIYAAGVAAGHGTDAQRTTFRQLLDRWDSVDGAMQKAQLQLSSTHRFIDVPDCGHHVHLIRPELVATQVQWVLDGILSSNQPLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL84</accession>
    <name>A0A2I2GL84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_431472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708946.1">
        <property type="nucleotide sequence ID" value="XM_024848043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL84"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL84"/>
    <dbReference type="GeneID" id="36555742"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431472"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="144"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="365"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="636"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="700"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="943"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="943"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1059"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB53644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1118" mass="122553" checksum="894A359B80B6672B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLA8</accession>
    <name>A0A2I2GLA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative C2H2 finger and ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_431494</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708966.1">
        <property type="nucleotide sequence ID" value="XM_024848050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLA8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLA8"/>
    <dbReference type="GeneID" id="36555749"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431494"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000290">
        <property type="entry name" value="C2H2 finger and ankyrin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="13">
        <location>
            <begin position="223"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="542"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="545"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="599"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB53664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="638" mass="71697" checksum="82974D93916B5A85" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLB4</accession>
    <name>A0A2I2GLB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_347374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708973.1">
        <property type="nucleotide sequence ID" value="XM_024843626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLB4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLB4"/>
    <dbReference type="GeneID" id="36551326"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347374"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF5">
        <property type="entry name" value="BLR2277 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="3">
        <location>
            <begin position="45"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="310" mass="33807" checksum="B32062DD33801EB3" modified="2018-02-28" version="1">MNFYPVPPVIQTETYIRIPDSIRCTGQPTEWRGGSATPMADIFLEGPTYVSNGDLYLVDVPYGRILKVNPDKEVTECVRWDGEPNGLVVRGDGCLVVADYKQGILLFDPSTNEISPLLTRRNLERFKGPNDLIVSSTNDIYFTDQGQTGLTDQTGCVYRLSPTGKLDCLVSNGISPNGLALSPDERFLYVAMTRSNAVWRLPLHEDGTTTKAGLFFQSFGNAGPDGLAVDEEGNVFICHPSLGSVFVVDADGVPKARIVTAPEGGKNLTNCTFGGPDHKTLFITDSIKGNVQFVRWHCEGVPRSRATKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLV5</accession>
    <name>A0A2I2GLV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709159.1">
        <property type="nucleotide sequence ID" value="XM_024848082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLV5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLV5"/>
    <dbReference type="GeneID" id="36555781"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431643"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF1">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014144761" evidence="1">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="277" mass="29878" checksum="902EB94BBAE10AA3" modified="2018-02-28" version="1">MHLRSFLLGSALASSTLAFGINDFSCRSEKHPNPVVLLHGLGATFYEDLNFLQYWLQAQGYCTFAQTYGDYDGFPFLGGLKAIAESATEIADYIHEVAEKTGADKVDLVGHSEGAFQTVYVPKFTDGTSELLDKLVAIAPPTRGTNFGGIYNLAYAFGNHSREAVGEVLKTVGCAACDDLGPDGDAVDKLNDGEPIVQAGNKLTVIASKLDEMVTPTSTSFVHEDGVNNVWVQDDCKLDPVGHIGEAYDLNVWNLVKNALDDTPKRKFFCVLGSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLX7</accession>
    <name>A0A2I2GLX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_431652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709176.1">
        <property type="nucleotide sequence ID" value="XM_024848085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLX7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLX7"/>
    <dbReference type="GeneID" id="36555784"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431652"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="351" mass="38268" checksum="F37DCB890E8BC273" modified="2018-02-28" version="1">MPSPTPTPRTALVTGANGYIGNAVCRAFVRAGWTVYGLTRKTESIPSLAREEIIPILGSPGDLAFLPTLLSQQKAFDAIISTTESLYDYESHFAEIMALLHSLSSSNNASGIRPLVLFTSGCKDYGMTARADSPNLAPHTESSPLNPPDVLSPRTYTSLKVFDDEHKAAFDAVLLRPTTVFGRSGSFYGPFFDMAQAAKEGDGVLRLPAHRESVVHGTHVDDCADAYVAIAERDRTVVAGQIYNISGWRYETLAEVGEALVQEYGLQGVVYEPPATEGFVGFDVIGVLTGFSQWVGSEKVRNDVGWRDKRQLFSVGIKGYRIAYEQAVREGHSNVLRVKGYVQAYQSTKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM81</accession>
    <name>A0A2I2GM81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_451889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709294.1">
        <property type="nucleotide sequence ID" value="XM_024851233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM81"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM81"/>
    <dbReference type="GeneID" id="36558932"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451889"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="369" mass="40790" checksum="F2DEDEEA9984B8E4" modified="2018-02-28" version="1">MANRPPALDKHVFCIKDLREAGNKKLPKAYRDFHDDGSMDMLTLKENETAFDHYKIRPRVMVNVDDIDTSTTLFGSKVSFPLGFSPTGMQKLAHPDGELATSRAAANTNLGMVLSSYSTVAMEDVIAQGQENPYAIQMCILRDRSFALKLLKRAEEAGFKAFFLSVDFPLIGQRLNESRNEFVLPEHMSWPNLNFGGDSFFGGGGGTSYDSSMEWREFIPWLRANTTLPIWLKGITTKEDVELAIEYGADGVVISNHGGRQLDGAPAAIDALRECEPIARGKIQIALEGGIRRGSDIFKALALGAQHCFVGRVPIWGLAYDGQNGVELAMKLLHRELKTTMALAGCRTIDDIRRSHISVLQADRVLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMD0</accession>
    <name>A0A2I2GMD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_469503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709335.1">
        <property type="nucleotide sequence ID" value="XM_024852641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMD0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMD0"/>
    <dbReference type="GeneID" id="36560339"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469503"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000626">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF84">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB54033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28859" checksum="E49A46CB4F2BF8C9" modified="2018-02-28" version="1">MATPSSGRTHTKLTGTPDYDDPQYWDTKFATGRDVGEWLNPGESLVDAVVSDLETRSSFAVDATPRVLHLGPGISKLGLKLRDAFTKRQWPGNGIVNVDFSAEAVRLGREAESKEDASHAMHWLRADLRSWDDMSALSSLGPFDVILEKSTSDAIATGPSPCFSPETAPADICPTVRRILEHNGVTTMSPVELLGLHLAALTRPGATWATLSYSAMRFDNLGLLTEYWEQVSRTPVKAPQGETSAFAFTPEVFHWIYILRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN42</accession>
    <name>A0A2I2GN42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_431897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709572.1">
        <property type="nucleotide sequence ID" value="XM_024848143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN42"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN42"/>
    <dbReference type="GeneID" id="36555842"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431897"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000240">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000011">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="250"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="538" mass="59233" checksum="4B036E3BBE0D1A0D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN86</accession>
    <name>A0A2I2GN86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_421066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709635.1">
        <property type="nucleotide sequence ID" value="XM_024847339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN86"/>
    <dbReference type="GeneID" id="36555038"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421066"/>
    <dbReference type="OrthoDB" id="5409271at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="200" mass="21005" checksum="64EDC6647E4A7E66" modified="2018-02-28" version="1">MLPPSDSLLHHAHKLSEAAANIDRNDVRPTPPPPYSSAAQHNAIHEDIESELAGDEDRQAPLAIYVDASINVSGDGNSIVLPPSAAEAASPSSSASAGNATAHAAPRQRQTRLTDMTASILTALHRTGLLNAARTSTPVEIHVTTGIKIEGSRNIICSGSVANRPLVGKRHAPGDEASRKRRSQSEPTEVPGSSKRHCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN98</accession>
    <name>A0A2I2GN98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein get1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="11" type="ORF">P170DRAFT_431981</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN98"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN98"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431981"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB54354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="199" mass="22631" checksum="D42D4B371AE56421" modified="2018-02-28" version="1">MLSLIWTVFFVHVAIYLVNTIGASIIDNLLWILYMKLPTATSKNAREQNRLKREALQLKREMNNTSSQDEFAKWAKLRRRHDKAMEEYEAMNKTLTSAKTSFEWTVKIARWLSTNGLKIFLQFWYSKTPVFALPEAWVPYYVAWILSFPRAPMGSVSIQVWSNVCATTISALAEIVTIAVQAGVGKTRPAPAATAQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNH1</accession>
    <name>A0A2I2GNH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_343975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709712.1">
        <property type="nucleotide sequence ID" value="XM_024843437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNH1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNH1"/>
    <dbReference type="GeneID" id="36551137"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343975"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="47"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="304" mass="32891" checksum="5E3E2958E7008C8F" modified="2018-02-28" version="1">MLFSRVRTVPRLRIAPRSSRRQSPPPKLAATFSTTASFRYAAHREPNYYDILGVPVTASGAEIKKQFYSLSLRHHPDRNRDDPTASERFARISSAYNVLGNHTKRATYDRDHGILAHHMSTHSTAAPGQHPMGSYSSHSANLHNTGASYAGSRPASGLSKRRGPFRGPPPSFYAHGGYGNRKPPPGAGFGAAGAGGAGAGAGASGRVHEDDPTSFIDRNPVYHFNARGHHRTQTAEDVRRQQRRSREMGSATTDQYIGTSGDFAMRFIVVCGMLVVTAGLAGITRSSAEKGSRVGKPIARRKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNH5</accession>
    <name>A0A2I2GNH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ATP dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_432077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709737.1">
        <property type="nucleotide sequence ID" value="XM_024848183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNH5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNH5"/>
    <dbReference type="GeneID" id="36555882"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432077"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="171"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="407"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB54435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122496" checksum="C94BAF642EC2B774" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP43</accession>
    <name>A0A2I2GP43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_432275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709947.1">
        <property type="nucleotide sequence ID" value="XM_024848228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP43"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP43"/>
    <dbReference type="GeneID" id="36555927"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432275"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF105">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G08790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="147"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="30520" checksum="F22EA68C6EAB844C" modified="2018-02-28" version="1">MSCPDCFSGHIHAGSPQGTVTFLHGLDVYVAEPSAGADAVRGIIIIIPDAFGWEFVNNRILADRYAEKGRYKVYLPEFMNGRPAPTWLIGTMRSLMKTDSLLAWLTKPYHLVWAASAFLPFIYYNKFSLSWPVVRSFFAAVRQNEGAGLPIAAAGFCWGGKHTVNLAHGAEVDGKPLINAGFTGHPSLLELPGDIEKITIPTSFAMGELDRVVKMPQVMQIKDIVETRNGVGEVKVYYGAGHGFCVRADTALDNADKQAVEAEDQALDWFNRHFAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPG9</accession>
    <name>A0A2I2GPG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_470217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZPS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710076.1">
        <property type="nucleotide sequence ID" value="XM_024852727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPG9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPG9"/>
    <dbReference type="GeneID" id="36560425"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470217"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11307">
        <property type="entry name" value="M35_Asp_f2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000043">
        <property type="entry name" value="Major allergen Asp F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014147626" evidence="5">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="291" mass="31917" checksum="2953FD7022D888F4" modified="2018-02-28" version="1">MPSFISLLLLSTVPAIAVPAPILPRASDSQTLPHKSLSPWDAGAVNLYPIHQSCNATQRLQIETGLNETIALADHAKAHILRWGNESAIYRKYFGDSPSIEAIGAYDIVVNGDKGGVLFRCDNPDGNCDLDEWAGHWRGSNATSETVICDLSYTTRRSLTTLCSQGYTVSSSKPNTFWAADLLHRLYHLPAIGQGLIEHYADDYEEVVELAKGDNSTLATKDSNTLQYFALEVFAYDVVVQGEGCSGDDGEEDSHDDGKGEEEKEEKKEDDEEEDIPENCHTHEGGELHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPV7</accession>
    <name>A0A2I2GPV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_398674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710205.1">
        <property type="nucleotide sequence ID" value="XM_024846239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPV7"/>
    <dbReference type="GeneID" id="36553938"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398674"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="530" mass="60381" checksum="FA0010DF359D0CC5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPX8</accession>
    <name>A0A2I2GPX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_348043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710232.1">
        <property type="nucleotide sequence ID" value="XM_024843664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPX8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPX8"/>
    <dbReference type="GeneID" id="36551364"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348043"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="605" mass="65601" checksum="D0B8B0303B13A48B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR72</accession>
    <name>A0A2I2GR72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_375067</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710663.1">
        <property type="nucleotide sequence ID" value="XM_024845306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR72"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR72"/>
    <dbReference type="GeneID" id="36553006"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_375067"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001619">
        <property type="entry name" value="Beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190828" description="beta-glucosidase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="17">
        <location>
            <begin position="776"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="722"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB55361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="866" mass="93413" checksum="4FB39675257789CB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRC4</accession>
    <name>A0A2I2GRC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_506026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710729.1">
        <property type="nucleotide sequence ID" value="XM_024854340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRC4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRC4"/>
    <dbReference type="GeneID" id="36562046"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506026"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000542">
        <property type="entry name" value="Putative rnp domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="255"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="378" mass="39548" checksum="7A12A362F45E005D" modified="2018-02-28" version="1">MSFPPPPGLNQTPSSLPPRPPPPASTASSASRQPAYSAAPSYASSGTSSGYGGNGPRPGYNAFTAFQPRTVASSQSYRTNSPAVSAPPAASAGYSTPTTTTGYGSYYSQPQQTYQGGPSYYGSAQYNENSYGPSVPHIQNPFAPGGEHGPRGKNFGRNESGLDPEMEAQIAQWQSAYANKDEASSMGKIPGRPDRNPAMPGAPSGANTPSGSTPTAATPVPMPGHSEQNPKTVARSGGGQNWTDSTLLEWDPAHFRLFVGNLAGEVTDDSLLKAFAKYTSVQKARVIRDKRTQKSKGYGFVSFSDGDDYFRAAREMQGKYIGSHPVLLRRATTEVRPVSNSKNGKKNGGSGGGHAGGKVKHDGVKKPGKTKGGLKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRC6</accession>
    <name>A0A2I2GRC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF829-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_470851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710738.1">
        <property type="nucleotide sequence ID" value="XM_024852791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRC6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRC6"/>
    <dbReference type="GeneID" id="36560489"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470851"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27004" checksum="D39D4675400E3AC8" modified="2018-02-28" version="1">MPSPHKIPTFTPLSPSTSIYIPATTTAKTTTKPSTITPPPHLILLCTYLNASPAHIIKYVTGYKRKFPTSRILLVTTSSSHFLVQSAAQWTREFEPAVGSQARGSEGSWWWWWFWGKVKALAIVAGLRVYFAVWFLLERLMGVENVVGVVRRLNDPAQFSADLTRLYIYSGKDELVRAQEVEDHAEETERKGYEVLRLRCLDSGHAGHLLQDEEQFWRSVPGLWGSRILSSPGMVVCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRX6</accession>
    <name>A0A2I2GRX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_375458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710915.1">
        <property type="nucleotide sequence ID" value="XM_024845316.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GRX6"/>
    <dbReference type="GeneID" id="36553016"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_375458"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22448">
        <property type="entry name" value="KH-I_ScSCP160_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22449">
        <property type="entry name" value="KH-I_ScSCP160_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
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        <property type="entry name" value="KH_dom_type_1"/>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="210"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="292"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="386"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="540"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="711"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="778"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="868"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="945"/>
            <end position="1021"/>
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    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="1218"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB55613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1295" mass="140431" checksum="3C988156614B8414" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSA9</accession>
    <name>A0A2I2GSA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_443478</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
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        <property type="protein sequence ID" value="PLB55759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024850551.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GSA9"/>
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    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443478"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DEXDc_SHPRH-like"/>
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    </dbReference>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PI3_PI4_kinase"/>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="171"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="1250"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1603"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="1713"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="623"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="781"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB55759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1889" mass="212373" checksum="9FC0C999D1F1022E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GST0</accession>
    <name>A0A2I2GST0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_471319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711228.1">
        <property type="nucleotide sequence ID" value="XM_024852828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GST0"/>
    <dbReference type="GeneID" id="36560526"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471319"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="246"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB55926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="418" mass="46944" checksum="15B9E418DDB83B45" modified="2018-02-28" version="1">MPTLTELAEEALANARRLDAYTAAQGLPLVSLDDDTLTRAELPAELQTTRSALVDSAQMMKRLAQGPLLNMTEMLFSFTDIISIQAIYRYDLPSQVPLTGTASYEDIARAVSLPEGICRRFMVHAMENGIFEEVEGRVKHSAFSRMLAEDREAMQAIGMMVVDLIPAGHRTLDALARWPASCEQTETGFNLAHDTNLPLYAFLSQDPGRISRFGTGMKFFSRGGGFDLKFLVMGFPWAEIDREDALVVDCGGGVGTVSRRLAESTEKMHFVVQDMAGPVALGQQTLPAELQDRVRYEVGDFFAEQKLVGADVYFFRWIFHNWSDAYCVRILRNLVPAMRAHSKVVIYEYILAEEPELKWSRKQGRNLDMVMMAGWNAEERSMSQLSRVFAQADERFVLEGSWQPEGSTMTAISFGWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQB0</accession>
    <name>A0A2I2FQB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_132635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000026">
        <property type="protein sequence ID" value="PLB42799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_132635"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="120" mass="13206" checksum="2A1E9817927F4247" modified="2018-02-28" version="1" fragment="single">MLDSLVRVSRRVVYNHYASVRAEARSSVQAGSIAPPAIRCPKGTTFRGFDLPPKPTLARPRGSTPARMPAEPAGESGRKRFPFNNFTCFLTLFSKCFSSFDHSTCALSVSGQYLALDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQH1</accession>
    <name>A0A2I2FQH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_371157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000020">
        <property type="protein sequence ID" value="PLB42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698186.1">
        <property type="nucleotide sequence ID" value="XM_024845083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQH1"/>
    <dbReference type="GeneID" id="36552783"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371157"/>
    <dbReference type="OrthoDB" id="4231495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="69" mass="7740" checksum="DF0F508A32F7F53B" modified="2018-02-28" version="1" fragment="single">RRRRGSWEGYLFFLTAYHPEIGLSGARVPWLAEPCTFAGSGAPPTTLENPREGIVFTPGRTHNRSRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR91</accession>
    <name>A0A2I2FR91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_514406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698429.1">
        <property type="nucleotide sequence ID" value="XM_024855204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR91"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR91"/>
    <dbReference type="GeneID" id="36562910"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514406"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB43127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="384" mass="41770" checksum="F6771667C850322E" modified="2018-02-28" version="1">MFPSQTVSLDLDALSGICGSISIACWVVVFSPQIIENFRRGSADGLSLLFLVVWLAGDVFNILGAVLQGVLPTMIILAVYYTLADIVLLGQCFYYRGFTLKDEPSSPPPAQDDTENADPTSERTALLSSKPNGSSYQSNGTQNQHGNGHVTSTSTSTAQPPLDHRRHSAASSTFRDILHPSVDGTHLSPATPFIEPSPKQTAPARHISTIQSILFNVSAILLVCAAGILGWYVSPGSSKNKGDEQPPDDNSLSFDTWGQVFGYFCAVLYLGSRLPQILLNYRRKSTEGVSLLFFLFACIGNLTYVLSILAYSPVCRGDALEQTNRCRPGETSALYGRYILVNLSWLIGSLGTLFLDMCIFVQFFLYQDSGYTENEPTDQGSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRG0</accession>
    <name>A0A2I2FRG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_394638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698498.1">
        <property type="nucleotide sequence ID" value="XM_024846064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRG0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRG0"/>
    <dbReference type="GeneID" id="36553763"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394638"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="261" mass="28108" checksum="3B0A4070A49648BA" modified="2018-02-28" version="1">MASALRILVPVKRVIDYAIKPRINKAQTGVETAGVKHSLNPFDELSIEEAVRLRERKGPLKVDNILALSAGGAKCADTLRTAMAMGADRAFHVDVADSNDGGLEPLTVAKMLKEVVNKENINLVLLGKQAIDGDQGQTGQMLAGLLGWPQATQASKVDVKDDKGTVEVTHEVDGGVETLRAQLPMVITTDLRLNEPRYASLPNIMKAKKKPLEKKTLADLGVEDKRRLKTLKVTEPAPRQGGGKVEDVNGLVSKLKELGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRG4</accession>
    <name>A0A2I2FRG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_419048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698525.1">
        <property type="nucleotide sequence ID" value="XM_024847260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRG4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRG4"/>
    <dbReference type="GeneID" id="36554959"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419048"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07625">
        <property type="entry name" value="BAR_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="129"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB43223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="590" mass="65124" checksum="3E0454AB91C768AE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSP2</accession>
    <name>A0A2I2FSP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_450843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698928.1">
        <property type="nucleotide sequence ID" value="XM_024851149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSP2"/>
    <dbReference type="GeneID" id="36558848"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450843"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="427" mass="46654" checksum="A40C3B0D111BAF96" modified="2018-02-28" version="1">MTATDTIDGGYGWVIVFAVFWNNAHVWGILSSYGVFLAYFTSHSVFPHSRALDFALIGGLSTSQALVISPLITTIHRRFGLRATIGLGVLFETAALLGASWSTEIWQLYLSQGVCFGWGLGLQYLSTTAIIPQWFNKRRSLAAGITTAGTGTGGLIYSLAAHAMLDNVGRNWSYRILAIVQFVVNSICLLLLRDRNSTRPSEKPGRSINFKLGKRYETWLFIAWGFFSVMGFMVIWFSLATYARSIGLTASQGSTITAVMNVGQMFGRPAVGFSSDRIGRFNVTTFASFVSGVLCLLLWVFARTYAALTCFALFAGILFGTFWTAVGPLAAEVVGLDELQSCLTIAWLVCSVPATFGAAIGLELRTTGEHEYLHTQLFTGFMYIAASICTLLLRGWKISANDPSAPESRMGNNGEDMLRATVRLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSV7</accession>
    <name>A0A2I2FSV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_480668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699011.1">
        <property type="nucleotide sequence ID" value="XM_024853802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSV7"/>
    <dbReference type="GeneID" id="36561500"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480668"/>
    <dbReference type="OrthoDB" id="4430287at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014197727" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37086" checksum="40029210A83F5B8E" modified="2018-02-28" version="1">MAVIHRCLVLLLGLGISLANAQKLHHSCAELKGKNSEGVETNYGDVRGSIAVAIQEVGAIAETARDYMSKAAENSGDDFDIKRTVNSFYAFQGEKDGAEMSSQGRWNLALRNLETIKDYVDNRNTRDPPFLCGDGHLTKFTHYENGERIQAQDHDGNAFDTYMYFDGFSGEWWAIAEPACEDDPGTIAITHPGGYIQVCPSAFSFAQMTAPRDTIDSDKSEDSKIDWSDKEYEGDYRQSLDYWATPLSYSMFHELTHFLLGYDDYKISEPVSWIGGTVDKAYKFNGATQLVKEDIDKVPNNVDNLGMMALSLFMKSCNWSSGRARGKESKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSX4</accession>
    <name>A0A2I2FSX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_459339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699023.1">
        <property type="nucleotide sequence ID" value="XM_024851861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSX4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSX4"/>
    <dbReference type="GeneID" id="36559559"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459339"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="447" mass="43844" checksum="9065DFF5A89104F8" modified="2018-02-28" version="1">MPPPPPPPPPPPGAMGGPPPPPPPGGLPNRPSKGEVKDRGALLSDINKGTRLKKTVTNDRSAPVVGGGGAKSSGPPIGGAPPVPVMAKPPGGLAPPVPPAGAANRLRSNSETGSGGGDSSAASAPAVPQLGGLFAGGMPKLRSRGGGVDTGANRDSPYRGENDAPRPPVASAPKPPGARPPPPPPSSESPPAPPVNPLVNNLRKPPPRPVSRPSSTVSTQSGKSAPDAPPPRAPPPLPGAAKQPPPPPVSLRKPSAPAPPPPPPPSTSPAAPPPPPPTARPPPPAPARSTPPPPPAPPASAPPPPSGAGAASIAVQAARNALGHSPQTPSAPPPPPPAASAPSAPPPPPPSAPPTAPPSEPLSRPSSYEPQAASLDPSAYTLSNGGPSPGSSPRNAGVQGMIPVDDNRFKFQLEGLFPKPRPFTGGIRRYRAGRGSSVPLDLSALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT38</accession>
    <name>A0A2I2FT38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_468565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699107.1">
        <property type="nucleotide sequence ID" value="XM_024852563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT38"/>
    <dbReference type="GeneID" id="36560261"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468565"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="472" mass="50807" checksum="F646F69E238165E2" modified="2018-02-28" version="1">MLQNHETRHLYKEPWSKGRCIVFLPSNPVYPLTMKLIWCSLLGLYLGRSHASPTPPSEDSFYRLPADYETKPPGHILDHRPLPHPLKDPLPSFFETGHQIIYRTTDSFDQPTASLATLLIPPNANLSRILAYFPVQNSASIDCSPSYVIADGVNEEKTSDRVIELVHTIVLAGALNQGWPVIMPDYEGFGAAFMANRRGAFAGLDSIRAALASSPFTHISADAVAVMMGYSGASPSTVLAAEFQRSYAPELKIEGVATGGILMNLTTVLELAIPAPNNLPPALWGLANEYPPINRVVQAHLAAAGGGAEKTAEFEAARDQCAGALKENFGTANMSTYFDSLDFLNTSAVTRILDENSPGQGVPGAPVLVYESTHDDKSPIGDADALVRNYCAAGVLVDYRKYKVESHTALSVDGMFAALVWAKERFDGVSMGEECRTSDHFSALGADAAAFVPDALTGWVDRHLGTNLGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTS5</accession>
    <name>A0A2I2FTS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_441488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699345.1">
        <property type="nucleotide sequence ID" value="XM_024850324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTS5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTS5"/>
    <dbReference type="GeneID" id="36558023"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441488"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB44043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="245" mass="26906" checksum="13F00BD8C44EEF77" modified="2018-02-28" version="1">MLSQRRIKLLAIGVLAFIIITLYYSGDARRVQNQKFYQSTVAAIEAHRDARNFGTTAEGSSRKEPPNLKQADGTPMKPITDEMKPAIPKEGEEETEEIPIAGRTKMTVTKNRNDAEKQEQVSVADEHVEAKTELNSILKRSPIIIFSKSYCPHSARAKSIILDKYSIVPAPYVVELDQHPLGPQLQALLAENTGRRTVPNVLVSGRSIGGGDDVAALDEKDELASTLKSFGGKWLQGVSHKQADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUB6</accession>
    <name>A0A2I2FUB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_440556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699545.1">
        <property type="nucleotide sequence ID" value="XM_024850104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUB6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUB6"/>
    <dbReference type="GeneID" id="36557803"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440556"/>
    <dbReference type="OrthoDB" id="4892971at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260:SF2">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="104" mass="11925" checksum="089C082863C2D819" modified="2018-02-28" version="1">MVYRAVVMYPNEPDTTFDEAYYKEHHMALVEQIWGKYGIKGWSIQKYTNAMDGSPSKYLIACTLEWESAESLQNAVKDPETPKIFEDIPKFTNKQPITLAGDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUF6</accession>
    <name>A0A2I2FUF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_416766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699575.1">
        <property type="nucleotide sequence ID" value="XM_024847140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUF6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUF6"/>
    <dbReference type="GeneID" id="36554839"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416766"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="360" mass="40061" checksum="83D6D36BE4B569C0" modified="2018-02-28" version="1">MTNKSIFITGASGYIGGSILSNLLRTKEQWATSLHISALVRTEVQAEIVTKLGVSPVMFKSFDELERLEQVGEEYDIIIHAGAGWHTASAKALITGQGRRRQKSRTKVHYFQISGTSNLSDRPHTAGYVNTNLFSDEEDIFSYEKYRESCEVYLQRTTDIAVVETGEAWDVTTYIVMAPTIFGLGSGPINRYSIQLPSLIADALKDGGCSVVETGQTVWSHVHIEDLSTLFVVLVQKIIEDTPIPSGRRGIYFCETGEHTHFEFSERLAKAGFELGLFKSAEVKTISLQLAGDKWAFGNPSRAELAFSSNARTKATIGRQIGWSPSHDGEWESTFHTELREFLKSPPAKRDIPQVLLHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUK1</accession>
    <name>A0A2I2FUK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_480092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699630.1">
        <property type="nucleotide sequence ID" value="XM_024853753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUK1"/>
    <dbReference type="GeneID" id="36561451"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_480092"/>
    <dbReference type="OrthoDB" id="4506810at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014117056" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43738" checksum="337D7EEB469282B4" modified="2018-02-28" version="1">MRALLWPLFFFNTFASPLEPLRELIEDGAPVNSSGQASGLLVKRDWPLQYPGIEFGQKCTDKQKEYVKVQLDEIQVMMEKSISQLDILQDFIATRRQPRTWGSQEGVLTRLYNTWVSYIAQIKFSSGTLPISGGAEPTSWDDTARNVKKLKEIYTKIYEALPEATLDLVIHCSDDFFAYQDDMSTDQRREVPPLESKFESPTERTDEDIVIAANGRLCHESNAVNAWRFQNRVTLKDEICICPNTFQRAGTKNELAHFANNPAQLIDKTLNDMYFWAVAGPLLHELTHSVRVLGDDRTGDQMYTYRSTSLHAYGAHRIGSLAVVHPELSLRNADTVAYFALAMYYSMCDWSKLECAGPKQPQEYWQTTPAGRKYYYYFDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV01</accession>
    <name>A0A2I2FV01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_513596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699698.1">
        <property type="nucleotide sequence ID" value="XM_024855128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV01"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV01"/>
    <dbReference type="GeneID" id="36562834"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513596"/>
    <dbReference type="OrthoDB" id="3548654at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="648" mass="73314" checksum="EEC9D184216DB154" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV14</accession>
    <name>A0A2I2FV14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_287005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699764.1">
        <property type="nucleotide sequence ID" value="XM_024843212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV14"/>
    <dbReference type="GeneID" id="36550911"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_287005"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="347" mass="38483" checksum="CC94E45368E91145" modified="2018-02-28" version="1">MIVCPRCGEFIHPSTNSVTDRCYALETEWRRHQSARSSSQIPPAKNPPPNQALQSMFTRPVDGVLPPVAREPASPSTVNSFPWSHPNNELFPGLPLARRALIGAWIPIPLSASIGEDRQDHDEGHESFTECDCGSRFLRVFASYQGGIIQVGLPRWSCRVLTSWLCFSSVGTRVGWCLFISIFLRSFFLLSSAPPFSVLAIVDFSYVDSFSLSLLLGFICFCFFSFLFLLFDLVRSLFSTSPNGLPQRPNPPGVMVVVAVVEVDTSANLDREQKYQMPPGPIHEAMERIPPRVRTKKYYSHPTPEGELPLDLALGLPSFPLALSGRKHQADLDSAGPGGFHLSLTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVD0</accession>
    <name>A0A2I2FVD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_450646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699886.1">
        <property type="nucleotide sequence ID" value="XM_024851139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVD0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVD0"/>
    <dbReference type="GeneID" id="36558838"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450646"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF5">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="494" mass="52719" checksum="DA206714157BBB69" modified="2018-02-28" version="1">MELTISDYHDALRSGRTTCAHTVAEYLSRIALYNPTLRALITINPNALHDARQKDREGFPHSPSPLHGVPLILKDTYATSSMPTTSGVCALRALTTFDAPVVQRLLAAGAILLAKANLHEFSLEGVTLSSLGGQALNPYDLTRTPGGSSGGTAAALAANLALAGCGGDTVNSLRSPASACSVVGFRPSRGRVDTRGVMPVSWTQDVAGPMARTVRDVRILFDVMKDGEYLGDPAIVPSVKSSSDPVRIGVLIGYFPDESTSDGLAIIQTITHALHLVGSKTPTVEFLPLQNQPDWDVARLRANADTQAYEFQSALDSFLQSPMVKSTPHLSLASVTASGEYHGEAVTPAFWQTQSQTQHHDEKDEEGGEFTPTSPQYRSRLDTIARLKESVTSCFEDLALDALVFPHQRQLVARVGPMVQPGRNGILAALTGRPAICIPAGFSASTDTAPQGVPIGLELMGRVGQDEWLLGLAERFEGLVQGRKAPLDEVYGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVI2</accession>
    <name>A0A2I2FVI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_503445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699878.1">
        <property type="nucleotide sequence ID" value="XM_024854203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVI2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVI2"/>
    <dbReference type="GeneID" id="36561909"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_503445"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="178" mass="20136" checksum="9175932E6B1AA7F4" modified="2018-02-28" version="1">MIIFTDIVSGDEVLSDTFKLQEVDKIFYQCDCRKYLKKQNEDFQLEGANPSAEDGADEGGEGEAVMVHDIEDQFRLVWLKTEEGLKPSKDAFKSHLKNYMKKVLSKLTEKGASKETIDEFKANAPAGVKKILSNYDNYDVLMGQSMDGDAMHILIDFREDGVTPYATLWKHGLDEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVQ4</accession>
    <name>A0A2I2FVQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700014.1">
        <property type="nucleotide sequence ID" value="XM_024849958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVQ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVQ4"/>
    <dbReference type="GeneID" id="36557657"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439961"/>
    <dbReference type="OrthoDB" id="3595585at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58179" checksum="92324AB5BE02A0A5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWI2</accession>
    <name>A0A2I2FWI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_440159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700290.1">
        <property type="nucleotide sequence ID" value="XM_024850010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWI2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWI2"/>
    <dbReference type="GeneID" id="36557709"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440159"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="410" mass="43677" checksum="BA9C532C8F691833" modified="2018-02-28" version="1">MSTQKNIVVLGGSFGGISAAHHVLKHAIPQLADQESHQVILVSPSATAICRPACPRAMISDDLIAQDKLFINIPECFEQYPARNFRFVHGTATGVDQVNRNVSVDLVDGNAETIDYHALVIATGASTRSPLITLLRDEKYLRQNWASLREALPSAKSIVIAGGGPSGVEIAGELGEYLNGRAGWFSCKLENPKVPVTVVTSASQILPDMTPGVAAKAEGFLALVGVTVIKNTRVETVTPADAGTEATVATKTTVTLEDGKTLEADIYIPAMGATPNTSFLPESLLTSDGRVETNTSTLRVDKAGPRVYGIGDATSFGKPSIHNITEALPALGANIKRDLLLAAGKTEAEVGEDKIFKEDTRTSQLVPIGQNKGVGLGMGYQLPSSVVWAIKGRDYWTGMLMKLWNGKQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXC2</accession>
    <name>A0A2I2FXC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_467809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700565.1">
        <property type="nucleotide sequence ID" value="XM_024852493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXC2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXC2"/>
    <dbReference type="GeneID" id="36560191"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467809"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="950"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="970"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="983" mass="111490" checksum="1A298C9871C96A55" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXD3</accession>
    <name>A0A2I2FXD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_416387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700596.1">
        <property type="nucleotide sequence ID" value="XM_024847118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXD3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXD3"/>
    <dbReference type="GeneID" id="36554817"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416387"/>
    <dbReference type="OrthoDB" id="5244622at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="385" mass="42845" checksum="B535EF61E4B1279E" modified="2018-02-28" version="1">MDASRASEPDDHVNSSGSIHSSADEAPPSPTSLPLSNILDSSLDDIHIPILQPVLVRPDARVVEVRVSIPPLALLDDALEDLGTPALEPQRVSSTPVRVSPTQSTPLNWLTRFRFCSERPYKGAKVIPWDGTIHWALKGCSIFENSDEELNALTYRPNLLSQQPIHEVWIFQYGMRYIASTQEKNCYRTVRIEGLPADMQLKQILPSISGEIYCARLVDTRSIIGSNTAIVTFVLQIDAVRLIQSSKNGLDLGLVLAKVVPVNTPTYPMPVEMEKKVFEKNYTRCLCVYGACGFLRDTISRVLMKSRHANALESIEEGHQAGEVYVRFHSIKTAAVACELLKGHPGLFQCQFRFLKQSCAQPRQPAMKAPPPEQSERRACVGIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXH9</accession>
    <name>A0A2I2FXH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_413416</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the FACT complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700651.1">
        <property type="nucleotide sequence ID" value="XM_024846977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXH9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXH9"/>
    <dbReference type="GeneID" id="36554676"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413416"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="15">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="16">
        <location>
            <begin position="542"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="17">
        <location>
            <begin position="815"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="444"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="936"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="938"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="964"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="997"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB45349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1021" mass="115105" checksum="93B6B9967636F602" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXL7</accession>
    <name>A0A2I2FXL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum chaperone BIP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Heat shock 70 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_512079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700680.1">
        <property type="nucleotide sequence ID" value="XM_024854954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXL7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXL7"/>
    <dbReference type="GeneID" id="36562660"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512079"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="638" mass="69665" checksum="F242AD7DA771E31C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXP4</accession>
    <name>A0A2I2FXP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_241664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700658.1">
        <property type="nucleotide sequence ID" value="XM_024842958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXP4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXP4"/>
    <dbReference type="GeneID" id="36550657"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_241664"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="653" mass="74039" checksum="90DA3EE2A0DB30AB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXP6</accession>
    <name>A0A2I2FXP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_364515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthioribose kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700702.1">
        <property type="nucleotide sequence ID" value="XM_024844645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXP6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXP6"/>
    <dbReference type="GeneID" id="36552345"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364515"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34273">
        <property type="entry name" value="METHYLTHIORIBOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34273:SF2">
        <property type="entry name" value="METHYLTHIORIBOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="365" mass="41079" checksum="72A138365B820457" modified="2018-02-28" version="1">MADDLQSLPDVLRRLSYDCTHLERLSGGTANFVFRGTRDHDSVIVKHTKDYIASNREFQLPAERCLIEASILKSLGDFPPTITASSSAGSITVQTPRLLAFDRPSYTQVMEDLPRAVDLKTLLTDPQIAPRLSHPWATSLGAALGQWLGSFHAWTAESAQAVLVREMEGNELMRDLKFNINYENVVGLVDRYPDRLGSSRGVFEEVRDLARSELGRKDGEGGAFGVIHGDFWSGNVLIPKDVFDQQTTIPLFVIDWELAQCGARALDLGQMMAELYFVKHFRDVDAGPWIIEGLARAYPHLTEATAFRVAIHVGVHFICWGTMITDWGTQEQVHQIIELGRDLIVKGWRQERDWFEGGFWGCLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXT1</accession>
    <name>A0A2I2FXT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700741.1">
        <property type="nucleotide sequence ID" value="XM_024849786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXT1"/>
    <dbReference type="GeneID" id="36557485"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439203"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="61" mass="6881" checksum="37157B84FAED3BBA" modified="2018-02-28" version="1">MTRKKSSETFLDPQEVYSAESFVIGWDRSGYTDPYCDAENRSSPLSMILQSTVGVLWETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYA6</accession>
    <name>A0A2I2FYA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_512283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700923.1">
        <property type="nucleotide sequence ID" value="XM_024854976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYA6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYA6"/>
    <dbReference type="GeneID" id="36562682"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512283"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="101" mass="11331" checksum="C139BDC44C6DB53F" modified="2018-02-28" version="1">MLRQSIVRPLSTANRALATRSFSALAPRMAEGDTGAPRAGGSAQSDSFQRREAAQENMYIHEKEIEKLRNLKKSIKDQREHLDKLDQHIDEITKGQGGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYY4</accession>
    <name>A0A2I2FYY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_389894</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701058.1">
        <property type="nucleotide sequence ID" value="XM_024845887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYY4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYY4"/>
    <dbReference type="GeneID" id="36553586"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_389894"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001156">
        <property type="entry name" value="Polynucleotide 5-hydroxyl-kinase grc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="333"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="604"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="756"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="812"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB45756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="845" mass="92675" checksum="2864FD0C580152B2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZI6</accession>
    <name>A0A2I2FZI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_458215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701340.1">
        <property type="nucleotide sequence ID" value="XM_024851776.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FZI6"/>
    <dbReference type="GeneID" id="36559475"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458215"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1120"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1150"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1273"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1392"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="89"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="777"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1422" mass="160131" checksum="2381CAFCD12C01F8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZX7</accession>
    <name>A0A2I2FZX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_458310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701489.1">
        <property type="nucleotide sequence ID" value="XM_024851783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZX7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZX7"/>
    <dbReference type="GeneID" id="36559482"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458310"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="329" mass="37677" checksum="1F40F2A37CADB59D" modified="2018-02-28" version="1">MKIRLLLIVPNLRDSDSAYSGDSLLGDDTKTLSTYITEYRYEFGRRYHSYHDGAYWGPNDEVANEFQDLAHHMYLLTLDGKLHLAPIDSPQEILDVGTGTGVWAVDMADEHPSAKVTGVDLSPIQPVFVPPNCVFEIDDITLPWTYASNQFDFIHVREMFGCVPDWDEFFRQCWRCLRPGGFIEVVEHAVQPTSDDGSMGPDHFYHLWGKTVVQSGEKFGKSFTIWEESAARLKKAGFIGVVETEYKWPMNGWSTDRKLHDLGRWNQLRLHGGIEGYMLRLLTSTLKWSYEQAQVFLAQMRASLRDYKIHAYLPGTVVYAQKPKSPAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G017</accession>
    <name>A0A2I2G017_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_415133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701527.1">
        <property type="nucleotide sequence ID" value="XM_024847049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G017"/>
    <dbReference type="STRING" id="1392250.A0A2I2G017"/>
    <dbReference type="GeneID" id="36554748"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415133"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="82"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="618" mass="69105" checksum="4E71CC508B061611" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G060</accession>
    <name>A0A2I2G060_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine/uridine-preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_479169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701556.1">
        <property type="nucleotide sequence ID" value="XM_024853637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G060"/>
    <dbReference type="STRING" id="1392250.A0A2I2G060"/>
    <dbReference type="GeneID" id="36561335"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479169"/>
    <dbReference type="OrthoDB" id="187522at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264:SF1">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="358" mass="39502" checksum="033DAD7708921504" modified="2018-02-28" version="1">MRWLREIIDEIFELGALRCLAFALAAFAGAWYLEKSSYHEGLIVDTNFFSDAGDAGALLLASTHPDANLLGVNVNYPSVTSALAVKNILGYYGELSVPVGLHPGAQNFTILHRIQVDDGDLAARLMWGWQRYSPRTSQNNDRVPITPSLDMYRSVLARAKRKGITIVSIGFLDDLSDLLNSPGDTYSSLLGYDLVKRKVKELVIMGGQYPFGQESNFLYNPGAAANVVRNWPSKIVFSGSELGRHALSGARLTTEARFGDPVMTAYWWKNGYNRSQESCDPLTMLYAIEGPGEMFEYAGTDGLNSVFLDGINVWVEAKGDYKQAYLKLKVSNETAAARLDDLFVQGAALYAKERPNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0F7</accession>
    <name>A0A2I2G0F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_438187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701677.1">
        <property type="nucleotide sequence ID" value="XM_024849532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0F7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0F7"/>
    <dbReference type="GeneID" id="36557231"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438187"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="94"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="291"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="376" mass="41771" checksum="1A254A87ECE99A0E" modified="2018-02-28" version="1">MSSDLENPPAVASAADPLNLSSKFKRSSDIPAAANSSRKRITASMKSKSKVADFYTQQNEHIERLLKPVHDHVRESRDNEASNQLQYQIAVYGSFVCNIFLSGLQLYGAISSGSLSLFTTMADSIFDPMSNITLILCNREAKKGYTHRFPVGKSRVETAGNIFFSFIMMAVSLILIAFSCQQLAQGGEADFHLPSVIAVTVAFAVKLGLFLYCWALRNTYSQVRILWEDHRNDLFINGFGILTSVGGSKLKWWIDPMGAVILSCLILGLWLHTSIGEFKLLIGVSADAGMLNQITYIAMTHSDSVEAVDTVRAYHSGPQLIVEVDIVMNANLPLHVCHDVAEDLQEKLESLPNVERAFVHIDYEVTHRPEHMKKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1D1</accession>
    <name>A0A2I2G1D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sin3 complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_427976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701979.1">
        <property type="nucleotide sequence ID" value="XM_024847817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1D1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1D1"/>
    <dbReference type="GeneID" id="36555516"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427976"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="857" mass="95226" checksum="358E2D20A046D18D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1E7</accession>
    <name>A0A2I2G1E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_477579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702006.1">
        <property type="nucleotide sequence ID" value="XM_024853485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1E7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1E7"/>
    <dbReference type="GeneID" id="36561183"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477579"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="841"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132379" checksum="0C6C0ACA083DFDE8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G239</accession>
    <name>A0A2I2G239_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_466311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702236.1">
        <property type="nucleotide sequence ID" value="XM_024852408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G239"/>
    <dbReference type="GeneID" id="36560106"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466311"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="376"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="71688" checksum="98BC9A26B524D4EB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2J4</accession>
    <name>A0A2I2G2J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_457487</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702405.1">
        <property type="nucleotide sequence ID" value="XM_024851722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2J4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2J4"/>
    <dbReference type="GeneID" id="36559421"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457487"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB47103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="292" mass="30968" checksum="23F9D2FD1B0756C8" modified="2018-02-28" version="1">MKEERSGGPHLPRIRPSIPNPPPSPSTPSPQPTSPLPFTTLTFATSLDSSLALAPGARTALSGPQSKSMTHYLRSRHDAILIGVGTAIADNPGLNCRIAGVGGYGGEGLTRQPRPIVIDPTARWDLTADSKILALVRSNQGLAPFIITSTRCTPPTAEKQALLESHGGKYIALDPVSQPHDDEEREEGREGASHRMDWTAVLSCLRSQGLRSVMIEGGGSIINSLLGPRAQGLIDSVVVTIAPTWLGRGGVVVSPDRRVDGHGVAIPASRLTDVKWYPLGEDVVLCGRIKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G309</accession>
    <name>A0A2I2G309_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_237366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702561.1">
        <property type="nucleotide sequence ID" value="XM_024842936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G309"/>
    <dbReference type="GeneID" id="36550635"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_237366"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14244" checksum="4259E580872E0685" modified="2018-02-28" version="1">MFHRPGCMETKLPRKSKIDNHRFTWARHALHGSTYAHLFSLLYLLLGLRAWMPERSSLMSCSSMGGGFLVLSLFFAFFFSTFFASSGYFLSAFNPPPNSRSPSLRPVYDVNLTAKPLCPSPRRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G334</accession>
    <name>A0A2I2G334_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_511922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702595.1">
        <property type="nucleotide sequence ID" value="XM_024854937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G334"/>
    <dbReference type="GeneID" id="36562643"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511922"/>
    <dbReference type="OrthoDB" id="5410040at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014190812" description="Alpha-1,3-mannosyltransferase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15316" checksum="600DECEC132A8248" modified="2018-02-28" version="1">MPPHLHPRSRSTTSLFAATLLASLCVVGIPHVFPCPAPRRTLADSQMMVNEDGQPIQRARRRRRKDVPGLDETTPSFTQQTPDDEVSTFLQLEEEAERLAKTGRECPVPKPRGVIGELLGFPSQKDTQLHQAPGREGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3A8</accession>
    <name>A0A2I2G3A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_362924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702663.1">
        <property type="nucleotide sequence ID" value="XM_024844541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3A8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3A8"/>
    <dbReference type="GeneID" id="36552241"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362924"/>
    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="366" mass="40844" checksum="3901C0CC41551ABF" modified="2018-02-28" version="1">MAADSLTIETFTEYALGMCFLLLRLYARVKYVGFRSLGLSDVLAILAMIFWTMQTAIIHLLNIFGNNIGLTQETAMQVPESKVPDMILGSKLAFMNWMWYLSYIWCLKGVLLCLYHKMTDGTSWHRLVHAASIFCVITWLACMLTHICVCTPIPRNWQIKPYPGDNCTLRKPNYVVIAVMNVASDLVCLIIPIPVLAKLQIPIGRKLVLVVLFSSGLFIMICTILRAYYSLKSISTLSIALGWADRECFVAAIVASLPGIKPLFRNTGWFGSTNRGKSGKPTGAYASFGSKFPGTNKTYVSSFGKDTDRFELIERQEKSLATRGSSLGESVEQILPPGEVQDTNRITVTREYILEEDRASPTPGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3K0</accession>
    <name>A0A2I2G3K0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_478302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702755.1">
        <property type="nucleotide sequence ID" value="XM_024853551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3K0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3K0"/>
    <dbReference type="GeneID" id="36561249"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478302"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="522" mass="58157" checksum="E4DBD4452F3AC9B0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3Q2</accession>
    <name>A0A2I2G3Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanine nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702810.1">
        <property type="nucleotide sequence ID" value="XM_024853326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3Q2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3Q2"/>
    <dbReference type="GeneID" id="36561024"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476195"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="409" mass="44503" checksum="55762276A3BC2773" modified="2018-02-28" version="1">MEEEPSKLTPICVASTRDEDESKMPRKPNERYSDFNHVKSIEWPPDGTTVLADMADHHIRTFILPPDLLEEKQSPHHLTPYSVLPSTEPTYATAIYPFYSLQEPSTTLFLSSVRDHPIRLASALVPTSVATYSLVNPTTEAFITPHSLIYPSALGGTHFLTGSDSLICLFDVSRPGKDGPVTWMPTIPSKRKQAVGGGVGMKGIISAMAVSPTGDGVLAAGTFSRQIGLYDSNGSGQSLGTFSVAKTEANRHIGGRGVTQLLWSPCGRYLYIAERNSDGVLVYDIRATGQLLGWLEGRKALTNQRMKIDIVPTGQGESHEIWAGGTDGYMRVWRDSALTAGPQKPLWEWKVHDDSVNSTILHPLGSIAATAGGQRHHFDDTVAEEGGPFTTDSTLKIWSMPFLEGELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G475</accession>
    <name>A0A2I2G475_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_409908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702988.1">
        <property type="nucleotide sequence ID" value="XM_024846822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G475"/>
    <dbReference type="STRING" id="1392250.A0A2I2G475"/>
    <dbReference type="GeneID" id="36554521"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409908"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="336" mass="36917" checksum="3C438E60629D9DF7" modified="2018-02-28" version="1">MPGTPTTNTTLLHNPELCTLDTCPMELANIEYVPNLAGNIFFVAIFGLVLAFQLGFGIKYKTWSYMIAMIGGLALEIIGYVARIQMHYNPFPSDPFLMYLVCLTIGPAFLSAAIYLCLSRIVIAYGEKIPFFRARTYTILFITCDIIALILQAAGGAIASTADDKDTSDIGINIMVAGVSWQVFSLFLFVGLCTDFALRTRRAAAHQFNPFFEGLRQTKPFQGFLLSLGVATLTIITRSVFRCAELSEGFDGKLANDEITFMVLEGAMIAAAVIALTVYHPGWVWKGQWNDAVWSVRSDKGDKGGYKGVVLEGNDESYRIGSNERMVNTAYDGPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4U3</accession>
    <name>A0A2I2G4U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_199598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703201.1">
        <property type="nucleotide sequence ID" value="XM_024842754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4U3"/>
    <dbReference type="GeneID" id="36550452"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_199598"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="183" mass="20849" checksum="80D7A3EFCAB8AE11" modified="2018-02-28" version="1">MIDAIRHTGDCLLPFHKPVPFAGLEFYCSRVSNHRPMAGRSAGRDHLDALRRTICLSPALPRGIVVGCWGKQRTDKHGQHHRETDKSYIIRRLNPTTEKGRSFLGVVITSFHHHHRPRCYHPQPPLSGTTLTLLCPRRRFLESFTLFIRPHHAYDRAVHGVSDDKEQALDHHMVGTRASCSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4Y9</accession>
    <name>A0A2I2G4Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_437646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703248.1">
        <property type="nucleotide sequence ID" value="XM_024849415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4Y9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4Y9"/>
    <dbReference type="GeneID" id="36557114"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437646"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="246" mass="27001" checksum="FC6ED5ECB2E87622" modified="2018-02-28" version="1">MFIARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATSEGVILGVEKRVTSTLLEASSVEKIVEIDQHIGCAMSGLQADARNLVEHARVECQNHAFHYAEPLRVESCTQAICDLALRFGETGDDEESVMSRPFGVALLIAGFDEDGPQLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHRSLTLTEAETLVLKTLKQVMEEKLDAKNVQLASVTKEKGFRIYNDEEMGSAVARLGENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G513</accession>
    <name>A0A2I2G513_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_201713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703270.1">
        <property type="nucleotide sequence ID" value="XM_024842765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G513"/>
    <dbReference type="GeneID" id="36550463"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_201713"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="122" mass="13313" checksum="6594D373B2CB7D41" modified="2018-02-28" version="1">MASALMLAFRVAGGTALGPSLIGKKHTASTGAGSRIRVDMLCSVDAYAWTCVVSMSSAFSLFLLVVIWLGDAPGRRTVIPNWRVGVYAFMLGFGVSMVSLRIYWPSRCRWFGLHGSIRMFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G554</accession>
    <name>A0A2I2G554_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_510711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703314.1">
        <property type="nucleotide sequence ID" value="XM_024854804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G554"/>
    <dbReference type="STRING" id="1392250.A0A2I2G554"/>
    <dbReference type="GeneID" id="36562510"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510711"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="730"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1132" mass="125800" checksum="BAF1BDDC71200FFD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5C8</accession>
    <name>A0A2I2G5C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_437800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703390.1">
        <property type="nucleotide sequence ID" value="XM_024849449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5C8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5C8"/>
    <dbReference type="GeneID" id="36557148"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437800"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="614"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="671" mass="72940" checksum="52C44C561CA37221" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5K9</accession>
    <name>A0A2I2G5K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_510850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703470.1">
        <property type="nucleotide sequence ID" value="XM_024854820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5K9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5K9"/>
    <dbReference type="GeneID" id="36562526"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510850"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="189" mass="21006" checksum="3DFFB0905EE9F0DE" modified="2018-02-28" version="1">MRKNLESAKNPTNPVDLFDCIVTQSLTLDINRGFCITTGYTMNPAHKKLIIFLHILGEIVKPAFGNDEDALGDITAEELGKVMRSLGQNPTQSQLQDMISELDADHTNSIDFEEFLTLMTATTKEFNPETELRQAFDVFDKDSSGTINSTELCQVMEAIGEKLTDGEIQEMMRIQTGTGQLAVRPPAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5M3</accession>
    <name>A0A2I2G5M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reductase with broad range of substrate specificity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_359751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703445.1">
        <property type="nucleotide sequence ID" value="XM_024844373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5M3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5M3"/>
    <dbReference type="GeneID" id="36552073"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359751"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="293" mass="31132" checksum="FED99DB35DC2784C" modified="2018-02-28" version="1">MAASPIQNGHFVHDNTTAPEHPGLLSLFSLKGKTAIITGAGAGIGLAVAQGLAEAGANVALWYNTNDKCHERAAEIAAKYGVQAKAYKVNTTDPAAVEAAINAGAKELNGRLDILIANAGVPWTKGPMVDGPLDHYSQVVDINLNSTFYCAKYAAAHWRRQKEEGTDLNGQPLTNFTYGSFVATASMSGHIVNFPQLQSAYNAAKSGVIHLCKSLAVEWVRFARANSVSPGYIVTEISNFVPQETKNIWKDKIPMGREGQVGELKGAYLYLASDASSYTTGADLVVDGGYTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G663</accession>
    <name>A0A2I2G663_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_411170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703669.1">
        <property type="nucleotide sequence ID" value="XM_024846877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G663"/>
    <dbReference type="STRING" id="1392250.A0A2I2G663"/>
    <dbReference type="GeneID" id="36554576"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411170"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF4">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="51"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="395" mass="42344" checksum="531869FE7170E7EE" modified="2018-02-28" version="1">MAPGELIHPVNETDRLLLNDTTGHSLKSRSKLIHPPFANPSLQVTADHNLKQVDAPVFAPQEGEVLLQIKATGICGSDVHFWKTGRIGSLVFEGDCIIGHEAAGIVLKCGPGVKGLSPGDRVAVEPGVPCANCFLCNEGRYNLCEDVQFSGVYPYHGTMQRYKVHPAKWLHKLPDNVSYAEGALLEPLSVVMHGIRSAGLTLGRGVVVCGAGPIGLIALAAARASGAHPIVVTDLEPRRLAFAKEFLPSCHTYQVDPSLDAQGNAAGIRRFFGDDEYVAPETVLECTGVESSVCTAAYTARRGGTVMVIGVGKAMMNNLPFMHLSLAEIDLRFINRYRDTWAPGIACLSGGILDLKKLVSHVFPLEKADEAVRFSSDTKNGSIKVLVVDEVEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6R5</accession>
    <name>A0A2I2G6R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_411488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703865.1">
        <property type="nucleotide sequence ID" value="XM_024846892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6R5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6R5"/>
    <dbReference type="GeneID" id="36554591"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_411488"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000005">
        <property type="entry name" value="Quinic acid utilization activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="894" mass="98684" checksum="7B4DACFCDA2BF83F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G737</accession>
    <name>A0A2I2G737_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_314628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703996.1">
        <property type="nucleotide sequence ID" value="XM_024843274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G737"/>
    <dbReference type="GeneID" id="36550974"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_314628"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="219" mass="24877" checksum="18CA692C56DE4CB0" modified="2018-02-28" version="1" fragment="single">MPPTLYVIRHAQGEHNVNDSHHLRDALLTETGKAQCKELQEKFPHLEDIEVILASPLRRTIQTAAFTFTPELGKRQVPVILVPKAQEISGLRCDIGHEASVMKSEAPKLIADAAPAWDATNLDITFVDESWNSKQGIYAPNLTAVRQRAADMRNWIYNRPEKHIALVNHRGFLHYLTEDWTGYVRGKGTGYLNCEYRKLEFTEDSNDKESHIRECGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G781</accession>
    <name>A0A2I2G781_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_436477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704036.1">
        <property type="nucleotide sequence ID" value="XM_024849164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G781"/>
    <dbReference type="STRING" id="1392250.A0A2I2G781"/>
    <dbReference type="GeneID" id="36556863"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436477"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="188"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="309" mass="34735" checksum="EC563C8E09D73B19" modified="2018-02-28" version="1">MGAAVVDTSRWHLVINGLVERPFSLNLEQLRQMPAESVTSFHECYGSPLVPPTKNVWRIGNVKWTGVPLRYLLSIARPHPGRGLFVWSDGLDSGTFGGVSADRYQKDLPMEKALAPEVLVAYAMNGQPLSKKRGGPVRLVVPGWFGTNSTKWLSRLSVRETRAGGAFTTVFYNELDPVDVEGVRKRPVWKVQPNSIIVRPKPQEVFDCPGYVEGWGRAWGADEIVRVEIRLDQEDTWCEASVTRRKQFEWQLFSFRVFVPQAGDCYIQARATDRRGLRQALVGSRNHVPTVPIRVESGRSTENTGDDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G787</accession>
    <name>A0A2I2G787_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_446582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704051.1">
        <property type="nucleotide sequence ID" value="XM_024850812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G787"/>
    <dbReference type="STRING" id="1392250.A0A2I2G787"/>
    <dbReference type="GeneID" id="36558511"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446582"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="479" mass="52118" checksum="BF0FD812271602AA" modified="2018-02-28" version="1">MIAPSARNLPPIIWAVAIFGSLSSAGFGFDQAWWASIMSSQQFARRFGSQDPTEETWGLTERQQSLGTGLGYAGIQSAVVSIGVIIESTCQTSYAQFLVGKVVVYFGGGIASNVIPVYQGECAPQSLRGLMAGSYNVFLMVGGLAAALVVYLCRHIPGDWAWRGVVVAQIAIPALNWLSLPFLPESPYWLMHRGKLDEAAASLARLRALSLSAARTELDHLHDLALQAQQEQQQHKSSSSSWSACLTDPILRRRTIICVGAQIFQQAQGISFVANYQAVFLQRIGFRQVLLMSVVVYVIGIAGNLAGVIVADRLGRRRVLLISAALLAACMLSIGGLTNDGTPREYRTQVAAVALLMLWFFTFQATWGPLAWVLTAEIPPASWVRETMVALAGLAAYGTGLVIVFVNPYTQAEIEGSVAFIYGGLSVAATGFVWFVVPEMKRRSLEEIDEMFAEKVPSREFRGYCCKAGTLQDERIEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7S5</accession>
    <name>A0A2I2G7S5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_446698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704205.1">
        <property type="nucleotide sequence ID" value="XM_024850823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7S5"/>
    <dbReference type="GeneID" id="36558522"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446698"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="27"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="591" mass="64698" checksum="B58205505AF09D76" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G826</accession>
    <name>A0A2I2G826_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_358218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704338.1">
        <property type="nucleotide sequence ID" value="XM_024844271.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G826"/>
    <dbReference type="GeneID" id="36551971"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358218"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000266">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000768">
        <property type="entry name" value="Pentatricopeptide repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="7">
        <location>
            <begin position="486"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="979"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1281" mass="140208" checksum="C09209E395423D1D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8G6</accession>
    <name>A0A2I2G8G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_357004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704473.1">
        <property type="nucleotide sequence ID" value="XM_024844191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8G6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8G6"/>
    <dbReference type="GeneID" id="36551891"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357004"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="230" mass="26958" checksum="950C489DEF4ACDA1" modified="2018-02-28" version="1">MPIPCEVKLSDITFLEKLKESKYSAIFKVSIHGLLRVMKVYHNLDLCPPEWAPPDREVDLFVCESTAYQRLHDKGLCKRGLILDFYGTITNIQPLLCQPSLGMFLEDKRPPNAVLIEYIPNMRMIDLSNFSERRVSELRRILLEDIHPAGVLHGDPMPRNMMVQDKDGRVLWIDFDSAQTFTEDGFLTPRQEWWVKEEVEMVDYFVDALARDCEDGKIDRTRSYYYEWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8W1</accession>
    <name>A0A2I2G8W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_509892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704624.1">
        <property type="nucleotide sequence ID" value="XM_024854718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8W1"/>
    <dbReference type="GeneID" id="36562424"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509892"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="110" mass="12256" checksum="3426211628D7847F" modified="2018-02-28" version="1">MSFHTTSQGLKLGHEDGFTVLSADLRDKHGHYNHRKIRLDDHIGNTDGWFIWGGSNFTRSASNVTLEHTEWGPKLCADLRTHNGGSKGRQGLMLADKIANDDGHFKFLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Q9</accession>
    <name>A0A2I2G9Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P170DRAFT_456218</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704922.1">
        <property type="nucleotide sequence ID" value="XM_024851601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Q9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Q9"/>
    <dbReference type="GeneID" id="36559300"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456218"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000022">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="37"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="287"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="501"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="600"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="705"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="783"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1157"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB49620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1257" mass="142056" checksum="EE8683883A452499" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9T9</accession>
    <name>A0A2I2G9T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_384829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704952.1">
        <property type="nucleotide sequence ID" value="XM_024845691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9T9"/>
    <dbReference type="GeneID" id="36553390"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_384829"/>
    <dbReference type="OrthoDB" id="5420895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF2">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="11"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="375" mass="42999" checksum="E52F48FF73038405" modified="2018-02-28" version="1" fragment="single">MSSRDGDFWGLLINPDKSPAPLLEQLCLGIAQIMTSFDDYATSDLTPERLATFYGKVGGNYDVLFLDTKSSALSFIYQRLGCFHSIQPSTDPYKPPSVPALQPNGFVRWQTIQLLLDPDEHSRYLQNAVELWDIENPNGGYFPKDIPRDAFPAESDPEMVNWHEEVSRRFEFDYWKKNIFRSSPPSFGTYHSHFSQKEASGKEDYPNQRQPTSHRRHATTTNIPPIHPQRRRSAEIPSGGRRVHSTFVRRPEEFQEYKSPRAPSPPTWPKGRTRGRERASFSRPVSPGTVGHETSDASSEDSAWGAKDPRRYQENLSPPQTSHARRHSHEAYARRPRRELSPDAHRRHGPRETYQSPDSGRLYDSDGARRVRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAC5</accession>
    <name>A0A2I2GAC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_409438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705128.1">
        <property type="nucleotide sequence ID" value="XM_024846783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAC5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAC5"/>
    <dbReference type="GeneID" id="36554482"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409438"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="529"/>
            <end position="530"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB49826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="604" mass="66716" checksum="C9092991D17F33A7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBB0</accession>
    <name>A0A2I2GBB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase CipA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_454743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705439.1">
        <property type="nucleotide sequence ID" value="XM_024851472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBB0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBB0"/>
    <dbReference type="GeneID" id="36559171"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454743"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="310" mass="33542" checksum="3AEE99BAF756C134" modified="2018-02-28" version="1">MSVIRNVAIAGASGDLGKVILRALTESNLFEITVLTRHESSAQFAASVRVIRVDFTSVTDLTAALANQDAVVSVLNSDALDTQLPLIDASLAAGVKRFIPSEFSANNGNPKTATLPAYKVKIAVHEIIQRHARENPQFTYTVIRNGPFLDWSLALGFFLTLKPAPGGSGAITTPFYDGGDRPFSTSTLATVGKAVVGVLHRLEKTTNRVVFVHDLVTTQRKMLAIARKIAPEREWNTVHVSTADMEARARENYAQGKVDIPALMGCFCRSVFAEGYGGEFEEVDNQLLGIPGKNDEDLEGLIRDALEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBT5</accession>
    <name>A0A2I2GBT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tryptophan dimethylallyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_508536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705638.1">
        <property type="nucleotide sequence ID" value="XM_024854586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBT5"/>
    <dbReference type="GeneID" id="36562292"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508536"/>
    <dbReference type="OrthoDB" id="5392033at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="408" mass="46463" checksum="DE9EE3835179626B" modified="2018-02-28" version="1">MVRANALQFELLDQSTRCADESQREWWQKTGPLLASLMSWAGYTSQSQRQCLIFYHACIVPYLGPYPQTFPSAMTHNELPLELSINFQQRGGASPVIRVAVEPLTSVSGTSQDPYNLSPIRDFLSRLEQLDLEGYDSRVFEHFYPQHTLSERECRDLQARNEAIRELSQVSFGFDLKPDGIAAKGYTFPALKCHAAGTDLCSVVLGSVRAYLGAADRYNTLGLMQEYIETTDARDNFGFVFSHDCAPPEQSRFKLYGRTKDISWDRVREIWTLGGRIDSSEASTGLEYLHQLWTLLRMDEPHPLGLHLVWNYETKAGLTAPATKIYFPLYGLNDQSNVRAVAQYLTHIGLEEYGNAYEQAVRDTFPGLDIRQTDRLICWVSFAYTESRGVYLSVYYHSSLEYPWLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC26</accession>
    <name>A0A2I2GC26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_473988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705734.1">
        <property type="nucleotide sequence ID" value="XM_024853095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC26"/>
    <dbReference type="GeneID" id="36560793"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473988"/>
    <dbReference type="OrthoDB" id="4497333at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014140668" evidence="1">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="102" mass="10838" checksum="99FFDDFBD1C569BF" modified="2018-02-28" version="1">MRFSGQSLSMLCLLVTGTLAAFPGINDENYGIGKPHGIDKGNSICLGQCTPNPALLTCAKPVFKKDRGCFVCCFSDDDLDGFDKQIPEDPVGDGVLPLPFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC29</accession>
    <name>A0A2I2GC29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_143680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705733.1">
        <property type="nucleotide sequence ID" value="XM_024842485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC29"/>
    <dbReference type="GeneID" id="36550182"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_143680"/>
    <dbReference type="OrthoDB" id="3599883at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35087" checksum="49BD94C39E116FAC" modified="2018-02-28" version="1">MTQGHYHPHHRRTLSGSNVPKVRSARPALHRKGTSFVNHSIAKLGSGNPRRCESDDDRQPEMAASFLNFCAMCERQITVPDNSLLYCSESCRRKDSHKPLSASFSSNSSMPSSSTPPTSPPMSPRIIVAPMTPTKAPMSTPAIRIPGEFNDSKTDQDPSEWKPVIPMSASGAEPLASSDAWHYLSQFHGGEAPLMRRPKANRNSSSSLSTLMSSSGPIPSLAHTPSTVASSVSSNASDYLSYVPESAFRPLPPRHNPSFSSSACATKGVELVVPHVEIQADDAPVDDTSGSIFPANSSLWDDVPSEKAPLATAAIAITANGVSTGPRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC36</accession>
    <name>A0A2I2GC36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_435596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705709.1">
        <property type="nucleotide sequence ID" value="XM_024848973.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GC36"/>
    <dbReference type="GeneID" id="36556672"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435596"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001090">
        <property type="entry name" value="Vacuolar membrane-associated protein iml1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="8">
        <location>
            <begin position="1335"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="679"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="720"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="833"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1421"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1792"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1801"/>
            <end position="1811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1837" mass="206116" checksum="CEFE3561DE87C28A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC96</accession>
    <name>A0A2I2GC96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_146077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705802.1">
        <property type="nucleotide sequence ID" value="XM_024842498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC96"/>
    <dbReference type="GeneID" id="36550195"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_146077"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="95" mass="11589" checksum="43A4E2B957973487" modified="2018-02-28" version="1">MFQAQYILRKALLTNYKCMKINQLTNQLVGDGPLFCYDFLLLFLSFFLSCFFFFNARRRPNADTFPMWCRVTRQYSCQDMHARVEMLQEDKLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCP7</accession>
    <name>A0A2I2GCP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_381594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705955.1">
        <property type="nucleotide sequence ID" value="XM_024845578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCP7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCP7"/>
    <dbReference type="GeneID" id="36553277"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381594"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="702" mass="76414" checksum="689A64B8844D18DB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCV1</accession>
    <name>A0A2I2GCV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_152020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706003.1">
        <property type="nucleotide sequence ID" value="XM_024842526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCV1"/>
    <dbReference type="GeneID" id="36550223"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_152020"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="222" mass="26032" checksum="8C86B957D69269D4" modified="2018-02-28" version="1">MDPPDGRIDVAAGLVPFVPFVLLLVRRWRPWSSICERPCLCPPLSLFLVRFWPRRRGWWSSWVFPVWTLTRRNEKTNNKINRKERGGRGWRRPERLPEDTKTGVESIFLWITSAGSTRQGEENACRVLHLATGMCQFTYHFSTEEGVELRDDLPLYPPCVRFLIRQAEVRGRLKIKIKMKQEIKKVTQVTISLVVVQNEHVTLSPRFDPKKGKIMYYIPVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCV3</accession>
    <name>A0A2I2GCV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705997.1">
        <property type="nucleotide sequence ID" value="XM_024847598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCV3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCV3"/>
    <dbReference type="GeneID" id="36555297"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425010"/>
    <dbReference type="OrthoDB" id="5422320at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="168" mass="18857" checksum="897EA416BB8BCD34" modified="2018-02-28" version="1">MSGLQIPSVTLEDLEAFQAKHFPGSAQTPAIQGPYDETVDHQLEEYEDEDDLGYYPDGVKRTLTDEQIRIFRHSEIHSLLREKQLREEALLEAAEEERREEAAETQKPAASDADTAVPTNKHERTDGQEASDSLLDYGEDAPVGKAQKRARPGYAPPFVGRKIISYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDR2</accession>
    <name>A0A2I2GDR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_354050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706305.1">
        <property type="nucleotide sequence ID" value="XM_024844007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDR2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDR2"/>
    <dbReference type="GeneID" id="36551707"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354050"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014135167" evidence="6">
        <location>
            <begin position="18"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="595"/>
            <end position="596"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="639" mass="70546" checksum="7C14F8E95146AB95" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDU2</accession>
    <name>A0A2I2GDU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_406477</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706303.1">
        <property type="nucleotide sequence ID" value="XM_024846629.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GDU2"/>
    <dbReference type="GeneID" id="36554328"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406477"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000377">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000119">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="739"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1177"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1564"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="736"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="902"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1217"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1519"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1702"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1263"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1316"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1343"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1368"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1421"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1449"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1487"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1702"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1724"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1782"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1842"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1860"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1891"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1969"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1995"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2014"/>
            <end position="2027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB51001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2053" mass="223841" checksum="B433AC6A516A3DCD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEC2</accession>
    <name>A0A2I2GEC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_355320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706536.1">
        <property type="nucleotide sequence ID" value="XM_024844085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEC2"/>
    <dbReference type="GeneID" id="36551785"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355320"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF8">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="182"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="402" mass="43193" checksum="7889D7E8AB82A109" modified="2018-02-28" version="1">MECNRVMDEYIASLGQRLRNLNKSIHDNPELAYEEHHAHETVCTFLEEHTTIPVTRRSYGLATAFEAISGSSGRCVNFNAEYDALPGIGHACGHNLIATAGVAAFLALSHLIERFGISGRAHLLGTPAEEDGGGKIDLLKAGAYDKADVSLMIHPMSDGSLHELGIAGVAGQTSISCFDLICTYEGVSAHASANPWDGVNALDAIVCAYNNISMLRQQIKPEERIHGAIMEAPKITNAIPERTVTKYTVRSPSMKNTVALGERVRACLQAGALATGCKLHIEETEIYADLRVNEPLCGEFAKCMKEQGEQVQDVASSPIPGSTDQGNVSYALPALHANIGIPVSSGAQPHTHDFCTAAGRLEAHEIILKAAKAMAMTGWALLTDNSLYGEVRDAFDRDCQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEV1</accession>
    <name>A0A2I2GEV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_471343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706711.1">
        <property type="nucleotide sequence ID" value="XM_024852830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEV1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEV1"/>
    <dbReference type="GeneID" id="36560528"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471343"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB51409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="366" mass="41843" checksum="9611E51818C59C79" modified="2018-02-28" version="1">MGFVYSLIWQSPRQRLLQSLRGRTFTIPDLPSAFAHWPQGVHPEMPRLAGEVDRTIIRFYHEPRIFRKMKEADAASFGAMWWPYASFDRLCIATYLSMWLFAWDDETDSTEISHLVHQTDKAARFREQTREFIHACLSCDKEGPSELPVDGLNNPFIASFQVVGEAITRSCNEDQVNRFRLELDKYIDMAGLEQNIQMTNHLPTVDEYWNRRKGSSAVGVCLAITEYCYAMEIPPNIMGGADMRRLWDLINIIVSSTNDILSLKKEIAQGQTDSLVPILYLQYGSLQTAVDEAADMIFSSAKEFDQLAEKLLSSQPEDDAQDNLRKFIDGCRYCCSANLNWSLRSKRFKLNAQSLQSGFEVTLSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEY3</accession>
    <name>A0A2I2GEY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_506470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706742.1">
        <property type="nucleotide sequence ID" value="XM_024854394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEY3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEY3"/>
    <dbReference type="GeneID" id="36562100"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506470"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="93"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="359" mass="38667" checksum="C6E421407D0D3BA6" modified="2018-02-28" version="1">MADFSLYTGPSEEWLALKATLPAPPDFVSLDVLKAEANAGREAIAAKALVTEGLQSQVAFQDYSIPARDGVTLQARTYRPASLPPTQPLPVYIHFHGGGYFLGTLASEDAICSRIVVGLTAESTPVVVVNVNYRHTPEHKYPIAWNDAEDAFHWVHDHLTEIGGDADQVIVGGISAGAHLTASLVLAQHLGTDEALLKRPKVKGQVLMIPSLVSRGCYAGQLAKLKDPRVSSYVQNEHAPILPASRVDFFIGLLEPFGVDKDLRLNPGNATPDQVKGMPPTTFGVAGRDPLRDEGLLYAMLLAENGVPTDVNVFTGLPHGFRRHGALSESKRWDAVMNQGIKWALGDPVATGAFDIKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGX6</accession>
    <name>A0A2I2GGX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_377656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707437.1">
        <property type="nucleotide sequence ID" value="XM_024845411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGX6"/>
    <dbReference type="GeneID" id="36553111"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_377656"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="343" mass="39411" checksum="183DE5A1CBC4EB02" modified="2018-02-28" version="1">MLFFGGGVQSPRRRSREKAIFITIFIVFALYFLFFANTSGRKQAAAVHEGVVSQGGPNRDTRSGQATPLRQPQNVEKDLVVASMKKDDVSWLFEFFPEWHKSIYVVNDPDAELTVKLNKGRESMVYLTYIIDNYDNLPESILFIHSLRYQWHNDDPYYDGVPMLRNFQVPYLQKQGYVNLRCAWVLGCPVEIHPLTDTHRENVHAGEYFKNGFMELFPGAKVPDEVGVSCCAQFGVTKWKILERPKSDYERFRKWLSETTLPDDLSGRIMEYSWHMIFGKEPVYCPSAEECYCKVFGLCDLTCTEGDCAGRYALPPFSSLPRGWPYIGWKGQKQDPSKGLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH99</accession>
    <name>A0A2I2GH99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Indole-diterpene biosynthesis protein PaxU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_453695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707547.1">
        <property type="nucleotide sequence ID" value="XM_024851381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH99"/>
    <dbReference type="GeneID" id="36559080"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453695"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31911" checksum="2E52D19E6651B25B" modified="2018-02-28" version="1">MAQSFLHFQSLGVRTWLRCPEKPHPGQLVVICTWLGASSKHICKYVDLHRAVAPHARILLIESEVAILVSSYAHQRRRIQPAVRAIYDTLAEGSHAHPPKILLHTFSNGGTNTATQLLITLRETLHQPLPLVGLVLDSSPAKGTYWKSYDAMVFSLPPAGRFFGSMVVHFLLVLLYTWIACGNENPASLMRRTLLDEETVDPGDEMRDVGVNGNICYLYSEADKMTDWRDIRDHAEDARLKGWNVQEIRFDGSGHCAHMAQDEAKYSAAVQRAWDWSLPKASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI53</accession>
    <name>A0A2I2GI53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_402816</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707853.1">
        <property type="nucleotide sequence ID" value="XM_024846447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI53"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI53"/>
    <dbReference type="GeneID" id="36554146"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402816"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB52551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="512" mass="56354" checksum="C542B3F8400E1D30" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJZ8</accession>
    <name>A0A2I2GJZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaps-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708506.1">
        <property type="nucleotide sequence ID" value="XM_024848830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJZ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJZ8"/>
    <dbReference type="GeneID" id="36556529"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434914"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="670" mass="75971" checksum="CF53964998F8A397" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKR9</accession>
    <name>A0A2I2GKR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnogalacturonan acetylesterase RgaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_352710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708785.1">
        <property type="nucleotide sequence ID" value="XM_024843934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKR9"/>
    <dbReference type="GeneID" id="36551634"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352710"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014169807" evidence="3">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="248" mass="26353" checksum="9EB92B647F87151B" modified="2018-02-28" version="1">MRSFILPLSLLPGALAATVYLAGDSTMASTNGGTTDGWGDYITEYVSGTVSNKAIGGRSARSYTREGRFDDIASVVQSGDYVVIEFGHNDGGSLGNDNGRTDCPGTGDETCETTYDGQQETVLTFPAYIQNAAKTFTAKGATVLISSQTPNNVWETGEYAYTPSRFVEYAQLAAENAGVEYVDHGAYVASRYESLGGDTVNRYYPSDHTHTSPDGAAVVAEAFLKAVVCSDVALKEVLSTEDFEGECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKZ0</accession>
    <name>A0A2I2GKZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_435148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708843.1">
        <property type="nucleotide sequence ID" value="XM_024848870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKZ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKZ0"/>
    <dbReference type="GeneID" id="36556569"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435148"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="527"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="6">
        <location>
            <begin position="663"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="97742" checksum="06A9C72AD803681C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL09</accession>
    <name>A0A2I2GL09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_473429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708872.1">
        <property type="nucleotide sequence ID" value="XM_024853037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL09"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL09"/>
    <dbReference type="GeneID" id="36560735"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473429"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="810" mass="89252" checksum="028ED3537CE79050" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL92</accession>
    <name>A0A2I2GL92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_460024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708929.1">
        <property type="nucleotide sequence ID" value="XM_024851904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL92"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL92"/>
    <dbReference type="GeneID" id="36559602"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460024"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF188">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="505" mass="58632" checksum="ACEE2611AD023445" modified="2018-02-28" version="1">MYLIFILPSLCLLYHLLRLFHTAFTLRSLSSVPGPWVTRLTKLWYFDRVRRGHFEEDNVRLHRQYGPVVRIAPDHYSISDRAAVKTVYGTGSKFAKSAWYEGWKHPDPDRWTLFPDRDVKRHAETRKRFSSLYSMTSLVHYEQFVDHCADIFTQRLTEFTERGEGFNLGHWFQCYAFDVIGEITFGQRFGFLDQGHDIEGTMDALQKLMAYSTLVGIYPQWHPRLFGPLSRFSWSGAGGRAYIMRYVGERIQQHNAQPKRDPESETLQTQDFLEKMTIARDKDPEKVTDYHLFMMGQSNVIAGSDTTAISLSAIMYFLLRSPAVLEKLRREIDGFTAQGRCSPRVTFKESQEMPYFQAVIKEALRMHSATGLPLWREVPAGGAEISGYFFPEGSVVGVNTWVAHYDEEIFPDAKSFQPERWIEAETDPERLKIMNDMYMPFGLGSRTCLGKHISILEMSKLIPRIVRDFEFGIKHQKWNTENFWFVKPIDFEVTVTKRAPVQTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLN7</accession>
    <name>A0A2I2GLN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_396485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709102.1">
        <property type="nucleotide sequence ID" value="XM_024846120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLN7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLN7"/>
    <dbReference type="GeneID" id="36553819"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396485"/>
    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="742" mass="84057" checksum="BEE773548C4CE843" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM88</accession>
    <name>A0A2I2GM88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_442161</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709271.1">
        <property type="nucleotide sequence ID" value="XM_024850440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM88"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM88"/>
    <dbReference type="GeneID" id="36558139"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442161"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB53969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="47092" checksum="DCE7572741D3DCBB" modified="2018-02-28" version="1">MTRVLLYTKRTHNTCTVIPLGHGRDDVPNILTAVEECGRIPGGRILLPEPYTYRINQRLTTHLEHSTLSIHGTLLFSDDITYWVNNSYRVDFQNQSSAWRITGHDYEVNGGPSMGGIDGNGQLWYTWAKGGSNVFGRPIPMHIYNSTRVVVRNIAIRQPQFWAVLVDESSHVLLENFYVNATNSDFYAEEDAVWIQNTDGVDTFRSDHVTVKDWVYEGGDDAVAFKGNSTNVVVQNMTVYGGPGIAFGSLGQYPDRVDIVENITVRDVVLQPSFQRAINSGIYFKSWIGVNFGNPPNGGGDGHGYLRNVTVENIQFKDVQMPIYFDTCLSYLYDQNVTQYCDTSTYRFDDIHFKNITGNGLATPTDYPGENITFAVSVICSEKAKCGDITFQDVDISLPDEYEGKSVICKNAEVDGLECNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMI4</accession>
    <name>A0A2I2GMI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_460319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709376.1">
        <property type="nucleotide sequence ID" value="XM_024851930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMI4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMI4"/>
    <dbReference type="GeneID" id="36559628"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460319"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="248" mass="28368" checksum="4016510082EFDE1B" modified="2018-02-28" version="1">MSLLVKHITKADIPRVMNIMFSVMAPTGFGRTTGEVPNRDITFEDFISSPYSVNMARRIAEELNTDPTLHYLQAVDSRSGNMVALGKWHIYRGDQGLQAWRSSIRTDKSMQIPFGLNGAGYRCIMGKLFDKRKFFFGEGGREHCLFELLLTHPRHERQGAGSLITQWGCDQADQLGLDCYLESSDPGYPVYQRKGFKDMSKDPNQNVIEYTVDEFTGRQGFEEDKMRFTCMIRKPRGRGVPNRKKMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMP0</accession>
    <name>A0A2I2GMP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_319011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709445.1">
        <property type="nucleotide sequence ID" value="XM_024843300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMP0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMP0"/>
    <dbReference type="GeneID" id="36551000"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_319011"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35270" checksum="2EE2D8101B0D205D" modified="2018-02-28" version="1" fragment="single">TDTMTANLHIIDPDGEVTIVLHHPNAPFAAFDKEVGNDNNGDIDSPDGDTSDSRQEHDEVRFQVSAKHMILASPVFKRLLKGPWKEGTELAKQGSVEVVVDSWDSEALLILLNILHCRHRDLPHEMSVEQLAKIAVITDYYDCHASVEIFTDMWVKSFRPASSDTPFNEMIMRLFIAWVFRRREAWDQVHIDVMKWSQRSIHSFGLPFPDRLIGNAPSPRPNPVTYGLNKGREDAMNTIIDSLHGSVTKLITSTNEGENGFDKRCFDCGSSMLGALMKQMHSASLLWPRPMPPFDGLSFDGLVKTLLVFENPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMR2</accession>
    <name>A0A2I2GMR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_397261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709465.1">
        <property type="nucleotide sequence ID" value="XM_024846163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMR2"/>
    <dbReference type="GeneID" id="36553862"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397261"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="705" mass="79017" checksum="403E17B62B800B4C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN92</accession>
    <name>A0A2I2GN92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General amino acid permease AGP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_397684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709646.1">
        <property type="nucleotide sequence ID" value="XM_024846191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN92"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN92"/>
    <dbReference type="GeneID" id="36553890"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397684"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="66"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="572" mass="62722" checksum="6BB3D87501920680" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNR0</accession>
    <name>A0A2I2GNR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_373683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709805.1">
        <property type="nucleotide sequence ID" value="XM_024845252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNR0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNR0"/>
    <dbReference type="GeneID" id="36552952"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_373683"/>
    <dbReference type="OrthoDB" id="4835445at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="512"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="715" mass="79507" checksum="48D5BBC3B658C046" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPQ3</accession>
    <name>A0A2I2GPQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_26233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710151.1">
        <property type="nucleotide sequence ID" value="XM_024843085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPQ3"/>
    <dbReference type="GeneID" id="36550784"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_26233"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="83" mass="9517" checksum="EEEA8DD61841CE9A" modified="2018-02-28" version="1">MIDLRRPNRPVWSALLPIPNQPMHRRWYSILDPNGQNNWHMQVTSPLHEARLTGTNPQRRALDGGIHEIGHLPTTCSLATSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPW4</accession>
    <name>A0A2I2GPW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_470348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710215.1">
        <property type="nucleotide sequence ID" value="XM_024852744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPW4"/>
    <dbReference type="GeneID" id="36560442"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470348"/>
    <dbReference type="OrthoDB" id="5422293at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="252" mass="30154" checksum="AC59EC4FD407CF9F" modified="2018-02-28" version="1">MPPRRRPNLSLWTRFRLWLRYAHSPLRLRASYIRLSHQHKYPLFALLRLFIPYPSWYFPIPGPFPLRSLVEDKKNQTGIILSRFGDIHNLRDIPIWRMRDTPLRSIYRLYELHLADRYVLMGWETEYFFFRRDWKLKDIPDPNDPDPLRYAIIASIVEELHEAVNWRLSLGLRRNKEHVYREEDGDPWPPFTPEELPLWTEKVPPIDKDLLSVSVPPESLDSEGNLVLEENGKAPNFAKRNIITNTGWLYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ13</accession>
    <name>A0A2I2GQ13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_460934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710266.1">
        <property type="nucleotide sequence ID" value="XM_024851988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ13"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ13"/>
    <dbReference type="GeneID" id="36559686"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460934"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="57"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="429" mass="47084" checksum="51C6DB2B31716A1B" modified="2018-02-28" version="1">MLSTLRVAGRKAASRDASMRTVVVGARNASAWSNVPQGPPDAILGITEAFKADSFKEKINLGVGAYRDDKGKPYVLPSVRAAEDKVVASRLDKEYAGITGIPTFTSAAAELAYGKDSEVLKDNRLVITQTISGTGALRIGGAFLKRFYPHAKKVYLPTPSWANHNAVFKDAGLEVEKYRYYNKDTIGLDFEGLLADIKAAPENSIILLHACAHNPTGVDPTQDQWRQISDVMKQKGHFAFFDMAYQGFASGNADQDAFAPRHFVKEGHNIALCQSFAKNMGLYGERVGAFSLVCENAEEKKRVESQIKILIRPFYSNPPIHGARVASTIMNDAELNKQWLGEVKGMADRIIEMRALLRKNLEQLGSKHDWSHITSQIGMFAFTGLKPEQMEALAKEHSVYATKDGRISVAGITSGNVQRLAESIFKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ42</accession>
    <name>A0A2I2GQ42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_452530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710291.1">
        <property type="nucleotide sequence ID" value="XM_024851282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ42"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ42"/>
    <dbReference type="GeneID" id="36558981"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_452530"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000077">
        <property type="entry name" value="Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB54989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="330" mass="38450" checksum="BC5D27FB5BC6BE68" modified="2018-02-28" version="1">MAPAAQMTYQKDEKVLCFHHEILYEAKILDVKHTVPDDRKSPYEYLVHYKGWKNTWDDWVPQDRLRKFTEENRELATTLRRDAEAAYRQKNTKPSVKRRRGSDPSSVRGSEERQMSVPGRNNKRARDNDIEKEDNFYVRPSVRIVIPDNLKSLLVDDWENITKNQQVVALPAKCSVNQIFEEYEAEEKPKRTTGADTDVLEEVISGIKEYFDKALDKILLYKSEREQYRSIRKEWEKGSGDLADKSPLDVYGAEHLTRLFATMPELIAQTNMDLQSTNRLREELSKFTLWLSKNSSKYFATRYLNMSNEYVEKARGVPNPNPGTATSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ46</accession>
    <name>A0A2I2GQ46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide riboside kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_505640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710308.1">
        <property type="nucleotide sequence ID" value="XM_024854307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ46"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ46"/>
    <dbReference type="GeneID" id="36562013"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505640"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36424" checksum="4EFBF1559DD153B7" modified="2018-02-28" version="1">MATIIGISGPSSSGKTTLTRLLHRIFNSTSPTTSANSNASDNANSNPLKTFIIHEDDFYFPDDRIPTTTLPSGKTIQDWDCAAAIDIHLLSASLTYVRTNGTLPPRLLSKEDQNEVSDSGVSEDVVLGLRRSVQERIAARRGGQRTVAFLEGFLLYAPTGIAEAEAEGEGEGHPLRDVHGLIDVRLFLPAPYDQVKRRRESRSGYVTIGPAPTPTATTKESAGEEERGEVDLEGEDDRPPQNFWTDPPGYVDDIVWPRYVQDHAWLLLPEGESGQGDATSCLGVDPQEVVKLVGQGVNVRTDAGVTVAPGQGDIPMVDILQWAVEEVMKYLETSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR12</accession>
    <name>A0A2I2GR12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_432857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710621.1">
        <property type="nucleotide sequence ID" value="XM_024848351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR12"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR12"/>
    <dbReference type="GeneID" id="36556050"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432857"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="402" mass="44907" checksum="9A9E2EE82C55978B" modified="2018-02-28" version="1">MFHSSKPYSAVTVQIEVLTSEQYEVEDSSGIVDLIEAVTIQGSGPTEASRALRKKLKYGNLHRQLRALTILDFLIQNAGDRFLREFADEPLLERLRIAATDSVSDPLVKQKCKQLFGQWAASYKNTPGMGGITALYRQLPKRKQPANQAKAKVLRDANPSDEPPLGHTVSISAGDGPSTVLSGPKHKHSSSKSLKKEKKDKKEKRIRAPFNLEKEKPEILQTLASSSVASTNLLNSLKLVNRETHRVSEDAEVLNRFETCKQLRRQILRYIQNVESEEFLGSLIHANEELVTALMAFEVLDKSVDYDSDSDQDVLETGWTPDRDDVNESFAGLVINLPKPPRPARPLSISVPSSSSQQARRANDSDSDSETDEDDDEDNPFGDRNEIRTPGVEKFQPTWKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR58</accession>
    <name>A0A2I2GR58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_432912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710672.1">
        <property type="nucleotide sequence ID" value="XM_024848368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR58"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR58"/>
    <dbReference type="GeneID" id="36556067"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432912"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="27269" checksum="DF5640C96B56FEEB" modified="2018-02-28" version="1">MAVLSMADNPPPEVHHYNHLGEVPWDIQNYWAQRYRIFSRYDEGVWLTDDAWFGVTPEPVANKIAEHVANSAPAGRSILVDTFAGAGGNSIAFALSGKWKRVYAIEKNPAVLQCAKHNAQIYGVQDKITWFEGDCFELLRNQLKDLAPYSVIFASPPGVVSFGPGYRSDKVFNLRTMEPYSLSTLYREFAAFSEHMVLFLPRTSDVKQLAKVVKDGQQATVMHYCMEGASKALCIYYGGFNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRX0</accession>
    <name>A0A2I2GRX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710939.1">
        <property type="nucleotide sequence ID" value="XM_024852806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRX0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRX0"/>
    <dbReference type="GeneID" id="36560504"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471047"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121911" checksum="6DCE14F1E681181D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS54</accession>
    <name>A0A2I2GS54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_433213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711008.1">
        <property type="nucleotide sequence ID" value="XM_024848425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS54"/>
    <dbReference type="GeneID" id="36556124"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433213"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="77" mass="8663" checksum="7AADA42B32F4B19F" modified="2018-02-28" version="1">MVIGRRFLRPSSIRGTAARVGQGGSHPVFWRMRTARSLIIITEGVDGDSVEAEESAPETNFTKERKYEARVEREKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQR3</accession>
    <name>A0A2I2FQR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">P170DRAFT_370598</name>
        <name evidence="23" type="ORF">P170DRAFT_370616</name>
        <name evidence="24" type="ORF">P170DRAFT_370631</name>
        <name evidence="22" type="ORF">P170DRAFT_370680</name>
        <name evidence="21" type="ORF">P170DRAFT_370693</name>
        <name evidence="19" type="ORF">P170DRAFT_370820</name>
        <name evidence="20" type="ORF">P170DRAFT_370851</name>
        <name evidence="16" type="ORF">P170DRAFT_370875</name>
        <name evidence="18" type="ORF">P170DRAFT_370937</name>
        <name evidence="14" type="ORF">P170DRAFT_371011</name>
        <name evidence="15" type="ORF">P170DRAFT_371018</name>
        <name evidence="13" type="ORF">P170DRAFT_371060</name>
        <name evidence="12" type="ORF">P170DRAFT_371129</name>
        <name evidence="11" type="ORF">P170DRAFT_371178</name>
        <name evidence="10" type="ORF">P170DRAFT_371198</name>
        <name evidence="8" type="ORF">P170DRAFT_371296</name>
        <name evidence="9" type="ORF">P170DRAFT_371306</name>
        <name evidence="7" type="ORF">P170DRAFT_371386</name>
        <name evidence="6" type="ORF">P170DRAFT_371405</name>
        <name evidence="5" type="ORF">P170DRAFT_371506</name>
        <name evidence="4" type="ORF">P170DRAFT_371552</name>
        <name evidence="3" type="ORF">P170DRAFT_371602</name>
        <name evidence="2" type="ORF">P170DRAFT_371613</name>
        <name evidence="17" type="ORF">P170DRAFT_486871</name>
    </gene>
    <organism evidence="17 26">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 26">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000033">
        <property type="protein sequence ID" value="PLB42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000032">
        <property type="protein sequence ID" value="PLB42762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000028">
        <property type="protein sequence ID" value="PLB42777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000027">
        <property type="protein sequence ID" value="PLB42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000025">
        <property type="protein sequence ID" value="PLB42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000024">
        <property type="protein sequence ID" value="PLB42823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000022">
        <property type="protein sequence ID" value="PLB42850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000022">
        <property type="protein sequence ID" value="PLB42861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000021">
        <property type="protein sequence ID" value="PLB42870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000020">
        <property type="protein sequence ID" value="PLB42894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000019">
        <property type="protein sequence ID" value="PLB42910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000018">
        <property type="protein sequence ID" value="PLB42925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB42994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370598"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370616"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370631"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370680"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370693"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370820"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370851"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370875"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370937"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371011"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371018"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371060"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371129"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371178"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371198"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371296"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371306"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371386"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371405"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371506"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371552"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371602"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_371613"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_486871"/>
    <dbReference type="OrthoDB" id="3470073at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB42777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB42816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB42823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB42850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB42861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB42870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB42894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB42910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB42925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB42943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB42954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB42964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB42974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB42985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB42994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB43030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PLB43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PLB43066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PLB43078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="177" mass="19580" checksum="94F460429DF08DFA" modified="2018-02-28" version="1" fragment="single">IPKFDDRFARQNRCEPPPEFPLASPYSGIVHHLSGPHIYALTQIHPKTSGSVDGAPREGAPTSVRFHCAHGFDTRTLAVRAEARSSVQAGSIAPPAIRCPEGHYIPGAFDLPPKPTLARPRGSTPARMPAEPRGRVWSQALPFQQFHVLFNSLFKVLFIFRSLYLCAIGLRPVFSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRY8</accession>
    <name>A0A2I2FRY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_370234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698679.1">
        <property type="nucleotide sequence ID" value="XM_024844944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRY8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRY8"/>
    <dbReference type="GeneID" id="36552644"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370234"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="30"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="293" mass="33796" checksum="0AF7F1FFFC1FB2FB" modified="2018-02-28" version="1">MPPKKRVLISYGVDVDAVAGWLGSYGGEDSANDISRGIWAATVGTERLLKMFAKYGIRTTWFIPGHSLESFPEEMAKVRDAGHEIGLHGYSHENPVDMTREQQRDVLEKTVDLLTKFTGKRPRGSVAPWWETDAEGVAMLQDYGVEYDHSLSHHDCQAYYLRTGDEWTKIDYTQKAETWMKPLVPGKVTSLVEIPGNWYIDDLPPMMFIKSAPNSHGFVNPRDVEDIWRDHFDYFYREYDEFVFPISIHPDVSGRPQVILMHERLIEYFKSHDGVEFVAMEVICDDFKRRNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRZ3</accession>
    <name>A0A2I2FRZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphatidylglycerol specific phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_441805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698710.1">
        <property type="nucleotide sequence ID" value="XM_024850404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRZ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRZ3"/>
    <dbReference type="GeneID" id="36558103"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441805"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000052">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="501" mass="54987" checksum="9BF0CD02E8C24525" modified="2018-02-28" version="1">MQWDQSAGTRGTEDPEKLPMLKHLAPDDPVTPHALLGIKTPFWEPRTPASTISWRKSVCITLLLLAMSILSLVTFFSLGVGISGLPHGPAPSAQSPIKNVVVLVQENLSFDVFAGGLTYSDAIDGLVKTKYCNPANVTDPTSEKVCAQPVAKNVAPDDPDHSISGGNQQVYGTYHPNYKNDVPDMQGFVTEQIASYGLHTDLSRAAEVINYYTPDNVPVFSAIAENFVLFDRWFASVPGPTNPNRAYLTSGTSHGHGTNDDDFLTSSLPQVSIFEQLSNANISWVNYQNTTGSGFLPDAQFYKWTAQSGKDKTNVQPLDRFFADAKSGSLPQFTWINPECCSYMSFHPPSPINMGEGFVKSIYEAVRSSPQWNETLFILTFDEHGGFADHVAPPENVPSGDNLTYSEKAKDGRSTTFHFDRLGVRVPTVLISPWVGKGLVQNSPSDQSGEFTHTSILKYLAELWNLPVLGPRVEWSPNFKSLITNSFRDDTPQTLPSPATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSK3</accession>
    <name>A0A2I2FSK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_441044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698888.1">
        <property type="nucleotide sequence ID" value="XM_024850220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSK3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSK3"/>
    <dbReference type="GeneID" id="36557919"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441044"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000043">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="88"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB43586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="402" mass="44170" checksum="B7B3D87FC0B1B64A" modified="2018-02-28" version="1">MKRLQLLRWSSSALRTPRARTGGRLQQHLSYGLRHQSTAGSSALPVENDPLVDEQLVGSHLPPSHPQKQSRHIYPSPPVEAARESAKLAALHARLYLPSRLPLETLARSLVDSSADPSPNFNNESLATLGHDLLTHYTSEHLLCTYPRLPLTVIFAAMYAYVGPKTLAAMAREWGVEMAAVPGGEVDPGLLQFKRVLPGTDLDAEPITGTQRPNEHRKSWRKSVTSRVVYDNEFGDPAKMSGEEALNTQGVTAEQASATFVRAVMGSIYLHAGRPAAKRFFEQHFLSRHLNISELFNFSQPARDLSRLCARENFEPPVAKIISETGRKSRHPVFNVGIFSGQDKLGEGAGASLLEARSRAAVAALKGWYLYSPLNVRVPSSMEEEGAAPWKPVHVDLGEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSU6</accession>
    <name>A0A2I2FSU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_430751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699020.1">
        <property type="nucleotide sequence ID" value="XM_024847975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSU6"/>
    <dbReference type="GeneID" id="36555674"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430751"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="388" mass="43468" checksum="895BDFA95D3ABBC7" modified="2018-02-28" version="1">MWLYRGAQSAVFYYATCTPCAMSVDRRKRKKEAARSQREKEKLDAIVTDQPRPFPQPTAFRTNQGWKEEIALGPGPPARRGGHRNAHRRTDSWKSDARSAEDVDRTGGPAQKKDKGGLMQPVSDRWNRMRYQREDEPLWGEDVEVKGSSVGISGQGRTHAKEPKYYIARVPPVNDLHPPIVSGPKSRAETRWMLQPPPSARVMAGKERTNPSAQTTQPREKKASPTPPGMARNYQLPPISTQTSVKKKTLKPSPTLISPNDAHTPTTSKSKPDDHRSARSSSPTASAYGRDESNFVVSRSLHSRCDSSMLMSSDSEMESPRVSMHSPQTPVSRPGSKETDGKHFRPAILPRDTTSKVQMLHVEINEPHDEVGLGQLEQIRPWRWSMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSW9</accession>
    <name>A0A2I2FSW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HLH transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_441166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699008.1">
        <property type="nucleotide sequence ID" value="XM_024850251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSW9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSW9"/>
    <dbReference type="GeneID" id="36557950"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441166"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="146"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="365" mass="38973" checksum="8754A0144953DD42" modified="2018-02-28" version="1">MSGEFTIKEQVSVDGTDAFALPPAAMSPSKLPNAASRRSSKTDSAYLPASPTSPEFGPGRTASSTRQAGVKRSLEDFELPPPPTRTRKIIQMKPKTQNSPKPAPASSKSSTKESNKNAPNNANIATPAASKKKQPSATSAAGRKIARKTAHSLIERRRRSKMNEEFGTLKDMIPACKGQDMHKLSILQASIEYVNYLEQCIQDLKMAGGQQSPMLQHMPPGPPSPTSPEALPEFTGSTYSASVSPDLYPISNQMNETSPVFSPQGHVPSAGIPSEVAPSVLPSPALGPMQSSPSIEPQYRNPSSADVDHEASAALLMLNRDCRQATSLADGERSGSISGPPEGQEYSHPDNQRRMGMSVKELLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSY0</accession>
    <name>A0A2I2FSY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinate utilization oxidoreductase QutH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_468519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699045.1">
        <property type="nucleotide sequence ID" value="XM_024852560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSY0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSY0"/>
    <dbReference type="GeneID" id="36560258"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468519"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="390" mass="41681" checksum="9D3B1E9C8E46A9D9" modified="2018-02-28" version="1">MSPINIIIVGAGLIGPRHAQSVLANPSTHLVGLIDPLPSAASIAQSLGTSYYPTIEACLQATRTTASSTPHAAIICTPNHTHVAVAQQLLSENLHILLEKPVSHDLPSGASLLRFSQQPSTSHLKILAGHHRRFNPYITTTKSIIDSGSLGTIIAINGLWTLFKPASYFEGSGSWRSSPSSGGVCAINLVHDIDCLQYLFGPIVRLHAEKTLPQRPTPPHSADEGAALTLRFGSGVVGTFLVCDATPAPWSFEAGTGENPSIPRTGGPGGDFYRILGSRASLSVPDMTRWSYDGRAKSWTEELVAEKVRVEGEEKRPFDLQLSHFVDVIGGRAQPRCSLVEGLRALVVVQAARRALETGETVDVGELEGELDSRCKYAVSDSRMNVVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT72</accession>
    <name>A0A2I2FT72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_514130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699116.1">
        <property type="nucleotide sequence ID" value="XM_024855176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT72"/>
    <dbReference type="GeneID" id="36562882"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514130"/>
    <dbReference type="OrthoDB" id="4509965at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24151" checksum="697D125C0AAD9A98" modified="2018-02-28" version="1">MDLSTSNPSINQTPTPTRDILTNPPAFPASPATTTLFTNPPTTPIQTIQTYETPDRQLTGIRVTWMNGDRARLGVCGEDLGTSTSTSTSTGIGTGISTSTGATDSGSGAGAGVGIGNTSASASTGAETGTGTGTGTEISTSTKPQTIRKTFAFDRQERIQIMYVYVGSTQVDGFWFVTNKQKSFFPGRSSERREMSDLGSGVLVGMEGREKLDEEGRVEGILGLGVSFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT82</accession>
    <name>A0A2I2FT82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_393818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699128.1">
        <property type="nucleotide sequence ID" value="XM_024846033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT82"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT82"/>
    <dbReference type="GeneID" id="36553732"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393818"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014161563" evidence="1">
        <location>
            <begin position="19"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="289"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="792" mass="87386" checksum="C5325244D530840B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU60</accession>
    <name>A0A2I2FU60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haemolytic enterotoxin (HBL)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_450366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699485.1">
        <property type="nucleotide sequence ID" value="XM_024851119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU60"/>
    <dbReference type="GeneID" id="36558818"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450366"/>
    <dbReference type="OrthoDB" id="4961018at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43951" checksum="E52DB6C87C24A93E" modified="2018-02-28" version="1">MTVPPAYSTEDAPPSYDEVAGKVDKLVGGSTSPQKYLDVAASLTDEERKVLQDGAEEHNPIKTDEDKKKLSLGAAVTMSTDEVVGKLKEDASKASAAVVAIDGSFTALQVQIASIDQLEQTNFLTQLNNHKTSYQDVLQQSRNLAADISQYGSSFDQLIVPLCADESLTVEQRTEQIDRFITKADDFETQGNEINKNFESLINNFVSFTSQFSQWGKDKEQQLNDEIAEIDNQLVELTKKLADLQTSLISLGVGLGVGLTVAGIGLALSGPVAPFILIGGLIFAGATAASVAGIAIAMGVVANQIDEKKRERAEKADEIDKIQLARRNLEDMGDSQLIVFRDNVKVLQSYWTSMQADAREIKGWLQNGADLASMPSYMKSALDNAVTVYASMAQYMDEYAKGTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUD4</accession>
    <name>A0A2I2FUD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_430138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699534.1">
        <property type="nucleotide sequence ID" value="XM_024847933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUD4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUD4"/>
    <dbReference type="GeneID" id="36555632"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430138"/>
    <dbReference type="OrthoDB" id="2103397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="245" mass="28309" checksum="C8A82B33CF810A43" modified="2018-02-28" version="1">MYENVDKIFHIRPSDNMKKSGWFLHSGSETPVPKHILPALESFTETRISDASWKGIQDARVRMVILTVLANRKRNGHVQNCRGIRTLPPSAYESLKFETDQRVELLWTYRRRPVRFVGTMRYCLRRLDEPYPLFIIDDNLHRDHTLAYLDMIHHARKEAGLPGRTIYGLTTDSYEWYFIRVEKDATYTTQLLSGYLSQWEDIVSAIGAMIDHAAGCQSGITLGPADLDWHMCILTPSRRALRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVB3</accession>
    <name>A0A2I2FVB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_468213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699864.1">
        <property type="nucleotide sequence ID" value="XM_024852540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVB3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVB3"/>
    <dbReference type="GeneID" id="36560238"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468213"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="279" mass="31362" checksum="5D2D4A395B444528" modified="2018-02-28" version="1">MDEILGPEPPEHLNEPSEPEHVTFDLKRELAEMIDADNLHGEISSFHYLMRPIFEGHHVLAMGPFHSRHTFLFICILNLINTSTNRSPTTSSSLSPLCQSIVLTSSPSFSYVLHKIANRVGSHFHPPIHTHCCFHNRTTGAQTEATELSTSPLPEIAVDTPGRMLYYLQRGALESRNLGIIVLDGVDEPFDRGFGEQVVDILRLCSCSCSLGGERRAKKMQVVVHVGDMCRWREIWGLIGEFVGGGKEVVRVWDESVLRQTVVLWPWRVADWVRLGANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVS9</accession>
    <name>A0A2I2FVS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_429450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699988.1">
        <property type="nucleotide sequence ID" value="XM_024847890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVS9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVS9"/>
    <dbReference type="GeneID" id="36555589"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429450"/>
    <dbReference type="OrthoDB" id="5365739at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="346" mass="38751" checksum="9540367BCA6BDD7E" modified="2018-02-28" version="1">MLQHRATLWQSRFGRLLDGTSPLVRQFSASQGQATDGPRQPRHDNIDQSRFPSSHSRLQRTGVQASTSRSKPANSERPRPRRVFDARSLAAPQAGGQPANVIRNPRLRNPRSGSPAYGRGSRPPTKSAALRNKKGPRTRTARPRDLDEGEDVQKVEIEEGYRKLAERTKISPSHYNPKAPMLSNLERTWPSFPTNSGAHHSTIIDKLLRISDRTPNGYVPPQELGRRLFNGQYVHFLDEEEKSQALVEASKLSQQRADEYSQRKGDLVEPEKVEFEQINTDDRGVLLQSLVQGKYTKTEPLGKVSVVDGVIQNLANNETYQAAGKSSQFVSKLESLMASSRPMKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVU4</accession>
    <name>A0A2I2FVU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">High osmolarity signaling protein SHO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Osmosensor SHO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P170DRAFT_367142</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700054.1">
        <property type="nucleotide sequence ID" value="XM_024844791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVU4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVU4"/>
    <dbReference type="GeneID" id="36552491"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367142"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1130" mass="121956" checksum="5E7C863F294A3086" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW15</accession>
    <name>A0A2I2FW15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_366297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024844752.1"/>
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    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
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        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="355"/>
            <end position="373"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="396"/>
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    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="157"/>
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    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
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            <begin position="237"/>
            <end position="328"/>
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    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="352"/>
            <end position="394"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14378"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="445" mass="50079" checksum="58C1F788C3ABE66E" modified="2018-02-28" version="1">MGAGAVLEPLVVVVLLFGGTWINRSASSFSSARRPRRRSGAWPRDGSPDSVESGIASPTAKDGLLARRSTSPSLLQPELKSWHQRQIGLLSYSVEVTSPNTLVFQDRFLSRLLRKLPFLAECWYWALVYWTYQLGRAFTAVTLREGTVDVARKHALQLIRIEESLGIFWEIPIQQFFLRHTKLMTWTNWIYSFIHIPGTIAFLVWLYYYTTTRNRFDESQPGKPRGMMGGSPAGPLLYQARRRTLAVCNLLAFVVFTLWPCMPPRLLSDKTAEGPDGELGRSYGFVDTVHGVNGAGSVWTENRFCNQYAAMPSLHFGYSLMIGLTIMTIPLPAHHRRSIGLTRYFGLRIPSWRRLACLLLGFSYPFIILAAIVATANHFILDAIAGAVVCALGWRFNGILLNLLPLEDYFLWVVRIHKPEPADGFGSADGWFDDEATPEFVAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX61</accession>
    <name>A0A2I2FX61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_416295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700537.1">
        <property type="nucleotide sequence ID" value="XM_024847113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX61"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX61"/>
    <dbReference type="GeneID" id="36554812"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416295"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="43"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="293" mass="32788" checksum="FDA3491AF41C4619" modified="2018-02-28" version="1">MQSTRLALRGASSVRSFSTSRILRSDLSFQVFGPEKEEASRSPIVFLHGLFGSKQNNRSISRALARDLNRQIFTLDLRNHGQSFHAQEHNYSAMAEDVTKFIHQQNLNQCVLIGHSMGAKTAMTVALDSPGLVSALIPVDNAPVNAALKSDFGKYVQGMQHVEAENVTKQSDADKILQGYEESLPIRQFLLTNLVRSEEDKTMKFRVPLSVIGSSLDQMADFPYQEPGQVTYEGPTLFVRGTKSRYVSNETIPAIRKFFPRSQIADVEAGHWLISENPEAFRQVVVKFLQETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX69</accession>
    <name>A0A2I2FX69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptic vesicle transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_391930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700540.1">
        <property type="nucleotide sequence ID" value="XM_024845953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX69"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX69"/>
    <dbReference type="GeneID" id="36553652"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_391930"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="88"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="519" mass="57283" checksum="BE3F6C5522919411" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXJ8</accession>
    <name>A0A2I2FXJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pex16-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_449073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700660.1">
        <property type="nucleotide sequence ID" value="XM_024851014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXJ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXJ8"/>
    <dbReference type="GeneID" id="36558713"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449073"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="7">
        <location>
            <begin position="591"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="919"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1129" mass="128074" checksum="B95969E12E5D661B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXK4</accession>
    <name>A0A2I2FXK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LEM3/CDC50 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_449061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700649.1">
        <property type="nucleotide sequence ID" value="XM_024851012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXK4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXK4"/>
    <dbReference type="GeneID" id="36558711"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449061"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="401" mass="45123" checksum="541586D5C5FF60B8" modified="2018-02-28" version="1">MSHTEVDQTGSLGEQERRGDSDGDKKPRNKRPANTAFRQQRLKAWQPILTPKSVLPLFFIVGIIFAPIGGLLLWASSQVQEISIDYSECAEKAPRKGHEEIPNRVSSSFKSSGQIAPTWQRRDEHNVTYCRLIFDIPDTIGPPVFLYYRLTNFYQNHRRYVKSLDVDQLKGKAVDNKTLDGGSCDPLKLDPSGKAYYPCGLIANSQFNDTIYSPQLLNDDRVEAEPYLMTNKGIAWDSDKELIKKTQYKPGQVVPPPNWHDRYNYTDEIPDLHENEEFMVWMRTAALPTFSKLARRNDTTSMAKGTYQLDIALRFPVTEYGGTKSILISTRTVMGGQNPFMGIAYVVVGGVCVLLGALFTVAHLIRPRKLGDHTYLTWNGEQEGTAAIATGRDNRFGAHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXT8</accession>
    <name>A0A2I2FXT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_244121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700742.1">
        <property type="nucleotide sequence ID" value="XM_024842968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXT8"/>
    <dbReference type="GeneID" id="36550667"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_244121"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="129" mass="14179" checksum="22665EFCABF3683F" modified="2018-02-28" version="1">MHHSWLSVCFPWELRRGPLLVCSKVGSPRSRISSAACNGAYSSRVFRRKVAKSDAKRGRAAAFVLAAGIALLVHDRGLETSPIRTRSPRAFSAMMSFAVTPPRGDQRCFPKGADDALCRSSRSSHHLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYA8</accession>
    <name>A0A2I2FYA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_413998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700921.1">
        <property type="nucleotide sequence ID" value="XM_024847000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYA8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYA8"/>
    <dbReference type="GeneID" id="36554699"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413998"/>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="563"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1115"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1149"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1172" mass="128705" checksum="F481A18A0D0A6480" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYH4</accession>
    <name>A0A2I2FYH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_249959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700986.1">
        <property type="nucleotide sequence ID" value="XM_024843018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYH4"/>
    <dbReference type="GeneID" id="36550717"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_249959"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="90" mass="9962" checksum="2E57E553CE7F2575" modified="2018-02-28" version="1">MWQRGKEQEQWFSSSGSSFSPEIGFPRKGSPVWLQVQALVVPPGGRAGRSTPGGSLVGILIFMVVLRRQQRMIRPSIWGEVNRIVVRGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYM9</accession>
    <name>A0A2I2FYM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_478673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701037.1">
        <property type="nucleotide sequence ID" value="XM_024853584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYM9"/>
    <dbReference type="GeneID" id="36561282"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478673"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="194" mass="21704" checksum="6F36D8A1C516EB92" modified="2018-02-28" version="1">MSLRELKKLSTSYWARRVHGGMTQTAVVVVNDVDIFPPRFIVNERANINSRGYRISPFTRICRNSPAEVSTRLDSNKAPKDTRGFTWRLLPLASDVKDMELRPDKEVFPQIIILRLSFPRDMIVALYLQEPYRVGPVDAYHGIGTPNPLGNPLCTPPEPAQSPVKADSQTDGEDATQTPLGLPRSTPQEDSDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYT8</accession>
    <name>A0A2I2FYT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_428976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701091.1">
        <property type="nucleotide sequence ID" value="XM_024847868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYT8"/>
    <dbReference type="GeneID" id="36555567"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428976"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="291" mass="33478" checksum="14E55C5999202FE2" modified="2018-02-28" version="1">MSTPLDKSTLSGITRINVGTPETAFDVHIELLRSCSPFFDRLFKDHTLVEIQTNPVPLPNEDPDLFGDLISWLYRGTLSQYLVAQDSAFFLFRLWILGARFEMPGLQNYVISHFLVVMNTQPGGVYDKEKIDYVYDNTQPGSPLRRLAVDMWARNGSQAGFPELLHSMPHAFLGDLCGALLEQRNVKTEAEISLEDFVRRYYVPDRVVREQPNKRLLEDEPEKSVEVESNVPQRATPAQMQRRKIITPKSRLHSSPGPARFIANEHREGGDSDGMWRRRDSDETWKRRRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZJ4</accession>
    <name>A0A2I2FZJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_439734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701346.1">
        <property type="nucleotide sequence ID" value="XM_024849908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZJ4"/>
    <dbReference type="GeneID" id="36557607"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439734"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="158"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="266"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB46044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="416" mass="45584" checksum="D30524399EB92195" modified="2018-02-28" version="1">MSLSSVFGLFTTTEIPDSPASAVYSKTASTGEHVPHGPSQVKTDRDAHAPNAASIADEEEPRPPYLHAMLAGGIGGTCGDMLMHSLDTVKTRQQGDPHIPPKYTSMTSSYATIYRQEGLFRGLYGGVTPAFLGSFPGTVTFFGVYEFTKRRMLDAGINPNLAYLSGGFLADLAASIVYVPSEVLKTRMQLQGRYNNPYFYSGYNYRSTTDAFRTIVRQEGFAALFYGYKATIFRDLPFSALQFAFYEQEHRMAIEWVGSRDIGLGLEILTAATAGGMAGVMTCPMDVVKTRVQTQQNPETASPPKGATEPASIKESPRQHAPSQTTSSNLRTHSRPISTSPPSTSVPPPGTPRLDTTSFFTGLKMIYRAEGIQGWFRGVGPRGVWTSIQSGTMLVMYQYLLKKFEEYQSLEETNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZL3</accession>
    <name>A0A2I2FZL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase, FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_439703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701318.1">
        <property type="nucleotide sequence ID" value="XM_024849902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZL3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZL3"/>
    <dbReference type="GeneID" id="36557601"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439703"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014142005" evidence="5">
        <location>
            <begin position="23"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="494" mass="52339" checksum="EE9800E361B54D64" modified="2018-02-28" version="1">MATSSLGVCCLTLASLGPGKVAFPDTIPYQSSQESYFAGQNSELQPLCVVSPESAEEVSSIVTSLVVTASALPAHEQAGCHFAVRSGGHNSFAGASNIDQGVTIDLRALNDVQIASPSESDDDHPPTVFVGTGATWGEVYALLDPAGLPVAGGRAAQVGVGGLTLEGGISYFSPRYGWTCDNVVGVEIVLANGSIVHLDEAQHLDTLAALRGGGSNFGVVTGFELRAFHQGPIYGGHVYYGMETIDAQLRAFAELSDPIVGSYDEYASLITSFGFAGGQGAAVVNSMVYTGEQRGDGERPPVYDPLFDIPQLFSTVRVAPLHEVATEQGSFSQSGKRQLGIVTTHDSTVPMLNATYLRWNASLTAVQDVSGIVWSISLEPLPAAIYARAPTRNAMGLSDSEGSLVVTVLSATWDEAADDARVEEAARMLFAGIEADAHALDAYHPFVYLNYAAQWQDPIASYGRQSVEKLQRISQELDPKGVFRQMVPGFKIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZU1</accession>
    <name>A0A2I2FZU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_415059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701454.1">
        <property type="nucleotide sequence ID" value="XM_024847046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZU1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZU1"/>
    <dbReference type="GeneID" id="36554745"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415059"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.400.10:FF:000001">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="697" mass="77242" checksum="D86768B5120ED559" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G020</accession>
    <name>A0A2I2G020_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mcm2 3 5 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_512761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701516.1">
        <property type="nucleotide sequence ID" value="XM_024855019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G020"/>
    <dbReference type="STRING" id="1392250.A0A2I2G020"/>
    <dbReference type="GeneID" id="36562725"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512761"/>
    <dbReference type="OrthoDB" id="4721035at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="93701" checksum="10445F7F8C4047E3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Q2</accession>
    <name>A0A2I2G0Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_511231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701766.1">
        <property type="nucleotide sequence ID" value="XM_024854865.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2G0Q2"/>
    <dbReference type="GeneID" id="36562571"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511231"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="31"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="912"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2378"/>
            <end position="2455"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="912"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="944"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB46464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2458" mass="270063" checksum="CB143488F4B70E4A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0S6</accession>
    <name>A0A2I2G0S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cellulase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Carboxymethylcellulase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellulase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_363756</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701748.1">
        <property type="nucleotide sequence ID" value="XM_024844603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0S6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0S6"/>
    <dbReference type="GeneID" id="36552303"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_363756"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014146260" description="cellulase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB46446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="397" mass="43125" checksum="9C7B5F1DA762BC5C" modified="2018-02-28" version="1">MKFISLLAVLPLVFAAPNKRDSGFVWFGTNEAGAEFGQNTIPGDLGTHYIWPDLSTIKTLHDAGMNIFRVAFMMERLIPEKLTGTPDAKYLSDLKATVKGITDLGDYAIIDPHNFGRYYGNVISSTSDFAAFWTTLAKEFVNNDKVIFDTNNEYHTMDQTHVLNLNQAAINAIRATGATSQYIMIEGNSWSGAWTWVTVNDNLKALTDPNDKLIYEMHQYLDSDGSGTSSTCVSSSIGQERVAAATAWLKENNKKGFLGEFAGGANSVCQTAVQGMLSYLGQNSDVWLGAAWWAAGPWWGDYIFNMEPSGGTGYTNYLSLLKPFFVGGDGGSGTTTTATRTTTATATSTRTTTATTATSTAVAKQYEQCGGNNWSGPTVCVSPYSCQKVNDWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0W3</accession>
    <name>A0A2I2G0W3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_438285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701827.1">
        <property type="nucleotide sequence ID" value="XM_024849562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0W3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0W3"/>
    <dbReference type="GeneID" id="36557261"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438285"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014197833" evidence="1">
        <location>
            <begin position="17"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="210"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="644" mass="69085" checksum="70D100974B8CE621" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1M8</accession>
    <name>A0A2I2G1M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_222165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702080.1">
        <property type="nucleotide sequence ID" value="XM_024842867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1M8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1M8"/>
    <dbReference type="GeneID" id="36550566"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_222165"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="102"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB46778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="693" mass="74624" checksum="CB686341D1611B0E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G247</accession>
    <name>A0A2I2G247_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_362164</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702247.1">
        <property type="nucleotide sequence ID" value="XM_024844514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G247"/>
    <dbReference type="STRING" id="1392250.A0A2I2G247"/>
    <dbReference type="GeneID" id="36552214"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362164"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB46945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="447" mass="49964" checksum="2514805869332EC2" modified="2018-02-28" version="1">MASSSSNVVGVHYRVGKKIGEGSFGVIFEGTNLLNNQQVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCNRRFSTKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPSTKAANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFLYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTAIKDLCEGYPEEFTKYLTYVRNLGFEDTPDYDYLRDLLTQALKNAGEVEDGEYDWMKLNNGRGWEYKSYSSQQHLHNNGLPNTSARELHAQQLRGSQRPGVTADRLNAAQPPPPSPAKAGAGKTRERPNVAGGMPNKRQSGGMETATPTASTQAQFQNSSANIPGRIGSPTNPTRNSQQAQGAPGNSNEPQPTFVQKMMKALCCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2A1</accession>
    <name>A0A2I2G2A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_231032</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702303.1">
        <property type="nucleotide sequence ID" value="XM_024842896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2A1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2A1"/>
    <dbReference type="GeneID" id="36550595"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_231032"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16 20" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="1101"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1227"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="682"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB47001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138806" checksum="CB655D3F130A066B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2K9</accession>
    <name>A0A2I2G2K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_466452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P-Pant transferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702426.1">
        <property type="nucleotide sequence ID" value="XM_024852417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2K9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2K9"/>
    <dbReference type="GeneID" id="36560115"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466452"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000023">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="6">
        <location>
            <begin position="148"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="336" mass="37213" checksum="69C4BD969144E872" modified="2018-02-28" version="1">MATEQSDQYPLTRWYIDTRPLTSTISTLPLLETLQPADQETVQRFYHLRDRHMSLASYLLKYLFIHRTCRIPWSTVKLSRTPAPHNRPCFIPSVSDASIPAIEFNVSHQASLVALAGTTISPAAVNSSASNPISSTPSPSTYPGNTPQVGIDITCVNERRNTRSQPPPSSIPEFTSFVDIFAEVFSARELATIKSLHGIPPHLNTTDAKKVEYGYRLFYTYWALKEAYIKMTGEALLAPWLRQLEFTDVKVLEPAGESGDECWNGPYTGVQTWLDGKKVEGVRVEVLAFQEDYLIAAAARGGGIGDGGEGRWLAMEQIDIERDAVNGLGHKLLAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2N4</accession>
    <name>A0A2I2G2N4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_511778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702434.1">
        <property type="nucleotide sequence ID" value="XM_024854921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2N4"/>
    <dbReference type="GeneID" id="36562627"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511778"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="223" mass="25184" checksum="E45DFD5CD0118B7D" modified="2018-02-28" version="1">MHTTSTPLAEVDPSKIKIIRGISYSDASSIFEVDLDGQKYALKLYHDEGEPGYSKKGRDLNRFRCEYGAYQKLIASGACDSGFVPKCYGYIDRVDPAAFHPAFDNFAQDKMKPRAILLEYLPNAESLNCVKYSDTLFPQAIEGMKEIHRAGVYHYDVWPRNLLLVRGTPDRLVWSDFDVAMTFTDFGPQQLARCEHEIALVQGIGDALREDQAEGLPPNTKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Q2</accession>
    <name>A0A2I2G2Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_235392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702453.1">
        <property type="nucleotide sequence ID" value="XM_024842918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Q2"/>
    <dbReference type="GeneID" id="36550617"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_235392"/>
    <dbReference type="OrthoDB" id="5279661at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="185" mass="21707" checksum="7F5A821679E40763" modified="2018-02-28" version="1">MVGINSPVFPNLGSNLVFLFLSKSVLFLLLLLLLYPLIHHSITVSPSELRSINSPPKKEKEKEKEKEKEMPHTENGYFYYSYNYRCPWTNQADNTQGIDDTFYSAYYTRHKPDHAAQNAWFKDCVMPAVREDIRKWLETVDRNTLGRTYDRFKQSNVRQLEFRPCVALPTHSEGRLKGRPYGREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3C2</accession>
    <name>A0A2I2G3C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_466639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702673.1">
        <property type="nucleotide sequence ID" value="XM_024852432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3C2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3C2"/>
    <dbReference type="GeneID" id="36560130"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466639"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014179697" evidence="2">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="166" mass="18456" checksum="B666A5D59B46A6AC" modified="2018-02-28" version="1">MASGLIFDPLALLRVIPLASSTGTLVCATGELTHNSAWTQPDMRKKGDSLLPRWYSYVFPRTVSLVLVLNLTSIGSAAANLLTSGPRPRPWPLSRITFYWAGLFSAISHLVFVPWVAPRIQRIVEDLEGEREPTQEMEAWLGYHRIRMLLADAPAWLAFVGAVLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3I8</accession>
    <name>A0A2I2G3I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702742.1">
        <property type="nucleotide sequence ID" value="XM_024849761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3I8"/>
    <dbReference type="GeneID" id="36557460"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439098"/>
    <dbReference type="OrthoDB" id="3545468at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014199117" evidence="1">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="206" mass="22345" checksum="5AF5CB72C6C85BFF" modified="2018-02-28" version="1">MIPAILTTFSVLGAAYASSVQPVVAKGGCYNINSYYPYTGTTGYFMFTVDGCVNTTATDKACNIEGFRDTTVGTGDNKGHMGIGYVGDQAITPLLCDDASPSVIDACVSGDNGCEFQTANISSSTGMFDWGLSAQESIKVDFYHHVVDGKQQDGLFVGAENVTSWAIKRYPADSHFKVPYWLLRWLGEDKELKDGEFQTFLKVGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4I1</accession>
    <name>A0A2I2G4I1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_437506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703071.1">
        <property type="nucleotide sequence ID" value="XM_024849381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4I1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4I1"/>
    <dbReference type="GeneID" id="36557080"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437506"/>
    <dbReference type="OrthoDB" id="4499526at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46577" checksum="E2D5D9F78EA578B6" modified="2018-02-28" version="1">MAASAKLTPVGDTHRVDVKDYDSYAWVLLEDHPLRSYPTKYPPGLFNFLRRWYATVRGWWSERGLSLVCLFVMFLMVIQFLAHLPYGVSYLLATDLSDQVGLAQWPAEFGGRPSACISYEPRVHWDAVDRALNAGCAGIKADVWVQGDEVFVGDSSSVPGPNDTLDHVYLEPLMAKLDARNPAVVSSVSDNSPKPVGLFDHDSTQPFMLFLRLQSQMSTVWPHLVLRMASLSQKGYLSYTDGVQVIPRPVTIVVTGLTSSEVDFVKDIGHDGINGSILFEKSPDLDATGNNPENDNSRESENPSGSLQEPSSGLPFQMFSVTINFRDSIGSPRGGRFSIQQIERIKTQVHNAHQRGLRIRYEAIPCLPRMLRRIVWRILVHEGADCIEVDWTQCEGGWWRSLFTIGRRDGRSHGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5X5</accession>
    <name>A0A2I2G5X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_510910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703577.1">
        <property type="nucleotide sequence ID" value="XM_024854827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5X5"/>
    <dbReference type="GeneID" id="36562533"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510910"/>
    <dbReference type="OrthoDB" id="3446576at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34266" checksum="34F54879E089A93D" modified="2018-02-28" version="1">MGAIVTSDLAVVSDGSTIYVYYQNDANEIREVTSSDGSKWTETSSAVATKLNAGGSPITAYYVKNDGTAGFKSSIHVVYLDASGILHEVVKTPIDNTKWEERDLSDDIKKAPIQTSRLASGVCHDSSSGAHQWIFFEKLDSESGNPQVAELRSGSQSSFKWTYQVILPENSASALPGTQLATNLTNPTNQLYFQDHDGNITEYIGGYDSWNDHKQLLTNDKVEINTPLSTATSSNEDKPYIFYVSKSTPLMIMCYDHDKSTEVAKFYPGTKLDSISVSGKVYLFHKPLEHPGSVWTRVFDGSSWKMGAQVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G613</accession>
    <name>A0A2I2G613_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Arginase</fullName>
            <ecNumber evidence="3 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_510943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="3 11"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703612.1">
        <property type="nucleotide sequence ID" value="XM_024854832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G613"/>
    <dbReference type="STRING" id="1392250.A0A2I2G613"/>
    <dbReference type="GeneID" id="36562538"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510943"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB48310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="320" mass="34080" checksum="D1B120C4E24B57C6" modified="2018-02-28" version="1">MASPKKLMGKAAQSLAIVSAGFCRGAPKAGTDAGPSAILDSGLFAQLQRHFTRVQLDNDKLDGADLPQTRDPDFAGMKNPRAVSAATKYTSERAYNHSRNGSLVLTLGGDHSNAIGSLTGASKGLRERTGSDFAVICVDAHVSINTPETSPSGNINGMPLAFATGIAKTKGDGIFNWIQKEHQVDVKRLVYVGTRDVDDAEKETIKAHGIKVFDMERIRRNGIENVMDEVLDYVGSSVPIHLSCDIDALDPEWGPSAGHLVPDGLALEEGQYIARRVSATNRLAAMDLVEVNPSINLPGVQRTVDSACALIKSAFGISDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G626</accession>
    <name>A0A2I2G626_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_456872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703605.1">
        <property type="nucleotide sequence ID" value="XM_024851655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G626"/>
    <dbReference type="STRING" id="1392250.A0A2I2G626"/>
    <dbReference type="ESTHER" id="9euro-a0a2i2g626">
        <property type="family name" value="MpaH"/>
    </dbReference>
    <dbReference type="GeneID" id="36559354"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456872"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="58"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="411" mass="46688" checksum="EB38A73C29EC5242" modified="2018-02-28" version="1">MSTDRFTITEHIPPGCHIREYPGSTVNQEDVLQLHIKQYTPKDQPQPVPADAITFIAAHGTALPKELYEPLWDELLDHSTRHGFKIRGIWVADCASMNSSGILNEDRLSMDCSWMDHSRDLFLLINHFREQMPRPLIGIGHSFGGNIITNLAYLHPRLFTTLLLLDPVIQLTPPPMGFGTDALSPINYTLWRDDVWPNREAALHANRRMLHGWDPRCARLGTSSDSSIPVTLTTTKYHDLLGQIRENFGARDPASETLRPRPCVRDPASGSIRIPRATHADLDPLAAFIPMYRPEPRSVFLRLETLRPSCLWVLGGATYLSLDEMREGIKVCGTGVTLPGLGHLMPFQEVRAVMEPCGRWIGEEMEKYRGVEREWEEKRRGRSHQVLEEQWYKTLRPLGGGQAKKARKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6J4</accession>
    <name>A0A2I2G6J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_360487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703792.1">
        <property type="nucleotide sequence ID" value="XM_024844411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6J4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6J4"/>
    <dbReference type="GeneID" id="36552111"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360487"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014175263" evidence="3">
        <location>
            <begin position="18"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="107"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="584" mass="63881" checksum="2F9126036B04257A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7V5</accession>
    <name>A0A2I2G7V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_356564</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704274.1">
        <property type="nucleotide sequence ID" value="XM_024844158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7V5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7V5"/>
    <dbReference type="GeneID" id="36551858"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356564"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="610"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB48972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="888" mass="97123" checksum="607A47A99E86C375" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G885</accession>
    <name>A0A2I2G885_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_408078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704399.1">
        <property type="nucleotide sequence ID" value="XM_024846713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G885"/>
    <dbReference type="STRING" id="1392250.A0A2I2G885"/>
    <dbReference type="GeneID" id="36554412"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408078"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="8">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="139" mass="15084" checksum="B70DACEC35FCA2B3" modified="2018-02-28" version="1">MSHDEKVASAPPLYEQQPTPIHPPTAHMVPPMEPPAWQPGMPHPSGYNTSSPLHTLQRGPAPVDCPICSHREMTRVDVESGNTTHGWAAVICCCFCLGCIPYLISSLKDVNHHCGKCGAMLATFHASGRTEVHQNVRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G890</accession>
    <name>A0A2I2G890_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">pectin lyase</fullName>
            <ecNumber evidence="12">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_383689</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704390.1">
        <property type="nucleotide sequence ID" value="XM_024845651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G890"/>
    <dbReference type="STRING" id="1392250.A0A2I2G890"/>
    <dbReference type="GeneID" id="36553350"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383689"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014121263" description="pectin lyase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="15">
        <location>
            <begin position="95"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB49088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="380" mass="39560" checksum="A9A05963EFB365F2" modified="2018-02-28" version="1">MKYTALASAAAAAFASTAAAIGVSGAAEGFAKGVTGGGSATPVYPNSIDELVSYLGDSSPRVVVLSKTFDFRGTEGTTSETGCAPWGTGSGCQLAINKDNWCNNYESSAPSVSVSYDNAGSLGITVASDKTIIGEGNKGVIMGKGLRVVSGASNIIMQNIAVTDINPQYVWGGDAITVNDADLVWIDHVTTARIGRQHIVLGTQADNRITISNSFINGESDWSATCDGYHYWGIYLDGSNDMVTMKGNYIYHTSGRSPKIQGNTILHAVNNYWHDNSGHAFEIGEGGYVLAEGNVFQNINVVAEDPINGALFTSPDAGTNAVCSSYLGRACEINGFGSSGTFSQADEDFLSNFKGKNIASAEAYGNVASSVTSNAGQGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8S6</accession>
    <name>A0A2I2G8S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_464737</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704560.1">
        <property type="nucleotide sequence ID" value="XM_024852271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8S6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8S6"/>
    <dbReference type="GeneID" id="36559969"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464737"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB49258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="26789" checksum="60E63130DE6EC600" modified="2018-02-28" version="1">MASRAPYIVPALKKHTATVIMAHGLGDSGAGWMALAQNWRRRGMFDEVAFIFPNAPMIPITVNFGLSMPGWYDIAKLGRDLDFEESLVNQDEPGILRSRDYFNTLIKEQIDQGISPSRIVLGGFSQGGAISLFTGITNKEKLGGVFGLSCYLLLSDRIKNYTPENWPNQKTPFFMGHGLDDEVVKYEFGKMSSKALTDMGLDVTFNSYPDLGHSADPEEIQDLEKFLTKTIPPQGDGETSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G952</accession>
    <name>A0A2I2G952_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_464844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704718.1">
        <property type="nucleotide sequence ID" value="XM_024852281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G952"/>
    <dbReference type="STRING" id="1392250.A0A2I2G952"/>
    <dbReference type="GeneID" id="36559979"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464844"/>
    <dbReference type="OrthoDB" id="2289918at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="9">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="442" mass="49393" checksum="38B13ED16FBA37A9" modified="2018-02-28" version="1">MSTTNTRPKRNPRRAAKDPWEEERLMTSSESPLVHLDLVKLLARPEAWEILEESEKKEILSLLPEDVHPNPHPPADDPDWKIPPLPESFLRYSNNWRDGVRQFQVDLESGRYDPEWLRQAEEASAQRAAGKFDKFKEREYEEFWGQKQKFDRSLAAGQSSQVKLQTLIEHGVVRAGDVWRYSRCFMQGSSKILLEKEVKFLSIDGPRLTFAMPFGQRVFLSNSNGHAKDSEPSAQSELSPPKPAEVETDESKKTNEEAFLDGNGAIEIESSKKRKSDAGPSGDKPPAQKRRRGQSGSTGVAKTRGDCDQEAASNTDCKNPDTAPVGIDCHPAEENPAAAAVDEAKNGDQARVETPSSANASEPGDKNRTTRPASPSICEQHDDVVVSGITGLNSLAAKIVEVDGRLKKMPRGNAWKEFRSYRNNQDMGSLWEVRQAWFLKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G979</accession>
    <name>A0A2I2G979_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosylphosphatidylinositol anchor synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_358659</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704734.1">
        <property type="nucleotide sequence ID" value="XM_024844307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G979"/>
    <dbReference type="STRING" id="1392250.A0A2I2G979"/>
    <dbReference type="GeneID" id="36552007"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358659"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000058">
        <property type="entry name" value="Phosphoethanolamine N-methyltransferase, putative (AFU_orthologue AFUA_6G04290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="850"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB49432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1071" mass="116820" checksum="7F09B30290098CDE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9G1</accession>
    <name>A0A2I2G9G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_356867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704785.1">
        <property type="nucleotide sequence ID" value="XM_024844180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9G1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9G1"/>
    <dbReference type="GeneID" id="36551880"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356867"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="244" mass="25948" checksum="05A8AC27A7A8BA9A" modified="2018-02-28" version="1">MPLTQRTATISRVTNETKIQVSLSLDGGVLPPYDASEHFPAPEDPQEAEAAKRGIVPPKDAGHATQFTATQQITVSTGIGFLDHMLHALAKHSGMSLAVRAKGDLYIDDHHTTEDTFLAVGEAFTKALGARQSLARFGRGDAPLDEALSWAVIDLSSRPWAVINIGFRREKIGDLSTEMITHGLQSFAQAAGVTLHVGCTYGDNDHHRAESAFKALAVAIRTACARRVAGEVGAGDVVSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA99</accession>
    <name>A0A2I2GA99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705101.1">
        <property type="nucleotide sequence ID" value="XM_024849330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA99"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA99"/>
    <dbReference type="GeneID" id="36557029"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437288"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="197" mass="21715" checksum="CFF09627980AA10B" modified="2018-02-28" version="1">MSPKIGLVICSQRNPRVGPQIADFVHETITQAFPTTDLSLIDLAVWNLPLCNEPGIPSQIKSPDQYTHSHTQAWSREIAAHDAFIFVTPQYNWGYPASVKNALDYLYHEWTGKPALIVSYGGHGGGKAAAQLRQVLQGLRMTPVERMVLLAFPDRDVLMKGAEGGDLGLTGEGTFWAREKEDITAAFGELQRVINNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAD4</accession>
    <name>A0A2I2GAD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_193009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705143.1">
        <property type="nucleotide sequence ID" value="XM_024842711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAD4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAD4"/>
    <dbReference type="GeneID" id="36550409"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_193009"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="16"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="488" mass="54164" checksum="A5869810D26DB761" modified="2018-02-28" version="1">MYAERCIRCPGKQLVTLPDGPDPESEDCLTINVFRPKAHTDGDEKLPVAILVPGGAFNRGAARMHNTASMLAWSAEPFVGVSFNYRIGAPGFLNAPLTDKEGLLNLGLRDQILAFEWVQENVARFGGNPDDITILGLSAAAHSIGHHIMNINQNKTLFHKAIMDSGAHTARAVHPPDASLHISHFEQFLSLTGCDKQTEDGILPCLRKQPSSTIVEASQKVFWDTDPSVRWAWQPVIDGDIISRRPIDAWKSGRWHKVPILAGFTHNEGAYFVSPSMTTSEEFTQFFATLLPQLSPDDLRTLDQLYPDPLLVADSPYLETRNMSVGYQFKRAEAAYGQYAYICPVRQTAHLGSSMTNPPIFLYHWGVNMTMLRGANHGDQMRYQTYNPEVRSISPAQDAIAGTLHAYVTSFIVSGDPNRVPGRYPDRPQWHAFVTPDEGTSGQTMVLGMGNDERAGGSHAGVVAQSVRDRFAQAECRFWWKQTENPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAY8</accession>
    <name>A0A2I2GAY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_445420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705319.1">
        <property type="nucleotide sequence ID" value="XM_024850707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAY8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAY8"/>
    <dbReference type="GeneID" id="36558406"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445420"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014172651" evidence="3">
        <location>
            <begin position="26"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="446"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB50017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="536" mass="57499" checksum="F7165AD8F316DD35" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB26</accession>
    <name>A0A2I2GB26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_135728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705390.1">
        <property type="nucleotide sequence ID" value="XM_024842439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB26"/>
    <dbReference type="GeneID" id="36550136"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_135728"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="208" mass="22822" checksum="69CDE0954899FC02" modified="2018-02-28" version="1">MCMILLRHGAQVNMKNERTGEVLLHWAIRGGHIAVTELLLANKADKSLVDLSEIRKEYPVKENDFQLCKVLLETAPNASDQLNDLSVVEADEEASRTSTPTIPPCQTTDHAAQREEVTKGSSTNSIKDMPFSELLAPPPQIVPSRVSVGSPSGDDYCCTEALTMSQAAACQYLHRQEALHPVPKVVYWSLRTSQPPVTPELDIKFGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBJ0</accession>
    <name>A0A2I2GBJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_445595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705548.1">
        <property type="nucleotide sequence ID" value="XM_024850726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBJ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBJ0"/>
    <dbReference type="GeneID" id="36558425"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445595"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="435"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="843" mass="92292" checksum="03DDD29C63FCDA32" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBX7</accession>
    <name>A0A2I2GBX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_473938</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705681.1">
        <property type="nucleotide sequence ID" value="XM_024853091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBX7"/>
    <dbReference type="GeneID" id="36560789"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473938"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="847" mass="95120" checksum="EF576908352DEFE9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBY9</accession>
    <name>A0A2I2GBY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_424775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705695.1">
        <property type="nucleotide sequence ID" value="XM_024847588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBY9"/>
    <dbReference type="GeneID" id="36555287"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424775"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014162916" evidence="2">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="210" mass="20938" checksum="C4DFA9322640CE31" modified="2018-02-28" version="1">MKLTSIAIAGLAGYAAAMPAFNFFPGPPPPDSSSLPPPPPPSETPSVVARQFPPGPPPSGTPSGPPPPPSATPSDVVFEKRQFEGLPPPPASSTPSGTPSGPSPPPSASPTFAPLQERQFEGVPPPPPSGTPSGPPPPPSSTPVVEERQFDVPPPPPSGTPSGTPPPPSATPSDAVFEKRQFEGVPPPPPSGTPSGPPPPPSASATPSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC07</accession>
    <name>A0A2I2GC07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative NADH-ubiquinone oxidoreductase 64 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_445727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705715.1">
        <property type="nucleotide sequence ID" value="XM_024850732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC07"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC07"/>
    <dbReference type="GeneID" id="36558431"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445727"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB50413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="688" mass="76993" checksum="BDA8D5342FE6A64F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCE6</accession>
    <name>A0A2I2GCE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_148167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705855.1">
        <property type="nucleotide sequence ID" value="XM_024842502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCE6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCE6"/>
    <dbReference type="GeneID" id="36550199"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_148167"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="483" mass="53163" checksum="645D8B263EE83D9A" modified="2018-02-28" version="1">MSQDSETRLSQTSLAPPAEISAPATPVHRSNLSASPEPNARAESLASRSEKSKFLSPPALSSSDMTPPPSSQVPPAPSRRSGSRSGSYLASPPDLEKTLCVAYGASENLPTAEEIGAADEPGLRTIAKELLGVAQEARMSALHFKLQNSLLSFTSNEAIKRAEVEHQLARREVEILQSSEYRSRHSETKPLQPIANVELEIALKRIQDLEGANATLDRRLRRSKKLIEQEREKSDRLVEENCLLKKRIRDNREHFSLMIENGSLSPSPQTEIQTPHRRLMPHFTDDSQHLMSRGDSSNPFAALLAADRVLNRESSNITSTPNRFRVPKHDASGHFRGSHSLSSLPMTPARSRNNRQEIQYQTPGGDSSERNRDRDSTISASDIEEAETEEDIPVSHAGALATRMFYRNNLPTNRQDGRSVGNAPKSSTLLQTKLFGQVKKSGVERSPNNLKRKASFDGAGSKKAKAEERVGLGIGTWNSNDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCI7</accession>
    <name>A0A2I2GCI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-PSP endoribonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_474152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705895.1">
        <property type="nucleotide sequence ID" value="XM_024853106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCI7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCI7"/>
    <dbReference type="GeneID" id="36560804"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474152"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="138" mass="14487" checksum="C111AAFBAB444AAD" modified="2018-02-28" version="1">MSQAARTAISTDKAPLPPPFLSQGIVVGGIVYCSGQVGVDPATGKMVEGSIQNRTRQILQNLSAVLEAGGSSIQDVVKANIFLADMGDFDAVNEVYNSFFADPKPARTCVAVKTLPLGTDVEIECSGVVTRSDRASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCP9</accession>
    <name>A0A2I2GCP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphopantothenate-cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_406010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705968.1">
        <property type="nucleotide sequence ID" value="XM_024846606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCP9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCP9"/>
    <dbReference type="GeneID" id="36554305"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406010"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="349" mass="39446" checksum="222BDA937E18AA9D" modified="2018-02-28" version="1">MSPSFAEKMARAEVEADFFGQQPPPDSLAEHETLVRNFIDYHRETSRRVALVTSGGTTVPIEAQTVRFLDNFSGGTRGARSAEYFLQRGYAVIFLHRQNSLLPYDRHYSNSKNCLLDLLDVVQGASGDSGSDGHRITVRREHEDQLCHVLQQYRSARENNLLLLLPFETVTDYLFHLRSVTILMWPLRATGLVYLAAAVSDFFIPHSEMAEHKIQSSVPSSHPRKDGVDLSCVKSENLSLDLKPVPKFLKSLVDDWAPVGSMIISFKLETDSNILLDKAHGSLQRYGQHLVIGNLLSTRQSEVVFVEPDQPRERWIRVPSDEDGLKMEIESLIVDEVAKMHSEMIGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDB7</accession>
    <name>A0A2I2GDB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_474445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706198.1">
        <property type="nucleotide sequence ID" value="XM_024853141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDB7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDB7"/>
    <dbReference type="GeneID" id="36560839"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474445"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="256" mass="27402" checksum="C2445EA46441787E" modified="2018-02-28" version="1">MGSLSYRDAISILQLIAFLPSFFVAAFLVFRHGIRTSGGFIFLVIFSIARIVGACCELATIKNPSTGLYTAAAICSSIGLSPLLMTCSGLLSRANLSMLPAPISRLAFSLFRIVTIVALALTISGLTGHMTVEGMEHPNTTVKVGMVLYVVSWVALCAILGVLFVCRSSFAQGEKRALLAVAISAPLLLVRIIYAMLVFFLANSTFNALNGNNTAQLFMSVLVEIGVVVVCLVIGFTLKVRKPSQDFKSIPVREMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDQ9</accession>
    <name>A0A2I2GDQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_406565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706348.1">
        <property type="nucleotide sequence ID" value="XM_024846637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDQ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDQ9"/>
    <dbReference type="GeneID" id="36554336"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406565"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="514" mass="56340" checksum="8625C4B2491BB591" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDZ4</accession>
    <name>A0A2I2GDZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_455329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706339.1">
        <property type="nucleotide sequence ID" value="XM_024851517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDZ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDZ4"/>
    <dbReference type="GeneID" id="36559216"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455329"/>
    <dbReference type="OrthoDB" id="5320223at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="136" mass="14882" checksum="3EBFDDE1DA98D4F4" modified="2018-02-28" version="1">MPLSGHCLCKAVTYTVDVDQPLITAYDHCDDCQRQSGSTYSLVTVVPKEKLTINGPTKKYSSKGSSGFDVHRIFCSECGSPIAHDPDAAPEIIALKAGTLDTELKKNLKPDTEIWTVSKLPFCQEHLAKPFANMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE76</accession>
    <name>A0A2I2GE76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_436254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706472.1">
        <property type="nucleotide sequence ID" value="XM_024849119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE76"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE76"/>
    <dbReference type="GeneID" id="36556818"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436254"/>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="341" mass="38516" checksum="19F8FFF389EE5D8F" modified="2018-02-28" version="1">MAEQMEEGRANPVPSEPPPLPYSLRTRKKSIAIFWSLFVLDLAAQPVALYWGLWYGTDLSHNMVFTIVTITLGGISVFEYFFRLYNLFRKDSRTRPLNAKKSWLDFFHINFTIVWLILAVELITGTVVEEPYVRLVAMVLPSVMFYFGAVYLALDILRVCGFKAPFRISSTPKGSVMPTALYVLIEDVVAVDGGGGQIYRYALRTRYLSSPYFRRMLFQMNCFWAGGSIVFAAAFTAIIFTTPQSVAFTLGWTLPLVWAGVWTLITIPWVQSDLRREKKAWQEHRVQGGVPTYTDEVGAPSARTRLESVQVNLPSFLPWVRSPEKAKVSSPPTPSDGQSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF02</accession>
    <name>A0A2I2GF02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_453185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706766.1">
        <property type="nucleotide sequence ID" value="XM_024851340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF02"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF02"/>
    <dbReference type="GeneID" id="36559039"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453185"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="703" mass="79895" checksum="7ED310B8062B15DA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF59</accession>
    <name>A0A2I2GF59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_376043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706822.1">
        <property type="nucleotide sequence ID" value="XM_024845344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF59"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF59"/>
    <dbReference type="GeneID" id="36553044"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_376043"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000037">
        <property type="entry name" value="Similar to acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF34">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="158"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="265"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="441" mass="49727" checksum="B0C235743FC02EE7" modified="2018-02-28" version="1">MNFDLPPDVTRFLESLDSFINAEILPLQHADDNDRFFDHRREFARTDWGNGGLPKPEWEDLLTKARTLADKAGFYRFALPSIYGGQSHPQTNLCMAAIRYYLASHPTYGGGLGLANDLQNEHSVVGNFPDILMIHHFGSEEQRRLIPLRLEGKFRATFGLTEPGHGSDATFMETVARRVPGGFEISGSKKWQTGAHACTHFIIFARTSGKEGSGRGITAFLVPRETQGVRVVSYEWTMNMPTDHATVVLDGAFVAEEAVLGAVDEGLAIAQTFVHENRLRQAASSCGAARFCLDRSVERAKSRRIWGGKSLSENQAIQFPVVELATQVEMLRLLILKTGVDMDRVAGEAEREGKRPWVEIERQLSHQVAMCNFWANRLVCQAADRAIQIHGGDGYSRHYPFEHIYRHFRRYRITEGSEEIQVRKIAGFLFGFRESDRQQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFW7</accession>
    <name>A0A2I2GFW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative forkhead transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_87669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707087.1">
        <property type="nucleotide sequence ID" value="XM_024855422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFW7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFW7"/>
    <dbReference type="GeneID" id="36563129"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_87669"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="207"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="207"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="706" mass="76460" checksum="DB1A04DEE8B03224" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG20</accession>
    <name>A0A2I2GG20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_89763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707138.1">
        <property type="nucleotide sequence ID" value="XM_024855428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG20"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG20"/>
    <dbReference type="GeneID" id="36563135"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_89763"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="554" mass="62658" checksum="1CC816B2E88858FA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG58</accession>
    <name>A0A2I2GG58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_91991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707168.1">
        <property type="nucleotide sequence ID" value="XM_024855432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG58"/>
    <dbReference type="GeneID" id="36563139"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_91991"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="153" mass="17178" checksum="4046A817D8004491" modified="2018-02-28" version="1">MDPPPPTSRRVFQMEKCLTNHPRFSVSIRSAQIARITVNLDLEVIVGRPSCFSFLFASAALAAEGIFLPTIVRVPKILFFLSFSCHHLGVFVLHLVSESPTLPIPFLPRLDYLALITLDRDLLGAVKLRRQLKPGTRRCRVRKGSWRLSLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGJ3</accession>
    <name>A0A2I2GGJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_95310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707310.1">
        <property type="nucleotide sequence ID" value="XM_024855451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGJ3"/>
    <dbReference type="GeneID" id="36563158"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_95310"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="163" mass="18240" checksum="7792A786588A4B81" modified="2018-02-28" version="1">MKSWSSSLSLKRYMSRPLSPLGQYSPTTVRFGAKALGTFRLGVKYGVVIDQRALQTVPLSSVAHLRWTLHDESILDTDRYHVMKMPYLKSHPSLVNTLASALTTYGILNVIRPHSSLKIYCTIARANLYHKPPYSFRRRAHSSTTWATPAAIGTIPSVGRPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGZ2</accession>
    <name>A0A2I2GGZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_98126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707458.1">
        <property type="nucleotide sequence ID" value="XM_024855460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGZ2"/>
    <dbReference type="GeneID" id="36563167"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_98126"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="155" mass="17663" checksum="8BAF0C50AA505159" modified="2018-02-28" version="1">MEKKWADVGQARERKREKSGRGKKVGECKKERRGQRENKKKKKRKNHHIPRTYEGSQEWTCAVVYWSVVLPPTCLPYSVRSTSCIKASPLLLGVSKMTNLINPSWLVTSNTYLAPGGQSGDSRATWPFAWLRIARMTTIANTTTNTTADQRVQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH33</accession>
    <name>A0A2I2GH33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_98517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707490.1">
        <property type="nucleotide sequence ID" value="XM_024855462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH33"/>
    <dbReference type="GeneID" id="36563169"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_98517"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="151" mass="16605" checksum="3AF6F3BDF071E88A" modified="2018-02-28" version="1">MMFCAQSHGGRSRLVGQETKTPRIARTGRCQGLTIVGNDRLDWCRWIPPIEEWTNRFFSQVATEGISNSSTASVVCAVPRTHVIPLLPLLSLSLSLSLPLRVAESTPPFVFNSTITTLLPTSIIRAEADPMAPCNTFKSKSKKRQPVGPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHL9</accession>
    <name>A0A2I2GHL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_453778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707683.1">
        <property type="nucleotide sequence ID" value="XM_024851388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHL9"/>
    <dbReference type="GeneID" id="36559087"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453778"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="144" mass="16395" checksum="532E2E9EB088810E" modified="2018-02-28" version="1">MSSIAAMASRRAFARQSLFRAPARRAYSSKVEEAGLDKAPRRDPELYVLLGVMSGAFLIAGWYFGKKPTSVTSESNVRIPDSSMPWEREDDGKVYKYQYHPHGDKNQPLRNAPSALNTVIVPNVTLPEDLHERFNKYGKEEWDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI87</accession>
    <name>A0A2I2GI87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_507320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707859.1">
        <property type="nucleotide sequence ID" value="XM_024854475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI87"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI87"/>
    <dbReference type="GeneID" id="36562181"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507320"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="25252" checksum="BA6A9E79C61320D7" modified="2018-02-28" version="1">MLPAPDPHRALFIPEILEAILLQLVGEYRIGRKYFYGEHTILLSQRVCRYWNDVIKSSSEIQTALYFKPKSFKSDDPDPSHESSQMIQSIIWHQIYKYYYLNMPHKESKARDNTPVLDKRQDAFMRKEASWRRMLVHQPPCPNVMRFLKELVLGASAFSEAKFDGADEFLRLGNFVTVILEGKITLGVWDLLIYADIKVLYRLYKCGSLIWKAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GII5</accession>
    <name>A0A2I2GII5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial phosphate carrier protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_434418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707998.1">
        <property type="nucleotide sequence ID" value="XM_024848709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GII5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GII5"/>
    <dbReference type="GeneID" id="36556408"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434418"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="175"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="276"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB52696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="376" mass="40959" checksum="F9EA92DCC3FAA58D" modified="2018-02-28" version="1">MLPSENVVASAFSHPLRRAEEHSAVPAPKRRNPFPAWSVIDDTKKSAGSLTKEATREFNAASEKVQAKTGHIEPWTPKYYAACTVGGLLACGVTHTAVTPLDLIKCRRQVDSSLYKSNGEAFRKIRGAEGLRGVFTGWSPTLFGYSAQGAFKYGGYEYFKKFYSDLVGAENANRWKTSVYLAASASAELIADVALCPFEAVKVRTQTTIPPEFRSTFSGISSIVSKEGVAGLYKGLYPLWGRQIPYTMMKFASFETIVEMIYHYLPGQKSDYNKGAQTGVAFTGGYLAGILCAAISHPADVMVSKLNANRQAGEAFGAATSRIYKDIGFRGLWNGLPVRIVMIGTLTGLQWMIYDSFKIFMGLPTTGGGPAPEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIN0</accession>
    <name>A0A2I2GIN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_378804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708036.1">
        <property type="nucleotide sequence ID" value="XM_024845463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIN0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIN0"/>
    <dbReference type="GeneID" id="36553162"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378804"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="114"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="362" mass="38790" checksum="0C1D0BD171A0C9DE" modified="2018-02-28" version="1">MESVSHEDPSSTSSSRSTSRTRQKSSQSNQSAASYFSYPVTHVVSGLYRRLTDPPSKANAMGRSQRDSKSSLTSPNDSSSSSRVFTPVRTVSPFQPPPLTPLTLTGDPSNLQQQLLTRALAEEIRLLVPARLQLVDTWRLAYSLDRDGASLATLYENCREISNRSPRAGYVLIVRDSSPAGAVFGAYMTDPPHPNPHYFGTGECFLWRASILPPPGNLSLAAGGPPSEDLLEMAGLPPPPSADTTHAGRSTTLRGDKKGAASGQAEEHRLAPPLSNGGASGASTPDRIRFKAFPYSGVNDYMMFCETGFLSLGGGDGRYGLWVDSSFEKGVSSSCQTFGNEPLSDEGDKFDVIGVEVWYVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJM2</accession>
    <name>A0A2I2GJM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_123092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708385.1">
        <property type="nucleotide sequence ID" value="XM_024842367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJM2"/>
    <dbReference type="GeneID" id="36550062"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_123092"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="116" mass="13263" checksum="60D4BE29ACE6AE80" modified="2018-02-28" version="1">MISQSTRLSVRLQSPRAVLFLRPFLEYTIDVSSESWFGGKVSFLFFSFPFLFYHVLQFMIPPFPSIVDCGSSIRCLSHGRVIPAELSQPSRGSSFGLWYGDWILTNGDFSFFFLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJR7</accession>
    <name>A0A2I2GJR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_123736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708428.1">
        <property type="nucleotide sequence ID" value="XM_024842374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJR7"/>
    <dbReference type="GeneID" id="36550069"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_123736"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="133" mass="15850" checksum="D947922A5E66F494" modified="2018-02-28" version="1">MIPFSITGSEFQAFVILWTIDLCAWRQFSDFLSNSSSSFFFFSPSLQHPRTFCQAPFFFSFILFLLRSHYVAFPIPAYEHDIKLLELYLQITERFFIPSMFISFLPFFFLSSLSIFLYSSFSFRIFFSLVDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJX8</accession>
    <name>A0A2I2GJX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_353003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708474.1">
        <property type="nucleotide sequence ID" value="XM_024843952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJX8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJX8"/>
    <dbReference type="GeneID" id="36551652"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_353003"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF11">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="501" mass="53524" checksum="3014D60078A522C8" modified="2018-02-28" version="1">MSSLQLNDNSLFITKNYVDGEWLESSSGATFPVTNPANNAVIARCPESTAEDVQHAIKAAENALPAWKAKSGRERSRILRQWYDLVLQNEDDLAALITLENGKAASEAHGEVLFTASFLEWFSEEAARVYGDIIPATSPGNRISVVREPIGVCGMITPWNYPAGMITRKAGAALAAGCTTVIKTDGRTPLTGYALAILAERAGVPHGVINIITALENTPIIGQTMCKSNTIRKISFTGSTRVGKILMEQSGSSLQKLSLELGGNAPVIIFDDSNLELAVEGVLTSKFKSTGQTCVCANRIYVQDGIYDKFVARLVQRVLRFKVGSGSDNSVTHGPLIEASAVAKSREHVDDAVSKGAKVLAGGKEFRTDADPKGPNFFDPTILADCNASMKLAHEETFGPVAALFRFSSEDEVIRAANDTDVGLASYVFTSDISRVHRVSDALHVGMVAINTGVMSDAPAPFGGVKHSGLGREGSKYGVEEYTELKTIMMGNVYGAGRANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL69</accession>
    <name>A0A2I2GL69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pathway-specific regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_504539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708899.1">
        <property type="nucleotide sequence ID" value="XM_024854208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL69"/>
    <dbReference type="GeneID" id="36561914"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504539"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="160"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="642" mass="72753" checksum="D76D209100C910FA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM31</accession>
    <name>A0A2I2GM31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_345307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709244.1">
        <property type="nucleotide sequence ID" value="XM_024843506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM31"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM31"/>
    <dbReference type="GeneID" id="36551206"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_345307"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000186">
        <property type="entry name" value="Putative Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="13">
        <location>
            <begin position="18"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="744"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="695"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB53942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="793" mass="88482" checksum="63CDBB2AF0C5306A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM49</accession>
    <name>A0A2I2GM49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_372527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709232.1">
        <property type="nucleotide sequence ID" value="XM_024845202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM49"/>
    <dbReference type="GeneID" id="36552902"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_372527"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11028" checksum="643191DE3EAA47A9" modified="2018-02-28" version="1" fragment="single">MRQVQSTSIEDECHEAVLDFIQNLSADESELFEATEKSQQLIDDLRHVDSCQKGSISRKIAPNITKFVAGIEQYGTAMDVLAGSVSLMSPIWASVRVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMI6</accession>
    <name>A0A2I2GMI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pectate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_420863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709389.1">
        <property type="nucleotide sequence ID" value="XM_024847328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMI6"/>
    <dbReference type="GeneID" id="36555027"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_420863"/>
    <dbReference type="OrthoDB" id="4412891at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014160033" description="Pectate lyase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12737" checksum="DFB0CBA09D520506" modified="2018-02-28" version="1">MKCLLLIFLGFLTGSHAAAIGEFENSTKTFDPEHPEEIVAGDYVFSKKGTPITLPIQSDRSNRLPRGCMNVTRIGDGATVASRSIASARRALAVGPATVVLIVVSRVLASLLWHAFDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMM4</accession>
    <name>A0A2I2GMM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709416.1">
        <property type="nucleotide sequence ID" value="XM_024848117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMM4"/>
    <dbReference type="GeneID" id="36555816"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431775"/>
    <dbReference type="OrthoDB" id="10321977at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014112905" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="125" mass="14313" checksum="C6926A41ACF1B019" modified="2018-02-28" version="1">MRSVSFLIVLLLARLSSAQYEGVLDVNDPSCPRRHGPHLHFEWTFDRTQGRHNCFEIELPQNHYFLSMKARREGPILGAPDMFGICEKNCKNCTQLWKVAADETSDNVHVPCTETSGTKYIYIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMS7</accession>
    <name>A0A2I2GMS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_504971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709485.1">
        <property type="nucleotide sequence ID" value="XM_024854255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMS7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMS7"/>
    <dbReference type="GeneID" id="36561961"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_504971"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014136521" evidence="3">
        <location>
            <begin position="20"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="399"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB54183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="521" mass="56612" checksum="D22A2D2C48EC6542" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNG8</accession>
    <name>A0A2I2GNG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acyl-CoA thioester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_347466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709726.1">
        <property type="nucleotide sequence ID" value="XM_024843634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNG8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNG8"/>
    <dbReference type="GeneID" id="36551334"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347466"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="99"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="296"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="462" mass="51093" checksum="48F0C609344ED44E" modified="2018-02-28" version="1">MLGPTTRRSAVTPAKCLAAARNVTVRRTPGASWIASKDFHSSPAKAAFRPTWMPMRVKTPWIEALTKSRENAQSGQASSTPLAKPDLTPKKMSDSFYSAILPLAQDKWLLDSYLNASGHIRLGSLLMDLDALAGVIAYRHTGDSVTTVTAAVDRITIEHPLMEICDLELSGQVTYATGRSSMEVSLQVAKVPAQGQQAKPEDVLITCAFTMVSLDPATKTPVSVAPLVIESAEERLLFKQGEENYQAKKSLRTKSLLQKAPGDEESDLIHSMWTKEMSYLNPESPAQRPSNMIFMSDSVLKSAMIMQPQDRNRHNFMIFGGFLLKQTFELAFCCAASFSHARPNFISLDPSTFENPVPVGSVLYLRATIAYTEPLERDGSKFTKVQVRVDSKVRDVEHGTKKSTGQFNYTFLVEKDIQVMPKSYGEFMLWTDARRRAQNAAAMTHGSKEPSALRSIKDSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNI4</accession>
    <name>A0A2I2GNI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_432078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709739.1">
        <property type="nucleotide sequence ID" value="XM_024848184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNI4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNI4"/>
    <dbReference type="GeneID" id="36555883"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432078"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="434" mass="47742" checksum="37417E85F87765FF" modified="2018-02-28" version="1">MDFSRSPGGFRSRRSYPSLNHISLAPLTPRFPIDDDEDDLSPGAGGDYFSARNPHHDEDKSAFSPRISYLSSYSVPGTPGVLSHSHSRSGSRVRHHQRSKSSGRMNLSDTNLQGQGVAAGQPLHHQQHQHQHQHQRHHVGDDLSKHRNSSSVKQGYPSESTGRRDTEWMLRAGIALASSTREEKGQSWLAKRESSTSLVSEGVYDGNSAAGLHGRSNRRTKSGRSTPLAHSRHGSRAVSRRNSRPDLAMTSLDMGSAVAGGSSHTPIHGASPADEGRHLVPDFVDERIRAEMESIRQEAEEYSTSESDKSWDSEDEMDEQELQRLTRERGFGLGSWIDRMVEWTLFGVEDWPLLSSSDPDPAERPTKHVEITTEEPLTIGDHSGDTLGPGSVDNDDGVSVASEIEVGTVGEKPGELGGWEDAGWLFRTVKRLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNY2</accession>
    <name>A0A2I2GNY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_343458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709884.1">
        <property type="nucleotide sequence ID" value="XM_024843403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNY2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNY2"/>
    <dbReference type="GeneID" id="36551103"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_343458"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014182489" evidence="5">
        <location>
            <begin position="20"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="602"/>
            <end position="603"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="621" mass="66822" checksum="B139389BE6B6139D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPC7</accession>
    <name>A0A2I2GPC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_442766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710028.1">
        <property type="nucleotide sequence ID" value="XM_024850482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPC7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPC7"/>
    <dbReference type="GeneID" id="36558181"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442766"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="47839" checksum="0F7D14FE4E11EFBA" modified="2018-02-28" version="1">MSYSIIYNLFLSPLAPYPGPKLWAISNIPYLISITRGRSHIKILELHSQYGPALRVGPRELSFNSPQAFQDIYASRPGQPQFPKDPKFYASKLNRIDECVAGNLDDEAHTRQRRLLSREATIVYFVSLLVQRLRGQIKDEKHGAKVDMKAWFNFTTFDITGQIMFSEPFDCLQNSHLHPWIALIFDSVKGMTVLSAMNRFSMFRQLLEAVFPESLRRKMLRHFDYSSQKADRRLEKGSDHEDFMAVVSTHGVHEPGAKAIAGQLTMTRAELYANSSFISIAGSETTASLLCGCVYYLCKNRDCLDRLCREVRTEFSTDDQIVSPQCNRLTYLNAVIEESLRLYPPAAAGLPRLVPKEGAIVNGRFLPQDAFVFISSRIAIYPRSNNLQITVSGHQYATNHSAANFKLPEQFIPERWLGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPF9</accession>
    <name>A0A2I2GPF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_432355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710062.1">
        <property type="nucleotide sequence ID" value="XM_024848245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPF9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPF9"/>
    <dbReference type="GeneID" id="36555944"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432355"/>
    <dbReference type="OrthoDB" id="4368991at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014189316" evidence="2">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="183" mass="19038" checksum="5A2B89C7C7FD2644" modified="2018-02-28" version="1">MTLLKPLLLASILSISASATEYNCPTGWLPNQFKQERCCPGGMVVDEQGAYCCVQDMRFYKEALTNSALLYETATTTSDSNMDWTTEKDINSCYATVRFTASDYSARVSSALSKAEATPTDGSSSEATATASSSTRSGARSTAGSQTATATATATETSNAAVLIGPAEGLLGGVVFAVGAFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPX6</accession>
    <name>A0A2I2GPX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_421562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710229.1">
        <property type="nucleotide sequence ID" value="XM_024847372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPX6"/>
    <dbReference type="GeneID" id="36555071"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421562"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="205" mass="21879" checksum="47BA6FAD8F5CFCB1" modified="2018-02-28" version="1">MPENREPPATVAAAATVEGPTSKKDFKLATGQSRALEGSGGGLGGHARWSRNATTDGNDWMAVLCHVPVVVGSLNTIHDERNLVQPLGLFILLTESVCHPPFDGSTAPLPQVGCFRIISAATKQDRHIGLSTACGPGEHLQFCRKRSGSTPVLRIGLNPLPAMRNPFPSPQPVDDVQVLHMEDKVGGGPEGFGWNLEGPRRSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPX7</accession>
    <name>A0A2I2GPX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_442883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710224.1">
        <property type="nucleotide sequence ID" value="XM_024850493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPX7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPX7"/>
    <dbReference type="GeneID" id="36558192"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442883"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF19">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="593" mass="65131" checksum="4CD92F91E9A06A2F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ93</accession>
    <name>A0A2I2GQ93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative kynurenine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_470462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710336.1">
        <property type="nucleotide sequence ID" value="XM_024852757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ93"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ93"/>
    <dbReference type="GeneID" id="36560455"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470462"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="40"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="429" mass="48102" checksum="20F3D4664DC01072" modified="2018-02-28" version="1">MSATAARPDPFKPARRVAGQRQDVWSIVNEAAAASPVQPIVNMGQGFFGYNPPKFAIDAAKDALDRVECNQYSPTKGRPRLKKALADAYSPFFGRTINPDTEVSITTGANEGMLSAFMGFIEPGDEVIIFEPFFDQYISNIEMPGGTIRYVPLHPPKDGATRTSPASEWTIDFEELENTINPKTKMIVLNSPHNPVGKVFSRAELERIGDLCIKHNLIILSDEVYDRLFYVPFTRIGTLSPELYERTLTVGSAGKAFYATGWRVGYLIGPEHLIKYVAGAHTRICYSSVSPLQEAAAVAFEQADKVGFWDESRTEMKNKMERFCQVFDELKIPYSDPEGGYFVLANMSSVKLPENYPFPPHVANRPRDFKLCWFLIHEVGVAAIPPTEFYTDANAHIAEDYLRFAVCKNDDVLETAKERLRGLKKYIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQZ6</accession>
    <name>A0A2I2GQZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_374962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-glutaryl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-glutaryl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87828"/>
            <dbReference type="ChEBI" id="CHEBI:87829"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-malonyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-malonyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11878"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87831"/>
            <dbReference type="ChEBI" id="CHEBI:87833"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-succinyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-73 and Arg-76) that bind to malonylated and succinylated substrates and define the specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710607.1">
        <property type="nucleotide sequence ID" value="XM_024845303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQZ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQZ6"/>
    <dbReference type="GeneID" id="36553003"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_374962"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061697">
        <property type="term" value="F:protein-glutaryllysine deglutarylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="256"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="282"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB55305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="319" mass="34755" checksum="B2F57DCB1D2E7830" modified="2018-02-28" version="1">MASSAIPAADLRSFTEYFKGCKRVLALLGAGISASSGLPTFRGAGGLWRSHDATDLATPEAFEANPDLVWQFYSYRRHMALKAKPNPAHFALAELARKNKDFITLTQNVDGLSQRANHPLQQLHLLHGSLFTVKCTSFYCNYSRENDFTDPIVPALEIPKGNPEFISSTEDKTGESASKSMSDYLGNAEAPEADISDERVPLPALSLDVLPQCPACKDGILRPGVVWFGESLPMHTLDMVDSWMRSGPIDLILVVGTSSQVYPAAGYVDKARDRGARVAVVNMDRNDIGASGLKQGDWFFQGDAGTIVPEMLKDFIGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRF7</accession>
    <name>A0A2I2GRF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710767.1">
        <property type="nucleotide sequence ID" value="XM_024848387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRF7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRF7"/>
    <dbReference type="GeneID" id="36556086"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433003"/>
    <dbReference type="OrthoDB" id="4511154at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014172662" evidence="2">
        <location>
            <begin position="19"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="179"/>
            <end position="188"/>
        </location>
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            <end position="222"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <end position="268"/>
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    </feature>
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            <end position="288"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <end position="307"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <end position="357"/>
        </location>
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            <end position="384"/>
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            <end position="466"/>
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        <location>
            <begin position="514"/>
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        <location>
            <begin position="672"/>
            <end position="683"/>
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        <location>
            <begin position="684"/>
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        </location>
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        <location>
            <begin position="727"/>
            <end position="743"/>
        </location>
    </feature>
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        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="822" mass="77861" checksum="86DBE29E63216FCA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRT8</accession>
    <name>A0A2I2GRT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_346381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024843566.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1392250.A0A2I2GRT8"/>
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    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF5">
        <property type="entry name" value="BYS1 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G04533)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="135" mass="14866" checksum="0458DA9B784B5D31" modified="2018-02-28" version="1">MTNQTLGHAVVVNECARPIYVWSVASSVSSEITLQPHENYTEVFRHDSQTGGVSIKVTTLKDGLYHSSPQTVFAYNLVNQSVWYDLSDVFGDPFHGSKVTLLPSEPAITWEEGIPPAGSQVRIQDSSRDLVLTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS16</accession>
    <name>A0A2I2GS16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710971.1">
        <property type="nucleotide sequence ID" value="XM_024852807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS16"/>
    <dbReference type="GeneID" id="36560505"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471078"/>
    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26393" checksum="BECA32F3494DFB13" modified="2018-02-28" version="1">MAHNSHNYGWQGRTSQPFHPPSMAMDQQSFSQPPISSVPGYHVGYNQPPPSTQSYYQPGIPATQYLSSHPSMPQSRHHARSSPAPYSYPSSQVSSSPPTIQDPAFTSPPSSYLLNQPDYYLAQNSSFPSNPSSLGVNPPAQNLINPGTVYSSAESTPNAGSSDPEQQVRVISFRPKPQCWDHGCNGREFSTFSNLLRHQREKSGVVAKAECPSCGAVFTRTTARNIHVAQGKCKGGGRETSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSA8</accession>
    <name>A0A2I2GSA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_49759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711076.1">
        <property type="nucleotide sequence ID" value="XM_024854115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSA8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSA8"/>
    <dbReference type="GeneID" id="36561820"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_49759"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="699" mass="74597" checksum="7D4317E7398A82EA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQ73</accession>
    <name>A0A2I2FQ73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000032">
        <property type="protein sequence ID" value="PLB42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698058.1">
        <property type="nucleotide sequence ID" value="XM_024848033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQ73"/>
    <dbReference type="STRING" id="1392250.A0A2I2FQ73"/>
    <dbReference type="GeneID" id="36555732"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431421"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="224" mass="23458" checksum="A5D78F0613B6FF2E" modified="2018-02-28" version="1">MALTRRPYLPASVFPPIPPGSPPRANWSGGGPPQVHSTRHQTTPGPFAPGTGPPPCLFGPAPTHPPDLLPQAPDRPRAFSVRRPPTPGPFAPGTGPPPCLLPRAPHPPDRFASRPRPLASRDHSHPASQGTLPRQLVRQWAFVPYLAPTRQAPSTSLYSPQAPSAPTGLAVGHPRSIRPGTRPPPDRPRAFSVRRPPAPDLLPQAPCPPGGAPPSPATPAPGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FR60</accession>
    <name>A0A2I2FR60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_71614</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698403.1">
        <property type="nucleotide sequence ID" value="XM_024855347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FR60"/>
    <dbReference type="STRING" id="1392250.A0A2I2FR60"/>
    <dbReference type="GeneID" id="36563053"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_71614"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="113"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="333"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="624"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB43101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="962" mass="108008" checksum="779205A4710DCAFF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRG9</accession>
    <name>A0A2I2FRG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_431190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698536.1">
        <property type="nucleotide sequence ID" value="XM_024848009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRG9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRG9"/>
    <dbReference type="GeneID" id="36555708"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431190"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001035">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000868">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="240"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="710"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="823"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="538"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="987"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1068"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB43234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120203" checksum="1CCEBC57D74A7A2E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS62</accession>
    <name>A0A2I2FS62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_451446</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698748.1">
        <property type="nucleotide sequence ID" value="XM_024851187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS62"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS62"/>
    <dbReference type="GeneID" id="36558886"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451446"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB43446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="447" mass="49825" checksum="A1ADB5CB6246CB14" modified="2018-02-28" version="1">MREIIHLQTGQCGNQVGSAFWQSISGEHGLDGSGVYHGDSDLQLERMNVYYNEAGNMKFVPRAVLVDLEPGTMDAIRSSSFGALFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVVDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVEHADETFCIDNEALYDICMRTLKLSSPAYGDLNHLISTVMSGITVSLRFPGQLNSDLRKLAVNMIPFPRLHFFMVGFAPLTSRGASSFRAVTVPQLTQQMFDTKNMMTACDFHNGRFLTCSALFRGKVSMKEVEDQMRNVQSRNSAYFVEWIPNNVQTALCSVPPRGLKMSSTFVGNSTSIQELFQRVGTQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLMSEYQQYQDASISEGEDNYVEEQAFEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSC6</accession>
    <name>A0A2I2FSC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative 4-coumarate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_450779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698847.1">
        <property type="nucleotide sequence ID" value="XM_024851144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSC6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSC6"/>
    <dbReference type="GeneID" id="36558843"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450779"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="39"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="464"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="562" mass="62860" checksum="E865949E86EBA0D8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSC9</accession>
    <name>A0A2I2FSC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide binding protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_369242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698842.1">
        <property type="nucleotide sequence ID" value="XM_024844898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSC9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSC9"/>
    <dbReference type="GeneID" id="36552598"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369242"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
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    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="353" mass="40733" checksum="9B1A9FFFF18299C9" modified="2018-02-28" version="1">MGCGMSTEDKEGKARNEEIENQLKRDKMLQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFKEIIYSNTVQSMRVILEAMESLELPLEDARHEYHVQTVFMQPAQIEGDSLPPEVGSAIGALWRDTGVQECFKRSREYQLNDSAKYYFDAIDRIAQPDYLPTDQDVLRSRVKTTGITETTFLIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGADYAAACDYILNRFVSLNQAEQKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRLCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSH2</accession>
    <name>A0A2I2FSH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_441019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698858.1">
        <property type="nucleotide sequence ID" value="XM_024850213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSH2"/>
    <dbReference type="GeneID" id="36557912"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441019"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43556" checksum="D8DC1A8DD757A7B9" modified="2018-02-28" version="1">MAQDVDHSLLQSPGSQPSLDNRPSEIPSPAKWTSGPSTLAPNGQYGDRQPLEPFPNGTMDQVSTMSYIPEESEMENGVVSPPQQKKSRTLPAWIRSVEDLEDEPEATATSRLLPANPDEAVVAQHNHSPHATRRPDPPYADRGSLEDGRAISPRRESRWKNFSKEIAYPREPGVEEKAVTPEWLNENHGDYSQPWRGQRASWECEDTEDPLRKKRRREIWFKRFHNTLLKSPIVPLIFRLTVWCFSLTALALGGSIQHLSQEYVHPQGPSALMAIIVDAVALVYLIYITWDEYTSKPLGLRSPSAKARLVLLDIFFIVFDSANLSLAFESLSTISGACTVGEINQEITPKNDRICDRQIALASVLLIALLAWLTTFAISVLRLVERAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSN7</accession>
    <name>A0A2I2FSN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_417907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698960.1">
        <property type="nucleotide sequence ID" value="XM_024847185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSN7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSN7"/>
    <dbReference type="GeneID" id="36554884"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_417907"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="365"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="598" mass="67594" checksum="798C280C48E8040E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUG6</accession>
    <name>A0A2I2FUG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_513479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699566.1">
        <property type="nucleotide sequence ID" value="XM_024855115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUG6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUG6"/>
    <dbReference type="GeneID" id="36562821"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513479"/>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB44264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40984" checksum="872691459FECF34E" modified="2018-02-28" version="1">MASTNTEASPTPPATAFLPFFRTLPPLLPIHSWVSGPSAMNNDPGVQFVAARPRKRDHREMSQSHGRPPWRPEAEASSSSAHPRPSSSPPRPRYAGDGLDFRRPAPSASQDSIIDLTNEPDSPPQTFHSRLPARHSQIRRPRPPRFGRDIMAEVVDLEEEPEPSGSGQADAPSSPEVQFISASVRPPPSREPTFETNLLHMLRFHDPMIHGVPNRDVFRDEVARRARRMARHPPLDVDTVWVGGSGGAIDLTNFPLDMDYVLQSLTTPDRGPPPNAYKPPSPAPEGFTRTAGEDEVVCCPNCDAELGTGDETKQQIWVAKQCGHVYCGECATHRSKSSAKKAATQRVKPFSKCQVSDCAKSVSAPRAMFQIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUH2</accession>
    <name>A0A2I2FUH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PalH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_392452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699600.1">
        <property type="nucleotide sequence ID" value="XM_024845976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUH2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUH2"/>
    <dbReference type="GeneID" id="36553675"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392452"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="794" mass="87483" checksum="8E25950DBF516715" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV54</accession>
    <name>A0A2I2FV54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_430385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699804.1">
        <property type="nucleotide sequence ID" value="XM_024847951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV54"/>
    <dbReference type="GeneID" id="36555650"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430385"/>
    <dbReference type="OrthoDB" id="4507091at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="3">
        <location>
            <begin position="41"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="369" mass="40732" checksum="1B0A2AD6153064D0" modified="2018-02-28" version="1">MGSPPATKNVASPEKGKERADEKVHLEPEGPARSLKEAGKHILVVGPKGSGKTAGIQLATNMEIQPENTGNTDTNNVRTYSTVIDGQALTFIDTPGFSELDTNNNDTAIQICQWLCDNIFAHEKDIHGILCLQDIGMLKSIRAMDCTAEFLHAIIGGNNARNTAFVTTKWDALNQSKLSQFDAKHDDWGRTALWRQMLNSGAILFRHYGISNTADDSEDDIRRAQQSIRDLLSHFNTSHPVSLQLREEFGGQRDRESTAKWLVNAMPSLHQFNQREANIRNNNTQGDLSQDQAPEGYSKKTKVAAGVGAAVAGAVGYYYRDDIKRGAKTVAKEVSRKHRNVERNTGMDWVFYPWITPDGIGIGGRGALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVE4</accession>
    <name>A0A2I2FVE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_459117</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699920.1">
        <property type="nucleotide sequence ID" value="XM_024851844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVE4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVE4"/>
    <dbReference type="GeneID" id="36559542"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459117"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000230">
        <property type="entry name" value="Putative dihydrouridine synthase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="47"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="498"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB44618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="551" mass="61642" checksum="7C93AC994E696BDF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVQ5</accession>
    <name>A0A2I2FVQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_439958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700013.1">
        <property type="nucleotide sequence ID" value="XM_024849957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVQ5"/>
    <dbReference type="GeneID" id="36557656"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439958"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014150359" evidence="2">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="169" mass="18980" checksum="FE876E354342BCFC" modified="2018-02-28" version="1">MFRSLYVRLILLWFAFSSCASLALASSPASFCKCTCFSNSTIIPLDPVKPESTSIDGVFNSRSRRTASDDLGNVLDHRASNYRPLSCNDCNRKFCLGYNLPTCKGAKEEDVFTTCFQRDSRKDEAIVFVFIIATSGLLAWAVFKPWVEKYLEKARERRSYIPVSGNGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW10</accession>
    <name>A0A2I2FW10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_458488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700135.1">
        <property type="nucleotide sequence ID" value="XM_024851801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW10"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW10"/>
    <dbReference type="GeneID" id="36559499"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458488"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000091">
        <property type="entry name" value="HLH DNA binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF4">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="317" mass="35011" checksum="560EEDDD6A7AF61B" modified="2018-02-28" version="1">MAYPRADPTPFTLDDDDRMYMSHQSPMQRTNESFPAPKGPDPLSSNWNYDSAIDLFSLNTMLPEPFPMEMPNDMMGMDAKEFPADFFAPPPDISGFTISNHSGEDCASMSSVSNTPPQDLESDDQSWSPTYVAPADLPKPINTTASRPTTRRRTNVQKPREVVPPTNPRWSSSPEITPQEYSAPITTSPQPAPASPPASNRKMTRSLSGDSQSSTGPATTTGRNAAKRAAHNIIEKRYRTNMNAKFVALEKAMCGGVQKSTKGGSASLKKSEILTNAIAYMHELQEENKAMQKELAMYKQGLIPNWDVGTYQVKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWN9</accession>
    <name>A0A2I2FWN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_429738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700329.1">
        <property type="nucleotide sequence ID" value="XM_024847912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWN9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWN9"/>
    <dbReference type="GeneID" id="36555611"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429738"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="266" mass="28333" checksum="B6D0089FC6BBB489" modified="2018-02-28" version="1">MSTPNLKYVGKLSGKRVLVVGATSGIGLCIAEAAVEHGARVILSSSNPTKLDKAAARLQPTYPGLLQTNPLTTHACDLSDSENLERNLTDLLKAASQSGKLNHIAWTAGDALRLPPLEDFTIDSFNRAGLVRCAAPLLMAKILPTYMDLSPENSFTFTGGSNTQKPMRGWAVMVSWGAAIEGAMRGMAVDLQPLRVNIVSPGAVHTELFSGLPKENLDGMLDSFRKASTTGTVGKPEDVAEAYIYVMKDQFTTGSIIESNGGRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX33</accession>
    <name>A0A2I2FX33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell cycle inhibitor Nif1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_274836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700496.1">
        <property type="nucleotide sequence ID" value="XM_024843163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX33"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX33"/>
    <dbReference type="GeneID" id="36550862"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_274836"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000455">
        <property type="entry name" value="Cell cycle inhibitor Nif1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="80668" checksum="8D0BD49487C25C22" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXE4</accession>
    <name>A0A2I2FXE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">P170DRAFT_440440</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700607.1">
        <property type="nucleotide sequence ID" value="XM_024850082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXE4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXE4"/>
    <dbReference type="GeneID" id="36557781"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440440"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000443">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014167060" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="28"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="711"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="24">
        <location>
            <begin position="1010"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="549"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="896"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PLB45305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127696" checksum="360C788171952931" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXG8</accession>
    <name>A0A2I2FXG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative secretion pathway protein Sls2/Rcy1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_513302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700578.1">
        <property type="nucleotide sequence ID" value="XM_024855095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXG8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXG8"/>
    <dbReference type="GeneID" id="36562801"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513302"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000071">
        <property type="entry name" value="Secretion pathway protein Sls2/Rcy1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="890" mass="99416" checksum="985F863DE6227572" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXV6</accession>
    <name>A0A2I2FXV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_499981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700762.1">
        <property type="nucleotide sequence ID" value="XM_024854145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXV6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXV6"/>
    <dbReference type="GeneID" id="36561850"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_499981"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="327"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB45460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="703" mass="76844" checksum="D1BAE3D9A6973333" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXY3</accession>
    <name>A0A2I2FXY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS8m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_439233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700780.1">
        <property type="nucleotide sequence ID" value="XM_024849797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXY3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXY3"/>
    <dbReference type="GeneID" id="36557496"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439233"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="166" mass="18032" checksum="3845D68DAA27CBD6" modified="2018-02-28" version="1">MSLVNLSHVCSHLNNAAKARLGLTSIPNSKLHLKLCLALQSGGYISSVVRGGPTPPPQHTLLGHPDTSNVEPVTQTNVASRRLWLGLKYWQSEPVLGKLKMVSKPTRRISIDVAGLRDVVRGKKSGYVEGLRSPGESLYLSTDRGIMEARECVEKKVGGLVLCRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYP2</accession>
    <name>A0A2I2FYP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_428951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701062.1">
        <property type="nucleotide sequence ID" value="XM_024847865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYP2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYP2"/>
    <dbReference type="GeneID" id="36555564"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428951"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="307" mass="35394" checksum="A89DD4FB05A33898" modified="2018-02-28" version="1">MAPWDEFDSIFYFNKNFTYDGKIIEQIVSNRRALENQLFADRLLRLAGVKAVTKAYPPRSNADLRSLVDQIVSSALDIHHKQALIYYILKDCRAASEAATQFSRRCHLPEKYRLFIEGLWNLDRLEFRRAVEYLTEPSIIPTFPDEILYVLTLPHLPKHDDSLVMAYYLTVSPPLATEGVQRAFFQTLCRSSITEAFFFTRNHQEMLRQAYFELLIEFVHNTEAGQIRSQRAMELIGLPFDDQEEQWLEDTLLRGSAKGLHGSKDTVMMRRLATGKLTGLSPELESLGGKKIDGVNWDVLKKSMKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYQ0</accession>
    <name>A0A2I2FYQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_439486</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701066.1">
        <property type="nucleotide sequence ID" value="XM_024849846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYQ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYQ0"/>
    <dbReference type="GeneID" id="36557545"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439486"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="106"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB45764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="554" mass="64329" checksum="B297605F8B67850E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ20</accession>
    <name>A0A2I2FZ20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_390138</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701179.1">
        <property type="nucleotide sequence ID" value="XM_024845894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ20"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ20"/>
    <dbReference type="GeneID" id="36553593"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_390138"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000238">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="12"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="619"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB45877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="901" mass="102697" checksum="CFDB858FFB92A41B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ96</accession>
    <name>A0A2I2FZ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_458167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701263.1">
        <property type="nucleotide sequence ID" value="XM_024851771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ96"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ96"/>
    <dbReference type="GeneID" id="36559470"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458167"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="141" mass="15208" checksum="BD11D4A99A557204" modified="2018-02-28" version="1">MVSGGCFCGKVRVECSGDLTTSALCHCSGCRKLTGTLFTYSFIVKSADLKVTGTPKEIAKTADSGNHIKNYFCSDCGTPLYGYKVKPTGEPEDITILRAGILDDVSLLDQRKPQVEIYTESRIAWVCPLEGAGQFTGMLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0D0</accession>
    <name>A0A2I2G0D0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_448261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701644.1">
        <property type="nucleotide sequence ID" value="XM_024850952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0D0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0D0"/>
    <dbReference type="GeneID" id="36558651"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448261"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014143398" evidence="10">
        <location>
            <begin position="29"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="431" mass="48153" checksum="F952B9F321CC85F3" modified="2018-02-28" version="1">MWLVSESLALVVLVAVTAPLLRPHGIAGSSIPLVNSRQPFELGYTKARQRCLADMSGFITKGLGKAKIRNSSALSVGRFMAERLHAHLAGFEPWRQVSAPDRLFPETIRTRLMQPLDTRSGKRDGMIEWHRVVLKPSALAIVYSIDSFVAADELHRWPKVFRPVIAWISPSCRKIRGQLREARALMEPILRQRSVRRETGVPAPHDDALEWMEECARGRPYDPAVMAQIGMATVSLHSTADMLTQVLYDLCGRDDLILALRDEVRSVVEQKGLTVSALHDLQLMDSTLKESQRLKPGNATDLHRTDAIVLSDGTRIPRDSYIIVSADRRFNPDVYPNPATFDAYRSMKLRQTAGKETHAQVNTPSPEHLAWGLGKHACPGRNLVVTEIKIALCHILLKYDIKLMDNVRPPPVKNGIAMSANSTAAILVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0M7</accession>
    <name>A0A2I2G0M7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_427748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701730.1">
        <property type="nucleotide sequence ID" value="XM_024847796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0M7"/>
    <dbReference type="GeneID" id="36555495"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427748"/>
    <dbReference type="OrthoDB" id="4501663at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="67087" checksum="4607074A3EC9F510" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G110</accession>
    <name>A0A2I2G110_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_438313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701872.1">
        <property type="nucleotide sequence ID" value="XM_024849573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G110"/>
    <dbReference type="STRING" id="1392250.A0A2I2G110"/>
    <dbReference type="GeneID" id="36557272"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438313"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000022">
        <property type="entry name" value="NADP-dependent alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="332" mass="35775" checksum="F229A125EEC92D6E" modified="2018-02-28" version="1">MGFDFTVLKGSPSGIKKATTHRPDLTHDDVLVRVTHSGVCGTDLHYQDADMALGHEGTGVVEQVGPDVKFLKQGDRVGWGYEHDCCGYCSHCLTGWETMCPERKMYAGANTDQGSFASHAVWREAFLFKIPDALSNEDSAPLMCGGSTVYNAMHVAGVTSSSRVGIVGIGGLGHLAIQFAAKMGCQVVVFSGTDSKREEALKLGATEFYATKGAKELKIGNPLNNLIVTTSSQPDWNLYASVLDNGAVISPLSVSMDEFKFPYMTLLSKGLRVQGSLVSARQVHHDMLAFAAFHGIKPIKMTYPLTADGATECLKTLNDGKMRYRGVLVAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G116</accession>
    <name>A0A2I2G116_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_362631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701860.1">
        <property type="nucleotide sequence ID" value="XM_024844532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G116"/>
    <dbReference type="GeneID" id="36552232"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362631"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="687" mass="77168" checksum="66DDFE6EF4A0A447" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1D0</accession>
    <name>A0A2I2G1D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_511375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701981.1">
        <property type="nucleotide sequence ID" value="XM_024854885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1D0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1D0"/>
    <dbReference type="GeneID" id="36562591"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511375"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="291" mass="32491" checksum="CD6AAC61BD4FB562" modified="2018-02-28" version="1">MMTQQHPRVNRMLTFKRQNSASADGLSTKYGAGKARLRGRKSAKDPLSTPPRRPERRSRSSPATPPATPGPDVITIAVGPEKRLFAAHKEILCVSSFFAAACARAPLSPSGLLAEPLDLPDEQPEVFSCVLEYLYRGDYFPRLLHNKRRDSWEIEDAGTDRHGQSHGATIFHREAGAEILRDTAVYCAADKYNLEMLKRLALRKQGLHTGIQCNTILTSARFAYANTPDHESKLRAHYLALIIRSRDTFKRSGTMQMEMEQGGKLFFDLFVAMCNFMDDTAASQNPKPSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G216</accession>
    <name>A0A2I2G216_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lanthionine synthetase C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_387923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702213.1">
        <property type="nucleotide sequence ID" value="XM_024845824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G216"/>
    <dbReference type="GeneID" id="36553523"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_387923"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000072">
        <property type="entry name" value="Lanthionine synthetase C family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="516" mass="56488" checksum="AE0030E9E2864D7D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2E9</accession>
    <name>A0A2I2G2E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_233154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702360.1">
        <property type="nucleotide sequence ID" value="XM_024842906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2E9"/>
    <dbReference type="GeneID" id="36550605"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_233154"/>
    <dbReference type="OrthoDB" id="10620762at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="178" mass="20111" checksum="08B1E391F2A3E7C6" modified="2018-02-28" version="1">MIAVPQEQQQIIHERWRRLGAHSKRRPQTKPNYSLQRLGGLVFLDHAGTLLSRREAGRVGRLRDLGDGGEGRGKEIQDVEPKGRGGGGREPKHRKRREREQTNEYEAEGEGRGEGKGNKNRAQGARYTSVRTLIFLFWYRPPLVGLAGSGKGSNWQAGKVRQLKGKTMEERGDFQTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G304</accession>
    <name>A0A2I2G304_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_237245</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702553.1">
        <property type="nucleotide sequence ID" value="XM_024842932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G304"/>
    <dbReference type="STRING" id="1392250.A0A2I2G304"/>
    <dbReference type="GeneID" id="36550631"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_237245"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB47251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="150" mass="16677" checksum="11ED295114CC81B1" modified="2018-02-28" version="1">MSTPLDDDPATTTPRDSSVSENPLLRASNPLVSDLEQEVLDEYTRLLGNVNKLSDKLSDLSGDPSSLTLDGLRHLERKTATVCTLLKASVYSIVLQQQIFNESEEQQQQQQQQEQGQGGAYDGDGDVDMGYEDQYQGMMYEGDSFEGRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3M5</accession>
    <name>A0A2I2G3M5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_385159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702778.1">
        <property type="nucleotide sequence ID" value="XM_024845709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3M5"/>
    <dbReference type="GeneID" id="36553408"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385159"/>
    <dbReference type="OrthoDB" id="4191831at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="484" mass="55086" checksum="E73BDC369F311FA6" modified="2018-02-28" version="1">MDASRPPPPQRKGKSPFAQLPRDCLGGILEHLALDDALSLSTSCNDLQASSVPFVLRDVSMDWTSRPRRQVLQLLQTIFKDPERASYVQHVSMMASGDPWDDTQPVGDWETERREFEDVLDQAMDLVRRAGVADADDWHLPIYGGNIYTLATVFLSQLPNLKSLRLDYSFVWWDGYPGIMLKQALLCPNGVFSTFQHLETVEYGANVPIAETHRPDDDEVPDGYPPYNPEQFMAWFCLPSLRHLNIWLRDLEGLEEARPDLDLSNLETLVMARSTATEQHMHFLLSRTPNLKGLHAALAYAWPGEAVLQDSPVFVQALEAVRPTLEKLSLGVECYPSSLGDREWNEADDPAFDPFHQFLTHFTTLRTAEVPLALLLGWYWGESAHLGPLLPSSLSHLCLRDDLRSFYDFEWSEDRAILLLESFLQDWRSHTPSLERITLRLWDQNYTGQRRDQEERLQTVASDAGVELQIVVDDLGSGLWTLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G503</accession>
    <name>A0A2I2G503_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_447781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703256.1">
        <property type="nucleotide sequence ID" value="XM_024850915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G503"/>
    <dbReference type="STRING" id="1392250.A0A2I2G503"/>
    <dbReference type="GeneID" id="36558614"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447781"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000004">
        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014126857" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="176" mass="19027" checksum="768DA7E40AA62796" modified="2018-02-28" version="1">MKLLSSAATLLVCFAPLTVSGRSIALFGSSQAPIQVDTSKSVPGDNPLEFCNDPSGDLIEIESVDLAPNPPLPGKTLTIKAKGNIHKKIEQGAYVLLQVKYGLITLIKQQADLCEQIVNVDLKCPLEEGEMSLVKQVELPSHIPPGKYSVHADVFTKDEERITCLDATNIEFKLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G533</accession>
    <name>A0A2I2G533_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Paf1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_410461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703290.1">
        <property type="nucleotide sequence ID" value="XM_024846848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G533"/>
    <dbReference type="STRING" id="1392250.A0A2I2G533"/>
    <dbReference type="GeneID" id="36554547"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410461"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55924" checksum="532524C793354C7D" modified="2018-02-28" version="1">MSKSKDGGSSGGFHQEYIASTRYRNDLPPPDMPPKFLDIPHEGLDRFLTPGFASNLARREEPNIDVDAEGGMPIDLVGIPGLHLGDESAIMAPENPDPIDPADLPLLMTLDQLRNPAPKNTNVSFLRRTQYISAGIRAPDGPKVTPIRSKSLQDEKTKMSQDDPIYIKKYIQKGFDVAYPESKHSGEDTPSRIKGHNPTKLEHDAWAHPVHPSNPKLKPVGFFPLLPDLEGFPDPGGFVQFKFDKAPVQDVSGKRDKRMDAAVLLPSAPEERVCQEHSTKAALHKTNPSLYPDPGPVPWDYDLFLASKESAKNVLASLRMTNPERDNEALYAHESADNTKFHRYDRVRTYATSAQTLGNDQKQKDVALTLFDPSNANEEQQGKQKAAFYYPILGKTRLKPERARTIAQAGLAPTRPKTKEDQVDQIQVAVRDPDEAEVYKRGLHRAAMDPKFAKTMPPPPEGVADEAESPQEHAEADDREHSVDQQSADQDAPGEADRMSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G587</accession>
    <name>A0A2I2G587_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_510737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703344.1">
        <property type="nucleotide sequence ID" value="XM_024854806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G587"/>
    <dbReference type="STRING" id="1392250.A0A2I2G587"/>
    <dbReference type="GeneID" id="36562512"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510737"/>
    <dbReference type="OrthoDB" id="2935572at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12261">
        <property type="entry name" value="RRM1_3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="165"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="395" mass="44209" checksum="67F769F171E01321" modified="2018-02-28" version="1">MSAFITVEKRHLEHLLSQAEAADRQNVSAENKLLDPDSVTISNSEYKHLLQECERFNRLKESLLNGGLSTESLDVLIYGPTLRETQPNQGVIRENPMGRREVSSPSVDYHHERSNNHGLSTNYDDDDDDDDDEDGLMDPQDSDGKDDCEESSRTTGSFAGTADRRTVLIRNLPDRVTHKDLVENMRGGALLHIYLRAREHLASVSFVEEADAQGFLQHAKNYGFYVAGRRVEVLWNDRQFYMPPFVRAKINNGASRNIILHNANPNITEGLIRRDLDHIHNLIVVAVKFKNGNAYISTNSVHNALFARSCMMSRLTYKGMRIGFYPDECNQPLAKIPTGPKKDVQGGVKKPASIPNRFQLLSLDGGEEEDSDGSEGLNGTHLGNGIHWADNRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5G3</accession>
    <name>A0A2I2G5G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_206377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703421.1">
        <property type="nucleotide sequence ID" value="XM_024842785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5G3"/>
    <dbReference type="GeneID" id="36550483"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_206377"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="160" mass="17889" checksum="EB62C56BE224CCBE" modified="2018-02-28" version="1">MIETPGMGFGLRKQIPLHFGRCWEPCTPPWPAGPIRAPLAMDPSAVQRSRPRMKAGMTSRITIPDPRSLWGARLLILVWPGMALLFAFFAALSGLFCYPELAFHGPYFAEVPFPGSMRLGIVLQRPCTSGTLHEDKETGEAREDEDFPRITPPSRRVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5L0</accession>
    <name>A0A2I2G5L0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_447958</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703471.1">
        <property type="nucleotide sequence ID" value="XM_024850929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5L0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5L0"/>
    <dbReference type="GeneID" id="36558628"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447958"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="69"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="660"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB48169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="813" mass="88073" checksum="5D2B8633C312EE2B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6X1</accession>
    <name>A0A2I2G6X1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_436441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703929.1">
        <property type="nucleotide sequence ID" value="XM_024849154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6X1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6X1"/>
    <dbReference type="GeneID" id="36556853"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436441"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB48627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="385" mass="44163" checksum="02FA460A46AD4AF2" modified="2018-02-28" version="1">MATQLPVTGRRSHRKSRNGCQQCKARKVKCDEGRPTCRNCKKHHVECSFFATTNGSPSPYEVSDTPLISTHADPAAGQTTSTAPELAISDLELLHHFSTSTAYTFSQHPAIQTFWRVNAPRIGFSAPYALRAILAISALHLAHLRPHQKKFYVNQAEYHHDAAVKQVAPNMTHLMQEDSAGVLLFSMLTSFISCAKPRKLDDFLLFRRGEVSEWLVFFRGSGTIVKYARDSLSSGPMAAILNIRGNRTEFRNSLVTDQKSFMSDLEVLIREEVRDMEELKIYLDALEEMKRSYVLWTDQCPTQWETDDVFVWPLGVSQEFLELLREQRPVALVIFGFFCPLLHRLEWMWWINGWAIHLLSRIHGLLDAAHRSWIQWPMEQLGWCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7B6</accession>
    <name>A0A2I2G7B6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_425791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704074.1">
        <property type="nucleotide sequence ID" value="XM_024847672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7B6"/>
    <dbReference type="GeneID" id="36555371"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_425791"/>
    <dbReference type="OrthoDB" id="4395797at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="177" mass="19793" checksum="D6E74283C9E3E3B3" modified="2018-02-28" version="1">MSESYSMSDFTKMVNAIVDQVLELSLLYDCRAYLLVESDNGIVIFNSVEDPLWPPDDRSLRLYSSWEILARAIGEERKDLIQLLVYISEVAKGPLALAAESTQDEQALGAGAFEGPRADEQDEDRIVQEEDNADDEKGEGDQRAVENAEHGEEGRGHETYIWSGDATDWYGSKAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7X1</accession>
    <name>A0A2I2G7X1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA replication licensing factor mcm4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_407833</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704270.1">
        <property type="nucleotide sequence ID" value="XM_024846701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7X1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7X1"/>
    <dbReference type="GeneID" id="36554400"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407833"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="606"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB48968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1025" mass="112538" checksum="80CDE31CAD19E7C8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8G2</accession>
    <name>A0A2I2G8G2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF803 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_436797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704472.1">
        <property type="nucleotide sequence ID" value="XM_024849226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8G2"/>
    <dbReference type="GeneID" id="36556925"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436797"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000012">
        <property type="entry name" value="DUF803 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="591" mass="65237" checksum="F6B2741FD127F029" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8W4</accession>
    <name>A0A2I2G8W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_495065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704585.1">
        <property type="nucleotide sequence ID" value="XM_024854079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8W4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8W4"/>
    <dbReference type="GeneID" id="36561784"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_495065"/>
    <dbReference type="OrthoDB" id="5427633at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF70">
        <property type="entry name" value="RAD21_REC8 N TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G02900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="708" mass="77721" checksum="C28716F65BF48D8F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G904</accession>
    <name>A0A2I2G904_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P170DRAFT_426288</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704664.1">
        <property type="nucleotide sequence ID" value="XM_024847702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G904"/>
    <dbReference type="STRING" id="1392250.A0A2I2G904"/>
    <dbReference type="GeneID" id="36555401"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426288"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="21">
        <location>
            <begin position="56"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="22">
        <location>
            <begin position="496"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB49362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="630" mass="70134" checksum="81672AF529214912" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9F5</accession>
    <name>A0A2I2G9F5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_185417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704812.1">
        <property type="nucleotide sequence ID" value="XM_024842692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9F5"/>
    <dbReference type="GeneID" id="36550390"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_185417"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="109" mass="13417" checksum="C9AF1B6F7466EAE2" modified="2018-02-28" version="1">MSYCSIKLNANKRRMKFDKEKLKSREDRDTALAKNVFTRSTRKGRRRVDQIERTKGEKHEKRKEKREREREREEKERKNEPTNERKKMERENEGYARQIAAEAERILYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9P0</accession>
    <name>A0A2I2G9P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_437178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704897.1">
        <property type="nucleotide sequence ID" value="XM_024849305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9P0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9P0"/>
    <dbReference type="GeneID" id="36557004"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437178"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="133" mass="15153" checksum="89A0858128510635" modified="2018-02-28" version="1">MADTPVTLRTRKFIRNPLLGRKQMVVDVLHPNRANVSKDELRDKLADLYKSNKDQVSVFGFRTQYGGGKSTGFALVYDSTEALKKFEPAYRLVRIGAATKVEKPSRQQRKQRKNRSKKFRGVAKTKGPKKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Q7</accession>
    <name>A0A2I2G9Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein EsdC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_357367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704921.1">
        <property type="nucleotide sequence ID" value="XM_024844214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Q7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Q7"/>
    <dbReference type="GeneID" id="36551914"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357367"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000885">
        <property type="entry name" value="Putative GTP-binding protein EsdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29819" checksum="7CA329553A809480" modified="2018-02-28" version="1">MSAVQLKFSLRTSSNCKTVHLLGSWDNYSRQIPLSRDDSKPGAWIGKFRFQTSMLKLGGRYWYYYIMDGYHVSHDPAVDYTVEPTTGRKLNILDVPGGSSSSSKKSSAPSSAPKTRRTSGDVPTGRALSPSKIHHPKPSKPYASRGLRETDFAPTMDDLTTRFADSRLSDEYSYSNSPPSSVGSSLSSRSSRSSGSTSPSSLSSMSDPPASICRCERYGITRKGDRVKLDCGGSRCGYVTESSEASCSESDSDEEYRRARSGVRRQGIVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA25</accession>
    <name>A0A2I2GA25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705020.1">
        <property type="nucleotide sequence ID" value="XM_024849322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA25"/>
    <dbReference type="GeneID" id="36557021"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437255"/>
    <dbReference type="OrthoDB" id="4161589at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF6">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44736" checksum="F6F2027DE71D34E3" modified="2018-02-28" version="1">MTLSRHNASVSSSDSKRLRDRLAQKAQREKREARMKGLEDRVAFCDQNHGPASMQQYTVTLNRVLEENKRLQEQQVLFRHLLGQFNDVLSEKSSSQTLLPPVANTWHPTPETGLPGTLEMQSQIKSGLQYDSTISSSIGTASVRHEPRIGQRPTEPTMPLSLPTQPSQPAITPNAIPNWSLTPVNEYGMNPAFMPATCPWFSRPDLVAACPPVPAPLDLLYGTRRNYLADEISRGMRRQSLRDPECLASGWLTYVYSKWRVSPNPATFERLPKFLQPLMMQLQRGHPNLIDLIIWPQLRINMIKHWTKYDYCELIDYMSCCTKVRWPWGRDILERDEADNLRIPQDFFDVFTQVSGWGLTTEFIEKYPDLVEGMDVEALRFSYDPAARVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA38</accession>
    <name>A0A2I2GA38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_465066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705042.1">
        <property type="nucleotide sequence ID" value="XM_024852295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA38"/>
    <dbReference type="STRING" id="1392250.A0A2I2GA38"/>
    <dbReference type="GeneID" id="36559993"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465066"/>
    <dbReference type="OrthoDB" id="2103397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="417" mass="47853" checksum="FE26ADE90059AF16" modified="2018-02-28" version="1">MGSSESGSEKVNLAIDDLEKSLDHIGTCWLQRCLLWNRPFTRLVRPPSHLHDQLESYRLGLDIPPSSLIIIHPRVDAILLSIIGSVMEKYRARHGSLPEQLRRMRLEFNQQVTMSHSFDYEEHQYGFQVDDALWYGDRDNLETNLVVQRMEAMSDGKENTLTGALRGSEDSRQIYGIVTDSYKWHFMRVSPSGQLFLKSFDWNKKREQRLILDHLQRITKEANNLAYKVYGNSDLGSQSVTEATGCIVERSFGNKTGKDYLVSVSLGKSNIWPIKGMWLKDAEEAFNLRMEPEQVHLFEPTLVETSSIDHIISVWKMYNLATYKSWVFEQPARPLIELIFLTLISDPMINRCLYLQLGGTDCHIETSCLYRDRSITVHGSTDYSIRKKNDPHSVFPILVAGEWEDGLCPLVAYMAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAQ8</accession>
    <name>A0A2I2GAQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_454641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705257.1">
        <property type="nucleotide sequence ID" value="XM_024851458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAQ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAQ8"/>
    <dbReference type="GeneID" id="36559157"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454641"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="499" mass="55321" checksum="B0BC670F66B0A899" modified="2018-02-28" version="1">MDMSTEKQDATTLDIADQDYVRWTKTNPAHPRNWAAWRKTYDYGLLIFLDFFTTVISTAGTPASEQARHELEIGRSLSLFSFVTIYMLAQAIGGVFFPPYSESFGRKNLFVISTAGYCISSILIATVPHTGMIIVGRFVCGLASALPTIVIAGSAEDIFDVGRRIWMIYLWAVAANVGICMGPIVGTFVTTSIGWKWIFYLSAIVTGVWFFLLLAIKESRPSQLLSKIVDDVRKESGDTIHLQIRNPDHAPDFGTFAQVALIRPVRLFFTEPIVFLCSVLSAVAFGLLYLFTEALPVVYDSFGFTPGQSSLSFIPLALGIFSGTLTRLYDQRIYNRRLQQSRPLEPEDKLAGFAIGAPLLAIGLWWFAWTIPPQVSGVHWIVSMLSLFLVGYATNEFDCTLAGYIADSYTVFAASAFASIAFLRALCCAVFPLFTHRMYTAITPNVATSILAALATVFCVGPVMLVCYGRKIREMSSFAKYSLEQYKHNEVDREPGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAX5</accession>
    <name>A0A2I2GAX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450 monooxygenase otaC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_454673</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>7-methylmellein + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 7-carboxymellein + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:72771"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:192524"/>
            <dbReference type="ChEBI" id="CHEBI:192525"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:72772"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705322.1">
        <property type="nucleotide sequence ID" value="XM_024851465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAX5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAX5"/>
    <dbReference type="GeneID" id="36559164"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454673"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000069">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB50020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="513" mass="58966" checksum="F66035146F0F05AC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB35</accession>
    <name>A0A2I2GB35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_356039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705382.1">
        <property type="nucleotide sequence ID" value="XM_024844126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB35"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB35"/>
    <dbReference type="GeneID" id="36551826"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356039"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="60303" checksum="C53EB30C64EF57D4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBH8</accession>
    <name>A0A2I2GBH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_354449</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705535.1">
        <property type="nucleotide sequence ID" value="XM_024844032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GBH8"/>
    <dbReference type="GeneID" id="36551732"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354449"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1329"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1386"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1494"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1587"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1628"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1666"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1696"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1763"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1827"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="329"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB50233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1903" mass="217806" checksum="87A83D187D79DEF9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBN9</accession>
    <name>A0A2I2GBN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase with different specificitie</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_435474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705577.1">
        <property type="nucleotide sequence ID" value="XM_024848940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBN9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBN9"/>
    <dbReference type="GeneID" id="36556639"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435474"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="262" mass="27704" checksum="14DFC9B656FE59D7" modified="2018-02-28" version="1">MNSQNLFDVKGKVVLVTGGAKGIGRMISEGFVANGATVYISSRDAKACDAAVNELNALGKGKAHSIPANFYKEEDVKKLAEELGKREDKLHVLVNNSGSNWGAPYNEYPSSAWTRVLTLNLHRVFDLTQLVTPLLEKAASAGDPARIINIGSIDGIRVPALETFAYSASKAGLHHMSRVLANHLGKRNITSNSLACGPFESKMMAATLESYRETIEAGIPLGRIGTPEDVAGACLFLSSRAGSYVNGATITLDGGSAIAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBY2</accession>
    <name>A0A2I2GBY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_508578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705692.1">
        <property type="nucleotide sequence ID" value="XM_024854591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBY2"/>
    <dbReference type="GeneID" id="36562297"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508578"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="59178" checksum="5137461806019F18" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC22</accession>
    <name>A0A2I2GC22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative differentiation regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_473993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705740.1">
        <property type="nucleotide sequence ID" value="XM_024853097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC22"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC22"/>
    <dbReference type="GeneID" id="36560795"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473993"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12520">
        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12522">
        <property type="entry name" value="RRM4_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034195">
        <property type="entry name" value="Mrn1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="191"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="282"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="507"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB50438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="836" mass="88416" checksum="5B678A61EA5830F1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC68</accession>
    <name>A0A2I2GC68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P170DRAFT_355076</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705775.1">
        <property type="nucleotide sequence ID" value="XM_024844071.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GC68"/>
    <dbReference type="GeneID" id="36551771"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_355076"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="323"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="22">
        <location>
            <begin position="580"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="101"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="219"/>
            <end position="277"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="895"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
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            <begin position="1243"/>
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            <begin position="126"/>
            <end position="141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00031083"/>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB50473.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1421" mass="156781" checksum="B8D7860BDD24E816" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC80</accession>
    <name>A0A2I2GC80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_463678</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_024705784.1">
        <property type="nucleotide sequence ID" value="XM_024852181.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A2I2GC80"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC80"/>
    <dbReference type="GeneID" id="36559879"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463678"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="48"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB50482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="382" mass="43170" checksum="55302AA6D8588BEC" modified="2018-02-28" version="1">MPKVKQKKRNGAPHGSPYSDAAVKAKAANSVFKMNTDIGQHILKNSGIADKIVEKADLKQSDVVLEIGPGTGNLTVKMLEKAKKVIAVELDPRMAAEVTKRVQGTPVQKRLEVILGDVIKTELPYFDVCVSNTPYQISSPLTFKLLATSPAPRVCILMFQREFALRLFAKPGDKLYSRLSVNAQMWAKIDHIMKVGKNNFKPPPLVESSVVRLVPKNPRPQINYDEWDGLLRIVFVRKNKTIRSSFLGKSTIMDMLEANYRTWCAQNDIPVEDGPAENTDTDAMDTGTHQDEEEEPDEAMEVDDEDDVPDFFKEQASSRVEQALKNRPARKKRGKVAELVREKVRQVLEDETKLAEKRARMCDENDFLKLLWAFNQKGFHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCD3</accession>
    <name>A0A2I2GCD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_435722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705832.1">
        <property type="nucleotide sequence ID" value="XM_024849005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCD3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCD3"/>
    <dbReference type="GeneID" id="36556704"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435722"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="7">
        <location>
            <begin position="332"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="612" mass="66998" checksum="3A095D7107A15BB9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD28</accession>
    <name>A0A2I2GD28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_353656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706091.1">
        <property type="nucleotide sequence ID" value="XM_024843990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD28"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD28"/>
    <dbReference type="GeneID" id="36551690"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_353656"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014136518" evidence="1">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="474" mass="53245" checksum="0D394A8AB34B5535" modified="2018-02-28" version="1">MLLLPLLVLSACVCHAQAKGVFAHFMLGNSDNYTKADWRQDIQAAKDAHLDAFALNTGWGINTRDLLDDAFSIADEVGFKLFLSLDYSGDGHWPEDQVVNVLKAYTNKTAYYRHRDDKPLVSTFEGAQAAGDWQGIKKKVDCVFIPDWSSLEPKVSLGRAAVDGLMSWSAWPEGTHDSNTTVDKKYMDALDGKPYIMPVSPWFYTNMERYHKNWVWKGDDIWYKRWEEVLEMDPEYVEIISWNDYGESHYIGPIHERSLNVFDDAEAPYDYAKGMPHDGWRAFLPYVIELYKNPGRDAKIENEGIVSWYRVNPSSVCSDGKTTGNTETQAQKTYKPEEVLQDKIFYSALLEEPADITVSIGGDNKTATWDDKPDGSKGIYHGSIDTGKKLGEVVVTLSRDKQFLAQMKGKTITDKCDRNLTNWNAWVGNATSTGELAAKHSSSSGDDKDSSSTRVVVGGLLQAAVVWMVFFNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD77</accession>
    <name>A0A2I2GD77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1295 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_406254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706122.1">
        <property type="nucleotide sequence ID" value="XM_024846619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD77"/>
    <dbReference type="GeneID" id="36554318"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406254"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="341" mass="38324" checksum="33BB50B4FF3AF195" modified="2018-02-28" version="1">MATFNPPPLVDIDRYVGQKQSRALNAGDVGIFKSTILPSFTIHSGLSIASFIAAKSTDRGEIKDWCWPSSQVLNAWWSAIGRPMALDDISFSAAWRMLPWTEKVLLSSVTLWGTRLFYRIATRTITRGKDDPRYDELKAKDPGFWKSAFLKMFLPEAVFLTFISLPFTLPFRLSETSLDITPQTAGVLRTVGVALFSAGFALEAMADKQLESHRQERTDLCRQGVWSIVRHPNYLGDALVHFSFVVLNAASSFNPLVLLGPVANYAYLRFVGGDKQNEESQEARYKDQDPHKYVQLQAWRQEKNSFWPSLSELVNPWTWAVVGSAVVGVAVEEGVRGWVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDT7</accession>
    <name>A0A2I2GDT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_493291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706378.1">
        <property type="nucleotide sequence ID" value="XM_024854043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDT7"/>
    <dbReference type="GeneID" id="36561748"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_493291"/>
    <dbReference type="OrthoDB" id="4312109at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="456" mass="52080" checksum="E1F48B20F6E264DA" modified="2018-02-28" version="1">MWSFGRRKGASRKPSPKPAPRSTSKGKNVDKHKTSTSPPDNEDNSPAPDSPLDLSPPLSDLGPIQDSQILSSSSSQTSVDESSTPPTPQLEAFAEDAAKDNPNPSPSPGPNPGPDPGPDPGPSTTAPLQEPNAMSEDPEELVQQLLASLLDPMEEELGRLDRHLDQQALAHSFMRATKYLEQKLPSKAREWVKHAEEISNRLQDTDNQARCMYWFGRIDWFEGRQNDAWWHFKKASLLLPRGSDEMRNIPTYLQWLKLGPGMDRRRARLSRQGFRPPHESEPAPVSRKKAQGSALPFTAVSYNRYSHPGLKRKRENMEPDVAVALDLPDTHGRRRDRSRAVMTFESDRHIHPGEEVEVDPRRLPHLVYDFSWKRPQERQLKPPFNTFEFSRNPKKSRASRFRSHKIFAKQPWEKSGSRRTTRNRTGGKTDFTMETLTDELNSTPYQGLRYDYRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDU1</accession>
    <name>A0A2I2GDU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="20">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">P170DRAFT_446190</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="20"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706334.1">
        <property type="nucleotide sequence ID" value="XM_024850774.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GDU1"/>
    <dbReference type="GeneID" id="36558473"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446190"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 24" id="KW-0349">Heme</keyword>
    <keyword evidence="12 24" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sm" evidence="26">
        <location>
            <begin position="896"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="494"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="955"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1254"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1027"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1255"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1279"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="24">
        <location>
            <position position="2199"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PLB51032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2253" mass="249482" checksum="624D4A2733449750" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE45</accession>
    <name>A0A2I2GE45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_464122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706434.1">
        <property type="nucleotide sequence ID" value="XM_024852222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE45"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE45"/>
    <dbReference type="GeneID" id="36559920"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464122"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000016">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000868">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="316"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="498"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="741"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1267" mass="140362" checksum="7C1008DA2DC38B49" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEG3</accession>
    <name>A0A2I2GEG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_382593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706533.1">
        <property type="nucleotide sequence ID" value="XM_024845608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEG3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEG3"/>
    <dbReference type="GeneID" id="36553307"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_382593"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="106"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="546" mass="60097" checksum="1C5C9284E331D9A9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GER1</accession>
    <name>A0A2I2GER1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_353304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706676.1">
        <property type="nucleotide sequence ID" value="XM_024843973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GER1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GER1"/>
    <dbReference type="GeneID" id="36551673"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_353304"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="659" mass="74808" checksum="79453C107B3A465F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG36</accession>
    <name>A0A2I2GG36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_443969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707146.1">
        <property type="nucleotide sequence ID" value="XM_024850596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG36"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG36"/>
    <dbReference type="GeneID" id="36558295"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443969"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014195022" description="Sodium/hydrogen exchanger" evidence="12">
        <location>
            <begin position="21"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="734"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="772"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="902"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="551"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1101"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB51844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1204" mass="131981" checksum="F8EE308E0FC015DD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG84</accession>
    <name>A0A2I2GG84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="16">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P170DRAFT_350110</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="16"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707149.1">
        <property type="nucleotide sequence ID" value="XM_024843777.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GG84"/>
    <dbReference type="GeneID" id="36551477"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350110"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="22" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="21">
        <location>
            <begin position="572"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="818"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="1394"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="390"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1579"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="649"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="406"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1592"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1603"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1634"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1669"/>
            <end position="1678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PLB51847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1686" mass="189203" checksum="39D107DF953FF12E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGP9</accession>
    <name>A0A2I2GGP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_352165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707309.1">
        <property type="nucleotide sequence ID" value="XM_024843908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGP9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGP9"/>
    <dbReference type="GeneID" id="36551608"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_352165"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB52007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="501" mass="56414" checksum="3D2D8CA12603BC04" modified="2018-02-28" version="1">MKVKQKSVCQTCRTRKLGCDGKRPGCSQCVLSGRFCDGYSTNWTFVSQDDGLPKAKEQHSKWVQQYSKSHLHSPDDVMEHSQYANDSVSLLPSLRPDNNDFMGLIIQNYIPGDQLMITDGITDDKGSRICGSWIEVLPVLENQSARDPVLPTAIKALAGSIGSQKQEANQSILSCSQPYQVAIRALRKSFARPDHTFRTDLIAAAMCLTLVELMLPESLPALTAHVKGVGLLLLTYGPEACKSGALHKLFVGFRPLLVLEAFRHRQPVFLASPEWFEIPFFILSPSLMQRLLSKAVIIPSLFRKCDEILDTPCASDISEIRGICRSFIDIVRQLEDWETSTRVEIGRPYFWNQDKTFSSRSPPTFEESFLWYDNVTMANVFTHLWAFHIVCLSEIERLMLLFPETLLGETSLLSLKDVGDITSRTLTLSKQICLSMEYLMQDEMKLFGPASTFFPLQVANEKLRAYGPANQEYVDYIEQLVGRLVRKGLRSAPILVPTGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH62</accession>
    <name>A0A2I2GH62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707523.1">
        <property type="nucleotide sequence ID" value="XM_024852912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH62"/>
    <dbReference type="GeneID" id="36560610"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472128"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13780" checksum="F9B4A08855862200" modified="2018-02-28" version="1">MLDDLDRRAYMYLGLLISSFATTLGALIITQGVIYGVGFLIFYYPIFNMGNEFWAARRGTAYSLLYIASGVSGAVMPLILEKLLYRFGYWMFLRAVAGVLVLVNGLLIPFLKGHLPASEQSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHQ7</accession>
    <name>A0A2I2GHQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_434172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707711.1">
        <property type="nucleotide sequence ID" value="XM_024848661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHQ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHQ7"/>
    <dbReference type="GeneID" id="36556360"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434172"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="26796" checksum="4BAD714AA3A6E5D9" modified="2018-02-28" version="1">MTDSVNPPLSYEASATTTHPHVATTLPPEVIACLKNSRFLHLATCDDLTPHISLMSYTYLPSTPFDPYPTIIMTTNPSSRKTNHLLTNPRVSLLVHDWVSHRPPTRASNAGEREGSPPPAATRSSLASLLLNLNTSALSSISTTITGAARFPEPGSDEEAWCKERHLENNTFEEEMGLFGQQQQQQQELGQRRTSVSIDSDVRVVTVRVREGRIADWKGGVRDWVVVREGEEQTPLVNGTLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHR3</accession>
    <name>A0A2I2GHR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_453814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707728.1">
        <property type="nucleotide sequence ID" value="XM_024851390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHR3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHR3"/>
    <dbReference type="GeneID" id="36559089"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453814"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="261" mass="29458" checksum="BEFEA4508D57BFAB" modified="2018-02-28" version="1">MPRGPKKHQKRLSAPSHWLLDKMSGTYAPKASPGPHKLRDCLPLIVFIRNRLKYALNGRETKAIMMQRLIQVDGKVRTDPTYPAGFMDVIGIEKTGENFRLIYDTKGRFTVHRIQAEEAEFKLCKVKRVQLGKGGIPFLVTHDARTIRYPDPAIKVNDTVKVDIATGKIVDFVRFDTGVVTMVTGGRNMGRVGVVTHRERHDGGFNIVHVKDAIDNTFATRESNIFVIGQEKPWISLPKGKGVKLTIAEERDRRRAYASQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHS5</accession>
    <name>A0A2I2GHS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707735.1">
        <property type="nucleotide sequence ID" value="XM_024852937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHS5"/>
    <dbReference type="GeneID" id="36560635"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472326"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="357" mass="40368" checksum="184A451B67A86F3F" modified="2018-02-28" version="1">MDPPPPVSRNGFEYYNDEFYVLVHPNHRHRRSTIPELRAFFNTSPNTTSLKDKPAHWYRAQLIHYGLQPIDRKDTATVRLLDALKQGTLRVPEYIERMEREMKSEYNSKKKSALKPGRKRNAPTVKKRLGGFADLDIDREELGAGNPKRSGRLGFSVSNLNINFNIGGFGGARKSAKTTPKVKPELSVLQEMMRMGNSPSRNDDPQSSRGRPRPRLALDPLNGSYKIDSFATDTRNSGMTLRVSGPSLWGEFQLGFVQGILYMAQRPWNISYEDGGGCPFLWRTRDLDTGLGIYGPQHCGEMRFLDDGNVDGIFYNFPDGEGGWLDCEVWGRRIAEVELGIGRDAASMRMEFESIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI83</accession>
    <name>A0A2I2GI83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pali-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_350568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707891.1">
        <property type="nucleotide sequence ID" value="XM_024843811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI83"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI83"/>
    <dbReference type="GeneID" id="36551511"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350568"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB52589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="671" mass="71375" checksum="F87B38939377C3E6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIE1</accession>
    <name>A0A2I2GIE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_378629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707945.1">
        <property type="nucleotide sequence ID" value="XM_024845455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIE1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIE1"/>
    <dbReference type="GeneID" id="36553154"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_378629"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="244" mass="26842" checksum="4C84E6E7DC37FF2F" modified="2018-02-28" version="1">MICQRCRTSILSRLQPQTSIAWSAPSCTRQLPIQRNLFRNYSTDGKPTVSAPPPPPSPRQPGTGDITVPSAVSSATPGVSQPLSTPEGIHTDAKPDKPTKSDSKPVRSSCPAGTMLQGLNYFKNKPNIVAKEDFDYPDWLWTLLEDSKSSKKSEGGVDPSTLNKKQRKRYEKKMAARAALLPPKIPIHHHATDITPAEYNRGESATETALEDATESLEKRAEITKSARDARRKAIREANFLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIE5</accession>
    <name>A0A2I2GIE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707958.1">
        <property type="nucleotide sequence ID" value="XM_024852957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIE5"/>
    <dbReference type="GeneID" id="36560655"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472545"/>
    <dbReference type="OrthoDB" id="4497351at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="229" mass="26143" checksum="A61B01BF3707FC13" modified="2018-02-28" version="1">MLFSRLRRSVRIQKTGHHATGHATGRTTGHTTVTPKTEERRPSFDSAWTLTGGSSLDLCECKQLGMEILHTIAGIPSFSEFETKESGLLCLEDMISLFDKMSLCQKCSEHEHSPEFLGILCNKILAQCQLFRGFLNEMLEQNDQDQQSLLQRDYATATSQERMSLLCSLTYLQMKRLYGCVARLNEKLEEESTFDEDSWSHLRGQCFQLAIDSATLCSRATYFRNSVFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIH6</accession>
    <name>A0A2I2GIH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_434408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707988.1">
        <property type="nucleotide sequence ID" value="XM_024848705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIH6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIH6"/>
    <dbReference type="GeneID" id="36556404"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434408"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="250" mass="27293" checksum="7A986D0906DA998C" modified="2018-02-28" version="1">MNPARSVQRLGRLLPRSSIAAGLPAASRSFASSIPSLSKGATSPRGWTPTPFVTETVGGGWHTYDIFSRLLKERIICLNGEVEESMSASIVAQLLFLEADNPHKPIHLYINSPGGSVTAGLAIYDTMCYIASPVSTICVGQAASMGSLLLCGGHAGKRYCLPHSSIMMHQPSGGYFGQASDIAIHAKEILRVREQLNKIYKRHLTGKKEMSLEEIEKLMERDYFMGAQEALEMGIVDEVLDRRVKGQDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIT4</accession>
    <name>A0A2I2GIT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ADP-ribosylation factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_434512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708097.1">
        <property type="nucleotide sequence ID" value="XM_024848732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIT4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIT4"/>
    <dbReference type="GeneID" id="36556431"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434512"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000832">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB52795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="184" mass="20488" checksum="4B2E0F0E625FC5D1" modified="2018-02-28" version="1">MGGQVSKIMGKIFGTKEMRILMLGLDAAGKTTILYKLKLTNQDVTTIPTVGFNVESVTYKNVKFNVWDVGGQDKIRPLWRHYYSGTQGLIFVVDSSDTARIEEARSELHKIINDREMKDALLLVFANKQDVSGHLSPEDVTNALQLNKLKDKLWYVAPSVATDGTGIFEGLAWLSNNVKTQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIY5</accession>
    <name>A0A2I2GIY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_403324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708099.1">
        <property type="nucleotide sequence ID" value="XM_024846468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIY5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIY5"/>
    <dbReference type="GeneID" id="36554167"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403324"/>
    <dbReference type="OrthoDB" id="5296720at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42880" checksum="DB38BB8D5CC0C4E5" modified="2018-02-28" version="1">MMTPISLSLLEALPNELLDEIISYLATSSPSTARLHQPPSVRISRSDDRPLKNLARSSSRALEVVRPRLFAHVCFDLEDVTEFLSFVSELDLNRYVTSIVVQSRQPTDQVADPFWWRQVLSCLDPLRVTVVAPPPFIGTMLGAEIFEGHTWAFAVPLQIVQLERDSQHLPLGQLSSLEECSSLLETRKWSSVTFNESSSLKAYNHYEYFLFQVPSLLSRWGSIASNRSREVRAALSVRFDNLTSFGFTAVFPFYNHVKLVLNAVELMVNLRSLSIQLAPCEDDKVTEIEQRGSMDPSDPWMEIATGYSLVAHTVKDLGEKDRLVQFIARDYSFDALRTELSTILGEVLDDTDWVHDGNGTWNRRITNSNSVNGVLPIVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ38</accession>
    <name>A0A2I2GJ38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_434572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708149.1">
        <property type="nucleotide sequence ID" value="XM_024848744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ38"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ38"/>
    <dbReference type="GeneID" id="36556443"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434572"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="85" mass="9312" checksum="A375DA1920161F53" modified="2018-02-28" version="1">MPGRPNANSFAGQVGKMLGEKWKALDDKERRPYEEKAAADKKRYEDEKASYNVSTSPAQYPEAGRRAMLTMLAQAGAAASDEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJU5</accession>
    <name>A0A2I2GJU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase family M13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_434862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708444.1">
        <property type="nucleotide sequence ID" value="XM_024848817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJU5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJU5"/>
    <dbReference type="GeneID" id="36556516"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434862"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="83"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="529"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="734" mass="82079" checksum="14CA99C59EC2CADD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK77</accession>
    <name>A0A2I2GK77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_434976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708585.1">
        <property type="nucleotide sequence ID" value="XM_024848843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK77"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK77"/>
    <dbReference type="GeneID" id="36556542"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434976"/>
    <dbReference type="OrthoDB" id="4499616at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="187" mass="20956" checksum="C50BF6DFF61268A7" modified="2018-02-28" version="1">MTSYTPRLQGNPGFFSALQLVKSQSLEEAVQYVWQTIISTWFNSLDGYTVSYKASTLANNNEPDGIAIRVMELAPKIELSTDFAERQILLVQCNRPSSDTPAGWDGIVENRFRDDLSQTLNDSEKLYGAVAIGTKVRFYRFDGKAPYNQQLTQLHAGAIDMNAPNGITEVENMMNYVKANGWQWAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKG5</accession>
    <name>A0A2I2GKG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_445112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708641.1">
        <property type="nucleotide sequence ID" value="XM_024850680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKG5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKG5"/>
    <dbReference type="GeneID" id="36558379"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445112"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="246" mass="25518" checksum="2B6C8FCA50394C12" modified="2018-02-28" version="1">MSIPKPFALHGKIALVTGAGSGIGKAVAACLTQAGARTIVADVNETTGDSSACEIRRAGHDAQFIHADVTRSESVQALIHNTVITYGGLDIAVNNAGLAPDSSPICDLDEQTWDRLLSTNLTGVALCMKWQLRQMLQQGRGGMIVNMTSATTARPHCGMAAYIAAKHGLHGIRINALAPGATATYLTMSTMKALKLIESEVAAGTNVLGRMAQPDEVAQAALWLSSNASSYVTGATIAVDAGYALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKK2</accession>
    <name>A0A2I2GKK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_424150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708712.1">
        <property type="nucleotide sequence ID" value="XM_024847552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKK2"/>
    <dbReference type="GeneID" id="36555251"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424150"/>
    <dbReference type="OrthoDB" id="4157208at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="167" mass="17300" checksum="04092E7C43A42B00" modified="2018-02-28" version="1">MNVNMNLNMDSTPHPFNPPASSTAPYNTTIPSATATAPNPSNPLLFSSPSANTTTVASNPALNPNPHHAPAVDPLHHLQHQHQQLQPGVGHTETSVAPAPGTAESQAPGPGPGLVRQSSATTYPHQIEGAGGPTATAPFLRDFSLVAEAAKRAQMSVVMRDLESVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKL0</accession>
    <name>A0A2I2GKL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative DUF1212 domain membrane protein Prm10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_129196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708689.1">
        <property type="nucleotide sequence ID" value="XM_024842400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKL0"/>
    <dbReference type="GeneID" id="36550095"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_129196"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="830"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="413"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="687"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB53387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="865" mass="93676" checksum="CA7DA5ECBE3378E0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLA0</accession>
    <name>A0A2I2GLA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_469152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708960.1">
        <property type="nucleotide sequence ID" value="XM_024852597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLA0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLA0"/>
    <dbReference type="GeneID" id="36560295"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469152"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014126859" description="TM7S3/TM198-like domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="125"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="789"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="868"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="961"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1082"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1098"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1111" mass="119664" checksum="AA1CE1DE41D93A3A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM58</accession>
    <name>A0A2I2GM58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_431694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709242.1">
        <property type="nucleotide sequence ID" value="XM_024848099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM58"/>
    <dbReference type="GeneID" id="36555798"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431694"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="161" mass="18013" checksum="6D15256446F84FE7" modified="2018-02-28" version="1">MNTPFPLDPNALYILLLDRGDSYLFHWALYLAKSASSGIMYHLINPDTTDPTTWKYEIQGISDGSYFSRVLLALKLGTLDPVVHDAVAGRLGDVPIQYSGRFKENVTCRVWLKEALYALDDEGYVELGRSVNEIDTEATHLAMINKSKRVRSVVTSRGCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMJ9</accession>
    <name>A0A2I2GMJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_469573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709409.1">
        <property type="nucleotide sequence ID" value="XM_024852649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMJ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMJ9"/>
    <dbReference type="GeneID" id="36560347"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469573"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="79"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="516" mass="55571" checksum="188EE9D8C10D8864" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMZ8</accession>
    <name>A0A2I2GMZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_344830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709531.1">
        <property type="nucleotide sequence ID" value="XM_024843487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMZ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMZ8"/>
    <dbReference type="GeneID" id="36551187"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_344830"/>
    <dbReference type="OrthoDB" id="1883964at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721:SF1">
        <property type="entry name" value="OS04G0446401 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="833"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1190" mass="130349" checksum="A488155C35C4F2F2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNN0</accession>
    <name>A0A2I2GNN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative small nucleolar ribonucleo protein complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_505230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709775.1">
        <property type="nucleotide sequence ID" value="XM_024854272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNN0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNN0"/>
    <dbReference type="GeneID" id="36561978"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505230"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001238">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002180">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative (AFU_orthologue AFUA_4G07540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="543"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="776"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="971" mass="105149" checksum="04B867C9D9BEC044" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP44</accession>
    <name>A0A2I2GP44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_470087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709935.1">
        <property type="nucleotide sequence ID" value="XM_024852708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP44"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP44"/>
    <dbReference type="GeneID" id="36560406"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470087"/>
    <dbReference type="OrthoDB" id="4502329at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28599" checksum="6B4EDC355A6E616A" modified="2018-02-28" version="1">MTKSQHWSWTGLIAAFHIGCAVTSTTTHPPWFNGYYVHFQGGATQTETISCEKTSSFATSGSYANCCGTKGEKCPMPTTCLDHTVYMDNGAYYKCGTSSECATMTVYETYPFGEPFVKNVFCWPDWDAHTVYRQLPTFPTSTAATTTGLSASAGSTVPQATVSSTSTSTGTSAADSDSDSRSDSSSNKGWIAGAVVGPVCGVALGLFGVWVGYRKAQKARAMQAEAALAPQVAQSQYIQGGGYPQEAYGRAVYAQPHVELDSSNLHQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPA7</accession>
    <name>A0A2I2GPA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_470157</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710014.1">
        <property type="nucleotide sequence ID" value="XM_024852717.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GPA7"/>
    <dbReference type="GeneID" id="36560415"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470157"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="18"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="966"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2488"/>
            <end position="2565"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="966"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="998"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB54712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="2570" mass="282350" checksum="26F2224E364D40A1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPD6</accession>
    <name>A0A2I2GPD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_483468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710038.1">
        <property type="nucleotide sequence ID" value="XM_024853896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPD6"/>
    <dbReference type="GeneID" id="36561594"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_483468"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="216" mass="24274" checksum="691B712BCF20ADFB" modified="2018-02-28" version="1">MPGAKHSFSKSTIAGKRAKRSSAKAPSYPELDLKPEFIKSVTTNTPRLAGLLGLETNRELVLMVPKDTSVSPIFDSSLDSYRASYNTDPKGPIVANYSPETLYSLCRDRTYDEMVCAPQAPVLMPDDSVFDTKKAMHKNLVIINHTFRFMIAKQSLFGRADLQNSKRVIDPEDWFKAFSTVHWANKASRKRPPGATEPADGPANYETFWLQNTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPT7</accession>
    <name>A0A2I2GPT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_470326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710193.1">
        <property type="nucleotide sequence ID" value="XM_024852741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPT7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPT7"/>
    <dbReference type="GeneID" id="36560439"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470326"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="69"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="345" mass="37369" checksum="9E622199C92F5B10" modified="2018-02-28" version="1">MASSEPPFMHEQRSEMAKLEAAGLELLGPCPPHLGEASIDIPLPDNQSNATKVVWPRLSDELPIRCPLVIYFHGGGLSTCSPDLVLAPARGFATVLSCVVACPTINQLPTHPFPEPVRAAWEACAWMSEVRNLNEGVLKNSGVSVDPGRGLVVGGLSSGGSVAAVIGSIPDAISAGLEGFAGLTPLRNPITGIFSGLPFLVSEPMLPAEYRGIFKSRETAVDNKAILDAMRHDLEARLDVHSPWFSPINLEFSHGRTFQEHPSKVFVYGGEHDLFRDDAIIYGKWFSESAGVQARTTILKGEGHTAWVSPPWPGSHSRMIKEATLDGMAWLLDMEWDKSLEDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQ74</accession>
    <name>A0A2I2GQ74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_398850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710323.1">
        <property type="nucleotide sequence ID" value="XM_024846250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQ74"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQ74"/>
    <dbReference type="GeneID" id="36553949"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398850"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000039">
        <property type="entry name" value="SET domain protein (AFU_orthologue AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="700" mass="78129" checksum="ECFAEC77D6AEAD3B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQL3</accession>
    <name>A0A2I2GQL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_505785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710474.1">
        <property type="nucleotide sequence ID" value="XM_024854322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQL3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQL3"/>
    <dbReference type="GeneID" id="36562028"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505785"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="154" mass="16598" checksum="69930EEB36920968" modified="2018-02-28" version="1">MPSKRTPTTPTTPTSLSSGPKTLTTNSSVIDIAQHVWQQYVATTPQRTLLLDAFMAFLVLIGVIQFVYCVLAGNYPFNAFLSGFCAAVGQFVLTASLRMQTSSDDTSKSTTAAKGKNAKNVDGASEGGISHERAFADYIFGSLILHFFCINFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR03</accession>
    <name>A0A2I2GR03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_505905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710593.1">
        <property type="nucleotide sequence ID" value="XM_024854330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR03"/>
    <dbReference type="GeneID" id="36562036"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505905"/>
    <dbReference type="OrthoDB" id="5418367at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="339" mass="38618" checksum="5614B02F07AF4B61" modified="2018-02-28" version="1">MDNLQNINSPEELGGLLKSCLESQQHDLQVKCPESFLYTQAIENLLKSRPKGNRVWWTYDAENGILKVSIVSRPLHDATTSLAFDFMAHAQDGQFIPSDLHQRLVLSRRGFIMTLPPAPETRSNKAHAWIKYPDVSIVLRASQRIPVVVFETGFTEDAIDLESDAIQWLLRSDGQVQLVIAIEIREDTRTRDILRKEPPATRRLLQLIRSFGTDALKESYGISTSDDDPSDSDPELYKSIRKMITVTDWVGPISVVMTLWELCGTTPVVREKLVVLPRPESPQNPSVKITDLFPTDFQPLIEDFNPNLVKEIDLEYYRELLSDATEDHAFERAVKFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRM5</accession>
    <name>A0A2I2GRM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_422061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710827.1">
        <property type="nucleotide sequence ID" value="XM_024847410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRM5"/>
    <dbReference type="GeneID" id="36555109"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422061"/>
    <dbReference type="OrthoDB" id="4486134at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22476" checksum="AA810EE7139BD80B" modified="2018-02-28" version="1">MSQRVLQRQETPVLLPPLQSLHSSIMPEYADSPSDSSSSAAECPYCVSPSIPDLATLAETIPDGESGTLSLATLEDQFLRTVVNQPATESTTQVISIVPRDQRSSAYWSLVTLLCHRTFATYGNQTSIRNFSVSYHTKFEPGDVLRAVCRKVTQRRLIWFKATVTQNDVLVANASALYDEIHPEPVNNEEAPEIRISATLNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSJ7</accession>
    <name>A0A2I2GSJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_433311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711142.1">
        <property type="nucleotide sequence ID" value="XM_024848457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSJ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSJ7"/>
    <dbReference type="GeneID" id="36556156"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433311"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="662" mass="73829" checksum="1DAD3621ADA247CC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSQ2</accession>
    <name>A0A2I2GSQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_396642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711192.1">
        <property type="nucleotide sequence ID" value="XM_024846129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSQ2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSQ2"/>
    <dbReference type="GeneID" id="36553828"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396642"/>
    <dbReference type="OrthoDB" id="5346728at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB55890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="711" mass="82225" checksum="0DB61B777EFCE396" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRT3</accession>
    <name>A0A2I2FRT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_75655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698618.1">
        <property type="nucleotide sequence ID" value="XM_024855370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRT3"/>
    <dbReference type="GeneID" id="36563077"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_75655"/>
    <dbReference type="OrthoDB" id="4510969at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014160031" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="34688" checksum="95913BEA6353F924" modified="2018-02-28" version="1">MAVKNRLIQLLVASAIASSAVAVPVAEQQPHVDVISSNSAFHDYLTNVDEHSIHKFMELLGQYRSEHAAHSTSPIIKMGKRDGGSSAVEQPKPTTEAAPEPQTTAAAATTTEAPATQQTTEAPKTTQAAPETSSSKSEEAPSTTQAPPTTADKPSTTEKPPTTEKAPTTEKAPTTSETHAEPTTTKAQPTTHTTEAPKTTHTTEAPKTTHTEPSTTSEKEKTTQAPTTVQTTTSEKDHTTSEKDHTTTEPENTHTTPYTSTYKSTTTLPNGEQSTVTAVTVVHPTRTNHAAATGSGTGPAPGLQTDSAASTNGLGRELFVMMGGAAMVAMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSB8</accession>
    <name>A0A2I2FSB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_393287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698832.1">
        <property type="nucleotide sequence ID" value="XM_024846013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FSB8"/>
    <dbReference type="GeneID" id="36553712"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393287"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1499" mass="167398" checksum="17943AE8FD4CA1A5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FST6</accession>
    <name>A0A2I2FST6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_441142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698984.1">
        <property type="nucleotide sequence ID" value="XM_024850245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FST6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FST6"/>
    <dbReference type="GeneID" id="36557944"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441142"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="390" mass="43059" checksum="38BACA052AAC7901" modified="2018-02-28" version="1">MDDASDGKSVALSSLGDDDQLAGRTRSGSASSGHKRSSSGSLLSKLSFLRMIQATQNTPERSHSGLDRPDGDDFGASLRGGSRAMSSALQHRRTRRRRGSLRKAALLSTRLDFRDKKTNRAPVDVLRADEPSEQHHRPQHPHLFPPHTPPSLPSNSTTPLRPLASPISPEHEITPHEPSYREATNSGENSEWNMMNAPQRSLSTSSPSAPRHQQNPSKDSLGEITTDEEDIMSFPRVKNTNAAVAAAAGLHLPAASPSSDSYYALQADPKYRAMHRAKSPLATHPADMTTSQEMVWDYSETEWWGWIILIVTWLVFVVGMGSCFSVWSWAWDVGETPYAPPELEDDPTLPIVGYYPALIILTAVMSWVWVIIAWVGMKYFKHANISGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT93</accession>
    <name>A0A2I2FT93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_369662</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699136.1">
        <property type="nucleotide sequence ID" value="XM_024844917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT93"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT93"/>
    <dbReference type="GeneID" id="36552617"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369662"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB43834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="808" mass="90574" checksum="0ED8CF646A436D22" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTR1</accession>
    <name>A0A2I2FTR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_368920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699308.1">
        <property type="nucleotide sequence ID" value="XM_024844881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTR1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTR1"/>
    <dbReference type="GeneID" id="36552581"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368920"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000089">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="316"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="513" mass="56775" checksum="64E671FCB3FD1963" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUU9</accession>
    <name>A0A2I2FUU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_503159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699727.1">
        <property type="nucleotide sequence ID" value="XM_024854199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUU9"/>
    <dbReference type="GeneID" id="36561905"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_503159"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="221" mass="25064" checksum="9C3C933BE833DEB4" modified="2018-02-28" version="1">MELRYLLVGGEDADAGQYEKDLMTVLIELDAVPTLRGARRQQPYLTEFFGNVIPREENDEDLRKERCREKYDALFFYLSKVRAFKAWDQSAKSRITEEPLIEELREAQIDALRADLGRIHAECEVVFASQSLLNTDQQGVDSGSATFAIMTVKSLCLCATIMLHQAVHHTAKTDQQAQSAAQELIRLARLMRKFKCLASPCSIIWPLPVYFAGIAVTDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV97</accession>
    <name>A0A2I2FV97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome p450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_440820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699871.1">
        <property type="nucleotide sequence ID" value="XM_024850172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV97"/>
    <dbReference type="STRING" id="1392250.A0A2I2FV97"/>
    <dbReference type="GeneID" id="36557871"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440820"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="513" mass="58609" checksum="1DDD4F5BF7242858" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVR9</accession>
    <name>A0A2I2FVR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">P170DRAFT_367857</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Fatty acid synthase is composed of alpha and beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 23">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699968.1">
        <property type="nucleotide sequence ID" value="XM_024844827.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FVR9"/>
    <dbReference type="GeneID" id="36552527"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367857"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 23 26" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 23" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="28">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="29">
        <location>
            <begin position="1096"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="24">
        <location>
            <position position="1278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1745"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1746"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1747"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1845"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1846"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="26">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00065422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="PLB44666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1859" mass="204671" checksum="CD61820C55862D33" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW66</accession>
    <name>A0A2I2FW66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_415688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700184.1">
        <property type="nucleotide sequence ID" value="XM_024847076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW66"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW66"/>
    <dbReference type="GeneID" id="36554775"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415688"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="240"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="426" mass="48451" checksum="A4E0022428F144F4" modified="2018-02-28" version="1">MDKRSAESPMDFEWQTRAPGDVTSPFYQLSMQHDNQKKRPHSIFDSPPKKQMPALREPNSQPFLFSRQPQSQQPPSTPKSVFGKSAAFMTPRKFDVDFSSGPENMSSPECADNEDTPEPPTKSGHRNSLFNMYGRFAPSPGRGEIPRMNHYSNALARRVHKRRRRDKALDLQLRREGSDDEDESDHDRPSSREEQSLQKKQPKRGQGQMGVEGQQPASRSSSFSDFFALLEAHPNIPSILSWWAQLVVNLSLFSLTVYVVFGFVSTIRSEFEQAAEEVSDGILAEMATCARNYVDNRCAGHDRLPALETVCENWERCMNRDPAKVGRAKVSAHTMAVIINSFIDPISWKAILFFLATISTVTVVSNWSFRSFRKNRLHQQEYASTHAYPQPPPTQHNPSIAYQGHTSSFDRKQDNPFLVEHSQTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW84</accession>
    <name>A0A2I2FW84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_391362</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700202.1">
        <property type="nucleotide sequence ID" value="XM_024845938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW84"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW84"/>
    <dbReference type="GeneID" id="36553637"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_391362"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB44900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="102" mass="11951" checksum="B138F253F3B489C1" modified="2018-02-28" version="1">MICHIGRPSDKQQNKHPPARKTLYIYTEAKMESPHEHQQALLLQRIINNIEKLNESVMAMNKSLQEVNIQNMNVELVAQMFKNYQSNVLFHLEATENYKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWP7</accession>
    <name>A0A2I2FWP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_513133</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700371.1">
        <property type="nucleotide sequence ID" value="XM_024855072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWP7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWP7"/>
    <dbReference type="GeneID" id="36562778"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513133"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="279"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="596" mass="67656" checksum="13A90505A2FC4A8B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWR8</accession>
    <name>A0A2I2FWR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">67 kDa myosin-cross-reactive antigen family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_458635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700367.1">
        <property type="nucleotide sequence ID" value="XM_024851812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWR8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWR8"/>
    <dbReference type="GeneID" id="36559510"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458635"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417:SF2">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="896" mass="102377" checksum="CF81216270CC1564" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWU6</accession>
    <name>A0A2I2FWU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial protein import protein MAS5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_366435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700379.1">
        <property type="nucleotide sequence ID" value="XM_024844755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWU6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWU6"/>
    <dbReference type="GeneID" id="36552455"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366435"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="134"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="134"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB45077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="414" mass="45289" checksum="ED7A919E5A20F2DC" modified="2018-02-28" version="1">MVKDTKFYDTLGVSPTATEAQLKTAYKKGALKYHPDKNADNPEAAEKFKELSSAYEVLSDSQKRSIYDQYGEEGLEGGGAGGGMGAEDLFAQFFGGGGGGFGGMFGGGMRDQGPKKARTIHHVHKVNLEDIYRGKVSKLALQKSVICPGCDGRGGKDGAVKSCTGCNGTGMKTMMRQMGPMIQRFQTVCPDCSGEGEIIREKDRCKRCVGKKTVVERKVLHVHVDKGVKNGHKIEFRGEGDQMPGVMPGDVVFEIEQKPHPRFQRKEDDLFFQAEIDLLTALGGGTINIEHLDDRWLTVNIAPGEVITPGSIKVIKGQGMPSYRHHDFGNLYIQFDVKFPEKDQLQNLNLLDQVLPPRMEQAKPPTDAMVEDFELEEIDGSEYSQARAHGAASGMDDDDDDVPPGAERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWX2</accession>
    <name>A0A2I2FWX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_513175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700426.1">
        <property type="nucleotide sequence ID" value="XM_024855076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWX2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWX2"/>
    <dbReference type="GeneID" id="36562782"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513175"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="301"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB45124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="500" mass="57945" checksum="C09A806662081B3A" modified="2018-02-28" version="1">MIRQDFQRVDPKRRSNLDHKKTQFAVPIFKQQDYPHRLNFYEVPPTAEITLEQFEQWAIDRLKVLAEIEACSYRNKSPAETATHITPLLQKFLPLSSNTSSTLGAADPRLRNERQKDHYSHFTLRLAFSGTEELRRRFARAETMLFRFRFQQDDTKEKRDFIESLSLDWDPVSDDERDALSEHLIGATPGLRQVNEEAWYKVDWERVPELVEKRSVFLSKGKAYVPGKEQLSMIMAEFTARLERALELTSRALPRLDEDDRLTPILDHLSKNFGSADSTYSEGEGVVDGAAITAHNIDKLSQHFPLCMRSLHMSLRKNNHLKHYGRLQYTLFLKGIGLSLEECIIFWRQSFKGFSDDEFNSRYKYNVRHAYGDVGGDVNRRGRGYPPYSCQKILGDSNPGAGQTHGCPYRHFSVDNLVGLLQSTGVHDKDLLRGVREDVEKTRYHIACNRVFDWVHKSDIKRVKEDGSWNQMDLDTIVHPNTYFKRSYLLKQAGRAPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX88</accession>
    <name>A0A2I2FX88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_277887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700557.1">
        <property type="nucleotide sequence ID" value="XM_024843174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX88"/>
    <dbReference type="GeneID" id="36550873"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_277887"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="149" mass="16646" checksum="42ED3A02B83F47D1" modified="2018-02-28" version="1">MLTIASLPRRRSNDSGRSPDSGVAHCCLNDDQPKARQRREKKKKKKRERETGKLRSWTRKATLRGRPNGNVACPSAHLVASEESPSSSNLLNHWPVIGKRVGSVSPPALEERVANARCKDAPSKPDESELLEEATSRDTSWWTSSFQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXJ4</accession>
    <name>A0A2I2FXJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_513329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700608.1">
        <property type="nucleotide sequence ID" value="XM_024855098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXJ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXJ4"/>
    <dbReference type="GeneID" id="36562804"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513329"/>
    <dbReference type="OrthoDB" id="4227586at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB45306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="912" mass="101070" checksum="E229C73B74232E62" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXL2</accession>
    <name>A0A2I2FXL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_365829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700673.1">
        <property type="nucleotide sequence ID" value="XM_024844728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXL2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXL2"/>
    <dbReference type="GeneID" id="36552428"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365829"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021605">
        <property type="entry name" value="Pcf11_Clp1-ID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11526">
        <property type="entry name" value="Pfc11_Clp1_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB45371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="652" mass="70813" checksum="0BCC67FD17A5116A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXP9</accession>
    <name>A0A2I2FXP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_478374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700711.1">
        <property type="nucleotide sequence ID" value="XM_024853555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXP9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXP9"/>
    <dbReference type="GeneID" id="36561253"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478374"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="409"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="813"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="815"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="871" mass="94666" checksum="196FB665FCAAA5C8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXQ8</accession>
    <name>A0A2I2FXQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_243501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700720.1">
        <property type="nucleotide sequence ID" value="XM_024842966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXQ8"/>
    <dbReference type="GeneID" id="36550665"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_243501"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="83" mass="9557" checksum="FBD43B302263BBED" modified="2018-02-28" version="1">MDSPGSNRRSSRYRKRKSMLLVFVCTASVFLMATSCSFLSLQRAFLFLFFFFAVIALIFGSVAFRSSLYLPVHILHLMLYNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY58</accession>
    <name>A0A2I2FY58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_478527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700873.1">
        <property type="nucleotide sequence ID" value="XM_024853568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY58"/>
    <dbReference type="STRING" id="1392250.A0A2I2FY58"/>
    <dbReference type="GeneID" id="36561266"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478527"/>
    <dbReference type="OrthoDB" id="4424568at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="526" mass="58585" checksum="E41B737D4088C878" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYN4</accession>
    <name>A0A2I2FYN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAVE subunit 2/Rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_389868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701045.1">
        <property type="nucleotide sequence ID" value="XM_024845885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYN4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYN4"/>
    <dbReference type="GeneID" id="36553584"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_389868"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34740" checksum="3A049102699D94FF" modified="2018-02-28" version="1">MATWAYPPLPPERLEQEADSALAKELEWLLRNLQDSLASLREGLHECEALLAPKEPGSTLVLSSLRSENVKGFVTRVGTKIVKGDIQLRLSSLASMRGSPTTRLCLSSGPDAPELMLNQLASVRNLVSQSLDVVDVSTWTGDPLNASFIFGQLHLLHETISEARQMLKGENDKVRGKWCETSAAEDMFDPPLPPSLSFHLSIADSALVLYLRTLEPTTPNHTPTAFATDISLTGFNLRDRIFGTRHRPHDEAGDVFTWKGEEVRVKEKVRVESQDPSLMAVMAKLTALQHEVMKWISALKVLMGIEDSESDTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZ52</accession>
    <name>A0A2I2FZ52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_255529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701211.1">
        <property type="nucleotide sequence ID" value="XM_024843047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZ52"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZ52"/>
    <dbReference type="GeneID" id="36550746"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_255529"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013987182" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="309"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="463" mass="51469" checksum="DD84AB7AD494B1F1" modified="2018-02-28" version="1">MRWCLSLLVLGFVAVAHALSSSGNRLAVILEDAADKELYSTFWGDLQARGYNIFFESPKNERFSLFEYGERAYDHLLILPPRSKGFGPSLTPKNIVDFMNKDGNVLLALSGKSTTPSAISSLLLELDFHLSADRSSIAVDHFNYDVLSAAEKHDVLLLQRPGQLRPDTKAFFDGEGVLAFPSASPHTLGDSSQLVAPILRAPTTAYSYNPKEDAPTAEDVQATGSQLALVSAMQARNSARFTLLGSVDSLQDKWFSATVKTPGSGKETKTANQEFAKQLTAWAFKETGVLKVGKVEHYLAKDGEITADELNPSLYRIKNETVFNIEVSEYDYDSFVPFEVPANDALQLEFTMLSPFHRLDLQPARRTANSTIYSARFVVPDQHGIFSFRVNYKRPFFTNIEEKHEVTVRHYAHDEYPRSWKISGGWVWIAGLWSVIGGFLAFVVVWLYSAPAATAAQSSKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZH2</accession>
    <name>A0A2I2FZH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_467193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701326.1">
        <property type="nucleotide sequence ID" value="XM_024852464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZH2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZH2"/>
    <dbReference type="GeneID" id="36560162"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467193"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="695"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="819" mass="94824" checksum="4F4CB1E2E26EE338" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZR4</accession>
    <name>A0A2I2FZR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_429257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701413.1">
        <property type="nucleotide sequence ID" value="XM_024847881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZR4"/>
    <dbReference type="GeneID" id="36555580"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429257"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="314" mass="36090" checksum="7EF91B41E6300E76" modified="2018-02-28" version="1">MSTPNEQRQVIALAGNGNLSRYLIEELCKDDRYAVAVLTRQEPPTNPTPNLTYHQTDYTLPSLISILTSTRATTLISTLNPPEPLYLPLHTTLLSACLDSPLCKRFIPSDWAGNVEDFPNIPRMYGRTRAPFRETLRQTPGIKSTSFNFGWFMDYFLTEEKSYMAFLEGEFPVDPRPSVWRWVVRGTGEEPQAWTCARDVARAVVVLLGCEEWEPVTYITGQRGTYKEMVKILERFYDRPFRTTHRSLDDINRTIANPSTKAELTIAEVEEWEVSGATACPEEKTERQYEKFFKGMKFMSVEEMLRKAETEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZY3</accession>
    <name>A0A2I2FZY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_262596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701492.1">
        <property type="nucleotide sequence ID" value="XM_024843090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZY3"/>
    <dbReference type="GeneID" id="36550789"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_262596"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="155" mass="17386" checksum="DBD59C595FAC75D2" modified="2018-02-28" version="1">MLLSKSLCKSQIKTPSTYIQTFNLPRYLSSPSNRYIPHLLYHTTKYYTNQPKCPTTPSPPHKIPASQAPPNSSPRRWATPSAASPAPSAESRALPPAASEAPLTAPRAAQDSLSAMRWGVLGVEWRTERREWRREWRMLVLDMDRAVIDSGSEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G039</accession>
    <name>A0A2I2G039_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_364473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701545.1">
        <property type="nucleotide sequence ID" value="XM_024844641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G039"/>
    <dbReference type="STRING" id="1392250.A0A2I2G039"/>
    <dbReference type="GeneID" id="36552341"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_364473"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="528" mass="60290" checksum="F6ABFB2457EA8890" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G055</accession>
    <name>A0A2I2G055_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_512753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701508.1">
        <property type="nucleotide sequence ID" value="XM_024855018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G055"/>
    <dbReference type="STRING" id="1392250.A0A2I2G055"/>
    <dbReference type="GeneID" id="36562724"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_512753"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="368" mass="40057" checksum="B9B13394F90E13A8" modified="2018-02-28" version="1">MTYVNKESVTTIGIIFPILVVVSLGIRALGWRRNSRVLGVDDFLIVPAAVLTIAAGVAMVIGAQMDIVGGHSSLGITPPKQRQVGKFEYAFWIGHVLAIGLIKLALLFLFRRIFKGSAYQTPFDYANWTLIVLVTLWTVVFLFIQIFACGADPSRGWASLESLRSKCVDTFAMQTGCAVFSWVMDLAILIEPLFMIAPLKMSFRKKLQVSLVFFCSIFAVIAGLLRMIGWIQIVMQGTQNPTTKILSTVLPSIDQEGIVSIILFWTYVEIGVGFQVACLPPCARHLDKLSFARVLDKMGSWPSALTLLSSGRRGRGSRNHTSGSGSQGHAPSLGYAVQSFKGGKGSRGSRSEDEIELYGVSTPVGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0B9</accession>
    <name>A0A2I2G0B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_429441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701622.1">
        <property type="nucleotide sequence ID" value="XM_024847889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="36555588"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_429441"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="437"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1403" mass="158402" checksum="C86A8B6143086392" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0X9</accession>
    <name>A0A2I2G0X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_477376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701798.1">
        <property type="nucleotide sequence ID" value="XM_024853451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0X9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0X9"/>
    <dbReference type="GeneID" id="36561149"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477376"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="150"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="331"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="438"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="792"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB46496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="896" mass="100178" checksum="F195E8A8748BFEB4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0Y0</accession>
    <name>A0A2I2G0Y0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_438288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701834.1">
        <property type="nucleotide sequence ID" value="XM_024849564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0Y0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0Y0"/>
    <dbReference type="GeneID" id="36557263"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438288"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="33709" checksum="E1F9AC1B106D6EE9" modified="2018-02-28" version="1">MELSTGFTSNAQTQSPGSQGVDYRVPPRRASPVPLTLNTQFGNGQNAGDIGGGGLFKDSVGEFSPHGLDIPRIEVFDCADLSPTSLTPTPSLPSAGSVASSPMSATLDAGLTAPHFALALSPPMSTCPSPSFDSLPYLSPTSLAESSASRRSSVSSLGLDMDWGTSSLPLSESPDEDLGLNAFSPLPSDAQIPAVPTRFEAETLLELFFDRTQGLGYPVDQGRFRAFLDIIDAPYDGPFGPNNPQPVSMAKFHVYMAMAIGLRLKTDGRATESRLLESCYRLALDQIRSPRFWGQPLAGEAAMLMVLFARASQDRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1E5</accession>
    <name>A0A2I2G1E5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NPR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_448493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702001.1">
        <property type="nucleotide sequence ID" value="XM_024850967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1E5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1E5"/>
    <dbReference type="GeneID" id="36558666"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448493"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="737"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="841" mass="93597" checksum="C1191C784C740665" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1V0</accession>
    <name>A0A2I2G1V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_412177</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702150.1">
        <property type="nucleotide sequence ID" value="XM_024846924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1V0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1V0"/>
    <dbReference type="GeneID" id="36554623"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_412177"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014126841" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="29"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB46848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="426" mass="46830" checksum="497BAF0BC3EAB580" modified="2018-02-28" version="1">MYFRWTPLSLLPLTLGIASLGNAPGVEAKDQVCTVRALGNRTDDVPNLLQAFHRCSSGGTIVFPEDQSYWIASRLNPVLHDVTIEWRGKWTFSDDLNYWRNHSYPVAFQNHRAGFVISGRKISIDGYGTGGIDGNGNVWYTAEAGDTQPGRPMPFVFWNASEVNVENFYVKDPQLWALNIMNGTNMRFNNIYCNATAVNAPWGENWVQNTDGFDTMDAHNIQLTNFVYQGGDDCIAIKPRSYDIDIQNVTCRGGNGIAIGSLGQYLEDSSVENVRIDRVKIIRYNEDMHNSAYIKTWIGKRVPQDDYESGGVPRGGGWGQVKNILLSNFEIQGADAGPSINQDSGDNGSFSGSSLMTVSNIAFTNFTGYIQDDDPVTSTVSCSKKNPCHGITFDDVVLYPGQNGTRPGIGSCQYTAKSGVQGLEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1Y6</accession>
    <name>A0A2I2G1Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HNRNP arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_438593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702195.1">
        <property type="nucleotide sequence ID" value="XM_024849634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1Y6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1Y6"/>
    <dbReference type="GeneID" id="36557333"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438593"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="173"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="352" mass="39978" checksum="C2B6BA09A855B59C" modified="2018-02-28" version="1">MNGSERQQSADPAAMTSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDAIYQNRHIFKDKVVLDVGCGTGILSMFAVKAGAKHVIGVDMSSIIEKAREIVAVNGMADKITLLQGKMEEVVLPYPKVDIIISEWMGYFLLYESMLDTVLYARDRYLVPGGKIFPDKATMYLAAIEDGEYKDDKIGFWDNVYGFNYSPMKEIALTEPLVDTVEMKALVTDPCPIITLDLYTVTTADLVFKVPFSLPAKRSDFIHAVIAWFDIEFGACHKPIVFSTGPHAKYTHWKQTVFYLRDVLTVEEDETVSGVLENKPNDKNKRDLDISISYKFETSDPIRQSEGNCFYKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2Z0</accession>
    <name>A0A2I2G2Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_237116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702541.1">
        <property type="nucleotide sequence ID" value="XM_024842929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2Z0"/>
    <dbReference type="GeneID" id="36550628"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_237116"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="80" mass="9030" checksum="CB497EF216DD77E1" modified="2018-02-28" version="1">MLFFKPAIAPSFCRVLSFSCVLSPITEWIWSWGNIIEFPMEGKAPSHRGASSLPRICYDITHHFSTCAMPAESPISKVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4B3</accession>
    <name>A0A2I2G4B3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_359719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703013.1">
        <property type="nucleotide sequence ID" value="XM_024844371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4B3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4B3"/>
    <dbReference type="GeneID" id="36552071"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359719"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF193">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="73" mass="8207" checksum="2183D16ECEB6FA16" modified="2018-02-28" version="1" fragment="single">MTVLSNAAYRGMVDVVKMLLEREVDLDHVDKSGRNSLSWAAEGGHVEVARLLIDKKVDLVLEDEEQMTPLLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G507</accession>
    <name>A0A2I2G507_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear pore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_447790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703267.1">
        <property type="nucleotide sequence ID" value="XM_024850916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G507"/>
    <dbReference type="STRING" id="1392250.A0A2I2G507"/>
    <dbReference type="GeneID" id="36558615"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447790"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB47965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="374" mass="42317" checksum="7678B43FDCDA5E2C" modified="2018-02-28" version="1">MSGFADFDAGHRDLVSVTKFNFYGNRIVTASSDHRMKVWDQKDGEWQLTDTWRAHDAEIRDATWNGPFTGQHIGSVGEDMKCKIWQEDVTQPPNSGRRFRAVFRMTAPQRHPFVSIDFRNIDLESYFAVITRDGYLMVMEPVTPDTLTDWQPLDQFRVCTAPERGEETSFRVQFHQDPTDITHSVLPSWDRKSLSLVVAAMDSVKIYRTDANRRFYHAIELSGHGGLVRDISWANGSVRGYDLIASGCKDGFVRIFEVYTTLSNHGTQNSNGDHVEPIHQTSTRATTQSGIGSALANRTPASISSRAATDDNQFKHSYKEVACLDSKHLDVWQVGFSYAGDCLISSGDDGIVRFWKKSLSGEWLEYAETDMTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G556</accession>
    <name>A0A2I2G556_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_437718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703313.1">
        <property type="nucleotide sequence ID" value="XM_024849430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G556"/>
    <dbReference type="STRING" id="1392250.A0A2I2G556"/>
    <dbReference type="GeneID" id="36557129"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437718"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="161"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="299" mass="32151" checksum="C390EB4F21D71FC7" modified="2018-02-28" version="1">MASASTHYPHRDSHDDESILDDDVIDADDAIEADDPLHDTSDTAPLRGNIQSESSSSGGRNLSGNYLTSSIPGEDRRATHNTIDESVWDTVSRDLLAVWEKLRQVLWPKYLIGGMLQRGGGGIGAAERGEATGFGGGLRNIAGRWPDADMVLQGGMSEGLRDWDLWGPLIFCLLLSMFLAFRASEDQSDLVFSGVFSIVWIGEAVVTLQIKLLGGNISFFQSVCIIGYTLFPLVIAALLSALGLPTIARIPVYLVLIAWSLAAGVSILGGSGVLRNRVGIAVYPLFVFYIAIGCLCFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5W5</accession>
    <name>A0A2I2G5W5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_209465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703574.1">
        <property type="nucleotide sequence ID" value="XM_024842806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5W5"/>
    <dbReference type="GeneID" id="36550505"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_209465"/>
    <dbReference type="OrthoDB" id="4503294at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="12145" checksum="588E0F1E246426DB" modified="2018-02-28" version="1">MFLLNRHPVSPKKAVPKTCSALVDDLPELVHALLTSLLYYLTSMGRAVVALTSADLLSHSGARSASLCTVDDIPLGVSAATVVLVEILRAHFENWFLWKFERCEGSGATWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6I3</accession>
    <name>A0A2I2G6I3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_360940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703775.1">
        <property type="nucleotide sequence ID" value="XM_024844442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6I3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6I3"/>
    <dbReference type="GeneID" id="36552142"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360940"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB48473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="479" mass="52063" checksum="78FA2A6B8FB9C915" modified="2018-02-28" version="1">MDSFQKLPDTESDKGPEVVNYEVDWKGPDDPNKPMNWPKSRKQGIIIAVCAMRFTTPLASSMMSPALLVIGKDFPDASETLLSFSVSIYIIGFGLGPLLLAPLSEVYGRNVIYHVGNIMFTVFTVCCGLSPNIGALLAFRLMAGFFGGAPLTNGGGTIADLVPAEKRGLIMSIFSASMLMGPVLGPVIGGFLAEVGWRWIFWVLTVLSGLTTIVGFIFLRETFAPVLLEKIARQLREKTGDSRYYAKGKSDKKLSHLLLGAVTRPTRMLVNPIIIGTSVYMAVMYGIIYLLFTTFSVVFQRNYGFKEGIAGLAYLGIGVGSALGMFLFGRYSDRIYSRLTSKHQQAKPEFRLPPLIPSAVSMPVGLIIYGWTAQYKLHWILPIIGTGFSGLSVMGCLASIQAYLVDEFTVFAASALAANGLIRSIAGGLVPLGGLGLYERIGLGWGNTLLAFLSILFSLPAVAFYKYGERMRQCRVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6J7</accession>
    <name>A0A2I2G6J7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_477117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703804.1">
        <property type="nucleotide sequence ID" value="XM_024853418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6J7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6J7"/>
    <dbReference type="GeneID" id="36561116"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477117"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="949" mass="107029" checksum="189F3CABE3D1F622" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6K4</accession>
    <name>A0A2I2G6K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_448191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703807.1">
        <property type="nucleotide sequence ID" value="XM_024850948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6K4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6K4"/>
    <dbReference type="GeneID" id="36558647"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448191"/>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="291" mass="33129" checksum="E153C3A8B5710A83" modified="2018-02-28" version="1">MVSNNEWVPKEDRLVRDELYKLEMKIRAWARSYSVQSISDLADISDSERSNIMSQIGHCSAETDWGSLMQKMPISSEKIPAIIIQALLAKDVFEKIFADPFFAFPIFGDDGVLPKPSGMRNLYYTMLQIDEAEAHTWRSQTLRLLWNALDPDSKHALQQKLGEFARERALVFLATPGSQFLRELGKAENETKCLHELQVLFNDATELSLSLWTHRAFMAVRSQRDLPVFTVSSSVMSAHRLHQLDEDDQRLDGSKVLLVVQPAVLACGDENAESYHQWKTWTPANVLVDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6M1</accession>
    <name>A0A2I2G6M1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_477141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703830.1">
        <property type="nucleotide sequence ID" value="XM_024853422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6M1"/>
    <dbReference type="GeneID" id="36561120"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477141"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="223"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="386" mass="43059" checksum="9C66365CFF5C511C" modified="2018-02-28" version="1">MDSIVAQVHSLAKNADEAARRSIQTALEDLLFEIQDPKYIVYQLLNSPVKLTVVRVSIDINLFKTLANSESPRTVSSLAEQLKVDEDLLGRILRYLASNNLIKQTGVEEFAANQVTQIFTGKGAEAVTSQAFNVVGPVLQVVPPFLAETNYQSISVKTKTPLQKAFNTELSAFEWLAQNPEHMQNAQLAMVSNQASNWARNFKLLDDAVHEFMECSQPSSDRPFLVDVGGGYGHQTGHLKDKHPCLSGHLVLQDMPQVVAQVSGLEGVKVMAQDFFTPQAVQGAPFYYFRRILHDYPDDQCVKILQNIIPVMASDSRILIDETVLPDTNVSWQAVMADLYMMFMMAGKERSEKQWRALADSAGLRVVYIHVHDLSSHSAVLVLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6P0</accession>
    <name>A0A2I2G6P0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CobW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_497980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703854.1">
        <property type="nucleotide sequence ID" value="XM_024854122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6P0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6P0"/>
    <dbReference type="GeneID" id="36561827"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_497980"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="7">
        <location>
            <begin position="311"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="580" mass="65400" checksum="36412273FFCD3AE1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6P4</accession>
    <name>A0A2I2G6P4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_359475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703849.1">
        <property type="nucleotide sequence ID" value="XM_024844359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6P4"/>
    <dbReference type="GeneID" id="36552059"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359475"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="620" mass="68350" checksum="DF5E457FA39DF916" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6Q4</accession>
    <name>A0A2I2G6Q4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_465859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703851.1">
        <property type="nucleotide sequence ID" value="XM_024852363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6Q4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6Q4"/>
    <dbReference type="GeneID" id="36560061"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465859"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF21">
        <property type="entry name" value="LIPASE_THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G02590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="112"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="357" mass="38841" checksum="E999753BA0221937" modified="2018-02-28" version="1">MLSLAEKLDFVPALLSVILTVAWAIVSGLWRSSAHPPTFLLHVGYAAFRKATARLSVAQMQAVLPPSNRIYERYVRRSRIAPDTVTLPHGALGHWIGSRKASSASSTDVKVLVWFHGGGFALPANIGYFHFFERLIADAQRTGKSLAVFSLTYTLAPQATYPTQLRQAVEAVRYVLDQDYAPAQILLGGDSAGGNLVGGVLSHLAHTHPAIAPVLLPNDAPLAGAVMIAPWVSMNTDYTGEEIDSRGDLITPAVAGPWASAYLGTATRDFYTDLSTAPTEWYAKFPVEKVLVCAGGSEILLPIIKEFVEKFSQGFERVEFCIGEREGHVAPIYNLHLGDQTETAQGKRVKSWLREVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G704</accession>
    <name>A0A2I2G704_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_509417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703952.1">
        <property type="nucleotide sequence ID" value="XM_024854671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G704"/>
    <dbReference type="STRING" id="1392250.A0A2I2G704"/>
    <dbReference type="GeneID" id="36562377"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509417"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="330"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="675" mass="75103" checksum="452851B3EF80DF42" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G760</accession>
    <name>A0A2I2G760_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_509451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704016.1">
        <property type="nucleotide sequence ID" value="XM_024854679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G760"/>
    <dbReference type="STRING" id="1392250.A0A2I2G760"/>
    <dbReference type="GeneID" id="36562385"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509451"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="4"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="422" mass="47210" checksum="BBD1F35B3854160B" modified="2018-02-28" version="1">MPSAIVTGATGITGSAIVHHLIKDGSYDKIYSFSRRNPGYEHPKIQHVSLDLQGSAEEMAKSLKGISAEYIYFCAYLARDDPDELSRVNAVLLTNFIQALNISGANKSIKRFILTCGFKQYGVHIGQAKQPFLEDDPLPENNAGGVSWPTIFYYEQQRILADAAAKDNWEWVATLPEDVLGYARGNFMNEATSIGLYCAVSKALPGSELPYPGSKANYFTFNCWTSANLHAKFCLWAATAPKAGNNIFNVMNGDTESFQNFWPRLAARFGCKIPDPMFPNGGVPDSKGFKNYEASTIRLPNKPPLKVQGSSLGISSDKEVENPPVLFLQVNPIKWAQRKDVNEAWAKLRDRYHLDQDAWDKATWDFLVMTMGRDWSCVASMSKARKLGWTGYADTWDELEETFQILEKEGVLPPVDQLKRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Z2</accession>
    <name>A0A2I2G7Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_407908</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704302.1">
        <property type="nucleotide sequence ID" value="XM_024846705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Z2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7Z2"/>
    <dbReference type="GeneID" id="36554404"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407908"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="486"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="805"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB49000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="966" mass="107341" checksum="D8765AFD01CD2799" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8K1</accession>
    <name>A0A2I2G8K1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_356520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704507.1">
        <property type="nucleotide sequence ID" value="XM_024844155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8K1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8K1"/>
    <dbReference type="GeneID" id="36551855"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356520"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="309" mass="33271" checksum="B38C871AC3C1C8C4" modified="2018-02-28" version="1">MAAIHQVPQAGLHHDPYRLPPPPPQAGPYRAPDLYAQGPATHTQVVYQAAAPRQRTAIACRYCRRRKIRCSGFESSQDGRCSNCIRFNQECMFTPVSSQAQAFVPAHAAYPHLRNAQTPGRPGAPPVMLYGAHGQPLPPQQQPQAGPDATLPPPQAMYQQPYGAPPLASYSILCPIAKLGTHLFTHQRPPGRRGSGSGYEYPDPTNLAPVTPVTSNPGYSAHTAPSPYYPPQIDRRPSPQSAYPYDSRHSSSPHGSPYPPMHPSQGATPSASTPTSSRGGLNVRDMLNPGDQGRSSTDSSMLNALNRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8X0</accession>
    <name>A0A2I2G8X0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_495176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704634.1">
        <property type="nucleotide sequence ID" value="XM_024854081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8X0"/>
    <dbReference type="GeneID" id="36561786"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_495176"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="235" mass="26686" checksum="B39C498DB7A14D13" modified="2018-02-28" version="1">MPLAISIEAGPTSASHSQFLVFTAHAQVPAQTISHICEVFFMKTRDTRDHTRKKPFHDNAKLQQPASLSWNKMAYGIMDTHPLQCASLIGATFHLLETGGGGCIDRLNQSQGLKTLCHRGEKQKADGDLQEAIAVINTRFDAMPDNAKYQIDCLRIPGYISILWYNMREYVNGLVKAADRYREAVILFPTFCARRLSYFSMSELLHCFNCLESRGRYYEVLTTKWTGRTRKGQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G958</accession>
    <name>A0A2I2G958_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_182961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704675.1">
        <property type="nucleotide sequence ID" value="XM_024842669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G958"/>
    <dbReference type="GeneID" id="36550367"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_182961"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="189" mass="20923" checksum="F6F55925E9676CB8" modified="2018-02-28" version="1">MREFSMHWPVSTRVGGVALGTDGEGKGSPRGIDKHVLALLCLPSSGLSLLPVSLNPTRKKNKKRKRFDPNRKSDNSVIIMRHHRRTAAAEARRGHELHPEPANDTARQVTVERRLEGQTRSGHRGGHTYRNLVRTNPPGILGLSALGEVYAVGVGVPVLRTIVLIRLSCLVGRVLGRIHRTLFPFFFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G981</accession>
    <name>A0A2I2G981_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconate transport-inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_358837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704748.1">
        <property type="nucleotide sequence ID" value="XM_024844318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G981"/>
    <dbReference type="GeneID" id="36552018"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358837"/>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="473" mass="51870" checksum="1BFA7839CCC84FFC" modified="2018-02-28" version="1">MVNGTPSMLEPTYYGYVATTQDALILFEACLTGVLHHVPRRPHDRERAQLVRSGTVFIYEENSSGIKRWTDGVTWSPSRILGNFLVYRELEKPFPPGEKKRAMKKANRRPVPPTRPGEPYPRHDSNAHAFSPPTTGAFGERSQQSDMERALVGSLVDSYGFKDSGLVKKTMSVTVSGVTHHLVSYYSVNDVVHGNLSPPSIHNELRFVRPRMELTQKQSFRAPIDDLETGTLENPNDPSHALYGYRTQMVAPPGYGIPNAHPDFYMQPAPYTATHPPQSAPITGYSMVGTLPSVQAPNSYLPTPTPPTQIPHKPDDYPHFRAPTQYSTGFDPLGQNPLSSSIPSGINTAMSSSLSDRNRSQSDHSPSAYRSSISSRSVATEATSPIDPSTPATFSRGGSFSLASQLDASSHPSFDQRSMAAFDSSIPRRESNTIPTPYYGDRSQYYVNATNPAAHATYPVSTWTTAAPAQPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9A7</accession>
    <name>A0A2I2G9A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MOZ protein represents a chromatin-associated acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_408660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704725.1">
        <property type="nucleotide sequence ID" value="XM_024846740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9A7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9A7"/>
    <dbReference type="GeneID" id="36554439"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408660"/>
    <dbReference type="OrthoDB" id="5424147at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48781" checksum="E9A01412EB1A593F" modified="2018-02-28" version="1">MAAPRLPFLYPHLMRSVRSCEPTTYRSIRIPSSHPSSQKAPFHSSRRRAQETSYNRRYGPAAEANLPPPTRPKDEARHPPTPPVPKDKSNTSPHTPSPPEKVLSEDAKSDAMDTSSRSKSSSSAESNDKKTPEELDPREESESDDRDASASPNLGENPQQERQSKPSQSVPFEGNPLDGVLHMPSPSSYLTPSGLPSSGEQHPHLTPAPYVHHFDTYSLVRDLSTGDFSNDQSVTIMKAVRRILQNNLDFARTNLTSKSDVENESYLFQAACSELQSSLETARNSEMQRQRASRTQLQHESDILSQRLNQELAGLKDDIKGMFNDHKMTTREQQRSIDTSVQELNYKITVSLNSDGKSEIEGLRWILTRRAALAVATSAFMIILFLKYYSVQKTHDGVEKKKEVPVKKKTVEKVIVQDPAVEAVHPVPEPHLGESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9I8</accession>
    <name>A0A2I2G9I8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_408961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704848.1">
        <property type="nucleotide sequence ID" value="XM_024846753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9I8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9I8"/>
    <dbReference type="GeneID" id="36554452"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_408961"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="7">
        <location>
            <begin position="38"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="198" mass="22800" checksum="5CE2D9215A3C7694" modified="2018-02-28" version="1">MADRLDGLSQKTRLPRSVQAVYLRPLRKQAEYGLPVCDLQLRSYSVRNVEFFADFAMRAAYYLKLPVSGPVPLPRITERWTFPRSNFVHKKSQENFERITLRRLLQVKDGDPHVVQVWLAFLRKHAFYGVGMKANVWEHESLDIVKDMDRRVSAVEESLEPHLSAFGQRDKAGHGNISDVLGNQQLTRTGPLTEVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9U7</accession>
    <name>A0A2I2G9U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_465021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704954.1">
        <property type="nucleotide sequence ID" value="XM_024852290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9U7"/>
    <dbReference type="GeneID" id="36559988"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465021"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18256" checksum="C72D7365AB9844E2" modified="2018-02-28" version="1">MSEKIVLPSIAEIEASTDLLSDPSRSVKVVRVRERFAVKVGTSIAPLEAENMKAKGVAALREPIHRTLSGHKNVFTHADLQPKNVMVEQKGVCEDGSPDYQITLLDWALAGWYPEYWDYCNSTVYCQGKHEWLELVPDIFDEYPVEYLMMRIFYTSMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GA41</accession>
    <name>A0A2I2GA41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_357555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705046.1">
        <property type="nucleotide sequence ID" value="XM_024844224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GA41"/>
    <dbReference type="GeneID" id="36551924"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357555"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="271" mass="29324" checksum="4B7766110EE028A1" modified="2018-02-28" version="1">MPSYAITGASRGIGWEFLRQISSDPNNVVIGIVRDKATTERKVLQELPGRPNIHILQADLVDYAALKAASADTARITGGGLDYLIANAGLISQFDAYDPIGVLGQQPEALQQNLLEYFNINVVGNIHLFNLFTPLILKGDAKKVIALSTGQADLDIIPKLNIDLCPAYAISKAGLNTAVAKFSAQYAKDGVLFMSICPGMVETGHFAKANEEQMKGLMRMLGSFKEYAPYIEGPATPEESVKDVLYVMDNASVEKGHGGSFLSHHGNKQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAJ3</accession>
    <name>A0A2I2GAJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_463257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705196.1">
        <property type="nucleotide sequence ID" value="XM_024852158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAJ3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAJ3"/>
    <dbReference type="GeneID" id="36559856"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463257"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014114258" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="164"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="545" mass="58400" checksum="B36064A01863ACEC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAJ9</accession>
    <name>A0A2I2GAJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_473487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705205.1">
        <property type="nucleotide sequence ID" value="XM_024853046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAJ9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAJ9"/>
    <dbReference type="GeneID" id="36560744"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473487"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB49903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="564" mass="61281" checksum="68082B05A79B863B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAR4</accession>
    <name>A0A2I2GAR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_445376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705259.1">
        <property type="nucleotide sequence ID" value="XM_024850700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAR4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAR4"/>
    <dbReference type="GeneID" id="36558399"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445376"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43263" checksum="AEAE8946405F490A" modified="2018-02-28" version="1">MPPTLRHSVCWALRSQLSRPSSPPFLSAPSLASRIQPANSATISTATKMNSVLRLENEPHAYTSGRWVFIFTLDNAKIIIVKLLFRLAGPAKLTTLSEVATILDYNHDARDGTNTVGSEYIIMEHATRVPLREKWYEMAGDRQVRCIDAIYRTMREIVDLEFLAFGSIYFDDTLDSASKHLLGDGFCIGPHCATRYWGTGAGKRRYYYHAKANQGPWLSIDQYCEGFIDAGLSRVPPVDTEPERKPIYHGLSKTHLALLERTCSVLKRMAIDTRISNSATPLLFYPDLHMRNIFVLEDDFSTITTFWYFNEVPDLATGSKKDSTVALRHKQLRTNLSGLLNIASAGWELFDAILEAVLTNANPDGEEPVKDEKALRSIWPFDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAT4</accession>
    <name>A0A2I2GAT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_354701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705279.1">
        <property type="nucleotide sequence ID" value="XM_024844050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAT4"/>
    <dbReference type="GeneID" id="36551750"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354701"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="247" mass="27366" checksum="BB2AC4C4B30207A7" modified="2018-02-28" version="1">MDSQNTNFCFPMKDLENEVVKVIPFDATKHAAAFFEATHPHPELWQYMSIGPFATVAEFIETFLNPVQSSPDQICLAIINKQAAPSPHHPDGQLAGLVTCTGASVAHRTVDLNYTIIFPAFSRQGIPTNASGLLVHYFLRSPAEGGLGLLRVQSRASAGNIASIVAMLRYGFRKEGISRWHRVLHHATQRMKVGNGRLVPGYADRDSVARDTVHLAFCWDDWQNGGREKAERVMERAARSSLLKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB55</accession>
    <name>A0A2I2GB55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_445489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705410.1">
        <property type="nucleotide sequence ID" value="XM_024850716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB55"/>
    <dbReference type="STRING" id="1392250.A0A2I2GB55"/>
    <dbReference type="GeneID" id="36558415"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445489"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="9">
        <location>
            <begin position="392"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="717" mass="79811" checksum="5E9E397EE72431A5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBK5</accession>
    <name>A0A2I2GBK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_380715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705529.1">
        <property type="nucleotide sequence ID" value="XM_024845542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBK5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBK5"/>
    <dbReference type="GeneID" id="36553241"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_380715"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="55713" checksum="A1E2C1A33DB30AAF" modified="2018-02-28" version="1">MPSSSTSSSNWDFTPVINLLRSPTYSDGYQSSLSRHHESRRSPSTSGSSTPKNTVTHLGLQPTDGAHHGDTSPKLGDFSTLWNALGPYTTTPVKAEVAASGEPPAPKVAAGQQSQRPPRIEILKRPTQEKDVGSVNDELPRTPPKPIPGSGATKAGKSTVRSSKTKQPPQIVNPIESSSPGSSAEADSDVSIFDPCFSGRKGALSLVPPQVGAPPTINPCETPPSSYDERDEDLTPKGVKNVPSCGSIRVQPLAYKSSPERRVGLLTKLINSFPEYAETVAQLGRSANSSRTTQASRPIHVFIDMSNIMVGFHDSVKVSRNIPVTTRIRRVPLSFQNFSLILERGRPASKRVLVGSDRFAAIDEGEKLGYEANILDRVQKVKQPTRRQLRFRKNPRGAQDGSGSETNDVPPGRWVEQAVDEILHLKILESLLDTDEPATIVLATGDAAEAEFSGGFMRMVERALQRGWNVELVSFSQVTSYAYRKKEFRAKWGDRFKLIALDGYIEELMAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBV9</accession>
    <name>A0A2I2GBV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_435572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705676.1">
        <property type="nucleotide sequence ID" value="XM_024848967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBV9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBV9"/>
    <dbReference type="GeneID" id="36556666"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435572"/>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="704" mass="78566" checksum="698D9B612A72CD48" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCS7</accession>
    <name>A0A2I2GCS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_151538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705990.1">
        <property type="nucleotide sequence ID" value="XM_024842520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCS7"/>
    <dbReference type="GeneID" id="36550217"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_151538"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="101" mass="10980" checksum="2985E7FF13D67565" modified="2018-02-28" version="1">MGNRAGSSFPIILPRLSRLGRTHRQRHMAFAAASSSIFGSAVSSQSRIVEVSKPQRLQILRRREDTASTGTGTSCPAAFCTHRRVPIPPGTNNKQQTGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCV2</accession>
    <name>A0A2I2GCV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_406070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705994.1">
        <property type="nucleotide sequence ID" value="XM_024846609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCV2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCV2"/>
    <dbReference type="GeneID" id="36554308"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_406070"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="61"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="463" mass="49993" checksum="2787093F69B746CB" modified="2018-02-28" version="1">MSPPQIVSVPSNTIDPENVKEKGLPADQASIGMDEKKLETPPYMQDAFGDEEFAEVKYKVLKWWQCGLLMVAETVSLGVLSLPAAVAGLGLVPAVIILIGLGILATYTGYVIGQFKWRYPHISNMADAGEVLAGKFGRELLGIGQMLFLVFIMASHLLTFTIAMNKITNHGTCSIVFGVVGMIVSFICSLPRTLAKMSWLSLVSFISILSAVFIAMIGVGILHPGDRVDAVVDTNLYNGFTAVTNIVFAFSGHAAFFGLAAELKDPRDFPKALCLLQGVDLCLYLIAAVVIYRFGGADVASPALGSASPVVTKVAYGIALPTIIIAGVINGHIAFKYVYIRIFRGTDRMHKRDWLAISSWVGIGLFLWILAWIIAEAIPVFSNLLSLITALFASWFTYGLSGMFWLYMNKGIWFSSPRKIALTFLNIFNVAVGACLCGLGLYVSGKAIHDNPSSASFSCADNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD61</accession>
    <name>A0A2I2GD61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_508936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706130.1">
        <property type="nucleotide sequence ID" value="XM_024854624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD61"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD61"/>
    <dbReference type="GeneID" id="36562330"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508936"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000652">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="596"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="463"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB50828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126186" checksum="4485F09BCA975A84" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD64</accession>
    <name>A0A2I2GD64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_155132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706140.1">
        <property type="nucleotide sequence ID" value="XM_024842537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD64"/>
    <dbReference type="GeneID" id="36550234"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_155132"/>
    <dbReference type="OrthoDB" id="4387630at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014181011" evidence="1">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="167" mass="17392" checksum="31824804741C095A" modified="2018-02-28" version="1">MRFHLPPTLLLTAALSATPALAGQKVAAVWSGSTFSTVGKTGTNNFGSGFTLLNSDRDGIYNDGTPDGHIPCTFAGKEFQLEKGCLGGAWYSFRWVASQIGIPQSCEVIGPDGESVGKGDGNGDTEFFGVGIALTGACSVEFELVDGLGCGADVDGFVAHHTGWNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEH9</accession>
    <name>A0A2I2GEH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_464240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706601.1">
        <property type="nucleotide sequence ID" value="XM_024852229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEH9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEH9"/>
    <dbReference type="GeneID" id="36559927"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464240"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014112858" evidence="10">
        <location>
            <begin position="20"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB51299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="480" mass="54335" checksum="B66F491B92D938CA" modified="2018-02-28" version="1">MAILLLLTVLSILAPITYATHNLYFHPLAHHPGPLLWRAFRLPFTLSMIRGELPHRIRALHEQYGDVVRVAPNELSFIDPAAWRDIYTRGRDFVRPDEYKDQPPGKTAENLIACSEAKHAQFRKILAPGFSERYAAEQEPYVQSYIDQLCERLDERADVDVVEWINYVAFDIIGDLTWGSSFGCLDGLAYHPWIQTVSQFKAAIIVGALKFYPLVYAFLMAITPASALSEVMQMWKVTEEKVRRRVASGETRPDLVGTMMQSSKEGEGMTGEEMEVNAMMIVAAGSESITTVLTGVINHLLRNPRVHQTLVDILRGTFSSSEDITASSLKNVPYLNAVLNEGMRLCPTIPDAMRRSVPAGGATIAGRFVPGGMVVSVPPWATYRTSRNFTRPNEFAPERWLDDVAFKNDVKTAFNPFSLGPHNCPGQNLAWLELRLILANLLWRYDIYTPPGVELPEWESQGIWWFWDKKPTMVRFSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GET0</accession>
    <name>A0A2I2GET0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_433405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706700.1">
        <property type="nucleotide sequence ID" value="XM_024848485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GET0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GET0"/>
    <dbReference type="GeneID" id="36556184"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433405"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="748" mass="83677" checksum="53187A5AB6665C49" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF19</accession>
    <name>A0A2I2GF19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_506493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706782.1">
        <property type="nucleotide sequence ID" value="XM_024854398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GF19"/>
    <dbReference type="STRING" id="1392250.A0A2I2GF19"/>
    <dbReference type="GeneID" id="36562104"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506493"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB51480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="136" mass="15238" checksum="770D8234F7EA5A94" modified="2018-02-28" version="1">MIVDDGNLLALPRDGFGATRSGDIIEVKPVLRQTKEPQIRIQESHRIVASLLTDFKSSFPTCRSKPRLIISQDRQEIYISVAEHNADYINYLQTGDIRNSPFVVIRQFGPWSTNSATAMAELGPILLAISINAQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGS5</accession>
    <name>A0A2I2GGS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_96281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707383.1">
        <property type="nucleotide sequence ID" value="XM_024855457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGS5"/>
    <dbReference type="GeneID" id="36563164"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_96281"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="80" mass="9324" checksum="1ED774D726058CCF" modified="2018-02-28" version="1">MSWELQAAEEPSQLTIMFRFLLGLLFSALREAFFPSTLFRWSNTNRPDEDFAPITHRVHLHHVNHFADTANAVLNLSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGT7</accession>
    <name>A0A2I2GGT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_462142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707397.1">
        <property type="nucleotide sequence ID" value="XM_024852082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGT7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGT7"/>
    <dbReference type="GeneID" id="36559780"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462142"/>
    <dbReference type="OrthoDB" id="5421247at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24279" checksum="0186A2CC107BB5DB" modified="2018-02-28" version="1">MDPNNHPLHYAHLKTAVETLITAVHSFQQKNPDKEIRIAIIGGLAVRHYIGATRETMDADVLITGVDTTECIKRSLQSQVIFPCAGDEIQVAVRGTFKKVDLIPERVLRPFPTTPTEFVPTSAVPIQSLVQPGHIPYLDEVELLLTKILSCLARSCPRKRRVDARDIDDLARHLTPTGTMTVTLTPIQTQVMVSGLPEFVQYSAFSLLWWRQTFSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHF0</accession>
    <name>A0A2I2GHF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_462293</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707608.1">
        <property type="nucleotide sequence ID" value="XM_024852093.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GHF0"/>
    <dbReference type="GeneID" id="36559791"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462293"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="850"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="906"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="986"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1099"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="340"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="553"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="863"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1299"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1299"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB52306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1442" mass="159093" checksum="359002670684947C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI39</accession>
    <name>A0A2I2GI39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular developmental signal biosynthesis protein FluG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_402779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707836.1">
        <property type="nucleotide sequence ID" value="XM_024846443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI39"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI39"/>
    <dbReference type="GeneID" id="36554142"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402779"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000013">
        <property type="entry name" value="Related to fluG protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="3">
        <location>
            <begin position="431"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="532"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="855" mass="95252" checksum="3A5A12956493AF14" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GI55</accession>
    <name>A0A2I2GI55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_402845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707865.1">
        <property type="nucleotide sequence ID" value="XM_024846449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GI55"/>
    <dbReference type="STRING" id="1392250.A0A2I2GI55"/>
    <dbReference type="GeneID" id="36554148"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_402845"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF8">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29697" checksum="19086FDC2A27C521" modified="2018-02-28" version="1">MDRLEHWLYGTLPPSLHRHQPMKVLALGMGRSGTDSLSKALSTLGYNRVYHGFDMGMTDPPSWEAWVKLARRKWKGNSSSKGSQGDSDITISDLDCILGDCTAATGSPVAIMALEMVQAYPNAKVILNMRDSGKWVQSAKSTFGVVNAGFKYRVLPYFDAQLYWRKRYYEEMVQAYFYGSLENNGKWVYEQHCAKIRGLVPQSQLLEWRAEDGWEPLCRFVYFSLRLYPVWCSTNRLADSWKRIFQTRTFLVEINQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIH3</accession>
    <name>A0A2I2GIH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_403100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707986.1">
        <property type="nucleotide sequence ID" value="XM_024846460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIH3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIH3"/>
    <dbReference type="GeneID" id="36554159"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403100"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB52684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="502" mass="54255" checksum="A959C1EF478226E6" modified="2018-02-28" version="1">MTSKLAQNFKQPALDFLSFVNASPTPFHAVQSAKELLAKAGFQELKEKDSWASTCRPGGKYYLTRNSSTIVAFAVGKKWKPGNSISMIGAHTDSPVLRIKPVSNKRGEGFVQVGVETYGGGIWHTWFDRDLGVAGRAMVRTGDGSIVQKLIKIDRPILRIPTLAIHLDRQETFSFNKETQLFPIAGLVSAELNRTGAASGTSNGTGDKDAKAGEEEKGEFSPLKAITERHHPYIVELIAAEAGVKPLDIIDFEMILFDTQKSALGGLLEEFIFSPRLDNLNSSFCATVGLIDSVADASALDDEPSIRLIALFDHEEIGSRTAQGADSNVLPAIIRRLSVLPASTPDNADLSTAYEETLSTSFLLSADMAHAVHPNYTGKYESDHRPEINKGPVIKINANARYATNSPGIVLLQEVARKAAEGGGEGVPLQLFVVRNDSSCGSTIGPMLSAALGTRTLDLGNPQLSMHSIRETGGTHDVAHSIRLFTSFFQHYSKTSQTIFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ74</accession>
    <name>A0A2I2GJ74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_434654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708237.1">
        <property type="nucleotide sequence ID" value="XM_024848758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ74"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ74"/>
    <dbReference type="GeneID" id="36556457"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434654"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="250" mass="28486" checksum="6F8676A638836BCE" modified="2018-02-28" version="1">MSRPDLTLYTSQTPNGIKISIALEELGLPYKVEKIDISKNTQKEPWFLEINPNGRIPALTDTFTDGQKIRLFESGSILTYLAEQYDKDYKISYPKGTREYYETISWLYFQNAGVGPMQGQANHFSRYAPERIEYGVNRYVNETRRLYSVLDQHLSTSKSGYLVGDHITIADISHWGWVAAAGWAGVDIDEFPNLKAWEERLAAREGVEKGRHVPSPHTVKDLLKNKAQMEKAAAESRAWIQDSMKADAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJD9</accession>
    <name>A0A2I2GJD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_120153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708290.1">
        <property type="nucleotide sequence ID" value="XM_024842357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJD9"/>
    <dbReference type="GeneID" id="36550052"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_120153"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="87" mass="9401" checksum="F0CDA2140B898117" modified="2018-02-28" version="1">MSFGVGPHEWQGGEERKQRSSDPRRQIGNEGGEGWKGPGPQRRASRATGPNGPANGRRASRRDGRGGRRLQETGEATHPDVKGLAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJL7</accession>
    <name>A0A2I2GJL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_434793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708373.1">
        <property type="nucleotide sequence ID" value="XM_024848801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJL7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJL7"/>
    <dbReference type="GeneID" id="36556500"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434793"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB53071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="653" mass="73569" checksum="74388C1D02743CFB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK39</accession>
    <name>A0A2I2GK39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_350419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708542.1">
        <property type="nucleotide sequence ID" value="XM_024843801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK39"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK39"/>
    <dbReference type="GeneID" id="36551501"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_350419"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="71" mass="7903" checksum="38DFC61F7CD7209E" modified="2018-02-28" version="1">MITVYVNDRLGTRAAIPCLASDPIKLFKAQVAARIGRDTHEILLKRQGERPFKDFLTLADYSVSNGAQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKC7</accession>
    <name>A0A2I2GKC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_463048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708611.1">
        <property type="nucleotide sequence ID" value="XM_024852134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKC7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKC7"/>
    <dbReference type="GeneID" id="36559832"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463048"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="465" mass="48847" checksum="D84912241173E2E3" modified="2018-02-28" version="1">MDAMLLWVRQATGASDTPKNSTDTTNNGENPDGKGDTAGGSGEDAHGGAPGGGGGSSSIPNISSATSIQTGVSDPSGVPTTSGSQSENPVDSPNPVTSNWATGSRANSTTSAAQTSSTSRPSSLASPSSTPGTQNASSGLSGGGLAGAIVGSILGTFILTLLGAFLFFRRRRKNKSYAESTGMKSSESTKGLGQISSQPVRSSQPSVKGHGSHSRPVGKQYLNLSSYIPQPADDGTVSSRIQTLFDQASLHIDNYYSSSQTRIRLSQDPVAGFEHYDSAALPAPLATMLAKPRAERAILTHVLVRTLLQAIQPGQQTERLLPAPYVLGPRVSTENNNTRAVFAWRMLTAHLHKAGQPGQETTTVSVSENTIQSLAQDFSTTFASYSDPHFPESDRLAQLSSVFRAASELGTWLFSQPCSFDFRWDTSSVSSDHVIVLPAVVKISDELGQRLPAPRVLVDKTVARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKL4</accession>
    <name>A0A2I2GKL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_348880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708722.1">
        <property type="nucleotide sequence ID" value="XM_024843705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKL4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKL4"/>
    <dbReference type="GeneID" id="36551405"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348880"/>
    <dbReference type="OrthoDB" id="4444391at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151">
        <property type="entry name" value="BLR2777 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151:SF3">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="42"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="396" mass="44502" checksum="238A85C15F67DFD7" modified="2018-02-28" version="1">MSSFFDDKKEPDEITQTPTNTSAKSLSTGDFEKLEKLEILPHILQEGILFAGSGSALLLQAAYPGIKNRISDSQNAQQDSSSALAKELSDALQATLSYIACLVLGTEKEKKTLLDLLQRGQHPIRASETYTSHPPTQLWVSATLYATATDFYQRIYGRVNYRTAEKAYAEFTLLMHALGMPTGTWPATRQAFWKYWDDQIEQLSVTADAHRFAKDLFDRTDLPRWVVMLKPLMRVATIEMLPPRIREAYGLKSTASTRGLYRTAMGFSVAIYPALPKSTRSYALQYYLEDLRKHLNVRIGIIDQALQLVDILARQQLLKILGRVAAQEHRAAFDDSLQIFQRVLAEELLQAVDQLRQLREKTTGGLRSWCGHGVGVGDGQGGSKNEVLEETHFEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLY0</accession>
    <name>A0A2I2GLY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_469365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709182.1">
        <property type="nucleotide sequence ID" value="XM_024852625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLY0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GLY0"/>
    <dbReference type="GeneID" id="36560323"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469365"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="367" mass="40731" checksum="9D335FE84344DF52" modified="2018-02-28" version="1">MPPTDNLQSQAIGLIFGFPAVATVALALRLYSRTLTGTFGADDYVICFAGALYWAETVTSFYVIKYQFIGYHVWDIPENPPTVLGAKFAYMTELLYNPILALVKTSILLFLLRLTGQKTAVRNTIWALLIFNGLAMIATFLVTTFHCYPVAANWNPTAYPNAKCVNFADFVTGTASVSIVTDVLVLMLPTWIVYNLRIRRKQKVLLIGILSFGLITVISGIIRVILLDRYDRHMPEDYTYSVLFCISTIEVGLSFIAACAPSLKPLVMTIIPKMLGTKSQSGDRYNGTYSRNGPGYALEDRSKMSRRTYHGQNTTQIEGGEEAGVSSPSNHSDKTGILMTTEMEVRWYGTRQVNDGSSTESLMQPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM26</accession>
    <name>A0A2I2GM26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_431676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709212.1">
        <property type="nucleotide sequence ID" value="XM_024848094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM26"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM26"/>
    <dbReference type="GeneID" id="36555793"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431676"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="271" mass="30195" checksum="3A17906FFE7AA9AB" modified="2018-02-28" version="1">MSADLLYATGPGPDILSAADPTTDSSPIFFNNPFAPQWLEIPASVEGADQSFESLWPSASWPAKPTRQQPPFDEPTSIQPPAPKRSGRRSGSSRLKSNANKEEREKREKFLERNRMAASKCRQKKRQNTERLQSQFQVAAEKKARLEAEVAQLHGEVLCLKDELLRHSQCDDQAIKNYLQQMVSHVTHQEEPILRTPELSPPSDPLSSSPNTSIATQKSAGFDFDLDGSLDMSDEAKQELETARRDSEQSLLSTTCTLFSDASIEDMVDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMV1</accession>
    <name>A0A2I2GMV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_442327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709498.1">
        <property type="nucleotide sequence ID" value="XM_024850456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMV1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMV1"/>
    <dbReference type="GeneID" id="36558155"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442327"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000443">
        <property type="entry name" value="Integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="441" mass="49457" checksum="236E5D0EBD4EA72A" modified="2018-02-28" version="1">MSLVQVLSALSDSAGGSNRLSPRLAYTEGGPTMDIDPLPSAQRKGLIAISIMAILSFIAALILISFITYRLVFWRSNYARYIGYNQYIVLIYNLVLADLQQALAFLICIKWIVEDKIEASSAACFLQGFWLQVGDPSSGLFVLAIAFHTFLLVTMGHKLSHRTFVTGVIGLWVFVAVLVIIPLASHGRYVFIPSGAWCWISEEYEPVRLWTHYIWIFLAEFGTVTLYAIMWFQLRRQIKQSAILGSSHTESLKRLRRVIGYMVIYPIAYIVLSLPLAAGRMATAQGQTPSVAFFCVAGALITSSGLVDVLLYTLTRRNLILESEPSHDRSYNRFVSSKNRKTDNHLTTITADPKNRTDISALRTVRQRDEEEDLDHHVRDGSTDNIVQNTGVELTPMGKVYQHTTIEITHEPAYPSEAEGSDRSSRDSDKGHDQASRMWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMV6</accession>
    <name>A0A2I2GMV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_373020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709530.1">
        <property type="nucleotide sequence ID" value="XM_024845226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMV6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMV6"/>
    <dbReference type="GeneID" id="36552926"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_373020"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="498" mass="54548" checksum="5CBEBA66EFE3CAAB" modified="2018-02-28" version="1">MVSSFCWGCLTRLRPTPPAVIPPISAPKAASFHTSAVRLSVVKKKQSVQGGRFRESNSPRMKRKKPVDRARPPAVGERKALRKRLVLSNPNALEIEGMQDVSAETMVDPRLRGSVLGLPVPMLTQLRAVEAFKPTQGWSIFRRPGTVVRQETLELGRLIDGISDEGENKGKSVKKIVTGVRGSGKSVHLLQAMSMAFTKKWVVFTVPEPQDLVIAHTGYAPLSDETPDLYVQNAATAALLSRTVSANEEVLNGLKVSQNHPALKSAVKPGMTLAEFARLGTQDLAIAWNVFQGLWSELTATSAAPGLEKDFKPRPPMLVTADGLAHWMKDTQYRTTELKPIHAHDFVFVRHFLSLLKPGTEKPTFPNGGLLLYATSASNNPSVYSFDVALKQVEARHAGVKPSASEFPQADPYSGADQRVIDAFDSPKPTVAKEEMLELQTLSGLSRDEARGFLEYFARSGILQENINEEWVGEKWSLAGGGVIGELEKLGRRLRTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNA3</accession>
    <name>A0A2I2GNA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_442478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709673.1">
        <property type="nucleotide sequence ID" value="XM_024850466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNA3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNA3"/>
    <dbReference type="GeneID" id="36558165"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442478"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF42">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="215"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="456" mass="51385" checksum="E25E4B3366EFE42B" modified="2018-02-28" version="1">MGESKRDVAVVGTGMAGLVTAYLLHHDPQQRFRVHLLDKSPRVSLSAESIAIPSTHPVSKKSAWADIPMRAFAGGYYHNLLRMYDHLGIHYRPQPFVFSFSRRSAHQSHAVVPYMVHASNFHQTPPIPRGDLVRWIWEAIYVLFFYWWFVLCCFFVRPLVFGDMEGESFDHYVRRIHLPLYYVDSYLLPMMSSVCTCSHVELRRFPASDIIAYKRLIHQQPHFVVPDGVYTVQEKLLRGLDVRLGVETIEVLPTSHGVQLTLRDATRVCTQLFDLVILAVSPDVAAAIFRAARPSLRDVPTTTVQTVAHTDFSTVVARLQDGVTMPPDSCSPQMICFCSNGLTTEAIHAQPNGILITTNPLMPIDPTTIIRSAVFTRVLRTPTSQRILREIFREDGSADTESQRDAFVDGSKRWRSGDDGVYLAGGWCWDGMVLLEGCVVSAMRVAADLDVEIPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNN5</accession>
    <name>A0A2I2GNN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_432122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709782.1">
        <property type="nucleotide sequence ID" value="XM_024848193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNN5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNN5"/>
    <dbReference type="GeneID" id="36555892"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_432122"/>
    <dbReference type="OrthoDB" id="5426872at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="165" mass="17559" checksum="0FEEEE83CB87366B" modified="2018-02-28" version="1">MATAPSALPPTTIHSSTPISQSAAHDFLAAYLDRANTDPALQPNAGISEHGPVSRTTAAAPNLILHNLKRVQAGLAGEVLGRDLSIIGDEGTVQPPTAENGDWQDAKKFEQEATGDEQQDSMEVDAVQQDLNEDDAAGGLDKEERKRKKKERRLAEKKAKANAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP05</accession>
    <name>A0A2I2GP05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_398273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709910.1">
        <property type="nucleotide sequence ID" value="XM_024846219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP05"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP05"/>
    <dbReference type="GeneID" id="36553918"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398273"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="195"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="884"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="909"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1109"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="966"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB54608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1135" mass="124083" checksum="40C67E2A3131D405" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP62</accession>
    <name>A0A2I2GP62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_373977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709955.1">
        <property type="nucleotide sequence ID" value="XM_024845266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP62"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP62"/>
    <dbReference type="GeneID" id="36552966"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_373977"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF110">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="309" mass="35188" checksum="CDC61D58FBDCA365" modified="2018-02-28" version="1" fragment="single">MGKPSPSPQRLLTEAIAFGSIAIALYIFRMISRIIASGSINHLGLDDYVMTATIIIYTSMLVLIQISAQYATNLMDPSEYDQVLASPQEVDNRIFGSKIVIGLEQCMLFSTWGVKICMLTLFWRLTKNLRLHIYVQIIAAYVAIGFIVIMITYYAVYCRPFSQYWAMPVHNMQCATYQYYSITQAVFNISSDVAMLVVPIPLLIKAQLRKRRKITLFCVMSLGLFTIVSAILNKAFNFALPLTTIYQIWYIREASTAIYVANLICLWPLLRRLFGFSAFQNSSRQYRQQADRPNREILGALRAPSITMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP68</accession>
    <name>A0A2I2GP68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High-affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_470121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709974.1">
        <property type="nucleotide sequence ID" value="XM_024852714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP68"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP68"/>
    <dbReference type="GeneID" id="36560412"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470121"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="541" mass="59095" checksum="E1D920BA095A65DD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPW9</accession>
    <name>A0A2I2GPW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucoamylase</fullName>
            <ecNumber evidence="10">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_398694</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710222.1">
        <property type="nucleotide sequence ID" value="XM_024846241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPW9"/>
    <dbReference type="SMR" id="A0A2I2GPW9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPW9"/>
    <dbReference type="GeneID" id="36553940"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_398694"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014169810" description="Glucoamylase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="15">
        <location>
            <begin position="524"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB54920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="638" mass="69852" checksum="F0F4ED62927938D1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPY2</accession>
    <name>A0A2I2GPY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha and gamma adaptin binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_505574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710235.1">
        <property type="nucleotide sequence ID" value="XM_024854299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPY2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPY2"/>
    <dbReference type="GeneID" id="36562005"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505574"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47603" checksum="8F28D13D1238EAA9" modified="2018-02-28" version="1">MPTTTDHPHQQRIPNPRRLLILSPSSHSPTTIPPFLHALTGTPVLEPPSTAPANPSAPSFAGYTTHPPLQIRNKYYVAEVPVWVDEIALETDTRGLKNEGEKTQSESESESTLVPSMSTSTLDTGAEPAPATATEPKQGQEQEPLTTPSLWKSEFSGPEAQVVRDAVGAVVMCILNPDPSKRASSASGPETETEETQSLKDFLRAIGDVRALIEEERGGMGDVPGLVVLVGPQGKAATQTQSQSQNTDTDTGLGMDMDVGEDADEPFSIPWWEDQLYEMGMIGMEVVSWDPKGGKEMEEVRNQFGEYQGMRRIREILETHDWAPSSLSDDEEDKDDPEGDDIEKMLLGAEDDTGFGLEVDELEREMVGLRFAIERGGGSGREDSQDEGDDELRVDAVEALMLRMAAIRDMSDDLPEHERKRFAAKAVRDIMKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQM3</accession>
    <name>A0A2I2GQM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_443026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710456.1">
        <property type="nucleotide sequence ID" value="XM_024850503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQM3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQM3"/>
    <dbReference type="GeneID" id="36558202"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443026"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="311" mass="33568" checksum="DB983A1F49129ECF" modified="2018-02-28" version="1">MHILVVNDDGPPCSQLSPYIRPFVNALQDAGHLVSVAIPAASRSWIGKAHLIEASLKATYVPPAAFRNDATWDEAFDADADADTVQDPHGDWVVIRNGTPASCVQLGLFNLFADRGPIDLVISGPNHGRNASTIYNLSSGTVGGALEAATCGKRGIAISFGSKDPQPADTIAAASRLAVRLVDHLSRRWDERVELYNLNIPMRTDVESRSIQYTRALPYYWARGYLYAEEPTAQKTNGATNGALTNGAAPSRLKQRNFNWSAELSDMKKALQSSEEGTDAHTVLNGNVSVTALCANFWHVPGLDGPLELDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQX8</accession>
    <name>A0A2I2GQX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylacetamide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_443124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710591.1">
        <property type="nucleotide sequence ID" value="XM_024850511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQX8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQX8"/>
    <dbReference type="GeneID" id="36558210"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443124"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014162878" evidence="5">
        <location>
            <begin position="19"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="6">
        <location>
            <begin position="150"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="6">
        <location>
            <begin position="356"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="674"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="859"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="913" mass="100502" checksum="6F0437F29D73B293" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQY4</accession>
    <name>A0A2I2GQY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_470714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710597.1">
        <property type="nucleotide sequence ID" value="XM_024852781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQY4"/>
    <dbReference type="GeneID" id="36560479"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470714"/>
    <dbReference type="OrthoDB" id="5387413at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="207" mass="24038" checksum="8C7B7ED723A2A1B6" modified="2018-02-28" version="1">MPAPIIQNISEPVVPVRELEVDEEYVMTNFERHASHCYQCADPLQVHQEDRSLCDRGHQYALDVADYIYSKNGKAYSVVGRETNQPTMVRIPRNSVAVRGLLLAIEDGLRLHRRERQQVQTAAPVISYDRTYLVPPRRRVTQPAPQQPAYNEIIEREPRTPKRRRVIVYPSPRSSPSRGSLYEADAADRVERFKESSRIYRPAEYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR42</accession>
    <name>A0A2I2GR42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_443162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710650.1">
        <property type="nucleotide sequence ID" value="XM_024850512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR42"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR42"/>
    <dbReference type="GeneID" id="36558211"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443162"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB55348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="524" mass="56724" checksum="16C64C1E6BCF8A23" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRV4</accession>
    <name>A0A2I2GRV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_375469</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710919.1">
        <property type="nucleotide sequence ID" value="XM_024845317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRV4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRV4"/>
    <dbReference type="GeneID" id="36553017"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_375469"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="102"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB55617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="775" mass="85144" checksum="74AC6D253ED33BDB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSE0</accession>
    <name>A0A2I2GSE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_471199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711103.1">
        <property type="nucleotide sequence ID" value="XM_024852818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSE0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSE0"/>
    <dbReference type="GeneID" id="36560516"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_471199"/>
    <dbReference type="OrthoDB" id="3595619at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="423" mass="46819" checksum="94BCEB089B0F23FD" modified="2018-02-28" version="1">MTDIICLAGAEREMKVCHTQPHLVPPMKLADDPPSSSMPSWVVDGRNLASRASSRASMSFRRKSMATTSLRISAPSEFRRVPTFYMTPERASFHPLELSLGHLPELPNFEEFRLEDDNSQPPAPVSRPPRAELSRHSRSRSHRPSSSFHLQRKPVGSGSLRSSLATFDHLVEMPPPVPSNTHAPQLSSSSTVTGLTSNVFAPTQQLDPTPPVKEESIRDPPSEPPSVPRTPTLQDRPLTSFLDDSSSAPSTPREAHPPRTPSETMTSPNINVTITPPRSSRVTQWLLQTSNKSMFSPSGSISNWKPTPDKNPFRLRSRTLSGSTVASSISSLTGSLGFKTTTPSESDNITATTIRPSNTDSRLEKELEFPLPRANIDQNQNHYHDYNAHPTIHESQGPQQDNGENYPYNYYENYRHSAVGLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSG3</accession>
    <name>A0A2I2GSG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_506321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711108.1">
        <property type="nucleotide sequence ID" value="XM_024854381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSG3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSG3"/>
    <dbReference type="GeneID" id="36562087"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506321"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB55806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="274" mass="31184" checksum="8707937FF8CF9468" modified="2018-02-28" version="1">MKHRPAIKQSNNQKLIMIGIFAEVYLVDGEIIRKAPRSHSKEDAEPILREATIYSLIGGHPRIARCLSLGHPDYVDIKYYRHGDLVTYCRENKVSPDLQARWFQQIIEAVIVIHKHGIIHSDLALRQFFVDDDLNIRLGDFNSSQYPGHPALGYEKASHCLPRDYELPNTVTSDLFALGSTLHELVAGSPPYQELYPIETQDVVQSSDHAVIRARVQRQHLADCEVEERFRNQLFPDVSGLRGSDVILGCWRGHFSSAEEALSQYLYLTVQPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQ52</accession>
    <name>A0A2I2FQ52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_514718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000035">
        <property type="protein sequence ID" value="PLB42736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698038.1">
        <property type="nucleotide sequence ID" value="XM_024855244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQ52"/>
    <dbReference type="GeneID" id="36562950"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514718"/>
    <dbReference type="OrthoDB" id="2387577at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB42736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="88" mass="9826" checksum="1A4489E96C3CE38E" modified="2018-02-28" version="1">MSTTWRENYSFPRIFKGRRGRTGPCKGAGLCQPWNPSSGQTDFRDPADVSAFSYVAVENPHPGAGMLTGFPFGTRRTRAPFKRNFPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQU8</accession>
    <name>A0A2I2FQU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Senescence-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P170DRAFT_395084</name>
        <name evidence="23" type="ORF">P170DRAFT_395119</name>
        <name evidence="20" type="ORF">P170DRAFT_395210</name>
        <name evidence="17" type="ORF">P170DRAFT_395299</name>
        <name evidence="15" type="ORF">P170DRAFT_395344</name>
        <name evidence="16" type="ORF">P170DRAFT_395380</name>
        <name evidence="7" type="ORF">P170DRAFT_395707</name>
        <name evidence="4" type="ORF">P170DRAFT_395855</name>
        <name evidence="21" type="ORF">P170DRAFT_419418</name>
        <name evidence="18" type="ORF">P170DRAFT_441832</name>
        <name evidence="19" type="ORF">P170DRAFT_441834</name>
        <name evidence="13" type="ORF">P170DRAFT_441848</name>
        <name evidence="14" type="ORF">P170DRAFT_441850</name>
        <name evidence="11" type="ORF">P170DRAFT_441852</name>
        <name evidence="12" type="ORF">P170DRAFT_441854</name>
        <name evidence="10" type="ORF">P170DRAFT_441856</name>
        <name evidence="9" type="ORF">P170DRAFT_441858</name>
        <name evidence="8" type="ORF">P170DRAFT_441861</name>
        <name evidence="6" type="ORF">P170DRAFT_441864</name>
        <name evidence="5" type="ORF">P170DRAFT_441868</name>
        <name evidence="3" type="ORF">P170DRAFT_441871</name>
        <name evidence="2" type="ORF">P170DRAFT_441880</name>
    </gene>
    <organism evidence="17 24">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 24">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000032">
        <property type="protein sequence ID" value="PLB42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000027">
        <property type="protein sequence ID" value="PLB42789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000025">
        <property type="protein sequence ID" value="PLB42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000024">
        <property type="protein sequence ID" value="PLB42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000023">
        <property type="protein sequence ID" value="PLB42842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000022">
        <property type="protein sequence ID" value="PLB42855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000021">
        <property type="protein sequence ID" value="PLB42877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000020">
        <property type="protein sequence ID" value="PLB42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000019">
        <property type="protein sequence ID" value="PLB42906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000018">
        <property type="protein sequence ID" value="PLB42922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000018">
        <property type="protein sequence ID" value="PLB42930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000017">
        <property type="protein sequence ID" value="PLB42961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000016">
        <property type="protein sequence ID" value="PLB42978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000015">
        <property type="protein sequence ID" value="PLB43008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000014">
        <property type="protein sequence ID" value="PLB43048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000013">
        <property type="protein sequence ID" value="PLB43082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395084"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395119"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395210"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395299"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395344"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395380"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395707"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_395855"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_419418"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441832"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441834"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441848"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441850"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441852"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441854"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441856"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441858"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441861"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441864"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441868"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441871"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441880"/>
    <dbReference type="OrthoDB" id="4378253at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB42789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB42833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB42842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB42877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB42906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB42922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB42930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB42961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB42968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB42978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB43008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB43026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB43035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB43048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB43059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PLB43069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PLB43082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="126" mass="13752" checksum="9C181E2F0B6C8718" modified="2018-02-28" version="1">MIGRADIEGSKSNVAMNAWLPQASYPCGNFSGTSSLKFRGTKGSIGHTFMVCIHTENQNQGDFYPFVLLEISVLHESPLGHLRCGLTDVPPQPNSPPDNVFNPDRPAKDLNARRWAVKPSSASLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRH0</accession>
    <name>A0A2I2FRH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_514496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698532.1">
        <property type="nucleotide sequence ID" value="XM_024855211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRH0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRH0"/>
    <dbReference type="GeneID" id="36562917"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514496"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="344" mass="37218" checksum="6BF9FC13FF4D14E9" modified="2018-02-28" version="1">MKSSMPKDTMTHALWTKIIEDASIQRSSQTLSVLGDDIYIYGGELRPREPVDSAVHRLSVHDTITTSSLTISSLPNPPQPRVGAASTALNGQIYIFSGRGGLAMAPIEETGAFQILDPQRGWSYLKPDNTSPYPQGRSYHALTNNGSDTIYLHAGCPETGRLRDLWAFHVPSRVWTQLPSAPGPERGGSSIAYSDGKIYRMNGFDGAMELGGAVDVFDLAANEWRNISYAADGVKGPIARSVACLLALRVGGRQSLVTMFGERETSDLGHLGAGKMLSDMWVFDIQSEMWRKVVVDSEDRPPARGWFGAGVVGSGAEEGIVVQGGLGESNDRLGDVWMLKFEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRX3</accession>
    <name>A0A2I2FRX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">P170DRAFT_370467</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698658.1">
        <property type="nucleotide sequence ID" value="XM_024844958.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2FRX3"/>
    <dbReference type="GeneID" id="36552658"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_370467"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="839"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="927"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1013"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="68"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PLB43356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1348" mass="147210" checksum="299A97F88149FB92" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FS70</accession>
    <name>A0A2I2FS70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_369680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698776.1">
        <property type="nucleotide sequence ID" value="XM_024844920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FS70"/>
    <dbReference type="STRING" id="1392250.A0A2I2FS70"/>
    <dbReference type="GeneID" id="36552620"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369680"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07650">
        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000102">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="3">
        <location>
            <begin position="582"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="870" mass="94633" checksum="A7F08A634331BFC4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSD9</accession>
    <name>A0A2I2FSD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_368968</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698845.1">
        <property type="nucleotide sequence ID" value="XM_024844883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSD9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSD9"/>
    <dbReference type="GeneID" id="36552583"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368968"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="233"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB43543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="499" mass="56024" checksum="7B7312161F6AD4F2" modified="2018-02-28" version="1">MATKALEAHFRDLSVQDENSGYNKIDPHQKSKASSLRDALVICVECTAADREQIASASTHPSDKTRPTKGPKAEIYKQNCTITEPVTPQAAQENGGRTLRRTRKPLSVISTQKPGEGTITTVNHAISQVPQSKYLQSPSRGRHPLSIVVSQKPDAASEVEKQPNSRDVEGQSPTSHRLAPQVAETKGGRALSRSRNTPFAASSETPDPVVKAEEPSPNLIKQPVPKVFHLGMFEVGRPLGKGKFGRVYLARERQSGFVCALKVLHKDEIRQGRVEKQVAREIEIQSNLRHPNILQLYGHFHDRERIILILEYAGKGELYKHLQKENRFPEWKAAHYIAQMANALQYLHRKHVIHRDIKPENILVGLHGELKMSDFGWSVHAPSGRRQTMCGTLDYLPPEMVDPKKSSKPYDEKVDLWALGVLMYEFLVGSAPFEDTPIMTQRRIARGDMSIPSFVSPEAKDLIKKLLLLDSDLRISVDQIRHHPWIIKHCANTGKQDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSE3</accession>
    <name>A0A2I2FSE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_430588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 7"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698818.1">
        <property type="nucleotide sequence ID" value="XM_024847965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSE3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSE3"/>
    <dbReference type="GeneID" id="36555664"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430588"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000396">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000201">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="10">
        <location>
            <begin position="772"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="888"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="740"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1099"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1128"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB43516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126589" checksum="110D467852F2943F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSQ2</accession>
    <name>A0A2I2FSQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_58653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698938.1">
        <property type="nucleotide sequence ID" value="XM_024855286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSQ2"/>
    <dbReference type="GeneID" id="36562992"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_58653"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="154" mass="17250" checksum="74589CC7049DC3CE" modified="2018-02-28" version="1">MAVGKDQVAAMVDARLWPTGTQRLLSLPSCLGPRSFFVLILGFLVSPLPLFPFHLVSIHHTQTPSGPTSAPYIKRSPNVQHSQQEKEKNPPDKRKKKKYPMKSTFTIEQPSGLSCLCAYISHPPCTLPDLTFDTPHSPDHRLCQHLPSDRLFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSZ5</accession>
    <name>A0A2I2FSZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative quinate pathway repressor protein QutR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_514064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699038.1">
        <property type="nucleotide sequence ID" value="XM_024855167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSZ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSZ5"/>
    <dbReference type="GeneID" id="36562873"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514064"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000019">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002254">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="9">
        <location>
            <begin position="584"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="8">
        <location>
            <begin position="726"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="10">
        <location>
            <begin position="868"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB43736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="925" mass="102977" checksum="E22E6A73BF02004F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FT55</accession>
    <name>A0A2I2FT55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Histone H3 methyltransferase SUV39H1/Clr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_368535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699093.1">
        <property type="nucleotide sequence ID" value="XM_024844864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FT55"/>
    <dbReference type="STRING" id="1392250.A0A2I2FT55"/>
    <dbReference type="GeneID" id="36552564"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368535"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="227"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB43791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="392" mass="44215" checksum="2D75E206BBEE6040" modified="2018-02-28" version="1" fragment="single">PSTPSPGPTSQDQLQSFKVVVPSPSRQLRTEIASAQRITSEVPTGLSEKYYPTDAYEERALKGAYPKSKRVNRAEIPFEIGTPGPFLTSRPEVNLQLQRSLQRKLSAIKGPAVTFAATDQKLLAQFENFEFINSNLLRKGVQPAPDEFHGGCSCAMVCDPSRCTCLETEEDDSKKTIIPYERAKDDARLMVLTPEFMKRNMMISECGSRCDCNAGCWNRVVQSGRRIRLEIFHTDNRGFGLRSPDHIRAGQFIDCYLGEVITKDAADVREELCMARHGHSYLFGLDWFDDTVEEEDMFVIDGQKFGAPTRFMNHSCNPNCRMFPATRNQADQRLYDLAFFSLKDIPPLTELTFDYNPGSEKVDHVDPQAVACLCGESNCRGQLWPNQRKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTA0</accession>
    <name>A0A2I2FTA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_369672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699161.1">
        <property type="nucleotide sequence ID" value="XM_024844918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTA0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTA0"/>
    <dbReference type="GeneID" id="36552618"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369672"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB43859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="61842" checksum="54A5F5044338BC07" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTH7</accession>
    <name>A0A2I2FTH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NEFA-interacting nuclear protein NIP30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_441386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699247.1">
        <property type="nucleotide sequence ID" value="XM_024850296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTH7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTH7"/>
    <dbReference type="GeneID" id="36557995"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441386"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="250" mass="27581" checksum="F28A16EE8692EA56" modified="2018-02-28" version="1">MSSGFVSAGTDQEPVERDDEWLRVQHELEEERKRKADLGKQDGGKSLYDVLQQNKMAKQEAFEEKIKLKNQFRSLDEDEVDFLDSIMESTRAQEAAVKKETSEQLELFRRQREEAEKALLEDTSADVAPAAEGEDWKIPARKRRREKNKELLLPGKKRKSTSEVAGGSSASGESKSAQTTRKPEEAPGSVSAQKATPIETQKSPVESTKTINPAKNTQGAASDQSEKKSEPAAKPPSLSLGLAGYSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU61</accession>
    <name>A0A2I2FU61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_367482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699481.1">
        <property type="nucleotide sequence ID" value="XM_024844809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU61"/>
    <dbReference type="GeneID" id="36552509"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367482"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="49" mass="5780" checksum="C64C2A093E1B283A" modified="2018-02-28" version="1" fragment="single">NIFIDFIIYLPENQSYNTILVIIDYLIKIKYLIPYNLTINTPAIATIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUF8</accession>
    <name>A0A2I2FUF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_467979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699564.1">
        <property type="nucleotide sequence ID" value="XM_024852513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUF8"/>
    <dbReference type="GeneID" id="36560211"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467979"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="165" mass="18379" checksum="107E8EB0A5D16991" modified="2018-02-28" version="1">MSYNAKNLAYEAKEPAFLQKLKGQYGDTSGRLQQPISRPRRPKDDTGDDDAPTYVDEESNEVISKEEYEAMVRGGAPKEEESGEKTADRENPSGGDEDTQYKTEKDGPSSKQNLAEIGGQKKRKQAKVIGEDAPEAETEEAQPKEPAPRKSKQKKKKIKLSFDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUI1</accession>
    <name>A0A2I2FUI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="14">2.4.1.132</ecNumber>
            <ecNumber evidence="14">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_513519</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13 14">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="14"/>
    <dbReference type="EC" id="2.4.1.257" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699610.1">
        <property type="nucleotide sequence ID" value="XM_024855117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUI1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUI1"/>
    <dbReference type="GeneID" id="36562823"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513519"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000240">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="17">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="17">
        <location>
            <begin position="171"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="16">
        <location>
            <begin position="270"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB44308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="511" mass="56146" checksum="50A1317C2C59CC07" modified="2018-02-28" version="1">MPGLPANVIIIHPDLGIGGAERLIIDVALALQSRGHRVTVYTSHRDTSHCFEEARDGTLDVRVRGNTVFPAHLAGRFHVFMAIMRQLHLTASVLGEIREEEEERKRKGKRSGDKSDGKGTTEEEETQARDTIFIVDQVPACVPFLKVLGPRYQLPSQAEAQAQGQGSSLQRILFYCHFPDQLLARRDEGGSLLRLAKVLYRCPFDWFEGWALSASDRVVANSRFTRGVVSDVFGLKSLGDVRVVYPCVDTAAGAGGEVGEKGEGDEKLWGGKKILLSINRFERKKDMALAVRAYHGLGEKRRGTRLVIAGGYDNRVQENVQYHKELDELATGLGLQTATSKTVISALSIPDSIDVLFLLSVPTAFRDTLLLQSKLLLYTPINEHFGIVPVEAMRAGIPVLASNTGGPLETIVEGETGWLRDAKVDADWTAVMDKVLYGMDQTELDRMSAAAKKRVENEFSLTAMGDSLEEEIGEMLGSERRPFGGFQQILVILALSGFALSVLAAMVLRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUK7</accession>
    <name>A0A2I2FUK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_440631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699631.1">
        <property type="nucleotide sequence ID" value="XM_024850127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUK7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUK7"/>
    <dbReference type="GeneID" id="36557826"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440631"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="406" mass="45470" checksum="9D086F8EA1AB6063" modified="2018-02-28" version="1">MARNLDQLPTEILLLIAQCLADQRGINALVQTSRNLYNSLYHFLCLHNVQHEKGSALLFAAQNGYTGLTTKLLDAGLEISSFESLNEVAYDKSRDEDLSRANPLLMSAQAGHNSTLDLMLSEKRPDQACSRAQLRTVLHWAIRSHNKQLVELMIEHQAPLDPAGTEREAPSALGVAVSSRYYSIIPHFLDLGARAGKHECPCPIEQAIYDDQPSLIALLFEHGVRLNCDCGLCYIASRGDTATLQLLIDHGIDLSVYGNAALLYAIMEGQYDMTKLLIDNGASPNYNCRFTIFKEDDLNVFWYDAIDFAVHFERVDILKLLLEKGAHPGYGIRTKDDNYSEEILSLLSKGRKRYSPSQKSLESLAWFGNQIREEDDDLRLNWPGLVCAIDDAYPPFPEAVHRALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUW6</accession>
    <name>A0A2I2FUW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_430313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20366"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699716.1">
        <property type="nucleotide sequence ID" value="XM_024847943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUW6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUW6"/>
    <dbReference type="GeneID" id="36555642"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_430313"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="221" mass="24395" checksum="B9576B582F733049" modified="2018-02-28" version="1">MAESVLYKPDQYDDAYACDPGVLHFLSTVLSHLPPQSQVLDVGCGTGKPVAETLAAAGHFITGIDNVHAMVELSQQRIPNGVFQLSDMRQYVHPTGKQLDAVLMVRSLFRLGREEIEETVRKYGSQLHGGGLICIATMAADDFSPDNILSGYDPDGLCAREVRKRFMGNQVTSALFTRAGWKQLLQKNGFAIVNQKMDVFGPPDRIDSDALPYYYIIAEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUZ6</accession>
    <name>A0A2I2FUZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_450563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699765.1">
        <property type="nucleotide sequence ID" value="XM_024851133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUZ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUZ6"/>
    <dbReference type="GeneID" id="36558832"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_450563"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="186" mass="20892" checksum="55EC16DFB29A8A2E" modified="2018-02-28" version="1">MTTSLNTQQFLSELSITQLLHSSDSSKIFPINHESAKYCLKVFHVNKDPGFTSKGRDLCRWRCEIEAYKLLSAAGACEQGFVPKLHAVFEDIDPLTPTLVPHLNAFLDDVHRPCAGFTPNYTRDRIQKAILGIKAVHHVRVVHNDPYRKNVLIVPGVEGKGGDERVVWVDFDIAQILDETGQQLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVC2</accession>
    <name>A0A2I2FVC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pseudouridine synthase TruD/Pus7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_468236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699892.1">
        <property type="nucleotide sequence ID" value="XM_024852546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVC2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVC2"/>
    <dbReference type="GeneID" id="36560244"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468236"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000009">
        <property type="entry name" value="Pseudouridine synthase TruD/Pus7, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000007">
        <property type="entry name" value="PUS7p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="378"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB44590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="725" mass="80420" checksum="FC7CCC88B4B248FE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVX6</accession>
    <name>A0A2I2FVX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_366652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700092.1">
        <property type="nucleotide sequence ID" value="XM_024844766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVX6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVX6"/>
    <dbReference type="GeneID" id="36552466"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_366652"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="IucA/IucC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384:SF5">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC N-terminal" evidence="1">
        <location>
            <begin position="200"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal" evidence="2">
        <location>
            <begin position="331"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57088" checksum="6DB6D0A3CEA6886E" modified="2018-02-28" version="1">MTRIADYRVQAKAETTKRLIAQLINEELARLTISACGQSEIYEACISKDGDTTRRILLCVRDRNRSLGRPNDFIAPVILDSADLEVKHDDPGTIFDFISSWLDCNEKMKESIVSELRNSAIMLEKWMEYGAKKPMLNLNSPFIEWEQSVVSGHPTHPSLRDLFEIEDISTDKSIIVPCLLQQLPAVQRFFPEAKVIKSVPHCAKAQTSIRTVSVSGFELEKFSLACLITSGFRALACWAAALAVDMTYVLRKLLPSDLWIFGEVAAITGSQEDVSEARHLTCVLRESLEVRAERNDESLILVSALMEKPGNGEATYAEILFDLKTAERKIEWFKGYISCLLPLALDPLRRHGIGCEFHAQNTIVRLCRKTKSIKGFAIRDLSGVRLHGSSLKEQGFDISKFDNVSTEELPMLWNRMHHALIQNNIGFMLYAFGLENNPEGWAAVHSILSDTLESGNDLIGKEIFQHFCKETMPFKCFINMRMNALFNCVSTLPHILNVLLIRETSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW74</accession>
    <name>A0A2I2FW74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_440093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700192.1">
        <property type="nucleotide sequence ID" value="XM_024849990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW74"/>
    <dbReference type="GeneID" id="36557689"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440093"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB44890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="370" mass="41103" checksum="D09A56B365D08138" modified="2018-02-28" version="1">MSNPYNRRSLPDYFISSPLTALLYPFHQCLLRLRGPPRLPPPDARPIRVVCISDTHSLEWADIPDGDLLIHAGDLTNDGSVRDIQAAVDWLRALPHPHKVVVCGNHDSYFDVRSRLAEDRDASSFTAVSSSTASLRSLDELDSPTRIEWGDVHYLQHSSVTLSFPPPSAPSASSTSPLTTTPSRTRSLTLYGAPQVPALMSFGPEHAFTYPPYYDAWSGTVPAATDILITHTPPQSHLDMSPVYSTGCPYLLAEAWRVRPALHVFGHIHHSYGIEPVFWDGAQRAWERLCLSRRRRARYSRSSALFGFLRDLFDLSGWVDATRVLGYGLMGVVWAKVWGGEEMGCGWMVNAACMYGDSGRLANKPQVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWD7</accession>
    <name>A0A2I2FWD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_479489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700252.1">
        <property type="nucleotide sequence ID" value="XM_024853683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWD7"/>
    <dbReference type="GeneID" id="36561381"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479489"/>
    <dbReference type="OrthoDB" id="5365320at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="236" mass="27360" checksum="B3C59718EF34E951" modified="2018-02-28" version="1">MASHISSQTKDGRALTNEDFPPGDIYYLQTFPTELLIKIYCQLGSFSTVYRLGATCRRLQSVWAENTNIIYKSIAPLEIRCHRHARNLLADQGGSAPDAPVSVWDVQRLTRNVCNVNRTMKVFDDEVACHVSKHSISPDPVTWGRRTRPQHLTDTERRRFIRAYYQMWGVLILELEKQNDRMDSISLKDLAVMVDLTEPWSWIRPNVKIGDESILERDPEERNSLHERLHLVLMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWT1</accession>
    <name>A0A2I2FWT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative DNA-directed DNA polymerase theta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_440237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700403.1">
        <property type="nucleotide sequence ID" value="XM_024850032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWT1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWT1"/>
    <dbReference type="GeneID" id="36557731"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440237"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000005">
        <property type="entry name" value="DNA-directed DNA polymerase theta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000968">
        <property type="entry name" value="Helicase and polymerase-containing protein TEBICHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="142"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="425"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="930" mass="102842" checksum="351EEDD057C9B7F7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX25</accession>
    <name>A0A2I2FX25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700490.1">
        <property type="nucleotide sequence ID" value="XM_024850050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX25"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX25"/>
    <dbReference type="GeneID" id="36557749"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440325"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014171253" description="GPI anchored cell wall protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="20577" checksum="9EE64D39A42CC9E9" modified="2018-02-28" version="1">MRTSLLLTAALAGLAIAEDTTTVGYFAADWTSIEIPRYESTAASVAGINAVATTYAVGCLKDAPTSLCHIDKPWTLIQGSETYSLTGVYTAGQTGKEKDNGVTVTRDIQCSFTSFSESAGCSFSYQATGKISGASYSTGTSSSSTFATDQVGYYKMPVTAGLSSFTAPQATETPDAARAVGPARALITAAPLAAAAAVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX59</accession>
    <name>A0A2I2FX59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_274923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700495.1">
        <property type="nucleotide sequence ID" value="XM_024843164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX59"/>
    <dbReference type="GeneID" id="36550863"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_274923"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="142" mass="16439" checksum="354427F78CB72AC0" modified="2018-02-28" version="1">MESDRVSTERCTSRWYLVQVYWRVYICLFSGSFTALFYLHSTILLQPFLLYCMPAGATVTRAAEPYRRPNLLFFFPLFFLPSSPANKSIPTCCIFNPDYSSQGYTTDLLCLCVAPLWFRMIRCQPSYRRRGSANDPKPGTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FX76</accession>
    <name>A0A2I2FX76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_479764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700547.1">
        <property type="nucleotide sequence ID" value="XM_024853715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FX76"/>
    <dbReference type="STRING" id="1392250.A0A2I2FX76"/>
    <dbReference type="GeneID" id="36561413"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_479764"/>
    <dbReference type="OrthoDB" id="5420368at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="218" mass="23929" checksum="18A0A50E143AB0D6" modified="2018-02-28" version="1">MPMKWTPENDQLLLLKILETHDLSVDTKRVADAWPINEDSGKKNDRPTPRAITERLVRMRQIVKSTGTGTSSTDGHFSIGKGTGSAPSTPRKPRASGLKTPSTSGKRKLSGLGDASQNAHRPVEEDDTPTHKKPLHPTLAGMNRNGNPDQVGVTLKLEVDDDEGFVDQLTPSPKRVRKASTLPLGMVSYKEEDDDDLTVESSSEYTPDQVREDDDIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXK8</accession>
    <name>A0A2I2FXK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mov34-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_466708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700670.1">
        <property type="nucleotide sequence ID" value="XM_024852436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXK8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXK8"/>
    <dbReference type="GeneID" id="36560134"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466708"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="359" mass="39983" checksum="CF5E2520EB72796E" modified="2018-02-28" version="1">MPATTADTLSLVQRTVTVAPLVLLSVADHYGRSAKGTRKRVVGVLLGENTGQNVRVSNSFAVPFEEDEKDPSVWFLDHNFVESMRDMFKKINAREKLIGWYHSGPKLRASDLEINELFKRYTPNPLLVIVDVQPKEVGVPTDAYFAVDEIKDDGTTTSKTFVHTPSIIEAEEAEEIGVEHLLRDIRDVAVGTLSTRITSQLQSLQGLHLRLRDIGQYLQKVLDHELPVNHAILGNLQDVFNLLPNLSTPPATQRLSGSEQPTDNSELARAMSIKTNDQLMAIYLSSLIRAITAFHDLIDNKIQNRQQQEENELKREQEANAAKNEKEAAKKGSGAANGEQKENQNGSKDKSKKKSPRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXV3</accession>
    <name>A0A2I2FXV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_457784</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700718.1">
        <property type="nucleotide sequence ID" value="XM_024851741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXV3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXV3"/>
    <dbReference type="GeneID" id="36559440"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457784"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="20">
        <location>
            <begin position="566"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB45416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="803" mass="91337" checksum="50AF71C152B4E2B5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY54</accession>
    <name>A0A2I2FY54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_478509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700854.1">
        <property type="nucleotide sequence ID" value="XM_024853567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY54"/>
    <dbReference type="STRING" id="1392250.A0A2I2FY54"/>
    <dbReference type="GeneID" id="36561265"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478509"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21988" checksum="E537180A9A738988" modified="2018-02-28" version="1">MAPQDTAGRIPKKSFISTSVLLGLTLVGVLVRFLIRFRIQRQRPNVDDGLLAMALALLLISIGFMHEEVIDRMYFIVALQRKVEGVIPSPDWMQVSFQFHKWVTICLMMSWSAIMAVKFSFLFFFKRLIDRIRPWWIFDLSHKTISASIDYHTFFDPPRCAVMTFLAPRREFKTQPDTVFVSLVARYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY65</accession>
    <name>A0A2I2FY65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_439316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700872.1">
        <property type="nucleotide sequence ID" value="XM_024849810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY65"/>
    <dbReference type="GeneID" id="36557509"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439316"/>
    <dbReference type="OrthoDB" id="10280289at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB45570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="163" mass="18766" checksum="E45F9E36FCE31568" modified="2018-02-28" version="1">MTPGTSDTFRPEAFSHLCSITACHGIRYREADEPFLLIVGDYGATIGPKSTLWPRSFFNTCALPRSLLTRLVPNDEQKYLEGKYGFNWSRVSVEARLISVPTCKAHWTMTLAENRKSINISPENQELRYYDDSSYMNVHTLVILRLKNARYNTYLQMCGFRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYC0</accession>
    <name>A0A2I2FYC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Growth hormone-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_439372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700931.1">
        <property type="nucleotide sequence ID" value="XM_024849822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYC0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYC0"/>
    <dbReference type="GeneID" id="36557521"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439372"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="337" mass="37001" checksum="314D22F70A062452" modified="2018-02-28" version="1">MAFFLRRPFAVPTALRQAAPKAANNARFIHNSPFKPQSKPVGSASSSIFAKSRQSFQNAFRRTYMQPSYNAYGGGNVTQKLLYGAAIVGGTVLATNFIFNRETREDGGMPPYERSYLNDTFLHTGLGLGIIGIAARALHMNGWSYRLMAMNPWAVVGLGLVGSIGTMYGTMYTSPDNYVMKYGLWAGFNLTQAALLSPLMFMHPALLARAGLYTVGMMGSIAFVGATAKQEKYLYLGAPLLAGVTIVALSGLAPLVIPATATRTLMWSEKIWLYGGLAVFGGFTLYDVQKVLHHARMAERGLVRRDVVNESISLELDFINIFVRMVQILGMQRNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYI9</accession>
    <name>A0A2I2FYI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_478579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700928.1">
        <property type="nucleotide sequence ID" value="XM_024853572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYI9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FYI9"/>
    <dbReference type="GeneID" id="36561270"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478579"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB45626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="161" mass="17495" checksum="55D41669D67EE80D" modified="2018-02-28" version="1">MSAEMEVDQPVSQDDAPAQTGGFEPRTHAEAVAVRSIEGWIVIATNIHEEASEEDVTDLFAEYGEIKNFNLNLDRRTGYVKGYALIEYSTLPEASEAIKNLNGSKLLDQTIQVDYAFVRPPPANKGKAGGQRGGRGGGGGRGRSRSRERSRSPGADNDERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0H1</accession>
    <name>A0A2I2G0H1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_362133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701684.1">
        <property type="nucleotide sequence ID" value="XM_024844512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0H1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0H1"/>
    <dbReference type="GeneID" id="36552212"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362133"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="505" mass="55893" checksum="6D55326F67B4CCE5" modified="2018-02-28" version="1">MPLWKHDFRGRSLIIAITLASCQAFLLLGFDQGVMAGIIGAENRFGRDFNNPDADMQGNITALYDIGCVVGSIVAYFVAERLGRRTMLIAGGSIMIIGTAILASSFTVAQLIAGRIITGIGNGMNSSTAPVYQSELSPASYRGALLTLQGTVTILGVVIAYWMDYGTSYTESSLQWRFPLAFQAVFALCLVLQVIGLPETPRWLASRDRFEEAREVVAAIEDKPIHDPSVSTTILDIRTNLEEEHKGGPFRVKELFTWGENQNLRRLLIIISIELGQQFSGSNMINYYGPVMFQETMGMDRNLAMILGGCIQCTYLVGSAIPVFLMDRFGRRTLLLISTVGLCFCFVMVSILLSLGQTNAAYGATAFIFIFQIFYGSGWLCVPWYYPSEICSNRIRSRMQAIASGWNWMAVFAVVKITPIAFANIGWKTFVIFAVLNAAFFPMVYFFYPETKGLELEDLPLLFAKGGFTGGVYSSKGGRTVLPGQHAQERNVDKKVEEEQVERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G153</accession>
    <name>A0A2I2G153_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_466064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701912.1">
        <property type="nucleotide sequence ID" value="XM_024852384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G153"/>
    <dbReference type="GeneID" id="36560082"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466064"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="477" mass="55057" checksum="146EC86E53566F2F" modified="2018-02-28" version="1">MTHQTFHFFPALPPEIRRTIYILATPPRVVHIQEVSEDEKTFLAELKIAPFRRTLCPSLTHFALHWRKYIPKAIKQPTLEHFGVTGARPLNKPWTPSAATPEIPIPWLTEQPELAWEMVRNSYLYSKAPIPALLHTWSESREELIRFGYELAFRTRSNGPRTWFNFKRDVMYLTKSESRGRFSGTVSLSNNMFYEVGQFHPFDLTRVKRLALAYCGPLLFPWRAPSLWTEEIAQILPLFPGLSELLLAELEDEDVMRWSERGPHWNRNSGSSTRERWCCLAVEEIDALLSLLSDGFRTDLGSVGLVAEMFKEHQQRRESSDGYFEHRRVVTEQALADARDAMIASSHPIPMTPWSIPRIRAVHILPESMVPGMIQERRNAWNKFCELKRDWRKAIDGIPSDNFPQARAMTTKLGTMCSPLLPWLPDEDWDDVSDPVVFCIFSDEQMGGEALSRGQRRAKSWWVQKGTVKEPGLEIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1C2</accession>
    <name>A0A2I2G1C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_218651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701948.1">
        <property type="nucleotide sequence ID" value="XM_024842846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1C2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1C2"/>
    <dbReference type="GeneID" id="36550545"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_218651"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014172512" evidence="10">
        <location>
            <begin position="22"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB46646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="500" mass="56650" checksum="118AE375EF6DAE88" modified="2018-02-28" version="1">MNPITFISLAVSLLLGLQLWGWLSPRRSKLPLPPGPSFVSGPMPVNDIARTFQIWSRKFGPIVHFKLGGQNFIVLGTRRAAQDLLERRASIYSSRPPSKFLDNYLHKGLASAFMPYGPQWKLHRRLSSNLLSAKASNAYQYLQDVKSKQLLHGFLSSNDFSEAFLRYTSDVMFTLVYGKGRGSDDDDHKRLHQINEMAVFVLQKASYGMLLLDLFPYLDWLPKFLLTWRDKAHELHEKTKDVYTECSNIALQGDCWNWSHEARQRSEARELPWDVVCYSLGELYVAGIHTTKMVLEIMVMVCILQPDVMKKAQKELDSVVGADRIPSFSDIESLPYIRALVSELLRWRPISAIGVPHAVTQDDEYMGYFIPAGSTIIANQLGMNEDEAIFDNPRSFNPDRYLENPDLPVSAFGFGRRLCPGHHLARNSLHLVTARLLWAYDISPVDGKIGDPLNPASFKANFHARAPGQEKVIENESAVADRDEKAIMEKIKDKIRGVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1M6</accession>
    <name>A0A2I2G1M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_457256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702079.1">
        <property type="nucleotide sequence ID" value="XM_024851705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1M6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1M6"/>
    <dbReference type="GeneID" id="36559404"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457256"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014129630" evidence="4">
        <location>
            <begin position="23"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="375" mass="39908" checksum="5FD09AC3A0D27932" modified="2018-02-28" version="1">MAPSSCPLFFLFLFLFLHSADAFAILVAAHHPSLNLLGITTVHGNASLENTTVNATRILEAIGRPEVPVYPGHAKPFCRPAIHAPNIHGDSGIDGTELLPKPSTAPVTDKNPILAMRDALLAHPKGTPWVIATGALTNVALLFATFPEVAEHIQGLSIMGGGVGEGFTDAPMSRLKGQEARIGNVTPLAEFNVYCDPEGSQSIFSNPVLASKTTLISLDLTHQVLASPSVQSRILHGGDDASAPSTVLRQMLFELLTFFSSTYESVFGLNDGPPLHDPLAVAVILSTLNPVFAKQHPDQVLKFDDRNGERFTVSVITDGLHGTDVELVGSLGRSVVAPIAQGVAIPRGVDVDAFWNIILDCLRRADECNAARKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1P3</accession>
    <name>A0A2I2G1P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_387711</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702091.1">
        <property type="nucleotide sequence ID" value="XM_024845818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1P3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1P3"/>
    <dbReference type="GeneID" id="36553517"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_387711"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB46789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="600" mass="67725" checksum="51FA1C690D55CBA8" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2I2</accession>
    <name>A0A2I2G2I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tho complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_388258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702383.1">
        <property type="nucleotide sequence ID" value="XM_024845833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2I2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2I2"/>
    <dbReference type="GeneID" id="36553532"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_388258"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39073" checksum="1CF179EA1BFBF7C4" modified="2018-02-28" version="1">MASYGLLDQPEEDTLHKSRLLNVEEKPFKRVSKRLLHPESLVVSNATLPPTPPPEGTEEDASAATEAERQKRLGEWRHFREDVALDFAAFEGSIARIQFLLTSNEKERERYAAEKLRILGTMQSVRENTADLRVQLEEAQRLLALRKSYDELAERITSNRLLKPREDQQANLQKLQAEITDLEKESKDYATTWAERREQFGRIVDEGMQLRRLIRDEKEEVERREGMQEDEEGDDADVPSKGKSSGANTPRPDNDSVTPSQQGQDDTARSPAGLQAERYATTTGAASPLRQVTTAGDEKKQSSEKEDATMVDEGEVTADEDGDRPDELEEGEEVPDDRGADRMDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2M6</accession>
    <name>A0A2I2G2M6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_466451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702424.1">
        <property type="nucleotide sequence ID" value="XM_024852416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2M6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2M6"/>
    <dbReference type="GeneID" id="36560114"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466451"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB47122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="20316" checksum="31F4360F8F9EC5EC" modified="2018-02-28" version="1">MSTLLYNTVDRLDRPSAYYVGKKKRRYQDEMEEQEDQNAKLRGATTLYVGNLSFYTTEEQIHELFSKCGEVKRLVMGLDRFNKTPCGFCFVEYYTHQDALDCLKYIGGTKLDERIIRTDLDPGFEEGRQYGRGKSGGQVRDEYREEYDPGRGGYGRAYADDQRQREEEEYGQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3A3</accession>
    <name>A0A2I2G3A3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_478204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702654.1">
        <property type="nucleotide sequence ID" value="XM_024853536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3A3"/>
    <dbReference type="GeneID" id="36561234"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478204"/>
    <dbReference type="OrthoDB" id="2748312at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014125551" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="36385" checksum="B8E0EF25571EA52B" modified="2018-02-28" version="1">MRHPIFSLLALSSVGLAGSPRLASEELSDVKSALQAKGEFGAGRLVNASFTGFESLSGLDLFPRQSTCGTGRKRPYNRTRPQLTENADECSDGKCCKSYQNCVRGGCCDKPEIGCGADSCYNPDVETCCEARGTRCDLGYECVPSGGCCKKGRKSCGSDSCYDPEEDECCGNGKTCPLGDTCVDGGCCDGYKRKCGSYKCYDPILSVCCTDGDFSWSCPKGNSCCRSSRSCYRPSTEKCCSSGACRKGETCCEHGCCDSSERCGADGYCTVTSTSTSTTTSLSDATATITVTSGSDSDDDEETSGGGVAGADGTPGDGQGNVSGASGIRADEFLKLASMAVCASLILIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3V1</accession>
    <name>A0A2I2G3V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_385341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702858.1">
        <property type="nucleotide sequence ID" value="XM_024845723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3V1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3V1"/>
    <dbReference type="GeneID" id="36553422"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_385341"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="210" mass="24412" checksum="4CE04E48EB48834D" modified="2018-02-28" version="1">MNFELFAKTTREKQYDGLQVFLDHGWDINAESILDSKVPSALIYTFDDPDLATWFLKHGADPNKRCQLRDATPLSYAIFKAPFEIIELFFQYGGSTEHGQLLHYASMRLDANGLEIPKYLLSKSRRVMDSVNRLLDEGYLEYTMDFRFGLCTPVQYAARAGSLASVRFLVEHGADPWRLDPYKRTALSYAVRYHHEPIEYYLKDLQNQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4E5</accession>
    <name>A0A2I2G4E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G protein-coupled receptor GPR1/2/3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_361151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703046.1">
        <property type="nucleotide sequence ID" value="XM_024844454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4E5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4E5"/>
    <dbReference type="GeneID" id="36552154"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361151"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000443">
        <property type="entry name" value="Integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF41">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="7">
        <location>
            <begin position="246"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="419" mass="47657" checksum="3AF8E92A7D7092E7" modified="2018-02-28" version="1">MVGLTRILHMLSSEDARASHLVSRDPSSAHEPLSSSDRAGFISMGVIASLSFVSTFVLLCFLSYRFIFWRKYYKRPLSENQYVVLIYNLLLVDIQQATAFLICLHWVSKGAVYYPSAACVLQGWWIQVGDPGSGLFVMAIAMHTGAVVWRGRQLPYGIFVACVVGLWAFIILLGLIPVGKFTSNTFVISEAGWCWISRDHETARLWVHYLWIFLAEFGTIVLYGILFFYLQRRMRQAAMLRQNHQENLKRLNRVVIYMVIYPLVYLVLSLPLAAGRMSTARHIIQSRAYFAVAGSLMAISGLVDVLVYTLTRRHLLLETELSTSDKMYAYSNSNAYQTHITTTRDNKKFRVGSRLRRGLQSVNDTVNDDRGDSTEDIVRKGDMELVDMGQGVYQETTIEISHEPADPEEYQRESGRVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4G8</accession>
    <name>A0A2I2G4G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rxt3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703074.1">
        <property type="nucleotide sequence ID" value="XM_024849383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4G8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4G8"/>
    <dbReference type="GeneID" id="36557082"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437511"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="825" mass="89543" checksum="D193E9F53098A76E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4S7</accession>
    <name>A0A2I2G4S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_199295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703188.1">
        <property type="nucleotide sequence ID" value="XM_024842751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4S7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4S7"/>
    <dbReference type="GeneID" id="36550449"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_199295"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="304"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB47886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="438" mass="49582" checksum="D00CE2F96442D091" modified="2018-02-28" version="1">MWKPSQRLMETISHYASFPATGVSLRQMVQFGDRPSTGTLFRASQFLSEELPIRLAHRVQDLGELPDGLSEMPSIKKVQDWYAQSFEEIITLPRPTLSQEVKQRLLRPGRMNGSHSKILSEATQNPSIKEGQYRSSPTSATNGHTNGKAAAAARRYFVPSDDQGNWPPELNDYNERFAKTLQQIKRRHDSVVTTVAQGILEWKRKRQRLQIDSTVQSFLDRFYMSRIGIRMLIGQHIALTEQTHVRHPNYVGIICTKTNVREVALEAIDNARFVCEDYYGLFDAPKVQLVCKDDLNFMYVPGHLSHMLFETLKNSLRAVVETHGADKEAFPVTKVIIAEGKEDITIKVSDEGGGIPRSAIPLVWTYMYTTVEQTPNLDPDFDKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4U4</accession>
    <name>A0A2I2G4U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_199826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703202.1">
        <property type="nucleotide sequence ID" value="XM_024842755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4U4"/>
    <dbReference type="GeneID" id="36550453"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_199826"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="149" mass="17047" checksum="5CD29FE13867E5BD" modified="2018-02-28" version="1">MSMSEEIEVLKAWKYIDLATLRQGCKHVIIWYRPIFAAEESRPRLRLRLSWEQLGAGDSWEMVQIGRYTSVQFDPLSSLPVYKRRDNSGHIRDAWQVYAGTESGESLFSGLRGGKITNLHNSYPAGDPLVRELSSTSCQDRGPRKLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4V1</accession>
    <name>A0A2I2G4V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_476562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703211.1">
        <property type="nucleotide sequence ID" value="XM_024853357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4V1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4V1"/>
    <dbReference type="GeneID" id="36561055"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476562"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49725" checksum="BCBBEE89FF54C197" modified="2018-02-28" version="1">MEHSEDSLPRLRPLGPIEQYSAFRSHLGIYLNVCVTAIYQREDGRPLKPVLYRALAAMIEKHPILSAVPVDIPTKPRFARLSHIDLDQVVTSREVQGCAEDKAILEQMLQDQHNLQFLYRPGVPFWRICVLEDPSDRARFVLCFCFHHALADTKSALVFHEDLEHELSAAGEGAFTTLVAASQAPLLPNIEAIHELPISPQYLASQKVSSHPPEKWSGAPQCLPVRTRVSSMWLASATLADLKKQCRDQKTTITALMMSLIARSFFDVLPAEYTRIQGDAAMSLRSILPLPITSRSMGCYIATFDEQYARNSESVWQEARRTKETIDRAVRGQGADMPLGYLGHVPDMAQWFLDKIGKPRAAGFELSNVGFLESDRAQSGYRIQSLLFSQCAGACSPAVKVSAATGRDGRMGLAFSWQEGVVADTTVLEVMQRLERKVMNIVGRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4V4</accession>
    <name>A0A2I2G4V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_199225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703185.1">
        <property type="nucleotide sequence ID" value="XM_024842750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4V4"/>
    <dbReference type="GeneID" id="36550448"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_199225"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="95" mass="11168" checksum="58AE6928D7FBADE3" modified="2018-02-28" version="1">MTRGSPETGRGIAGERHTRITRVEGGLIDIIVCRHPAREQLSRFHTRMRDTERERRRRGRWLCAFLREILRLRLRRARTLAGSPLISHVIWRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G592</accession>
    <name>A0A2I2G592_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_447861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703349.1">
        <property type="nucleotide sequence ID" value="XM_024850923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G592"/>
    <dbReference type="STRING" id="1392250.A0A2I2G592"/>
    <dbReference type="GeneID" id="36558622"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_447861"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB48047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="435" mass="48906" checksum="2CCF7D4A964AEC09" modified="2018-02-28" version="1">MGFTKENAMIGIIGMGDMGKMYAQLLSQAGWRINACDKLDSYEDLKKEFDSRQGVTIYPNGHLVSRISDFIIYSVEAGVIDKVVAEYGPSTKVGAIVGGQTSCKAPELSAFDKHLPSDVEIVSCHSLHGPKVNPKGQPLVLIQHRASDESLRFVETVLSCFGSEYVYLTGEMHDRITADTQAVTHAAFLSMGTAWQANKQFPWEISRWVGGIENVKINITLRIYANKWHVYAGLAILNPAAKTQIRQYAESVTDLYKLMIEGRRDELKRRVREAGAAVFKADTEGQDLLLKDEVLDRFSLSKGPREETPPNNHLSLLAIVDCWSKLGIVPYDHMICSTPLFRLWLGVTEYLFRNPELLDAAIDTAIDDKTFRSDDLEFTFAARAWSDCVSFGDFESYRDRFERIQKYFAPRFPEASKLGNEMMKTILEKTSTGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5I3</accession>
    <name>A0A2I2G5I3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ketose-bisphosphate aldolase class-II family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_410797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703441.1">
        <property type="nucleotide sequence ID" value="XM_024846859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5I3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5I3"/>
    <dbReference type="GeneID" id="36554558"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410797"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="entry name" value="Four-carbon acid sugar kinase, nucleotide binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="entry name" value="Putative sugar-binding, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Four-carbon acid sugar kinase N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase nucleotide binding" evidence="8">
        <location>
            <begin position="304"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="52360" checksum="637A48AD8A133FBB" modified="2018-02-28" version="1">MASNDYPSLPRQSTLAQLPPEYPADAQDQISQTLSNSRLNRLVVLDDDPTGTQTCHDISVLTVWDIPTLTEEFRQPSAGFFILTNSRALPPAEAEVLIRTICQNVSQAAQATNQTVDIVLRGDSTLRGHFPLEADVATDVFGAADAWVLAPFFFQGGRFTINDVHYVAEGEDLVPAGKTQFAQDATFGYKSSNLKDYVLEKAPGRFSPAQLHSVTVDEIRTGGPDAVLRKLMSLPKGGVVVVNAAAESDMHVFVAGLLLAEAQGKHYLYRTGAAFVSTRLGIRSKPPISARDLSLPTPRTTGGLILAGSYVPKTTAQLKVLTDRRGPSAPSPRAENEQLAIIEISVEELIASPDSAAHVIDSVVRQTETFLSAGRDTLVMTSRKLITGGDELASLKIGSKVAEALVDVLRKVEVRPRYVIAKGGITSSDAATKGLNVKRALIVGQAAPGVPLWRCDEPTSRHRGVPFVVFPGNVGSETTLCDLVEAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6A9</accession>
    <name>A0A2I2G6A9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_448119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703718.1">
        <property type="nucleotide sequence ID" value="XM_024850945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6A9"/>
    <dbReference type="GeneID" id="36558644"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448119"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="495" mass="53303" checksum="BDB5734712C8E4A1" modified="2018-02-28" version="1">MSESATIEKSTDKISRSLTGTDKSKGTTEGLQDKQPDHEHQYPGKMKLAIILFGLNLTMFLITDQFHALGDVGWYASAYMLTVCAFQLMWGKLFTFYSIKWAYIVALFLFEVGSLICGVAPNSTSLIVGRAIAGVGSGGINAGSFLLVAYAIPPRRRPTLVGMIGAMYGFSSIAGPLMGGAFIDNPKMTWRWCFYINLPLGFVSAVIIILFLTVPGDTSSHDIPFMDQLKQMDLPGTFLVLPSANGRIIGLFAVAGVLAIAFVTIQFFSGDCATVPGRVFKKRNIWGSVVFGSCLVALCDAIPIWFQAIKGVSPVKSGIMNLPMVLSFVVFSFLGGTLTTMTGHYVQFAYLAIIFMAVGSGLLSTLKVDSGHPEWIGYQDIPIGTAILIFAENLAAAVMVSVGQNVFTNQLSKNLKTYVPSFDSGVLLDAGATQIKESVPAELYDNVLVAYNKALTQTFYVGVALCCLAVSGAAFLQWKSVKGDKKEDQTGVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6T9</accession>
    <name>A0A2I2G6T9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_509378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703893.1">
        <property type="nucleotide sequence ID" value="XM_024854668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6T9"/>
    <dbReference type="GeneID" id="36562374"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509378"/>
    <dbReference type="OrthoDB" id="3467153at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014162868" evidence="1">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="258" mass="29220" checksum="B9F53944DB1A01CC" modified="2018-02-28" version="1">MKIFASWLVWLAAVTPFARALPLQERDVNLFEERFINTLDYSLGNDSVKLIGFKTVRIPSHELNDLNDHYDSNPQEWGKLSNYFYDRASGTFRVYFPVEGALVAHDGQHHEANSLGELNLQQVNGDLAVLGRKQTDQVTGVEGNIIRDGIIFLDNAPRPLSQYGRVFVYDFGEKVILDHGHGHQKRGDKKSCMKNHGGPNCSNKFKIHSKKCKKRNDICMDYNGSFSTCKKNGPTWRNFPGSDCAKALARGHCWNEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G735</accession>
    <name>A0A2I2G735_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_382965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703983.1">
        <property type="nucleotide sequence ID" value="XM_024845624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G735"/>
    <dbReference type="STRING" id="1392250.A0A2I2G735"/>
    <dbReference type="GeneID" id="36553323"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_382965"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="243" mass="27145" checksum="7D56A8E95A9B9073" modified="2018-02-28" version="1">MTCNMSYTIQPSPSSDVRECLAVSEKSYAGFHSALYHTLPLSPESIDIMVRVREEAMDKDPQCRAYKAVDSETGAIIGVAKWSVYPEGVVIDKTVEEVVEARLTPRIPEMREDVARGLHSLMNREMRQIMAERNEGEVGNENGDGEVRKLTPHVHVDALFTHPDHQRKGIGKALLQTCLREANELGLVTFLEATEDGRPLYEKSGFKVLKECVFDAEKFGGFGGHEVTYMKKLPEKVSSNTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G759</accession>
    <name>A0A2I2G759_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_464371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704015.1">
        <property type="nucleotide sequence ID" value="XM_024852238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G759"/>
    <dbReference type="STRING" id="1392250.A0A2I2G759"/>
    <dbReference type="GeneID" id="36559936"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_464371"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="435" mass="49908" checksum="3036EEA7290F3CEC" modified="2018-02-28" version="1">MEPVDPFPRPFRMLLRPGKGSRGKNERGSEPNEKEQYSISLASDSVAPNVSNMRDEQGDNPITNQHSTRSQHANERTEHQFDSGLASFLETHEDSTQNSAGALPHDNLPSMPTTFTVPENSRHESTDRQRENDQATYIYPLINLHYSYNPEDPAMTRNESSHKQPFRPARSQRIEKQSREKARIFPCTFCYDKFKRKHDWVRHERSLHLDLETWTCAPDHDPTPEHLEEHNHNVCAGTDRTFSRKDHLMQHLRLVHHVSQVPVIENWKKNAPPFGDHGFPPSIAVQVRNAIPPYLIAQGIRTSPYLPRRNDASSEQMDLDQIGLAGPSRTSNLESTDNPQDSSQQDNLPEDIQVFSDVIALHISRFARENIQKGIFPTEEMFQKETQRLTENWKQIIADNLESVTRFQQQQAEDVQGDDVASTDPDLDTLLNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7A4</accession>
    <name>A0A2I2G7A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_407440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704054.1">
        <property type="nucleotide sequence ID" value="XM_024846682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7A4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7A4"/>
    <dbReference type="GeneID" id="36554381"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407440"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014183769" evidence="6">
        <location>
            <begin position="18"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="500" mass="54429" checksum="6E5C4FE1E1B0D2B6" modified="2018-02-28" version="1">MRLQVVTAIAAWAVTSACQSLPVTRNLWSRDADYKELSEKLSTSAKVYYPGSDEFKKASTRWSNLELPTVNIVVVPSTENDVVETVKFANKKELPFLAYNGAHGAITTLGKMTSGIEIYLDQLSGVDVAEDGKTVTIAGGTKSKLVTDTLWEAGKQTVTGTCECVSYLGPALGGGHGWLQGHHGLVADQFESMNIVLSNGTLATLDSSSELWWAVKGAGHNFGIVTSVTSKVFDIEHKDWAISTITFSGDKVEQVYEAANKYLLKNGTQPAGVINWSYWLNNPDADASNPVIIMYIIQEGVKEVDSAYTAPFEEIGPISTDPQSGTYTDLAAWTNIALDSVPCQKSGLINPRFPNYLETYNVAAQKQAYQVFADAVRGSSAFNGSIFMFEGYSMEGVKAIDAKSTAFAYRDENILSAPLITYKPDGAELDEKAAKLGNQLRQILQDASGTADVRAYVNYAYGDEGSEGWYGSESWRQSRLQSLKKKYDPSGMFSFYAPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7D4</accession>
    <name>A0A2I2G7D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_436500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704094.1">
        <property type="nucleotide sequence ID" value="XM_024849169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7D4"/>
    <dbReference type="GeneID" id="36556868"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436500"/>
    <dbReference type="OrthoDB" id="4267316at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="317" mass="36122" checksum="6E5DD0FCFC908D94" modified="2018-02-28" version="1">MDSPNTFPYTKGHRLRISSHVAPAPTPVTIDCCRDGQAGREERARLTPLQRCIEHPPLPGNSGSESADLEILDPLKVGEAHNAQVFIAEMHETGTTDHAKNKVVAKVYDPLYFDDQDGYLNPFRCVDKHYTHEVHTYTLLAHLQGSLIPKFYGSFSLEIPGPGSTFRGVRLIVIEYIPGLSMLQAHPENYPSPCRQQIVKSVIDFESRAYERDIVLTDLCPRNVMLLDPNDYPQRTIVFLDFGGAIFGRRLDGPRTIRSNLFLGQYISPLVRWSSSMSFLFSDWIDWEMRPWIEAEYSHEVASVTEEMRKKFSYNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7F1</accession>
    <name>A0A2I2G7F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_383111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704107.1">
        <property type="nucleotide sequence ID" value="XM_024845632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7F1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7F1"/>
    <dbReference type="GeneID" id="36553331"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_383111"/>
    <dbReference type="OrthoDB" id="5054768at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="31137" checksum="86E8695850182D92" modified="2018-02-28" version="1">MSSTIGYYNGTAEFKLTPLTDRDYDEPPCEPLRNISVTSSWNSILSIIEPGSKNIGSNPVNLVLNSFLPNYDWSKSPRLGLLWGNEGLLWPLLSAIPTWSNESTTDNFNLTSSKASSAFHLSGMVNKGASSSSFPMSNFSFPACNSSMETGNWTVELQVGKWPLTKGWSGFRLPTTNTSFNDRTANVSISGIFRATAWLHTNASRTLAVGSSILGSLELEFRGILDPYHSDVLDMDSPTPKWLRTVGFGNNSLNIDNDATSAAATSWALRGGSIIVLPVLSLILNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7P8</accession>
    <name>A0A2I2G7P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP-binding protein Obg/CgtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_455718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704206.1">
        <property type="nucleotide sequence ID" value="XM_024851562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7P8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7P8"/>
    <dbReference type="GeneID" id="36559261"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455718"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="7">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="256"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="869"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="836"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="937"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="874"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1054" mass="116491" checksum="CBF30108781F664C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8G1</accession>
    <name>A0A2I2G8G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_436785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704460.1">
        <property type="nucleotide sequence ID" value="XM_024849221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8G1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8G1"/>
    <dbReference type="GeneID" id="36556920"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436785"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="19040" checksum="6086770C87EAF93A" modified="2018-02-28" version="1">MPDFFEGQPADISWFPPQTDDHKAKLGNFFQTKAAPPATLSRIPDVVKEANQLAPAGSFDWSILGYCWGGKITALATGQENTTFKAAVQCHPAMLAPDDAKSVNVPMAVLASKDENAADVTAFGDNLAKPHYVETFGTQIHGWMAARSDLENEEVSKEYERGYRTALDFLHKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Q1</accession>
    <name>A0A2I2G9Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein MMF1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_437150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704875.1">
        <property type="nucleotide sequence ID" value="XM_024849297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Q1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9Q1"/>
    <dbReference type="GeneID" id="36556996"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437150"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="125" mass="12901" checksum="D558CFC101A8AA0E" modified="2018-02-28" version="1">MSAITNVTAAGACPPAGPYSQAVRANGQVFVSGQIPADASGNLVSGNIGDLTQACCNNIKAIVEAAASSVNKIVKVNVFLTDMANFAEMNATYEKFFTHKPARSCVAVAQLPKGVPVEIECIALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9Q8</accession>
    <name>A0A2I2G9Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_356616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704919.1">
        <property type="nucleotide sequence ID" value="XM_024844164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9Q8"/>
    <dbReference type="GeneID" id="36551864"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356616"/>
    <dbReference type="OrthoDB" id="5355526at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="73" mass="8195" checksum="FF001E6433679851" modified="2018-02-28" version="1">MCYKLVERFSVCGCLYFQHAVDPCEAYGQRGHTVQEKTVLVGYTCDKHTVRRGEPTPKGTTWPDSGYSSAKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAK4</accession>
    <name>A0A2I2GAK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_133624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705213.1">
        <property type="nucleotide sequence ID" value="XM_024842429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAK4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAK4"/>
    <dbReference type="GeneID" id="36550125"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_133624"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF42">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="155" mass="17730" checksum="FAC31A29E02A24CC" modified="2018-02-28" version="1">MSITLTTLKPENYASWASLWKQFITHCEAELPQSQYEDTFKRIVEPDGNLQAHVLVNDTGAVVGLAHYFFHQSVWNPHHVCYLSDLFVDSSLRGKGCGRTLIEATAKSAEEKGCRRLYWAAYHTNTPARRMYDTVADAKCEFVEYRMPLNTEKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBR8</accession>
    <name>A0A2I2GBR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_508506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705607.1">
        <property type="nucleotide sequence ID" value="XM_024854583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBR8"/>
    <dbReference type="GeneID" id="36562289"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508506"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="452" mass="49384" checksum="69C9800CAF2A2A24" modified="2018-02-28" version="1">MDDKKVVLESASSEELEQGAVVQSAGYDQKATKQLIRKIDWVLIPWLAFLYLLSFLDRTNIGNARLAGLEEDLGMSGLDYNVALAIFFPFYVAAEIPSNLMMKKSRPAIWIPIIMLAWGVVCSLMGLVNNYGGLLAARAALGIAEGGLFPGVTFYITMWYKRHECGLRMAIFFSAATAAGAFGGLLARGIVEMDGLGGKAGWAWIFIIEGLVTFAVAIAAFFIMNDYPDTAKFLTQEERTEVQRRLTEDTSSLATEFSMKYFWDAVKDWKIWVHMFITIGIYTPLYSFSLFLPTIVKTLGYSNTTAQLMTVPPYVVACVFCIGGGFMADRQGQRGIYMIFFNVVAIIGFVMLLASDNNAVKYAGTFFAATGIYPNVPQGVAWNGNNIGGSVKRGVGIAMHVGFGNLGGVVSSFIYQSKDSPHFYPGHGTLIGTLSMSTVLCIFMTSAVCNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC93</accession>
    <name>A0A2I2GC93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_445772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705777.1">
        <property type="nucleotide sequence ID" value="XM_024850735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC93"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC93"/>
    <dbReference type="GeneID" id="36558434"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_445772"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB50475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="296" mass="32656" checksum="80629BBD2BF943BA" modified="2018-02-28" version="1">MHPVDPVLVLDPAILPDPAAAAEDDSDYEYEYHDHATETFYLTLDLASNQNLGRPSKRRQDSQSVTTPRSLPTESSHRDGNEPALASTEVDSTPEERVQILGLHTPNPIVSYRNQIFNCSWADQIGTELLFAQPEVESDPDSAAPTKPLRRGKDFDLIAANSVKIFGRKANLISSAGPAPPMEPLEADVAQDTDPATTRRTGPMSNQARFLERLKSIKQAKGETDTIRSSFSLRRAQNLEERLRGWAQTGEQLTEIQRLNDAAVQGNTTAMADLENLYIQLGSQDHGLPAEAFQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCR5</accession>
    <name>A0A2I2GCR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_508825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705981.1">
        <property type="nucleotide sequence ID" value="XM_024854607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCR5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCR5"/>
    <dbReference type="GeneID" id="36562313"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508825"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="574"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="757"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1169"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1170"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1259"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB50679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1268" mass="143167" checksum="B46BB52F62606601" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDD4</accession>
    <name>A0A2I2GDD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_446088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706185.1">
        <property type="nucleotide sequence ID" value="XM_024850765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDD4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDD4"/>
    <dbReference type="GeneID" id="36558464"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446088"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="52"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="401" mass="43800" checksum="E03A3136B6457A08" modified="2018-02-28" version="1">MVPIPTFEVERWMDEYEMTPGVLNTAETCAASVSLDELAALAGNKSNSNPVDTSMSLVYGAIRGTADLRAKVASLLGQSSLGNNNLLGADDVLITQGAIAANFQVLFTLLRPGDHVISVYPTYQQLYCVPESIGAEVSLWKLQEHNGFVPDISELEGLIKPNTKMIIINNPNNPTGVTIPGKVLKKIASISRARNLVLFADEVYRPLYHDLFQEDADLPPSAVALDYDNVVVTGSMSKAYAMAGIRIGWVASKNKEIIGALASSRDYTTISVSRIDDQIANYALSDAIRLPLLKRNVELARKNLDLLGDFVDRYGHILSWVKPNAGTTAFIKIAHNGVPVDEETFCKDLISKTKVFFVPGRRCFGDGQDFAGFIRVGYVCHTEVLEEALALLGPYLEKTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDF3</accession>
    <name>A0A2I2GDF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_155329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706173.1">
        <property type="nucleotide sequence ID" value="XM_024842542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDF3"/>
    <dbReference type="GeneID" id="36550239"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_155329"/>
    <dbReference type="OrthoDB" id="10494519at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="124" mass="13883" checksum="ABDDD3B3AD66FB91" modified="2018-02-28" version="1">MTPKGEGRHSCIYICIYLQAVERSTRDLREHILLLPLCLSAPHTIMAVESKHAAKLIVSVMVLWAISATSFILRAVSIQMRKRSWKSHDYLTALALLCFTGYAADVTVGKCVLFTRMPLDDEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEU4</accession>
    <name>A0A2I2GEU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_78828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706702.1">
        <property type="nucleotide sequence ID" value="XM_024855387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEU4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GEU4"/>
    <dbReference type="GeneID" id="36563094"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_78828"/>
    <dbReference type="OrthoDB" id="4507372at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014111482" description="Extracellular proline-rich protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB51400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="28911" checksum="BC9D9DF86C1D0E57" modified="2018-02-28" version="1">MYFSVTLLASLAGSALALPGRHTPIANGTVTPSSSFSTLVPTPSKNGTVTTHYPPTTGNPQSTGATVTETGSVSTITSTITRTTFEPCSTAVSTRDGTTYYSTWLSTSLYETTTCFTTTVGSTPQTTVTNLPGTAETTVPTAHPGGPGASNCPAPVTVTVTETVKEGSGSVPTLHPGKPCARCETVTYTNTEGHTKTIVIPPSGEPTAEPTGEKPGHSTATTTVLSGTESATTTAKPTFTHTRPIGNGTYPSHTSPVSSSVGSGSAQPSITPSLRRVAWKPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GEV2</accession>
    <name>A0A2I2GEV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_164937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706683.1">
        <property type="nucleotide sequence ID" value="XM_024842589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GEV2"/>
    <dbReference type="GeneID" id="36550286"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_164937"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB51381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="51" mass="5564" checksum="88092CE24CDA0A62" modified="2018-02-28" version="1">MVVVNPGFHFPFILLFLVISSPVVVSLSPCFVAVLGCHRELSQPNFSFAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFM4</accession>
    <name>A0A2I2GFM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="18">1.3.8.6</ecNumber>
            <ecNumber evidence="4">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">P170DRAFT_453310</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 23">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="16">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="18"/>
    <dbReference type="EC" id="2.3.2.23" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706992.1">
        <property type="nucleotide sequence ID" value="XM_024851356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFM4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFM4"/>
    <dbReference type="GeneID" id="36559055"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_453310"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 23" id="KW-0274">FAD</keyword>
    <keyword evidence="5 23" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="24">
        <location>
            <begin position="399"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="22">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PLB51690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="554" mass="60591" checksum="7A42412D7D3ED6C6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG19</accession>
    <name>A0A2I2GG19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall assembly and cell proliferation coordinating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_506729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707102.1">
        <property type="nucleotide sequence ID" value="XM_024854411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG19"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG19"/>
    <dbReference type="GeneID" id="36562117"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506729"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="158"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB51800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="535" mass="58507" checksum="8E8B0A6D9D1EA8D0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGX2</accession>
    <name>A0A2I2GGX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707433.1">
        <property type="nucleotide sequence ID" value="XM_024852902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGX2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGX2"/>
    <dbReference type="GeneID" id="36560600"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472040"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="205" mass="22283" checksum="E6B87059AAEAE97C" modified="2018-02-28" version="1">MAGFPSSGSKPEKSMSSRLLTMKFMQRAAASAAVNESQSPADTPSPKRHRAEQEAASPATQSDLEAISAALAEEERQRKEAVSRKAAEAGESEWVLDFDTPQYAPQPRVVTADSLDADDRNMVSGGRQKFGNFKRMKTITTADGETMTLGEDEADDVLKQEKEEAQKNRKPVRIDKITSISGAGGVVKDRSTGSPSQSKKKRKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHE6</accession>
    <name>A0A2I2GHE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Developmental regulator FlbE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_507123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707596.1">
        <property type="nucleotide sequence ID" value="XM_024854450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHE6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHE6"/>
    <dbReference type="GeneID" id="36562156"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507123"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22834" checksum="43159094C6B731E2" modified="2018-02-28" version="1">MPVYLLYGFRWPRAGFTGIRVYIVLHNLEDATAEYLQQPLTTELLLNSFKKTEPGIVSRLPDMRFIEQYDPEDTSEEAVSKTHAYVAGKVITMPEVGSPGACLSFDAEELVKSSGLDQDGMEALTEMRDKYAAGEKIGWYIVYNGDPDRYFPPDEEDEDDYSLEEEDEEDEQVNGSEYGNGTASRPPSTPTSLLTRFFTKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHG1</accession>
    <name>A0A2I2GHG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_488913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707625.1">
        <property type="nucleotide sequence ID" value="XM_024853978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHG1"/>
    <dbReference type="GeneID" id="36561679"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_488913"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49937" checksum="406A7E0856C58F64" modified="2018-02-28" version="1">MGPRFFWCYYHVRATKTFLTVLLIWISIFVYCRFHLWRDPHSAFFNDRHVYNLDYSLYREREARHLISRYNSPSDPPQPIRGGPEPLICVSFVTVRRKLDDYFDPSVGSLLEGLYEEERQALHIEILFADTDPTRHPSWGQKWVDRLVDSAGSYNVSEVELDHLRELEKQRNFYEKGVYDYVYALKSCQATKAPYTIIFEDDIILATGWLTKTLKALSDITKPTQNKQKPWIYLRLFYTETALGWSTSDFAYRNMFFIFGLLMLSSCLCLLLLRRFRICRSYLDYTNMAVICLVCVPAFIALVYMMGKYTLMPLQGVVEMNKYGCCTQGMLFPEDQIDGLIGFLGEKGHGQTDSLIEEYADQTGLTRYALAPPQLQHVGLKSSRDNLDINTQSTWAFWFEENDPEALRKEDERLFGDRDVQMTLNGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHW6</accession>
    <name>A0A2I2GHW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_423347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707777.1">
        <property type="nucleotide sequence ID" value="XM_024847502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHW6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHW6"/>
    <dbReference type="GeneID" id="36555201"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423347"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="3">
        <location>
            <begin position="15"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="282" mass="31052" checksum="F72EDE2B56E08F6C" modified="2018-02-28" version="1">MVTRIGAFVGPQTQLGESPLYREFDNTLHYVDVIGKTINVLQLDDNLKRRTINCPEHITFLAFHKDGGYLICSFSSIVHVLNDGTWSVLKQVIPDTTKERLNDAGIDTHGRLWVGSIDRVTEAIPKLSGGAKVYEAKGSIYRYDPDGNLVVAQKGGVMAGNGLCWSPDNKTMYHVDSYINVSLLDIHFAYHQADSAQSIHAYDFDTIAGTISNRRLVQWDLNACRVTHGAWVGPDNRDLVVTTAQRDESSPAWEGEEGGALFYIRGCDSAGLPKYGFGVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIC3</accession>
    <name>A0A2I2GIC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_507386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707933.1">
        <property type="nucleotide sequence ID" value="XM_024854481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIC3"/>
    <dbReference type="GeneID" id="36562187"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507386"/>
    <dbReference type="OrthoDB" id="4483326at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="116" mass="13708" checksum="71FD2020B54D9AD3" modified="2018-02-28" version="1">MCYKTNYEPYTSQSQSFDMTRERSSEEILYPLGTLYPHVVALQLQADENPWTQANSFSGYHDISYWAEISSHGPTEDYSRPRPSTARRYSDSTALKFVSRIRRFLSRDEIRRRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GID2</accession>
    <name>A0A2I2GID2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_351385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707943.1">
        <property type="nucleotide sequence ID" value="XM_024843863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GID2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GID2"/>
    <dbReference type="GeneID" id="36551563"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_351385"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000220">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000044">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056584">
        <property type="entry name" value="EF-hand_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23617">
        <property type="entry name" value="EF-hand_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="3">
        <location>
            <begin position="385"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB52641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="660" mass="72222" checksum="1722CD66E9E032F7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIQ6</accession>
    <name>A0A2I2GIQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_507506</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708065.1">
        <property type="nucleotide sequence ID" value="XM_024854494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIQ6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIQ6"/>
    <dbReference type="GeneID" id="36562200"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507506"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="353"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="457"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="519"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="612"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="676"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB52763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="751" mass="82729" checksum="29731D3CD592EE70" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIV5</accession>
    <name>A0A2I2GIV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrodipicolinate synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_403358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708114.1">
        <property type="nucleotide sequence ID" value="XM_024846471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIV5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GIV5"/>
    <dbReference type="GeneID" id="36554170"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_403358"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="335" mass="35888" checksum="637854B2CAF963EF" modified="2018-02-28" version="1">MSSRTPLRTGVYAPTMTFFNPDTEELDVPTIRKHAVRLAKAGLVGLVTMGSNGEAVHLTREERKTVIRETRSALVEAGFQNVPVITGASEQSIRGTIELTKESAEAGAEYALIVPPSYYRYAVGNDQTLYDYFTAVADASPIPIILYNYPGAVSGIDMDSDLIIRISQHPNIVGTKFTCANTGKLTRVARALNAITPESPLVTPRKNTSTKKAENHPYVAFGGIADFSLQTLASGGSAILAGGANVIPKLCVHIFNLWSAGRFAEAVEAQQLLSAADWVLTKTAIPGTKGAIQSYYGYGGYPRRPLGRLSAEQTQAVADGIKEAIELEKTLPDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJK5</accession>
    <name>A0A2I2GJK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_472940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708364.1">
        <property type="nucleotide sequence ID" value="XM_024852996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJK5"/>
    <dbReference type="GeneID" id="36560694"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_472940"/>
    <dbReference type="OrthoDB" id="4506111at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="305" mass="33655" checksum="EC65116A27F32EF6" modified="2018-02-28" version="1">MTGTPTSRQNSVPPRPDRESFDSDSPHAEHVEVSHAPETRTDIGLNDLGTFSSRAAGPSSITRRTNILADPRAALPGFTWSFGQSDSQQSHEVPNTSSDAKATADPSHGIPFDPKYMTINISFGHTMPAPRWVLEPRATPRRLSIPQASAVAELEWVFDVGPYTHLTALKDTWLSEYAYRTLESALDDPIQRQHIRNNIWARDDDEYWTIEDPIPPLPSVPNTLDVTQQREGLTPGSVNERLLHYPNYERPSLAKRCLVEPPDPENQESGGGTDEEGAPRTPSVSSGTDDSSPDGKKLPIFNTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJR6</accession>
    <name>A0A2I2GJR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_423898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708423.1">
        <property type="nucleotide sequence ID" value="XM_024847534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJR6"/>
    <dbReference type="GeneID" id="36555233"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_423898"/>
    <dbReference type="OrthoDB" id="4522394at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="104" mass="12074" checksum="288FB5B678025935" modified="2018-02-28" version="1">MAPKTIQHISLPEARGLKYDESDMALFHAKLSYHSTIEARKASADNNLRSISDHQARIIKRWEMLKQVEKEMTEKGKSLSPAERSQLAQYEWRFKTLEELAKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK40</accession>
    <name>A0A2I2GK40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose-phosphate pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_473113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708543.1">
        <property type="nucleotide sequence ID" value="XM_024853012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK40"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK40"/>
    <dbReference type="GeneID" id="36560710"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473113"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000047">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="432" mass="46660" checksum="89AB756019A7490E" modified="2018-02-28" version="1">MVRNIVVIGGTSHPQLTQNICGVLGIPPADVLLSKFSVGETRVEIKESVREKDVYIIQSGGGKVNDHLLELLITVSACKTASARRVTAVLPLFPYSRQSDIPYNKSGAPLVKSHVTGKPGGPGYTFESTPSTPHPGNPESGSMLNGVDNLQKGLAKAQLDDFNNGSPVKRRPANGLPRSDTIDSLKSEATTNGANVTDDSAEKISNFQPRPGYKQWVAQAGTLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGRPLLKSYIQRNIPSYKHAVVVSPDAGGAKRATAIADSMGMEFALIHKERRPTRITERQNATMMLVGDVKDRTAILIDDLADTSNTITRAAKLLKKEGAAKVYALVTHGILSGDAIDRINASALDKVVVTNSVDQADHLRRCPKLEVLEVGNVFAEAIRRVHHGESISVLFQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK51</accession>
    <name>A0A2I2GK51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_463021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708568.1">
        <property type="nucleotide sequence ID" value="XM_024852129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK51"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK51"/>
    <dbReference type="GeneID" id="36559827"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463021"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="214"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="727" mass="82370" checksum="D561B1AA53B7F78D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKF3</accession>
    <name>A0A2I2GKF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_325644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708639.1">
        <property type="nucleotide sequence ID" value="XM_024843342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKF3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKF3"/>
    <dbReference type="GeneID" id="36551042"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_325644"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014114226" evidence="1">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="195" mass="21762" checksum="A8D4C44158B6D150" modified="2018-02-28" version="1" fragment="single">TIISSFAVILSLIAATLAISKHIPHKDSQTFHFECGETPSDAARLGCKFDLSAFAWVPPACFDGEMMEDFLNSSDWKWSLDREGQQMVSEEYARTGDFEYLYTTATYHATHCKYAYKRLTRAMLLRDQSGIDGYIGGIGHVDHCMHMIEMAAAGNTDIWGTGKAYTKMASCGQGVFESGNGWFGWDNGQKIWELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKT5</accession>
    <name>A0A2I2GKT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_473353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708794.1">
        <property type="nucleotide sequence ID" value="XM_024853030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKT5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKT5"/>
    <dbReference type="GeneID" id="36560728"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_473353"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB53492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="746" mass="83533" checksum="AB1DE1F0EE35F4AA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKV1</accession>
    <name>A0A2I2GKV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_454522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708789.1">
        <property type="nucleotide sequence ID" value="XM_024851442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKV1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKV1"/>
    <dbReference type="GeneID" id="36559141"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_454522"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="33"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB53487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="19372" checksum="B9ED466973428014" modified="2018-02-28" version="1">MSLFRTIPSGNDFGALFRLLDDYDVHRSSRSQTSVRSFAPRFDIRESSDAYHLDGELPGIAQKDVDIEFSDPQTLVIKGRSEREYHTPEAGEGTNESAQGERSEVAQTGEKQVTKSEGKPRFWVSERSVGEFHRTFSFPSHVDQEKVKASLKNGILSVVVPKASAPSSKKIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMH5</accession>
    <name>A0A2I2GMH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_442215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709351.1">
        <property type="nucleotide sequence ID" value="XM_024850449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMH5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMH5"/>
    <dbReference type="GeneID" id="36558148"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442215"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="95"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="348" mass="39662" checksum="97C0532EE99566C2" modified="2018-02-28" version="1">MSPSRNHHGWSYQQVAAASFLKAFLRTFTTLRIKWPLSLKPHHESTRFVVIDPATPDLYSGVATDKHIKPDRIGGTWYPEPYTPQTSLRENQHVVLHFHGGSYILGDGRTSSCGFLAKSFLEYTPTRFILCPQYRLATHHHSRFPAQLQDAITSYFYLLHTLRIPASQIILSGDSSGAHLALALLRYINEFNNTDFLPVPKCAWLWSPWCDVPAAVNASAWTRSENYKTEYIPGSFPAWGARSFLGDLEITEPVERYLAPLWHPFRVPCPVLVGTGNREVLFHEHERLVEVLGEYVDREFEPGVELVVADKVPHDVFMIGWIMDFKEEARDCAVRAGKFVDRIECSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMM8</accession>
    <name>A0A2I2GMM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_347225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709453.1">
        <property type="nucleotide sequence ID" value="XM_024843617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMM8"/>
    <dbReference type="GeneID" id="36551317"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347225"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="552" mass="58932" checksum="6AA9FB1774764926" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNV9</accession>
    <name>A0A2I2GNV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_442649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709864.1">
        <property type="nucleotide sequence ID" value="XM_024850474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNV9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNV9"/>
    <dbReference type="GeneID" id="36558173"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_442649"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB54562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="348" mass="37055" checksum="9853FA8B0A9EBFE4" modified="2018-02-28" version="1">MAPTGTMKQWSVASKDKDFDGLSYGDAPVPNVGENEVLVKFHGASLNYRDLIIPKGLYPFGVNFPTIPGSDGAGEVIGVGSKVTQFRKGDNVVTLFNQGHQYGPIDLAAAQSGLGGAVDGVLRQYGVFNENGVVKSPKNLNHLEASTLTCAGLTSWNALYGLKPLQPGQTVLVQGTGGVSIFALQFAKAAGASVIATTSSEEKGKKLKELGADHVINYKTNPNWGEIARTLTPDNVGVDHIIEVGGSGTLTQSFKCIKFEGVITIIGFVGGTDPESQPPVLSTLNNICTVRGIYVGSKALMNDMVKAIEVNDIHPVLDAKVFSLEQTREAYEYMWAQKHFGKVAIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GP20</accession>
    <name>A0A2I2GP20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_373922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709922.1">
        <property type="nucleotide sequence ID" value="XM_024845264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GP20"/>
    <dbReference type="STRING" id="1392250.A0A2I2GP20"/>
    <dbReference type="GeneID" id="36552964"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_373922"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EVE" evidence="8">
        <location>
            <begin position="126"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB54620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="310" mass="34612" checksum="F69CC2F4288723CA" modified="2018-02-28" version="1">MPPNNTKKRKSDGASLADEASSPKRAAVPSTGEKRKRGRPRKYPEGTIPKPSSGRGRGRPRKDPNATDTPSKPKTPQEGKRPVGRPRKSLGDTPLNGTPSRSEQRKSASADAKAAEDETDSSGRSYWLMKAEPESRIEKGADVKFSIDDLRERSKPEPWDGVRNPAARNHIRQMKKGDLAFFYHSNCRVPGVAGIMEIVQEHSPDESALDPQHPYYDEKSTREDPKWDVVHVEFRRKFKNFVPLTDLKSHANSGGQLANLQMLKQPRLSVSRVDKKEWDFVMGLAKEEPESEQSAESSKEDASAEDESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPD1</accession>
    <name>A0A2I2GPD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-xylanase</fullName>
            <ecNumber evidence="13">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_470176</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="13"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710033.1">
        <property type="nucleotide sequence ID" value="XM_024852720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPD1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPD1"/>
    <dbReference type="GeneID" id="36560418"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_470176"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000094">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="14">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB54731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="324" mass="35031" checksum="AB9ABBEFE5B3B113" modified="2018-02-28" version="1">MVYIKNLAGTITLLASIASARVITRQASASIHEAFTSHGKKYFGTASDQGLLQNSQNEAIIAANFGQLTPENSMKWESTEPTQGSFTLDGADALVDYAQSNEKLVRGHTLVWHSQLPSWVSSISDKDTLTDVIKEHINTVMGQYKGKVYAWDVVNEILDEDGTLRDSVFSNVLGEDFVRIAFETAREADPDAKLYINDYNLDSADYAKTKGMVSYVKKWLDAGVPIDGIGSQTHISEGGFPSSALDALASTGVSEVAVTELDIAGASSEDYLNVVNACLDQEACVGITVWGVSDKDSWRSDSTPLLFDSNYGAKDAYNAIVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPS2</accession>
    <name>A0A2I2GPS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_421507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710171.1">
        <property type="nucleotide sequence ID" value="XM_024847366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPS2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPS2"/>
    <dbReference type="GeneID" id="36555065"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_421507"/>
    <dbReference type="OrthoDB" id="4179617at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB54869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="233" mass="26934" checksum="C745DEB27C7ACC75" modified="2018-02-28" version="1">MAKIAPADWPDRLQKKIDAIVQDFREKREIRQAFREARQERRREEELPKFLSSTSLSPQETLDSVSIRPVWREGLRFWDFTSQDLPAVPLSLVESLEELGEMVQNSPVNEAIIRMKVNIFIRSALRQAGYKRAHLQTERRLQINRYINTKMHTITGFADYAVWYGDDPADESTSIMIIETKQSKENGLYQGLSNVAMVHYLRIKAGRSNRTVYGVSADAIEWQFVSLAADRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GPS8</accession>
    <name>A0A2I2GPS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_460881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710178.1">
        <property type="nucleotide sequence ID" value="XM_024851980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GPS8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GPS8"/>
    <dbReference type="GeneID" id="36559678"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_460881"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF68">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014172527" evidence="3">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="33"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB54876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="383" mass="41446" checksum="4902E1CDC1B5B8D7" modified="2018-02-28" version="1">MPHLLSMAAAAAALPSALAATLDMPVHFFNSYANVEVEIGTPAQSYMLHFDTGSSTAWVNDKSCGDACLNTSGFDRTYYDVTASSTGVSRGARASMDYFGGVTGGPTFEDKFSVPVGDKAFTWRQSFLSADQSSWNNLGADGFMGLAFNSISDGNTTTVVETLMQQGQLDEPRFGIYYGTEFNQTGSNPDGVLTIGGSREDKYVDGEITYVPLRFETHEVWRTVLSSITGTTENGGKKKSASNSLGFLGNAVFDTGAGSISVPNSIVDEIYESFGWDYEAILHGKHIPLCSEFNSTWSVTFNFGDGNLDPNLTMTGDQFARPGFAYRDDACYPPFEGSDNEGMALIGTPLMQQFYTIFDFGGKTADDFHPRIGFGQLKKEVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR69</accession>
    <name>A0A2I2GR69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_399455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710665.1">
        <property type="nucleotide sequence ID" value="XM_024846282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR69"/>
    <dbReference type="STRING" id="1392250.A0A2I2GR69"/>
    <dbReference type="GeneID" id="36553981"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_399455"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="360"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB55363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="476" mass="51251" checksum="9E8E84CF89AA90D1" modified="2018-02-28" version="1">MAAEGFPVRVLPAIDPAHHSFIEPGKKIHEGGDVSDFLCSKGYVDIMTLLLQLNRSMFPEKLSDGSVQTWPLNSDAVEYSAPVRQLQQLLSKLEGIIAEAPPDTGPRRFGNVSFRKWYQIVESRVSTLLEECLSSEILQKPSSDPNGPTAEVELKAYFLGSWGSSQRLDYGTGHELSFLAFLAGIWKLGGFPKNAAGVEERALVLGVIQPYLELVRTIIKTYTLEPAGSHGVWGLDDHSFIPYIFGSAQFAPALGESDKVPDEGSLPNAPDPTGVSKANIVERERRDNLYFSAVGFIYDVKKGPFWEHSPMLYDISGIRTGWAKINKGMIKMYNAEVLSKFPVVQHFPFGSLFSWERDPNALPPPSTAHSSSGPQARPQGSAAPAPTTQPSGAGTKAPWVSASQSVPQSGTAAPWAVSRGPGVPSASRNPPTLPNTSNLPPGPMTPTRAPWASSQPPTAPSGTAQGDVVTKAPWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRJ6</accession>
    <name>A0A2I2GRJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710807.1">
        <property type="nucleotide sequence ID" value="XM_024848392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRJ6"/>
    <dbReference type="GeneID" id="36556091"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433031"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="68" mass="7888" checksum="79C6730C43BB9C00" modified="2018-02-28" version="1">MRHIQVHTSAQQKPINAKIKHSPETRLNLYPLYGLRVAIPCLGPSFVLFSLRRDYPLRTITPSNYIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRV2</accession>
    <name>A0A2I2GRV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_422134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710902.1">
        <property type="nucleotide sequence ID" value="XM_024847418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRV2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRV2"/>
    <dbReference type="GeneID" id="36555117"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_422134"/>
    <dbReference type="OrthoDB" id="3940621at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB55600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="337" mass="40061" checksum="7E13FB62E89247AA" modified="2018-02-28" version="1">MAQPGLEFAPESDWATIFYQRHGKHWQEKRGHEKYATWIVRDQLPSLQRFSRFPFQRLRTLQVLIRAPDPNDPGRMFWLWHKAASLSQMLNQARQVERIHIRHHAYDDSTHWDRFSSAFRETSVSQMDLDMVLPGFLALQNVGSLYTSLYQVHPQQKAMTATIWRDPLTLTAIGKILIWLQIHQIFWSRSADQDPWGISAEWVKSALTQDPSPFIEFQKRYWQTLKRFPVLIMDHDRLFLMVKDMHLAIVALYHYATEKYHDPQGPASQRPMHVVFQNWQCVDVEYDMALEGRYREYMRLYGYYHEPEVSDMVKARICAQTPYPSLDRRSFWSVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRW4</accession>
    <name>A0A2I2GRW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BNR/Asp-box repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_45296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710905.1">
        <property type="nucleotide sequence ID" value="XM_024851320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRW4"/>
    <dbReference type="STRING" id="1392250.A0A2I2GRW4"/>
    <dbReference type="GeneID" id="36559019"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_45296"/>
    <dbReference type="OrthoDB" id="2130735at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014122725" evidence="1">
        <location>
            <begin position="16"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="374" mass="41527" checksum="F0FE2789834FE793" modified="2018-02-28" version="1">MHFLHLLTLAPLALAASISKARIPTYSQNVIFSPPSDYTIPRTLYARNEQLPNGDLLATWENYSPEPPAVYFPIYRSKDHGQTWKEISRVHDTANGLGLRYQPFLYYLPERVGSFKKGTLLLAGSSIPTDLSSTQIDLYASRNSGKTWEFVSHIAAGGEAVPNNGLTPVWEPFLLAHKGKLIAYYADQRKNETHGQHLSHQVTTDLKNWSPATDDTAYPTYTDRPGMPVVAKLPNGKYIYVYEYGSFFNTSSYSFPIYYRISADPENFNAAPHQRLVVSSGTVPTSSPYVVWTPYGGKNGTIIVSAGTQDSIFINQALGEGEWTEIATPEGHSYTRSLRVLREDPSKLLLHGAGVLLGKTNKVTVSVMDLKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRZ2</accession>
    <name>A0A2I2GRZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_433160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710953.1">
        <property type="nucleotide sequence ID" value="XM_024848416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRZ2"/>
    <dbReference type="GeneID" id="36556115"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433160"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="113" mass="12113" checksum="77D1949A2A572A19" modified="2018-02-28" version="1">MFALKTALPSMRSVATTRGLVSARSLSSSASMRNAATSSLPAKKPVGAFRGGLFGFLAGSLTAGASVYYYILGEYRTSNEMLTEDISALQSATHRLQKYIGELESKVDQLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS57</accession>
    <name>A0A2I2GS57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_433220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711013.1">
        <property type="nucleotide sequence ID" value="XM_024848428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GS57"/>
    <dbReference type="STRING" id="1392250.A0A2I2GS57"/>
    <dbReference type="GeneID" id="36556127"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433220"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="108"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="410"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB55711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="512" mass="57959" checksum="CE3C27E61681F76C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GS74</accession>
    <name>A0A2I2GS74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mus7/MMS22 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_443444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711022.1">
        <property type="nucleotide sequence ID" value="XM_024850545.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GS74"/>
    <dbReference type="GeneID" id="36558244"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_443444"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2250" mass="251995" checksum="04F664EA1163439A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GSD8</accession>
    <name>A0A2I2GSD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbohydrate-binding module family 18 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_347218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024711091.1">
        <property type="nucleotide sequence ID" value="XM_024843616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GSD8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GSD8"/>
    <dbReference type="GeneID" id="36551316"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_347218"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="371"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="425"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="479"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB55789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="54559" checksum="E8777FBFF9A31E7F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQ97</accession>
    <name>A0A2I2FQ97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_469070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000027">
        <property type="protein sequence ID" value="PLB42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQ97"/>
    <dbReference type="STRING" id="1392250.A0A2I2FQ97"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469070"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="358" mass="37749" checksum="B046758FB16094EA" modified="2018-02-28" version="1">MATRRPWPARGPSWGKGCRGGGGPIYPPPYSPYSPGSPPRANWSGGGPPQVHSTRHQTTPGPFAPGTGPPPCLFGPAPTHPRTFCPRHRTAPVPFRSGAHPPRTFCPRHRTAPVPFAPGTTPPDRFASRPRPLASRDHSHPASQGTLPRQLVRQWAFVPYLAPTRQAPSTSLYSPQAPSAPTGLAVGHPRSIRPGTRPPPDRPRAFSVRRPPAPGPFAPGPLPARRGTPQPGDARPGGHMRVRGQGRGPAEKIPVAVSRGAIHKSLPAGQLAQHPAKPRNRPSGRANGSPCGQLAPASARGEGPPRPLGGDLGSQKKEQWSPVGGWPTRYPFPPSKHPALPSTLMGGCYLHKSSQGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRI3</accession>
    <name>A0A2I2FRI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_459720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698545.1">
        <property type="nucleotide sequence ID" value="XM_024851883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRI3"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRI3"/>
    <dbReference type="GeneID" id="36559581"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_459720"/>
    <dbReference type="OrthoDB" id="5284712at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB43243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="546" mass="60247" checksum="0804278974E391DA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRR0</accession>
    <name>A0A2I2FRR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_441735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698603.1">
        <property type="nucleotide sequence ID" value="XM_024850388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRR0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRR0"/>
    <dbReference type="GeneID" id="36558087"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441735"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="280" mass="31537" checksum="DE118FAA44241276" modified="2018-02-28" version="1">MSSPLSQSTTARDEEVLSLDLEENDYLYRIKRDNRIVYVSILDGDLIPPDSRTDSFPILSHLRKLPKWDEEWTTLTVRRASPGSTDSIESTADEFPPHGLDLAQLDLSPVVFYNFLDLEFIARVSDRISRVKCHHTGETRILKIARFAHEIPALQREVSIYSVLAASGFPLSPRVVGYVYEGTKSRTVGFLMEEIEGVVPGIQHLDECRKTVGLLHAHGVVHGDLNRYNFLVDGDRARVFDFEVAVVQRDGDVAAAEEEMDSLEARLRDETGVGKRWLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSD2</accession>
    <name>A0A2I2FSD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mitochondrial outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_369685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698835.1">
        <property type="nucleotide sequence ID" value="XM_024844922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSD2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FSD2"/>
    <dbReference type="GeneID" id="36552622"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_369685"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="225"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB43533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="295" mass="33343" checksum="DD04CDB256E2D95C" modified="2018-02-28" version="1">MPNEGRDPAGQEPSNSVSRARDYFSIPAPIKRIFDQFPLVTLPPNDLPQRTGTSRRGNSLFVFTDAAGARRGRPSFNPQCLKWQAYLKFVGIDFDIVTSNNHASPTGALPFLLPAQSLQANAPIPSNKLQKWAIEQVHCEEEQQLDVRFEVYASLLDHRIRNAWLYSLYLDEANFEAVAKRLYVKPATTNSLVRATLSLQLQQAAREEILKSSQYIDVSALEAEAADAFEALSTLLGDQLHFFGRSNPGLFDASVFAYTHLILDEGMGWKRNRLGQLLQQHENLVQHRERLLKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FSF0</accession>
    <name>A0A2I2FSF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_368604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698862.1">
        <property type="nucleotide sequence ID" value="XM_024844871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FSF0"/>
    <dbReference type="GeneID" id="36552571"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_368604"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="10"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="789" mass="87465" checksum="413E8DF7D394E9AB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTF1</accession>
    <name>A0A2I2FTF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699183.1">
        <property type="nucleotide sequence ID" value="XM_024850287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTF1"/>
    <dbReference type="GeneID" id="36557986"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441326"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014143429" description="Secreted protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11727" checksum="BA3628FACEB6C64A" modified="2018-02-28" version="1">MAAFLRLIPLFGSLRFLVFSCVLLCFCSLGVGSDHGAGCSDRVPMDGVQVYPPLSTMFQQAFSSGFRYTGQREKKKEYHYARRTAPGVQRIEHRRPEVLRPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTY5</accession>
    <name>A0A2I2FTY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial protein sorting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_441526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699378.1">
        <property type="nucleotide sequence ID" value="XM_024850332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTY5"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTY5"/>
    <dbReference type="GeneID" id="36558031"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441526"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="189" mass="21465" checksum="D4A81C1B0DF6828D" modified="2018-02-28" version="1">MKVFSSTCTFDYSWEEVSTANWRKYCPWNDKSPHVVAVDTLSRSVDSTTGILRTERLITCDQSVPQWVLSLFGGSATSHVYEISYVDPISKKVTMCSSNLTWSNVLNVRETVTYQPTSAEPTSTTSFNQEAKITALCGGWQKIKNKVEEASVERFSQNAKRGREGFEAVLEMSRRVFGEQREREQQLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU75</accession>
    <name>A0A2I2FU75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_467934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699502.1">
        <property type="nucleotide sequence ID" value="XM_024852505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU75"/>
    <dbReference type="GeneID" id="36560203"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_467934"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="539" mass="61008" checksum="BE46D334479FBCF5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUJ1</accession>
    <name>A0A2I2FUJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_513521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699612.1">
        <property type="nucleotide sequence ID" value="XM_024855118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUJ1"/>
    <dbReference type="GeneID" id="36562824"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513521"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="335" mass="38652" checksum="FCB4EBA1C6E5E146" modified="2018-02-28" version="1">MAYSTSTTNSPPPFTKLPHSAFLADIENNITLRLLEFNFTLRAQDLVQYRALFSTLPLIGERIFPPYYVAGFRPDGSFQFYPPYQVPQPNKPPPGQSADRIIQSFLGLLSVIYDRRIFFHNMEEVRDVCDMCCDFGLLHEVSDYMNNKEHFPGENQQVLSTIHKAPVMSMILAETLHNRFLYSQAFTLLAGQVVNGGRPRFLSGHSGALDKVSVETRERLLAAYDRTMRRFERTEQRLRKVMAEFRGLLGDFGVDSGNIVFDRFASLWTVFTKNLHRNPNLYRMWREIILAVEQHDGWKRNASPQMIMELAVTKRELAEFLQNALCSSSYLYMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUZ4</accession>
    <name>A0A2I2FUZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_367970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699762.1">
        <property type="nucleotide sequence ID" value="XM_024844835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUZ4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUZ4"/>
    <dbReference type="GeneID" id="36552535"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_367970"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="295"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB44460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="652" mass="73482" checksum="7991E21708A7482E" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVJ7</accession>
    <name>A0A2I2FVJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SnoRNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_393157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699975.1">
        <property type="nucleotide sequence ID" value="XM_024846009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVJ7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVJ7"/>
    <dbReference type="GeneID" id="36553708"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_393157"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="65"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="683"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="814"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB44673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1036" mass="112830" checksum="1C978F624A707F5C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVP7</accession>
    <name>A0A2I2FVP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_265482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700012.1">
        <property type="nucleotide sequence ID" value="XM_024843111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVP7"/>
    <dbReference type="GeneID" id="36550810"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_265482"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="94" mass="10258" checksum="1CDDC1E999591EF1" modified="2018-02-28" version="1">MQALSAAGIAVRSTFLFPLRFLLLFLPLLYSRSTLSIPTPPTATFFTVIIPPAESHFTRNLSFVESSPLNCSLYITRGVYIVCPGEACPGTIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FVV0</accession>
    <name>A0A2I2FVV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Co-chaperone Hsc20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_440008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700062.1">
        <property type="nucleotide sequence ID" value="XM_024849971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FVV0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FVV0"/>
    <dbReference type="GeneID" id="36557670"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440008"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="94"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB44760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="278" mass="30898" checksum="AEE900DF1795E941" modified="2018-02-28" version="1">MPTSFRPQRLLQRLSLSGPARRPRTTSSVARGACIACQLRSQSQSSSRPTSRLPDTRHLTSPLRRRFASTSPASNDSGAPAGPESRGIAPDITNHYTIFRQTLPSGPPPGSPFDISLGDLRREFLQLQNVSHPDKYPPGEAKRRAEAFSTLINEAYRTLADPLLRAQYLLREMHGIDVTAEDGAAKHALDAQTLMEVMEVQETIEEVSADPNAEAKIAELKKENAVRVESGVRELAGAFDREDIETARTECVRLRFWYNVGEALKEWEPGMTELRLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW00</accession>
    <name>A0A2I2FW00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_449884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700096.1">
        <property type="nucleotide sequence ID" value="XM_024851077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW00"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW00"/>
    <dbReference type="GeneID" id="36558776"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449884"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB44794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="524" mass="57993" checksum="3DAE9F4308F25A98" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FW93</accession>
    <name>A0A2I2FW93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Got1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_440105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700200.1">
        <property type="nucleotide sequence ID" value="XM_024849995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FW93"/>
    <dbReference type="STRING" id="1392250.A0A2I2FW93"/>
    <dbReference type="GeneID" id="36557694"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440105"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB44898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="139" mass="15117" checksum="DB0BCE355A29298F" modified="2018-02-28" version="1">MPNMWLSDNQKIGVIFCSGGGLFLFGGVLMFFDRSLLAMGNILFLIGLTLIIGLQKTIAFFSRRQKLKGTAAFASGILLILLRWPLTGFLIELYGLFILFGDFLITIGQFAGNVPVVGPYIQKALETLAGGRSNAELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWA4</accession>
    <name>A0A2I2FWA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative unsaturated glucuronyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_270575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700222.1">
        <property type="nucleotide sequence ID" value="XM_024843132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWA4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWA4"/>
    <dbReference type="GeneID" id="36550831"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_270575"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="366" mass="41614" checksum="B7401B1B6AAE028C" modified="2018-02-28" version="1">MASKPSPPQVREKVDLLINNLVNIKDATGQFLLRLQDGRVIDTKSWHGWEWTHGIGLYGIWKYYEMTGNPDLLRIIEDWFAARFAEGGTTKNINTMAVFLTLAYVYEKTGNVTYLPWLDAWAEWAMHDLPRTRYGGMQHATYLTENYQQLWDDTLMMTVLPLAKIGKLLNRPAYIEEAKRQFLVHIKYLFDTRSGLFYHGWTFEDGGHNFADARWARGNSWITIVIPEIIELLDLQPSDPLRIHLLDTLEAQCESLQRLQDPSGAWHTLLDHADSYAEASATAGFAYGILKAVRKRYLGPQYREVAEKAITSVLGYVDAAGELQNTSFGTGMGDSLEFYKLIPLTAMPYGQAMAIMALGEYLRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWC8</accession>
    <name>A0A2I2FWC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_449991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB44924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700226.1">
        <property type="nucleotide sequence ID" value="XM_024851082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWC8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWC8"/>
    <dbReference type="GeneID" id="36558781"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_449991"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB44924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="269" mass="28370" checksum="3EDF3881D07AC95B" modified="2018-02-28" version="1">MALPAWGLLKGKTAAITGGTTGIGRAIVLEFLRQGCNVAVNHLGLSKDEAHRHSLLQEARAMGKEGAQVGRILELAGDVTRPETSQNLIEEAVAQWGQLDVFVANAGVFKQAELLKIEPALLDHSIDVNVKGTFYSCQAAARQMVRQGRGGSIIAISSVSALVGGGLQTHYTPTKAAVLSMMQSMAISLGKDQIRCNALLPGTINTQLADHDMKNPTKKAALEARIPLGRIGSPEDMAGPAVFLACEPMSRYVNASGLLADGGMFSNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWV1</accession>
    <name>A0A2I2FWV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P170DRAFT_458645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700389.1">
        <property type="nucleotide sequence ID" value="XM_024851815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWV1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWV1"/>
    <dbReference type="GeneID" id="36559513"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_458645"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PLB45087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="587" mass="65487" checksum="5CAA09EA21CA4249" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWV6</accession>
    <name>A0A2I2FWV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_440198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700348.1">
        <property type="nucleotide sequence ID" value="XM_024850023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWV6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWV6"/>
    <dbReference type="GeneID" id="36557722"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440198"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB45046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="47758" checksum="DEB6A1F600A5CC4F" modified="2018-02-28" version="1">MERILSLFCSALCLSSDQYDLLEQDISGYDTDTFQCDEKKPICTNCSQHSIECDFSSPPVLPSQGSAASSPPTRRYRFKQSKYQPLAVPSPSDSNQSPDSTSTGVQCDLSASHHASGGISFADLELFHQFITATYITFGDVTEKHRAIWQVHVPRWGISFPSIHHLNLAIAALHLAHENPDRRDEYVAKADSHFTFGVRSVTNILSKLDSDNCQMVYLSAVLICFIYFARGPRRGEYLVFSETGQSEWLVLMRGVRFILFSKPQEVFSGILDPGEQEKPKMTPALETELLEQKVHLAAARQFLEESVPESERELYVSGMEKLMVSFEEMHNVRSIKGDGACLMPAVIGWIYRLPDTFVQRLEDKDSFALVILAYWSVMLKYMTPTWFMEGWDVHVISGIRNSLRVDYHQWIEWPVRTICGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXB2</accession>
    <name>A0A2I2FXB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pachytene checkpoint component Pch2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_513301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700577.1">
        <property type="nucleotide sequence ID" value="XM_024855094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXB2"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXB2"/>
    <dbReference type="GeneID" id="36562800"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513301"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="176"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB45275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="459" mass="51189" checksum="A649A3B1E23970ED" modified="2018-02-28" version="1">MDCFSGTETASKPVLHVEARVKTNGDGFIIRTDLVRDEVTQWLAENFVVLSLGQEITAFENFRGPHRQFMDCVLVTDCAGGNTESGAYWLHQVELDVQAYQLYTPYEQESSQTTDDFINTSEDTSMAKVVTLPCKELDGLWESLHFDEPIQTTIIRAITRMVSFSSQKLDQWTISWNRLILLWGPPGTGKTSFCRGLAQKLAIRLGKQYPRSKLVELNAHSLGSKFFGESGKIVSKTFEGIELLLEAEEDTFVYVFVDEVETLAARRERALACNEPFDAVRAVNALLTGLDRLKKYDNVIVICTSNLVTALDQAFLDRVDIKQFIPHLSSRTIYGIYKECLQELSRRGIIKGMSFDVIQESPGDPFTALQYVERPAESLALPAFDEMLLHYQIFVDAIPKQMADAAAESVGLSGRIIRRLPALSLVMYSPGSAGCGIRAALQALRMGIASERQAKAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXF7</accession>
    <name>A0A2I2FXF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_392079</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700631.1">
        <property type="nucleotide sequence ID" value="XM_024845957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXF7"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXF7"/>
    <dbReference type="GeneID" id="36553656"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_392079"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="180"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB45329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="417" mass="46860" checksum="432DAB42AB851F1F" modified="2018-02-28" version="1">MSDAKPRVCLAYSGGLDTSCILRWLIEEGYDVVCFLGNVGQEEDWAAVEEKALKIGAKKMIIEDLRREFVTELCFPAIQCNAIYEGRYLLGTSLARPVIARAQMRAAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKFFKRFAGRNDLLDYAAQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPDHTPPSDMWTMTNDPLNAPNEPTDISIEFEKGIPVKVTTPEKQYTDPVELFNALNKLGYTHAIGRIDIVENRFIGLKSRGCYDSPAMTILRDAHLDLEGLVLDGQVRALRDQFVTHNWSIQLYNGYYFSAEREFIENSLVYSQKRVNGQVRVRLYKGNAYVLGRSSHTEKLYSAEEASMDSLEDFEPTDTTGFVAIQSIRLKKYGLQKAEEGESLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXH4</accession>
    <name>A0A2I2FXH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ornithine carbamoyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_416465</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700637.1">
        <property type="nucleotide sequence ID" value="XM_024847120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXH4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXH4"/>
    <dbReference type="GeneID" id="36554819"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416465"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000017">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="16">
        <location>
            <begin position="39"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="15">
        <location>
            <begin position="198"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB45335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="364" mass="39362" checksum="398179F72074B710" modified="2018-02-28" version="1">MSLNLAVARSGTLRQRLPLNAVRQYSSHATPPTSPFAPRHFLSVGDLSPAEFAALVRNASSHKRSIKSGSIPQNLLGSLTGKTVAMMFSKRSTRTRISTEGAVVQLGGHPMFLGKDDIQLGVNESLYDTSVVISSMVSCMVARVGKHADVADLAKHSSVPVINALCDSYHPLQAVADFQTIYENFTPKAHHLTSLGLEGLKIAWVGDANNVLFDMAIAAAKMGVDLSVATPKGYEIPASMLQIIAEAGKTAPKPGKLIQTNVPEEAVKDADVLVTDTWISMGQEAEKIQRLKDFEGFQITPELAKRGGANEGWKFMHCLPRHPEEVSDGVFYSNRSLVFPEAENRLWAAISALEGFVVNKGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FYQ1</accession>
    <name>A0A2I2FYQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_478706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701072.1">
        <property type="nucleotide sequence ID" value="XM_024853587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FYQ1"/>
    <dbReference type="GeneID" id="36561285"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478706"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="166" mass="18506" checksum="4EE46993F8B85722" modified="2018-02-28" version="1">MHDHKANDTKKPEEGNWSERPPDTMRVIGPGGAIIRAATAKQARSTGPEKTGKLWGSPYDDDDIFFLLVGPSLQGPQRLACESACRTLQWTQWTGARSLTRTFDDFHPFSSVFLARIRITSWPVHRQSPVPRPGGLCGDSGILVRVSMRPSLCRGFWLWIGAHPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZR0</accession>
    <name>A0A2I2FZR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_439793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701419.1">
        <property type="nucleotide sequence ID" value="XM_024849923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZR0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZR0"/>
    <dbReference type="GeneID" id="36557622"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439793"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="280" mass="30351" checksum="34A59370044954B9" modified="2018-02-28" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNSGVTALGIKATNGIVLATEKKSSSPLIDPPSLSKISLITPDIGMVYAGMGPDYRVLVDKARKVSHTGYKRIYNEYPPTRILVQDVARVVQEATQSGGVRPYGVSLLIAGWDEGVEPESEQAAKGEDEDPESRKATGKTGGILKGGPSLYQVDPSGSYYPWKATAIGKHATSAKTFLEKRYTEGLELEDAIHIALLTLKETIEGEMNGDTIELGIVGPPADHLLGYEGVEESRGPRFRKLTKEEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G074</accession>
    <name>A0A2I2G074_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative fructosyl amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_439893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701575.1">
        <property type="nucleotide sequence ID" value="XM_024849940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G074"/>
    <dbReference type="STRING" id="1392250.A0A2I2G074"/>
    <dbReference type="GeneID" id="36557639"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439893"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB46273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="428" mass="47408" checksum="C4BB2348C6AC66B7" modified="2018-02-28" version="1">MNLDTKILIVGGGAFGTSTAYNLAQRGYRSVRVLDRYAAPSLDAASTDISKIIRSDYNEPLYAAMGLESIAAWRTWDMFKDLYAVPGWILSAANLSIPFVEGSIETSTRLGVQGLERVAPDQIRAKFPQITGELDGWEVNVWNPTAGWAKSGEALRRMALAAQANGVQYISGDRGYVRKLVFSTEGCRGVVTQDGTTYEADVVIVAAGAWTPSLVDVGGQLTAKGHAVAHIQLTPDETRHYRSLPILDNLELGYFLPVQEDGIFKLAHSQFITNTETDPVSGITTSIPHTFVENPRDDLPPEIERTMRRNLRRVFPELADRPFCFTRLCWDADTADRHFLVTPHPDLQGLFLATGGSAHGFKFLPVLGRYIADALEGTLDQEILHQWRWRPGITVSADNLAHLDPEIELNSLRGWRCRREEDGGLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G0V4</accession>
    <name>A0A2I2G0V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_477384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701805.1">
        <property type="nucleotide sequence ID" value="XM_024853454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G0V4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G0V4"/>
    <dbReference type="GeneID" id="36561152"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477384"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014143408" evidence="4">
        <location>
            <begin position="24"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="5">
        <location>
            <begin position="115"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="694"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB46503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="818" mass="90806" checksum="C32FBE7C81798273" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2A6</accession>
    <name>A0A2I2G2A6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_438724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702312.1">
        <property type="nucleotide sequence ID" value="XM_024849670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2A6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2A6"/>
    <dbReference type="GeneID" id="36557369"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438724"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21297">
        <property type="entry name" value="CH_FIMB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="135"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="284"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="408"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="533"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB47010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="644" mass="72175" checksum="A1CA9D1CA1884EA9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2K6</accession>
    <name>A0A2I2G2K6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_438831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702415.1">
        <property type="nucleotide sequence ID" value="XM_024849693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2K6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2K6"/>
    <dbReference type="GeneID" id="36557392"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438831"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="346"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB47113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="546" mass="60371" checksum="901255B9FBFE3C03" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2W6</accession>
    <name>A0A2I2G2W6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GATA-type transcription factor sreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nitrogen regulatory protein areA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Siderophore uptake regulator sreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_428426</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Major nitrogen regulatory protein. Positively acting regulatory gene of nitrogen metabolite repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702518.1">
        <property type="nucleotide sequence ID" value="XM_024847840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2W6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2W6"/>
    <dbReference type="GeneID" id="36555539"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_428426"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034757">
        <property type="term" value="P:negative regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000039">
        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="17">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="17">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="395"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB47216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="567" mass="60964" checksum="514B34C0506D8FE6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G350</accession>
    <name>A0A2I2G350_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_362036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702600.1">
        <property type="nucleotide sequence ID" value="XM_024844500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G350"/>
    <dbReference type="GeneID" id="36552200"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_362036"/>
    <dbReference type="OrthoDB" id="4202165at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="287" mass="32884" checksum="AC95228C4108E01C" modified="2018-02-28" version="1">MALPLQELTSPPQEKASPLQEVISPPQKETSPPQEEISLLPRETSLPQDEISLPHREETSLTQHHAPIISVAAKALAKKDIPVVEYGQQIQWRYGDPVVLLRVEWAVPDELLSIASETLSDLDFPRVPPSTEAVVYFYGEWERACIIHRLGQGCPVYLYSRSFIGLALQDTCQVTSTFDRTLKILTPKPPKYMVSLLRHLLSHPLDVFRLRVKDDLLSFICFYILREKPLNTKVEGWDDESEEDYQKRVGEALKEMETWDWGAGREEYLRISESVLRDARTIDQLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G359</accession>
    <name>A0A2I2G359_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="3 15">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_457639</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="3 15"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702613.1">
        <property type="nucleotide sequence ID" value="XM_024851731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G359"/>
    <dbReference type="STRING" id="1392250.A0A2I2G359"/>
    <dbReference type="GeneID" id="36559430"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_457639"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021162">
        <property type="entry name" value="Dot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017570">
        <property type="entry name" value="Histone_H3-K79_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 15 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="18">
        <location>
            <begin position="178"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="305"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="390"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017570-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PLB47311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="499" mass="55927" checksum="0FA8FA88DB582BAD" modified="2018-02-28" version="1">MGFFDHLQKGGAFSLQPKKTQIRKVVQTRPAPPSRSSSLTPATSSRISPSKKARSSESRSASRDPDHLTSKRRLGTPRQSRKRPTPEQRLSSDEDESDTDASFEVRKRARTGDSAEPDLERRVRSLKAFSEDHVKPLPMVHAADITSIQKAGNFKPAFGEKVQSTEIALQYPSASPKERFNLVVPRDNDDFKPIDDIFSVVDTVSQTHIPEDEADQFNNESTGIKRRLRRALAQGSEKDFRQVVADYNNAIDRLRRSGSIAKKLDSTHRLNLPLVERILTQIYSRTVSPRVESLRQYENGTDNVYGELLPRFISTIFKETGLKSGQVFVDLGSGVGNVVLQAALEIGCESWGCEMMQNACELANLQQAEFKARCRLWGIAPGKTHLVSGDFLREQSIIDVLKRADVILINNQAFTPQLNNELINHFLDMKEGCQIVSLKSFVPAGHKIQSRNLNSPINLLKVKQRNYWSNSVSWTDVGGTYFIATKDSSRLKAFVEDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3D0</accession>
    <name>A0A2I2G3D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_478236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702688.1">
        <property type="nucleotide sequence ID" value="XM_024853541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3D0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3D0"/>
    <dbReference type="GeneID" id="36561239"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478236"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="369" mass="41337" checksum="67F30D09A541036A" modified="2018-02-28" version="1">MVEFGSITPAMPPPPGQSSNFINPEYIGTKFLVVNCVFLPLSAIALLVRTWTRLFIVRSFRSDDYLMIFAWILSCVLTGVTLEMLNRGLGRHMWDVHATDYSPWFLKLNMISAIFYCAATGFTKVSVLIFYVRIFPTRTFHICVWAIAAIAVLYNVASVFANFLGCTPIAKTWDMTITKGTCMNRPVFYFANAGLGIFTDFATVLVPIPWLRRLQMPLRQKIAVALILATGCFVGIVSCVRLATLYDLLKSPDLTWATTDALMWCTIELNLGITGGCVTAMRPFVRRYFPRLLGLSSAENTSRSKKYAHPLGSIPRSQPDFATPRDHQYSTTAHAHNDSEEYILSPSPGPKEDGILRTVEFDIENSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3V2</accession>
    <name>A0A2I2G3V2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_456412</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702866.1">
        <property type="nucleotide sequence ID" value="XM_024851617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3V2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3V2"/>
    <dbReference type="GeneID" id="36559316"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456412"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000019">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF49">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="17">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB47564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126383" checksum="0970874ACB24D6F9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G490</accession>
    <name>A0A2I2G490_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_465282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702981.1">
        <property type="nucleotide sequence ID" value="XM_024852310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G490"/>
    <dbReference type="STRING" id="1392250.A0A2I2G490"/>
    <dbReference type="GeneID" id="36560008"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465282"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="469" mass="52054" checksum="ADD88B2938EBD1DC" modified="2018-02-28" version="1">MPGVPTSRGCEACRKQKKRCDQEQPACSRCARLGIPCIGGGARRFKFTENRTPDASASALQKQQGGGARRPPSVAYVAPARALCGDAARLQASLINMLEVKDARYNLGYYGVFFAQLPCRVGVHPALDAAVAAVTHSAPCLFKQESSSLALEKYGRALYMLRLSLQDGKVDLGVETLCAIYLLWISEDWITGNSEGHLMHTAIIALILKNLARKPDLDDFQIQLLRTLCMAVLVHSVFDPRVHLDPHVIHRFLINGPRLPANHQLLSPFETLTVPNFARIPRLIHHPESHTTQLLTVYSHMASDFPKLRAIARSPTLVARPNASLVAIRAQINYQTAYGLFLAVMTMLNRLCWVLGSERGVLDRELDVLVEEIQGLGERGLKLRPLGSHYMPMSLSAAWAALTFDEGGRERVEEIERLAGEYCSSESLMEAWRARGAQTRRQFERLREKMDESGQVGLERGRVGVVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4B1</accession>
    <name>A0A2I2G4B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_409935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703001.1">
        <property type="nucleotide sequence ID" value="XM_024846823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4B1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4B1"/>
    <dbReference type="GeneID" id="36554522"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409935"/>
    <dbReference type="OrthoDB" id="3636394at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF23">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11B (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25891" checksum="43AD2F706D45B004" modified="2018-02-28" version="1">MSLIQPPSKITQFANFTRSSAGLEKTLRLIQAVAQIVADVAADRTVASQWGLAKGQLALSRRFFRFFNFIDCFDRVAGLLGGRVGGNEGALTLLIELARWSCLGGYFLLEDLTILHAMKIHPPKWTWNVTVLEEAYKLWFYALSLSLVGAVWSLLFTVSGPSTGPGKGGKKGGKKNGKVAGTSNQALRRTLLKRIVVDGCDLLIPGVFLGWLVVGDAVVGAAMVVSTLLAGRDVWGRVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4E7</accession>
    <name>A0A2I2G4E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P170DRAFT_465328</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703053.1">
        <property type="nucleotide sequence ID" value="XM_024852314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4E7"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4E7"/>
    <dbReference type="GeneID" id="36560012"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465328"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="237"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PLB47751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="592" mass="67864" checksum="5B303E2E5B5AB1B0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5A1</accession>
    <name>A0A2I2G5A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LON-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_340865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703346.1">
        <property type="nucleotide sequence ID" value="XM_024843392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5A1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5A1"/>
    <dbReference type="GeneID" id="36551092"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_340865"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="8">
        <location>
            <begin position="265"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="584" mass="65356" checksum="8E1BC69C2548BB37" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5E1</accession>
    <name>A0A2I2G5E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_360330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703393.1">
        <property type="nucleotide sequence ID" value="XM_024844407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5E1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5E1"/>
    <dbReference type="GeneID" id="36552107"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360330"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34026" checksum="4E506C17748856AE" modified="2018-02-28" version="1" fragment="single">ESFLIFSQPIPSANLGIIDSRASSVEVSIHGQDYTVHQSPTLLSSARAGGTTGAVLWKITPLFAEWISTRSSNPLWAQSLLSSSSTVVELGCGISGLMALTLAPCVRHYIATDQEYVQRLLRENLETNASVSSSARTTASAKSKGKKQPPKQKAKSKPTSSSPTPANITFTTLDWETDIPSSLKDSIEIDAPSDDDQDAEDKGFDLLVSCDCIYNEALVAPFVRTCADICRLRPVYRESGSGSGDGDGSRPPTICLIAQQQRSPDVFEAWLRETMRFFRVWRVSDEIAGERLRLGSGYLVHLLLLREDAAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5M7</accession>
    <name>A0A2I2G5M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_476825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703484.1">
        <property type="nucleotide sequence ID" value="XM_024853383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5M7"/>
    <dbReference type="GeneID" id="36561081"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476825"/>
    <dbReference type="OrthoDB" id="10338638at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="201" mass="22525" checksum="B30B5DA48BCFA5D0" modified="2018-02-28" version="1">MPALLDLDIQFDDGFTLNEEPLKNWDCTVLVDFTALPSLSRLGLEHLHLGNMIFCGHPDSLRTFEVNLSKGELSDILSIIGIRLEQLIVGWSHVTCQALTVDLLSLKKVHLKDSSGIFPFLLENELPALEEIILETPFQGEFGGFDFRRAFSDDNKARPDVMQWTKNNGSLASFFHLGKQIPCGDSSDSYSLVDQILWTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G5U0</accession>
    <name>A0A2I2G5U0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_437910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703542.1">
        <property type="nucleotide sequence ID" value="XM_024849471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G5U0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G5U0"/>
    <dbReference type="GeneID" id="36557170"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437910"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB48240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="138" mass="15862" checksum="ACDE2F8D08AD16DC" modified="2018-02-28" version="1">MMQTRMLSKEDEVAVGGGDDNEVRREDQEKINRFSRLHQRETVLEDLLKAKQKDKEDLEEVSTELELADEDELVPYKIGDSFFQLPLEEAQSLLSSSTEQIDTEVSGLEDKLGDLREELQQLKVALYARFGRSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6D3</accession>
    <name>A0A2I2G6D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_465791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703731.1">
        <property type="nucleotide sequence ID" value="XM_024852353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6D3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6D3"/>
    <dbReference type="GeneID" id="36560051"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465791"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014126860" evidence="3">
        <location>
            <begin position="20"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="118"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB48429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="570" mass="61387" checksum="27C1E208D931F7AA" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6D6</accession>
    <name>A0A2I2G6D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_448142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703748.1">
        <property type="nucleotide sequence ID" value="XM_024850946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6D6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6D6"/>
    <dbReference type="GeneID" id="36558645"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448142"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27485" checksum="14A3C09822459171" modified="2018-02-28" version="1">MPAQDKYTDPELRDEVKEEVKQSDKGGAPGQWSARKAQFMAAEYKKRGGDYNTSKEEGEKKDEAQRSLNQWTKEEWQTKEGSGSAKQEDGTEKRYLPKKAWEKMSDEERRETDEKKQEGSKEGKQFVSNTEKAQRERKEAKEEVEEENEAEDEDHGKDEKLSRSGDDGSDDGDAQGDDQVEDGKADSQDEAKLQNGRQGKKNEKDKKDQKAEAGTKRTSGQDKTPTKKPRTRQDSKAENGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6J6</accession>
    <name>A0A2I2G6J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_360708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703798.1">
        <property type="nucleotide sequence ID" value="XM_024844428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6J6"/>
    <dbReference type="GeneID" id="36552128"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_360708"/>
    <dbReference type="OrthoDB" id="5371818at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="197" mass="22585" checksum="9E49F7F5F9D29DC9" modified="2018-02-28" version="1">MVQLNTPVQVIPPAKLAHVVLRTRPESYDRLIEFYKTFLGGRTSFESESLTLVAYDDEDHRVAIVKIPGLAPKDPRTCGLHHFAFTFNTLDDLMLAYRQRKSLGIEPVWCVHHGPSISMYYRDPEGNQLETQVEVLNSTEESVAFMSSKEFKENPWGVDYDPEHIIAELKRGVDPKSFYPRPYIGVREMESVPLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G741</accession>
    <name>A0A2I2G741_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_358938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703992.1">
        <property type="nucleotide sequence ID" value="XM_024844323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G741"/>
    <dbReference type="STRING" id="1392250.A0A2I2G741"/>
    <dbReference type="GeneID" id="36552023"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358938"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF7">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="126"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB48690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="448" mass="50071" checksum="51CDB2D55AA7F68C" modified="2018-02-28" version="1">MDYNDPNHLLAAAKKLRAEFLQQVRTTSVSDAQAATLRDDPVKGPLWVAKFTVPKPTEDTSRELLLSLVDDLNDRNIFYDRPDSQPLQFEWVGYRHNVEKNTPEPSISESEKFQRLVAETKQPTVIFYIYGGTFVLNTPSCYRRTTGFLAQETGSKVLMVHQRLAPQSPFPSALLDVFQAYLALLAPPPGALHKAVSPSSIVIAGDSSGTCLAFGLLQVLLRLQRSKKTIVFHGQTIDPTVPAGLALVSPIADQTGCLPSYERNVKTDIHPVPMENLHYLQPDFPTCALWPTRPPRSNLYCDGALLAHPLVSPVASEDWTGSCPIWMASGEEQATDPARLIAQVANSQGVSVTYDEYEKMPHTFFFFYRQAPQTAKIMADWAQAILGFCVGERPTSCVRYIRAKGLVAEPQDMNQLVPFTVAEVRELMWEKNRKMKVPPFHRDPRSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G744</accession>
    <name>A0A2I2G744_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N2227-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_446534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703980.1">
        <property type="nucleotide sequence ID" value="XM_024850806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G744"/>
    <dbReference type="STRING" id="1392250.A0A2I2G744"/>
    <dbReference type="GeneID" id="36558505"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446534"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014111479" evidence="1">
        <location>
            <begin position="19"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="426" mass="48917" checksum="D193263C4CD03491" modified="2018-02-28" version="1">MLRWIALSLAFLVCLACAKQAIDVSPRLDQITHVFVTNITLLDAAPSPRHDEEYARLQHRLERSRGKWDSSHARHRLLTALHGYMRYKERHLVETKKWRDMYKNVSKKQRSLVESTIHYTRKLNTIEHLLEANEKLAKDIVTQGLQFYNVSQSELDEFIRHQERQSQSTDRTSVAQAMKHFVRDWADEGFDERQESFPCVLKALKSVPKPSDRPLRVLVPGAGVGRLAHEIDELGGFEVTMNEWSMYMNLVYRYLVSLSTPNSVSFHPYIDWWSHHATTSDLQRSVVFPDQVVDPSSVLLVEGDFTTAFTEETGKYDVIVTLFFIDTARNLVSYLENIHRLLRPGGTWINLGPLLYGTAPFIQLSLDEIVALSERIGFRFEEMEASCGDITLPNCPVRGLEVAYGRNGKGLSKNAYQAQFWQATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7I4</accession>
    <name>A0A2I2G7I4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_358130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704115.1">
        <property type="nucleotide sequence ID" value="XM_024844261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7I4"/>
    <dbReference type="GeneID" id="36551961"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358130"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="115" mass="12631" checksum="C2847C27745CB754" modified="2018-02-28" version="1">MSSELSVALYKGGVYLHCALFIDGPGPKGKVILHATGSTGRYKFEQKESDPRQSAHLVELIYLCHVKDSDIPAIEDAGKNAVIHNEFPGYNCQNYVIELLEDLGAKEIINGNDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8N6</accession>
    <name>A0A2I2G8N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_436854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704541.1">
        <property type="nucleotide sequence ID" value="XM_024849241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8N6"/>
    <dbReference type="STRING" id="1392250.A0A2I2G8N6"/>
    <dbReference type="GeneID" id="36556940"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436854"/>
    <dbReference type="OrthoDB" id="5597581at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB49239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="295" mass="33096" checksum="F422723A2984B910" modified="2018-02-28" version="1">MPKDKERSMNPAAAQRKLDKQKNLKKSKADALARRNEKLARRNPERIQRQINDLKSVEETGQQLRPRDKELLGALERDLRAVQKAREALGDKAPKFEHSGPRRDGRGDGANVLGKRRRDGHGHGHGGGFGQDSDGSETDEEVRRIPMPRDTPPPIPRQYQQRRRDGDSGPGGPRGPHALPAKPPVTESKTVYEAQPEIKDLRQEAINKFIPAAVRAKQESIRGQGKLLEPEEMDRLEKAGYNAGPAQTGGDDGTNQPGGEDEDDDDTQRRLQEEERRFNQELRSVQIEEVEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G900</accession>
    <name>A0A2I2G900_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_509887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704615.1">
        <property type="nucleotide sequence ID" value="XM_024854716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G900"/>
    <dbReference type="STRING" id="1392250.A0A2I2G900"/>
    <dbReference type="GeneID" id="36562422"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_509887"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014140689" evidence="3">
        <location>
            <begin position="19"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="88"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="420"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="549" mass="61042" checksum="077B0894522E7714" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G903</accession>
    <name>A0A2I2G903_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like polyketide cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_475651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704656.1">
        <property type="nucleotide sequence ID" value="XM_024853281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G903"/>
    <dbReference type="GeneID" id="36560979"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475651"/>
    <dbReference type="OrthoDB" id="2820488at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014126846" evidence="1">
        <location>
            <begin position="17"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="158" mass="17617" checksum="424F3C9F1C8727C6" modified="2018-02-28" version="1">MHFNLPLAFLAPLALALTLSHRSYANTTPLSNTHSSLLSEQHIVLTEFSRVFYTEKNVPLAFNTYVSESYFQHNPNILDGREAAIDALSPLFATPGAEFQIINLFVGEGFGLVHVRAITPGQNDSSVMDLYRFRGVEIVEHWDVGQVVTEGVNPHPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9F9</accession>
    <name>A0A2I2G9F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Activator 1 37 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_357373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704818.1">
        <property type="nucleotide sequence ID" value="XM_024844215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9F9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9F9"/>
    <dbReference type="GeneID" id="36551915"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357373"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="60"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB49516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="352" mass="38978" checksum="BA42B037F8699A3D" modified="2018-02-28" version="1">MAQAESSASAARNGLKAVTTGAPPDYELPWVEKYRPVFLDDIVGNTETIERLNIIAKDGNMPHVIISGMPGIGKTTSILCLARQLLGDAYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLSPGRHKIVILDEADSMTPGAQQALRRTMEIYSSTTRFAFACNQSNKIIEPIQSRCAILRYARLTDTQVVKRLKQVCEAEKVEHTEDGIAALVFSAEGDMRQAINNLQSTWSGFGFVSGDNVFRVVDSPHPIKVQAMIKACWEGKVDAALESLNELWNLGYSSHDIISTMFRVTKTIPTLSEHSKLEFIREIGFTHMRILDGVQSLLQLSGCISKLCKINMKPQLFEPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9N5</accession>
    <name>A0A2I2G9N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_510115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704886.1">
        <property type="nucleotide sequence ID" value="XM_024854744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9N5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9N5"/>
    <dbReference type="GeneID" id="36562450"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_510115"/>
    <dbReference type="OrthoDB" id="5417628at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="569" mass="62671" checksum="6F46C3A06A905DE1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9U5</accession>
    <name>A0A2I2G9U5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_426524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704948.1">
        <property type="nucleotide sequence ID" value="XM_024847710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9U5"/>
    <dbReference type="GeneID" id="36555409"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_426524"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32399" checksum="FBE9C1085F7181BA" modified="2018-02-28" version="1">MSYQYPPHPPHPPPPPHPSHPSDPLLPPNPPNPPTTNAQNTLDPESWVKFVVGSSRVKFHVRVRLLSWLSPTLNRDMLSFQSGNKETCPSLNLPPVGEDTFVRLCEFAFLKTNYSVPEPRYKLPLPADQDGTGQSFLSNTSRFEPKELTPAELLEKRNLAHADRLALRELCPEIPMDCLREHEPYRNTPSQDFSEVFKAHADVFIVAQIYEIERLKIVVLNNLEGAFVTLTMHPLILENLANLAWYAYRFTPRGAPDQRSLFRVVDCFLVWDISMGRCQCMSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9U8</accession>
    <name>A0A2I2G9U8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_409219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704959.1">
        <property type="nucleotide sequence ID" value="XM_024846762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="36554461"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_409219"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1839"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1432"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1621"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="954"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1621"/>
            <end position="1633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB49657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1869" mass="210968" checksum="92EFB77451007C0B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAF2</accession>
    <name>A0A2I2GAF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_193072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705154.1">
        <property type="nucleotide sequence ID" value="XM_024842712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAF2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAF2"/>
    <dbReference type="GeneID" id="36550410"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_193072"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51260" checksum="D0AFE1859B7DC132" modified="2018-02-28" version="1">MGDPTYVEELSPLDLSMPRTYISVVLIFEQPGPNAKITQVLQNSLGRLSKQVPWLSGKVFPKASSGKSASSLEIRWNANDTPTLVDKGTIAASYKHTSSHGMPADAISSDVLPVPSVIDDALLAEGVPVFATSIFRFADNALGLCISLHHNAVDGTGLSSIMRQLSRNITDPGFTFSGSSQGRTDRFSKALALDLQETSSISSESLFSLHPEYSRNPPSLPEKFAPSTSKLFTISMIWIDALKELMRKYTSKAPTTNTVLSALIWTTITRIRMQDNPSLGGDMSQLVTAVNGRQRIGTNFSEPDSPFFGNAMFYSLSKLPADILAASDQTPVRSLAQICDHIAQSQYAINSRHIAEVYQLIEGVEDCRSLFPGWDLFGSRDLTITSWADLELYDLDFGDAMGKPKFVRVPYLEADGVAIVLPRQRAVPHEVLEVMVMLRRDYMDALERDVMWQTIVSIGRRDGNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAH0</accession>
    <name>A0A2I2GAH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_508176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705164.1">
        <property type="nucleotide sequence ID" value="XM_024854539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAH0"/>
    <dbReference type="GeneID" id="36562245"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508176"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="30"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB49862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="423" mass="45099" checksum="30D139AFA5BDAA0D" modified="2018-02-28" version="1">MSMSEKEHTSAETLVTPSEADSGPPDGGLRAWMVVVGGFLTYFVTFGLLNSFGTFQAYYGEDLLTSHSESAISWIGSIQVFLLFIGGVFFGPVFDTKGAKILFVPGTIFFALSLMFVSLCHEYYQFILAQSLLFGIADAMLFYPTISAIPHWFNRRRGLALGIVVAGSSLGGIAWPLILDRLFGTVGFAWALRIVGFISLGLLAPACLMVVPRLPPTKASEVPKAEIAAIFKDIPFILLVAGMLFVMWGMFIPFYYLPLYARQQGVDAAFANDLIAILNAGSLVGRVVSGGLADKMGRFNMAIICSLLSGIVLLCLHVMCTKGSIVTFALLYGLFSGGLISLQSACVAQITNNMQIIGIKIGVMMAVCSVGALTGAPIGGALISTENGKYSGLITFAGVILLAGTMLLVGSRWTLSRNVLQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAK8</accession>
    <name>A0A2I2GAK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_491422</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705204.1">
        <property type="nucleotide sequence ID" value="XM_024854020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAK8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAK8"/>
    <dbReference type="GeneID" id="36561724"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_491422"/>
    <dbReference type="OrthoDB" id="114708at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014121265" description="rhamnogalacturonan endolyase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="292"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="374"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB49902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="547" mass="59284" checksum="6AFABA7067B52DDE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAX3</accession>
    <name>A0A2I2GAX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_508284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705336.1">
        <property type="nucleotide sequence ID" value="XM_024854552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAX3"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAX3"/>
    <dbReference type="GeneID" id="36562258"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_508284"/>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="143" mass="15442" checksum="6664465F73FEDC70" modified="2018-02-28" version="1">MTEPLPVILCGKTEQIGAVVIESLKPELEVVHFILTPEAGVEQIPALLRGEKQVTSTSSLGSHNYERGINAIILGAGYDDQAAQVLRDAARGLKPVPWLRPDTSKPAPPLGPEYGKALVARIKETFVQLRKRGGLDGDAVVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GB85</accession>
    <name>A0A2I2GB85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS aflatoxin efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_404914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705440.1">
        <property type="nucleotide sequence ID" value="XM_024846557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GB85"/>
    <dbReference type="GeneID" id="36554256"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_404914"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF153">
        <property type="entry name" value="AFLATOXIN EFFLUX PUMP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="24"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="535" mass="56886" checksum="DFF2EA2FE607DCC4" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBP5</accession>
    <name>A0A2I2GBP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_405245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705603.1">
        <property type="nucleotide sequence ID" value="XM_024846573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBP5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBP5"/>
    <dbReference type="GeneID" id="36554272"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405245"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="545" mass="61030" checksum="7A2CB89CA9686159" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBR1</accession>
    <name>A0A2I2GBR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF2 family helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_463556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705624.1">
        <property type="nucleotide sequence ID" value="XM_024852177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBR1"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBR1"/>
    <dbReference type="GeneID" id="36559875"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463556"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="384"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="795"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB50322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="945" mass="105326" checksum="635F5C20E3FB0769" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBR4</accession>
    <name>A0A2I2GBR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_435515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705615.1">
        <property type="nucleotide sequence ID" value="XM_024848953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBR4"/>
    <dbReference type="GeneID" id="36556652"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435515"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="95" mass="10225" checksum="4A778B8F9D45FB8D" modified="2018-02-28" version="1">MSCRLHFLHLDGRDRDSSACLPGCVSVFVSFASVQTRVSGGIPKPPVTGPPSLFHVEGVRDEGLVVKGLDRSREGWLQMGCVRPGQMSVFPVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBU5</accession>
    <name>A0A2I2GBU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_356269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705637.1">
        <property type="nucleotide sequence ID" value="XM_024844139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBU5"/>
    <dbReference type="GeneID" id="36551839"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_356269"/>
    <dbReference type="OrthoDB" id="5298304at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000399">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="537" mass="59894" checksum="0406FDC2783B0F76" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBY5</accession>
    <name>A0A2I2GBY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidyl peptidase IV/CD26, N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_405419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705693.1">
        <property type="nucleotide sequence ID" value="XM_024846587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GBY5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GBY5"/>
    <dbReference type="GeneID" id="36554286"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_405419"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.60">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161:SF8">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014164258" evidence="1">
        <location>
            <begin position="19"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB50391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="666" mass="73636" checksum="6DEBF4392C768DBE" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GC28</accession>
    <name>A0A2I2GC28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_424794</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705717.1">
        <property type="nucleotide sequence ID" value="XM_024847590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GC28"/>
    <dbReference type="STRING" id="1392250.A0A2I2GC28"/>
    <dbReference type="GeneID" id="36555289"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424794"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB50415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="121" mass="13145" checksum="7ABC46F11C134CFB" modified="2018-02-28" version="1">MSAIGSLIFCNDCGNLLDESSGDPTKIVVCSVCGTRNKDILPKTIVSESKPSAFPSALRAKRSAVQTLTAEDKRTEALTQHTCAKCGRKEMYFTTVQLRSADEGSTVFLRCVCGYKETQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCN8</accession>
    <name>A0A2I2GCN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_435831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705950.1">
        <property type="nucleotide sequence ID" value="XM_024849030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCN8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCN8"/>
    <dbReference type="GeneID" id="36556729"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435831"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB50648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="308" mass="32717" checksum="4D77A47045286A3E" modified="2018-02-28" version="1">MVGRLAGKNALVTGAAGGIGLETTILMLREGASVLMTDISAPGLEKALAKVNQVVPTHDGKVEYRVVDVSKETEVEAAVAHLDAWGGLDVIFNNAGIMHAKDGDSEETPESIWNLTMDINVKGVWYGSKHAVKSLRRHGKKKGSVINTASMVALVGAATPQLAYTASKGAVLAMTRELAIVHAREGELHVVSVATIAKTSRFPLQLSVPCTSQVSSTASIDCCPSNRDSTPLLQDWLGDDKEKRFRREVHFPTGRFGEAIEQAHAVVFLASDESSFVNATDFVVDGGLTKAYVTPEGPATEAPKNLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GCP0</accession>
    <name>A0A2I2GCP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_381492</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705909.1">
        <property type="nucleotide sequence ID" value="XM_024845575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GCP0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GCP0"/>
    <dbReference type="GeneID" id="36553274"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_381492"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="452"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="983"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB50607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="996" mass="110729" checksum="CCB93D9B0CF5E709" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GD42</accession>
    <name>A0A2I2GD42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PhyH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_474303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706049.1">
        <property type="nucleotide sequence ID" value="XM_024853116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GD42"/>
    <dbReference type="STRING" id="1392250.A0A2I2GD42"/>
    <dbReference type="GeneID" id="36560814"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_474303"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB50747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="311" mass="34195" checksum="BD2E12DDFC51F0B1" modified="2018-02-28" version="1">MPNPPHQAQNPEVVELDASAPIEEIANILRRDGGIIIKNFLTPETIDQIHAEAQPYWGKLGVYQGKLFDEADPPLSGFAGKSPTFAHKAINHPTYREVAKALLKEESNVYRDGKRYNTVSYPVLAVSEAFNRGSPSTAQQLHRDDMAQHFDHIEGSGESSLLGLLVAGVDTTFENGATQVIVGSHKLPEARICGPSDRSLCSTCEMSKGDAVFILGSIWHGAGENKTNPPERRIIYSCHMGRGSMRTDENQYLGIDEEVVRSYEPEVQALLGWSVSQPYCGHVGMEDPIVRLGSREDPFGYGSFEGREVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDB0</accession>
    <name>A0A2I2GDB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_493030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706186.1">
        <property type="nucleotide sequence ID" value="XM_024854036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDB0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDB0"/>
    <dbReference type="GeneID" id="36561741"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_493030"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="59"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="471" mass="50771" checksum="B2AD8202EAA4F3BC" modified="2018-02-28" version="1">MHNNDTALPPYTMSESAKDTGGLGPDEISKVEASYENAIGTVTDLEKHKTVQGEAKFRRLGWKRMAVILLVEAIGLGTFSLPSAFATLGLVAGVICCVGLGLVVIYTGYLVGMVKIHYPEIHHYGDIGGLVLGRWGQELVGALYVLQLILMTASFCLTGTIAFNTLSDEGVCGLVFGIVSAILLFLLAIAPSFAEAAILGYIDLASVTITIAITIIGSGIEASNAPGGIAGRNWSAWPAPGTTFKDGMVAICNIMFAYSFSMFITPFMSEMHTPKDFMKSVWTLGIIEMVVYTLIGSLIFVFVGTDVQSPALLSLQGVLPKVAFGMALPLIFISGAIGNTVTARYVHLRIYENSIVRFINTPKGWITWIVTLAAITIIAWILAESIPFFDDLLALSSALLISGFVLYFPPVMWFKLIRDGKWYAPKNLVHAVSCVLVFFIGLLVLGGGTYASVQDIRHHYKIGAVRSPFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDG5</accession>
    <name>A0A2I2GDG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_463963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706214.1">
        <property type="nucleotide sequence ID" value="XM_024852208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDG5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDG5"/>
    <dbReference type="GeneID" id="36559906"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_463963"/>
    <dbReference type="OrthoDB" id="4425169at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB50912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23711" checksum="E5F22B5C1E15A500" modified="2018-02-28" version="1">MATTELIFPSIKTDPESLNEIERDWPVISKRLTHPNPGLLNAFRGFLLTEDGVDVRGAHREFLLFEWTQADDFHRFVKSEQFAEFAASIKHLVTGPPTLQLFETNVSPREAASAAVVEIIRLSVSDAANVETAVHTWEVISRLISDKRNTVNYGTSTNLENIVVVGIIGWESSEAQAQTTQDWKYVEAIDALRSLGAVNRLTVGIDPMELSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GDT8</accession>
    <name>A0A2I2GDT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator xlnR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylanase regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_446216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706366.1">
        <property type="nucleotide sequence ID" value="XM_024850775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GDT8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GDT8"/>
    <dbReference type="GeneID" id="36558474"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_446216"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB51064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="971" mass="104816" checksum="405C0182CF134178" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GE33</accession>
    <name>A0A2I2GE33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_320695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB51154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024706456.1">
        <property type="nucleotide sequence ID" value="XM_024843311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GE33"/>
    <dbReference type="STRING" id="1392250.A0A2I2GE33"/>
    <dbReference type="GeneID" id="36551011"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_320695"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB51154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="565" mass="61724" checksum="1BEAFFB1BEA57A50" modified="2018-02-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GF90</accession>
    <name>A0A2I2GF90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_80734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="PLB51546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1392250.A0A2I2GF90"/>
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    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7611"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="717"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="852"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB51546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126361" checksum="521C88EF1F436885" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GFK2</accession>
    <name>A0A2I2GFK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proline permease PrnB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_433540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024848519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GFK2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GFK2"/>
    <dbReference type="GeneID" id="36556218"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433540"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="49"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB51662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="548" mass="60009" checksum="99D276D3F25FE6A3" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GG09</accession>
    <name>A0A2I2GG09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_348821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707113.1">
        <property type="nucleotide sequence ID" value="XM_024843699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GG09"/>
    <dbReference type="STRING" id="1392250.A0A2I2GG09"/>
    <dbReference type="GeneID" id="36551399"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_348821"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000033">
        <property type="entry name" value="NADH kinase, variant 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB51811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="424" mass="46211" checksum="DBE0274F58D98653" modified="2018-02-28" version="1">MRPFTSSSHRYEIRDLESLSHRLIPKYQESQEADLLSLQWPIPLRNIFVVKKDCVPAVTESLIEFASHVTSTYPSTAIILEPKTAEEVHTSLPCPVYTAQSDKLPSSLHKKVDLTVTLGGDGTILHASSLFATCHNVPPVLSFSMGTLGFLSEWKFAEYKRAFREVYMSGAGVGDRAPILEDRAVATTAHDRLPSGTGPTGWSSVRGKSMGASRGARILMRNRLKVGLFTADGTPVQRDQNSVPMQGTLGRDGVYVMNEVLFHRGKEPHLAVVDLYVGGRFLTEAVADGIIISTPTGSTAYSLSSGGSIVHPLVPSILLTPICARSLSFRPLVLPSSTPITLRLSEKNRGRELEVSIDGVNMGQGMAVGMEARVWNEEMRHGENEWQGGVPCVMRRIVGSEAHDGWVGGLNGLLKFNYPFGEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGC7</accession>
    <name>A0A2I2GGC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative small nucleolar ribonucleo protein complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_401685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB51939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707241.1">
        <property type="nucleotide sequence ID" value="XM_024846383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGC7"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGC7"/>
    <dbReference type="GeneID" id="36554082"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_401685"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000219">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001680">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit (Pwp2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="751"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB51939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="900" mass="99105" checksum="F8345CC8C646A2DB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGP7</accession>
    <name>A0A2I2GGP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_377518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707355.1">
        <property type="nucleotide sequence ID" value="XM_024845404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGP7"/>
    <dbReference type="GeneID" id="36553104"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_377518"/>
    <dbReference type="OrthoDB" id="4526849at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="391" mass="43493" checksum="660B959AE267FC16" modified="2018-02-28" version="1">MDSIIRFIPTDAEQQHPLAREYICSAATVATPDPQSTQNSHGQSGSNWGIEEVNAVRAIPIVNVDPKRIVPEEYFPRSDNQHFAKLRRAIREADIDALKTYSTESFKGNPYKLLFEDLSELITTYTSEESIGNAHRRQTSTSSVETDLSTSSNEGKGEAVSVTALRNFIKATLPSMRGLAKLPIQGPVKPSLMCYSNANRFEWMLAGVKYVAINDGSVGVNFRGYFSGSNRFPMIPVAGLECKPRHAGGIKRGSGEPKNFILEIFAQEVAQLLGNMIAQRSELKNLGGRRSLLRDQHEDQEAFVLSMHGTLFYVSTAYFSPEYIQYIEGNELTELSVDNIFLWVKQSVHFDLKDIDQRVKALEFLWALLGYIASGEAKMNNVTAAITAMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGT2</accession>
    <name>A0A2I2GGT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_433949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707398.1">
        <property type="nucleotide sequence ID" value="XM_024848611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGT2"/>
    <dbReference type="GeneID" id="36556310"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_433949"/>
    <dbReference type="OrthoDB" id="4368092at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014131042" evidence="2">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB52096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="231" mass="23625" checksum="EDB57B2D66D66AAC" modified="2018-02-28" version="1">MKLATTLPLTLLSTISLLPSASAWKLTWHDEDGKGSVESGKGPHSCIEIQHAQGERYVWDNQGNENIGIYFYTSSDCSGTVAGWSTDKWAKDASRDLLSFEVKSEGAKTTGTMTTTGSHTSSDDSSASATVTTSTGRASNSTESGSSSAVGSKTNPEASATASSSAESSNTASAPSSTETEQSGSSTPSPTASATDGASTDESAASSLSKNSAVQLMAGLTFGLAAFEWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GGZ0</accession>
    <name>A0A2I2GGZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_462173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707441.1">
        <property type="nucleotide sequence ID" value="XM_024852085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GGZ0"/>
    <dbReference type="STRING" id="1392250.A0A2I2GGZ0"/>
    <dbReference type="GeneID" id="36559783"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_462173"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="100"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB52139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="576" mass="65415" checksum="46CA83934D75DBC0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GH38</accession>
    <name>A0A2I2GH38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mercuric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_377778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707495.1">
        <property type="nucleotide sequence ID" value="XM_024845418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GH38"/>
    <dbReference type="STRING" id="1392250.A0A2I2GH38"/>
    <dbReference type="GeneID" id="36553118"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_377778"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF5">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="421" mass="45822" checksum="28DA9E86CD75FB85" modified="2018-02-28" version="1">MLAELLLVCKALGLSFRQIYTYLSQALSPRLHRLTYRSVEHPRNVVVIGASFAGYHAARCLASSLPTGYRVVIVEKNTHLQVTWVLPRFSVVGGHEHKAFIPYGPYLSAVPKGSYEWVRDTAEQISVDEDGGGNVQLGSGTTIDFEYLVMATGASGSLPSRVGVTTKKEGMEMLSIEQDKLVAATDVVVLGGGPAGIELAGDAKSRYPEKNVTLVHSRKALLNDHFGPTLAKRALEELEKIGVSVKLGERVNVDGAVETGTVQLHSGETIPCSYLAKCIGQRPNSALIQALSPKSVSSSGHIRVRPTLQLADSTFDRIYAAGDVIELNCIRNARSAFEQARFVANNIVCSIRSKKQAEYRYGWWEGATKLTLGLTKAVAYMSDGTTEISMSMKSKEDIDSTMIWRFFGAKAFVDETNGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GHE8</accession>
    <name>A0A2I2GHE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_507130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024707603.1">
        <property type="nucleotide sequence ID" value="XM_024854451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GHE8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GHE8"/>
    <dbReference type="GeneID" id="36562157"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507130"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="106" mass="11787" checksum="BE6C6304B9600F7B" modified="2018-02-28" version="1">MPLDQITDQAQFDSAIKDHQSTIVIFSAVWSGISEATKRNYENVGSQYSGLYQAWIDIDESPDLAQKYSSNGIPTIIGFKNGAQVEKYIGPQVTEGEAKRFIEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GIW1</accession>
    <name>A0A2I2GIW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_434548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708127.1">
        <property type="nucleotide sequence ID" value="XM_024848739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GIW1"/>
    <dbReference type="GeneID" id="36556438"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434548"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB52825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="298" mass="34031" checksum="EB0A990A50A8CA4C" modified="2018-02-28" version="1">MIPTRVVNSSFLGGRLYSTSTRHLYRSDIAMPPIIHFVRHAQGTHNISLEHSHIPDPTITEHGIQQCHELERDFPRHSHVDLVVSSPFRRTLYTALKSFGPVFKANPKMEMLLHSDLQEVSDFPCDVGSERAALESEIRDEKVPADMSLISDGWQLKRGRHAPTREAITLRARDMRCWLKARPEKEIVVVTHGGLLHYLTEDWEENCRCTGTGWMNTEYRTYEFTDEVHDDLGGIDLQGRNVSLVETEESRTRRGKPRSPPTREEQRTLYKLGFEGWAAQGLCMNVAELEAKNKTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ29</accession>
    <name>A0A2I2GJ29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_507621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708191.1">
        <property type="nucleotide sequence ID" value="XM_024854501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ29"/>
    <dbReference type="GeneID" id="36562207"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_507621"/>
    <dbReference type="OrthoDB" id="4510061at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB52889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="180" mass="20273" checksum="180A0F48A6189107" modified="2018-02-28" version="1">MSDGLNQARALRLAEIINDYRTLLLHIPQQNVPVPADDYYEEGFVVIRESLAAAQNLMSSNYSPSMPANHGSTAETEKAELRRVILDGSARRFQAHRIYLRAAAAKRWAMHRANILHGQRPGPQHASQLKAVSNTFRQELAQVTNQHVVADLRAADMRAGHWLDEDPSLEVILNWIRAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJ59</accession>
    <name>A0A2I2GJ59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-tyrosine phosphatase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_444793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB52913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708215.1">
        <property type="nucleotide sequence ID" value="XM_024850658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJ59"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJ59"/>
    <dbReference type="GeneID" id="36558357"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_444793"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000106">
        <property type="entry name" value="Protein-tyrosine phosphatase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="164"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="377"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB52913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59442" checksum="D4F30FAB5836D22A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJG2</accession>
    <name>A0A2I2GJG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_434744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708323.1">
        <property type="nucleotide sequence ID" value="XM_024848785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJG2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GJG2"/>
    <dbReference type="GeneID" id="36556484"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_434744"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="443" mass="47973" checksum="C32737CDDFDCB217" modified="2018-02-28" version="1">MAASAIPSGGLIDPNKQAEYPIILGDKLAGKKDASRSKFVHIQYNHKSKSTNPLQRSVIKPSRVKDQYNLTITDRVQNSENVLNSSYKGSVDPEHAVSGPEEHNLILVFDAERKAFVLEPVATQLNFNLRSGPAKTSKQALELRQLRTLQEDDHGSGDDTSGVDDGPADESNPYDFRHFLPKDNADEDNKSVSDNATPEPYSAPSKGNTPLLMPTAKKPTASPNLKPSPNPKPLPKPQTNPLRQTKRPTAAAKPDTAAKPNPKPKPRVPEKAKQQDGPEVEAPKSSTPPDFGTGAISAHKAVPSPGSNIIVDGNLIIDMGSPPPSRPRFNINPAHFSSNNTPGMNVADDDEDDDEEIEDLRLPSPAGHEGRPAAPERLQPVSHAPVTEEEVEDDDALAAEMEAAFEESAREEEEARSQASQQGTLSHQYHVPSDDESEVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GJR0</accession>
    <name>A0A2I2GJR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_123530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708417.1">
        <property type="nucleotide sequence ID" value="XM_024842373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GJR0"/>
    <dbReference type="GeneID" id="36550068"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_123530"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB53115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="174" mass="19448" checksum="4F3B872D637CAAC7" modified="2018-02-28" version="1">MRKTRNSPGDFLCPELFFGTESRISNGSDGRLIAERSLSEGGPTGRKAAVGRASYAARLVVSSFFSRSAGWRTDPEELIQRTNQENRQETRTTRTEKRLRWQIPADLGPSELGFSSYLLLAAESACLRSFIFSDLRTRSYIICLISFDFSENPAFLAACLFGTLRDVSTRLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GK15</accession>
    <name>A0A2I2GK15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_379768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708517.1">
        <property type="nucleotide sequence ID" value="XM_024845500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GK15"/>
    <dbReference type="STRING" id="1392250.A0A2I2GK15"/>
    <dbReference type="GeneID" id="36553199"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_379768"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB53215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="304" mass="34122" checksum="3564DB4A3E447FA3" modified="2018-02-28" version="1">MPPRFLTQPSLKAFTGSSYIQSPLAALSLNPSKTSIRAGSAETRERRRHDPFLTAQSRRRKAANLSRQEVLTKEREGSLGDPVESRSTTFIQGLKDTQSGPQTPSGSDGKLNYFLDSEGLQNMLEYSKNLTSPIENLDRNTADPQLDKELAEKHLQDHKNAEDAINRIASVRNGNTQDRMRLNIQKCIEEFGRHNTDQKLPPKPTAPSQQSGTAALEKTPRVGPDTGSPEVQVAVLTAKILNLTRHLKTSNKDKHNKRNLRLLVHKRQKLLQYVRRKERGGPRWQHLIESLGLSDAAWKGEISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKG6</accession>
    <name>A0A2I2GKG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_435013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708672.1">
        <property type="nucleotide sequence ID" value="XM_024848851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKG6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKG6"/>
    <dbReference type="GeneID" id="36556550"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_435013"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB53370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="108" mass="11736" checksum="A2747C5A40F4B328" modified="2018-02-28" version="1">MAHGKVIEVDDPVIFKALTSSGPVVVDFFATWCGPCKAVAPVVGKLSETYPNVRFIQVDVDKVRSVAQELQVRAMPTFVLFKDGQALEKRVVGGNMKELEEGIKSISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GKH9</accession>
    <name>A0A2I2GKH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_380058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000002">
        <property type="protein sequence ID" value="PLB53384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708686.1">
        <property type="nucleotide sequence ID" value="XM_024845516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GKH9"/>
    <dbReference type="STRING" id="1392250.A0A2I2GKH9"/>
    <dbReference type="GeneID" id="36553215"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_380058"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB53384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="476" mass="54302" checksum="5286AAAB0C3F7A97" modified="2018-02-28" version="1">MTRTTSSRSRTGCIPCRRKHQKCDEQRPICSFCSFRGMQCQYPSGLKWMRQTEPMTSRHRPRAHRAGALSVLRSPAPFADTFRSTEEKAAWEYYTRLVSSNVPALDGPENPYRKLSITALSSPILLETIICIATEHMLNFGLGSVPVAAERQQRMLRSIRQSLLTIEPGQTHTDPTHEACLAAVVLQGIVVAQRPDGVVEPHIKCASFLMHALGYFNDISNHNPLARMTAQRFAMVDLMLAISRQRRPFSPVQFVLHQPDEARWDGTEPSFYEMTGCPQPLMCFLVRIAYLACDVDDRLDANLPIHDILNQAFTLETELRAWNTRYTGLVPDELPCPRSPLDILSECFYWTAHLLLARRVFRDPTRSPRVQYLAHTCFRLMDHLPTGCGPDSSLPQPFYLAAREAITVEDRNWVRGKHEAMTAYYREQQRHSAMELTERIWARGDELRGASTSGDNQSVEDRFVRDLDRGSSLFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GL93</accession>
    <name>A0A2I2GL93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">P170DRAFT_431466</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708942.1">
        <property type="nucleotide sequence ID" value="XM_024848042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GL93"/>
    <dbReference type="STRING" id="1392250.A0A2I2GL93"/>
    <dbReference type="GeneID" id="36555741"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431466"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000004">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000003">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="562"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="21">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PLB53640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="654" mass="73348" checksum="04500E00176FDA0A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLB6</accession>
    <name>A0A2I2GLB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_431486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708959.1">
        <property type="nucleotide sequence ID" value="XM_024848047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GLB6"/>
    <dbReference type="GeneID" id="36555746"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431486"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB53657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="56" mass="6284" checksum="EA293C4462DECFB3" modified="2018-02-28" version="1">MREILATLTARRRRPQVHWTITTLPLLIYDLYLTGLPLGAWGVIGSLILFAILPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GLE4</accession>
    <name>A0A2I2GLE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P170DRAFT_451720</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024708989.1">
        <property type="nucleotide sequence ID" value="XM_024851213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1392250.A0A2I2GLE4"/>
    <dbReference type="GeneID" id="36558912"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_451720"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="17">
        <location>
            <begin position="49"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="16">
        <location>
            <begin position="359"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="19">
        <location>
            <begin position="588"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="18">
        <location>
            <begin position="775"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="20">
        <location>
            <begin position="1027"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="664"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1232"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1489"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1489"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PLB53687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1805" mass="200092" checksum="EB8E1942652E8EA5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GM66</accession>
    <name>A0A2I2GM66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_396969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB53966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709268.1">
        <property type="nucleotide sequence ID" value="XM_024846147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GM66"/>
    <dbReference type="STRING" id="1392250.A0A2I2GM66"/>
    <dbReference type="GeneID" id="36553846"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_396969"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="568"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB53966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1026" mass="118671" checksum="081F76EDE177AE84" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GMJ8</accession>
    <name>A0A2I2GMJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_469577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709414.1">
        <property type="nucleotide sequence ID" value="XM_024852650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GMJ8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GMJ8"/>
    <dbReference type="GeneID" id="36560348"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469577"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="39"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB54112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="383" mass="42859" checksum="1037C6D976B61EB2" modified="2018-02-28" version="1">MRVNTVSKAPLGLLALYATSASAFWRMMCPSRLVQQRADPIMSPGEVAGHVHTISGGNGFKFDMNYDDARNSDCSSCPIKQDLSNYWTPKLYYHAENGSFISVPQIGDQWDNTGGMNVYYFQRGGPNQDEIKAFPKDFRMVAGDPFKRSFDDDKPSQAVSFVCLDYNAEPKPETNEFPNENCPDGLRVQVFFPSCWDGENLDSDDHKSHVAYPEPFNDGSCPESHPVHLVSIFYEVLWNTGVFADEWYGDSQPFVLANGDPTGYGFHGDFINGWDIDVLQTAIDKCLNLSGNLEDCVDENGTPVFEFFSDEECQQCSLPNLVDEDIDGIFENLPGCNPLTGGPDRAEPEECDKPAILEAPAEKRKRQQHEHLARHRHGAHHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN02</accession>
    <name>A0A2I2GN02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_431889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709564.1">
        <property type="nucleotide sequence ID" value="XM_024848140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN02"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN02"/>
    <dbReference type="GeneID" id="36555839"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431889"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014112861" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="23"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="442"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="185"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB54262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="569" mass="63039" checksum="CE4D6DE651163E02" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN64</accession>
    <name>A0A2I2GN64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P170DRAFT_431962</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709633.1">
        <property type="nucleotide sequence ID" value="XM_024848158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN64"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN64"/>
    <dbReference type="GeneID" id="36555857"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_431962"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="15" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="8 19" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PLB54331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="309" mass="34092" checksum="FC3BDCB7C76121E7" modified="2018-02-28" version="1">MAAAQVISNSGHDDMIHDAGLDYYGRRLATCSSDKTIKIFEIEGETHRLIETLKGHEGAVWCVAWAHPKFGTILASSSYDGKVLIWREQHQNSTSPVAGSSWTKVFDFSLHTASVNMVSWAPHESGCLLACASSDGHVSVLEFRDNSWTHQIFHAHGMGVNSISWAPATSPGSLISSNPGPGQQRRFVTGGSDNLLKIWDYSPETKSYNLTQTLEGHSDWVRDVAWSPSILSKSYIASASQDKTVRIWTSDASNPGQWTSQQLEFDTVLWRVSWSPSGNILAVGGGDNKVSLWKENLKGQWEKVKDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GN83</accession>
    <name>A0A2I2GN83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SWI-SNF chromatin remodeling complex, Snf5 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_397658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709636.1">
        <property type="nucleotide sequence ID" value="XM_024846189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GN83"/>
    <dbReference type="STRING" id="1392250.A0A2I2GN83"/>
    <dbReference type="GeneID" id="36553888"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_397658"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB54334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="566" mass="62726" checksum="DB4BCE16777FEF31" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GNH6</accession>
    <name>A0A2I2GNH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P170DRAFT_469900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB54434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024709736.1">
        <property type="nucleotide sequence ID" value="XM_024852685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GNH6"/>
    <dbReference type="STRING" id="1392250.A0A2I2GNH6"/>
    <dbReference type="GeneID" id="36560383"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_469900"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PLB54434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="78" mass="8940" checksum="EB72129F9F3BD611" modified="2018-02-28" version="1">MNAATALRARMATSFVARRGFSTTRAQLGSPYHYAEGPRSNIPFNPNTKYFFFRYWAFMITGFGAPFGIAVWQTYKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GQN2</accession>
    <name>A0A2I2GQN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_461111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710490.1">
        <property type="nucleotide sequence ID" value="XM_024852000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GQN2"/>
    <dbReference type="STRING" id="1392250.A0A2I2GQN2"/>
    <dbReference type="GeneID" id="36559698"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_461111"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05198">
        <property type="entry name" value="formate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="30"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="167"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB55188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36958" checksum="89A8AFE1268D8F75" modified="2018-02-28" version="1">MSVDGQHHNIVAIEAIHCPIPAPALPLPQSYTLIQHQWTSQSDLAPRIKDATIIITTTIALTAKELSPEVTPHLRLVVVMATGTDCVDKDAARARGIPVCNCPGTNVESVSEHAIGLYFATRRKIVQLHCATAAIPADPERDTDWKTTGSLHRRLRSKDGHAPVLCGRETLGVIGYGALGQRIAKVGAALGMKVLIAERKGEVERPRAGRTPFDQVLRQSTVVILCLPRTPETEGLISREELEGMHPQALLINVARGGIVDESALLEALRQGWISGAATDVFAREPAGRGDSPLLGVEAEGLNLVLTPHLAWLSEDTLVNLQDAVKWTIERWCAGETVNDVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GR16</accession>
    <name>A0A2I2GR16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ragulator complex protein LAMTOR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P170DRAFT_505918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAMTOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710615.1">
        <property type="nucleotide sequence ID" value="XM_024854331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GR16"/>
    <dbReference type="GeneID" id="36562037"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_505918"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401:SF2">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PLB55313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="169" mass="18316" checksum="0472D166BAE4A34B" modified="2018-02-28" version="1">MGICASCLGLSRRDSQDSESSRLLEDDIYQSGYGYGALNHANQVAQPDTGYIKREREALEAICQRTSDNVIDIWSLQPQPHLQPQATLHGPVSPSTSKSGATDDVPVRITTSPPSERPESADKDSATKPGAVPKHWGEVVINPRKGKQARSGSNYETNARDVFGVLKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GRG9</accession>
    <name>A0A2I2GRG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_506072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000001">
        <property type="protein sequence ID" value="PLB55480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024710782.1">
        <property type="nucleotide sequence ID" value="XM_024854354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GRG9"/>
    <dbReference type="GeneID" id="36562060"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_506072"/>
    <dbReference type="OrthoDB" id="5360255at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB55480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="426" mass="46657" checksum="5A700659FE028F54" modified="2018-02-28" version="1">MYQRSHQSEQHTKLASLSLAKFSHTTTSASHRGPLHWNHIIGNGDIVGVFERFTVSGNVLLKVFQDDQIIEQISITDLAQIAASEAQSSNPGSSKPTFAVVVKLPCLAIKYSTGNTHIRRFQIKFSLDRDYYTVLAILSDIKCPFSEPNIDPMPLTRRPSTAQWQMASSSSAMGGRVGGNLAPEQYASHGAFIQPHESTLGVSGTTSSITAAQTSLPSSSSTMPNVPAESWPNDRNRSGPRDTNISQDIAPRDPIPGQSNNALIRRPSTATTCYDAKSLETILPPKRQLPFLNPGPQEANKRPTTSSGHIFRKPEHTNLSGLSKPTNTSITPSTGSGSLPFPPPNNEKHHQSMNTEPVQNKPSQQESLDIQNPHLRSENLSAYVSSSTEERTKSLANWICQQIEDEKFVQLVQDMDGTWERLALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FQ66</accession>
    <name>A0A2I2FQ66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_417834</name>
        <name evidence="5" type="ORF">P170DRAFT_514712</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000030">
        <property type="protein sequence ID" value="PLB42774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698921.1">
        <property type="nucleotide sequence ID" value="XM_024847182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FQ66"/>
    <dbReference type="STRING" id="1392250.A0A2I2FQ66"/>
    <dbReference type="GeneID" id="36554881"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_417834"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_514712"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001196">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_1G12380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB42774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB43619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="375" mass="41256" checksum="9ADB7C5B8FBA5145" modified="2018-02-28" version="1">MSRSDNPDHFFQTTAALDEQQRKDAKSRNTNGSPIKLQSKILAVQADPVNPDAVFVAQSGGTVRKVILETGDTAAIYKGPSAPITSLCFSPDGRSLFAGCWDKLIWSWDVASREPKLKYDGHTDFVRSVASARLNGQDVLISGGADAQILVFDIATGKRISVLKGHAKGIQDLVVDPVSLESDGQEFIVFSAGSDREIRQFDIATGSRDLTGTDALLAHDTNVYKLFFDRDGDLWTASADKTTKCLVREDGWKPNLTLTHPDFVRDVVVYEQGGWIVTACRDEEVRVWNRSTGKLHHTFSGHFEEVSGLALVGSTVVSVSIDATIRQWSLKPQDLQEAVERAKKTTPEEDEQPQNSGSMLTEEEERELAELMGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRC8</accession>
    <name>A0A2I2FRC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle pole body-associated protein cut12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_73762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698484.1">
        <property type="nucleotide sequence ID" value="XM_024855357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRC8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRC8"/>
    <dbReference type="GeneID" id="36563063"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_73762"/>
    <dbReference type="OrthoDB" id="5383703at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021589">
        <property type="entry name" value="Cut12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11500">
        <property type="entry name" value="Cut12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle pole body-associated protein cut12" evidence="3">
        <location>
            <begin position="161"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB43182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="736" mass="82702" checksum="BFC52C32C60262A9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FRC9</accession>
    <name>A0A2I2FRC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_441650</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Extracellular serine carboxypeptidase that contributes to pathogenicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000011">
        <property type="protein sequence ID" value="PLB43190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024698492.1">
        <property type="nucleotide sequence ID" value="XM_024850366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FRC9"/>
    <dbReference type="STRING" id="1392250.A0A2I2FRC9"/>
    <dbReference type="GeneID" id="36558065"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_441650"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB43190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="506" mass="56096" checksum="5AD9D6B04A6E74D0" modified="2018-02-28" version="1">MNGGPGSSSMIGLMQENGPCIVNADSNSTELNPWSWNNYVNMLYIDQPNQVGFSYDVPTNGTLNRLTSEMDVSPFPDGEVPQQNNTFYVGTFPSLNQSATANTTQNAARALWHFAQTWFTEFPHYKPHDDRVSIWTESYGGRYGPSFTSFFQEQNEKVAKRSVSNDLDAHYIHLDTLGIINGCVDLLVQAPGYPEMAFNNTYGIEAINRTVFERAMDAWSKPGGCKDLIVECRHLAAEGDPKMYGNNQTVNAACKDANDRCLNQVEGPYQEFSGRGYYDIAHLNPDPFPPASFLGYLSQHWVQASLGVPVNFTESIDSVYNGFDATGDYPRSDVRGYLEDIAYVLDSGIKVALVYGDRDYACPWNGGEQVSLQVDYTDAEQFRSAGYAPLQTNATYVGGRVRQHGNFSFTRVFQAGHEVPAYQPQTAYEIFHRALFNRDIATGKVSTAANHNYTSEGPSSTWNITNEVPPNPAPTCYILSLSTCTEEQIERVSNGTAVIKDYTVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTL1</accession>
    <name>A0A2I2FTL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P170DRAFT_418438</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB43956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699258.1">
        <property type="nucleotide sequence ID" value="XM_024847222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTL1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTL1"/>
    <dbReference type="GeneID" id="36554921"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_418438"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001557">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="745"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="422"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PLB43956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1059" mass="114196" checksum="CE588C6D20981AA7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTP9</accession>
    <name>A0A2I2FTP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_394179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699311.1">
        <property type="nucleotide sequence ID" value="XM_024846050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTP9"/>
    <dbReference type="GeneID" id="36553749"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_394179"/>
    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="251" mass="27490" checksum="8E232BB15160A4DC" modified="2018-02-28" version="1">MDAAPRMEHVRRVSTQRLPPPALFQGPPSHNASNLSLAPPVPAVSSPGTSQPPPLQRNRSSRQPGALEPPGSLSPFVSRRPSKGEADRSDAIWQEMQNALSEVELSAVTSEYVFGEKHSEALEDLRTKQLKLAQAWARSEADDEGAENKGKPPSGPKGSRNPATTGEPVVPDDASHRNLDEETEKDLILARERREANDRYFDRVNSGVLDVVAKLEEVAQAMRVVERESRDIWSDNETDSVTMSTQSTHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FTW1</accession>
    <name>A0A2I2FTW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">P170DRAFT_468780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="MSFO01000010">
        <property type="protein sequence ID" value="PLB44080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FTW1"/>
    <dbReference type="STRING" id="1392250.A0A2I2FTW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468780"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="246" mass="27004" checksum="1B521075137D9AAA" modified="2018-02-28" version="1">MEHSNNHSPTPDGVDVDLEVSESLVPMRDLKAAEQNTVSLDGLLAEPLILKEDLKEGCGGQLWPAGMVLAKYLLRRHRLDLSNKTIIELGAGGGLVGLAVARGCNVGEPPIYITDQAPMLPLMETNIKINNLASTVVAGVLNWGEALPDSIPRHPAVVLAADCVYFEPAFPLLVSTLSDLLGPESICYFCFKRRRRADLRFMKMARKVFDVEIITDDPDAEAYGRENISIFSIRPKHGEKRASRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU45</accession>
    <name>A0A2I2FU45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_416616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699472.1">
        <property type="nucleotide sequence ID" value="XM_024847132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU45"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU45"/>
    <dbReference type="GeneID" id="36554831"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_416616"/>
    <dbReference type="OrthoDB" id="3029470at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="491" mass="56176" checksum="E914168240C505AE" modified="2018-02-28" version="1">MASSEHNLSSSTPARALTNGWPRITESSPVRDLGPGTMDYERCAALHNELLTRAVKGHGGEMPSKPLTWWEAREPSEEVANSLHPCLIEFLKRAWDEDVLPPYFRLFAFLGGLKSPNNLRDGDVTWHEEEDEEGRLVKLYESSHYRVSDDEGIFFDQTTLKATFIEDINDTRFITRHEWSWMPLEVILDSYLQMADEEKAQAVSKDRAKLLKMDFLHGLMEPWIIHQYTKTDLERATTAFKRLVRVIESRIPDRDDHTTVMNLPWHDPATFEDQCVLPPSSFAHEFLRSISDCSVRFRYIAPGIRFPTVAEFQDQPFTDFVASPHNHLGQYPGNCPLRILQIDDAEYPQPVAHGKHLGINNIAAGFYIPHVVVPCPLFWSNGCRLLLPYAIGALGWARLSNGQPFGLSDCDYMEEYPEPRDDHGDLYQAGTTNGITNNHRVQIEKVLNNWADRVERGDWEVDGDGVAGGIDKFREADTEAHWQKYWIPPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FU51</accession>
    <name>A0A2I2FU51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_440504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699446.1">
        <property type="nucleotide sequence ID" value="XM_024850094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FU51"/>
    <dbReference type="STRING" id="1392250.A0A2I2FU51"/>
    <dbReference type="GeneID" id="36557793"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_440504"/>
    <dbReference type="OrthoDB" id="5131368at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151">
        <property type="entry name" value="BLR2777 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151:SF3">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="271" mass="31069" checksum="A27AA6A67F188D11" modified="2018-02-28" version="1">MSSSENSEKSSPILDNPQHIQKVVQEGLLLGGGAAAILLQVAMPGVGKGVDNHSNFSYRPLDRLRTTMTFVYCMAFGTNDEKRAVVDMVHRAHAPVKGADYDANDTRLQVWVAATLYAVGTDMYEQVFGAMDECAAERLYREYAILAVSLRVRPEEWPESRAKFWEYWDEQVESMEVTENAKNVANDLLFNYKLPLHLRVLMPWIRLVTAELLPPRIREAYGLKTTKVRRGAYRVTVGFARATYPCLPMFVRTYPKRYYMKDMRRRLQKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FUM4</accession>
    <name>A0A2I2FUM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_468042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699642.1">
        <property type="nucleotide sequence ID" value="XM_024852524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FUM4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FUM4"/>
    <dbReference type="GeneID" id="36560222"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_468042"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="68606" checksum="CD9B520671A76A74" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FV99</accession>
    <name>A0A2I2FV99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_287522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000009">
        <property type="protein sequence ID" value="PLB44496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024699798.1">
        <property type="nucleotide sequence ID" value="XM_024843217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FV99"/>
    <dbReference type="GeneID" id="36550916"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_287522"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB44496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="193" mass="21509" checksum="6B726C3E712CF156" modified="2018-02-28" version="1">MTESHPCWDWMIVLTSTHHYARDRLFFKDYVPVGIRSPASPFGEEDLDIAGMGTVELLVHTGPESTSTTRTLVLKNVLHIPNALCNGFNGLQYSQVNGGGGLTFGSLTRQGTDRDGSPLWYAKPFHGFSRLVIAGNPEGKSYLEDGLISLSIFVDETRLPQIVRPRARDRAEETSSNFRCTKGTVFPHMYLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWI6</accession>
    <name>A0A2I2FWI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="14">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P170DRAFT_415900</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="14"/>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700302.1">
        <property type="nucleotide sequence ID" value="XM_024847090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWI6"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWI6"/>
    <dbReference type="GeneID" id="36554789"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_415900"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013987970" description="Extracellular metalloproteinase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="16">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PLB45000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="633" mass="68296" checksum="E5795BFAC05DC6FC" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FWP4</accession>
    <name>A0A2I2FWP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_513122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000008">
        <property type="protein sequence ID" value="PLB45050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700352.1">
        <property type="nucleotide sequence ID" value="XM_024855068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FWP4"/>
    <dbReference type="STRING" id="1392250.A0A2I2FWP4"/>
    <dbReference type="GeneID" id="36562774"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_513122"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB45050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="217" mass="23870" checksum="CA36A4CFF9BD7F79" modified="2018-02-28" version="1">MGSTQVEFKNPATATLLEAVKARRTVYALKGESPISDEAIQNIVETSVLHVPSSFNTQTSRVVLLLKEEHKKVWDITLAALEGLVAAGAVPREAFESSTKPKIESFRAAYGTVLFFVDYESLAPIKEKFAIYADKFDPFALESNAMSQYLVWTALESEGLGANLQHYSPLIDEGIQKQWNLPGSWKLDAQLVFGTPAAAPGEKAFAPLEDRFKVFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXP8</accession>
    <name>A0A2I2FXP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_243185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700710.1">
        <property type="nucleotide sequence ID" value="XM_024842963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXP8"/>
    <dbReference type="GeneID" id="36550662"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_243185"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="111" mass="12348" checksum="37FA52A038387897" modified="2018-02-28" version="1">MLRYCIFHSILPCSSSPCFPLSLSFFFLSTPYLPIIFLFLFLFHDLLIFTLMAAGVWMTLMVHVSATRPLRELEIPREGGQGAESKRCNGGLTRVGGVRCGCSETLPKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FXR8</accession>
    <name>A0A2I2FXR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_439198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700737.1">
        <property type="nucleotide sequence ID" value="XM_024849785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FXR8"/>
    <dbReference type="STRING" id="1392250.A0A2I2FXR8"/>
    <dbReference type="GeneID" id="36557484"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_439198"/>
    <dbReference type="OrthoDB" id="5405654at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="206" mass="23160" checksum="8C7FAF807BFB74A7" modified="2018-02-28" version="1">MAPKRPSLHPLTTPKTMTFPSELRERTYTTTLEPNEGCKKEDEDTEFSMTPPPAYTEFLNTFSPIFASPDTSRANFSKYMLDKPRPSPTSAPSSSTSTTFHGGNPSPRTLPPPHLSVPNRTPDHVRRMRLPPPYGYTPASESPRSAHPLRSPYTPSEMRTHHFDSPVSDHAGYFSIRHVVTTTITYKRTPQLEAPPQGKRRRNGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FY41</accession>
    <name>A0A2I2FY41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_246360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB45549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024700851.1">
        <property type="nucleotide sequence ID" value="XM_024842989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FY41"/>
    <dbReference type="GeneID" id="36550688"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_246360"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB45549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="97" mass="10860" checksum="32F8375B7F090DA6" modified="2018-02-28" version="1">MKLWLENRQTDGPKVTDSILESGWTSGLSPHLVLLFVIVAFLFLFLFFCLAPGSGGGWGFDQTFQIPCLGGHRRVWLGGSSRREREWGFSLPCDGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZG0</accession>
    <name>A0A2I2FZG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-sialoglyco protein endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_414810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701320.1">
        <property type="nucleotide sequence ID" value="XM_024847032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZG0"/>
    <dbReference type="STRING" id="1392250.A0A2I2FZG0"/>
    <dbReference type="GeneID" id="36554731"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_414810"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000252">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000377">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="3">
        <location>
            <begin position="128"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB46018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="469" mass="51150" checksum="C33AABD048DEA061" modified="2018-02-28" version="1">MLHSRLPAAVCRRKICAVPKPKWSLPSRYRGLLTLAIESSCDDTSVAIVEKKTGPSGAIAKTHFLENVTADTTSYRGVHPVVALESHQENMAKLVNKALSHLPTPSEDTNGGHGLLHLSNDPTPRRKPDFVSATRGPGMRSNLFVGLDTGKALSVAWQVPFVGVHHMQAHLLTPRLVSCLERAQDEASETVSPKPTTPEFPFLSILVSGGHTILVKSSSLTDHEIMASSSDVAIGESLDKAARDIIPEPVLQSAKTTMYGKLLEQFAFPNGSIDYADYRPPMTRGEELAKRETPWGWSLTTPFAKTRQLEFSFASIATSITRILSAKDKAGKTMGDEERVVMARESMRVCFEHLASRTVIALEALRDQGTGDEVKTLVVSGGVAANRFLMTVLRSFLDVRGFGHVSIIAPPPSLCTDNAAMIGWAGIEMFEAGWRSDLSCRAWRKWSLDPRAEDGGILGPADWVRLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2FZU7</accession>
    <name>A0A2I2FZU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_365783</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000007">
        <property type="protein sequence ID" value="PLB46141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701443.1">
        <property type="nucleotide sequence ID" value="XM_024844725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2FZU7"/>
    <dbReference type="GeneID" id="36552425"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_365783"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="32"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB46141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="468" mass="50854" checksum="97CF77625D20683B" modified="2018-02-28" version="1">MLTTEQAPSQSTLHEISPAASKAVVRKQDLRILPLSAFIYFLCYLDRSNIGNAKIMNSSTHNDLMTETGMSNYQYTIGLMIFLVAYGVFEAPSNILLKKLRPSKWIAFLMVSWGALTISLGASKNPATVIALRFLLGIFEAGLFPGLVYYLTFWYKTDERSMRVALILASATLAGAFGGAIAYGVGHMNQVSGVSGWRWLFYLEGIPSVVSGFAVWFILPDYPETSGWLSAEEKAVAAERLRIEGSKGTHKSITWEDAKSTLTDWRLYGHYLIYLAISCPFSSLSLFSPSIIKGLGYEDLNAQLMTVPPYAVAYVIQILTSYSADHFNARALHSAACSLTGGIGFLASALLPAHSYSARYACLFIANMGAFSCIPPLLGWLSSNIAGTSAVGLAIALNIGLGGSPGQIIGVWIYKAEEAERGYPTGHGTNAAFCFLAAGMCLALRVYYGVRNRRILKEGGEGGRLFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G106</accession>
    <name>A0A2I2G106_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P170DRAFT_511292</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024701850.1">
        <property type="nucleotide sequence ID" value="XM_024854873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G106"/>
    <dbReference type="STRING" id="1392250.A0A2I2G106"/>
    <dbReference type="GeneID" id="36562579"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_511292"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000010">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="15"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="404"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="16">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="404"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
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        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <begin position="536"/>
            <end position="540"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <begin position="581"/>
            <end position="583"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
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        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="673"/>
            <end position="676"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
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        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PLB46548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="785" mass="86202" checksum="DD6D145DDF3313DB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G126</accession>
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        <submittedName>
            <fullName evidence="2">Endo-1,3-1,4-beta-D-glucanase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">P170DRAFT_511291</name>
    </gene>
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        <lineage>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB46546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="210" mass="23150" checksum="4F7FE3FD3D70519D" modified="2018-02-28" version="1">MTSDCCKSGFKWHATPTGTESSFAGTKTYVTGTSKSIAILYVHDIFGWTFPNARLLADYYAENANATVYVPDLYPTILNFATALRSQYPKVAAIGFCYGGWAVFRLGANGLGLVDCIATAHPSLLEDREIEALGVPTQILAPERDFAFTEELKGVCNRVIPANGVPYEYVYFPGLEHGFATRGDREDEVQRRGLERAARAAVGWFNEWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1G3</accession>
    <name>A0A2I2G1G3_9EURO</name>
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        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_438408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024849596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1G3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1G3"/>
    <dbReference type="GeneID" id="36557295"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438408"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="229" mass="24862" checksum="0B51AC1DEEEF81DE" modified="2018-02-28" version="1">MNGGFAEYCAYPAGRVFKIKNLSDVDATLLEPASCAAHGLDKIAPKMGSSVLLFGAGPTGLILAQLLRLNGGCRVVVCAPEGLKLDLAKSLDAGDEYIALSRKDPSAQFEQLKKDNPYGFDIVVEATGSVKILEDSINYVRRGGKLVVYGVYSNKDRVSWPPSKIFGDEINILGSFSETYKFPAAIDYLDSGKVKVKGIVNKVYNIHQWEECLEAMKNKTAIKAAITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1I0</accession>
    <name>A0A2I2G1I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_477606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702037.1">
        <property type="nucleotide sequence ID" value="XM_024853488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1I0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1I0"/>
    <dbReference type="GeneID" id="36561186"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_477606"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB46735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32667" checksum="E9D7B1055ADE55BA" modified="2018-02-28" version="1">MAHAVTEVALLTFLPDADIESSLSTVEAISSRQEGIGERRWGRVGDDETTVQFLANWADISYHEQYIKILTPILAAPPVVFHVHLDQNVLHRVLDAPIVEVVTFYGTSEETQSIPGRVLGSSSAQGSHSTVVHGPVVEQLAKPGDNATTRAYFAMAGWDSRNNPGLLGTMEPVIVRNELGSATIQVRALLEDCRGLSDAGEVVIWCILSAGLDLFIFSLASAVLPGGNEVDLQQYMASTLRSLRTLNTSYQLHKLPRQLRLHHTIINAFLFAIRSRLQHGAAKVSRAEAEPLFANAVNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G1L3</accession>
    <name>A0A2I2G1L3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dual specificity phosphatase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_448532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702060.1">
        <property type="nucleotide sequence ID" value="XM_024850970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G1L3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G1L3"/>
    <dbReference type="GeneID" id="36558669"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_448532"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000273">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="640"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB46758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="735" mass="81611" checksum="4700C75C24B761B6" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2A5</accession>
    <name>A0A2I2G2A5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_412451</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB46995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702297.1">
        <property type="nucleotide sequence ID" value="XM_024846932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2A5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2A5"/>
    <dbReference type="GeneID" id="36554631"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_412451"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="51"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB46995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="386" mass="42157" checksum="01A05AB8D369AB25" modified="2018-02-28" version="1">MFSLRTAQSAQSFLRRAAVTTSLARSSIPVRSFASVQSDIFKPTKYGGKYTVTLIPGDGIGAEVAESVKTIFKADNVPIEWEQVDVSGVDTGNKHSEELFKESIASLRRNKLGLKGILHTPVERSGHQSFNVALRQELDIFASIVLIKNIPGYQTRHENVDLCIIRENTEGEYSGLEHQSVQGVVESLKIITRAKSERIAKFAFGFALANNRKKVTCIHKANIMKLADGLFRSTFHKVAENYPTLEVNDMIVDNASMQAVSRPQQFDVMVMPNLYGGILSNVGAALVGGPGLVPGCNMGRDVAVFEPGCRHVGLDIKGKDQANPSAMILSGSMLLRHLGLDDHANRISKAVYDVIGEGKTRTRDMGGQATTHEFTRAVLDKMETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2P9</accession>
    <name>A0A2I2G2P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_438860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702450.1">
        <property type="nucleotide sequence ID" value="XM_024849701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2P9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2P9"/>
    <dbReference type="GeneID" id="36557400"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_438860"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="45"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB47148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="562" mass="62231" checksum="47E36F619D2393F9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2V9</accession>
    <name>A0A2I2G2V9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein ras-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_236410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702511.1">
        <property type="nucleotide sequence ID" value="XM_024842922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2V9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G2V9"/>
    <dbReference type="GeneID" id="36550621"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_236410"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="213" mass="23978" checksum="D7F4816A0177A1E5" modified="2018-02-28" version="1">MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFEEIMTFQQQILRVKDKDYFPIIVVGNKCDLEKERAVTEQEGEALARQFGCKFIETSAKSRINVENAFYDLVREIRRYNKEMSSYPSGSGAFGSRAPEGKMDVSEPGDNAGCCGKCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G2X4</accession>
    <name>A0A2I2G2X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_236903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702528.1">
        <property type="nucleotide sequence ID" value="XM_024842926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G2X4"/>
    <dbReference type="GeneID" id="36550625"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_236903"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="105" mass="11593" checksum="0BA36392CA5D475A" modified="2018-02-28" version="1">MGHATGGCPCMAEAGTSTQLLSGRDFGCRICILASGTCLLSHNVGRRCWALWRGRGRGNWSQRDAAADTKMRILISDTERSVMHVISRVEGSVKRRRLYFLGTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G388</accession>
    <name>A0A2I2G388_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_466626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702646.1">
        <property type="nucleotide sequence ID" value="XM_024852431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G388"/>
    <dbReference type="STRING" id="1392250.A0A2I2G388"/>
    <dbReference type="GeneID" id="36560129"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_466626"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014186687" evidence="5">
        <location>
            <begin position="23"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="470" mass="53972" checksum="A35E91ECF0EDFF13" modified="2018-02-28" version="1">MLALYLLSLLAVLSLFFRTLRVHRTAVPGPWYTKLTSLVLKYHEFTRNRRLWIHNLHKAYGTVVRLAPNEVSFSNLDGVKEIYQSGGSGYDKTEFYGLFRQYNHRTMFSTLNKHDHSQRRRLFADRYAMTNIVSSPVMDGIRQRAAQVVAKCRASIGGHLDIYGTLHCYALDCASHFLFNPGGTQTLNEKDVVLMEELSHHDSLKQRVIQHYWPWLNTILTFYQPRKMLLSQEFVLDRTLNSQPHDSSLLSKLQSKSADLERVQMAAECMDHMAAGIETTGDSLCFLMHELSLPRSRRIQEKLRHEARQNLDKKTDELPYLDAVIKEGLRLFAPIPMSLPRYVPLNGRTIAGYTLPAGEIVSCQAYSVHRLNEGVFPHAEEYWPERWLEQEGELERNRLFFAFAAGGRGCIGRNLAVVEMKTLLRELYSKFTTTVSEEMKGDMSIDDQIIASRPKDQTCLLSFSEATAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3D5</accession>
    <name>A0A2I2G3D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_413282</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702686.1">
        <property type="nucleotide sequence ID" value="XM_024846967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3D5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3D5"/>
    <dbReference type="GeneID" id="36554666"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_413282"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014140694" description="Cutinase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="77"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="287"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PLB47384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="326" mass="31423" checksum="76546471AD67B9E6" modified="2018-02-28" version="1">MKAAIALSLITAALAAPTKTVESRQLPGLGGSSSSSSGGLSGLSSLIPSGLAGGGSSGSSSGGLPDLSKLLGGGSSSGSSSGGLPDLSSLLGGGSSSSDSSDSSDSSSSSGSDSSSDSSSGSDSSSSSSGGLPDIGSLLGGGSGGSMTENDVAQNKGCKELTFIFARGTTEMGNMGSVVGPPVAKNLNSLTGNQCAVQGVDYPADAAGNAMMGASGGPKMAEMVQKALKQCPKTKVVLGGYSQGSMVVHNAASKLSEGQIAAAVLFGDPFKMQAVGKLDKSKTKEFCASGDPVCENGFNVMAHLSYGGQAKEAAQFLVQAAGVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3E0</accession>
    <name>A0A2I2G3E0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P170DRAFT_478242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702694.1">
        <property type="nucleotide sequence ID" value="XM_024853542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3E0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3E0"/>
    <dbReference type="GeneID" id="36561240"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_478242"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04433">
        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PLB47392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="569" mass="63483" checksum="C2CBEBAA19790E4D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3J4</accession>
    <name>A0A2I2G3J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_389027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000006">
        <property type="protein sequence ID" value="PLB47452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702754.1">
        <property type="nucleotide sequence ID" value="XM_024845857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3J4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3J4"/>
    <dbReference type="GeneID" id="36553556"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_389027"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB47452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="488" mass="53059" checksum="39D59C50B7327391" modified="2018-02-28" version="1">MRHAHEPFVQPGYAELNPEYDQGVNAKPVWSLAKPLPRVVRPGMVPTMDELRQAHRQAPWPAARSHRAGLDVDPDELTKGRILPTSNPLKIAAQVEDARLQREANLANKILRGDTASLSSSSRRFRRASTWALPPERLATVPEGDTPPEEGVDRPSEGLQETDPLLVDEPDELDFTTLEKSGDLQPLIEELVDEEVHNHHTTWSVVRTHYREALAEGLSVYVQLTLGFGADLAVTLANAGNPNTTAWAWGFATMLAIYISGGVSGAHLNPVITLVLWFYRGFPTRKIPGYFAAQFLGALFAAMTAYSLYYPSIQLYLDTSADGGILNSFVTGPRAPWIGAPTAFFTEFVGTAFLTIAVLALGDDQNAPPGAGMNALILGLVITLLSITFADQTGAAFNPSRDLGPRLVLLGLGYGAELFTDPYWLYGPWLGALSGAATGAFLYDLLVFTGGESPVNYPIERAQRALRKTALSGRRDRGRRSSVPEEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G3X3</accession>
    <name>A0A2I2G3X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase with different specificitie</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_437406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702882.1">
        <property type="nucleotide sequence ID" value="XM_024849358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G3X3"/>
    <dbReference type="STRING" id="1392250.A0A2I2G3X3"/>
    <dbReference type="GeneID" id="36557057"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437406"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB47580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="328" mass="35916" checksum="D48EB60A05E02391" modified="2018-02-28" version="1">MESKYAKVHQSPKGPGDARPTALQIVKDAGREDNMTGKVILITGCSSGLGIETARALFQTGATLYLTARDLEKAKSALGDLVDSPRVHLLHLDLKSLESVRACAQEFLSRSKTLNILIANAGVMACPEGRTADGFETQFGTNHLAHFLLFYRLKSCLLSSSTPAFNSRVIIVASSAHRVSSVHLDNLSLQGEYEAWKSYGQSKTANIWTANEIERRYGAQGLHAFSLHPGAIATELLRHVSDEQKADWEKNDFLKNYWKSPEQGAATSVWAAVAKELEGTGGKYLDDCQIAPPADPSQRHGPGYAEWAYSPEMEARLWAKTLELLNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G416</accession>
    <name>A0A2I2G416_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P170DRAFT_456441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702911.1">
        <property type="nucleotide sequence ID" value="XM_024851620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G416"/>
    <dbReference type="STRING" id="1392250.A0A2I2G416"/>
    <dbReference type="GeneID" id="36559319"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_456441"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PLB47609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="569" mass="64304" checksum="9BAFE2942CEB2442" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G460</accession>
    <name>A0A2I2G460_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NadR/Ttd14 AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_476353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024702972.1">
        <property type="nucleotide sequence ID" value="XM_024853342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G460"/>
    <dbReference type="GeneID" id="36561040"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_476353"/>
    <dbReference type="OrthoDB" id="6118920at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB47670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="213" mass="24456" checksum="8271CB005487580C" modified="2018-02-28" version="1">MAYETEKPLKPKNVYIVGAHCTGKTTLIDALKEHFTPALCTEIFGTKTMHPYFLDEVVRLIMELEKRTADQVRDPIEGFKLQAHTLGTQFQFETVFNELWLLSDRSGIDPIVYAHFFLGSEASDRLVAMEEWDILRTKMKDGLVILCEPTNACWLSTDPVRVALHDLEEWRALGNAFKDWLDAQGIRYVPIPADLEKLEWRVQFVEGLIRSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4E1</accession>
    <name>A0A2I2G4E1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicular-fusion protein Sec17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_437481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703044.1">
        <property type="nucleotide sequence ID" value="XM_024849375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4E1"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4E1"/>
    <dbReference type="GeneID" id="36557074"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437481"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB47742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="292" mass="32716" checksum="194EA4FD29C8FB95" modified="2018-02-28" version="1">MAQDPRVLLQRADKALAGASGGFSFFGGRAEKYENAADLYTQAANAFRVQKQNKEAGLAFEKAASIQSQNLNEPDDAANSLTEAFKVYRKSDPEDATRVLSSAIQHYVLKGNLRRAATQQQYLAEVYEVELGDTKKAQEAYEKTAEWFESDNAEALANKHFLKAADLAALEGDYYKAIEHYERIGRSSISNNLMKWSVKDYFLKAGICHLASNDLVATNRALENYRDIDNTFASTREHQLLLDLAQAVEAGDQEGFADKLFQFDQLSKLDKWKTTLLLRIKNSIEEAGEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4M8</accession>
    <name>A0A2I2G4M8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_361053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703133.1">
        <property type="nucleotide sequence ID" value="XM_024844449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4M8"/>
    <dbReference type="GeneID" id="36552149"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_361053"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB47831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="59" mass="7287" checksum="1DA8E2F52CFE3CEB" modified="2018-02-28" version="1" fragment="single">YINKIIKRRLAQYINYVITEYRDKIYNIYTQKKAEFQKQVNNSNIKVRITANKYIKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4R5</accession>
    <name>A0A2I2G4R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P170DRAFT_410216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703172.1">
        <property type="nucleotide sequence ID" value="XM_024846837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4R5"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4R5"/>
    <dbReference type="GeneID" id="36554536"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410216"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PLB47870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="523" mass="58608" checksum="EE94CEBA4D7EF9CD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G4X4</accession>
    <name>A0A2I2G4X4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_410325</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB47930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703232.1">
        <property type="nucleotide sequence ID" value="XM_024846842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G4X4"/>
    <dbReference type="STRING" id="1392250.A0A2I2G4X4"/>
    <dbReference type="GeneID" id="36554541"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_410325"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB47930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="346" mass="37499" checksum="ED5A1EA4EC2058FC" modified="2018-02-28" version="1">MDLVAKYTSCLSKWQLNVAPGWQTVGASVLLAAGSLFIVSRALLFVRVLLSLFVLPGKPLRSFGPKGSWAVITGASDGLGKEFALQLARDGFNILLVSRTASKLTTLGDEITSQYPSVQTKTLAMDYARNQDSDFEKLKALVDELDVAVLVNNVGKSHDIPTPFALTPEDELTDIVTINCLGTLRTTQLVVPGMVQRKRGLVLTMGSFGGLLPTPLLATYSGSKAFLQQWSSALGSELEQHGITVELVQAYLITSAMSKIRRSSATIPNPRTFVKAVLSKIGRNGGSPTYAYSSSPYWSHGLMAWFLTCVTGTMGKLVLGQNRGMHESIRKRALRKAEREKGKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G619</accession>
    <name>A0A2I2G619_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_359166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703626.1">
        <property type="nucleotide sequence ID" value="XM_024844337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G619"/>
    <dbReference type="STRING" id="1392250.A0A2I2G619"/>
    <dbReference type="GeneID" id="36552037"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_359166"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="52"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="8">
        <location>
            <begin position="481"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="553" mass="61652" checksum="2A674BBB330BD473" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G689</accession>
    <name>A0A2I2G689_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_465773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703697.1">
        <property type="nucleotide sequence ID" value="XM_024852349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G689"/>
    <dbReference type="STRING" id="1392250.A0A2I2G689"/>
    <dbReference type="GeneID" id="36560047"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_465773"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB48395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="398" mass="45542" checksum="D29F3FF1AEC648FF" modified="2018-02-28" version="1">MSYRYGFYRRLIQGLLICVAAWTGLEGLFVHHRISAVEQIQRQGTRRGERIYIASMHWNNEAILRSHWNDALIQVVKTWGAENVFVSVFESGSWDNTKGVLQQLDNELDRLGVRRNVTLSDTTHQDEISAPSNEGWIDTPRNKKELRRIPYLARLRNLTVKPLEDLIRQGITFDKVLFLNDVVFTVEDVLSLLNTNDGQYAAACSLDFSKPPQYYDTFALRDSEGSETVMQKWPYFRAAASRNALLAMSPVPVRSCWNGMVAMPIEPFVSDKPLRFRGIPDSLALQHLEGSECCLIHADNPLSSTRGVYLNPNVRVGYNAQAYDSVHPASAWIGLQSVAIALWENRFRRWATTSLLKRFVVRKRVNRWKADLDDREEPGEFCLINEMQVLISNGWAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6C0</accession>
    <name>A0A2I2G6C0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphatidylserine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_497775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703726.1">
        <property type="nucleotide sequence ID" value="XM_024854119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6C0"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6C0"/>
    <dbReference type="GeneID" id="36561824"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_497775"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF13">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB48424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="411" mass="46539" checksum="71216FBC484C576F" modified="2018-02-28" version="1">MTTSQYEPRTAIVRDLRKLIFAVPGRVSAFRNAIKSARLKDGGGQDDMNRELIYDLDGYLRFCDDLLEWAPDVSSPGDELLRKLLVFYWVMDQPTTRGLQTPILPSTAGAELTPLSSWLVNYAREIGHWMDTKESADHTDSFYNNPLYNQEAYLWEDPPEGGWKSFNQFFARRWKDINVARPLDGDGDDTIIVHGADSKFGGSWDITGGFVTLDPSPIVAKGIEWPIDELLQWIGKDFNDGSLMHAFLSPHDYHRQHAPVSGKVVEVKNIQDQVFLQVTKGKDGKKLAPDRGLVRHPEEASRRHAKKNKQLEQLDAPDDAGYQWCQTRGLIIIETDNHGKVAVLPIGMAQVSSVVMKVEKNQCVKKGDEISYFQWGGSDIVIVFQEKVKYRSDLEVNETKINVRSQLATFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G6J2</accession>
    <name>A0A2I2G6J2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_427567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000005">
        <property type="protein sequence ID" value="PLB48483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024703785.1">
        <property type="nucleotide sequence ID" value="XM_024847780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G6J2"/>
    <dbReference type="STRING" id="1392250.A0A2I2G6J2"/>
    <dbReference type="GeneID" id="36555479"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_427567"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB48483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="225" mass="24527" checksum="680637B914E6B3AA" modified="2018-02-28" version="1">MDHSTSAVCRSGGSGNEDSGRGEVYNAFVPMDDLHFLPRYLWMPVQPGGRSESVTLLEMLRAIDRGQSRVSRFSPSPRFRSSGVYWGANLDPFVMMDNEITQAIRSDIQDTLRYAADNDAERQRRGQGHNSYSDGYSDGYAAGYTAGRADGHANGPTNGSTNGSTNGSTNGSTNSQGRGNDGGNNNGSNNGFFWFVDEWLGLGRGSHNTYRISYSAGFRTTYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7M1</accession>
    <name>A0A2I2G7M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P170DRAFT_475199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704170.1">
        <property type="nucleotide sequence ID" value="XM_024853232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7M1"/>
    <dbReference type="GeneID" id="36560930"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475199"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PLB48868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="822" mass="92532" checksum="4A6619009EF5CFD1" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G7Y9</accession>
    <name>A0A2I2G7Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P170DRAFT_455766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 23096</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB48963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704265.1">
        <property type="nucleotide sequence ID" value="XM_024851565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G7Y9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G7Y9"/>
    <dbReference type="GeneID" id="36559264"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_455766"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="57"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PLB48963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="308" mass="33669" checksum="1718AB207966F5BA" modified="2018-02-28" version="1">MSQSPKEQLEKLQAMLQRTGGRGGFGMGRMPTGGGPGGGVVAALVAVGLAGYALSNSFFNVDGGHRAIKYSRIGGVKKDIYSEGTHINIPWIETPVVYDVRAKPRNIASLTGTKDLQMVNITCRVLSKPRVDALPQIYRTLGKDFDERVLPSIVNEVLKSVVAQFNASQLITQRENVARLVRDNLARRAARFNIALDDVSLTHLTFSPEFTAAVEAKQVAQQEAQRAAFLVDKARQEKQAFIVRAQGEARSAELIGDAIKKSKSYIELRKIENARHIAQILQESGGKNKLYLDSQGLGLNVNVNAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G816</accession>
    <name>A0A2I2G816_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">SNF2 family helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P170DRAFT_407934</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704313.1">
        <property type="nucleotide sequence ID" value="XM_024846707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G816"/>
    <dbReference type="STRING" id="1392250.A0A2I2G816"/>
    <dbReference type="GeneID" id="36554406"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_407934"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="225"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="627"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="757"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PLB49011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="939" mass="106619" checksum="C74548EAE45D7A07" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G895</accession>
    <name>A0A2I2G895_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_358338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704412.1">
        <property type="nucleotide sequence ID" value="XM_024844282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G895"/>
    <dbReference type="STRING" id="1392250.A0A2I2G895"/>
    <dbReference type="GeneID" id="36551982"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_358338"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB49110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="502" mass="55752" checksum="66F1AAB002B9A69A" modified="2018-02-28" version="1">MTTSSRTESPPILPTFDSKPIPQVHYDLEAGPEPEFLSPGRRLTPRPTFLDGCFSPKDGHSTLKRQGSSDLVRYFHGPRDLDKHTKWPVFFRLHGSVLPKLIIPLSFIAIWSTVVTLVCKYVYDLGIDNILLTVTGLVVGLSLSFQSSTAYERWADGRKYWSLLHQASRNLARTIWICTTEREGEEGKEDVLDKLSAMNLILAFAVALKHKLRFEPDIGYDDLAGLVGHLDTFAKEAYDRQRLVPPRKSFWKSAGEYLSLSIAESDPRKHVKRSKKPLGHLPLEILNHLSVYVNQWIASDALSFNVYQTQAINSLASLNEVVTGTERVLDTPLPTAYTISIAQITWIYVLVLPFQLYDTLSWVTIPGSIAAAYIILGLSAIGREIENPFGDDVNDLPLDTYCRRIAQELDIITAMPAPNVDDFGSRDENLVFFPHSTAGYPEWKDRSLSDIRAILKTRVMANAHSPSPLNTPNASGFFGAAGAVSPSPCPSLGSRQCLSPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8C4</accession>
    <name>A0A2I2G8C4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_174875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704395.1">
        <property type="nucleotide sequence ID" value="XM_024842630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8C4"/>
    <dbReference type="GeneID" id="36550328"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_174875"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="182" mass="21107" checksum="5906A0A70885140F" modified="2018-02-28" version="1">MYIIGHWKGLHQKKGCPKISYLKHLCEYIQDTHCRRYKLDPLNGTIDPIDLCRPGCSMNRREEVQFIDSLSWGRQFPKPPMCFCISGSASACIGLKVDRVIGVKMNYQRPTRIYQERTRSPTPVQYQWSEILPYPVFLRRTLDAEDAWKVCLRQAVLGQRLRPTAYEVELSMPTKLIANGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G8F7</accession>
    <name>A0A2I2G8F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_436780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704456.1">
        <property type="nucleotide sequence ID" value="XM_024849220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G8F7"/>
    <dbReference type="GeneID" id="36556919"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_436780"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="63" mass="6758" checksum="C829B5AAB4D2C4B8" modified="2018-02-28" version="1">MVRRVIHAQDGLRNSGGLGTRPDQTGPARPTSAPLFCPPRPKSVIYLLDPESDCSGQTGRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G982</accession>
    <name>A0A2I2G982_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_184404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704747.1">
        <property type="nucleotide sequence ID" value="XM_024842684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G982"/>
    <dbReference type="GeneID" id="36550382"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_184404"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="161" mass="18774" checksum="F60C12D310F603BA" modified="2018-02-28" version="1">MGWVGATSDSKEQGNAGTRRWISIHEAVADPSCPFMHSNGKLKMVWRQRRFRVILGGLGNVTTFLPPQQDYIMPRARRREGQRRKKKKKKKKNISKLQPLHFKLHRETGNGNHWMDLLKKPKSKEPVGMTEAGTPFHFLLGGDFFRFLFWFLWVLELLVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9A0</accession>
    <name>A0A2I2G9A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P170DRAFT_357196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704751.1">
        <property type="nucleotide sequence ID" value="XM_024844205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9A0"/>
    <dbReference type="GeneID" id="36551905"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_357196"/>
    <dbReference type="OrthoDB" id="4497018at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PLB49449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="436" mass="48458" checksum="EA057C208010A3BF" modified="2018-02-28" version="1">MAMVTIDRPSVAPPVRVPAPPASDPPSSRRPSTSPGNSEVIADPNIANPRLLTNRACIYERRLPGDAYITAHVQRLQHGFYASSAVSDHDSDHVDFLGINFVFHSPNTMTHRFKAATIRASIHSSRDKSLSSAPATRKPSRRSSCSHDHRTPPRPRNPRFLKHAPHLLYGAMSPETLQWNYSLAGSIGVAQLPLMASLSPSGGMNGRYRRYEMMRIQGSVRSLKSPRGHKFDVEAGEIVWTLEENSLQRSGLPREFTFAMLIQKPHADSRVRFSLDIDPVLQFGCCTYPGWWLDIPKYQPAPRRPLDFRIQVGQRFEPITSSKGFNFATLESSFDDYVHMPGRKFSSMISPDGGGVPQDDNEIRRDVTRDLSMVEPVRGPARPPYSIEAGQLPLAAAFPGKIPVNQALVPMVPGFDPGSFSIRVLLDDKDDDKESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9P9</accession>
    <name>A0A2I2G9P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_437186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704904.1">
        <property type="nucleotide sequence ID" value="XM_024849308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9P9"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9P9"/>
    <dbReference type="GeneID" id="36557007"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_437186"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056398">
        <property type="entry name" value="Tudor_Coilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24054">
        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23086">
        <property type="entry name" value="Tudor_Coilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7357" evidence="3">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Coilin tudor" evidence="2">
        <location>
            <begin position="763"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="1253" mass="136814" checksum="1A57AA733DF944A9" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2G9V8</accession>
    <name>A0A2I2G9V8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P170DRAFT_475961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 23096</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000004">
        <property type="protein sequence ID" value="PLB49667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024704969.1">
        <property type="nucleotide sequence ID" value="XM_024853304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2G9V8"/>
    <dbReference type="STRING" id="1392250.A0A2I2G9V8"/>
    <dbReference type="GeneID" id="36561002"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_475961"/>
    <dbReference type="OrthoDB" id="4423012at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PLB49667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="224" mass="24661" checksum="1CDEDA3B4FDB8D2E" modified="2018-02-28" version="1">MSILSKSVGAVHELKTYTSSFWFDLGDVRNGDRRPSSPFSDGHCKKRPFKDRRSKPYHTAALFYLGAPRSRASLSLVSSIHEGTGVKTSGDLRSIVRSQDVRALRGWQAFLKVDPHSPAGGGFQGVGRPWKRGQGDPEDWLAEIVEASPKWTVDAPIHAIRMNEVKVGLINQVSEDTVQVDPLSKPLIQSIMIPADKDSLTTGGGKFRQNMSGMLTTITAKYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAP5</accession>
    <name>A0A2I2GAP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P170DRAFT_424384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705253.1">
        <property type="nucleotide sequence ID" value="XM_024847564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAP5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAP5"/>
    <dbReference type="GeneID" id="36555263"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_424384"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PLB49951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="465" mass="49774" checksum="32FD9E1FE3A95FBD" modified="2018-02-28" version="1">MKVTPLLIHGEDTLLSPPDRLDSCSASTTPFQGVTPDLALQAVKSSEQAFPSWSKTPPAQRRHLLNKVASLVEERSDELTQCMQEEMHAPTLWAKLNVQAGIDLLRETAGLISDSMAGHVPVSQGDSYAMVLKEPLGVVLAMVPWNAPVILGLRGVVAPLAAGNTVVLKGSELSPRTHYLLACLFRDAGVPPGVVNFILHRPEDAAVTFETMIGHPAIRKCNFTGSTNVGRIIASKAAWALKPVLLELGGKNFALVLNDADSEFAAGEIVKGAFLNNGQICMSTDLVFAVGDIADTLVPGILSHLETIKDTHTVISPASKQRLQLLVDDARAKGASIHQAKVPALQDAQFPATVIEGLTPDMEFFSNESFGPVVGIVRVQTETEAMDLIQRSTYGLSAAIFTRAHFKALKLAESVRAGAIHVNGMTVHDEATLPHGGQGESGWGRFGAKWGIEEFLQTKTIILNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAR8</accession>
    <name>A0A2I2GAR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P170DRAFT_354206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 23096</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB49966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705268.1">
        <property type="nucleotide sequence ID" value="XM_024844016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAR8"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAR8"/>
    <dbReference type="GeneID" id="36551716"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_354206"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="64"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PLB49966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="272" mass="29676" checksum="15C10DF7521BB8FF" modified="2018-02-28" version="1">MATFKQLVRFAVGDQTHYGELINTDGNMYTVQQFDGTPFDKLLSTDKVYTVNDLLSPIPSTPVVICIGLNYKEHAKEASLNVSTYPSVFTKPADALAGPFETIPIHRDAQSHLDYEGELTVVIGKDAKNVSTENALDYVLGYTAGNDLSARNFQLPEASGGQFCYAKSFDQFAPIGHVLISAQEVQAPQQLSLVTKVNGHVKQTTDTSDMIWGVREIVSHLSRGTTLRKGTVIMTGTPSGVGFFRKEFLQDGDVVEVEVGGMATVKNTMKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GAZ5</accession>
    <name>A0A2I2GAZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arsenate resistance ArsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P170DRAFT_353209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 23096</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFO01000003">
        <property type="protein sequence ID" value="PLB50052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024705354.1">
        <property type="nucleotide sequence ID" value="XM_024843966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I2GAZ5"/>
    <dbReference type="STRING" id="1392250.A0A2I2GAZ5"/>
    <dbReference type="GeneID" id="36551666"/>
    <dbReference type="VEuPathDB" id="FungiDB:P170DRAFT_353209"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000234275">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000027">
        <property type="entry name" value="Arsenical resistance protein ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014063">
        <property type="entry name" value="Arsenate-R_ArsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02690">
        <property type="entry name" value="resist_ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="8">
        <location>
            <begin position="76"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PLB50052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000234275"/>
        </source>
    </evidence>
    <sequence length="284" mass="32930" checksum="04134877EDEBE805" modified="2018-02-28" version="1">MHSTIPQQVVPDTRLTETSYRSLELPLSEDDPEIRQKYRPFILTDTTTEDWVNNLELSTALNMAEQNLRNTNERLKVLVLYGSLRRRSYSRLVAFEASRILFRLGCDVRVFDPEGLPVKSDSDANHPKVHELRELSRWSDGHVWVSPEQHGNLTAVFKNQIDWIPLTTGSVRPTQGRTLAIAQVCGGSQSFNAVNSLRILGRWMRMFTIPNQSSIPRAYTQFPDEGQPEDQRLMHSGNRDRLVDCMEEFVKYTILMRPHIELFGDRFSEREDRRLKEEMRNAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I2GBB6</accession>
    <name>A0A2I2GBB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P170DRAFT_491814</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus steynii IBT 23096</name>
        <dbReference type="NCBI Taxonomy" id="1392250"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name=